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IWASAKI Shigeo  岩崎 成夫

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… Alternative Names

岩崎 茂夫  イワサキ シゲオ

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Researcher Number 00013326
Affiliation (based on the past Project Information) *help 1997: The Kitasato Institute, Head director, 生物機能研究所, 部長
1993 – 1996: INST.MOL.CELL.BIOSCI., UNIV.KYOTO ; PROFESSOR, 分子細胞生物学研究所, 教授
1993: 東京大学, 分子細胞生物研究所, 教授
1987 – 1992: Institute of Applied Microbiology, The University of Tokyo, 応用微生物研究所, 教授
1988: 東京大学, 応微研, 教授
Review Section/Research Field
Principal Investigator
Chemical pharmacy
Except Principal Investigator
Chemical pharmacy / 医薬分子機能学 / Bioorganic chemistry
Keywords
Principal Investigator
チューブリン / 有糸分裂阻害剤 / キュラシンA / ウスチロキシン / 分子認識 / tubulin / 微小管機能 / リゾキシン / チュ-ブリン / アレナスタチンA … More / 複合体構造 / 分子設計 / 微小管機能制御物質 / 生合成 / 分子認識機構 / Maytansine部位 / Rhizoxin / Phomopsin A / 有糸分裂 / メイタンシン / strucuture-activity / Photoaffinity label / 100th amino acid / maytansine site / rhizoxin / β-チュブリン変異株 / A.nidulans / メイタンシン類 / 光アフィニティラベル / 構造活性相関 / 光アフィニティ-ラベル / 100番目アミノ酸 / メイタンシン結合部位 / antifungal / antitumor / peletelet aggregation inhibition / neurotropic / microbial products / Effect on eucaryotic cells / 向真経性 / 微小管タンパク活性阻害 / アクチン / 抗カビ性 / 抗腫瘍性 / 血小板凝集抑制 / 向神経性 / 微生物代謝産物 / 向真核細胞活性 / arenastatin A / curacin A / ustiloxins / molecular design / action mechanism / antimitotic agent / 作用機作 / curacin / aza-combretastatin / ustiloxin / molecular recognition / microtubules / フォモプシン / 分子確認 / キュラシン / アザコンプレタスタチン / 分子機能 / Synthetic Supply / Natural Sources / Bioactivity / Microbial Products / Medicinal Resources / 化学合成 / 作用機構 / 生物活性 / 活性誘導体 / 天然資源からの検索 / 生理活性 / 微生物代謝物 / 医薬資源 / 微小管 / 新規抗がん剤 / アザコンブレタスタチン / Ustiloxin / Dolastatin 10 / Calicheamicin / Esperamicin / Enediyne構造 / Endiyne構造 / 抗腫瘍抗生物質 / Dynemicin A / MAY部位 / VLB / 精密構造認識 … More
Except Principal Investigator
抗腫瘍活性 / 微小管重合阻害 / リゾキシン / 稲イモチ病菌 / 有糸分裂阻害 / 生物活性物質 / 海綿 / 海洋糸状菌 / ustiloxin / 抗ガン物質 / 多剤耐性克服 / リベロマイシン / P-glycoprotein / biological response modifier / enantio-dependence / bidirectional regulation / cell type / thalidomide / cytokine / phthalimide / tumor necrosis factor / 生物応答調節剤 / 医薬品化学 / 光学異性体 / 2方向性調節 / 光学活性依存性 / 生物学的応答調節剤 / 細胞種 / サリドマイド / サイトカイン / フタルイミド / 腫瘍壊死因子 / MRSA / MDR modifier / mechanism of MDR / tubulin / antitumor / multidrug-resistance / natural products / 耐性菌 / 耐性克服物質 / 薬剤耐性発現機構 / チューブリン / P-糖蛋白質 / 多剤耐性 / 天然物 / tumor promoter / receptor / nucleic acid / affinity labeling / porphyrin / retinoid / intercalator / dextran / ヘミン / 水溶性ポリマー / 塩基選択性 / ジヌクレオチド / インターカレーション / 分子認識 / 発癌プロモーター / 受容体 / 核酸 / アフィニティーラベル / ポルフィリン / レチノイド / インターカレーター / デキストラン / ION CHANNEL FORMATION / GP120-CD4 BINDING INHIBITION / MICROTUBULE ASSEMBLY INHIBITION / ANTITUMOR ACTIVITY / IMMUNOSUPPRESSIVE ACTIVITY / BIOFUNCTIONAL CONTROL / MICROORGANISM PRODUCT / DRUG DEVELOPMENTAL RESEARCH / イオン輸送 / 抗微小管活性 / 不完全菌 / 放線菌 / 担子菌 / 子のう菌 / 不斉合成 / イオンチャネル形成機構 / 緑膿菌薬剤耐性阻害活性 / gp120-CD4結合阻害活性 / 微小管機能制御活性 / 微生物由来薬品開発 / 生体機能制御活性 / イオンチャンネル形成 / GP120-CD4結合阻害 / 免疫抑制活性 / 生体機能制御 / 微生物生産物 / 医薬品開発研究 / ベラパミール / Epiderstatin / カンプトテシンのヒドロキシ高級脂肪酸エステル / アンスラサイクリンのモルホリノ誘導体 / CPT-11 / 細胞周期特異的抗腫瘍性 / O2-3D / クロモマイシン / 殺細胞活性 / ホヤ / エポキシド基 / がん / 血管新生病 / 血管新生 / 微生物代謝産物 / 抗真菌 / 群体ホヤ / enamidonin / nostodione A / isojaspisin / jaspisin / menoxymycin / cororubicin / tryprostatin / acetophthalidin / UK-1 / 紅花 / albuside A / arenastatin A / anguinomycin / 抗癌物質 / チューブリンへの作用 / アデノウイルス癌遺伝子 / di-n-buty1 malate / サイクロトリプロスタチン / スピロトリプロスタチン / curacin A / アポートシス / leptofuranin / resorcinin / 抗がん物質 / ヒストン脱アセチル化阻害剤 / trapoxin / malolactomycin / quinolidomicin / roseophilin / gilvocarcinの化学変換 / radicicol / reveromycin / ustiloxin A / JS49 / ホウ素含有化合物 / ギルボカルシンの化学変換 / ラジンコ-ル / ウスチロキシン / セコスリキサイド / 抗癌抗生物質 / 多剤耐性克服機構 / カンプトテシンアシル誘導体 / リゾキシンアシル誘導体 / ヒストンデアセチラ-ゼ阻害剤 / カプラマイシン誘導体 / ベントシアニン / epiderstatin / エトポシド / rhizoxin / 細胞周期特異的阻害剤 / leptomycin / gilvocarcin / lavanducyanin Less
  • Research Projects

    (27 results)
  • Co-Researchers

    (35 People)
  •  微小管機能を制御する超分子形成とリガンド機能の解析Principal Investigator

    • Principal Investigator
      岩崎 成夫
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  微生物代謝産物リゾキシンによる血管新生阻害の機構解析とその応用

    • Principal Investigator
      及川 勉
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  生物活性天然有機化合物の構造と機能

    • Principal Investigator
      浪越 通夫
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      東京水産大学
  •  STUDIES ON THE ANTIMITOTIC AGENTS-TUBULIN INTERACTION AND DRUG DESIGNPrincipal Investigator

    • Principal Investigator
      IWASAKI Shigeo
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      INSTITUTE OF MOLECULAR AND CELLULAR BIOSCIENCES,THE UNIVERSITY OF TOKYO
  •  微小管機能を制御する超分子形成とリガンド機能の解析Principal Investigator

    • Principal Investigator
      岩崎 成夫
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  生物活性物質の構造と機能

    • Principal Investigator
      浪越 通夫
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      東京水産大学
  •  Search and development for new compounds to overcome drug resistance from natural sources

    • Principal Investigator
      KOBAYASHI Jun'ichi
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Development of Phthalimide-type Novel Tumor Necrosis Factor (TNF) Production-regulators

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      THE UNIVERSITY OF TOKYO
  •  微小管機能を制御する超分子形成とリガンド機能の解析Principal Investigator

