SN-38 as a radio-sensitizer for colorectal cancer by suppressing radiation-induced HIF-1a overexpression
Project/Area Number |
26462005
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | The University of Tokyo |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
石原 聡一郎 東京大学, 医学部附属病院, 講師 (00376443)
山口 博紀 東京大学, 医学部附属病院, 登録研究員 (20376445)
津野 寛和 東京大学, 医学部附属病院, 客員研究員 (50282637)
須並 英二 東京大学, 医学部附属病院, 登録研究員 (70345205)
渡邉 聡明 東京大学, 医学部附属病院, 教授 (80210920)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 放射線療法 / SN-38 / HIF-1α / 化学放射線療法 / 直腸癌 / CPT-11 / 大腸癌 |
Outline of Final Research Achievements |
HIF-1a is the key molecule induced by hypoxia. It activates various pathways protecting cell and tissue from hypoxic stress. Radiotherapy is one of the standard therapy for colorectal cancer, and we found that radiation induced HIF-1a in colorectal cancer cells. We also found that SN-38, which is widely used as an anti-cancer drug for colorectal cancer, effectively suppressed HIF-1a induced by radiation. SN-38 was demonstrated to be a promising radio-sensitizer for colorectal cancer.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Intraoperative colonoscopy in patients with colorectal cancer: A review of recent developments.2016
Author(s)
Kawai K, Iida Y, Ishihara S, Yamaguchi H, Nozawa H, Hata K, Kiyomatsu T, Tanaka T, Nishikawa T, Yasuda K, Otani K, Murono K, Watanabe T.
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Journal Title
Digestive Endoscopy
Volume: 未定
Issue: 6
Pages: 633-640
DOI
Related Report
Peer Reviewed
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[Journal Article] Level of arterial ligation in sigmoid colon and rectal cancer surgery.2016
Author(s)
Yasuda K, Kawai K, Ishihara S, Murono K, Otani K, Nishikawa T, Tanaka T, Kiyomatsu T, Hata K, Nozawa H, Yamaguchi H, Aoki S, Mishima H, Maruyama T, Sako A, Watanabe T.
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Journal Title
World Journal of Surgical Oncology
Volume: 14
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic impact of lymph node dissection is different for male and female colon cancer patients: a propensity score analysis in a multicenter retrospective study2016
Author(s)
Ishihara S, Otani K, Yasuda K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Kazama S, Yamaguchi H, Sunami E, Kitayama J, Sugihara K, Watanabe T.
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Journal Title
International Journal of colorectal disease
Volume: 未定
Issue: 6
Pages: 1149-1155
DOI
Related Report
Peer Reviewed
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[Journal Article] CD133 Expression at the Metastatic Site Predicts Patients' Outcome in Colorectal Cancer with Synchronous Liver Metastasis.2016
Author(s)
Kishikawa J, Kazama S, Oba K, Hasegawa K, Anzai H, Harada Y, Abe H, Matsusaka K, Hongo K, Oba M, Yasuda K, Otani K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Yamaguchi H, Ishihara S, Sunami E, Ushiku T, Kitayama J, Fukayama M, Kokudo N, Watanabe T.
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Journal Title
Annals of Surgical Oncology
Volume: 未定
Related Report
Peer Reviewed
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[Journal Article] CD133 Expression in Lymph Node Metastases Is Associated with Tumor Aggressiveness During Lymph Node Metastasis in Colorectal Cancer.2015
Author(s)
Kazama S, Kishikawa J, Yasuda K, Otani K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Yamaguchi H, Ishihara S, Sunami E, Watanabe T. Anticancer Res. 2015 Dec;35(12):6599-605.
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Journal Title
Anticancer Research
Volume: 35
Pages: 6599-605
Related Report
Peer Reviewed
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[Journal Article] Nomograms for colorectal cancer: A systematic review.2015
Author(s)
Kawai K, Sunami E, Yamaguchi H, Ishihara S, Kazama S, Nozawa H, Hata K, Kiyomatsu T, Tanaka J, Tanaka T, Nishikawa T, Kitayama J, Watanabe T.
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Journal Title
World Journal of Gastroenterology
Volume: 21
Issue: 41
Pages: 11877-86
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Outcome of salvage surgery for colorectal cancer initially treated by upfront endoscopic therapy.2015
Author(s)
Nozawa H, Ishihara S, Fujishiro M, Kodashima S, Ohtani K, Yasuda K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Kazama S, Sunami E, Kitayama J, Watanabe T.
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Journal Title
Surgery
Volume: 159
Issue: 3
Pages: 713-20
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Prognostic Impact of Histologic Type in Curatively Resected Stage IV Colorectal Cancer: A Japanese Multicenter Retrospective Study.2015
Author(s)
Shibata J, Kawai K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Hata K, Nozawa H, Kazama S, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Sugihara K, Watanabe T.
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Journal Title
Annals of Surgical Oncology
Volume: Suppl 3
Issue: S3
Pages: 621-629
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] A multicenter phase II study of preoperative chemoradiotherapy with S-1 plus oxaliplatin for locally advanced rectal cancer (SHOGUN trial).2015
Author(s)
Matsusaka S, Ishihara S, Kondo K, Horie H, Uehara K, Oguchi M, Murofushi K, Ueno M, Mizunuma N, Shimbo T, Kato D, Okuda J, Hashiguchi Y, Nakazawa M, Sunami E, Kawai K, Yamashita H, Okada T, Ishikawa Y, Nakajima T, Watanabe T.
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Journal Title
Radiotherapy and Oncology
Volume: 116
Issue: 2
Pages: 209-13
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Large Colorectal Carcinoma Is Predictive of Recurrence After Adjuvant Chemotherapy Using Oxaliplatin.2015
Author(s)
Nozawa H, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Kazama S, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Watanabe T.
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Journal Title
Anticancer Research
Volume: 35
Pages: 5073-8
Related Report
Peer Reviewed
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