Treatment outcome of superselective intra-arterial chemotherapy combined with irradiation for head and neck squamous cell carcinoma
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- Moridera Kuniyasu
- Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine
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- Noguchi Kazuma
- Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine
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- Fujiwara Masayuki
- Department of Radiology, Hyogo College of Medicine
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- Yamamoto Satoshi
- Department of Radiology, Hyogo College of Medicine
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- Takaoka Kazuki
- Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine
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- Okui Shin
- Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine
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- Urade Masahiro
- Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine
Bibliographic Information
- Other Title
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- 頭頸部扁平上皮癌における超選択的動注化学療法併用放射線療法の治療成績
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Abstract
We investigated the treatment outcome of 31 patients (stage II: 5, III: 7, IV: 19) who had enforced superselective intra-arterial infusion with cisplatin (50 mg/week) for 3-4 weeks and concurrent radiotherapy (total dose: 40-60 Gy) (RADPLAT) for head and neck squamous cell carcinoma from December 2003 to January 2009. The mean age of the patients was 65.9 years, ranging from 40 to 82 years. Intra-arterial infusion was performed once a week by Seldinger's method. In primary tumors, the response rate was 100%, and the complete response rate was 71.0%. In cervical lymph node metastasis of level I and II, the complete response rate was 92.6%. The survival rate in each location was 79.5%, 83.3%, 60.0% and 66.7% in the tongue, oral floor, upper and lower gingival carcinoma, respectively. Out of 18 cases histopathologically examined, 10 cases demonstrated a cytological effect of grade III or more in the classification of Ohoshi and Shimosato. Among them, 9 cases were tongue and oral floor carcinoma.<br>Although 3 patients showed grade 3 mucositis and 17 patients showed grade 3 or more leucopenia as toxicities, all patients were able to complete the scheduled treatments. Therefore, RADPLAT is a superior treatment method for head and neck squamous carcinoma, and is suggested to be useful for organ preservation as a treatment method for tongue and oral floor carcinoma and cervical lymph node metastasis of level I and II.
Journal
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- Journal of Japanese Society of Oral Oncology
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Journal of Japanese Society of Oral Oncology 23 (4), 129-138, 2011
Japanese Society of Oral Oncology
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Details
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- CRID
- 1390001204345515904
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- NII Article ID
- 10030796057
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- NII Book ID
- AN10170059
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- ISSN
- 18844995
- 09155988
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed