SHIMIZU Akira 清水章

Researcher Number	00028581
Other IDs
Affiliation *help	2008 : 大阪医大, 名誉教授 2006 : Osaka Medical College, Faculty of Medicine, Emeritus Professor, 医学部, 名誉教授 1996 – 2005 : 大阪医大, 医学部, 教授 1992 – 2005 : Osaka Medical College, Clinical Pathol., Prof., 医学部, 教授 1998 : 大阪医科大学, 医学部, 助教授
Research Field	Except Principal Investigator Laboratory medicine / Laboratory medicine / Circulatory organs internal medicine
Keywords	Except Principal Investigator 質量分析 / トランスサイレチン / HCV / DAF / 補体 / クリオグロブリン / mass spectrometry / PNH / C型肝炎 / Transfection … More

質量顕微鏡によるアミロイド組織内沈着分子プロフィル異常と線維形成阻止法の開発Principal Investigator
- Principal Investigator
  
  田窪孝行, 清水章
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Identifications of diagnostic biomarkers specific binding to soluble proteins of adenocarcinoma A 549 cell lines by an autoantibodiomics
- Principal Investigator
  
  NAKANISHI Toyofumi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Proteomics-based approach identifying autoantibodies in Behcet's disease
- Principal Investigator
  
  TAKEUCHI Toru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Analysis of modified structures of transthyretin, elucidation of disease etiology of amyloidosis and application to clinical laboratory testsPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Akira
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Elucidation of the fine structure and the generation process of modified proteins (sulfonate, nitroso, et al.) application to clinical laboratory testPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Akira
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Expression proteomics of angiogenesis-modulated factors in human vitreous humors derived from diabetic retinopathy
- Principal Investigator
  
  NAKANISHI Toyofumi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
トランスサイレチン関連アミロイドーシスにおける繊維化分子機構の解明
- Principal Investigator
  
  岸川匡彦
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Evaluation of viral infection and trace elements in the myocardium of patients with idioipathic dilated cardiomyopathy
- Principal Investigator
  
  FUJIOKA Shigekazu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka Medical College
B cell clone proliferated in HCV infection and V regeon structure of RF correlated to complement clod activationPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Akira
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
The quantification of ratios between apo to holo types of metal binding protein : a new indicator of the oxidative stress in cells
- Principal Investigator
  
  NAKANISHI Toyofumi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
神経疾患の原因となる変異蛋白質の質量分析による検出と構造決定および新診断法の確立
- Principal Investigator
  
  KISHIKAWA Masahiko
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Establishment and practical use of reference method for glyco-haemoglobin by mass spectrometryPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Akira
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
金被覆ミクロキャピラリーLC装着質量分析による癌特異ペプチドの超高感度構造決定
- Principal Investigator
  
  NAKANISHI Toyohumi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Elucidation of complement cold activation and cryoglobulin formation associated with HCV infection.Principal Investigator
- Principal Investigator
  
  SHIMIZU Akira
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Study of the mechanism of in-vitro activation of complement and formation of cryoglobulin in the sera from patients with C type hepatitisPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Akira
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Mechanisms involved in loss of PI-anchored proteins (DAF and CD59) in human leukemia cell lines.
- Principal Investigator
  
  HATANAKA Michiyo
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College
Studies on the mechanisms of C9 activation and of C9 inactivation by the regulatory protein(MACIF)
- Principal Investigator
  
  HATANAKA Michiyo
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical College

All 2006 2005 2004 Other

All Journal Article

[Journal Article] Detection and characterization of variant and modified structures of proteins in blood and tissues by mass spectrometry.2006
- Author(s)
  Shimizu A, Nakanishi T, et al.
- Journal Title
  
  Mass Spectrom Rev 25
  
  Pages : 686-686
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590502
[Journal Article] Detection and characterization of variant and modified structures of proteins in blood and tissues by mass spectrometry.2006
- Author(s)
  Shimizu A, Nakanishi T, Miyazaki A.
- Journal Title
  
  Mass Spectrom Rev. 25
  
  Pages : 686-712
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590502
[Journal Article] Proteomic-based approach identifying autoantibody against peroxiredoxin IV as a novel serum marker in esophageal squamous cell carcinoma.2006
- Author(s)
  Fujita Y, Nakanishi T, Hiramatsu M, Mabuchi H, Miyamoto Y, Miyamoto A, Shimizu A, Tanigawa N.
- Journal Title
  
  Clin.Cancer Res. 12・21
  
  Pages : 6415-6420
- Data Source
  KAKENHI-PROJECT-17590501
[Journal Article] Proteomic-based approach identifying autoantibody against peroxiredoxin VI as a novel serum marker in esophageal squamous cell carcinoma.2006
- Author(s)
  Fujita Y, Nakanishi T, Hiramatsu M, Mabuchi H, Miyamoto Y, Miyamoto A, Shimizu A, Tanigawa N
- Journal Title
  
  Clin. Cancer Res. 12・21
  
  Pages : 6415-6420
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590501
[Journal Article] Detection of eight antibodies in cancer patients' sera against proteins derived from the adenocarcinoma A549 cell line using proteomics-based analysis.2006
- Author(s)
  Nakanishi T, Takeuchi T, Ueda K, Murao H, Shimizu A.
- Journal Title
  
  J Chromatogr B Analyt Technol Biomed Life Sci 838(1)
  
  Pages : 15-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590501
[Journal Article] Proteomic-based approach identifying autoantibody against peroxiredoxin VI as a novel serum marker in esophageal squamous cell carcinoma.2006
- Author(s)
  Fujita Y, Nakanishi T, Hiramatsu M, Mabuchi H, Miyamoto Y, Miyamoto A, Shimizu A, Tanigawa N.
- Journal Title
  
  Clin.Cancer Res. 12(21)
  
  Pages : 6415-6420
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590501
[Journal Article] Detection of eight antibodies in cancer patients' sera against proteins derived from the adenocarcinoma A549 cell line using proteomics-based analysis.2006
- Author(s)
  Nakanishi T, Takeuchi T, Ueda K, Murao H, Shimizu A.
- Journal Title
  
  J Chromatogr B 838
  
  Pages : 15-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590502
[Journal Article] Detection of eight antibodies in cancer patients' sera against proteins derived from the adenocarcinoma A549 cell line using proteomics-based analysis.2006
- Author(s)
  Nakanishi T, Takeuchi T, Ueda K, Murao H, Shimizu A
- Journal Title
  
  J Chromatogr B Analyt Technol Biomed Life Sci 838・1
  
  Pages : 15-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590501
[Journal Article] Hb KOCHI [β141(H19)Leu→Val (g.1404 C→G);144-146(HC1-3)Lys-Tyr-His→0(g.1413 A→T)]:A NEW VARIANT WITH INCREASED OXYGEN AFFINITY.2005
- Author(s)
  Ayako Miyazaki, Toyofumi Nakanishi, Akira Shimizu, Miki Mizobuchi, Yasuhiro Yamada, Kiyohiro Imai:
- Journal Title
  
  Hemoglobin 29・1
  
  Pages : 1-10
- Data Source
  KAKENHI-PROJECT-17590501
[Journal Article] Rapid disease progression correlates with instability of mutant SOD1 in familial ALS.2005
- Author(s)
  T Sato, T Nakanishi, Y Yamamoto, PM Andersen, Y Ogawa, K Fukada, Z Zhou, F Aoike, F Sugai, S Nagano, S Hirata, M Ogawa, R Nakano, T Ohi, T Kato, M Nakagawa, T Hamasaki, A Shimizu, S Sakoda
- Journal Title
  
  Neurology 65(12)
  
  Pages : 1954-1957
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590466
[Journal Article] Hb KOCHI[β141(H19)Leu→Val (g.1404 C→G) ; 144-146(HC1-3)Lys-Tyr-His→0(g.1413 A→T)] :A NEW VARIANT WITH INCREASED OXYGEN AFFINITY.2005
- Author(s)
  A Miyzai, T Nakanishi, A Shimizu, M Mizobuchi, Y Yamada, K Imai
- Journal Title
  
  Hemoglobin 29・1
  
  Pages : 1-10
- Data Source
  KAKENHI-PROJECT-16590466
[Journal Article] Rapid disease progression correlates with instability of mutant SOD1 in familial ALS.2005
- Author(s)
  T Sato, T Nakanishi, Y Yamamoto, PM Andersen, Y Ogawa, K Fukada, Z Zhou, F Aoike, F Sugai, S Nagano, S Hirata, M Ogawa, R Nakano, T Ohi, T Kato, M Nakagawa, T Hamasaki, A Shimizu, S Sakoda
- Journal Title
  
  Neurology 65・12
  
  Pages : 1954-1957
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590466
[Journal Article] Hb KOCHI [β141(H19)Leu→Val (g.1404 C→G) ; 144-146(HC1-3)Lys-Tyr-His→0 (g.1413 A→T)] : A NEW VARIANT WITH INCREASED OXYGEN AFFINITY.2005
- Author(s)
  A Miyazaki, T Nakanishi, A Shimizu, M Mizobuchi, Y Yamada, K Imai
- Journal Title
  
  Hemoglobin 29(1)
  
  Pages : 1-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590466
[Journal Article] Hb KOCHI [β141(H19)Leu→Val (g.1404 C→G); 144-146(HC1-3)Lys-Tyr-His→O (g.1413 A→T)] : A NEW VARIANT WITH INCREASED OXYGEN AFFINITY.2005
- Author(s)
  A Miyazaki, T Nakanishi, A Shimizu, M Mizobuchi, Y Yamada, K Imai
- Journal Title
  
  Hemoglobin 29・1
  
  Pages : 1-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590466
[Journal Article] Effect of mutated transporters associated with antigen-processing 2 on characteristic major histocompatibility complex binding peptides : analysis using electrospray ionization tandem mass spectrometry.2004
- Author(s)
  G.Kageyama, S.Kawano, S.Kanagawa, S.Kondo, M.Sugita, T.Nakanishi, A.Shimizu, S.Kumagai
- Journal Title
  
  Rapid Communications in Mass Spectrometry 18
  
  Pages : 955-1000
- Data Source
  KAKENHI-PROJECT-16590466
[Journal Article] Identification of two novel mutations in the Cu/Zn superoxide dismutase gene with familial amyotrophic lateral sclerosis : mass spectrometric and genomic analyses.2004
- Author(s)
  Sato T, Yamamoto Y, Nakanishi T, Fukada K, Sugai F, Zhou Z, Okuno T, Nagano S, Hirata S, Shimizu A, Sakoda S
- Journal Title
  
  J Neurol Sci 218(1-2)
  
  Pages : 79-83
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590466
[Journal Article] New approaches towards laboratory diagnosis of isolated sulfite oxidase deficiency2004
- Author(s)
  J.O.Sass, T Nakanishi, T Sato, A Shimizu
- Journal Title
  
  Annals of Clinical Biochemistry 41
  
  Pages : 157-159
- Data Source
  KAKENHI-PROJECT-16590466
[Journal Article] Modification of cysteine residue in transthyretin and a synthetic peptide, analyses by electrospray ionization mass spectrometry.2004
- Author(s)
  T Nakanishi, T Sato, S Sakoda, M Yoshioka, A Shimizu
- Journal Title
  
  Biochimica et Biophysica Acta 1698
  
  Pages : 45-53
- Data Source
  KAKENHI-PROJECT-16590466
[Journal Article] Effect of mutated transporters associated with antigen-processing 2 on characteristic major histocompatibility complex binding peptides : analysis using electrospray ionization tandem mass spectrometry.2004
- Author(s)
  G.Kageyama, S.Kawano, S.Kanagawa, S.Kondo, M.Sugita, T.Nakanishi, A.Shimizu, S.Kumagai
- Journal Title
  
  Rapid Communications in Mass Spectrometry 18
  
  Pages : 995-1000
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590466
[Journal Article] Identification of two novel mutations in the Cu/Zn superoxide dismutase gene with familianl amyotrophic lateral sclerosis : mass spectrometric and genomic analyses.2004
- Author(s)
  Sato T, Yamamoto Y, Nakanishi T, Fukada K, Sugai F, Zhou Z, Okuno T, Nagano S, Hirata S, Shimizu A, Sakoda S
- Journal Title
  
  J Neurol Sei 218(1-2)
  
  Pages : 79-83
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590466
[Journal Article] Development of an isotope-dilution mass spectrometric assay for HbA1c based on enzyme-cleaved peptide analysis.2004
- Author(s)
  K Iguchi, T Nakanishi, A Miyazaki, A Shimizu, A Ota
- Journal Title
  
  Journal of Chromatography B 806
  
  Pages : 25-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590466
[Journal Article] Detection and characterization of variant and modified structures of proteins in blood and tissues by mass spectrometry
- Author(s)
  Akira Shimizu, Toyofumi Nakanishi, Ayako Miyazaki
- Journal Title
  
  Mass Spectrometry Review (in press)
- Data Source
  KAKENHI-PROJECT-17590501
[Journal Article] Serum Protein Profile of Rheumatoid Arthritis Treated with Anti-TNF therapy (Infliximab).
- Author(s)
  Takeuchi T, Nakanishi N, Tabushi Y, Hata A, Shoda T, Kotani T, Shimizu A, Takubo T, Makino S, Hanafusa T.
- Journal Title
  
  J Chromatogr B (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590502
[Journal Article] Detection and characterization of variant and modified structures of proteins in blood and tissues by mass spectrometry.
- Author(s)
  Akira Shimizu, Toyofumi Nakanishi, Ayako Miyazaki
- Journal Title
  
  Mass Spectrometry Reviews (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590466
[Journal Article] Detection and characterization of variant and modified structures of proteins in blood and tissues by mass spectrometry.
- Author(s)
  Akira Shimizu, Toyofumi Nakanishi, Ayako Miyazaki
- Journal Title
  
  Mass Spectrometry Reviews (in press)
- Data Source
  KAKENHI-PROJECT-16590466
[Journal Article] Detection and characterization of variant and modified structures of proteins in blood and tissues by mass spectrometry.
- Author(s)
  Akira Shimizu, Toyofumi Nakanishi, Ayako Miyazaki
- Journal Title
  
  Mass Spectrometry Reviews (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590466

1. NAKANISHI Toyohumi (10247843)

# of Collaborated Projects : 14results

# of Collaborated Products : 26results
2. KISHIKAWA Masahiko (40268199)

# of Collaborated Projects : 5results

# of Collaborated Products : 0results
3. NAKAGAWA Toshimasa (30237226)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
4. HATANAKA Michiyo (50218484)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
5. MIYAZAKI Ayako (20298772)

# of Collaborated Projects : 3results

# of Collaborated Products : 6results
6. TAKEUCHI Toru (10330078)

# of Collaborated Projects : 2results

# of Collaborated Products : 4results
7. FUJIOKA Shigekazu (20319528)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. DEGUCHI Hirofumi (90131341)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. KITAURA Yasushi (50084950)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. UKIMURA Akira (50257862)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. IKEDA Tsunehiko (70222891)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. MURAO Hitoshi (00278540)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
13. GOTO Isao (90330084)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. 田窪孝行 (60163359)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. 稲井真弥 (90131317)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. SEYA Tsukasa

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. YAGI Masayuki

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

SHIMIZU Akira 清水 章

Research Projects

Research Products

Co-Researchers

質量顕微鏡によるアミロイド組織内沈着分子プロフィル異常と線維形成阻止法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of modified structures of transthyretin, elucidation of disease etiology of amyloidosis and application to clinical laboratory testsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the fine structure and the generation process of modified proteins (sulfonate, nitroso, et al.) application to clinical laboratory testPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

B cell clone proliferated in HCV infection and V regeon structure of RF correlated to complement clod activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment and practical use of reference method for glyco-haemoglobin by mass spectrometryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of complement cold activation and cryoglobulin formation associated with HCV infection.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

SHIMIZU Akira 清水章