Issue 50, 2019

Enhanced autophagy induction via the mitochondrial delivery of methylated β-cyclodextrin-threaded polyrotaxanes using a MITO-Porter

Abstract

Failure of autophagy induction results in the accumulation of abnormal mitochondria to cause neurodegenerative diseases. Artificial autophagy activation via the mitochondrial delivery of polyrotaxane with autophagy induced activity is achieved using a MITO-Porter, a nanodevice for mitochondrial delivery. This strategy can be applied to innovative research and therapy.

Graphical abstract: Enhanced autophagy induction via the mitochondrial delivery of methylated β-cyclodextrin-threaded polyrotaxanes using a MITO-Porter

Supplementary files

Article information

Article type
Communication
Submitted
27 Apr 2019
Accepted
28 May 2019
First published
03 Jun 2019

Chem. Commun., 2019,55, 7203-7206

Enhanced autophagy induction via the mitochondrial delivery of methylated β-cyclodextrin-threaded polyrotaxanes using a MITO-Porter

Y. Yamada, S. Daikuhara, A. Tamura, K. Nishida, N. Yui and H. Harashima, Chem. Commun., 2019, 55, 7203 DOI: 10.1039/C9CC03272J

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