SUGIBAYASHI Kenji 杉林堅次

Researcher Number	00105834
Other IDs
Affiliation *help	2016 – 2018 : 城西大学, 薬学部, 教授 2003 – 2011 : 城西大学, 薬学部, 教授 1998 – 2001 : 城西大学, 薬学部, 教授 1997 : Josai University, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 1995 : 城西大学, 薬学部, 助教授 1987 – 1988 : 城西大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Physical pharmacy / 医薬分子機能学 / Physical pharmacy / Medical pharmacy Except Principal Investigator Physical pharmacy
Keywords	Principal Investigator MTT試験 / electroporation / iontophoresis / MTT assay / 三次元培養ヒト皮膚モデル / 皮膚刺激 / high throughput screening / ヘアレスマウス / 塩化セチルピリジニウム / blood vessel-embolism … More Except Principal Investigator iontophoresis / ジェットインジェクター / jet injector / skin permeation / イオントフォレ-シス / 吸収促進効果 / enhancing effect / 皮膚透過性 Less

Biopharmaceutical delivery using transdermal patches having MN and EP systemsPrincipal Investigator
- Principal Investigator
  
  SUGIBAYASHI Kenji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Josai University
Nanovehicle/nanoparticle delivery through skinPrincipal Investigator
- Principal Investigator
  
  SUGIBAYASHI Kenji
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Josai University
Research for establishment of evaluation method for the skin irritation using a Three-Dimensional Cultured Human Skin Model instead of in vivo results.Principal Investigator
- Principal Investigator
  
  SUGIBAYASHI Kenji
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Josai University
Utility of the three-dimensional cultured human skin model as a tool to evaluate rapid determination of skin permeation of drag and skin irritation.Principal Investigator
- Principal Investigator
  
  SUGIBAYASHI Kenji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Josai University
Study on alternation preparations for intravenous infusion systemPrincipal Investigator
- Principal Investigator
  
  SUGIBAYASHI Kenji
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Josai University
Transdermal Delivery of Peptide-like Drugs by Iontophoresis with Jet Injection
- Principal Investigator
  
  MARIMOTO Yasunori.Ph.D.
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Josai University
Study on oily drug carriers with blood-embolism potentialPrincipal Investigator
- Principal Investigator
  
  SUGIBAYASHI Kenji
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Josai University

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] A hollow microneedle carrier for enhancing skin penetration of large molecular compounds2011
- Author(s)
  Nanthida Wonglertnirant, Tanasait Ngawhirunpat, Praneet Opanasopit, Hiroaki Todo, K.Sugibayashi
- Journal Title
  
  Adv.Mater.Res.
  
  Volume : 194-196 Pages : 549-553
- DOI
  10.4028/www.scientific.net/amr.194-196.549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590045
[Journal Article] A hollow microneedle carrier for enhancing skin penetration of large molecular compounds2011
- Author(s)
  Nanthida W, Tanasait N, Praneet O, Todo H, Sugibayashi K
- Journal Title
  
  Adv Mater. Res.
- Data Source
  KAKENHI-PROJECT-21590045
[Journal Article] Transdermal drug delivery by in-skin electroporation using a microneedle array.2010
- Author(s)
  Yan K, Todo H, Sugibayashi K.
- Journal Title
  
  Int J Pharm.
  
  Volume : 397 Pages : 77-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590045
[Journal Article] Transdermal drug delivery by in-skin electroporation using a microneedle array2010
- Author(s)
  Yan K, Todo H, Sugibayashi K
- Journal Title
  
  Int J Pharm
  
  Volume : 397 Pages : 77-83
- Data Source
  KAKENHI-PROJECT-21590045
[Journal Article] 薬物の皮膚透過促進技術:エレクトロポレーション、マイクロニードル単独効果、そしてマイクロニードル電極アレイを用いたエレクトロポレーションの効果2009
- Author(s)
  杉林堅次
- Journal Title
  
  Progress in drug delivery system XVIII
  
  Pages : 5-9
- Data Source
  KAKENHI-PROJECT-21590045
[Journal Article] 薬物の皮膚透過促進技術:エレクトロポレーション、マイクロニードル単独効果、そしてマイクロニードル電極アレイを用いたエレクトロポレーションの効果2009
- Author(s)
  杉林堅次
- Journal Title
  
  Progress in drug delivery system
  
  Volume : XVIII Pages : 5-9
- Data Source
  KAKENHI-PROJECT-21590045
[Journal Article] 紫外線防御試験法の国際的動向と紫外線防御剤の開発の課題: 化粧品に用いられるナノ粒子の曝露と安全性問題のあり方2008
- Author(s)
  杉林堅次
- Journal Title
  
