Functional analysis of the role of hippocampal CA2 region in social behaviour and memory.
Project/Area Number |
26350979
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Basic / Social brain science
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Research Institution | Niigata University |
Principal Investigator |
Abe Manabu 新潟大学, 脳研究所, 准教授 (10334674)
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Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 海馬 / 記憶 / 遺伝子改変マウス |
Outline of Final Research Achievements |
The aim of this study was to examine the role of CA2 neurons in memory and social behavior. The function of the hippocampal CA2 region remains largely unknown. To control neural activity by using CA2 neuron-selective gene-targeting system, we made several knock-in lines, in which Cre recombinase or tetracycline transactivator was inserted into the translational initiation site of the targeted genes (Rgs14, Amigo2, Abat and so on) in frame. Additionally, we made a new line expressing tdTomato reporter under control of Cre recombinase. The mutant lines developed in this study could be useful tools for analysis of higher brain functions.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] PKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts.2017
Author(s)
Danno S, Kubouchi K, Mehruba M, Abe M, Natsume R, Sakimura K, Eguchi S, Oka M, Hirashima M, Yasuda H, Mukai H.
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Journal Title
Genes Cells.
Volume: 22
Issue: 2
Pages: 220-236
DOI
Related Report
Peer Reviewed
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[Journal Article] The balance between Cathepsin C and Cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model.2017
Author(s)
Shimizu T, Wisessmith W, Li J, Abe M, Sakimura K, Chetsawang B, Sahara Y, Tohyama K, Tanaka KF, Ikenaka K
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Journal Title
Glia
Volume: in press
Issue: 6
Pages: 917-930
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Trans-synaptic modulation of kainate receptor functions by C1q-like proteins.2016
Author(s)
Matsuda K, Budisantoso T, Mitakidis N, Sugaya Y, Miura E, Kakegawa W, Yamasaki M, Konno K, Uchigashima M, Abe M, Watanabe I, Kano M, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M.
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Journal Title
Neuron
Volume: in press
Issue: 4
Pages: 752-767
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Doublet 7 shortening, doublet 5-preferential poly-Glu reduction, and beating stall of sperm flagella in Ttll9-/- mice.2016
Author(s)
Konno A, Ikegami K, Konishi Y, Yang HJ, Abe M, Yamazaki M, Sakimura K, Yao I, Shiba K, Inaba K, Setou M.
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Journal Title
J Cell Sci.
Volume: 129
Issue: 14
Pages: 2757-2766
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] SAD-B Phosphorylation of CAST Controls Active Zone Vesicle Recycling for Synaptic Depression.2016
Author(s)
Mochida, S.*, Hida, Y., Tanifuji, S., Hagiwara, A., Hamada, S., Abe, M., Huan, M., Yasumura, M., Kitajima, I., Sakimura, K., Ohtsuka, T*.
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Journal Title
Cell Reports
Volume: 16
Issue: 11
Pages: 2901-2913
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury.2016
Author(s)
Katano T, Fukuda M, Furue H, Yamazaki M, Abe M, Watanabe M, Nishida K, Yao I, Yamada A, Hata Y, Okumura N, Nakazawa T, Yamamoto T, Sakimura K, Takao T, Ito S.
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Journal Title
eNeuro.
Volume: 3
Issue: 5
Pages: 0110-16
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance.2015
Author(s)
Ageta-Ishihara N, Yamazaki M, Konno K, Nakayama H, Abe M, Hashimoto K, Nishioka T, Kaibuchi K, Hattori S, Miyakawa T, Tanaka K, Huda F, Hirai H, Hashimoto K, Watanabe M, Sakimura K, Kinoshita M.
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Journal Title
Nat Commun.
Volume: 6
Issue: 1
Pages: 10090-10090
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus.2015
Author(s)
Wagatsuma K, Tani-Ichi S, Liang B, Shitara S, Ishihara K, Abe M, Miyachi H, Kitano S, Hara T, Nanno M, Ishikawa H, Sakimura K, Nakao M, Kimura H, Ikuta K.
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Journal Title
J Immunol.
Volume: 195
Issue: 4
Pages: 1804-14
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Cdk5/p35 is required for motor coordination and cerebellar plasticity.2014
Author(s)
He X, Ishizeki M, Mita N, Wada S, Araki Y, Ogura H, Abe M, Yamazaki M, Sakimura K, Mikoshiba K, Inoue T, Ohshima T.
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Journal Title
J Neurochem.
Volume: 131(1)
Issue: 1
Pages: 53-64
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Visualization of Corticotropin-Releasing Factor Neurons by Fluorescent Proteins in the Mouse Brain and Characterization of Labeled Neurons in the Paraventricular Nucleus of the Hypothalamus.2014
Author(s)
Itoi K, Talukder AH, Fuse T, Kaneko T, Ozawa R, Sato T, Sugaya T, Uchida K, Yamazaki M, Abe M, Natsume R, Sakimura K.
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Journal Title
Endocrinology.
Volume: 155(10)
Issue: 10
Pages: 4054-60
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] IL1RAPL1 knockout mice show learning deficiency, memory decline, hyperactivity and reduced anxiety-like behaviours.2014
Author(s)
Misato Yasumura, Tomoyuki Yoshida, Maya Yamazaki, Manabu Abe, Rie Natsume, Kouta Kanno, Takeshi Uemura, Keizo Takao, Kenji Sakimura, Takefumi Kikusui, Tsuyoshi Miyakawa, Masayoshi Mishina
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Journal Title
Scientific Reports
Volume: 4: 6613
Issue: 1
Pages: 6613-6613
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Proteasome dysfunction induces muscle growth defects and protein aggregation2014
Author(s)
Kitajima Y, Tashiro Y, Suzuki N, Warita H, Kato M, Tateyama M, Ando R, Izumi R, Yamazaki M, Abe M, Sakimura K, Ito H, Urushitani M, Nagatomi R, Takahashi R, and Aoki M
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Journal Title
J Cell Sci
Volume: 127
Pages: 5204-5217
DOI
Related Report
Peer Reviewed / Open Access
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