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WATANABE Keiichi  渡辺 慶一

ORCIDConnect your ORCID iD *help
Researcher Number 00055865
Affiliation (based on the past Project Information) *help 1989 – 1999: Professor of Dept. of Pathology, Tokai Univ., 医学部, 教授
1993 – 1995: Tokai University School of Medicine, Professor, 医学部・病理学, 教授
1993: Tokai Univ.pathology., proffesor, school Med., 医学部・病理, 教授
1991: Prof. of Dept. of Pathology, Tokai Univ. School of Med., 医学部・病理学教室, 教授
1987 – 1989: 東海大学, 医学部・病理, 教授 … More
1987 – 1989: Professor, Department of Pathology Tokai University School of Medicine, 医学部・病理学, 教授
1988: 東海大学, 医学部(病理学), 教授
1988: 東海大学, 医学部病理学教室, 教授
1987: Department of Pathology, Tokai University School of Medicine, 医学部・(病理学), 教授
1986: 東海大, 医学部, 教授
1986: 東海大学, 医学部, 教授
1985: 東海大学, 医, 教授 Less
Review Section/Research Field
Principal Investigator
Experimental pathology
Except Principal Investigator
Digestive surgery / 細菌学 / Human pathology / Experimental pathology
Keywords
Principal Investigator
脂質過酸化 / キノリン酸 / グルタチオンペルオキシダーゼ / diacylglycerol / 酸化ストレス / プロテインキナーゼC / 過酸化ジアシルグリセロール / ホルボールエステル / Cキナーゼ(PKC) / ホルボールエステル(PMA) … More / oxidative stress / ハンチントン病 / 神経細胞死 / グリア細胞 / グルタチオン・ペルオキシダ-ゼ / 線条体 / 神経細胞壊死 / グルタチオン・ペルオキシダーセ / ハンチントン病様病変 / 神経細胞 / Cキナーゼ / 神経原繊維 / 神経変性疾患 / ジアシルグリセロール(DAG) / 過酸化ジアシルグリセロール(DAG-OOH) / アルツハイマー病 / PC12細胞 / protein kinase c isoforms / lipid peroxidation / diacylglycerols / lipid mediators / microtubule degeneration / PMA / protein kinase C / neuronal cell death / signal transduction / 副腎皮質内側束状層 / ミトコンドリア内グルタチオンペルオキシダーゼ / ステロイド産生 / ACTH / ミトコンドリア内蛋白輸送 / 動脈硬化症 / マクロファージ / 中膜中滑筋細胞 / 泡沫細胞 / p^<53>蛋白 / 大腸腺腫内癌 / 点突然変異 / in situ PCR法 / 免疫組織化学 / 抗原体賦活化 / ホメオティック遺伝子 / Hox4B蛋白 / P^<53>蛋白 / 抗源性賦活化 / Hox4B / tumor banking system / 胃癌 / 乳癌 / polymerase chain reaction / 癌抑制遺伝子 / P^<53> / heat shock protein / p53 protein / colonic cancer in adenoma / point mutation / in situ PCR technique / immunohistochemistry / antigen retrieval / homeo box gene / Hox4B protein / diacylglycerol(DAG) / Oxidized diacylglycerol(DAG-OOH) / ホルポールエステル(PMA) / 培養神経細胞 / 微細管異常 / tau / map-2 / ジアシルグリセロール / イノシトールリン脂質 / ホスホリパーゼC / Protein Kinase C / Diacylglycerol / Oxidized diacylglycerol / Phorbol ester (PMA) / Alzheimer's disease / 新共焦点レーザー顕微鏡開発 / living cellsの微細構造 / 紫外線領域短波長レーザー / 工業用レーザー顕微鏡 / 縦軸、横軸分解能 / 共焦点レーザー顕微鏡 / 細胞内小器官 / 光顕 / 電顕 / 空間分解能 / ヘリウム-カドニウムレーザーHe-Cd / Confocal Laser Scanning Microscope / Fine structures living cells / Very short wave length laser / CLSM for engineering / Resolution power in vertical and horizontal axises / alkaline phophatase (AP) / embryonal AP / Tissue nonspecific AP / knock-out mice / alkaline phophatase(AP) / ALKALINE PHOSPHATASE (AP) / EMBRYONAL AP / TISSUE NONSPECIFIC AP / KOCK-OUT MICE / グルタチオン・ペルオキシダーゼ / 細胞傷害 / 肝脂肪変性 / 脂肪肝 / 【CCl_4】 / 蛋白合成阻害剤 / hyperplastic nodule(過形成性結節) / グルタチオンペルオキシダーゼ(GSH-PO)セレン(Se) / GSH-PO合成誘導機構 / ミトコンドリア内局在 / (GSH-POの)アミノ酸配列 / Lipid Peroxidation / Glutathione Peroxidase / Cell Injury … More
Except Principal Investigator
モノクローナル抗体 / 無菌マウス / ヒトの肺 / 染色体異常 / 細胞接着分子 / アドリアマイシン / 制癌剤 / Ex vivo / ネズミチフス菌 / 普通マウス / Kupffer細胞 / ルミノ-ル依存性化学発光 / Helicobacter pylori / diacylglycerol / protein kinase C / lipid peroxidation / signal transduction / glutathione peroxidase / DIACYLGLYCEROL / PROTEIN KINASE C / LIPID PEROXIDATION / SIGNAL TRANSDUCTION / GLUTATHIONE PEROXIDASE / 線癌 / 遺伝子異常 / 核DNAプロイディー / 基質糖蛋白 / 組織化学 / 免疫組織化学 / アドリアマイシン抗体 / 腺癌 / 遺伝子産物 / 核DNA / 普免マウス / MCLA依存性化学発光 / 肉芽腫性病変 / クッパ-細胞 / PMA / O^-_2 / ルシフェリン依存性化学発光 / ザイモサン / Kupffer cell / S. typhimurium / Intestinal bacterial flora / O_2 Production / Facultative intracellular parasite / Granulomatous lesion / Liver and spleen / 酵素抗原法 / 慢性萎縮性 / 腸上皮化生 / 特異抗原産生細胞 / リコンビナント蛋白 / マルトース結合蛋白 / 局所免疫 / 慢性萎縮性胃炎 / 分泌型IgA / Enzyme-labeled antigen method / Chronic atrophic gastiritis / Intestinal metaplasia / Antibody-producing cells / Recombinant protein / Maltose-binding protein / Mucosal immunity / 制癌剤抗体 / 耐性 / 抗アドリアマイシン / ポリクローナル抗体 / ADM / anti-ADM / anti-carcinostatic / monoclonal antibody / 抗制癌剤抗体 / 副作用 / 薬効作用 / anti cancer drug / antibody-anti cancer drug / side effect / daicylglycerol / oxidative stress / 連続流動培養 / C.difficile / CF培養 / 細胞毒活性作用 / Continuous floe culture / Clostridium difficile / モノクロ-ナル抗体 / モザイシズム / 多相性(Heterogeneity) / 癌 / 診断 / 治療 / モノクローナル複合体 / Monoclonal Antibody / Mosaicism / Heterogeneity / 甲状腺 / C細胞 / カルシトニン / 分泌調節 / 細胞動態 / カルシウム代謝 / CGRP / カルシトニン遺伝子関連ペプチド / 細胞内プロセシング / 遺伝子プロセシング / Thyroid Gland / C cell / Calcitonin / Secretion / Cell cycle / Calcium metabolism / GCRP / ルンフェリン依存性化学発光 / ミエロペルオキシダ-ゼ / ス-パ-オキサイド / 食細胞 / 網内系 / 肉芽腫 / 内在性ペルオキシダ-ゼ / 粗面小胞体 / 顆粒球 / 前単球 / 化学発光 / 活性酸素 / Superoxide anion / Germfree mice / Conventional mice / Myeloperoxidase Less
  • Research Projects

    (27 results)
  • Co-Researchers

    (31 People)
  •  過酸化ジアシルグリセロールの特殊なCキナーゼ活性化と神経細胞死Principal Investigator

    • Principal Investigator
      渡辺 慶一
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tokai University
  •  MOLECULAR MECHANISM FOR ALTERATION IN SIGNAL TRANSDUCTION BY OXIDATIVE STRESS -Isoform specific activation of C kinase by oxidized DAG and cell injury-

    • Principal Investigator
      TAKEKOSHI Susumu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokai University
  •  酸化ジアシルグリセロールのユニークなCキナーゼ活性化作用Principal Investigator

    • Principal Investigator
      渡辺 慶一
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  MICE LACKING ALKALINE PHOSPHATASE ISOZYMES.-MOLECULAR GENETICS AND PATHOLOGICAL INVESTIGATIONPrincipal Investigator

    • Principal Investigator
      WATANABE Keiichi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Experimental pathology
    • Research Institution
      TOKAI UNIVERSITY
  •  神経細胞変性・細胞死と脂質過酸化:〜酸化ジアシルグリセロールの生物学的機能と病理学的意義〜Principal Investigator

    • Principal Investigator
      渡辺 慶一
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  THE STUDY OF C KINASE ACTIVATOR CAUSE FOR THE PATHOLOGICAL CHANGES.

