Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient
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- D Hayashi Reiko
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
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- Yamaoka Masaya
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
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- Nishizawa Hitoshi
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
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- Fukuda Shiro
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
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- Fujishima Yuya
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
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- Kimura Takekazu
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
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- Kozawa Jyunji
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
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- Kita Shunbun
- Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, Japan
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- Matsuoka Taka-aki
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
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- Otsuki Michio
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
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- Imagawa Akihisa
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
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- Ichida Kimiyoshi
- Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Japan
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- Taniguchi Atsuo
- Institute of Rheumatology, Tokyo Women's Medical University, Japan.
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- Maeda Norikazu
- Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, Japan
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- Funahashi Tohru
- Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, Japan
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- Shimomura Iichiro
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
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Abstract
<p>A 27 year-old severely obese man (BMI, 35.1) had hyperuricemia and multiple gouty tophi with bone erosion and destruction, resulting in gait disturbance for 6 years after the early onset of gout at 21 years of age. His hyperuricemia was associated with hyperinsulinemia in obesity and a genetic variant of the ABCG2 gene. In addition, multiple gouty tophi with bone erosion and destruction might have been caused by hypoadiponectinemia and the elevation of the patient' s pro-inflammatory cytokine (IL-1β) level with the accumulation of visceral fat. In this case, bone and Ga-67 scintigraphy were useful for detecting the location and magnitude of gouty tophi. </p>
Journal
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- Internal Medicine
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Internal Medicine 56 (9), 1071-1077, 2017
The Japanese Society of Internal Medicine
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Keywords
Details
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- CRID
- 1390282679852074496
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- NII Article ID
- 130005632011
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- ISSN
- 13497235
- 09182918
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- PubMed
- 28458315
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed