TAKEGUCHI Noriaki 竹口紀晃

Researcher Number	00019126
Affiliation *help	2002 – 2003 : 富山医科薬科大学, 副学長 1993 – 2001 : Toyama Meidcal and Pharmaceutical University Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 1998 : 富山医科歯科大学, 薬学部, 教授 1990 – 1991 : 富山医科薬科大学, 薬学部, 教授 1986 – 1988 : 富山医科薬科大学, 薬学部, 教授 1986 : 富山医薬大, 薬学部, 教授
Review Section/Research Field	Principal Investigator General physiology / Physical pharmacy / Biological Sciences Except Principal Investigator General physiology / General physiology / Biological Sciences
Keywords	Principal Investigator 胃酸分泌 / 塩素イオンチャネル / 胃プロトンポンプ / 細胞防御 / gastric acid secretion / プロトンポンプ阻害剤 / イオンポンプ / 下痢 / パッチクランプ法 / Cl^-チャネル … More Except Principal Investigator イオンチャネル / トランスポータ / ポンプ / トランスポーター / ion channel / CLC-5 / EP / 閃光架橋法 / 分子生物学 / gastric acid secretion / 膜小胞 / 抗がん剤耐性 / トロンボキサンA_2 / 心臓 / cloning / ATP / セチルコリン受容体 / 遺伝子発現 / 免疫組織染色 / 電気生理学 / イオン / 高分化腺癌 / Ca pump / クローニング / 筋小胞体 / water channel / チャンネル / プロトンポンプ / 糖尿病 / 脳 / 分子会合 / キャリア / 安定発現細胞 / 胃酸分泌 / シクロオキシゲナーゼ / トロンボキサン合成酵素 / proton pump / 胃ベシクル / transporter / 塩素イオン / chloride ion / 脂質平面膜 / 細管小胞 / リン酸化 / 胃酸分泌細胞 / 膜輸送体 / 再構成ベシクル / 胃プロトンポンプ / イオン輸送 / 水チャネル / 胃酸分泌機構 / molecular association / チャネル / 抗癌剤 / phosphorylation / カルシウムポンプ / 酵素活性 / 大腸がん / 構造・機能相関 / structure-function relation / トロンボキサンレセプター Less

Novel physiological function of CLC-5 chloride channel associated with gastric proton pump
- Principal Investigator
  
  SAKAI Hideki
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  University of Toyama
  Toyama Medical and Pharmaceutical University
Structure and function of novel pumps and channels in gastrointestinal tractPrincipal Investigator
- Principal Investigator
  
  TAKEGUCHI Noriaki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
大腸がん発症とトロンボキサンレセプター遺伝子発現異常の連関の分子生理学的研究
- Principal Investigator
  
  酒井秀紀
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Toyama Medical and Pharmaceutical University
Molecular and functional relations and intracellular polarized movement of the functional molecules in stomach and intestine.Principal Investigator
- Principal Investigator
  
  SAKAI Hideki, 竹口紀晃
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Toyama Medical and Pharmaceutical University
化学療法剤による下痢発症機構と下痢抑制剤併用療法の基礎Principal Investigator
- Principal Investigator
  
  竹口紀晃
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Toyama Medical and Pharmaceutical University
フリッパーゼの機能-膜融合・細胞防御・時計側機能の可能性Principal Investigator
- Principal Investigator
  
  竹口紀晃
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Toyama Medical and Pharmaceutical University
The recognition and transport mechanism of ions in the proton pump and its intracellular transportPrincipal Investigator
- Principal Investigator
  
  TAKEGUCHI Noriaki
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General physiology
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
化学療法剤による下痢発症機構と下痢抑制剤併用療法の基礎Principal Investigator
- Principal Investigator
  
  竹口紀晃
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Toyama Medical and Pharmaceutical University
細胞防御クロライドイオンチヤネルのGTP結合蛋白による調節Principal Investigator
- Principal Investigator
  
  竹口紀晃
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Toyama Medical and Pharmaceutical University
ATP駆動型トランスポータとチャネルの構造・機能協関
- Principal Investigator
  
  UEDA Kazumitsu
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Channel-Transporter Correlation
- Principal Investigator
  
  OKADA Yasunobu
- Project Period (FY)
  1995 – 1998
- Research Category
  
  重点領域研究
- Research Institution
  Okazaki National Research Institutes
Electrophysiological study of the mechanism of diarrhea induced by camptothecin derivativePrincipal Investigator
- Principal Investigator
  
