NUKAYA Haruo 糠谷東雄

… Alternative Names

Researcher Number	00094342
Other IDs
Affiliation (Current) *help	2018 : 静岡県立大学, 食品栄養科学部, 研究員
Affiliation (based on the past Project Information) *help	2014 : 静岡県立大学, 食品栄養科学部, 研究員 2010 – 2014 : 静岡県立大学, 食品栄養科学部, 客員教授 2009 : 静岡県立大学, 食品栄養科学部, 客員共同研究員
Review Section/Research Field	Except Principal Investigator Eating habits, studies on eating habits
Keywords	Except Principal Investigator 生活習慣病 / コレステロール / 分析科学 / 脂質 / 炎症 / オゾン酸化 / 好中球 / ミエロペルオキシダーゼ / 栄養学 / アルデヒド / 健康と食生活 / オゾン酸化コレステロール

Ozone-oxidized cholesterols as biomarkers for metabolic syndrome and life-style related diseases
- Principal Investigator
  
  OHSHIMA Hiroshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  University of Shizuoka
Elucidations of the mechanisms for the formation of cholesterol-ozonolysis products in inflamed tissues, their biological activities and involvement in disease development
- Principal Investigator
  
  OHSHIMA Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  University of Shizuoka

All 2015 2014 2013 2012 2011 2010 2009

All Journal Article Presentation Book

[Book] Inflammation Induced Carcinogenesis and Chemoprevention. Chemoprevention of Cancer and DNA Damage by Dietary Factors2009
- Author(s)
  Ohshima H., Miyoshi N., et al.
- Publisher
  WILEY-BLACKWELL
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Comprehensive analysis of the lipophilic reactive carbonyls present in biological specimens by LC/ESI-MS/MS2015
- Author(s)
  Tomono S, Miyoshi N, Ohshima H
- Journal Title
  
  J Chromatogrphy B
  
  Volume : 988 Pages : 149-156
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24300257
[Journal Article] Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis.2014
- Author(s)
  Hiramoto K, Satoh H, Suzuki T, Moriguchi T, Pi J, Shimosegawa T, and Yamamoto M.
- Journal Title
  
  Cancer Prev Res (Phila).
  
  Volume : 7 Pages : 835-844
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24680092, KAKENHI-PROJECT-25860547, KAKENHI-PUBLICLY-23112502, KAKENHI-PROJECT-21300280
[Journal Article] Implications of cholesterol autoxidation products in the pathogenesis of inflammatory diseases.2014
- Author(s)
  Miyoshi N, Iuliano L, Tomono S, Ohshima H.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : 446 Pages : 702-708
- DOI
  10.1016/j.bbrc.2013.12.107
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24300257, KAKENHI-PROJECT-24680075, KAKENHI-PROJECT-24700838, KAKENHI-PROJECT-25560057
[Journal Article] Occurrence of cytotoxic 9-oxononanoyl secosterol aldehydes in human low-density lipoprotein.2013
- Author(s)
  Miyoshi N, Iwasaki N, Tomono S, Higashi T, Ohshima H.
- Journal Title
  
  Free Radic. Biol. Med.
  
  Volume : 60 Pages : 73-79
- DOI
  10.1016/j.freeradbiomed.2013.01.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300257, KAKENHI-PROJECT-24680075, KAKENHI-PROJECT-24700838, KAKENHI-PROJECT-25560057
[Journal Article] Cytotoxic effects of secosterols and its derivatives on several cultured cells.2013
- Author(s)
  Tomono S
- Journal Title
  
  Biosci. Biotechnol.Biochem.
  
  Volume : 77 Pages : 651-653
- DOI
  10.1271/bbb.120758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650486, KAKENHI-PROJECT-24300257, KAKENHI-PROJECT-24680075, KAKENHI-PROJECT-24700838
[Journal Article] Occurrence of cytotoxic 9-oxononanoyl secosterol aldehydes in human low-density lipoprotein.2013
- Author(s)
  Miyoshi N
- Journal Title
  
