HORIUCHI Noboru 堀内登

… Alternative Names

堀内登ホリウチノボル

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Researcher Number	00107294
Other IDs
Affiliation (based on the past Project Information) *help	2011: 奥羽大学, 歯学部, 教授 2009: 奥羽大学, 歯学部, 教授 2003 – 2007: 奥羽大学, 歯学部, 教授 1998 – 2000: 奥羽大学, 歯学部, 教授 1991 – 1995: 奥羽大学, 歯学部, 教授
Review Section/Research Field	Principal Investigator Functional basic dentistry / Functional basic dentistry Except Principal Investigator Applied health science / Conservative dentistry / Surgical dentistry / Functional basic dentistry
Keywords	Principal Investigator PTHrP / 骨吸収 / 癌 / カルシウム調節ホルモン / 遺伝子発現 / PTH_rP / 1,25(OH)_2D_3 / Statins / MC3T3-E1 cells / BMP-2 … More / prenylation / Mineralization / PTHrP阻害剤 / 腎 / 250HD_3ー24OHase / 歯周病 / 250HD_3-24水酸化酵素 / PTH / 口腔癌細胞株 / 口腔癌 / 癌診断 / 高カルシウム血症 / 細胞分化 / 腫瘍マーカー / 増殖因子 / Oral cancer / Tumor marker / Hypercalcemia / Vitamin D-24-hydroxylase / Gene expression / 1alpha, 25-dihydroxyvitamin D_3 / Parathyroid hormone receptor / 骨粗鬆症 / グルココルチコイド / 1α-水酸化酵素 / 24-水酸化酵素 / ビタミンD受容体 / 転写調節 / Osteoporosis / Glucocorticoid / 1a-hydroxylase / 24-hydroxylase / Vitamin D receptor / Transcriptional regulation / Vascular endotherial growth factor(VEGF) / PI3 kinase / Prenylation / statins / vascular endothelial growth factor (VEGF) / hypoxia responsive elements (HRE) / mineralization / Vascular endotherial growth factor (VEGF) / P13 kinase / 歯学 / 発生、分化 / 細胞、組織 / 再生医学 / 脂質 / 発生・分化 / 細胞・組織 / Dentistry / Differentiation / Cell and Tissue / Lipid / Osteoblast / Chondrocyte / Statin / Adipocyte … More Except Principal Investigator PTH / PTHrP receptor / osteoblast / transcriptional factor / promoter / PTHrP / gel mobility shift assay / oral cancer / siRNA / initiator / 臨床 / 歯学 / 薬学 / 免疫学 / MTAセメント / スタチン / 石灰化 / メバロン酸 / 骨芽細胞 / Rho / MTA / セメント芽細胞 / 再生 / 分化制御 / PI3K / Akt / PTHrP recetor / south western Less

口腔の状態から消化管・免疫系の疾患を探る
- Principal Investigator
  
  林茂寛
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied health science
- Research Institution
  Ohu University
Regenerative effects of statin and MTA on teeth and periodontal tissue.
- Principal Investigator
  
  MAEDA Toyonobu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  Ohu University
Elucidation of Regulatory Mechanisms of Osteoblastic and Chondrocytic Differentiation by StatinsPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Noboru
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Ohu University
Analysis of transcription enhancing factor for PTH receptor that controls bone metabolism
- Principal Investigator
  
  KAWANE Tetsuya
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Ohu University
Mechanism of osteoblast differantiation by statins via stimulation of VEGF gene transcriptionPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Noboru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Ohu University
Identification of transcription enhancing fator for PTH receptor and analysis it's mechanism at jaw bone resorption site by oral cancer
- Principal Investigator
  
  KAWANE Tesuya
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Ohu University
Disorder of vitamin D metabolism in steroid-induced osteoporosisPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Noboru
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Functional basic dentistry
- Research Institution
  Ohu University
口腔粘膜上皮細胞の分化とPTH_rP遺伝子の発現Principal Investigator
- Principal Investigator
  