  TAKEGUCHI Noriaki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
細胞防御クロライドイオンチャネルのGTP結合蛋白による調節Principal Investigator
- Principal Investigator
  
  竹口紀晃
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Toyama Medical and Pharmaceutical University
イオンチャネルと担体型トランスポーターの構造的・機能的協関
- Principal Investigator
  
  OKADA Yasunobu
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  General physiology
- Research Institution
  Okazaki National Research Institutes
Malfunction of liver and intestine ion channels in mutant ratsPrincipal Investigator
- Principal Investigator
  
  TAKEGUCHI Noriaki
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Toyama Medical and Pharmaceutical University
Physiological study of Cl^- channels associated with gastric proton pump and liver multidrug efflux pumpPrincipal Investigator
- Principal Investigator
  
  TAKEGUCHI Noriaki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
Function, structure and regulation of two kinds of Cl^- channels involved in gastric acid secretionPrincipal Investigator
- Principal Investigator
  
  TAKEGUCHI Noriaki
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Toyama Medical and Pharmaceutical University
H、K-ATPaseの高次構造Principal Investigator
- Principal Investigator
  
  竹口紀晃
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Toyama Medical and Pharmaceutical University
Studies of function of epithelial transport in single cellsPrincipal Investigator
- Principal Investigator
  
  TAKEGUCHI Noriaki
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  General physiology
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
膜における情報変換分子の作動機構
- Principal Investigator
  
  葛西道生
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Osaka University
Immuno-electrophysiologgy on ion channels in gastric secretory cellsPrincipal Investigator
- Principal Investigator
  
  TAKEGUCHI Horiaki
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  TOYAMA MEDICAL AND PHAEMACEUTICAL UNIVERSITY

All 2005 2004 2002 2000

All Journal Article

[Journal Article] Novel molecular mechanisms of gastric phospholipids translocation activity in isolated hog gastric vesicles.2005
- Author(s)
  Morii M, Sakai H, Takeguchi N.
- Journal Title
  
  Membrane 30巻・6号
  
  Pages : 312-317
- Data Source
  KAKENHI-PROJECT-15390062
[Journal Article] Effects of the anti-cancer drug gefitinib on Cl^- secretion in isolated rat colon.2005
- Author(s)
  Ohkura J, Yamazaki H, Oyama Y, Morii M, Takeguchi N, Sakai H.
- Journal Title
  
  J.Pharm.Soc.Jpn. 125巻
  
  Pages : 50-51
- Data Source
  KAKENHI-PROJECT-15390062
[Journal Article] Cyclic AMP-dependent Cl^- secretion induced by thromboxane A_2 in isolated human colon.2005
- Author(s)
  Horikawa N, Suzuki T, Uchiumi T, Minamimura T, Tsukada K, Takeguchi N, Sakai H.
- Journal Title
  
  Journal of Physiology(London) 562巻3号
  
  Pages : 885-897
- Data Source
  KAKENHI-PROJECT-15390062
[Journal Article] Cyclic AMP-dependent Cl^- secretion induced by thromboxane A_2 in isolated human colon.2005
- Author(s)
  Horikawa N, Suzuki T, Uchiumi T, Minamimura T, Tsukada K, Takeguchi N, Sakai H.
- Journal Title
  
  Journal of Physiology (London) 562巻3号
  
  Pages : 885-897
- Data Source
  KAKENHI-PROJECT-12144205
[Journal Article] Up-regulation of Na^+,K^+-ATPase α3-isoform and down-regulation of the α1-isoform in human colorectal cancer.2004
- Author(s)
  Sakai H, Suzuki T, Maeda M, Takahashi Y, Horikawa N, Minamimura T, Tsukada K, Takeguchi N.
- Journal Title
  
  FEBS Letters 563巻1-3号
  
  Pages : 151-154
- Data Source
  KAKENHI-PROJECT-15390062
[Journal Article] Is the ClC-2 chloride channel involved in the Cl^- secretory mechanism of gastric parietal cells?2004
- Author(s)
  Hori K, Takahashi Y, Horikawa N, Furukawa T, Tsukada K, Takeguchi N, Sakai H.
- Journal Title
  
  FEBS Letters 575巻1-3号
  
  Pages : 105-108
- Data Source
  KAKENHI-PROJECT-15390062
[Journal Article] The cavity structure for docking the K^+-competitive inhibitors in the gastric proton pump.2004
- Author(s)
  Asano S, Yoshida A, Yashiro H, Kobayashi Y, Morisato A, Ogawa H, Takeguchi N, Morii M.
- Journal Title
  
