Tidal volume and diaphragm muscle activity in rats with cervical spinal cord injury

  • Imagita Hidetaka
    Graduate School of Health Sciences, Kio University: 4-2-2 Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan
  • Nishikawa Akira
    Graduate School of Health Sciences, Kio University: 4-2-2 Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan Department of Sports Health Management, Faculty of Business Information, Jobu University, Japan
  • Sakata Susumu
    Graduate School of Health Sciences, Kio University: 4-2-2 Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan
  • Nishii Yasue
    Graduate School of Health Sciences, Kio University: 4-2-2 Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan
  • Minematsu Akira
    Graduate School of Health Sciences, Kio University: 4-2-2 Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan
  • Moriyama Hideki
    Department of Physical Therapy, Faculty of Health Sciences, Kobe University, Japan
  • Kanemura Naohiko
    Department of Physical Therapy, Faculty of Health Sciences, Saitama Prefectural University, Japan
  • Shindo Hanae
    Graduate School of Health Sciences, Kio University: 4-2-2 Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan Department of Physical Therapy, Keihan Life Support Company, Japan

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[Purpose] The purpose of this study was to make an experimental model of cervical spinal cord injury (CSCI) using Wistar rats, in order to analyze the influence of CSCI on the respiratory function. [Subjects] Thirty-two male 12-week-old Wistar rats were used. [Methods] The CSCI was made at the levels from C3 to C7, and we performed pneumotachography and electromyography (EMG) on the diaphragm. Computed tomography was used to determine the level of spinal cord damage. [Results] After the operation, the tidal volume of the rats with a C3 level injury decreased to approximately 22.3% of its pre-injury value. In addition, in the same rats, the diaphragmatic electromyogram activity decreased remarkably. Compared with before CSCI, the tidal volume decreased to 78.6% of its pre-injury value in CSCI at the C5 level, and it decreased to 94.1% of its pre-injury value in CSCI at the C7 level. [Conclusion] In the rats that sustained a CSCI in this study, the group of respiratory muscles that receive innervation from the thoracic spinal cord was paralyzed. Therefore, the EMG signal of the diaphragm increased. These results demonstrate that there is a relationship between respiratory function and the level of CSCI.

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