YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
誌上シンポジウム
膵島ミトコンドリアを標的とした分子送達技術の開発及び糖尿病治療への展開
山田 勇磨
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ジャーナル フリー

2019 年 139 巻 1 号 p. 41-45

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The destruction of β cells of pancreatic islets results in a reduced level of insulin secretion, thus resulting in the onset of diabetes. Diabetes caused by such a decrease in insulin secretion has been reported to be associated with mitochondrial dysfunction. Because of this, mitochondrial therapy would be expected to be a useful and productive strategy for the treatment of this disease. We previously reported the development of a MITO-Porter, a liposome-based nanocarrier that permits macromolecular cargos to be delivered into mitochondria via membrane fusion. In this presentation, we present our current findings on the development of a mitochondrial nanocarrier system aimed at the development of a novel method for treating and preventing diabetes. The system includes “a nanocarrier system for nucleic acids targeted to pancreatic β cells”, and “an in vivo system for the delivery of nucleic acids targeting the pancreas”. In this presentation, we propose the use of a “mitochondrial nanocarrier system” as a novel method for the treatment and prevention of diabetes, and discuss the contribution of mitochondrial nanocarrier systems to innovative drug development.

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© 2019 The Pharmaceutical Society of Japan
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