  Free Radic Biol Med
  
  Volume : In press Pages : 143-149
- DOI
  10.3164/jcbn.11-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650486, KAKENHI-PROJECT-24680075, KAKENHI-PROJECT-23790747, KAKENHI-PROJECT-24300257, KAKENHI-PROJECT-24700838
[Journal Article] QT Interval Dispersion and Cardiac Sympathovagal Balance Shift in Rats with Acute Ethanol Withdrawal2012
- Author(s)
  Mabuchi R, Kurita A, Miyoshi N, Yokoyama A, Furuta T, Goda T, Suwa Y, Kan T, Amagai T, Ohshima H
- Journal Title
  
  Alcohol Clin Exp Res
  
  Volume : (in press) Pages : 223-230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280, KAKENHI-PROJECT-22590635
[Journal Article] Dysregulation of dimethylargininedimethylaminohydrolase/asymmetricdi methylarginine pathway in rat type II diabetic nephropathy2012
- Author(s)
  Lai YL, Aoyama S, Ohata M, Otsuka N, Shiokawa H, Tomono S, Fujiwara Y, Kanazawa H, Miyoshi N, Ohshima H
- Journal Title
  
  J.Clin.Biochem.Nutr.
  
  Volume : (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde : Implications for vascular and neurodegenerative diseases.2012
- Author(s)
  Lai YL, Tomono S, Miyoshi N, Ohshima H
- Journal Title
  
  J.Clin.Biochem.Nutr.
  
  Volume : 50 Pages : 84-9
- DOI
  10.3164/jcbn.11-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280, KAKENHI-PROJECT-24300257
[Journal Article] Development and application of a method for identification of isothiocyanate-targeted molecules in colon cancer cells.2012
- Author(s)
  Miyoshi, N., Yonemochi, T., Tomono, S., Fukutomi, R., Nakamura, Y., Ohshima, H.
- Journal Title
  
  Anal Biochem
  
  Volume : 429(2) Pages : 124-131
- DOI
  10.1016/j.ab.2012.07.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580129, KAKENHI-PROJECT-23650486, KAKENHI-PROJECT-24300257, KAKENHI-PROJECT-24680075, KAKENHI-PROJECT-24700838
[Journal Article] Analysis of Nε-ethyllysine in human plasma proteins by gas chromatography-negative ion chemical ionization/mass spectrometry as a biomarker for exposure to acetaldehyde and alcohol.2012
- Author(s)
  Mabuchi R., et al.
- Journal Title
  
  Alcohol. Clin. Exp. Res.
  
  Volume : (印刷中) Pages : 1013-1020
- DOI
  10.1111/j.1530-0277.2011.01705.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21680052, KAKENHI-PROJECT-23650486, KAKENHI-PROJECT-24300257, KAKENHI-PROJECT-24680075, KAKENHI-PROJECT-22350070
[Journal Article] A highly sensitive LC-ESI-MS/MS method for the quantification of cholesterol ozonolysis products secosterol-A and secosterol-B after derivatization with 2-hydrazino-1-methylpyridine.2011
- Author(s)
  Tomono S, Miyoshi N, Ito M, Higashi T, Ohshima H
- Journal Title
  
  J.Chromatogr.B
  
  Volume : 879 Pages : 2802-2802
- DOI
  10.1016/j.jchromb.2011.08.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280, KAKENHI-PROJECT-21680052, KAKENHI-PROJECT-23650486
[Journal Article] Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway2011
- Author(s)
  Tomono S, Miyoshi N, Shiokawa H, Iwabuchi T, Aratani Y, Higashi T, Nukaya H, Ohshima H
- Journal Title
  
  J. Lipid Res.
  
  Volume : 52 Pages : 87-97
- DOI
  10.1194/jlr.m006775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] The enhancement of the oral bioavailability of Y-tocotorienol in mice by Y-cyclodextrin inclusion.2011
- Author(s)
  Miyoshi N, Wakao Y, Tomono S, Tatemichi M, Yano T, Ohshima H.
- Journal Title
  
  J Nutr.Biochem.
  
  Volume : (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Chemoprevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by freeze-dried yam sanyaku and its constituent diosgenin.2011
- Author(s)
  Miyoshi N, Nagasawa T, Mabuchi R, Yasui Y, Wakabayashi K, Tanaka T, Ohshima H.
- Journal Title
  
  Cancer Prev.Res.
  
  Volume : (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway.2011
- Author(s)
  Tomono S, Miyoshi N, Shiokawa H, Iwabuchi T, Aratani Y, Higashi T, Nukaya H, Ohshima H.
- Journal Title
  
  J.Lipid Res.
  
  Volume : 52 Pages : 87-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde : Implications for vascular and neurodegenerative diseases.2011
- Author(s)
  Lai Y-L, Tomono S, Miyoshi N, Ohshima H.
- Journal Title
  
  J.Clin.Biochem.Nutr.
  
  Volume : (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] The enhancement of the oral bioavailability of γ-tocotrienol in mice by γ-cyclodextrin inclusion2011
- Author(s)
  Miyoshi N, Wakao Y, Tomono S, Tatemichi M, Yano T, Ohshima H
- Journal Title
  
  J.Nutr.Biochem.
  
  Volume : 22 Pages : 1121-1126
- DOI
  10.1016/j.jnutbio.2010.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Ingested Nitrate and Nitrite : Beneficial to Human Health?2010
- Author(s)
  Ohshima H, Miyoshi N.
- Journal Title
  
  Genes Environm.
  
  Volume : 32 Pages : 43-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Inhibition of L-Arginine Metabolizing Enzymes by L-Arginine-derived Advanced Glycation End Products.2010
- Author(s)
  Lai Y-L, Aoyama S, Nagai R, Miyoshi N, Ohshima H.
- Journal Title
  
  J Clin Biochem Nutr.
  
  Volume : 46 Pages : 177-185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Inhibitation of L-Arginine Metabolizing Enzymes by L-Arginine-derived Advanced Glycation End Products2010
- Author(s)
  Lai Y-L, Aoyama S, Nagai R, Miyoshi N, Ohshima H.
- Journal Title
  
  J.Clin.Biochem.Nutr. 46
  
  Pages : 177-185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Formation of cholesterol ozonolysis products through an ozone-free mechanism mediated by the myeloperoxidase-H_2O_2-chloride system. Biochem2009
- Author(s)
  Tomono S, Miyoshi N, Sato K, Ohba Y, Ohshima H
- Journal Title
  
  Biophys. Res. Commun
  
  Volume : 383 Pages : 222-222
- DOI
  10.1016/j.bbrc.2009.03.155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Journal Article] Formation of cholesterol ozonolysis products through an ozone-free mechanism mediated by the myeloperoxidase-H_2O_2-chloride system2009
- Author(s)
  Tomono S, Miyoshi N, Sato K, Ohba Y, Ohshima H
- Journal Title
  
