Bioinformatic analysis and functional genomics of refractory endometrial cancer subtype
Project/Area Number |
25462589
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
|
Research Institution | Kyoto University |
Principal Investigator |
Baba Tsukasa 京都大学, 医学(系)研究科(研究院), 講師 (60508240)
|
Co-Investigator(Kenkyū-buntansha) |
Konishi Ikuo 京都大学大学院医学研究科, 器官外科学・婦人科学産科学, 教授 (90192062)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 子宮体癌 / 漿液癌 / ドライバー / マイクロアレイ / 漿液性癌 / 転移 / 子宮内膜 |
Outline of Final Research Achievements |
Through bioinformatic analysis and functional genomics of refractory endometrial cancer subtypes, STAT1 pathway in serous carcinoma as well as GPR54-metastin axis in low grade endometrioid adenocarcinoma were detected as key molecules of tumor progression and new potent therapeutic targets. Based on these findings, development of molecular targeting therapy are in preparation as several international cooperative researches.
|
Report
(3 results)
Research Products
(26 results)
-
-
-
-
[Journal Article] Significance of histologic pattern of carcinoma and sarcoma components on survival outcomes of uterine carcinosarcoma.2016
Author(s)
Matsuo K, Takazawa Y, Ross MS, Elishaev E, Podzielinski I, Yunokawa M, Sheridan TB, Bush SH, Klobocista MM, Blake EA, Takano T, Matsuzaki S, Baba T, et al.
-
Journal Title
Ann Oncol.
Volume: 27
Issue: 7
Pages: 1257-1266
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
[Journal Article] Menstrual cyclic change of metastin/GPR54 in endometrium.2014
Author(s)
BabaT, Kang HS, Hosoe Y, Kharma B, Aniko K, Matsumura N, Hamanishi J, Yamaguchi K, Yoshioka Y, Koshiyama M, N\Mandai M, Murphy SK, Konishi I
-
Journal Title
Med Mol Morphol
Volume: 08
Issue: 2
Pages: 1-9
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Utilization of genomic signatures to identify high efficacy candidate drugs for chemo-refractory endometrial cancers.2013
Author(s)
Kharma B, Baba T, Mandai M, Matsumura N, Murphy SK, Kang HS, Yamanoi K, Hamanishi J, Yamaguchi K, Yoshioka Y, Konishi I.
-
Journal Title
Int J Cancer.
Volume: 133
Issue: 9
Pages: 2234-44
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 術前に「低リスク」と考えられる子宮体癌に対して腹腔鏡手術を行う場合の問題点2015
Author(s)
平山 貴裕, 馬場 長, 堀江 昭史, 安彦 郁, 松村 謙臣, 近藤 英治, 山口 建, 濱西 潤三, 吉岡 弓子, 越山 雅文, 小西 郁生
Organizer
第67回日本産科婦人科学会学術講演会
Place of Presentation
パシフィコ横浜
Year and Date
2015-04-09
Related Report
-
-
-