AUTS2 Gene: Keys to Understanding the Pathogenesis of Neurodevelopmental Disorders
Abstract
:1. Introduction
2. Structure and Expression of the AUTS2 Gene
3. Genotype–Phenotype Correlations of AUTS2 Syndrome
4. Protein Structure of AUTS2
5. Cytoplasmic AUTS2 Functions in Cytoskeletal Organization
6. Transcriptional Regulation by Nuclear AUTS2
7. The Role of AUTS2 in Neurogenesis
8. AUTS2 Regulates Neuronal Migration and Neuritogenesis during Corticogenesis
9. AUTS2 Restricts the Number of Excitatory Synapses to Regulate the E/I Balance
10. AUTS2 Is Involved in Cerebellar Development
11. Behavioral Abnormalities in Auts2 Mutant Mice
12. Conclusions and Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Hori, K.; Shimaoka, K.; Hoshino, M. AUTS2 Gene: Keys to Understanding the Pathogenesis of Neurodevelopmental Disorders. Cells 2022, 11, 11. https://doi.org/10.3390/cells11010011
Hori K, Shimaoka K, Hoshino M. AUTS2 Gene: Keys to Understanding the Pathogenesis of Neurodevelopmental Disorders. Cells. 2022; 11(1):11. https://doi.org/10.3390/cells11010011
Chicago/Turabian StyleHori, Kei, Kazumi Shimaoka, and Mikio Hoshino. 2022. "AUTS2 Gene: Keys to Understanding the Pathogenesis of Neurodevelopmental Disorders" Cells 11, no. 1: 11. https://doi.org/10.3390/cells11010011