  Biochem.Biophys.Res.Commun. 383
  
  Pages : 222-227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Denaturation of cellular proteins induced by secosterol aldehydes2014
- Author(s)
  Noriyuki Miyoshi, Susumu Tomono, Hiroshi Ohshima.
- Organizer
  SFRR-international 2014
- Place of Presentation
  Kyoto,Japan
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Global analysis of reactive carbonyls formed in neuronal PC-12 cells by exposed to amyloid-beta2014
- Author(s)
  Susumu Tomono, Misa Nagasawa, Noriyuki Miyoshi, Hiroshi Ohshima.
- Organizer
  SFRR-international 2014
- Place of Presentation
  Kyoto,Japan
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Identification of carcinogenic compounds formed by chronic ethanol feeding in feces of mice2013
- Author(s)
  Shoko Hirukawa, Shunsuke Sanada, Noriyuki Miyoshi, Hiroshi Ohshima.
- Organizer
  静岡健康・長寿学術フォーラム
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Acetaldehyde-modification of dehydrogenase/reductase member 2 decrease its binding to Mdm22013
- Author(s)
  Yuji Yamada, Aya Kurita, Susumu Tomono, Noriyuki Miyoshi, Hiroshi Ohshima.
- Organizer
  静岡健康・長寿学術フォーラム
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Conprehensive analytical method for lipophilic reactive carbonyl compounds in biological samples2013
- Author(s)
  Susumu Tomono, Noriyuki Miyoshi, Hiroshi Ohshima.
- Organizer
  SFRR-Europe 2013 Conference
- Place of Presentation
  Athens, Greece
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Cholesterol aldehydes: The mechanisms of their formation and pahological roles in oxidative stress related-disorders2013
- Author(s)
  Noriyuki Miyoshi, Susumu Tomono, Hiroshi Ohshima.
- Organizer
  3rd European Network for Oxysterol Research
- Place of Presentation
  Swansea, UK
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Search as novel diagnostic biomarkers for fecal small molecules responsible for metabolic syndrome in ob/ob mice2013
- Author(s)
  Shunsuke Sanada, Shoko Hirukawa, Noriyuki Miyoshi, Hiroshi Ohshima.
- Organizer
  静岡健康・長寿学術フォーラム
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] 日本のヤマイモ類及びその植物ステロイド成分によるマウス大腸発がんの予防2012
- Author(s)
  Hiroshi Ohshima, Tomoki Nagasawa, Natsuko Asai, Noriyuki Miyoshi, Keiji Wakabayashi, Takuji Tanaka
- Organizer
  The 1st International Conference on Pharma-Food
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] 飲酒およびアセトアルデヒド曝露のバイオマーカーとしてのタンパク質中Nε-エチルリジンの有用性2012
- Author(s)
  Ryota Mabuchi, Noriyuki Miyoshi, Akira Yokoyama, Yoshihide Suwa, Kiyonari Kuriki, Toshinao Goda, Takashi Amagai, Hiroshi Ohshima
- Organizer
  日本環境変異原学会第41回大会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-24300257
[Presentation] Chemopreventive effects of freeze-dried yams and its constituent dios genin on mouse colon carcinogenesis2011
- Author(s)
  Miyoshi N, Nagasawa T, Tanaka T, Wakabayashi K, Noguchi H, Ohshima H
- Organizer
  4th International Conference of Health and Longevity Sciences
- Place of Presentation
  静岡
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Anti-obesity effects of Chinese yam sanyaku and its constituent diosgenin in type II diabetic KK-A^y mice fed a high-fat diet2011
- Author(s)
  Asai N, Ohata M, Miyoshi N, Kanazawa H, Ohshima H
- Organizer
  2011 International conference on Food Factors
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Identification of target proteins responsible for chemopreventive activities of isothiocyanates in human colon cancer HCT116 cells2011
- Author(s)
  Yonemochi T, Nakamura Y, Ohshima H, Miyoshi N
- Organizer
  2011 International conference on Food Factors
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Development of a comprehensive analytical method for identification of isothiocyanates-binding proteins2011
- Author(s)
  Miyoshi N, Yonemochi T, Nakamura Y, Ohshima H
- Organizer
  2011 International conference on Food Factors
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] アセトアルデヒドを消去する食品及び食品成分の探索2010
- Author(s)
  鈴木啓子、三好規之、糠谷東雄、大島寛史
- Organizer
  第54回日本食品科学工学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] 乳がんのリスクマーカーとしての尿中のカテコールエストロゲン-DNA付加体の分析2010
- Author(s)
  戸井口恭子、三好規之、東達也、糠谷東雄、高橋智、若林敬二、大島寛史
- Organizer
  第39回日本環境変異原学会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Alteration in activity and expression of renal NOS and dimethylarginine dimethylaminohydrolase in type 2 diabetic rats2010
- Author(s)
  Ohata M, Lai Y-L, Aoyama S, Miyoshi N, Fujiwara A, Kanazawa H, Ohshima H.
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Secosterol-A, an oxidized cholesterol metabolite, may contribute to atherosclerosis and neurodegenerative diseases through inhibition of eNOS and nNOS2010
- Author(s)
  Lai Y-L, Tomono S, Miyoshi N, Ohshima H.
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Secosterol-A, an oxidized cholesterol metabolite, may contribute toatherosclerosis and neurodegenerative diseases through inhibition of eNOS and nNOS2010
- Author(s)
  Ying-Ling Lai, Susumu Tomono, Noriyuki Miyoshi, Hiroshi Ohshima
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Alterations of activities of enzymes involving in the regulation of nitricoxide biosynthesis in the kidney of OLETF rats, a model for type 2 diabetes mellitus2009
- Author(s)
  Lai Y-L, Aoyama S, Otsuka N, Shiokawa H, Miyoshi N, Ohshima H
- Organizer
  SFRR-Europ Meeting 2009
- Place of Presentation
  Rome, Italy
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] Qunatitative analysis of N^ε-ehyllysine in human plasma proteins by NCI-GC/MS as a biomarker for acetaldehyde exposure2009
- Author(s)
  Mabuchi R, Kurita A, Miyoshi N, Kan T, Amagai T, Ohshima H
- Organizer
  10th International Conference on Environmental Mutagens(ICEM)
- Place of Presentation
  Firenze, Italy
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] The myeloperoxidase-H_2O_2-chloride system produces cholesterol ozonolysis products via an ozone-free mechanism2009
- Author(s)
  Tomono S, Miyoshi N, Shiokawa H, Ito M, Aratani Y, Ohshima H
- Organizer
  SFRR-Europ Meeting 2009
- Place of Presentation
  Rome, Italy
- Data Source
  KAKENHI-PROJECT-21300280
[Presentation] The myeloperoxidase-H_2O_2-chloride system produces cholesterol ozonolysis products via an ozone free mechanism2009
- Author(s)
  Susumu Tomono, Noriyuki, Miyoshi, Hidemi, Shiokawa, Megumi, Ito, Yasuaki, Aratani, Hiroshi, Ohshima
- Organizer
  SFRR Europe meeting Rome 2009
- Place of Presentation
  Roma, Italy
- Data Source
  KAKENHI-PROJECT-21300280

