OTSUKI Makoto 大槻眞

… Alternative Names

大槻眞オオツキマコト

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Researcher Number	00030916
Other IDs
Affiliation (based on the past Project Information) *help	2008: 産業医科大学, 医学部, 名誉教授 1998 – 2008: 産業医科大学, 医学部, 教授 1995 – 1996: 産業医科大学, 医学部, 教授 1989: 神戸大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology
Keywords	Principal Investigator mRNA / survivin / 消化管ホルモン / 膵癌 / インスリン結合 / 蛋白キナ-ゼC / 膵炎 / 線維化 / 細胞外基質 / TGF-β … More / 慢性膵炎 / 膵線維化 / アルギニン膵炎 / オレイン酸膵炎 / Pancreatitis / Fibrosis / Extracellular Matrix / TGF-beta / OLETFラット / トランスジェニック / CCK-A受容体 / ノックアウトラット / OLETF rat / transgenic rat / CCK-A receptor / 急性膵炎 / アポトーシス / 抗アポトーシス / 再生 / 細胞増殖 / nineteen kD interacting protein-3 like protein / 出血性壊死性膵炎 / 膵炎後肺障害 / differential display / 膵管上皮細胞 / 膵腺房細胞 / Survivin / 膵管細胞 / 腺房細胞 / acute pancreatitis / apoptosis / antiapoptotic effect / regeneration / proliferation … More Except Principal Investigator 慢性膵炎 / TGF-beta / TGF-β / Smad6 / matrix metalloproteinase / 胃食道逆流症 / チューインガム / 膵線維化 / トランスジェニックマウス / Smad / 膵再生 / Smad3 / 膵外分泌 / ペースメーカー機構 / トランスジェーニック / トランスジェ-ニック / transgenic mouse / fibrosis / 機能性ディスペプシア / レプチン / コレシストキニン / Functional dyspepsia / Leptin / Cholecystokinin / 肝硬変 / 耐糖能障害 / 治療 / 肝癌 / 肝線維化 / 耐糖能異常 / Liver cirrhosis / Diabetes Mellitus / Treatment / エンドセリン / 膵繊維化 / 線維化 / 繊維化 / Chronic Pancreatitis / Endothelin / Fibrosis / アルコール性膵障害 / 膵星細胞 / 抗酸化剤 / 緑茶ポリフェノール / 恒久的胃瘻モデルラット / 膵腺房細胞 / alcohol-related pancreatic injury / pancreatic stellate cells / antioxidant Less

Chewing bicarbonate-containing gum as a treatment option for gastroesophageal reflux disease
- Principal Investigator
  
  YOSHIKAWA Ichiro
- Project Period (FY)
  2005 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Occupational and Environmental Health, Japan
Elucidation of pathological mechanism of the pancreatic fibrosis in chronic pancreatitis.
- Principal Investigator
  
  NAKAMURA Hayato
- Project Period (FY)
  2005 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Occupational and Environmental Health, Japan
膵外分泌ペースメーカー機構の解明
- Principal Investigator
  
  山本光勝
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  University of Occupational and Environmental Health, Japan
Strategy of treatment for diabetes mellitus with liver cirrhosis
- Principal Investigator
  
  TABARU Akinari
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Occupational and Environmental Health, Japan
Gene Therapy of Chronic Pancreatitis by Antisense Endothelin and Variant-type Endothelin Receptors
- Principal Investigator
  
  KIHARA Yasuyuki
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Occupational and Environmental Health, Japan
Pathophysiology of alcohol-related pancreatic injury
- Principal Investigator
  
  TASHIRO Mitsuo
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Occupational and Environmental Health, Japan
Apoptosis and anti-apoptosis in pancreatic diseasesPrincipal Investigator
- Principal Investigator
  
  OTSUKI Makoto
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Occupational and Environmental Health, Japan
Role of gastric leptin and cholecystokinin in patients with functional dyspepsia
- Principal Investigator
  
  YOSHIKAWA Ichiro
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Occupational and Environmental Health
Pancreatic fibrosis and diabetes in transgenic OLETF rat expressing CCK-A receptor
- Principal Investigator
  
  NAKAMURA Makoto
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Occupational and Environmental Health
Pancreatic fibrosis and diabetes in transgenic OLETF rat expressing CCK-A receptorPrincipal Investigator
- Principal Investigator
  
  OTSUKI Makoto
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Gastroenterology
- Research Institution
  University of Occupational and Environmental Heath
Role of extracellular matrix, cytokines and gut hormones on pancreatic fibrosis in arginine-induced pancreatitis.Principal Investigator
- Principal Investigator
  
  OTSUKI Makoto
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Occupational and Environmental Health
膵癌細胞増殖における特異的遺伝子発現に対する膵ホルモン及び消化管ホルモンの作用Principal Investigator
- Principal Investigator
  
  大槻眞
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kobe University

All 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Increased expression of Smad6 deteriorates murine acute experimental pancreatitis in two models.2008
- Author(s)
  Nakamura H, Tashiro M, Asaumi H, Nomiyama Y, Kaku M, Watanabe S, Miyamoto T, Otsuki M.
- Journal Title
  
  Gut. 57(6)
  
  Pages: 788-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590691
[Journal Article] Preferential increase of extracellular matrix expression relative to transforming growth factor beta1 in the pancreas during the early stage of acute hemorrhagic pancreatitis in rats.2007
- Author(s)
  Nakamura H, Tashiro M, Yamaguchi T, Asaumi H, Nomiyama Y, Watanabe S, Nagashio Y, Miyamoto T, Otsuki M.
- Journal Title
  
  Pancreas. 35(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590691
[Journal Article] High glucose activates rat pancreatic stellate cells through protein kinase C and p38 mitogen-activated protein kinase pathway.2007
- Author(s)
  Nomiyama Y, Tashiro M, Yamaguchi T, Watanabe S, Taguchi M, Asaumi H, Nakamura H, Otsuki M.
- Journal Title
  
  Pancreas. 34(3)
  
  Pages: 364-72
- NAID
  10024366871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590691
[Journal Article] Green tea polyphenol(-)-epigallocatechin-3-gallate inhibits ethanol-induced activation of pancreatic stellate cells.2006
- Author(s)
  Asaumi H, Watanabe S, Taguchi M, Tashiro M, Nagashio Y, Nomiyama Y, Nakamura H, Otsuki M.
- Journal Title
  
  M. Eur J Clin Invest. 36(2)
  
  Pages: 113-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590691
[Journal Article] Persistent destruction of the basement membrane of the pancreatic duct contributes to progressive acinar atrophy in rats with experimentally induced pancreatitis.2005
- Author(s)
  Yamaguchi T, Kihara Y, Taguchi M, Nagashio Y, Tashiro M, Nakamura H, Otsuki M.
- Journal Title
  
  Pancreas. 31(4)
  
  Pages: 365-72
- NAID
  130004495719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590691
[Presentation] Increased Expression of Smad6 Deteriorates Murine Acute Pancreatitis.2008
- Author(s)
  Hayato Nakamura, Hiroshi Asaumi, Yoko Nomiyama, Shiro Watanabe and Makoto Otsuki.
- Organizer
  DDW2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-18
- Data Source
  KAKENHI-PROJECT-17590691
[Presentation] Increased expression of Smad6 deteriorates murine Acute edematous pancreatitis.2006
- Author(s)
  Nakamura H, Tashiro M, Asaumi H, Nomiyama Y, Watanabe S, Miyamoto T, Otsuki M.
- Organizer
  7th World Congress of the International Hepato-Pancreato-Biliary Association
- Place of Presentation
  Edinburgh, Scotland
- Year and Date
  2006-09-03
- Data Source
  KAKENHI-PROJECT-17590691
[Presentation] Smad6トランスジェニック・マウスにおけるアミラーゼ分泌反応と膵内トリプシン活性化.2005
- Author(s)
  中村早人, 角みどり, 田代充生, 大槻眞
- Organizer
  第36回日本膵臓学会大会
- Place of Presentation
  東京
- Year and Date
  2005-07-29
- Data Source
  KAKENHI-PROJECT-17590691
[Presentation] Smad6トランスジェニック・マウスにおけるaction dynamicsとアミラーゼ分泌反応2005
- Author(s)
  中村早人, 角みどり, 田代充生, 大槻眞
- Organizer
  第47回日本消化器病学会大会
- Place of Presentation
  神戸
- Year and Date
  2005-10-05
- Data Source
  KAKENHI-PROJECT-17590691

1. NAKAMURA Hayato (90207902)

# of Collaborated Projects: 5 results

# of Collaborated Products: 9 results
2. KIHARA Yosuyuki (80279330)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. TASHIRO Mitsuo (20341498)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
4. YOSHIKAWA Ichiro (60210655)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. AKIYAMA Toshiharu (10320350)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TAGUCHI Masashi (80369058)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KUME Keiichiro (20320351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TABARU Akinari (50188405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NARITA Ryoichi (30320352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 山本光勝 (10341497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 井本逸勢 (30258610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OTSUKI Makoto 大槻 眞

大槻 眞 オオツキ マコト

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Apoptosis and anti-apoptosis in pancreatic diseasesPrincipal Investigator

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Pancreatic fibrosis and diabetes in transgenic OLETF rat expressing CCK-A receptorPrincipal Investigator

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Role of extracellular matrix, cytokines and gut hormones on pancreatic fibrosis in arginine-induced pancreatitis.Principal Investigator

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膵癌細胞増殖における特異的遺伝子発現に対する膵ホルモン及び消化管ホルモンの作用Principal Investigator

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[Journal Article] Increased expression of Smad6 deteriorates murine acute experimental pancreatitis in two models.2008

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[Journal Article] Preferential increase of extracellular matrix expression relative to transforming growth factor beta1 in the pancreas during the early stage of acute hemorrhagic pancreatitis in rats.2007

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[Journal Article] High glucose activates rat pancreatic stellate cells through protein kinase C and p38 mitogen-activated protein kinase pathway.2007

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OTSUKI Makoto 大槻眞

大槻眞オオツキマコト