Mitochondrial targeting functional peptides as potential devices for the mitochondrial delivery of a DF-MITO-Porter

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抄録

To achieve mitochondrial therapy, we previously reported on the use of an octaarginine (R8) modified Dual Function (DF)-MITO-Porter for delivering molecules to mitochondria in living cells. In this study, using isolated mitochondria, homogenates and living cells, we evaluated the utility of mitochondrial targeting functional peptides as a ligand for delivering carriers. The S2 peptide modified carrier showed a high mitochondrial targeting activity in homogenates and living cells. In addition, the S2 peptide had a lower cell toxicity compared to R8 modified liposomes. The S2 peptide represents a potentially useful moiety for constructing an efficient and safe mitochondrial delivery system. (C) 2013 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

収録刊行物

  • Mitochondrion

    Mitochondrion 13 (6), 610-614, 2013-11

    Elsevier sci ltd

詳細情報

  • CRID
    1050564288968040448
  • NII論文ID
    120005460249
  • HANDLE
    2115/56636
  • ISSN
    15677249
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • IRDB
    • CiNii Articles

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