1. OHSHIMA Hiroshi (80433209)

# of Collaborated Projects : 2results

# of Collaborated Products : 46results
2. MIYOSHI Noriyuki (70438191)

# of Collaborated Projects : 2results

# of Collaborated Products : 44results
3. GODA Toshinao (70195923)

# of Collaborated Projects : 2results

# of Collaborated Products : 3results
4. HIGASHI Tatsuya (90272963)

# of Collaborated Projects : 1results

# of Collaborated Products : 5results
5. TOMONO Susumu (60554011)

# of Collaborated Projects : 1results

# of Collaborated Products : 12results
6. SUZUKI Norio

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
7. MORIGUCHI Takashi

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
8. YAMAMOTO Eiichiro

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
9. 藤宮龍也

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
10. 劉金耀

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
11. 藤原章雄

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
12. 山本雅之

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
13. 丸山玲緒

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
14. 中村宜督

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
15. 雨谷敬史

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

NUKAYA Haruo 糠谷 東雄

MIYOSHI Noriyuki 糠谷 春雄

糠谷 東男 ヌカヤ ハルオ

Research Projects

Research Products

Co-Researchers

Ozone-oxidized cholesterols as biomarkers for metabolic syndrome and life-style related diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidations of the mechanisms for the formation of cholesterol-ozonolysis products in inflamed tissues, their biological activities and involvement in disease development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Inflammation Induced Carcinogenesis and Chemoprevention. Chemoprevention of Cancer and DNA Damage by Dietary Factors2009

Author(s)

Publisher

Data Source

[Journal Article] Comprehensive analysis of the lipophilic reactive carbonyls present in biological specimens by LC/ESI-MS/MS2015

Author(s)

Journal Title

Data Source

[Journal Article] Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis.2014

Author(s)

Journal Title

Data Source

[Journal Article] Implications of cholesterol autoxidation products in the pathogenesis of inflammatory diseases.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Occurrence of cytotoxic 9-oxononanoyl secosterol aldehydes in human low-density lipoprotein.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytotoxic effects of secosterols and its derivatives on several cultured cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Occurrence of cytotoxic 9-oxononanoyl secosterol aldehydes in human low-density lipoprotein.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] QT Interval Dispersion and Cardiac Sympathovagal Balance Shift in Rats with Acute Ethanol Withdrawal2012

Author(s)

Journal Title

Data Source

[Journal Article] Dysregulation of dimethylargininedimethylaminohydrolase/asymmetricdi methylarginine pathway in rat type II diabetic nephropathy2012

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde : Implications for vascular and neurodegenerative diseases.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development and application of a method for identification of isothiocyanate-targeted molecules in colon cancer cells.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of Nε-ethyllysine in human plasma proteins by gas chromatography-negative ion chemical ionization/mass spectrometry as a biomarker for exposure to acetaldehyde and alcohol.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A highly sensitive LC-ESI-MS/MS method for the quantification of cholesterol ozonolysis products secosterol-A and secosterol-B after derivatization with 2-hydrazino-1-methylpyridine.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway2011

Author(s)

NUKAYA Haruo 糠谷東雄

MIYOSHI Noriyuki 糠谷春雄

糠谷東男ヌカヤハルオ