SHIBAHARA Shigeki 柴原茂樹

… Alternative Names

SHIBAHARA SHIGEKI 柴原茂樹

Less

Researcher Number	00154253
Affiliation (based on the past Project Information) *help	2013: 東北大学, 大学院医学系研究科, 教授 2011 – 2013: 東北大学, 医学(系)研究科(研究院), 教授 2010: 東北大学, 大学院・医学系研究科, 教授 1987: Kyoto University,Faculty of Medicine, 医学部, 助手
Review Section/Research Field	Principal Investigator General medical chemistry Except Principal Investigator Pathological medical chemistry
Keywords	Principal Investigator 回避行動 / 網膜色素上皮細胞 / ストレス応答 / 生体防御 / MITF / L1エレメント / メラニン / 転写因子 / 網膜色素上皮 Except Principal Investigator ヘム … More / 翻訳後修飾 / アミノレブリン酸合成酵素 / cDNA Cloning / Ionic Channel / Neurotransmitter Receptor / Muscarinic Acetylcholine Receptor / Receptor for Calcium Channel Blockers / Sodium Channel / Nicotinic Acetylcholine Receptor / single-channel recording / 変異受容体 / εサブユニット / Naチャンネル / パッチクランプ法 / site-directed mutagenesis / CDNA発現 / CDNAクローニング / cDNA発現 / cDNAクローニング / イオンチャンネル / 神経伝達物質受容体 / ムスカリン性アセチルコリン受容体 / Ca^<2+>チャンネルブロッカー受容体 / Na^+チャンネル / ニコチン性アセチルコリン受容体 / 質量分析 / 翻訳後調節 / ５－アミノレブリン酸合成酵素 / 5-アミノレブリン酸合成酵素 / ミトコンドリア / 赤芽球 / SUMO / 鉄芽球性貧血 / 分子病態学 Less

Homeostasis of retinal pigment epithelium essential for survival of photorecptor cellsPrincipal Investigator
- Principal Investigator
  
  SHIBAHARA Shigeki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Regulatory mechanisms for heme biosynthesis in response to the change of regulatory heme pool.
- Principal Investigator
  
  FURUYAMA Kazumichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Iwate Medical University
  Tohoku University
Post-translational modification of erythroid-specific 5-aminolevulinate synthase and its' role in erythroid differentiation.
- Principal Investigator
  
  FURUYAMA Kazumichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
Studies on the Structure,Function and Gene Expression of Acetylcholine Receptors
- Principal Investigator
  
  NUMA SHOSAKU
- Project Period (FY)
  1983 – 1987
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Kyoto University

All 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Insertion of long interspersed element-1 in the Mitf gene is associated with altered neurobehavior of the black-eyed white Mitfmi-bw mouse.2014
- Author(s)
  Takeda K, Hozumi H, Nakai K, Yoshizawa M, Satoh H, Yamamoto H, Shibahara S.
- Journal Title
  
  Genes to Cells
  
  Volume: 19 Issue: 2 Pages: 126-140
- DOI
  10.1111/gtc.12117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659123
[Journal Article] Identification of a novel erythroid-specific enhancer for the ALAS2 gene and its loss-of-function mutation which is associated with congenital sideroblastic anemia2014
- Author(s)
  Kaneko K, Furuyama K, Fujiwara T, Kobayashi R, Ishida H, Harigae H, Shibahara S
- Journal Title
  
  Haematologica
  
  Volume: 99(2)(PubMed PMID : 23935018; PMCID : PMC3912954) Issue: 2 Pages: 252-261
- DOI
  10.3324/haematol.2013.085449
- Data Source
  KAKENHI-PROJECT-23590353
[Journal Article] Coordinated expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 and heme oxygenase 2: evidence for a regulatory link between glycolysis and heme catabolism.2012
- Author(s)
  Li B, Takeda K, Ishikawa K, Yoshizawa M, Sato M, Shibahara S, Furuyama K.
- Journal Title
  
  Tohoku J Exp Med.
  
  Volume: 228 Pages: 27-41
- NAID
  10031025395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590353
[Journal Article] Coordinated expression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 and heme oxygenase 2: evidence for a regulatory link between glycolysis and heme catabolism2012
- Author(s)
  Li B, Takeda K, Ishikawa K, Yoshizawa M, Sato M, Shibahara S, Furuyama K
- Journal Title
  
  Tohoku J Exp Med
  
  Volume: 228(1)(PMID : 22892400) Pages: 27-41
- NAID
  10031025395
- Data Source
  KAKENHI-PROJECT-23590353
[Journal Article] The carboxyl-terminal region of erythroid-specific 5-aminolevulinate synthase acts as an intrinsic modifier for its catalytic activity and protein stability.2012
- Author(s)
  Kadirvel S, Furuyama K, Harigae H, Kaneko K, Tamai Y, Ishida Y, Shibahara S.
- Journal Title
  
  Exp Hematol
  
  Volume: 40 Issue: 6 Pages: 477-486
- DOI
  10.1016/j.exphem.2012.01.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590353
[Journal Article] Otx2 is involved in the regional specification of the developing retinal pigment epithelium by preventing the expression of sox2 and fgf8, factors that induce neural retina differentiation2012
- Author(s)
  Daisuke Nishihara, Ichiro Yajima, Hiromasa Tabata, Masato Nakai, Nagaharu Tsukiji, Tatsuya Katahira, Kazuhisa Takeda, Shigeki Shibahara, Harukazu Nakamura, Hiroaki Yamamoto
- Journal Title
  
  PLoS One
  
  Volume: e48879 Issue: 11 Pages: e48879-e48879
- DOI
  10.1371/journal.pone.0048879
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J07029, KAKENHI-PROJECT-22570199, KAKENHI-PROJECT-24659123
[Journal Article] Lipocalin-type prostaglandin D synthase as a regulator of the retinoic acid signalling in melanocytes.2010
- Author(s)
  Takeda K, Takahashi NH, Yoshizawa M, Shibahara S.
- Journal Title
  
  J Biochem. vol.148
  
  Pages: 139-148
- NAID
  10027877446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Hypoxemia induces expression of heme oxygenase-1 and heme oxygenase-2 proteins in the mouse myocardium.2010
- Author(s)
  Han F, Takeda K, Ono M, Date F, Ishikawa K, Yokoyama S, Shinozawa Y, Furuyama K, Shibahara S.
- Journal Title
  
  J Biochem. vol.147
  
  Pages: 143-151
- NAID
  10027873503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Hypoxia induces erythroid-specific 5-aminolevulinate synthase expression in human erythroid cells through transforming growth factor-beta signaling2009
- Author(s)
  Kaneko K, Furuyama K, Aburatani H, Shibahara S
- Journal Title
  
  FEBS Journal 276
  
  Pages: 1370-1382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Hypoxia induces erythroid-specific 5-aminolevulinate synthase expression in human erythroid cells through transforming growth factor-beta signaling.2009
- Author(s)
  Kaneko K, Furuyama K, Aburatani H, Shibahara S.
- Journal Title
  
  FEBS J. vol.276
  
  Pages: 1370-1382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Induction of lipocalin-type prostaglandin D synthase in mouse heart under hypoxemia.2009
- Author(s)
  Han F, Takeda K, Ishikawa K, Ono M, Date F, Yokoyama S, Furuyama K, Shinozawa Y, Urade Y, Shibahara S.
- Journal Title
  
  Biochem Biophys Res Commun. vol.385
  
  Pages: 449-453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Mitf functions as an in ovo regulator for cell differentiation and proliferation during development of the chick RPE.2009
- Author(s)
  Tsukiji N, Nishihara D, Yajima I, Takeda K, Shibahara S, Yamamoto H.
- Journal Title
  
  Dev Biol. vol.326
  
  Pages: 335-346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Functional expression of heme oxygenase-1 in human differentiated epidermis and its regulation by cytokines.2009
- Author(s)
  Numata I, Okuyama R, Memezawa A, Ito Y, Takeda K, Furuyama K, Shibahara S, Aiba S.
- Journal Title
  
  J Invest Dermatol. vol.129
  
  Pages: 2594-2603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway2008
- Author(s)
  Vargas PD, Furuyama K, Sassa S, Shibahara S
- Journal Title
  
  FEBS Journal 275
  
  Pages: 5947-5959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway.2008
- Author(s)
  Vargas PD, Furuyama K, Sassa S, Shibahara S.
- Journal Title
  
  FEBS J. vol.75
  
  Pages: 5947-5959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Prostaglandin D2 induces heme oxygenase-1 mRNA expression through the DP2 receptor.2008
- Author(s)
  Satarug S, Wisedpanichkij R, Takeda K, Li B, Na-Bangchang K, Moore MR, Shibahara S.
- Journal Title
  
  Biochem Biophys Res Commun. vol.377
  
  Pages: 878-883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] Prostaglandin D2 induces heme oxygenase-1 in human retinal pigment epithelial cells.2008
- Author(s)
  Kuesap J, Li B, Satarug S, Takeda K, Numata I, Na-Bangchang K, Shibahara S.
- Journal Title
  
  Biochem Biophys Res Commun. vol.367
  
  Pages: 413-419
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Journal Article] A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces haem oxygenase-1 expression in human cells through a mechanism independent of hypoxia-inducible factor-lalpha.2008
- Author(s)
  Li B, Takeda K, Yokoyama S, Shibahara S.
- Journal Title
  
  J Biochem. vol.144
  
  Pages: 643-654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590301
[Presentation] black-eyed white Mitf^<mi-bw>mouseにおけるMitf-M mRNAのスプライシング異常と行動異常2013
- Author(s)
  武田和久、穂積大貴、仲井邦彦、吉澤美季、山本博章、柴原茂樹
- Organizer
  第25回日本色素細胞学会年次学術大会
- Place of Presentation
  大阪大学
- Data Source
  KAKENHI-PROJECT-24659123
[Presentation] black-eyed white Mitfmi-bw mouseにおけるMitf-M mRNAのスプライシング異常と行動異常2013
- Author(s)
  武田和久、穂積大貴、仲井邦彦、吉澤美季、山本博章、柴原茂樹
- Organizer
  第25回日本色素細胞学会年次学術大会
- Place of Presentation
  大阪大学
- Data Source
  KAKENHI-PROJECT-24659123
[Presentation] An insertion of long interspersed element-1 in the Mitf gene is associated with altered volitional motor activity of the black-eyed white Mitfmi-bw mouse2013
- Author(s)
  Takeda K, Hozumi H, Nakai K, Yoshizawa M, Satoh H, Yamamoto H, Shibahara S.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜パシフィコ
- Data Source
  KAKENHI-PROJECT-24659123
[Presentation] An insertion of long interspersed element-1 in the Mitf gene is associated with altered volitional motor activity of the black-eyed white Mitf^<mi-bw>mouse2013
- Author(s)
  Kazuhisa Takeda, Hiroki Hozumi, Kunihiko Nakai, Miki Yoshizawa, Hiroshi Satoh, Hiroaki Yamamoto, Shigeki Shibahara
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜パシフィコ
- Data Source
  KAKENHI-PROJECT-24659123
[Presentation] Identification of the Novel Erythroid-Specific Enhancer in the First Intron of Human ALAS2 Gene; Tthe Mutation Disrupting GATA Transcription Factor-Binding Site in the Enhancer Causes X-Linked Sideroblastic Anemia.2012
- Author(s)
  Furuyama K, Kaneko K, Fujiwara T, Harigae H, Shibahara S.
- Organizer
  54th Annual Meeting of American Society of Hematology
- Place of Presentation
  Atlanta, U.S.A.
- Data Source
  KAKENHI-PROJECT-23590353
[Presentation] 聴覚•色素異常を呈するblack-eyed white Mitf^<mi-bw>mouseのメラノブラスト分化異常2012
- Author(s)
  穂積大貴、武田和久、天野恭子、東谷篤志、山本博章、柴原茂樹
- Organizer
  第35回日本分子生物学会年次学術大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24659123
[Presentation] Melanocyte-specific Mitf-M is a key regulator for development of melanoblasts : Lessons from the black-eyed white Mitf^<mi-bw>mouse2012
- Author(s)
  Kazuhisa Takeda, Hiroki Hozumi, Yasuko Yoshida-Amano, Atushi Higashitani, Hiroaki Yamamoto, Shigeki Shibahara
- Organizer
  第24回日本色素細胞学会年次学術大会
- Place of Presentation
  長浜バイオ大学
- Data Source
  KAKENHI-PROJECT-24659123
[Presentation] Identification of the Novel Erythroid-Specific Enhancer in the First Intron of Human ALAS2 Gene;The Mutation Disrupting GATA Transcription Factor-Binding Site in the Enhancer Causes X-Linked Sideroblastic Anemia2012
- Author(s)
  Furuyama K, Kaneko K, Fujiwara T, Harigae H, Shibahara S
- Organizer
  54th Annual Meeting of American Society of Hematology
- Place of Presentation
  Atlanta, U.S.A
- Data Source
  KAKENHI-PROJECT-23590353
[Presentation] ヒト赤芽球特異的5−アミノレブリン酸合成酵素遺伝子における新たな赤芽球特異的エンハンサーの同定2012
- Author(s)
  古山和道, 金子桐子, 藤原亨, 張替秀郎, 柴原茂樹
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23590353
[Presentation] Melanocyte-specific Mitf-M is a key regulator for development of melanoblasts: Lessons from the black-eyed white Mitfmi-bw mouse2012
- Author(s)
  Kazuhisa Takeda, Hiroki Hozumi, Yasuko Yoshida-Amano, Atushi Higashitani, Hiroaki Yamamoto, Shigeki Shibahara
- Organizer
  第24回日本色素細胞学会年次学術大会
- Place of Presentation
  長浜市田村町長浜バイオ大学
- Data Source
  KAKENHI-PROJECT-24659123
[Presentation] ヒト赤芽球特異的5-アミノレブリン酸合成酵素遺伝子における新たな赤芽球特異的エンハンサーの同定2012
- Author(s)
  古山和道、金子桐子、藤原亨、張替秀郎、柴原茂樹.
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590353
[Presentation] 聴覚・色素異常を呈するblack-eyed white Mitfmi-bw mouseのメラノブラスト分化異常2012
- Author(s)
  穂積大貴、武田和久、天野恭子、東谷篤志、山本博章、柴原茂樹
- Organizer
  第35回日本分子生物学会年次学術大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24659123
[Presentation] 赤芽球特異的5−アミノレブリン酸合成酵素のカルボキシル末端は内因性抑制ドメインとして機能する2011
- Author(s)
  Senkottubelan Kadirvel,古山和道, 金子桐子, 張替秀郎, 柴原茂樹
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-23590353
[Presentation] 低酸素刺激によるヘモグロビン合成誘導機構2008
- Author(s)
  金子桐子、古山和道、柴原茂樹
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20590301
[Presentation] 赤芽球特異的5-アミノレブリン酸合成酵素のカルボキシル末端は内因性抑制ドメインとして機能する
- Author(s)
  Senkottubelan Kadirvel, 古山和道、金子桐子、張替秀郎、柴原茂樹
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-23590353

1. FURUYAMA Kazumichi (80280874)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
2. KANEKO Kiriko (10545784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. TAKEDA Kazuhisa (30311559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. YOSHIZAWA Miki (50221669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NUMA SHOSAKU (50025516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KUBO TAI (10178030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NODA MASAHARU (60172798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MISHINA MASAYOSHI (80144351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 柴原茂樹 (70206142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 吉沢美季

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results

SHIBAHARA Shigeki 柴原 茂樹

SHIBAHARA SHIGEKI 柴原 茂樹

Research Projects

Research Products

Co-Researchers

Homeostasis of retinal pigment epithelium essential for survival of photorecptor cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulatory mechanisms for heme biosynthesis in response to the change of regulatory heme pool.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Post-translational modification of erythroid-specific 5-aminolevulinate synthase and its' role in erythroid differentiation.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the Structure,Function and Gene Expression of Acetylcholine Receptors

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] Insertion of long interspersed element-1 in the Mitf gene is associated with altered neurobehavior of the black-eyed white Mitfmi-bw mouse.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of a novel erythroid-specific enhancer for the ALAS2 gene and its loss-of-function mutation which is associated with congenital sideroblastic anemia2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Coordinated expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 and heme oxygenase 2: evidence for a regulatory link between glycolysis and heme catabolism.2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Coordinated expression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 and heme oxygenase 2: evidence for a regulatory link between glycolysis and heme catabolism2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] The carboxyl-terminal region of erythroid-specific 5-aminolevulinate synthase acts as an intrinsic modifier for its catalytic activity and protein stability.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Otx2 is involved in the regional specification of the developing retinal pigment epithelium by preventing the expression of sox2 and fgf8, factors that induce neural retina differentiation2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipocalin-type prostaglandin D synthase as a regulator of the retinoic acid signalling in melanocytes.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Hypoxemia induces expression of heme oxygenase-1 and heme oxygenase-2 proteins in the mouse myocardium.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Hypoxia induces erythroid-specific 5-aminolevulinate synthase expression in human erythroid cells through transforming growth factor-beta signaling2009

Author(s)

Journal Title

Data Source

[Journal Article] Hypoxia induces erythroid-specific 5-aminolevulinate synthase expression in human erythroid cells through transforming growth factor-beta signaling.2009

Author(s)

Journal Title

Data Source

[Journal Article] Induction of lipocalin-type prostaglandin D synthase in mouse heart under hypoxemia.2009

Author(s)

Journal Title

Data Source

SHIBAHARA Shigeki 柴原茂樹

SHIBAHARA SHIGEKI 柴原茂樹