PAPS PapersConcordance for neuroblastoma in monozygotic twins: case report and review of the literature
Section snippets
Clinical features and outcomes
The patients were infant male twins born by cesarean delivery following a healthy pregnancy at 36 weeks' gestation to unrelated parents. During the gestational course, the twins did not undergo exposure to extrinsic factors that might affect neuroblastomas. At 4 months of age, twin 2 presented with hepatomegaly and a right suprarenal mass (Fig. 1A-D). The patient's urinary vanillylmandelic acid (339 µg/mg Cr) and homovanillic acid (447 µg/mg Cr) were markedly elevated. Metaiodobenzylguanidine
Discussion
Neuroblastomas can be multifocal and can be concordant or discordant (only one of the twins has the tumor) among monozygotic twins. To the best of our knowledge, as shown in Table 1, only 9 sets of monozygotic twins concordant for neuroblastoma, including the current cases, have been described; and no concordant neuroblastoma cases have been described for dizygotic twins [4], [5], [6], [7], [8], [9], [10], [11].
Neuroblastomas can present in multiple ways. The most frequent presentation occurs
Acknowledgments
We thank Dr Tomoko Iehara, Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan, for the personal communication. The English used in this manuscript was reviewed by Brian Quinn (Editor-in-Chief, Japan Medical Communication).
References (13)
- et al.
Sympathicoblastoma: radiological findings in forty-three cases
Clin Radiol
(1963) - et al.
Common solid tumors of childhood
N Engl J Med
(1991) - et al.
Histopathologic prognostic factors in neuroblastic tumors: definition of subtypes of ganglioneuroblastoma and an age-linked classification of neuroblastomas
J Natl Cancer Inst
(1984) - et al.
Novel risk stratification of patients with neuroblastoma by genomic signature, which is independent of molecular signature
Oncogene
(2008) The surgical significance of tumors in identical twins: a short review of the literature and a report of sympathicoblastoma occurring in monozygotic twins
Am Surg
(1953)Neuroblastoma (sympathicoblastoma) in Northern Ireland: a review over a ten year period
Ulster Med J
(1963)
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