  堀内登
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Ohu University
Parathyroid hormone-related protein mRNA expression and oral cancer progressionPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Noboru
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Ohu University
骨吸収促進因子(PTHrP)の細胞内情報伝達機構の解明Principal Investigator
- Principal Investigator
  
  堀内登
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Ohu University
癌細胞より分泌される骨吸収促進因子(PTHrP)の作用機構Principal Investigator
- Principal Investigator
  
  堀内登
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Ohu University

All 2010 2009 2007 2006 2005 2004 2003

All Journal Article Presentation

[Journal Article] Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1α, 25-dihydroxyvitamin D_3 synthesis in leptin-deficient ob/ob mice2010
- Author(s)
  Tsuji K, Maeda T, Kawane T, Matsunuam A, Horiuchi N
- Journal Title
  
  J Bone Mineral Research (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21650182
[Journal Article] Dexamethasone suppresses parathyroid hormone-related protein expression by human oral squemous carcinoma cells (HSC-3)2010
- Author(s)
  Abe M, Horiuchi N
- Journal Title
  
  J Oral Biosciences 52
  
  Pages: 51-59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21650182
[Journal Article] Leptin stimulates fibroblast growth factor23expression in bone and suppresses renal 1alpha, 25-dihydroxyvitamin D3 synthesis in leptin-deficient mice2010
- Author(s)
  Tsuji K, Maeda T, Kawane T, Matsunuma A, Horiuchi N
- Journal Title
  
  J Bone Miner Res
  
  Pages: 1711-1723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791862
[Journal Article] The proteasome inhibitors epoximicin and MG262 suppress urokinase-tyep plasminogen activator expression by human oral squemous carcinoma cells (HSC-3)2009
- Author(s)
  Abe M, Horiuchi N
- Journal Title
  
  奥羽大学歯学誌 36
  
  Pages: 139-147
- Data Source
  KAKENHI-PROJECT-21650182
[Journal Article] Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation2009
- Author(s)
  Maeda T, Horiuchi N
- Journal Title
  
  J Biochem
  
  Pages: 771-781
- NAID
  10025187027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791862
[Journal Article] Simvastatin suppresses leptin expression in 3T3-Li adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.2009
- Author(s)
  Maeda T, Horiuchi N
- Journal Title
  
  J Biochemistry 145
  
  Pages: 771-781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21650182
[Journal Article] Up-regulation of PTH receptor mRNA expression by dexamethasone in UMR-106 osteoblast-like cells2007
- Author(s)
  Nobutaka, Haramoto, Tetssya, Kawane, Noboru, Horiuchi
- Journal Title
  
  Oral Diseases 13-1
  
  Pages: 23-31
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592045
[Journal Article] attenuates gene expression for renal 25-hydroxyvitamin D_3-1α-hydroxylase in mice via the long form of the leptin receptor2007
- Author(s)
  Ayako, Matsunuma, Noboru, Horiuchi, Leptin
- Journal Title
  
  Archives of Biochemistry and Biophysics 463-1
  
  Pages: 118-127
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592045
[Journal Article] Effect of leptin on regulation of renal 25-hydroxyvitamin D_3 metabolism and maintenance of calcium homeostasis2007
- Author(s)
  Ayako, Matsunuma, Noboru, Horiuchi
- Journal Title
  
  Journal of Oral Biosciences 49-2
  
  Pages: 97-104
- NAID
  10027102463
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592045
[Journal Article] Statins and bone metabolism2006
- Author(s)
  Noboru Horiuchi
- Journal Title
  
  Oral Diseases 12・2
  
  Pages: 85-101
- Data Source
  KAKENHI-PROJECT-18592045
[Journal Article] Statins and bone metabolism2006
- Author(s)
  Noboru, Horiuchi, Toyonobu, Maeda
- Journal Title
  
  Oral Diseases 12-2
  
  Pages: 85-101
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592045
[Journal Article] Identification of the promoter region of the parathyroid hormone receptor gene responsible for transcriptional suppression by insulin-like growth factor-I2005
- Author(s)
  Tetsuya, Kawane, Junnsei, Mimura, Yoshiaki, Fujii-Kuriyama, Noboru, Horiuchi
- Journal Title
  
