Issue 17, 2011

Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

Abstract

Amyloid nitroxyl radical (nitroxide) ligands were used to detect amyloid-β fibrils, the main constituents of senile plaques in Alzheimer's disease, using anisotropic ESR spectra, and were found to affect the aggregation process due to the radical functionality. These compounds have great potential as novel and multifunctional probes, combining spin labels, spin probes, and fluorescence probes.

Graphical abstract: Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

Supplementary files

Article information

Article type
Communication
Submitted
24 Dec 2010
Accepted
11 Mar 2011
First published
25 Mar 2011

Chem. Commun., 2011,47, 5070-5072

Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

F. Mito, T. Yamasaki, Y. Ito, M. Yamato, H. Mino, H. Sadasue, C. Shirahama, K. Sakai, H. Utsumi and K. Yamada, Chem. Commun., 2011, 47, 5070 DOI: 10.1039/C0CC05764A

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