Novel epigenetic change by histone lysine carboxymethylation
Project/Area Number |
24590450
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Nara Medical University |
Principal Investigator |
Fujii Kiyomu 奈良県立医科大学, 医学部, 研究員 (60284189)
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Co-Investigator(Kenkyū-buntansha) |
KUNIYASU Hiroki 奈良県立医科大学, 医学部, 教授 (00253055)
CHIHARA Yoshitomo 奈良県立医科大学, 医学部, 講師 (40405395)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 糖尿病 / リジン・カルボキシメチル化 / ヒストン・アセチル化 / DNAメチル化 / 糖化 / 糖化最終産物 / ヒストン / 遺伝子発現 / リジンカルボキシメチル化 / H3ヒストンK27 / トリメチル化 / ヒストン・リジン修飾 / カルボキシメチル化 / エピジェネティクス / p16 / H4ヒストン / リジン残基 / アセチル化ヒストン |
Outline of Final Research Achievements |
The influence of histone lysine carboxymethylation (HL-CM), which is occurred in diabetic condition, was examined by detection of HL-CM to be compared with histone acetylation, the promoter DNA methylation and p16 gene expression. The hyperglycemic-oxidative conditions associated with diabetes mellitus induced HL-CM, which was considered to affect histone acetylation. Metformin showed the possibility of preventing gene silencing by HL-the CM.
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Report
(5 results)
Research Products
(39 results)
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[Journal Article] Expression of MAS1 in breast cancer.2015
Author(s)
Luo Y, Tanabe E, Kitayoshi M, Nishiguchi Y, Fujiwara R, Matsushima S, Sasaki T, Sasahira T, Chihara Y, Fujii K, Ohmori H, Kuniyasu H
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Journal Title
Cancer Sci
Volume: 106
Issue: 9
Pages: 1240-1248
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Pro-chemotherapeutic effects of antibody against extracellular domain of claudin-4 in bladder cancer2015
Author(s)
Masaomi Kuwada, Yoshitomo Chihara, Yi Luo, Xiangru Li, Yukiko Nishiguchi, Rina Fujiwara, Takamistu Sasaki, Kiyomu Fujii, Hitoshi Ohmori, Kiyohide Fujimoto, Masuo Kondoh, Hiroki Kuniyasu
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Journal Title
Cancer Letters
Volume: 369
Issue: 1
Pages: 212-221
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serum CD10 is associated with liver metastasis in colorectal cancer.2014
Author(s)
Sasaki T, Kuniyasu H, Luo Y, Fujiwara R, Kitayoshi M, Tanabe E, Kato D, Shinya S, Fujii K, Ohmori H, Yamashita Y
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Journal Title
Journal of Surgical Research
Volume: 192
Issue: 2
Pages: 390-394
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Book] Current Research in Cancer 92015
Author(s)
Kuniyasu H, Ohmori H, Fujii K, Iwata N, Katsuragawa H, Fujiwara R, Sasaki T
Total Pages
218
Publisher
Significance of trans fatty acids in colorectal cancer.
Related Report
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