Original articleGeneral thoracicClinicopathologic Features of Submucosal Esophageal Squamous Cell Carcinoma
Section snippets
Patient Population
The Institutional Review Board of Hiroshima University Hospital, Hiroshima, Japan, approved this retrospective study. The retrospective study included 137 consecutive patients with early esophageal squamous cell carcinoma that invaded only as far as the submucosa (T1b) who underwent esophagectomy at our institution between January 1990 and December 2011. Our inclusion criteria for participation in the study were as follows: (1) SESCC with submucosal invasion was diagnosed after postoperative
Results
There were 119 men and 18 women with a mean age of 64 years (range, 47 to 81); their clinicopathologic characteristics are shown in Table 1. All patients had squamous cell carcinoma. A complete macroscopic and microscopic resection of the primary tumor (R0 resection) was achieved in all patients, of whom 41 underwent three-field lymphadenectomy and 90 underwent two-field lymphadenectomy. There were 4 patients with pM1 stage because of M1 lymph node metastasis. The median number of resected
Comment
The main finding of this study is that a depth of invasion deeper than SM1 signified higher rates of recurrence and distant metastasis. However, the prognoses of SM2 patients (5-year survival 83.3%) were similar to those of SM1 patients (5-year survival 83.3%), whereas the prognoses of SM3 patients (5-year survival 58.1%) were significantly worse than for patients with more superficial submucosal invasion, and were closer to those of patients with locally advanced disease.
Only 3 patients with
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