  Fragrance journal 10月号
  
  Pages : 38-41
- Data Source
  KAKENHI-PROJECT-18590036
[Journal Article] 皮膚を介した薬物デリバリー2008
- Author(s)
  杉林堅次、杉野雅浩
- Journal Title
  
  化学工業 5月号
  
  Pages : 72-78
- Data Source
  KAKENHI-PROJECT-18590036
[Journal Article] 紫外線防御試験法の国際的動向と紫外線防御剤の開発の課題 : 化粧品に用いられるナノ粒子の曝露と安全性問題のおり方2008
- Author(s)
  杉林堅次
- Journal Title
  
  FRAGRANCE JOURNAL 10月号
  
  Pages : 38-41
- Data Source
  KAKENHI-PROJECT-18590036
[Journal Article] Safety evaluation of titanium dioxide nanoparticles by their a bsorption and elimination profiles2008
- Author(s)
  Kenji Sugibayashi, Hiroaki Todo, Eriko Kimura
- Journal Title
  
  J. Toxicol. Sci. 33
  
  Pages : 293-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590036
[Journal Article] 有効性を発揮させるための剤形構築、皮膚浸透・経皮吸収に及ぼす剤形の影響2007
- Author(s)
  杉林堅次
- Journal Title
  
  日本香粧品学会誌 30
  
  Pages : 261-265
- Data Source
  KAKENHI-PROJECT-18590036
[Journal Article] Kinetic Analysis on the Skin Disposition of Cytotoxicity as an Index of Skin Irritation Produced by Cetylpyridinium Chloride : Comparison of In Vitro Data using a Three-Dimensional Cultured Human Skin Model with In Vivo Results in Hairless Mice.2006
- Author(s)
  Kano S, Sugibayashi K.
- Journal Title
  
  Pharmaceutical Research 23・2
  
  Pages : 329-335
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590137
[Journal Article] Kinetic Analysis on the Skin Disposition of Cytotoxicity as an Index of Skin Irritation Produced by Cetylpyridinium Chloride : Comparison of In Vitro Data using a Three-Dimensional Cultured Human Skin Model with In Vivo Results in Hairless Mice.2006
- Author(s)
  Kano S, Sugibayashi K.
- Journal Title
  
  Pharmaceutical Research 23(2)
  
  Pages : 329-335
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590137
[Journal Article] SAFETY EVALUATION OF TITANIUM DIOXIDE NANOPARTICLES BY THEIR ABSORPTION AND ELIMINATION PROFILES
- Author(s)
  Kenji SUGIBAYASHI, Hiroaki TODO and Eriko KIMURA
- Journal Title
  
  Journal of Toxicological Sciences
  
  Pages : 0-0
- Data Source
  KAKENHI-PROJECT-18590036
[Journal Article] SAFETY EVALUATION OF TITANIUM DIOXIDE NANOPARTICLES BY THEIR ABSORPTION AND ELIMINATION PROFILES
- Author(s)
  Kenji SUGIBAYASHI, Hiroaki TODO, Eriko KIMURA
- Journal Title
  
  Journal of Toxicological Sciences (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590036
[Presentation] マイクロニードル電極を用いたエレクトロポレーション適用によるナノ粒子の皮内到達の可能性2011
- Author(s)
  喜島小翔、Yan Keshu、藤堂浩明、杉林堅次
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21590045
[Presentation] マイクロニードル電極を用いたエレクトロポレーションによる高分子薬物の経皮送達2009
- Author(s)
  杉林堅次
- Organizer
  第25回日本DDS学会
- Data Source
  KAKENHI-PROJECT-21590045
[Presentation] マイクロニードル電極を用いたエレクトロポレーションによる高分子薬物の経皮送達2009
- Author(s)
  杉林堅次
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡コンベンションアーツセンター
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-21590045
[Presentation] 経皮吸収促進技術とその評価法2009
- Author(s)
  杉林堅次
- Organizer
  半固形製剤教育研修会
- Place of Presentation
  東京、コスモステクニカルセンター
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-21590045
[Presentation] 微粒子酸化チタンの体内分布と毒性評価2009
- Author(s)
  木村恵理子、藤堂浩明、杉林堅次
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18590036
[Presentation] 薬物の皮膚透過性促進技術:エレクトロポレーション、マイクロニードル単独効果、そしてマイクロニードル電極アレーを用いたエレクトロポレーションの効果2009
- Author(s)
  杉林堅次
- Organizer
  第18回DDSカンファランス
- Place of Presentation
  静岡コンベンションアーツセンター
- Data Source
  KAKENHI-PROJECT-21590045
[Presentation] マイクロニードル電極を用いたエレクトロポレーションによる高分子薬物の経皮送達2009
- Author(s)
  杉林堅次
- Organizer
  日本薬剤学会第24回
- Data Source
  KAKENHI-PROJECT-21590045
[Presentation] 経皮吸収促進技術とその評価法、半固形製剤2009
- Author(s)
  杉林堅次
- Organizer
  教育研修会
- Data Source
  KAKENHI-PROJECT-21590045
[Presentation] ナノ粒子の皮膚暴露・皮膚浸透の可能性を考える2008
- Author(s)
  杉林堅次
- Organizer
  第15回日本免疫毒性学会
- Place of Presentation
  船堀、東京
- Data Source
  KAKENHI-PROJECT-18590036
[Presentation] Transdermal and intradermal delivery of high-molecular compounds: cut-off size of chemical compounds by skin and cutaneous vascular membranes2008
- Author(s)
  Kenji Sugibayashi
- Organizer
  France Japan 8th Drug Delivery Symposium
- Place of Presentation
  Cannes, France
- Data Source
  KAKENHI-PROJECT-18590036
[Presentation] Transdermal and intradermal delivery of high-molecular compounds : cut-off size of chemical compounds by skin and cutaneous vascular membranes2008
- Author(s)
  杉林堅次
- Organizer
  France Japan 8^<th> Drug Delivery Symposium
- Place of Presentation
  Cannes, France
- Data Source
  KAKENHI-PROJECT-18590036
[Presentation] 水溶性高分子およびナノスフェアの皮膚浸透ルートおよび浸透性に関する研究2007
- Author(s)
  安野浩崇、藤堂浩明、杉林堅次
- Organizer
  第127年会日本薬学会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-18590036
[Presentation] Enhanced skin permeationからinjection-like deliveryへ2006
- Author(s)
  藤堂浩明、杉林堅次
- Organizer
  第22回日本DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18590036

1. TODO Hiroaki (10383184)

# of Collaborated Projects : 3results

# of Collaborated Products : 11results
2. ISHII Hiroshi (90383182)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
3. NATSUME Hideshi (40180533)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
4. HASEGAWA Tetsuya (50245148)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
5. KIMURA Masayuki

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
6. ISHIBASHI Takuya

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. MARIMOTO Yasunori.Ph.D. (90001057)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. NUMAJIRI Sachihiko.M.S. (40245147)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. TAKAYAMA Kozo (00130758)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. HATANAKA Tomomi (10198749)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. JUNI Kazuhiko (80111178)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. KIMURA Masayuki.Ph.D.

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

SUGIBAYASHI Kenji 杉林 堅次

Research Projects

Research Products

Co-Researchers

Biopharmaceutical delivery using transdermal patches having MN and EP systemsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Nanovehicle/nanoparticle delivery through skinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for establishment of evaluation method for the skin irritation using a Three-Dimensional Cultured Human Skin Model instead of in vivo results.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Utility of the three-dimensional cultured human skin model as a tool to evaluate rapid determination of skin permeation of drag and skin irritation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on alternation preparations for intravenous infusion systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transdermal Delivery of Peptide-like Drugs by Iontophoresis with Jet Injection

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on oily drug carriers with blood-embolism potentialPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A hollow microneedle carrier for enhancing skin penetration of large molecular compounds2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A hollow microneedle carrier for enhancing skin penetration of large molecular compounds2011

Author(s)

Journal Title

Data Source

[Journal Article] Transdermal drug delivery by in-skin electroporation using a microneedle array.2010

Author(s)

Journal Title

Data Source

[Journal Article] Transdermal drug delivery by in-skin electroporation using a microneedle array2010

Author(s)

Journal Title

Data Source

[Journal Article] 薬物の皮膚透過促進技術:エレクトロポレーション、マイクロニードル単独効果、そしてマイクロニードル電極アレイを用いたエレクトロポレーションの効果2009

Author(s)

Journal Title

Data Source

[Journal Article] 薬物の皮膚透過促進技術:エレクトロポレーション、マイクロニードル単独効果、そしてマイクロニードル電極アレイを用いたエレクトロポレーションの効果2009

Author(s)

Journal Title

Data Source

[Journal Article] 紫外線防御試験法の国際的動向と紫外線防御剤の開発の課題: 化粧品に用いられるナノ粒子の曝露と安全性問題のあり方2008

Author(s)

Journal Title

Data Source

[Journal Article] 皮膚を介した薬物デリバリー2008

Author(s)

Journal Title

Data Source

[Journal Article] 紫外線防御試験法の国際的動向と紫外線防御剤の開発の課題 : 化粧品に用いられるナノ粒子の曝露と安全性問題のおり方2008

SUGIBAYASHI Kenji 杉林堅次