  Journal of Biological Chemistry 279巻14号
  
  Pages : 13968-13975
- Data Source
  KAKENHI-PROJECT-12144205
[Journal Article] Up-regulation of Na^+, K^+-ATPase α3-isoform and down-regulation of the α1-isoform in human colorectal cancer.2004
- Author(s)
  Sakai H, Suzuki T, Maeda M, Takahashi Y, Horikawa N, Minamimura T, Tsukada K, Takeguchi N.
- Journal Title
  
  FEBS Letters 563巻1-3号
  
  Pages : 151-154
- Data Source
  KAKENHI-PROJECT-12144205
[Journal Article] Is the ClC-2 chloride channel involved in the Cl^- secretory mechanism of gastric parietal cells?2004
- Author(s)
  Hori K, Takahashi Y, Horikawa N, Furukawa T, Tsukada K, Takeguchi N, Sakai H.
- Journal Title
  
  FEBS Letters 575巻1-3号
  
  Pages : 105-108
- Data Source
  KAKENHI-PROJECT-12144205
[Journal Article] Expression of ATP1AL1, a non-gastric proton pump, in human colorectum.2002
- Author(s)
  Takahashi Y, et al.Tsukada K, Asano S, Takeguchi N
- Journal Title
  
  Jpn J Physiol 52
  
  Pages : 317-321
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12144205
[Journal Article] Establishment and characterization of a colonic epithelial cell line MCE301 from transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene.2000
- Author(s)
  Tabuchi Y, et al., Furusawa M, Obinata M, Fuse H, Takeguchi N, Asano S
- Journal Title
  
  Cell Struct Funct 25
  
  Pages : 297-307
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12144205

1. SAKAI Hideki (60242509)

# of Collaborated Projects : 9results

# of Collaborated Products : 11results
2. ASANO Shinji (90167891)

# of Collaborated Projects : 7results

# of Collaborated Products : 0results
3. IMAI Masashi (40049010)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
4. MORII Magotoshi (60019130)

# of Collaborated Projects : 3results

# of Collaborated Products : 1results
5. 五十里彰

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
6. OKADA Yasunobu (10025661)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. UEDA Kazumitsu (10151789)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
8. HOSHI Takeshi (60004537)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. MARUMO Fumiaki (00050443)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. TSUCHIYA Tomofusa (80012673)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. HATANAKA Yasumaru (30111181)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. TASHIRO Yutaka (40077558)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. NISHIYAMA Akinori (90004556)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. KANNO Tomuo (50009982)

# of Collaborated Projects : 1results

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15. 野間昭典 (00132738)

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16. 北里宏 (20079700)

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17. 山岸俊一 (70014032)

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18. 堀江稔 (90183938)

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19. 倉智嘉久 (30142011)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. 赤池紀生 (30040182)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. 秋山伸一 (60117413)

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22. 鈴木裕一 (50091707)

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23. 内藤幹彦 (00198011)

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24. 田内克典 (60260551)

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25. 葛西道生 (40022595)

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26. 加茂直樹 (10001976)

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27. 今栄康雄 (70022712)

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28. 曽我部正博 (10093428)

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29. DIENER Martin

# of Collaborated Projects : 1results

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TAKEGUCHI Noriaki 竹口 紀晃

Research Projects

Research Products

Co-Researchers

Novel physiological function of CLC-5 chloride channel associated with gastric proton pump

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structure and function of novel pumps and channels in gastrointestinal tractPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

大腸がん発症とトロンボキサンレセプター遺伝子発現異常の連関の分子生理学的研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular and functional relations and intracellular polarized movement of the functional molecules in stomach and intestine.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

化学療法剤による下痢発症機構と下痢抑制剤併用療法の基礎Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

フリッパーゼの機能-膜融合・細胞防御・時計側機能の可能性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The recognition and transport mechanism of ions in the proton pump and its intracellular transportPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

化学療法剤による下痢発症機構と下痢抑制剤併用療法の基礎Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

細胞防御クロライドイオンチヤネルのGTP結合蛋白による調節Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ATP駆動型トランスポータとチャネルの構造・機能協関

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Channel-Transporter Correlation

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Electrophysiological study of the mechanism of diarrhea induced by camptothecin derivativePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞防御クロライドイオンチャネルのGTP結合蛋白による調節Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

イオンチャネルと担体型トランスポーターの構造的・機能的協関

Principal Investigator

Project Period (FY)

Research Category

TAKEGUCHI Noriaki 竹口紀晃