    • Principal Investigator
      TAKEKOSHI Susumu
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      2
  •  キノリン酸による神経細胞傷害における脂質過酸化の意義Principal Investigator

    • Principal Investigator
      渡辺 慶一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  Mechanisms of Protein Kinase C Activatic by Lipid Peroxidation and its Biological SignificancePrincipal Investigator

    • Principal Investigator
      WATANABE Keiichi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokai university
  •  Development of a New High Performance Confocal Laser Scanning Microscpe Enabling the Observation of Dynamic Changes of Subcellular Organelles.Principal Investigator

    • Principal Investigator
      WATANABE Keiichi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokai University
  •  キノリン酸による神経細胞障害にみる脂質過酸化とその障害機序の究明Principal Investigator

    • Principal Investigator
      渡辺 慶一
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  A STUDY OF THE EFFECTIVENESS OF A CARCINOSTATIC AND INCREASING GARCINOSTATIC TOLERANCE

    • Principal Investigator
      MITOMI Toshio
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Tokai University
  •  神経細胞の変性、壊死における脂質過酸化とその防御、修復因子の意義Principal Investigator

    • Principal Investigator
      渡辺 慶一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  Identification of cells producing antibodies specific for Helicobacter pylori in chronic atrophic gastritis : Application of the enzyme-labeled antigen method.

    • Principal Investigator
      TSUTSUMI Yutaka
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Tokai University School of Medicine
  •  A study of the effectiveness of a carcinostatic and increasing carcinostatic tolerance

    • Principal Investigator
      MITOMI Toshio
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Tokai Univ.School of Medicine, Dept.surg.II
  •  キノリン酸による脂質過酸化亢進とラット線条体神経細胞の変性、壊死:脂質過酸化修復因子(グルタチオン・ペルオキシダ-ゼ)の変動による病変の修飾Principal Investigator

    • Principal Investigator
      渡辺 慶一
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  DNA analysis on developmental anomalies and malignant tumors for the investigation on the mechanism of carcinogenesis.Principal Investigator

    • Principal Investigator
      WATANAVE Keiichi
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tokai University
  •  The role of intestinal flora in qualitative change of phagocytic cell response in experimental typhoid

    • Principal Investigator
      OZAWA Atsushi
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      細菌学
    • Research Institution
      Department of Microbiology, Tokai University, School of Medicine
  •  ヒト肺線癌の特性の分子病理学的解析

    • Principal Investigator
      下里 幸雄
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  ヒト肺腺癌の特性の分子病理学的解析

    • Principal Investigator
      下里 幸雄
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  Study of The Heterogeneity in Cancer by Monoclonal Antibodies

    • Principal Investigator
      NAKASAKI Hisao
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Department of 2nd Surgery. Tokai University, School of Medicine
  •  Synthesis and secretion of calcitonin and calcitonin gene-related peptide.

    • Principal Investigator
      KAKUDO K.
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Tokai Univ, School of Medicine
  •  Salmonella typhimurium Infection and Host Resistance - With Special Reference to Nonspecific Defense Mechanisms

    • Principal Investigator
      OZAWA Atsushi
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      細菌学
    • Research Institution
      Tokai University, School of Medicine
  •  制癌剤の生体内局在の研究(効果増強と耐性の克服)

    • Principal Investigator
      NAKASAKI Hisao
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Tokai University
  •  粥状硬化の発生,進展における中膜平滑筋細胞の脂質過酸化とその調節機構の意義Principal Investigator

    • Principal Investigator
      渡辺 慶一
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Tokai University
  •  Ecological regulation mechanism of cytotoxin activity produced by Clostridium difficile

    • Principal Investigator
      ATSUSHI OZAWA
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      細菌学
    • Research Institution
      Tokai University, School of Medicine
  •  Cytosolic Proteinの膜通過調節機構に関する研究Principal Investigator

    • Principal Investigator
      渡辺 慶一
    • Project Period (FY)
      1985
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Tokai University
  •  Pathogenetic Significance of Lipid Peroxidation in Various Cell Injuries, with a Special Reference to the Investigation on Cell Biological Characteristics of Glutathione Peroxidase-an Anti-lipoperoxidative Agent.Principal Investigator

    • Principal Investigator
      WATANABE Keiichi
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokai University
  • 1.  TAKEKOSHI Susumu (70216878)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 2.  YAMAMOTO Yorihiro (60134475)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  MORIUCHI Tetsuya (20174394)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  NAKASAKI Hisao (10056145)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  OZAWA Atsushi (50055638)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  OHNISHI Nobuhiko (30051717)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  TSUTSUMI Yutaka (80138643)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  OSAMURA Yoshiyuki (10100992)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  MITOMI Toshio (20055809)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  吉村 慎一 (30230808)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  下里 幸雄 (10076979)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  関口 清俊 (50187845)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  浜田 新七 (00172974)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  桜井 雅温 (20025604)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  横田 淳 (10191503)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  松島 一士 (70209542)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  瀧沢 俊也 (70197234)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  SATO Shinkichi (80119677)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  WAKAKI Moriaki (20100993)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  YOKOYAMA Seihichi (50096278)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  MATSUZAKI shouhei (40110902)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  TOKUDA Yutaka (20163975)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  KAKUDO K. (00112037)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  渋谷 誠 (50201546)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  森 一郎 (10157852)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  NABER Stephan p.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  WOLFE Hubert j.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  NARISAWA Sonoko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  MILLAN Jose Luis
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  STEPHAN P.Na
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  HUBERT J.Wol
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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