ENDO Toyoshi 遠藤登代志

Researcher Number	00152017
Affiliation (based on the past Project Information) *help	2014: 山梨大学, 総合研究部, その他 2014: 山梨大学, 総合研究部, 医学研究員 2013: 山梨大学, 医学工学総合研究部, 医学研究員 2012: 山梨大学, 医学工学総合研究部, 准教授 2007 – 2011: University of Yamanashi, 大学院・医学工学総合研究部, 准教授 … More 2003 – 2004: 山梨大学, 大学院・医学工学総合研究部, 助教授 2002: University of Yamanashi, Faculty of Medicine, Assistant Professor, 医学部, 講師 2000 – 2001: 山梨医科大学, 医学部, 講師 1990 – 1998: 山梨医科大学, 医学部, 講師 1994: University of Yamanashi Medical School Less
Review Section/Research Field	Principal Investigator 内分泌・代謝学 / Metabolomics / Endocrinology Except Principal Investigator Endocrinology
Keywords	Principal Investigator 自己抗体 / TTF-1 / 甲状腺 / thyrotropin / 甲状腺癌 / アミラーゼ / 自己免疫性膵炎 / 劇症1型糖尿病 / ELISA / transgenic rat … More / 遺伝子発現 / 転写因子 / thyroid / サイロトロピンレセプター / thyroid cancer / 1型糖尿病 / cDNA / バセドウ病 / organogenesis / β cell / pancreas / pancreatic puodenal homeobox-1 / EYFP / homeobox-1 / pancreatic duodenal / 糖尿病 / トランスジェニックマウス / β細胞 / 膵臓 / pancreatic duct / beta cell / transgenic mouse / YFP / PDX-1 / T3 / thyroid stimulating antibody / B7.1 / MHC class II antigen / Graves' disease / hytマウス / hyt / 遺伝子欠損マウス / TSHレセプター抗体 / 眼球突出 / Transgenic rat / クラスII主要組織適合抗原 / class II transactivator / クラスII主要組織適合抗体 / thyroid transcription factor-1 / gene expression / iodide symporter / sodium / thyroid gland / ヨードトランスポーター / promoter / transcription / 組織特異性 / 転写開始点 / autoregulation / neoplasm / point mutation / thyrotropin receptor / 変異 / サイロトロピン・レセプター(TSH-R) / サイロトロピン(TSH) / 点変異 / サイロトロピン / GRP78 protein / Po protein / heat shock protein / ribosome / molecular biology / 甲状腺乳頭癌 / 腫瘍マ-カ- / 癌 / cDNAクロ-ニング / GRP78蛋白 / 熱ショック蛋白 / リボゾ-ム / 分子生物学 / DNA 免疫 / DNA免疫 / 慢性膵炎 / Amylaseα-2A / ２型糖尿病 / 劇症１型糖尿病 / IgG4 / 劇症1型糖尿 / 糖質代謝異常 / エネルギー / 合成ペプチド / TSHレセプター … More Except Principal Investigator Class II transactivator / クラスII主要組織適合抗原 / TSHレセプター抗体 / 眼球突出 / バセドウ病 Less

Pathopysiology of fuluminant type 1 diabetes and development of its new therapyPrincipal Investigator
- Principal Investigator
  
  ENDO Toyoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  University of Yamanashi
Characterization of autoantibody against Amylaseα-2A in patients with fulminant type 1 diabetes mellitus and autoimmune pancreatitis, and its clinical use.Principal Investigator
- Principal Investigator
  
  ENDO Toyoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  University of Yamanashi
Early detection and diagnosis of fulminant type 1 diadetes mellitusPrincipal Investigator
- Principal Investigator
  
  ENDO Toyoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  University of Yamanashi
Organogenesis of pancreas in PDX-1 promoter/YFP transgenic mousePrincipal Investigator
- Principal Investigator
  
  ENDO Toyoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  University of Yamanashi
クラスII主要組織適合抗原発現誘導細胞によるバセドウ症眼症発症モデル動物の作成
- Principal Investigator
  
  女屋敏正
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  山梨医科大学
Analysis of thyroid function in rats specifically expressing MHC class II and B7.1 in the thyroidPrincipal Investigator
- Principal Investigator
  
  ENDO Toyoshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  University of Yamanashi Faculty of Medicine
Strucure and function of rat sodium/iodide symporter gene and its expression mechanism in the thyroidPrincipal Investigator
- Principal Investigator
  
  ENDO Toyoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Yamanashi Medical University
Analysis of the thyroid transcription factor-1(TTF-1) gene expression in thyroid neoplastic tissues.Principal Investigator
- Principal Investigator
  
  ENDO Toyoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Yamanashi Medical University
Molecular analysis of thyrotropin receptor in thyroid noeplasmPrincipal Investigator
- Principal Investigator
  
  ENDO Toyoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  University of Yamanashi Medical School
分子生物学に基づくサイロトロピンレセプター自己抗体の解析及び産生機序の研究Principal Investigator
- Principal Investigator
  
  遠藤登代志
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  山梨医科大学
Molecular cloning of cDNAs corresponding to mRNAs whchi increase in malignantly transformer FRTL cells.Principal Investigator
- Principal Investigator
  
  ENDO Toyoshi
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Yamanashi Medical College

All 2014 2013 2012 2011 2010 2009 2008 2004 Other

All Journal Article Presentation

[Journal Article] Distinct cell clusters touching islet cells induce islet cell replication in association with over-expression of Regenerating Gene (REG) protein in fulminant type 1 diabetes.2014
- Author(s)
  Aida K, Saitoh S, Nishida Y, Yokota S, Ohno S, Mao X, Akiyama D, Tanaka S, Awata T, Shimada A, Oikawa Y, Shimura H, Furuya F, Takizawa S, Ichijo M, Ichijo S, Itakura J, Fujii H, Hashiguchi A, Takasawa S, Endo T, Kobayashi T.
- Journal Title
  
  PLoS One.
  
  Volume: 9(4)
- Data Source
  KAKENHI-PROJECT-24591320
[Journal Article] Excess TSH causes abnormal skeletal development in young mice with hypothyroidism via suppressive effects on the growth plate.2013
- Author(s)
  Endo T, Kobayashi T.
- Journal Title
  
  Am J Physiol Endocrinol Metab.
  
  Volume: 305(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591320
[Journal Article] Ligand-Bound Thyroid Hormone Receptor Contributes to Reprogramming of Pancreatic Acinar Cells Into Insulin-Producing Cells.2013
- Author(s)
  Furuya F, Shimura H, Asami K, Ichijo S, Takahashi K, Kaneshige M, Oikawa Y, Aida K, Endo T, Kobayashi T.
- Journal Title
  
  J Biol Chem.
  
  Volume: 288(22) Pages: 16155-16166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591320
[Journal Article] Concurrent overexpression of RET/PTC1 and TTF1 confers tumorigenicity to thyrocytes.2013
- Author(s)
  Endo T, Kobayashi T.
- Journal Title
  
  Endocr Relat Cancer
  
  Volume: 20(6) Pages: 767-776
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591320
[Journal Article] Immunization of mice with a newly identified thyroid-stimulating hormone receptor splice variant induces Graves'-like disease.2013
- Author(s)
  Endo T, Kobayashi T.
- Journal Title
  
  J Autoimmun.
  
  Volume: 43 Pages: 18-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591320
[Journal Article] Thyroid-specific gene expression in chondrocytes2011
- Author(s)
  Endo T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: Vol.416(3-4) Pages: 227-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591127
[Journal Article] Thyroid-specific gene expression inchondrocytes2011
- Author(s)
  Toyoshi Endo, Tetsuro Kobayashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 416 Pages: 227-231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591127
[Journal Article] RIG-I-and MDA5-Initiated Innate Immunity Linked With Adaptove Immunity Acceleratesβ-Cell Death in Fulminant Type 1Diabetes2011
- Author(s)
  Kaoru Aida, Yoriko Nishida, Shoichiro Tanaka, Taro Maruyama, Akira Shimada, Takuya Awata, Masako Suzuki, Hiroki Shimura, Soichi Takizawa, Masashi Ichijo, Daiichiro Akiyama, Fumihiko Furuya, Akio Kawaguchi, Masahiro Kaneshige, Jun Itakura, Hideki Fujii, Toyoshi Endo, and Tetsuro Kobayashi
- Journal Title
  
  Diabetes
  
  Volume: 60 Pages: 884-889
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591127
[Journal Article] Runx2 Deficiency in Mice Causes Decreased Thyroglobulin Expression and Hypothyroidism2010
- Author(s)
  Toyoshi Endo and Tetsuro Kobayashi
- Journal Title
  
  Molecular Endocrinology
  
  Volume: 24 Pages: 1267-1273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591127
[Journal Article] lase α-2A Autoantibod ies : Novel Marker of Autoimmune Pancre atitis and Fulminant Type 1 Diabetes Mell itus2009
- Author(s)
  Endo T, et.al
- Journal Title
  
  Diabetes 58
  
  Pages: 732-777
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591041
[Journal Article] Amylase alpha-2A autoantibodies : NovelMarker of Autoimmune Pancreatitis and Fulminant Type 1 Diabetes2009
- Author(s)
  Toyoshi Endo, Soichi Takizawa, Shoichiro Tanaka, Masashi Takahashi, Hideki Fujii, Terumi Kamisawa, and Tetsuro Kobayashi
- Journal Title
  
  Diabetes
  
  Volume: 58 Pages: 732-737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591127
[Journal Article] Amylase α-2A Autoantibodies : Novel Marker of Autoimmune Pancreatitis and Fulminant Type 1 Diabetes Mellitus.2009
- Author(s)
  Endo T, et al.
- Journal Title
  