    • Principal Investigator
      岩崎 成夫
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  新規天然抗がん物質の探索

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  DEVELOPMENTAL RESEARCH TO UTILIZE MICROORGANISM PRODUCTS HAVING POTENCY OF BIOFUNCTIONAL CONTROL FOR DRUG MATERIALS

    • Principal Investigator
      YAMAZAKI Mikio
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      CHIBA UNIVERSITY
  •  Preparation of Functional Polylipid Biofactors

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      THE UNIVERSITY OF TOKYO
  •  新規構造を有する天然物由来抗癌物質に関する研究

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  リガンド分子設計によるチューブリンの薬物認識機構の解析Principal Investigator

    • Principal Investigator
      岩崎 成夫
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  Regulators of Microtubule Assembly : Molecular Recognition Mechanism and Developement of New Regulators.Principal Investigator

    • Principal Investigator
      IWASAKI Shigeo
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Institute of Molecular and Cellular Biosciences The University of Tokyo
  •  新規構造を有する天然物由来抗癌物質に関する研究

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  有糸分裂阻害剤-チューブリン間の精密構造認識の解析Principal Investigator

    • Principal Investigator
      岩崎 成夫
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  新規構造を有する天然物由来抗癌物質に関する研究

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  有糸分裂阻害剤ーチュ-ブリン分子間の精密構造認識の解析Principal Investigator

    • Principal Investigator
      岩崎 成夫
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Endiyne系抗腫瘍抗生物質クロモフォアの生合成の解析Principal Investigator

    • Principal Investigator
      岩崎 成夫
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      The University of Tokyo
  •  STUDY ON THE MICROBIAL METABOLITRES AS THE MEDICINAL RESOURCESPrincipal Investigator

    • Principal Investigator
      IWASAKI Shigeo
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      THE UNIVERSITY OF TOKYO
  •  天然物由来制癌物質の探索とその化学的誘導に関する研究

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  有糸分裂阻害剤ーチュ-ブリン分子間の精密構造認識の解析Principal Investigator

    • Principal Investigator
      岩崎 成夫
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  天然物由来制癌物質の探索とその化学的誘導に関する研究

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  天然物由来制癌物質の探索とその化学的誘導に関する研究

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  Bio-organic Studies on Inhibition of Tubulin Assembly by Mitosis InhibitorsPrincipal Investigator

    • Principal Investigator
      IWASAKI Shigeo
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Institute of Applied Microbiology, The University of
  •  Studies on Macrobial Metabolites Effective to Eucaryotic CellsPrincipal Investigator

    • Principal Investigator
      IWASAKI Shigeo, 奥田 重信
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      The University of Tokyo
  • 1.  HASHIMOTO Yuichi (90164798)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 2.  瀬戸 治男 (10013335)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 3.  長田 裕之 (80160836)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 4.  NAGAO Yoshimitsu (40027074)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 5.  SHIRAI Ryuichi (80183838)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 6.  MORISAKI Naoko (00092354)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  YAMAZAKI Mikio (70089598)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  NOZOE Shigeo (50013305)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  別府 輝彦 (80011873)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  大岳 望 (30013303)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  FUJITA Tetsuro (40027024)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  TSURUO Takashi (00012667)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  馬替 純二 (60199643)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  吉田 稔 (80191617)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  永井 和夫 (00011974)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  浪越 通夫 (30189196)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  NAKAGAWA Akira (60050548)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  TANAKA Haruo (40118823)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  OHTA Tomihisa (50108560)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  KOBAYASHI Jun'ichi (90221241)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  YAMAMURA Shosuke (40076708)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  FUJI Kaoru (20027056)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  ITOKAWA Hideji (60057304)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  NAKAMURA Shoshiro (40013304)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  MIKAMI Yuzuru (40092100)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  FURUKAWA Jun (80111574)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  柿沼 勝巳 (90092543)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  内藤 幹彦 (00198011)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  小林 昭雄 (30115844)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  池上 晋 (80011980)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  及川 勉 (40120141)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  嶋村 真里子 (00124462)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  落合 正仁 (50127065)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  佐藤 良博 (20050726)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  奥田 重信 (30013296)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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