Enhancement in selective mitochondrial association by direct modification of a mitochondrial targeting signal peptide on a liposomal based nanocarrier

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抄録

The focus of this study was on the development of a nano carrier targeted to mitochondria, a promising therapeutic drug target. We synthesized a lipid derivative that is conjugated with a mitochondrial targeting signal peptide (MTS), which permits the selective delivery of certain types of proteins to mitochondria. We then explored the use of an innovative technology in which MTS and the MITO-Porter were integrated. The latter is a liposome that delivers cargos to mitochondria via membrane fusion. The results indicate that the combination of MTS and the MITO-Porter would be useful for selective mitochondrial delivery via membrane fusion. (C) 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

収録刊行物

  • Mitochondrion

    Mitochondrion 13 (5), 526-532, 2013-09

    Elsevier sci ltd

詳細情報

  • CRID
    1050282813991208960
  • NII論文ID
    120005394544
  • HANDLE
    2115/54782
  • ISSN
    15677249
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • IRDB
    • CiNii Articles

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