Issue 58, 2012

Prediction of the stability of modified RNA duplexes based on deformability analysis: oligoribonucleotide derivatives modified with 2′-O-cyanoethyl-5-propynyl-2-thiouridine as a promising component

Abstract

We describe a method to predict the stability of a modified RNA duplex. Ten unique modified RNA duplexes showed a linear relationship between the calculated and experimentally determined duplex stabilities.

Graphical abstract: Prediction of the stability of modified RNA duplexes based on deformability analysis: oligoribonucleotide derivatives modified with 2′-O-cyanoethyl-5-propynyl-2-thiouridine as a promising component

Supplementary files

Article information

Article type
Communication
Submitted
11 May 2012
Accepted
31 May 2012
First published
07 Jun 2012

Chem. Commun., 2012,48, 7313-7315

Prediction of the stability of modified RNA duplexes based on deformability analysis: oligoribonucleotide derivatives modified with 2′-O-cyanoethyl-5-propynyl-2-thiouridine as a promising component

Y. Masaki, R. Miyasaka, K. Hirai, H. Tsunoda, A. Ohkubo, K. Seio and M. Sekine, Chem. Commun., 2012, 48, 7313 DOI: 10.1039/C2CC33409G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements