Takashima Akihiko 高島明彦

… Alternative Names

TAKASHIMA Akihiko 高島明彦

Less

Researcher Number	00154774
Other IDs
Affiliation (Current)	2025: 学習院大学, 理学部, 教授 2025: 藤田医科大学, 医学部, 客員教授 2025: 国立研究開発法人国立長寿医療研究センター, その他部局, その他
Affiliation (based on the past Project Information) *help	2016 – 2023: 学習院大学, 理学部, 教授 2015: 国立研究開発法人国立長寿医療研究センター, 分子基盤研究部, 部長 2012 – 2014: 独立行政法人国立長寿医療研究センター, 分子基盤研究部, 部長 2013: 国立長寿医療研究センター, 部長 2008 – 2009: The Institute of Physical and Chemical Research, アルツハイマー病研究チーム, チームリーダー … More 2007: The Institute of Physical and Chemical Research, アルツハイマー病研究チーム, チームリーダー 2003 – 2006: 独立行政法人理化学研究所, アルツハイマー病研究チーム, チームリーダー 2005: RIKEN, BSI, Lab., Alzheimer's disease, Team Leader, 脳科学総合研究センター, チームリーダー 2004: 独立行政法人理化学研究所, アルツハイマー病研究チーム・チームリダー 2002: 理化学研究所, アルツハイマー病研究チーム, チームリーダー 2001: 理化学研究所, アルツハイマー病研究チーム, チームリーダー(研究員) 2000 – 2001: 理化学研究所, アルツハイマー病研究チーム, チームリーダー(研究職) 1986 – 1988: 佐賀医科大学, 医学部, 教務員 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Biological Sciences / Nerve anatomy/Neuropathology Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Complex systems / General medical chemistry / 動物発生・生理学 / Psychiatric science / Nerve anatomy/Neuropathology / Biological pharmacy / Biological Sciences
Keywords	Principal Investigator アルツハイマー病 / タウ / 老化 / 神経変性 / 神経原線維 / JNK / Aβ / GSK-3β / 神経原繊維 / FTDP17 … More / 神経原線維変化 / Presenilin / Aging / Tau / Neurofibrillary tangles / GSK-3 / Alzheimer's disease / 行動異常 / マウスモデル / FTDP-17 / 痴呆 / 細胞骨格 / プレセニリン / β-アミロイド / 樹状突起 / 過活動 / 局在 / 脳神経疾患 / 神経科学 / 神経細胞死 / リン酸化 / 凝集 / 脳機能 / 認知症 / タウタンパク質 / AMPA / 過剰リン酸化 / NMDA / LTD / シナプス / マウス / 細胞周期 / テロメア結合因子 / 神経細胞 / モデルマウス / テロメレース / テロメア / 脳 / 変異タウ / 遺伝子改変動物 … More Except Principal Investigator アルツハイマー病 / 脳神経疾患 / タウ / FTDP-17 / Alzheimer's disease / タウタンパク質 / 受容体 / 神経成長因子 / 老化ミクログリア / DAMPs / エクソソーム / 内耳細胞死 / 酸化ストレス / SASP / オートファジー / 内耳細胞老化 / LaminB1 / cGAS-STING / Nucleophagy / NaAsO2 / プローブ / シンギュラリティ生物学 / イメージング / ゲノム編集 / タンパク質凝集 / プローブ開発 / １分子イメージング / 光遺伝学 / シンギュラリティ / 脳 / 老化 / 神経変性疾患 / Neurotransmitter / Potassium / Receptor / Neurite outgrowth / Pheochromocytoma / Nerve growth factor / Ca^<2+>チャンネル / カテコーラミン / Ca^<2+>イオン / GTPアナログ / 褐色細胞種 / GTP結合蛋白質 / 神経伝達物質 / K^+イオン / 突起成長 / 褐色細胞腫 / frontotemporal dementia / tau / neurofibrillary tangle / senile change / neurogenesis / dentate gyrus / depression / 髄液 / モデル動物 / 神経新生 / 前頭側頭型痴呆 / 神経原線維変化 / 老年性変化 / 神経細胞新生 / 海馬歯状回 / うつ病 / neuronal cell death / yeast two-hybrid / tau protein / Yeast Two-hybrid / 神経原繊維変化 / 酵母two-hybrid / 神経細胞死 / 酵母Two-hybrid / タウ蛋白質 / FTDP17 / 環状リン酸 / 細胞周期 / カテコールアミン / 脱分極 / 取り込み / 結合 / 脂質 / 認知症 / 生化学 / 神経科学 / 分泌変異株 / sec / 酵母 / αセクレターゼ / APP / アミロイドβ Less

内耳細胞死由来エクソソーム・DAMPsが海馬の空間情報処理に及ぼす影響の解明
- Principal Investigator
  
  林賢
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Keio University
Research on the molecular mechanism of singularity phenomenon in neurological disorders
- Principal Investigator
  
  Bannai Hiroko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Waseda University
The expression analysis of Tau protein in hiPSC-derived neurons or directly converted neurons from fibroblasts
- Principal Investigator
  
  Maeda Sumihiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General medical chemistry
- Research Institution
  Keio University
Mechanism of tau protein aging and neurodegenerationPrincipal Investigator
- Principal Investigator
  
  Takashima Akihiko
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Gakushuin University
  National Center for Geriatrics and Gerontology
シナプス活動を介した神経原線維変化形成機構Principal Investigator
- Principal Investigator
  
  高島明彦
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Center for Geriatrics and Gerontology
Tau aggregation regulated by membrane lipid
- Principal Investigator
  
  SUMIOKA Akio
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biological pharmacy
- Research Institution
  National Center for Geriatrics and Gerontology
神経原線維変化形成機構Principal Investigator
- Principal Investigator
  
  高島明彦
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
神経原線維変化形成機構Principal Investigator
- Principal Investigator
  
  高島明彦
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
神経原線維変化形成機構Principal Investigator
- Principal Investigator
  
  高島明彦
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Investigation on candidate genes involved in pathophysiology of schizophrenia
- Principal Investigator
  
  TATEBAYASHI Yositaka
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Tokyo Institute of Psychiatry
アミロイド前駆体タンパク質(APP)の細胞内輸送とプロセシング
- Principal Investigator
  
  村上明子
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Mechanism of NFT formationPrincipal Investigator
- Principal Investigator
  
  TAKASHIMA Akihiko
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  RIKEN
神経原線維変化生成機序Principal Investigator
- Principal Investigator
  
  高島明彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
老化に伴う脳神経細胞のテロメア動態Principal Investigator
- Principal Investigator
  
  高島明彦
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The Institute of Physical and Chemical Research
Role of tau protein for neurodegeneration in Alzheimer's disease
- Principal Investigator
  
  MURAYAMA Ohoshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Azabu University
  The Institute of Physical and Chemical Research
Regulatory Mechanisms of Cellular Responses to Nerve Growth Factor(NGF) --Studies on the Interaction between NGF and NGF Receptors--
- Principal Investigator
  
  TANAKA Shuitsu, 小池達郎
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  動物発生・生理学
- Research Institution
  Saga Medical School
神経成長因子受容体の構造と機能
- Principal Investigator
  
  KOIKE Tatsuro
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  佐賀医科大学

[Book] Tau Biology2019
- Author(s)
  Takashima A, Wolozin B, Buee L.
- Total Pages
  416
- Publisher
  Springer Nature
- ISBN
  9789813293588
- Data Source
  KAKENHI-PLANNED-18H05414
[Book] HUMAN SCIENCE Vol.24 No.22013
- Author(s)
  高島明彦
- Total Pages
  36
- Publisher
  公益財団法人ヒューマンサイエンス振興財団
- Data Source
  KAKENHI-PUBLICLY-24111562
[Book] Psychiatry Today No.312013
- Author(s)
  高島明彦
- Total Pages
  28
- Publisher
  Medical Front International Limited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Book] 細胞工学Vol.312012
- Author(s)
  高島明彦
- Total Pages
  108
- Publisher
  学研メディカル秀潤社
- Data Source
  KAKENHI-PUBLICLY-24111562
[Journal Article] Dendritic distribution of CDK5 mRNA and p35 mRNA, and a glutamate-responsive increase of CDK5/p25 complex contribute to tau hyperphosphorylation2022
- Author(s)
  Tanaka Toru、Ohashi Sachiyo、Takashima Akihiko、Kobayashi Shunsuke
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1866 Issue: 7 Pages: 130135-130135
- DOI
  10.1016/j.bbagen.2022.130135
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05414, KAKENHI-PROJECT-20K15999
[Journal Article] Administration of mucuna beans (Mucuna pruriences (L.) DC. var. utilis) improves cognition and neuropathology of 3?×?Tg-AD mice2022
- Author(s)
  Konishi Fumiko、Furusho Tadasu、Soeda Yoshiyuki、Yamauchi Jun、Kobayashi Shoko、Ito Masatoshi、Araki Takuma、Kogure Sarasa、Takashima Akihiko、Takekoshi Susumu
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 996-996
- DOI
  10.1038/s41598-022-04777-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05414, KAKENHI-PROJECT-20K06896
[Journal Article] Disulfide bond formation in microtubule-associated tau protein promotes tau accumulation and toxicity <i>in vivo</i>2021
- Author(s)
  Saito Taro、Chiku Tomoki、Oka Mikiko、Wada-Kakuda Satoko、Nobuhara Mika、Oba Toshiya、Shinno Kanako、Abe Saori、Asada Akiko、Sumioka Akio、Takashima Akihiko、Miyasaka Tomohiro、Ando Kanae
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 30 Issue: 21 Pages: 1955-1967
- DOI
  10.1093/hmg/ddab162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21593, KAKENHI-PLANNED-18H05414
[Journal Article] Deposition of Phosphorylated α-Synuclein and Activation of GSK-3β and PP2A in the PS19 Mouse Model of Tauopathy2021
- Author(s)
  Takaichi Yuta、Chambers James K、Ano Yasuhisa、Takashima Akihiko、Nakayama Hiroyuki、Uchida Kazuyuki
- Journal Title
  
  Journal of Neuropathology & Experimental Neurology
  
  Volume: 80 Issue: 8 Pages: 731-740
- DOI
  10.1093/jnen/nlab054
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05414, KAKENHI-PROJECT-18H02338, KAKENHI-PROJECT-19J22779
[Journal Article] β-Lactolin Reduces Age-Related Inflammation and Cognitive Decline2021
- Author(s)
  Ano Yasuhisa、Ohya Rena、Takashima Akihiko、Uchida Kazuyuki、Nakayama Hiroyuki
- Journal Title
  
  Frontiers in Nutrition
  
  Volume: 8 Pages: 724134-724134
- DOI
  10.3389/fnut.2021.724134
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05414
[Journal Article] Essential roles of plexin-B3(+) oligodendrocyte precursor cells in the pathogenesis of Alzheimer's disease.2021
- Author(s)
  Nihonmatsu-Kikuchi N, Yu XJ, Matsuda Y, Ozawa N, Ito T, Satou K, Kaname T, Iwasaki Y, Akagi A, Yoshida M, Toru S, Hirokawa K, Takashima A, Hasegawa M, Uchihara T, Tatebayashi Y
- Journal Title
  
  Commun Biol
  
  Volume: 4 Issue: 1 Pages: 870-870
- DOI
  10.1038/s42003-021-02404-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03555, KAKENHI-PLANNED-18H05414, KAKENHI-PROJECT-16H06277
[Journal Article] β-Lactolin, a Whey-Derived Lacto-Tetrapeptide, Prevents Alzheimer’s Disease Pathologies and Cognitive Decline2020
- Author(s)
  Ano Yasuhisa、Ohya Rena、Takaichi Yuta、Washinuma Terukatsu、Uchida Kazuyuki、Takashima Akihiko、Nakayama Hiroyuki
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 73 Issue: 4 Pages: 1331-1342
- DOI
  10.3233/jad-190997
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05414
[Journal Article] Glutamate-responsive translation of dendritic GSK3β mRNA triggers a cycle for amplification of reactivated preexisting GSK3β that is indispensable for tau hyperphosphorylation2020
- Author(s)
  Tanaka Toru、Ohashi Sachiyo、Takashima Akihiko、Kobayashi Shunsuke
- Journal Title
  
  Neurochemistry International
  
  Volume: 139 Pages: 104808-104808
- DOI
  10.1016/j.neuint.2020.104808
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05414
[Journal Article] Hop bitter acids containing a β-carbonyl moiety prevent inflammation-induced cognitive decline via the vagus nerve and noradrenergic system2020
- Author(s)
  Ano Yasuhisa、Ohya Rena、Yamazaki Takahiro、Takahashi Chika、Taniguchi Yoshimasa、Kondo Keiji、Takashima Akihiko、Uchida Kazuyuki、Nakayama Hiroyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 20028-20028
- DOI
  10.1038/s41598-020-77034-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05414
[Journal Article] New Insights Into Drug Discovery Targeting Tau Protein2020
- Author(s)
  Yoshiyuki Soeda, Akihiko Takashima
- Journal Title
  
  Front Mol Neurosci
  
  Volume: 13 Pages: 590896-590896
- DOI
  10.3389/fnmol.2020.590896
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06896, KAKENHI-PLANNED-18H05414
[Journal Article] Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy2020
- Author(s)
  Takaichi Yuta、Chambers James K.、Inoue Hiroyuki、Ano Yasuhisa、Takashima Akihiko、Nakayama Hiroyuki、Uchida Kazuyuki
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 8 Issue: 1 Pages: 86-86
- DOI
  10.1186/s40478-020-00969-8
- NAID
  120006902252
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05414, KAKENHI-PROJECT-18H02338, KAKENHI-PROJECT-19J22779
[Journal Article] Tryptophan-related Dipeptides in Fermented Dairy Products Suppress Microglial Activation and Prevent Cognitive Decline2019
- Author(s)
  Ano Y, Yoshino Y, Kutsukake T, Ohya R, Fukuda T, Uchida K, Takashima A, Nakayama H
- Journal Title
  
  Aging
  
  Volume: 11 Issue: 10 Pages: 2949-2967
- DOI
  10.18632/aging.101909
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05414
[Journal Article] Enhanced Tau Protein Translation by Hyper-Excitation2019
- Author(s)
  Kobayashi S, Tanaka T, Soeda Y, Takashima A.
- Journal Title
  
  Front Aging Neurosci,
  
  Volume: 11 Pages: 322-322
- DOI
  10.3389/fnagi.2019.00322
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05414
[Journal Article] Iso-α-Acids, Bitter Components in Beer, Suppress Inflammatory Responses and Attenuate Neural Hyperactivation in the Hippocampus2019
- Author(s)
  Ano Yasuhisa、Yoshikawa Misato、Takaichi Yuta、Michikawa Makoto、Uchida Kazuyuki、Nakayama Hiroyuki、Takashima Akihiko
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 10 Pages: 81-81
- DOI
  10.3389/fphar.2019.00081
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-19J22779
[Journal Article] Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs2019
- Author(s)
  Nakamura Mari、Shiozawa Seiji、Tsuboi Daisuke、Amano Mutsuki、Watanabe Hirotaka、Maeda Sumihiro、Kimura Taeko、Yoshimatsu Sho、Kisa Fumihiko、Karch Celeste M.、Miyasaka Tomohiro、Takashima Akihiko、Sahara Naruhiko、Hisanaga Shin-ichi、Ikeuchi Takeshi、Kaibuchi Kozo、Okano Hideyuki
- Journal Title
  
  Stem Cell Reports
  
  Volume: 13 Issue: 4 Pages: 684-699
- DOI
  10.1016/j.stemcr.2019.08.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06472, KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-19J12871, KAKENHI-PROJECT-17K08668, KAKENHI-PROJECT-17K07383, KAKENHI-PLANNED-18H05414
[Journal Article] Tau Oligomers2019
- Author(s)
  Maeda S, Takashima A.
- Journal Title
  
  Adv Exp Med Biol .
  
  Volume: 1184 Pages: 373-380
- DOI
  10.1007/978-981-32-9358-8_27
- ISBN
  9789813293571, 9789813293588
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05414
[Journal Article] Methylene Blue Inhibits Formation of Tau Fibrils but not of Granular Tau Oligomers: A Plausible Key to Understanding Failure of a Clinical Trial for Alzheimer’s Disease2019
- Author(s)
  Soeda Yoshiyuki、Saito Marino、Maeda Sumihiro、Ishida Kohki、Nakamura Akira、Kojima Shuichi、Takashima Akihiko
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 68 Issue: 4 Pages: 1677-1686
- DOI
  10.3233/jad-181001
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-17H07087, KAKENHI-PLANNED-18H05414
[Journal Article] Deposition of Phosphorylated α-Synuclein in the rTg4510 Mouse Model of Tauopathy2018
- Author(s)
  Takaichi Yuta、Ano Yasuhisa、Chambers James K、Uchida Kazuyuki、Takashima Akihiko、Nakayama Hiroyuki
- Journal Title
  
  Journal of Neuropathology & Experimental Neurology
  
  Volume: 77 Issue: 10 Pages: 920-928
- DOI
  10.1093/jnen/nly070
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-18H02338
[Journal Article] Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory2018
- Author(s)
  Yoshikawa Misato、Soeda Yoshiyuki、Michikawa Makoto、Almeida Osborne F. X.、Takashima Akihiko
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 12 Pages: 124-124
- DOI
  10.3389/fnins.2018.00124
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15712, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16H05559
[Journal Article] Novel lactopeptides in fermented dairy products improve memory function and cognitive decline2018
- Author(s)
  Ano Yasuhisa、Ayabe Tatsuhiro、Kutsukake Toshiko、Ohya Rena、Takaichi Yuta、Uchida Shinichi、Yamada Koji、Uchida Kazuyuki、Takashima Akihiko、Nakayama Hiroyuki
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 72 Pages: 23-31
- DOI
  10.1016/j.neurobiolaging.2018.07.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117004
[Journal Article] Distribution of endogenous normal tau in the mouse brain2018
- Author(s)
  Kubo Atsuko、Misonou Hiroaki、Matsuyama Makoto、Nomori Akane、Wada-Kakuda Satoko、Takashima Akihiko、Kawata Mitsuhiro、Murayama Shigeo、Ihara Yasuo、Miyasaka Tomohiro
- Journal Title
  
  Journal of Comparative Neurology
  
  Volume: 527 Issue: 5 Pages: 985-998
- DOI
  10.1002/cne.24577
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16H06277, KAKENHI-PLANNED-18H05414
[Journal Article] Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology2018
- Author(s)
  Silva Joana Margarida、Rodrigues Sara、Sampaio-Marques B、Gomes Patr?cia、Neves-Carvalho Andreia、Dioli Chrysoula、Soares-Cunha Carina、Mazuik Brandon F、Takashima Akihiko、Ludovico Paula、Wolozin Benjamin、Sousa Nuno、Sotiropoulos Ioannis
- Journal Title
  
  Cell Death & Differentiation
  
  Volume: - Issue: 8 Pages: 1411-1427
- DOI
  10.1038/s41418-018-0217-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-18H05414
[Journal Article] Frontotemporal dementia with Parkinsonism linked to chromosome-17 mutations enhance tau oligomer formation2018
- Author(s)
  Maeda Sumihiro、Sato Yuhei、Takashima Akihiko
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 69 Pages: 26-32
- DOI
  10.1016/j.neurobiolaging.2018.04.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-17H07087
[Journal Article] Iso-α-Acids, the Bitter Components of Beer, Suppress Microglial Inflammation in rTg4510 Tauopathy2018
- Author(s)
  Ano Yasuhisa、Takaichi Yuta、Uchida Kazuyuki、Kondo Keiji、Nakayama Hiroyuki、Takashima Akihiko
- Journal Title
  
  Molecules
  
  Volume: 23 Issue: 12 Pages: 3133-3133
- DOI
  10.3390/molecules23123133
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117004
[Journal Article] Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging.2017
- Author(s)
  Yagishita S, Suzuki S, Yoshikawa K, Iida K, Hirata A, Suzuki M, Takashima A, Maruyama K, Hirasawa A, Awaji T.
- Journal Title
  
  Mol Brain
  
  Volume: 10 Issue: 1 Pages: 2-2
- DOI
  10.1186/s13041-016-0282-7
- NAID
  120005971848
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460341, KAKENHI-PROJECT-25870677, KAKENHI-PROJECT-16K15777, KAKENHI-PROJECT-16K21328, KAKENHI-PLANNED-26117004
[Journal Article] Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes2017
- Author(s)
  Maekawa M、Watanabe A、Iwayama Y、Kimura T、Hamazaki K、Balan S、Ohba H、Hisano Y、Nozaki Y、Ohnishi T、Toyoshima M、Shimamoto C、Iwamoto K、Bundo M、Osumi N、Takahashi E、Takashima A、Yoshikawa T
- Journal Title
  
  Transl Psychiatry.
  
  Volume: 7 Issue: 9 Pages: e1229-e1229
- DOI
  10.1038/tp.2017.182
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19372, KAKENHI-PLANNED-16H06399, KAKENHI-PLANNED-16H06530, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15H04891, KAKENHI-PROJECT-15K09814
[Journal Article] Local somatodendritic translation and hyperphosphorylation of tau protein triggered by AMPA and NMDA receptor stimulation2017
- Author(s)
  Shunsuke Kobayashi, Toru Tanaka, Yoshiyuki Soeda, Osborne F. X. Almeida, Akihiko Takashima
- Journal Title
  
  Ebio medicine
  
  Volume: 印刷中 Pages: 120-126
- DOI
  10.1016/j.ebiom.2017.05.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117004
[Journal Article] Altered tau isoform ratio caused by loss of Fus and Sfpq function leads to FTLD-like phenotypes2017
- Author(s)
  Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okado H, Katsuno H, Sobue G.
- Journal Title
  
  Cell Reports
  
  Volume: 18 Issue: 5 Pages: 1118-1131
- DOI
  10.1016/j.celrep.2017.01.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01568, KAKENHI-PLANNED-26117002, KAKENHI-PLANNED-26117007, KAKENHI-PROJECT-26290016, KAKENHI-PROJECT-16K15480, KAKENHI-PROJECT-25640038, KAKENHI-PROJECT-16K14569, KAKENHI-PROJECT-17K09753, KAKENHI-ORGANIZER-26117001, KAKENHI-PROJECT-15H04278, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-17H04195, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09310
[Journal Article] Iso-α-acids, Bitter Components of Beer, Prevent Inflammation and Cognitive Decline Induced in a Mouse Model of Alzheimer's Disease.2017
- Author(s)
  Ano Y, Dohata A, Taniguchi Y, Hoshi A, Uchida K, Takashima A, Nakayama H.
- Journal Title
  
  J Biol Chem.
  
  Volume: 292 Issue: 9 Pages: 3720-3728
- DOI
  10.1074/jbc.m116.763813
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117004
[Journal Article] Mechanism of neurodegeneration through tau and therapy for Alzheimer disease.2016
- Author(s)
  Takashima A
- Journal Title
  
  Journal of Sport and Health Science
  
  Volume: 5 Issue: 4 Pages: 391-392
- DOI
  10.1016/j.jshs.2016.08.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117004
[Journal Article] The Advantages of Structural Equation Modeling to Address the Complexity of Spatial Reference Learning.2016
- Author(s)
  Moreira PS, Sotiropoulos I, Silva J, Takashima A, Sousa N, Leite-Almeida H, Costa PS.
- Journal Title
  
  Front Behav Neurosci.
  
  Volume: 10 Pages: 18-18
- DOI
  10.3389/fnbeh.2016.00018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117004
[Journal Article] Modification of tau by 8-nitro-cGMP: effects of nitric oxide-linked chemical modification on tau aggregation2016
- Author(s)
  Yoshitake J, Soeda Y, Ida T, Sumioka A, Yoshikawa M, Matsushita K, Akaike T, Takashima A.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 43 Pages: 22714-22720
- DOI
  10.1074/jbc.m116.734350
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111008, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-15K20876
[Journal Article] Glycogen Synthase Kinase 3β-mediated Phosphorylation in the Most C-terminal Region of Protein Interacting with C Kinase 1 (PICK1) Regulates the Binding of PICK1 to Glutamate Receptor Subunit GluA22015
- Author(s)
  Yagishita S, Murayama M, Ebihara T, Maruyama K, Takashima A
- Journal Title
  
  J Biol Chem.
  
  Volume: 290 Issue: 49 Pages: 29438-48
- DOI
  10.1074/jbc.m114.619668
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460341, KAKENHI-PLANNED-26117004
[Journal Article] Female Hippocampus Vulnerability to Environmental Stress as Precipitating Factor in Tau Aggregation Pathology.2015
- Author(s)
  Sotiropoulos I, Silva J, Kimura T, Rodrigues AJ, Costa P, Almeida OF, Sousa N, Takashima A.
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 43 Issue: 3 Pages: 763-774
- DOI
  10.3233/jad-140693
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117004
[Journal Article] Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups.2015
- Author(s)
  Soeda Y, Yoshikawa M, Almeida OF, Sumioka A, Maeda S, Osada H, Kondoh Y, Saito A, Miyasaka T, Kimura T, Suzuki M, Koyama H, Yoshiike Y, Sugimoto H, Ihara Y, Takashima A
- Journal Title
  
  Nat Commun
  
  Volume: 6 Issue: 1 Pages: 10216-10216
- DOI
  10.1038/ncomms10216
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350976, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway2015
- Author(s)
  Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 24(17) Issue: 17 Pages: 4879-4900
- DOI
  10.1093/hmg/ddv212
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06777, KAKENHI-PROJECT-25640038, KAKENHI-PUBLICLY-15H01565, KAKENHI-PUBLICLY-15H01568, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15H04278, KAKENHI-PLANNED-26117007
[Journal Article] Development of disease modifying drugs for dementia—focusing on anti-tau drugs—2014
- Author(s)
  添田義行,　高島明彦
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 54 Issue: 12 Pages: 1178-1180
- DOI
  10.5692/clinicalneurol.54.1178
- NAID
  130004921162
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Data Source
  KAKENHI-PLANNED-26117004
[Journal Article] Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice.2014
- Author(s)
  Umeda T, Maekawa S, Kimura T, Takashima A, Tomiyama T, Mori H.
- Journal Title
  
  Acta Neuropathol.
  
  Volume: 127(5) Issue: 5 Pages: 685-98
- DOI
  10.1007/s00401-014-1259-1
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111562, KAKENHI-PROJECT-24659434, KAKENHI-PROJECT-25290018, KAKENHI-PLANNED-26117004
[Journal Article] Biochemical Distribution of Tau Protein in Synaptosomal Fraction of Transgenic Mice Expressing Human P301L Tau2014
- Author(s)
  Sahara N, Murayama M, Higuchi M, Suhara T, Takashima A.
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 5 Pages: 26-26
- DOI
  10.3389/fneur.2014.00026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PUBLICLY-24111562, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117008
[Journal Article] Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls2013
- Author(s)
  Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, Furumoto S, Kudo Y, Chang Q, Saido TC, Takashima A, Lewis J, Jang MK, Aoki I, Ito H, Higuchi M.
- Journal Title
  
  Neuron
  
  Volume: 79 Issue: 6 Pages: 1094-1108
- DOI
  10.1016/j.neuron.2013.07.037
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-23591735, KAKENHI-PUBLICLY-24111562, KAKENHI-PROJECT-25670524
[Journal Article] Microtubule-associated protein tau is essential for long-term depression in the hippocampus.2013
- Author(s)
  Kimura T, Whitcomb DJ, Jo J, Regan P, Piers T, Heo S, Brown C, Hashikawa T, Murayama M, Seok H, Sotiropoulos I, Kim E, Collingridge GL, Takashima A, and Cho K.
- Journal Title
  
  Philos Trans R Soc Lond B Biol Sci.
  
  Volume: 369(1633) Issue: 1633 Pages: 20130144-20130144
- DOI
  10.1098/rstb.2013.0144
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111562
[Journal Article] Neurodegenerative disorder FTDP-17-related tau intron 10 +16C → T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice.2013
- Author(s)
  Umeda T, Yamashita T, Kimura T, Ohnishi K, Takuma H, Ozeki T, Takashima A, Tomiyama T, Mori H.
- Journal Title
  
  Am J Pathol.
  
  Volume: 183(1) Issue: 1 Pages: 211-25
- DOI
  10.1016/j.ajpath.2013.03.015
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111562, KAKENHI-PROJECT-24659434, KAKENHI-PROJECT-25290018, KAKENHI-PROJECT-25461266
[Journal Article] Tauopathies and tau oligomers.2013
- Author(s)
  Takashima A.
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 37(3) Issue: 3 Pages: 565-8
- DOI
  10.3233/jad-130653
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111562
[Journal Article] Acceleration of bone development and regeneration through the Wnt/β-catenin signaling pathway in mice heterozygously deficient for GSK-3β.2013
- Author(s)
  Arioka M, Takahashi-Yanaga F, Sasaki M, Yoshihara T, Morimoto S, Takashima A, Mori Y, Sasaguri T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 440(4) Issue: 4 Pages: 677-82
- DOI
  10.1016/j.bbrc.2013.09.126
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111562, KAKENHI-PROJECT-25463090
[Journal Article] GSK-3β and memory formation2012
- Author(s)
  Takashima A
- Journal Title
  
  Front Mol Neurosci
  
  Volume: 5:47 Pages: 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111562
[Journal Article] O-mannosylation is required for the solubilization of heterologously expressed human β-amyloid precursor in Saccharomyces cerevisiae.2009
- Author(s)
  Sekimata A, Sato K, Takashima A, Nakano A
- Journal Title
  
  Genes to Cells 14
  
  Pages: 205-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023032
[Journal Article] Drug development targeting the glycogen synthase kinase-3beta(GSK-3beta)-mediated signal transduction pathway : Role of GSK-3beta in adult brain2009
- Author(s)
  Takashima, A
- Journal Title
  
  Journal of Pharmacological Sciences 109-2
  
  Pages: 174-178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023032
[Journal Article] Amyloid-beta, tau and dementia2009
- Author(s)
  Takashima, A
- Journal Title
  
  Journal of Alzheimer's Disease 17-4
  
  Pages: 729-736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023032
[Journal Article] Amyloid oligomer conformation in a group of natively folded proteins2008
- Author(s)
  Yoshiike Y, Minai R,Matsuo Y, Chen YR, Kimura T, Takashima A.
- Journal Title
  
  PLoSONE 3(9)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023032
[Journal Article] Active c-jun N-terminal kinase induces caspase cleavage of tau and additional phosphorylation by GSK-3 is required for tau aggregation2008
- Author(s)
  Sahara N., Murayama M., Lee B., Park J-M, Lagalwar S, Binder LI.., *Takashima A
- Journal Title
  
  Eur.J.Neurosc 27(11)
  
  Pages: 2897-2906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023032
[Journal Article] GABA_A Receptor-mediated Acceleration of Aging-associated Memory Dcline in APP/PSI Mice and Its Pharmacological Treatment by Picrotoxin2008
- Author(s)
  Yoshiike Y, Kimura T, Yamashita S, Furudate H , Mizoroki T, Murayama M, Takashima A
- Journal Title
  
  PLoSONE 3(8)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023032
[Journal Article] Stress and glucocorticoid footprints in the brain-the path from depression to Alzheimer's disease2008
- Author(s)
  Stotiopoulos I, Cerqueira JJ, Catania C, Takashima A, Sousa N, Almeida OFX
- Journal Title
  
  Neuroscience & Behavioral Reviews 32(6)
  
  Pages: 1161-1173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023032
[Journal Article] Enzymatic characteristics of I213T mutant presenilin-1/γ-secretase in cell models and knock-in mouse brains : FAD-linked mutation impairs γ-site cleavage of APP-CTFβ2008
- Author(s)
  Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A
- Journal Title
  
  J.Biol.Chem 283(24)
  
  Pages: 16488-16496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023032
[Journal Article] GSK-3β is required for memory reconsolidation in adult brain2008
- Author(s)
  Kimura T, Yamashita S, Nakao S, Park J-M, Murayama M, Mizorogi T, Yoshiike Y, Sahara N, Takashima A
- Journal Title
  
  PLoSONE 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023032
[Journal Article] Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.2008
- Author(s)
  Planel E, Krishnamurthy P, Miyasaka T, Li L, Herman M, Kumar A, Bretteville A, Y-figueroa H, H-yu Wai, Whittington R, Davies P, Takashima A, Nixon R, Duff K
- Journal Title
  
  J.Neurosci 28
  
  Pages: 12798-12807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023032
[Journal Article] Hyperphosphorylation of tau is a cause of neuronal degeneration2008
- Author(s)
  Takashima A
- Journal Title
  
  J.Alzheimer's Disease 14(4)
  
  Pages: 371-375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023032
[Journal Article] Pore-forming proteins share structural and functional homology with amyloid oligomers2007
- Author(s)
  Yoshiike Y, Kayed R, Milton SC, Takashima A, Glabe CG
- Journal Title
  
  Neuromolecular Med 9(3)
  
  Pages: 270-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Assembly of two distinct dimers and oligomers from full-length tau2007
- Author(s)
  Sahara N, Maeda S, Murayama M, Suzuki T, Dohmae N, Yen S-H, Takashima A
- Journal Title
  
  Eur. J. Neurosci. 25
  
  Pages: 3020-3029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Electrical stimulation modulates fate determination of differentiating embryonic stem cells.2007
- Author(s)
  Yamada M, Tanemura K, Okada S, Iwanami A, Nakamura M, Mizuno H, Ozawa M, Ohyama-Goto R, Kitamura N, Kawano M, Tan-Takeuchi K, Ohtsuka C, Miyawaki A, Takashima A, Ogawa M, Toyama Y, Okano H, Kondo T
- Journal Title
  
  Stem Cells 25(3)
  
  Pages: 562-570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Novel conformation-sensitive antibodies specific to three-and four-rep eat tau2007
- Author(s)
  Ueno H, Murayama O, Maeda S, Sahara N, Park JM, Murayama M, Sanda A, Iwahashi K, Matsuda M, Takashima A
- Journal Title
  
  Biochem. Biophys. Res. Commun. 358(2)
  
  Pages: 602-607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Neuronal deregulation of tau phosphorylation: Implications for mechanism and treatment of Alzheimer's Disease.2007
- Author(s)
  Takashima A
- Journal Title
  
  Research Progress in Alzheimer's Disease and Dementia
  
  Pages: 61-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] A ganglioside-induced toxic soluble Abeta assembly: Its enhanced for mation from Abeta bearing the Arctic mutation2007
- Author(s)
  Yamamoto N, Matsubara E, Maeda S, Minagawa H, Takashima A, Maruyama W, Michikawa M, Yanagisawa K
- Journal Title
  
  J Biol Chem 282(4)
  
  Pages: 2646-2655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Surface structure of amyloid-beta fibrils contributes to cytotoxicity2007
- Author(s)
  Yoshiike Y, Akagi T, Takashima A
- Journal Title
  
  Biochemistry 46(36)
  
  Pages: 9805-9812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Molecular Chaperone-Mediated Tau Protein Metabolism Counteracts the Formation of Granular Tau Oligomers in Human Brain2007
- Author(s)
  Sahara N, Maeda S, Yoshiike Y, Miroroki T, Yamashita S, Murayama M, Park J.-M, Saito Y, Murayama S, Takashima A
- Journal Title
  
  J. Neurosci. Res 85
  
  Pages: 3098-3108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Granular tau oligomers as intermediates of tau filaments2007
- Author(s)
  Maeda S, Sahara N, Kim H, Saito Y, Akagi T, Miyasaka T, Hashikawa T, Murayama S, Ikai A, Takashima A
- Journal Title
  
  Biochemistry 46(12)
  
  Pages: 3856-3861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Hyperphosphorylated tau in parahippocampal cortex impairs place lear ning in aged mice expressing wild-type human tau2007
- Author(s)
  Kimura T, Yamashita S, Fukuda T, Park J-M, Murayama M, Mizoroki T, Yoshiike Y, Sahara N, and Takashima A
- Journal Title
  
  The EMBO Journal 26(24)
  
  Pages: 5143-5152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Aluminum induces tau aggregation in vitro but not in vivo2007
- Author(s)
  Mizoroki T, Meshitsuka S, Maeda S, Murayama M, Sahara N, Takashima A
- Journal Title
  
  J. Alzheimer's Disease 11(4)
  
  Pages: 419-427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Decrease Aβs secretion in Familial Alzheimer's disease-linked mutant Presenilin 12007
- Author(s)
  Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A
- Journal Title
  
  Neurosci. Res. 57(3)
  
  Pages: 446-453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1).2006
- Author(s)
  Tanemura K, Chui DH, Fukuda T, Murayama M, Park JM, Akagi T, Tatebayashi Y, Miyasaka T, Kimura T, Hashikawa T, Nakano Y, Kudo T, Takeda M, Takashima A.
- Journal Title
  
  J Biol Chem. 281(8)
  
  Pages: 5037-5041
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390329
[Journal Article] c-jun N-terminal kinase yperphosphorylates R406W tau at the PHF-1 site during mitosis.2006
- Author(s)
  Tatebayashi Y, Planel E, Chui DH, Sato S, Miyasaka T, Sahara N, Murayama M, Kikuchi N, Yoshioka K, Rivka R, Takashima A.
- Journal Title
  
  FASEB J. 20(6)
  
  Pages: 762-764
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390329
[Journal Article] タウオパチー動物モデル2005
- Author(s)
  高島明彦
- Journal Title
  
  Cognition and Dementia 4-4
  
  Pages: 57-64
- Data Source
  KAKENHI-PROJECT-17025045
[Journal Article] 神経原線維変化の意義2005
- Author(s)
  高島明彦
- Journal Title
  
  神経研究の進歩 49
  
  Pages: 379-393
- Data Source
  KAKENHI-PROJECT-17025045
[Journal Article] Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice.2005
- Author(s)
  Egashira N, Iwasaki K, Takashima A, Watanabe T, Kawabe H, Matsuda T, Mishima K, Chidori S, Nishimura R, Fujiwara M.
- Journal Title
  
  Brain Res. 1059(1)
  
  Pages: 7-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390329
[Journal Article] Early behavioral abnormalities in a mouse model of FTDP 17.2004
- Author(s)
  Tatebayashi Y, Tominaga M, Takashima A.
- Journal Title
  
  Neurobiol.Aging. 25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390329
[Journal Article] The role of GSK-3β in the formation of neurofibrillary tangles.2004
- Author(s)
  Takashima, A.
- Journal Title
  
  Psychogeriatrics 4
  
  Pages: 17-22
- NAID
  10018089752
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] U-box protein carboxyl terminus of Hsc7-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy.2004
- Author(s)
  Shigetsugu H, Matsumoto M, Kamura T, Murayama M, Chui D-H, Planel E, Takahashi R, Nakayama K-I, Takashima A
- Journal Title
  
  J.Neurochem 91
  
  Pages: 299-307
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation : mechanism and implications for Alzheimer's disease.2004
- Author(s)
  Planel E, Miyasaka T, Launey T, Chui D-H, Tanemura K, Sato S, Murayama O, Ishiguro K, Tatebayashi Y, Takashima A.
- Journal Title
  
  J.Neurosci 24
  
  Pages: 2401-2411
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Amino-and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms : Study of 27 different presenilin 1 mutants2004
- Author(s)
  Hashimoto Y, Tsukamoto E, Niikura T, Yamagishi Y, Ishizaka M, Aiso S, Takashima A, Nishimoto I.
- Journal Title
  
  J.Neurosci.Res. 75(3)
  
  Pages: 417-428
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] The role of GSK-3B in the formation of neurofibrillary tangles.2004
- Author(s)
  Takashima, A.
- Journal Title
  
  Psychogeriatrics 4
  
  Pages: 17-22
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities : implications for Alzheimer's disease.2004
- Author(s)
  Planel E, Miyasaka T, Launey T, Chui DH, Tanemura K, Sato S, Murayama O, Ishiguro K, Tatebayashi Y, Takashima A.
- Journal Title
  
  J Neurosci. 24(10)
  
  Pages: 2401-2411
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390329
[Journal Article] Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro : Implications for the prevention and therapeutics of Alzheimer's disease.2003
- Author(s)
  Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M
- Journal Title
  
  J.Neurochem 87
  
  Pages: 172-181
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Chaperones increase association of tau protein with microtubules.2003
- Author(s)
  Dou F, Netzer WJ, Tanemura K, Li F, Hartl FU, Takashima A, Gouras GK, Greengard P, Xu H.
- Journal Title
  
  Proc Natl Acad Sci U S A. 100(2)
  
  Pages: 721-726
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations.2003
- Author(s)
  Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK.
- Journal Title
  
  Cell. 114(5)
  
  Pages: 635-645
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Specific compositions of amyloid-beta peptides as the determinant of toxic beta-aggregation.2003
- Author(s)
  Yoshiike Y, Chui DH, Akagi T, Tanaka N, Takashima A.
- Journal Title
  
  J Biol Chem. 278(26)
  
  Pages: 23648-23655
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Age-related changes of Alzheimer's disease-associated proteins in cynomolgus monkey brains.2003
- Author(s)
  Kimura N, Tanemura K, Nakamura S, Takashima A, Ono F, Sakakibara I, Ishii Y, Kyuwa S, Yoshikawa Y.
- Journal Title
  
  Biochem Biophys Res Commun. 310(2)
  
  Pages: 303-311
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau2002
- Author(s)
  Tanemura, K., Akagi T., Murayama, M., Hashikawa, T., Tominaga T., Ichikawa, M., Yamaguchi, H., Takashima.A.
- Journal Title
  
  J.Neurosci. 22
  
  Pages: 133-141
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau2002
- Author(s)
  Tatebayashi, Y.Miyasaka, T, Chui, D-H, Akagi, T., Mishima, K., Iwasaki, K., Fujiwara, M., Tanemura, K., Murayama, M., Ishiguro, K., Planel, E., Sato, S., Hashikawa, T., Takashima, A.
- Journal Title
  
  Proc Natl Acad Sci U S A. 99
  
  Pages: 13896-13901
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] The aspartate-257 of presenilin 1 is indispensable for mouse development and production of {beta}-amyloid peptides through {beta}-catenin-independent mechanisms2002
- Author(s)
  Xia X, Wang P, Sun X, Soriano S, Shum WK, Yamaguchi H, Trumbauer ME, Takashima A, Koo EH, Zheng H.
- Journal Title
  
  Proc Natl Acad Sci U S A. 99
  
  Pages: 8760-8765
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C1002002
- Author(s)
  X.Sun, S.Sato, O.Murayama, M.Murayama, J.-M.Park, H.Yamaguchi, Takashima A.
- Journal Title
  
  Neurosci.lett. 15
  
  Pages: 61-64
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro2002
- Author(s)
  Ono K, Hasegawa K, Yoshiike Y, Takashima A, Yamada M, Naiki H.
- Journal Title
  
  J Neurochem. 81(3)
  
  Pages: 434-440
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Production and analysis of human mutant tau(V337M) transgenic mice2002
- Author(s)
  Takashima A
- Journal Title
  
  Mapping the progress of Alzheimer's and Parkinson's disease
  
  Pages: 543-548
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Role of GSK-3B in Alzheimer's disease pathology2002
- Author(s)
  Planel E, Sun, X, Takashima A.
- Journal Title
  
  Drug Dev.Res. 56
  
  Pages: 491-510
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Aberrant tau phosphorylation by GSK-3β and JNK-3 induces oligomeric tau fibrils in COS-7 cells2002
- Author(s)
  Sato, S, Tatebayashi, Y., Akagi, T., Chui, D-H, Murayama, M., Miyasaka, T., Planel, E., Tanemura, K., Sun, X, Hashikawa, T., Yoshioka, K., Ishiguro, K., Takashima, A.
- Journal Title
  
  JBC 277
  
  Pages: 42060-42065
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Age-Related Changes in the Localization of Presenilin-1 in Cynomolgus Monkey Brain2001
- Author(s)
  Kimura, N., Nakamura, S., Honda, T., Takashima, A., Nakayama, H., Ono, F, Sakakibara, I., Doi, K., Kawamura, S., Yoshikawa, Y.
- Journal Title
  
  Brain Res. 922
  
  Pages: 30-41
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau2001
- Author(s)
  Tanemura, K., Akagi T., Murayama, M., Kikuchi, N., Murayama, O., Hashikawa, T., Yoshiike, Y., Park, J-M., Matsuda, K., Nakao, S., Sun, X., Sato, S., Yamaguchi, H., Takashima, A.
- Journal Title
  
  Neurobiol. of Disease 8
  
  Pages: 1036-1045
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Involvement of Cdk5 activator p25 on tau phophorylation in mouse brain2001
- Author(s)
  Takashima A, Murayama M., Yasutake K., Takahashi H, Yokoyama M., Ishiguro
- Journal Title
  
  Neurosci.Lett. 306
  
  Pages: 37-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Presenilin 1 regulates beta-catenin-mediated transcription in a GSK 3beta-independent fashion2001
- Author(s)
  Palacino JJ, Murphy MP, Murayama O, Iwasaki K, Fujiwara M, Takashima A, Golde TE, Wolozin B.
- Journal Title
  
  J Biol Chem 276
  
  Pages: 38563-38569
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] New insights on how metals disrupt amyloid {beta}-aggregation and their effects on amyloid-{beta} cytotoxicity
- Author(s)
  Yoshiike Y, Tanemura K, Murayama O, Akagi T, Murayama M, Sato S, SunX, Tanaka N, Takashima A.
- Journal Title
  
  J.Biol Chem. 276
  
  Pages: 32293-32299
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13210147
[Journal Article] Study of Al on AD pathology-in vitro vs in vivo evidence
- Author(s)
  Takashima A
- Journal Title
  
  J. Alzheimers Disease (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023038
[Journal Article] Role of GSK-3β in adult brain
- Author(s)
  Takashima A
- Journal Title
  
  J. Pharmacol.Sci (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023032
[Presentation] タウ凝集検出プローブの発光率とタウ凝集の相関解析2023
- Author(s)
  内田智也,加藤尚己,服部満,永井健治, 松本弦, 吉村英哲, 高島明彦, 櫻木繁雄, 坂内博子
- Organizer
  新学術領域　シンギュラリティ生物学成果報告シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] タウオリゴマー光誘導モデル細胞を用いた多様なタウ凝集の誘導2023
- Author(s)
  櫻木繁雄 ,坂田佳大,Nathaniel Sebastian H. ,松本弦, 添田義行 ,吉村英哲, 高島明彦,坂内博子
- Organizer
  新学術領域　シンギュラリティ生物学成果報告シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] 光遺伝学に基づくモデル細胞における安定なタウ凝集の生成2023
- Author(s)
  Haryono, Nathaniel、櫻木繁雄、吉村英哲、添田義行、高島明彦、坂内博子
- Organizer
  日本生物物理学会関東支部会
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] 細胞外のタウがGephyrinに与える影響の検討2023
- Author(s)
  榎本実夢、町田彩乃、添田義行、高島明彦、櫻木繁雄、坂内博子
- Organizer
  日本生物物理学会関東支部会
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] ゲノム編集によるタウ標識と生細胞観察によるタウ凝集過程の検討2022
- Author(s)
  片山維央名_櫻木繁雄_添田義行_高島明彦_坂内博子
- Organizer
  第45回分子生物学会年会
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] AMPA受容体クラスターとGABAA受容体クラスターに対する細胞外タウの影響2022
- Author(s)
  町田彩乃,_櫻木繁雄,_添田義行_,高島明彦,_坂内博子
- Organizer
  Neuro2022神経科学学会
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] AMPA受容体とGABAA受容体に対する細胞内外のタウの影響2022
- Author(s)
  町田彩乃_,櫻木繁雄,_添田義行,_高島明彦,_坂内博子
- Organizer
  第45回分子生物学会年会
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] タウオリゴマーの人為的誘導の可能性2021
- Author(s)
  坂内博子、亀崎貴也、吉村英哲、添田義行、高島明彦
- Organizer
  新学術領域「シンギュラリティ生物学」第４回領域会議
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] AMPA受容体, GABAA受容体に対する細胞外タウタンパク質の影響2021
- Author(s)
  町田彩乃、櫻木繁雄、添田義行、高島明彦、坂内博子
- Organizer
  新学術領域「シンギュラリティ生物学」第４回領域会議
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] 光遺伝学的手法を用いたタウ凝集体形成2021
- Author(s)
  添田義行、吉村英哲、坂内博子、高島明彦
- Organizer
  新学術領域「シンギュラリティ生物学」第４回領域会議
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] 認知症最初期に起こる嗅内野機能低下を検出する VR-ゴーグルの開発2020
- Author(s)
  添田義行、笠井淳史、源田公平、甲斐英隆、高島明彦
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] グルタミン酸刺激に応じた樹状突起GSK3βの活性化とタウの過剰リン酸化2020
- Author(s)
  田中融、大橋祥世、高島明彦、小林俊亮
- Organizer
  第43回日本分子生物学会
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] 超高齢社会を考えるⅣ　＜超高齢社会を支える技術と倫理＞2020
- Author(s)
  高島明彦
- Organizer
  第８回学習院大学ブランディング・シンポジウム（第27回生命科学シンポジウム）
- Invited
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] １分子解析による生理的タウの新機能の発見2019
- Author(s)
  坂内博子、金谷美沙、高島明彦
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] カテコール骨格を持つ低分子化合物のタウ凝集阻害作用2019
- Author(s)
  添田義行　石村結麻　斉藤万梨乃　高島明彦
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] What singularity biology can do for understanding Alzheimer’s disease2019
- Author(s)
  Hiroko Bannai, Michio Hiroshima, Yoshiyuki Soeda, Akihiko Takashima
- Organizer
  第57回生物物理学会年会シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] 植物由来抽出物を使ったタウ凝集阻害剤のスクリーニング2019
- Author(s)
  阿部将志, 添田義行, 楊　金緯, 立﨑　仁, 高島明彦
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] Methylene blue inhibits formation of tau fibrils but not granular tau oligomers（ポスター）2018
- Author(s)
  Saito M, Soeda Y, Maeda S, Takashima A
- Organizer
  Society for Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] In vitro disease modeling of the FTDP-17 TAU R406W mutation using patient-derived iPSCs.2018
- Author(s)
  Nakamura M, Watanabe H, Shiozawa S, Maeda S, Hisanaga SI, Sahara N, Kimura T, Miyasaka T, Takashima A, Ikeuchi T, Okano H
- Organizer
  Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] Methylene blue inhibits formation of tau fibrils but not granular tau oligomers2018
- Author(s)
  M. SAITO, Y. SOEDA, S. MAEDA, A. TAKASHIMA
- Organizer
  SfN 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H07087
[Presentation] Physiological role of dendritic tau protein on AMPA receptor dynamics2018
- Author(s)
  Kanatani M, Bannai H, Soeda Y, Maeda S, Takashima A
- Organizer
  Society for Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] 認知症治療に向けたタウ凝集剤の開発2018
- Author(s)
  高島明彦
- Organizer
  創薬薬理フォーラム第26回シンポジウム
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] AMPA/NMDA stimulation causes somatodendritic localization of hyperphosphorylated tau protein2018
- Author(s)
  Takashima A
- Organizer
  EuroTau2018
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] In vitro disease modeling of the FTDP-17 TAU R406W mutation using patient-derived iPSCs2018
- Author(s)
  M. NAKAMURA, H. WATANABE, S. SHIOZAWA, S. MAEDA, S.-I. HISANAGA3, N. SAHARA, T. KIMURA, T. MIYASAKA, A. TAKASHIMA, T. IKEUCHI, H. OKANO
- Organizer
  SfN 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H07087
[Presentation] Physiological role of dendritic tau protein on AMPA receptor dynamics2018
- Author(s)
  M. KANATANI, H. BANNAI, Y. SOEDA, S. MAEDA, A. TAKASHIMA
- Organizer
  SfN 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H07087
[Presentation] Approach to role of physiological Tau protein by single molecule analysis of membrane molecule dynamics2018
- Author(s)
  Hiroko Bannai, Misa Kanatani, Sumihiro Maeda, Matsumi Hirose, Akihiko Takashima, Katsuhiko Mikoshiba
- Organizer
  12th International Symposium on NanoMedicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] タウタンパク質老化機構2017
- Author(s)
  高島明彦
- Organizer
  第30回日本老年学会総会シンポジウム
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] 認知症治療最前線2017
- Author(s)
  高島明彦
- Organizer
  学際生命科学東京コンソーシアム　第11回市民講演会
- Place of Presentation
  東京医科歯科大学
- Invited
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] タンパク質の生理機能と認知症における役割2017
- Author(s)
  高島明彦
- Organizer
  CnBio(分子生物学会）ワークショップ
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] Local somatodendrititc translation of tau protein triggered by AMPA and NMDA receptor stimulation2017
- Author(s)
  高島明彦
- Organizer
  Society for Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] Accumulation of phosphorylated tau in neurons in FUS-silenced mice2016
- Author(s)
  Ishigaki S, Fujioka Y, Honda D, Yokoi S, Endo K., Okado H, Watanabe H, Katsuno M, Takashima A., Sobue G.
- Organizer
  The 46th Society for Neuroscience annual meeting
- Place of Presentation
  San Diego, CA
- Year and Date
  2016-11-12
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] タウのタンパク質老化と毒性機序2016
- Author(s)
  高島明彦
- Organizer
  次世代脳プロジェクト　冬のシンポジウム
- Place of Presentation
  一橋大学
- Invited
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] 認知症治療最前線2016
- Author(s)
  高島明彦
- Organizer
  第88回学習院大学技術交流会
- Place of Presentation
  学習院大学
- Invited
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] Mechanism of neurodegeneration and therapy for Alzheimer's disease2016
- Author(s)
  高島明彦
- Organizer
  AD International Conference in Hefei
- Place of Presentation
  University of Science and Technology of China
- Invited
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] Mechanism of Neurodegeneration through Tau and Therapy for AD.2016
- Author(s)
  Takashima A
- Organizer
  The 1st International Gachon Neuroscience Symposium,
- Place of Presentation
  Korea
- Year and Date
  2016-02-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] タウとアルツハイマー病2016
- Author(s)
  高島明彦
- Organizer
  埼玉医科大学　卒後教育委員会　後援　学術集会
- Place of Presentation
  埼玉医科大学
- Invited
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] タウイメージングに期待されること2015
- Author(s)
  高島明彦
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  青森
- Year and Date
  2015-10-02
- Invited
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] Distribution of endogenous and exogenous tau in the mouse brain2015
- Author(s)
  Atsuko Kubo, Hiroaki Misonou, Makoto Matsuyama, Akihiko Takashima, Yasuo Ihara, Tomohiro Miyasaka
- Organizer
  The 12th International Conference on Alzheimer's and Parkinson's Diseases
- Place of Presentation
  Nice, France
- Year and Date
  2015-03-21
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] Therapy against toxic tau aggregation in AD2015
- Author(s)
  高島明彦
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟
- Year and Date
  2015-05-21
- Invited
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] Aging and Tau2015
- Author(s)
  Takashima A.
- Organizer
  Asian Aging Core for Longevity (AACL) 10 years and Beyond Japan-Korea Joint Seminars
- Place of Presentation
  Osaka, Japan.
- Year and Date
  2015-03-12
- Invited
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] アルツハイマー病治療に向けて：タウ研究からのアプローチ2015
- Author(s)
  高島明彦
- Organizer
  第10回青森神経科学談話会
- Place of Presentation
  弘前
- Year and Date
  2015-07-28
- Invited
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] Strategy of tau related therapy.2015
- Author(s)
  高島明彦
- Organizer
  第55回日本核医学会学術総会　シンポジウム
- Place of Presentation
  東京
- Year and Date
  2015-11-06
- Invited
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] タウの基礎研究から試みる認知症治療薬開発2015
- Author(s)
  高島明彦
- Organizer
  シンポジウム「アルツハイマー病先制治療薬の創出」
- Place of Presentation
  名古屋市
- Year and Date
  2015-01-17
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] Granular tau oligomer as toxic tau aggregation form in AD.2014
- Author(s)
  Takashima A.
- Organizer
  Alzheimer’s Association International Conference 2014
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2014-07-14
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] タウ分子からアプローチするアルツハイマー病2014
- Author(s)
  高島明彦
- Organizer
  公益財団法人新世代研究所　バイオ単分子研究会
- Place of Presentation
  静岡県伊東市
- Year and Date
  2014-07-26
- Invited
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] Tau /tau interaction through Cys residue form a toxic tau aggregate.2014
- Author(s)
  Takashima A.
- Organizer
  7th Asian Aging Core for Longevity (AACL) conference in Jeju
- Place of Presentation
  Jeju, Korea.
- Year and Date
  2014-09-22
- Invited
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] タウタンパク質老化と毒性機序2014
- Author(s)
  高島明彦
- Organizer
  脳タンパク質老化と認知症制御キックオフシンポジウム
- Place of Presentation
  東京都千代田区
- Year and Date
  2014-10-08
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] tau-Tg マウス脳における内在性および外来性タウの神経細胞内局在2014
- Author(s)
  久保厚子、御園生裕明、松山誠、高島明彦、井原康夫、宮坂知宏
- Organizer
  第33回日本認知症学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2014-12-01
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] マウス脳における内在性および外来性 tau の局在2014
- Author(s)
  久保厚子、御園生裕明、松山誠、高島明彦、井原康夫、宮坂知宏
- Organizer
  第37回日本神経科学大会 Neuroscience 2014
- Place of Presentation
  横浜市
- Year and Date
  2014-09-12
- Data Source
  KAKENHI-PLANNED-26117004
[Presentation] Granular tau oligomer: toxic tau aggregation2013
- Author(s)
  Takashima A
- Organizer
  Cantoblanco Workshops on Biology : Is tau a prion-like protein? Implications for physiology and pathology,
- Place of Presentation
  Madrid, SPAIN
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] タウを標的とした認知症治療について2013
- Author(s)
  高島明彦
- Organizer
  第3回アルツハイマー病診断・治療薬創出に向けた革新的探索系構築に関する研究会,
- Place of Presentation
  愛知
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] タウ凝集阻害による認知症治療の可能性2012
- Author(s)
  高島明彦
- Organizer
  第34回日本生物学的精神医学会,
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] タウ凝集阻害による認知症治療の可能性2012
- Author(s)
  高島明彦
- Organizer
  日本神経治療学会総会,
- Place of Presentation
  北九州
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] Tau,Microtubeles, in AD2012
- Author(s)
  Takashima A
- Organizer
  Asian Aging2012: Korea-Japan Joint Conference on Aging, Metabolism and Neurobiology,
- Place of Presentation
  the republic of Korea
- Year and Date
  2012-11-23
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] Intermediate of Tau Fibril is Involved in Neuronal Loss2012
- Author(s)
  Takashima A
- Organizer
  Alzheimaer’s Association International Conference ,
- Place of Presentation
  Canada
- Year and Date
  2012-07-14
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] タウオパチーからみたアルツハイマー病2012
- Author(s)
  高島明彦
- Organizer
  第19回九州老年期認知症研究会,
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] 抗タウ薬の開発：現状と展望2012
- Author(s)
  高島明彦
- Organizer
  アルツハイマー病の最先端研究シンポジュウムin熊本
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] タウとシナプス可塑性について2012
- Author(s)
  高島明彦
- Organizer
  第31回日本認知症学会学術集会,
- Place of Presentation
  つくば
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] Neurofivrillary Tangle Formation Process and Neurodegenerative system and Onset of dementia mechanism2012
- Author(s)
  Takashima A
- Organizer
  Aging and Neurodegenerative Diseases,
- Place of Presentation
  The Republic of Korea
- Year and Date
  2012-04-26
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] 抗タウ薬の開発：現状と展望2012
- Author(s)
  高島明彦
- Organizer
  ゲノム創薬フォーラム第15回シンポジウム
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] Granular tau oligomer:Intermediate of tau fibril is involved in neuronal loss2012
- Author(s)
  Takashima A
- Organizer
  11th Biennial Meeting of the Asian Pacific Society for Neurochemistry,
- Place of Presentation
  Kobe
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] Tau and GSK-3b are required for maintaining brain function at old age and NFT formation in AD2012
- Author(s)
  Takashima A
- Organizer
  4th Brain Plasticity Symposium,
- Place of Presentation
  Australia
- Year and Date
  2012-09-03
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] Involvement of different tau aggregations on synapse loss and neuron loss in AD2009
- Author(s)
  Takashima, A
- Organizer
  1^<st> International Conference on Translational Research in Alzheimer's Disease
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-20023032
[Presentation] Distinct tau aggregation form involves in synapse loss and neuron loss2009
- Author(s)
  Takashima, A
- Organizer
  International Conference on Alzheimer's Disease
- Place of Presentation
  Vienna, Austria
- Year and Date
  2009-07-14
- Data Source
  KAKENHI-PROJECT-20023032
[Presentation] タウ研究から見たアルツハイマー病における神経変性機構2009
- Author(s)
  Takashima, A
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-20023032
[Presentation] タウ凝集阻害剤の創出
- Author(s)
  高島明彦
- Organizer
  中部橋渡し研究支援シンポジウム
- Place of Presentation
  名古屋市
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] 脳科学におけるアルツハイマー病研究
- Author(s)
  高島明彦
- Organizer
  同志社大学セミナー
- Place of Presentation
  京都府木津川市
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] Tau protein as key converter of normal brain aging to dementia
- Author(s)
  Takashima A
- Organizer
  IBRO-sponsored International Symposium : Current Aspects in Pathophysiology of Alzheimer’s disease,
- Place of Presentation
  Braga, PORTUGAL
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] タウを標的とした認知症治療の現状と展望
- Author(s)
  高島明彦
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京都千代田区
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] タウ凝集を標的にしたアルツハイマー病治療薬開発について
- Author(s)
  高島明彦
- Organizer
  精神疾患の薬物治療の最前線研究会
- Place of Presentation
  福岡市
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] Tau aggregation and neuronal degeneration
- Author(s)
  Takashima A.
- Organizer
  第11回世界生物学的精神医学会国際会議
- Place of Presentation
  京都市
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] Mechanism of aging brain and Alzheimer’s disease
- Author(s)
  Takashima A.
- Organizer
  2nd Brain Diseases & Molecular Machines Conference
- Place of Presentation
  東京都港区
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] タウからみたアルツハイマー病発症機構と創薬
- Author(s)
  高島明彦
- Organizer
  広島大学セミナー
- Place of Presentation
  広島市
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[Presentation] 脳の老化と認知症
- Author(s)
  高島明彦
- Organizer
  学習院大学生命科学シンポジウム　生命の秘密を解く鍵をもとめて
- Place of Presentation
  東京都豊島区
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111562
[]

