The maintenance mechanism of hematopoietic microenvironment bytranscription factor GATA-2
Project/Area Number |
20790668
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Hematology
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Research Institution | Tohoku University |
Principal Investigator |
OKITSU Yoko Tohoku University, 病院, 医員 (80451558)
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Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | GATA-2 / 間葉系幹細胞 / 造血微小環境 / 脂肪細胞 |
Research Abstract |
GATA-2 is a transcription factor indispensable for hematopoiesis by regulating the proliferation and maturation of hematopoietic stem cells (HSC).We analyzed the function of GATA-2 in mesenchymal stem cells(MSC), and revealed that GATA-2 is activated in MSC and regulates the proliferation and maturation of MSC. Because hematopoietic microenvironment is formed by cells derived from MSC, it is suggested that GATA-2 is essential for not only HSC but also hematopoietic microenvironment by maintaining immaturity of MSC.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Plasma cell leukemia maintaining complete remission by syngeneic stem cell transplantation combined with low-dose thalidomide maintenance therapy2009
Author(s)
be M, Yokoyama H, Tohmiya Y, Okitsu Y, Ohguchi H, Kohata K, Yamamoto J, Onishi Y, Ishizawa K, Kameoka J, Harigae H
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Journal Title
Intern Med 48(20)
Pages: 1833-5
NAID
Related Report
Peer Reviewed
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[Journal Article] Acquired hemophilia A with sigmoid colon cancer: successful treatment with rituximab followed by sigmoidectomy2009
Author(s)
Ichikawa S, Kohata K, Okitsu Y, Suzuki M, Nakajima S, Yamada MF, Onishi Y, Yamamoto J, Suzuki S, Ishizawa K, Kameoka J, Harigae H
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Journal Title
Int J Hematol 90(1)
Pages: 33-6
NAID
Related Report
Peer Reviewed
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[Journal Article] yeloablative cord blood transplantation for adults with hematological malignancies using tacrolimus and short-term methotrexate for graft-versus-host disease prophylaxis: single-institution analysis2008
Author(s)
Yamada MF, Miyamura K, Fujiwara T, Kohata K, Okitsu Y, Ohguchi H, Yamamoto J, Yokoyama H, Tomiya Y, Ishizawa K, Kameoka J, Harigae H.
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Journal Title
Transplant Proc. Dec 40(10)
Pages: 3637-42
Related Report
Peer Reviewed
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[Presentation] S状結腸癌に合併した後天性血友病の1例2009
Author(s)
市川聡, 木幡桂, 沖津庸子, 大西康, 山本譲司, 山田実名美, 鈴木宗三, 石澤賢一, 亀岡淳一, 張替秀郎
Organizer
第187回日本内科学会東北地方会例会
Place of Presentation
仙台
Year and Date
2009-02-21
Related Report
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