Mitochondrial targeting functional peptides as potential devices for the mitochondrial delivery of a DF-MITO-Porter
抄録
To achieve mitochondrial therapy, we previously reported on the use of an octaarginine (R8) modified Dual Function (DF)-MITO-Porter for delivering molecules to mitochondria in living cells. In this study, using isolated mitochondria, homogenates and living cells, we evaluated the utility of mitochondrial targeting functional peptides as a ligand for delivering carriers. The S2 peptide modified carrier showed a high mitochondrial targeting activity in homogenates and living cells. In addition, the S2 peptide had a lower cell toxicity compared to R8 modified liposomes. The S2 peptide represents a potentially useful moiety for constructing an efficient and safe mitochondrial delivery system. (C) 2013 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
収録刊行物
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- Mitochondrion
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Mitochondrion 13 (6), 610-614, 2013-11
Elsevier sci ltd
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詳細情報
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- CRID
- 1050564288968040448
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- NII論文ID
- 120005460249
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- HANDLE
- 2115/56636
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- ISSN
- 15677249
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- CiNii Articles