  Archives of Biochemistry and Biophysics 439-1
  
  Pages: 61-69
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592045
[Journal Article] Identification of the promoter region of the parathyroid Hormone receptor gene responsible for transcriptional suppression by insulin-like growth factor-I.2005
- Author(s)
  Tetsuya Kawane, Junsei Mimura, Yoshiaki Fujii-Kuriyama, Noboru Horiuchi
- Journal Title
  
  Archives of Biochemistry and Biophysics in press
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591976
[Journal Article] Effect of leptin on renal 1 1α-hydroxylase expression in mice.2004
- Author(s)
  Noboru Horiuchi
- Journal Title
  
  Proceedings of 12th International Congress of Endocrinology
  
  Pages: 1153-1157
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15592130
[Journal Article] Atorvastatin enhances hone density in ovariectomized rats given 17j3-estradiol or human parathyroid hormone (1-34).2004
- Author(s)
  Tetsuya Kawane, Shinichi Terashima, Izuru Kurahashi, Toru Yanagawa, Hiroshi Yoshida, Noboru Horiuchi
- Journal Title
  
  Endocrine 24-2
  
  Pages: 121-129
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591976
[Journal Article] Suppression of parathyroid hormone-related protein expression by all trans-retinoic acid in human oral squamous carcinoma cells (HSC-3).2004
- Author(s)
  Masatoshi Abe, Nobutaka Haramoto, Hidefumi Itoh, Noboru Horiuchi.
- Journal Title
  
  Journal of Oral Biosciences 46-6
  
  Pages: 550-557
- NAID
  110003166657
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591976
[Journal Article] Induction of osteoblast differentiation indices by statins in MC3T3-E1 cells.2004
- Author(s)
  Toyonobu Maeda, Ayako Matsunuma, Izuru Kurahashi, Toru Yanagawa, Hiroshi Yoshida, Noboru Horiuchi
- Journal Title
  
  Journal of Cellular Biochemistry 92-3
  
  Pages: 458-471
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591976
[Journal Article] Effect of leptin on renal lα-chydroxylase expression in mice.2004
- Author(s)
  Noboru Horiuchi, Ayako Matsunuma, Toyonobu Maeda, Masatoshi Abe, Testuya Kawane
- Journal Title
  
  Proceedings of 12th International Congress of Endocrinology.
  
  Pages: 1153-1157
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591976
[Journal Article] Leptin corrects increased gene expression of renal 25-hydroxyvitamin D_3- lα-hydroxylase and -24-hydroxylase in leptin- deficient, ob/ob mice.2004
- Author(s)
  Ayako Matsunuma, Tetsuya Kawane, Toyonobu Maeda, Setsuo Hamada, Noboru Horiuchi
- Journal Title
  
  Endocrinology 145-3
  
  Pages: 1367-1375
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591976
[Journal Article] Effect of leptin on renal 1α-hydroxylase expression in mice.2004
- Author(s)
  Noboru Horiuchi
- Journal Title
  
  Proceedings of 12th International Congress of Endocrinology
  
  Pages: 1153-1157
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15592130
[Journal Article] Effect of leptin on renal 1α-hydroxylase expression in mice.2004
- Author(s)
  Noboru Horiuchi
- Journal Title
  
  Proceedings of 12th International Congress of Endocrinology.
  
  Pages: 1153-1157
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591976
[Journal Article] Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation.2003
- Author(s)
  Toyonobu Maeda, Tetsuya Kawane, Noboru Horiuchi
- Journal Title
  
  Endocrinology 144-2
  
  Pages: 681-692
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591976
[Journal Article] Parathyroid hormone (PTH) down-regulates PTH/PTH-related protein reeptor gene expression in UMR-106 osteoblast-like cells via a 3', 5'-cyclic adenosine monophosphate- dependent, protein kinase A-independent pathway.2003
- Author(s)
  Tetsuya Kawane, Junsei Mimura, Toru Yanagawa, Yoshiaki Fujii-Kuriyama, Noboru Horiuchi
- Journal Title
  
  Journal of Endocrinology 178
  
  Pages: 247-256
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591976
[Presentation] レプチンによる骨のFGF23合成を介した1α-水酸化酵素発現抑制2010
- Author(s)
  堀内登、辻潔美、前田豊点、松沼礼子, 川根徹也
- Organizer
  第31回東北骨代謝研究会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21650182
[Presentation] ST2細胞においてSimvastatinは骨分化を促進し脂肪分化を抑制する2010
- Author(s)
  前田豊信, 堀内登, 加藤靖正
- Organizer
  日本結合組織学会
- Data Source
  KAKENHI-PROJECT-21791862
[Presentation] レプチンによる骨のFGF23合成を介した1α-水酸化酵素発現抑制2010
- Author(s)
  堀内登, 前田豊信
- Organizer
  第31回東北骨代謝研究会
- Data Source
  KAKENHI-PROJECT-21791862
[Presentation] レプチンによる骨のFGF23合成を介した1α-水酸化酵素発現抑制2010
- Author(s)
  堀内登
- Organizer
  第31回東北骨代謝研究会
- Place of Presentation
  江陽グランドホテル(仙台市)
- Year and Date
  2010-02-06
- Data Source
  KAKENHI-PROJECT-21791862
[Presentation] スタチンによるレプチン合成抑制機構2009
- Author(s)
  前田豊信, 川根徹也, 阿部匡聡, 堀内登
- Organizer
  日本生化学会東北支部第75回例会
- Place of Presentation
  仙台
- Year and Date
  2009-05-09
- Data Source
  KAKENHI-PROJECT-21650182
[Presentation] スタチンによるレプチンの合成抑制機構2009
- Author(s)
  前田豊信, 堀内登
- Organizer
  日本生化学会東北支部第75回例会
- Data Source
  KAKENHI-PROJECT-21791862

1. KAWANE Tetsuya (00265208)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
2. AKENO Nagako (30231856)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. 西勝祥子 (30170484)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. ABE Masatoshi (10254872)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. MAEDA Toyonobu (10382756)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
6. MATSUNUMA Ayako (30296040)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
7. KATO Yasumasa (50214408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. KIMURA Yuichi (60211877)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OHNO Tomoya (50094941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YANAGAWA Tohru (10312852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KURAHASHI Izuni (40337259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 木村早苗 (10245011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 林茂寛 (50110565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 春日井昇平 (70161049)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 辻典子 (30343990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. OHKAWA Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HORIUCHI Noboru 堀内 登

堀内 登 ホリウチ ノボル

Research Projects

Research Products

Co-Researchers

口腔の状態から消化管・免疫系の疾患を探る

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regenerative effects of statin and MTA on teeth and periodontal tissue.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of Regulatory Mechanisms of Osteoblastic and Chondrocytic Differentiation by StatinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of transcription enhancing factor for PTH receptor that controls bone metabolism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of osteoblast differantiation by statins via stimulation of VEGF gene transcriptionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of transcription enhancing fator for PTH receptor and analysis it's mechanism at jaw bone resorption site by oral cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Disorder of vitamin D metabolism in steroid-induced osteoporosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

口腔粘膜上皮細胞の分化とPTH_rP遺伝子の発現Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Parathyroid hormone-related protein mRNA expression and oral cancer progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

骨吸収促進因子(PTHrP)の細胞内情報伝達機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

癌細胞より分泌される骨吸収促進因子(PTHrP)の作用機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1α, 25-dihydroxyvitamin D_3 synthesis in leptin-deficient ob/ob mice2010

Author(s)

Journal Title

Data Source

[Journal Article] Dexamethasone suppresses parathyroid hormone-related protein expression by human oral squemous carcinoma cells (HSC-3)2010

Author(s)

Journal Title

Data Source

[Journal Article] Leptin stimulates fibroblast growth factor23expression in bone and suppresses renal 1alpha, 25-dihydroxyvitamin D3 synthesis in leptin-deficient mice2010

HORIUCHI Noboru 堀内登

堀内登ホリウチノボル