  Diabetes 58
  
  Pages: 732-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591041
[Journal Article] Distinct diagnostic criteria of fulminant type I diadetes based on serum C-peptide response and HbA1c levels at onset.2004
- Author(s)
  Tanaka S, Endo T, Aida K et al.
- Journal Title
  
  Dibetes Care 27
  
  Pages: 1936-1941
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590934
[Journal Article] Distinct diagnostic criteria of fulminant type I diadetes based on serum C-peptide response and HbA1c levels at onset2004
- Author(s)
  Tanaka S, Endo T, Aida K et al.
- Journal Title
  
  Dibetes Care 27
  
  Pages: 1396-1941
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590934
[Journal Article] Distinct Diagnostic Criteria of Fuluminat Type I Diabetes Based on Serum C peptide Response and HbAic levels at Onset2004
- Author(s)
  Tanaka S, Endo T, Aida K et al.
- Journal Title
  
  Diadetes Care 27
  
  Pages: 1936-1936
- Data Source
  KAKENHI-PROJECT-15590934
[Journal Article] HSP 10 is a new autoantigen in both autoimmune pancreatitis and fulminant type 1 diabetes
- Author(s)
  S.Takizawa, T. Endo, Xing Wanjia, S. Tanaka, M. Takahashi, T. Kobayashi
- Journal Title
  
  Biochem Biophys Res Commun (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591041
[Presentation] 膵β細胞におけるIFNγ発現についての検討2012
- Author(s)
  一條　昌志, 志村　浩己, 滝澤　壮一, 古屋　文彦, 田中　昌一郎, 會田　薫, 遠藤　登代志, 小林　哲郎.
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-24591320
[Presentation] 劇症1型糖尿病における自己抗体認識抗原であるアミラーゼの膵島での発現調節機構および機能の解析2010
- Author(s)
  青柳美帆,志村浩己,滝澤壮一,高橋昌志,山下さやか,古屋文彦,田中昌一郎,遠藤登代志,小林哲郎
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-21591127
[Presentation] 自己免疫性膵炎と劇症1型糖尿病に検出される膵外分泌抗体の対応抗原2008
- Author(s)
  滝澤壮一、遠藤登代志、田中昌一郎、小林哲郎
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-23
- Data Source
  KAKENHI-PROJECT-19591041
[Presentation] Novel autoantibody against heat shock protein 10 in diabetes associated with autoimmune pancreatitis and fulminant type 1 diabetes2008
- Author(s)
  Souichi Takizawa, Toyoshi Endo, Shoichiro Tanaka, Masashi Takahashi, Tetsuro Kobayashi
- Organizer
  68th Scientific Sessions of American Diabetes Association
- Place of Presentation
  Chicago. USA
- Year and Date
  2008-06-16
- Data Source
  KAKENHI-PROJECT-19591041

1. KOBAYASHI Tetsuro (30113442)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
2. KANESHIGE Masahiro (20377518)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. TAKIZAWA Souichi (80456467)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. TANAKA Syoichiro (70377521)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. SHIMURA Hiroki (40303416)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 女屋敏正 (40020812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ENDO Toyoshi 遠藤 登代志

Research Projects

Research Products

Co-Researchers

Pathopysiology of fuluminant type 1 diabetes and development of its new therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of autoantibody against Amylaseα-2A in patients with fulminant type 1 diabetes mellitus and autoimmune pancreatitis, and its clinical use.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Early detection and diagnosis of fulminant type 1 diadetes mellitusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Organogenesis of pancreas in PDX-1 promoter/YFP transgenic mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

クラスII主要組織適合抗原発現誘導細胞によるバセドウ症眼症発症モデル動物の作成

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of thyroid function in rats specifically expressing MHC class II and B7.1 in the thyroidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Strucure and function of rat sodium/iodide symporter gene and its expression mechanism in the thyroidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the thyroid transcription factor-1(TTF-1) gene expression in thyroid neoplastic tissues.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular analysis of thyrotropin receptor in thyroid noeplasmPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

分子生物学に基づくサイロトロピンレセプター自己抗体の解析及び産生機序の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular cloning of cDNAs corresponding to mRNAs whchi increase in malignantly transformer FRTL cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Distinct cell clusters touching islet cells induce islet cell replication in association with over-expression of Regenerating Gene (REG) protein in fulminant type 1 diabetes.2014

Author(s)

Journal Title

Data Source

[Journal Article] Excess TSH causes abnormal skeletal development in young mice with hypothyroidism via suppressive effects on the growth plate.2013

Author(s)

Journal Title

Data Source

[Journal Article] Ligand-Bound Thyroid Hormone Receptor Contributes to Reprogramming of Pancreatic Acinar Cells Into Insulin-Producing Cells.2013

Author(s)

ENDO Toyoshi 遠藤登代志