1. SAHARA Naruhiko (40261185)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. KOIKE Tatsuro (80128131)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. Maeda Sumihiro (70443025)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. SUMIOKA Akio (00431320)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TATEBAYASHI Yositaka (80342814)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
6. 孫小燕 (50312278)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 木村哲也 (00415142)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 福田哲也 (70316511)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 吉池裕二 (90415331)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
10. 宮坂知宏 (90342857)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
11. GOTO Asako (90455460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MURAYAMA Ohoshi (20301781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ISHIZUKA Koko (80373265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ITOKAWA Masanari (40332324)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TANAKA Shuitsu (90202431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Bannai Hiroko (40332340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
17. 村上明子 (50321823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 久永眞市 (20181092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 石垣診祐 (40378170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 池川雅哉 (60381943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 種村健太郎 (20332322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
22. 佐藤慎二 (10322702)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 廣島通夫 (20392087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 松本弦 (50415303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
25. 松田恵子 (40383765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 林賢 (80534528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 神崎晶 (50286556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. Soeda Yoshiyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
29. Misonou Hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
30. Taguchi Akiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 朴正美

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 菊池尚美

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 村山美由紀

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 崔得華

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. エマヌエルプラネル

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. CHUI De-Hua

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
37. PLANEL Emmanuel

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
38. 催徳華

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. プラネルエマヌエル

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. YOSHIKAWA Keisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. SHIOZAWA Seiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. OHTA Etsuro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. YOSHIDA Mari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 淡路健雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 丸山敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
46. 柳下聡介

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
47. 道川誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 須原哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
49. 樋口真人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
50. 前田純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. 山下典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 木村龍一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 飯島香奈絵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 近藤恭光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
55. 岡田洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 赤池孝章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
57. 内原俊記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takashima Akihiko 高島 明彦

TAKASHIMA Akihiko 高島 明彦

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of tau protein aging and neurodegenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

シナプス活動を介した神経原線維変化形成機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経原線維変化形成機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経原線維変化形成機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経原線維変化形成機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of NFT formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経原線維変化生成機序Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

老化に伴う脳神経細胞のテロメア動態Principal Investigator

Principal Investigator

Project Period (FY)

Takashima Akihiko 高島明彦

TAKASHIMA Akihiko 高島明彦