The effects of Emdogain^【○!R】 gel on wound healing of rat dental pulp
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- ANAN Hisashi
- Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
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- MATSUMOTO Noriyoshi
- Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
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- IZUMI Toshio
- Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
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- MATSURA Hiroshi
- Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
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- MOROTOMI Takahiko
- Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
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- EIDA Taro
- Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
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- SHIGEYAMA Chieko
- Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
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- KUNIMOTO Toshio
- Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
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- FUKUDA Yasuko
- Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
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- NISHIMURA Akihiro
- Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
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- KUHARA Yuko
- Section of Operative Dentistry and Endodontology, Department of Odontology, Fukuoka Dental College
Bibliographic Information
- Other Title
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- 歯髄創傷治癒に及ぼすエムドゲイン^【○!R】ゲルの影響
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Abstract
The aim of this study was to investigate the effects of Emdogain^[○!R] gel (EMD) on injured pulp tissue. After Pulpotomy was performed in the mandibular first molars of rats, EMD or calcium hydroxide (Ca(OH)_2) was applied to the exposed pulp tissue. The treated teeth were extracted after 7, 14 and 28 days and prepared for histochemical examination. In the EMD-treated rats, few cells expressed IL-1β throughout the experimental period, but cells expressing BMP-4 rapidly increased in number. Newly formed reparative dentin was observed earlier and larger in amount than that seen in the Ca(OH)_2-treated rats. On the other hand, in the Ca(OH)_2-treated rats, numerous macrophages expressing IL-1β were first observed around the abscess, and then cells expressing BMP-4 gradually increased in number with the reparative dentin formation. These results suggest that there may be a difference in the time and extent of expression of cytokine and growth factors between EMD and Ca(OH)_2-treated rats. It is speculated that EMD scarcely irritates injured pulp tissue, and may have the benefit efficacy to create a favorable environment promoting wound healing of the injured pulp tissue.
Journal
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- The Journal of Fukuoka Dental College
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The Journal of Fukuoka Dental College 36 (3), 119-127, 2010-09-30
The Society of Fukuoka Dental College
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Keywords
Details
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- CRID
- 1573105977377240192
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- NII Article ID
- 110007817663
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- NII Book ID
- AN00216288
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- ISSN
- 03850064
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- Text Lang
- ja
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- Data Source
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- CiNii Articles
- KAKEN