Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus
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- Masutani Hiroshi
- Institute for Virus Research, Graduate School of Biostudies, Kyoto University
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- Yoshihara Eiji
- Institute for Virus Research, Graduate School of Biostudies, Kyoto University Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University
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- Masaki So
- Institute for Virus Research, Graduate School of Biostudies, Kyoto University
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- Chen Zhe
- Institute for Virus Research, Graduate School of Biostudies, Kyoto University
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- Yodoi Junji
- Institute for Virus Research, Graduate School of Biostudies, Kyoto University
抄録
Thioredoxin binding protein −2/ thioredoxin interacting protein is an α-arrestin protein that has attracted much attention as a multifunctional regulator. Thioredoxin binding protein −2 expression is downregulated in tumor cells and the level of thioredoxin binding protein is correlated with clinical stage of cancer. Mice with mutations or knockout of the thioredoxin binding protein −2 gene are much more susceptible to carcinogenesis than wild-type mice, indicating a role for thioredoxin binding protein −2 in cancer suppression. Studies have also revealed roles for thioredoxin binding protein −2 in metabolic control. Enhancement of thioredoxin binding protein −2 expression causes impairment of insulin sensitivity and glucose-induced insulin secretion, and β-cell apoptosis. These changes are important characteristics of type 2 diabetes mellitus. Thioredoxin binding protein −2 regulates transcription of metabolic regulating genes. Thioredoxin binding protein −2-like inducible membrane protein/ arrestin domain containing 3 regulates endocytosis of receptors such as the β2-adrenergic receptor. The α-arrestin family possesses PPXY motifs and may function as an adaptor/scaffold for NEDD family ubiquitin ligases. Elucidation of the molecular mechanisms of α-arrestin proteins would provide a new pharmacological basis for developing approaches against cancer and type 2 diabetes mellitus.<br>
収録刊行物
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 50 (1), 23-34, 2011
一般社団法人 日本酸化ストレス学会
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詳細情報
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- CRID
- 1390282679649599872
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- NII論文ID
- 130004466667
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- ISSN
- 18805086
- 09120009
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可