OHATA Hisayuki 大幡久之

Researcher Number	00119166
Other IDs
Affiliation (Current)	2022: 昭和大学, 教養部, 客員教授
Affiliation (based on the past Project Information) *help	2009 – 2011: Showa University, 薬学部, 准教授 2001 – 2005: 昭和大学, 薬学部, 助教授 1998 – 1999: 昭和大学, 薬学部, 助教授 1989 – 1990: 昭和大学, 薬学部・薬理学教室, 助手
Review Section/Research Field	Principal Investigator General physiology / Biological pharmacy / 応用薬理学・医療系薬学 / General pharmacology Except Principal Investigator Biological pharmacy / General pharmacology / Functional basic dentistry / Psychiatric science
Keywords	Principal Investigator 機械受容応答 / 機械受容チャネル / リゾホスファチジン酸 / 細胞内Ca^<2+>イオン濃度 / mechanoreception / mechanosensitive channel / laser scanning confocal microscopy / lens epithelial cells / 血管内皮細胞 / 流れ刺激 … More / in situ / intracellular Ca^<2+> ion concentration / lysophosphatidic acid / 血管 / 内皮細胞 / 平滑筋細胞 / リゾリン脂質 / 収縮弛緩反応 / 腸間膜動脈 / シェアストレス / アセチルコリン / 細胞内カルシウムイオン濃度 / 水晶体上皮細胞 / 共焦点レーザー走査顕微鏡 / 高速四次元画像化法 / intracellular CaィイD12+ィエD1 ion concentration / lysophosphatide acid / lens epithelian cells / リゾホスファチジン … More Except Principal Investigator differential cloning / microarray / うつ病 / 抗うつ薬 / 開口放出 / 平滑筋 / ムスカリン受容体 / 単離筋細胞の収縮反応測定法 / 単離平滑筋細胞の調製法 / 平滑筋細胞の収縮様式 / 受容体のアゴニスト親和性 / 筋収縮でのホスファチジン酸の役割 / 細胞内カルシウム動態 / 単離細胞 / コラゲナ-ゼ / パパイン / Gpp(NH)p / ^3H-QNB / モルモット / 回腸縦走筋 / Smooth Muscle / Muscarinic Receptor / determination of contractile responses of single m / preparation of single muscle cells / mode of contractile responses of visceral smooth m / affinity of muscarinic receptors to agonists / role of phosphatidic acid in contraction of smooth / movement of intracellular calcium in smooth muscle / 03determination of contractile responses of single muscle cells / 05mode of contractile responses of visceral smooth muscle / 07role of phosphatidic acid in contraction of smooth muscle / 08movement of intracellular calcium in smooth muscle cells / ラット / 脳 / 神経可塑性 / Differential Display / 遺伝子 / 分子生物学 / rat / brain / depression / neuroplasticity / antidepressant / exocytosis / 三叉神経 / 運動ニューロン / スパイク後過分極電位 / パッチクランプ / スライス標本 / 開口筋 / 閉口筋 / 拮抗筋 / trigeminal / motoneuron / afterhyperpolarization / patch clamp / slice preparation / jaw-closing muscle / jaw-opening muscle / プレシナプス / 神経伝達物質 / 小胞 / タンパク / ANTIDEPRESSANT / PRESYNAPSE / NEUROTRANSMITTER / EXOCYTOSIS / SYNAPTIC VESICLE Less

Shear stress-dependent vasospasm induced by lysophosphatidic acidPrincipal Investigator
- Principal Investigator
  
  OHATA Hisayuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Showa University
Effect of lysophosphatidic acid in fluid flow-response in vascular endothelial cellsPrincipal Investigator
- Principal Investigator
  
  OHATA Hisayuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Showa University
THE EXPRESSION OF SYNAPTIC VESICLE PROTEINS AFTER CHRONIC ANTIDEPRESSANT TREATMENT IN RAT BRAIN.
- Principal Investigator
  
  YAMADA Mitsuhiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY
Defference in physiological and mophological properties between jaw-closing and opening motoneurons
- Principal Investigator
  
  INOUE Tomio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Showa University
THE INVESTIGATION OF THE THERAPEUTIC MECHANISMS OF ANTIDEPRESSANT ON NEUROTRANSMITTER RELEASE
- Principal Investigator
  
  MOMOSE Kazutaka
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Showa University
Role of lysophosphatidic acid in fluid flow-response in vascular endothelial cellsPrincipal Investigator
- Principal Investigator
  
  OHATA Hisayuki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Showa University
Research for functional molecule involved in mechanical stress^induced increase in CaィイD12+ィエD1 from basement membranePrincipal Investigator
- Principal Investigator
  
  OHATA Hisayuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Characterization of Muscarinic Receptors in Singl Smooth Muscle Cells
- Principal Investigator
  
  MOMOSE Kazutaka
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Department of Pharmacology, School of Pharmaceutical Sciences, Showa University

All 2011 2010 2006 2005 2004

All Journal Article

[Journal Article] Lysophosphatidic acid induces shear stress-dependent Ca2+ influx inmouse aortic endothelial cells in situ2011
- Author(s)
  H.Ohata, H.Yamada, K.Momose
- Journal Title
  
  Experimental Physiol
  
  Volume: 96 Pages: 468-475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590240
[Journal Article] Shear Stress-dependent Effects of Lysophosphatidic Acid on Agonist-induced Vasomotor Responses in Rat Mesenteric Artery2011
- Author(s)
  K. Shibata, T. Miyazaki, H. Ohata and K. Honda
- Journal Title
  
  J Cardiovascul Pharmacol
  
  Volume: 57 Pages: 604-610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590240
[Journal Article] Lysophosphatidic acid induces shear stress-dependent Ca^<2+> influx in mouse aortic endothelial cells in situ2011
- Author(s)
  H. Ohata, H. Yamada, K. Momose
- Journal Title
  
  Experimental Physiol
  
  Volume: 96 Pages: 468-475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590240
[Journal Article] Lysophosphatidic acid induces shear stress-dependent Ca2+ influx in mouse aortic endothelial cells in situ2011
- Author(s)
  Hisayuki Ohata, Hideyuki Yamada, Kazutaka Momose
- Journal Title
  
  Exp.Physiol.
  
  Volume: 96 Pages: 468-475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590240
[Journal Article] m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions2010
- Author(s)
  Miyazaki T, Honda K, Ohata H.
- Journal Title
  
  Cardiovasc Res 85
  
  Pages: 530-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590240
[Journal Article] Lysophosphatidic acid induces plasma exudation and histamine release in mice via LPA.2006
- Author(s)
  Terumasa Hashimoto, Hisayuki Ohata, Kazuo Honda.
- Journal Title
  
  J.Pharmacol.Sci. 100
  
  Pages: 72-76
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590206
[Journal Article] Expression of NDRG2-S and NDRG2-L after antidepressant and electroconvulsive treatment in rat frontal cortex2005
- Author(s)
  Takahashi, K., Yamada, M., Ohata, H., Higuchi, T., Yamada, M., Momose, K.
- Journal Title
  
  Int.Neuropsychopharmacol. 8
  
  Pages: 381-389
- Data Source
  KAKENHI-PROJECT-16591162
[Journal Article] Ndrg2 promotes neurite outgrowth of NGF-differentiated PC12 cells2005
- Author(s)
  Takahashi, K., Yamada, M., Ohata, H., Honda, K., Yamada, M.
- Journal Title
  
  Neurisci.Lett 388
  
  Pages: 157-162
- Data Source
  KAKENHI-PROJECT-16591162
[Journal Article] 流れ刺激存在下の血管内皮細胞において認められる細胞内カルシウム濃度上昇によるカルパインを介する細胞形態の制御2005
- Author(s)
  宮崎拓郎, 山本雅幸, 本田一男, 大幡久之
- Journal Title
  
  日本薬理学雑誌 126
  
  Pages: 256-261
- NAID
  10016912541
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590206
[Journal Article] Lysophosphatidic acid induces histamine release from mast cells and skin fragments.2005
- Author(s)
  Hashimoto, T., H.Ohata, K.Momose
- Journal Title
  
  Pharmacology 75
  
  Pages: 13-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590206
[Journal Article] Itch-scratch response induced by lysophosphatidic acid in mice2004
- Author(s)
  Hashimoto, Terumasa, H.Ohata, K.Momose.
- Journal Title
  
  Pharmacology 72
  
  Pages: 51-56
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590206
[Journal Article] メカノセンシタイザーとしてのリゾホスファチジン酸の役割2004
- Author(s)
  大幡久之, 他
- Journal Title
  
  日本薬理学雑誌 124
  
  Pages: 329-335
- NAID
  10014385056
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590206
[Journal Article] ナカノセンシタイザーとしてのリゾホスファチジン酸の役割2004
- Author(s)
  大幡久之, 新岡丈治, 金明淑, 安藤さなえ, 山本雅幸, 百瀬和享
- Journal Title
  
  日本薬理学雑誌 124
  
  Pages: 329-335
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590206

1. YAMAMOTO Masayuki (90307067)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. MOMOSE Kazutaka (80004597)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. YAMADA Mitsuhiko (60240040)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. FAN Yan-Il (50228855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. INOUE Tomio (70184760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KAMIJIMA Kunotoshi (80051613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山上芳雄 (10220237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OHATA Hisayuki 大幡 久之

Research Projects

Research Products

Co-Researchers

Shear stress-dependent vasospasm induced by lysophosphatidic acidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of lysophosphatidic acid in fluid flow-response in vascular endothelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE EXPRESSION OF SYNAPTIC VESICLE PROTEINS AFTER CHRONIC ANTIDEPRESSANT TREATMENT IN RAT BRAIN.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Defference in physiological and mophological properties between jaw-closing and opening motoneurons

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE INVESTIGATION OF THE THERAPEUTIC MECHANISMS OF ANTIDEPRESSANT ON NEUROTRANSMITTER RELEASE

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of lysophosphatidic acid in fluid flow-response in vascular endothelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for functional molecule involved in mechanical stress^induced increase in CaィイD12+ィエD1 from basement membranePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of Muscarinic Receptors in Singl Smooth Muscle Cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Lysophosphatidic acid induces shear stress-dependent Ca2+ influx inmouse aortic endothelial cells in situ2011

Author(s)

Journal Title

Data Source

[Journal Article] Shear Stress-dependent Effects of Lysophosphatidic Acid on Agonist-induced Vasomotor Responses in Rat Mesenteric Artery2011

Author(s)

Journal Title

Data Source

[Journal Article] Lysophosphatidic acid induces shear stress-dependent Ca^<2+> influx in mouse aortic endothelial cells in situ2011

Author(s)

Journal Title

Data Source

[Journal Article] Lysophosphatidic acid induces shear stress-dependent Ca2+ influx in mouse aortic endothelial cells in situ2011

Author(s)

Journal Title

Data Source

[Journal Article] m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions2010

Author(s)

Journal Title

Data Source

[Journal Article] Lysophosphatidic acid induces plasma exudation and histamine release in mice via LPA.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Expression of NDRG2-S and NDRG2-L after antidepressant and electroconvulsive treatment in rat frontal cortex2005

Author(s)

Journal Title

OHATA Hisayuki 大幡久之