Yok- omizo K, Isohama Y. Glycyrrhizin attenuates mucus production by inhibition of MUC5AC mRNA expression in vivo and in vitro
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- Nishimoto Yuki
- Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan
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- Hisatsune Akinori
- Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan
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- Katsuki Hiroshi
- Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan
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- Miyata Takeshi
- Laboratory of Presymptomatic Medical Pharmacology, Faculty of Pharmaceutical Sciences, Sojo University, Japan
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- Yokomizo Kazumi
- Laboratory of Presymptomatic Medical Pharmacology, Faculty of Pharmaceutical Sciences, Sojo University, Japan
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- Isohama Yoichiro
- Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan
書誌事項
- タイトル別名
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- Glycyrrhizin Attenuates Mucus Production by Inhibition of MUC5AC mRNA Expression In Vivo and In Vitro
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抄録
We have previously indicated that glycyrrhizin (GL), a major component of licorice, has glucocorticoid-like anti-inflammatory effects in cultured airway epithelial cells and suggested its usefulness in the treatment of inflammatory respiratory diseases. On the other hand, mucus hypersecretion in the respiratory tract and goblet cell hyperplasia in the airway epithelium contribute to the morbidity and mortality associated with airway inflammatory diseases. This study, therefore, aimed to examine the effects of GL on airway mucus hyperproduction and define the mechanisms behind these effects. In an in vivo model, GL significantly attenuated goblet cell hyperplasia and MUC5AC mRNA expression in mice treated with lipopolysaccharide or interleukin-4. In addition, GL significantly attenuated MUC5AC protein and mRNA expression by tumor growth factor (TGF)-α in cultured NCI-H292 cells. GL also attenuated TGF-α–stimulated MUC5AC promoter activity in a luciferase reporter gene assay, but did not affect the stability of MUC5AC mRNA. Taken together, we concluded that GL has an inhibitory effect on mucus hyperproduction both in vivo and in vitro and that GL-mediated inhibition may be mediated through the inhibition of MUC5AC gene transcription.<BR>[Supplementary Figures: available only at http://dx.doi.org/10.1254/jphs.09344FP]
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 113 (1), 76-83, 2010
公益社団法人 日本薬理学会
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詳細情報
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- CRID
- 1390282680155345152
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- NII論文ID
- 10027745175
- 130000251909
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 10676979
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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