The effects of Emdogain^【○!R】 gel on wound healing of rat dental pulp

  • ANAN Hisashi
    Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
  • MATSUMOTO Noriyoshi
    Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
  • IZUMI Toshio
    Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
  • MATSURA Hiroshi
    Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
  • MOROTOMI Takahiko
    Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
  • EIDA Taro
    Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
  • SHIGEYAMA Chieko
    Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
  • KUNIMOTO Toshio
    Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
  • FUKUDA Yasuko
    Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
  • NISHIMURA Akihiro
    Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
  • KUHARA Yuko
    Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College

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Other Title
  • 歯髄創傷治癒に及ぼすエムドゲイン^【○!R】ゲルの影響

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Abstract

The aim of this study was to investigate the effects of Emdogain^[○!R] gel (EMD) on injured pulp tissue. After Pulpotomy was performed in the mandibular first molars of rats, EMD or calcium hydroxide (Ca(OH)_2) was applied to the exposed pulp tissue. The treated teeth were extracted after 7, 14 and 28 days and prepared for histochemical examination. In the EMD-treated rats, few cells expressed IL-1β throughout the experimental period, but cells expressing BMP-4 rapidly increased in number. Newly formed reparative dentin was observed earlier and larger in amount than that seen in the Ca(OH)_2-treated rats. On the other hand, in the Ca(OH)_2-treated rats, numerous macrophages expressing IL-1β were first observed around the abscess, and then cells expressing BMP-4 gradually increased in number with the reparative dentin formation. These results suggest that there may be a difference in the time and extent of expression of cytokine and growth factors between EMD and Ca(OH)_2-treated rats. It is speculated that EMD scarcely irritates injured pulp tissue, and may have the benefit efficacy to create a favorable environment promoting wound healing of the injured pulp tissue.

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