HARA Akira 原明

Researcher Number	00094334
Other IDs
Affiliation (based on the past Project Information) *help	2010 – 2012: 岐阜薬科大学, 薬学部, 教授 1996 – 2002: 岐阜薬科大学, 薬学部, 教授 1988 – 1991: 岐阜薬科大学, 薬学部, 助教授
Review Section/Research Field	Principal Investigator Biological pharmacy / 医薬分子機能学 / Drug development chemistry Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator ヒドロキシステロイド脱水素酵素 / structure-function relationship / 構造機能相関 / ジヒドロジオール脱水素酵素 / 非ステロイド性抗炎症薬 / 結晶化 / anti-inflammatory drug / genetic polymorphism / dihydrodiol dehydrogenase / 活性化剤 … More / cDNA / 阻害剤 / 遺伝的多型性 / 高次構造 / drug metabolism / L-gulonate dehydrogenase / xylitol dehydrogenase / uranate cycle / crystal structure / L-xylulose reductase / イサチン / ジアセチル還元酵素 / SDRファミリー / 薬物代謝 / グロン酸脱水素酵素 / キシリトール脱水素酵素 / ウロン酸回路 / 結晶構造 / キシルロース還元酵素 / gene structure / site-directed mutagenesis / new protein family / D-xylose dehydrogenase / 新規蛋白質ファミリー / 遺伝子構造 / 部位特異的変異 / 新規タンパク質ファミリー / D-キシロース脱水素酵素 / gene transfection / gene-expression regulation / activator / inhibitor / neurosteroids / hydroxysteroid dehydrogenase / ベンゾジアゼピン薬物 / ヒドロキシステロイド脱水祖酵素 / 前立腺疾患 / 神経疾患 / ベンズブロマロン / 遺伝子導入細胞 / 遺伝子導入 / 遺伝子発現調節 / 神経ステロイド / steroid metabolism / anti-hyperlipidemic drug / prostaglandin D_2 / aldo-keto reductase family / 高脂血症薬 / 家系調査 / 肝疾患 / ステロイド代謝 / 甲状腺ホルモン / 抗炎症薬 / プロスタグランジンD_2 / 遺伝子多型性 / アルド-ケト還元酵素ファミリー / allosteric effector / fatty acid / cooperativity / lipid metabolism / coenzyme binding / lung / carbonyl reductase / 酵素構造 / 化学修飾 / アルデヒド酸化 / 免疫組織化学 / 肺障害 / 活性調節 / アロステリック酵素 / アミノ酸配列 / アロステリック調節因子 / 脂肪酸 / 協同性 / 脂質代謝 / 補酵素結合 / 肺 / カルボニル還元酵素 / 医薬品設計 / アルドース還元酵素 / 抗癌剤耐性 / 制癌剤 / アルドーケト還元酵素 / 医薬品化学・医薬分子設計 / 肝機能診断薬 / 構造・機能相関 / アルド-ケト還元酵素 / 薬物ケトン還元酵素 … More Except Principal Investigator enzyme multiplicity / primates / indanol dehydrogenase / alcohol dehydrogenase / aldehyde reductase / hydroxysteroid dehydrogenase / carcinogenic aromatic hydrocarbon / dihydrodiol dehydrogenase / 組織化学 / 臓器分布 / 酵素多形 / インダノール脱水素酵素 / ジヒドロジオール脱水素酵素 / 多様性 / 酵素多様性 / 霊長類 / インダノ-ル脱水素酵素 / アルコ-ル脱水素酵素 / アルデヒド還元酵素 / ヒドロキシステロイド脱水素酵素 / 発癌性芳香族炭化水素 / ジヒドロジオ-ル脱水素酵素 Less

DEVELOPMENT OF ANTITUMOR DRUGS TARGETING TUMOR MARKERALDO-KETO REDUCTASESPrincipal Investigator
- Principal Investigator
  
  HARA Akira
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu Pharmaceutical University
Study on the uronate-cycle oxidoreductases that are expressed highly in kidneyPrincipal Investigator
- Principal Investigator
  
  HARA Akira
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu Pharmaceutical University
Development of drugs targeting neurosteroid-metabolizing enzymesPrincipal Investigator
- Principal Investigator
  
  HARA Akira
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Gifu Pharmaceutical University
Study of tissue-specific dihydrodiol dehydrogenasePrincipal Investigator
- Principal Investigator
  
  HARA Akira
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu Pharmaceutical University
Structures and clinical significance of polymorphism of human dihydrodiol dehydrogenasePrincipal Investigator
- Principal Investigator
  
  HARA Akira
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu Pharmaceutical University
ヒトの3α-ヒドロキシステロイド脱水素酵素の多様性と機能Principal Investigator
- Principal Investigator
  
  原明
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu Pharmaceutical University
Structure, Function and Regulation of Lung-Specific Carbonyl ReductasePrincipal Investigator
- Principal Investigator
  
  HARA Akira
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu Pharmaceutical University
Multiplicity and physiological role of primatial dihydrodiol dehydrogenase involved in the detoxification of carcinogenic aromatic hydrocarbons
- Principal Investigator
  
  SAWADA Hideo
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu Pharmaceutical University

All 2013 2012 2011 2010

All Journal Article Book

[Book] Springer, Aldo-keto reductases as new therapeutic targets for colon cancer chemoresistance2013
- Author(s)
  Matsunaga T, El-Kabbani O, Hara A
- Publisher
  Molecular Mechanisms of Tumor Cell Chemotherapy
- Data Source
  KAKENHI-PROJECT-22590102
[Book] Advances in molecular mechanisms and pharmacology of diabetic complications2010
- Author(s)
  V.Carbone, A.Hara, O.El-Kabbani
- Total Pages
  15
- Publisher
  Research Signpost
- Data Source
  KAKENHI-PROJECT-22590102
[Book] Aldehyde reductase structures complexed with aldose reductase inhibitors: Implications for inhibitor selectivity2010
- Author(s)
  Carbone V, Hara A, El-Kabbani O.RESEARCH SIGNPOST Publisher
- Publisher
  Advances in Molecular Mechanisms and Pharmacology of Diabetic Complications
- Data Source
  KAKENHI-PROJECT-22590102
[Journal Article] Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers2012
- Author(s)
  Matsunaga T, Hojo A, Yamane Y, Endo S, El-Kabbani O, Hara A
- Journal Title
  
  Chem. Biol. Interact
  
  Volume: 202 Issue: 1-3 Pages: 234-242
- DOI
  10.1016/j.cbi.2012.09.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590102, KAKENHI-PROJECT-22790074
[Journal Article] Aldo-keto reductase 1B10 and its role in proliferation capacity of drug-resistant cancers2012
- Author(s)
  Matsunaga T, Wada Y, Endo S, Soda M, El-Kabbani O, Hara A
- Journal Title
  
  Front. Pharmacol
  
  Volume: 3 Pages: 5-11
- DOI
  10.3389/fphar.2012.00005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590102, KAKENHI-PROJECT-22790074
[Journal Article] Probing the Inhi bitor Selectivity Pocket of Human 20α-Hydroxysteroid Dehydrogenase(AKR1 C1) with X-Ray Crystallography and Si te-Directed Mutagenesis2011
- Author(s)
  Ossama El-Kabbani, Urmi Dhagat, Midor i Soda, Satoshi Endo, Toshiyuki Matsu naga and Akira Hara
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 21 Issue: 8 Pages: 2564-2567
- DOI
  10.1016/j.bmcl.2011.01.076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790245, KAKENHI-PROJECT-22590102
[Journal Article] Inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1)2011
- Author(s)
  El-Kabbani O, Dhagat U, Hara A
- Journal Title
  
  J. Steroid Biochem. Mol. Biol
  
  Volume: 125 Issue: 1-2 Pages: 105-111
- DOI
  10.1016/j.jsbmb.2010.10.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590102
[Journal Article] Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)α-hydroxysteroid dehydrogenase (AKR1C21)2010
- Author(s)
  U.Dhagat, S.Endo, H.Mamiya, A.Hara, O.El-Kabbani
- Journal Title
  
  Acta Crystallogr.D Biol.Crystallogr.
  
  Volume: 66 Pages: 198-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590102
[Journal Article] Factorizing the role of a critical leucine residue in the binding of substrate to human 20α-hydroxysteroid dehydrogenase (AKR1C1).2010
- Author(s)
  U.Dhagat, S.Endo, M.Soda, A.Hara, O.El-Kabbani
- Journal Title
  
  Bioorg.Med.Chem.Lett.
  
  Volume: 20 Pages: 5274-5276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590102

1. NAKAGAWA Makoto (30188908)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. ENDO Satoshi (60433207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. USAMI Noriyuki (60257483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. DEYASHIKI Yoshihiro (00202193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SAWADA Hideo (90075945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TOYOOKA Naoki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KATO Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUNAGA Toshiyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. ISHIKURA Syuhei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. EL-KABBANI Ossama

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results

HARA Akira 原 明

Research Projects

Research Products

Co-Researchers

DEVELOPMENT OF ANTITUMOR DRUGS TARGETING TUMOR MARKERALDO-KETO REDUCTASESPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the uronate-cycle oxidoreductases that are expressed highly in kidneyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of drugs targeting neurosteroid-metabolizing enzymesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of tissue-specific dihydrodiol dehydrogenasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structures and clinical significance of polymorphism of human dihydrodiol dehydrogenasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒトの3α-ヒドロキシステロイド脱水素酵素の多様性と機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structure, Function and Regulation of Lung-Specific Carbonyl ReductasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Multiplicity and physiological role of primatial dihydrodiol dehydrogenase involved in the detoxification of carcinogenic aromatic hydrocarbons

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Springer, Aldo-keto reductases as new therapeutic targets for colon cancer chemoresistance2013

Author(s)

Publisher

Data Source

[Book] Advances in molecular mechanisms and pharmacology of diabetic complications2010

Author(s)

Total Pages

Publisher

Data Source

[Book] Aldehyde reductase structures complexed with aldose reductase inhibitors: Implications for inhibitor selectivity2010

Author(s)

Publisher

Data Source

[Journal Article] Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aldo-keto reductase 1B10 and its role in proliferation capacity of drug-resistant cancers2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Probing the Inhi bitor Selectivity Pocket of Human 20α-Hydroxysteroid Dehydrogenase(AKR1 C1) with X-Ray Crystallography and Si te-Directed Mutagenesis2011

Author(s)

Journal Title

DOI

Data Source

HARA Akira 原明