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Kobayashi Masao  小林 正夫

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… Alternative Names

KOBAYASHI Masao  小林 正夫

小林 正夫  コバヤシ マサオ

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Researcher Number 00162016
Other IDs
Affiliation (Current) 2022: 広島大学, 医系科学研究科(医), 名誉教授
Affiliation (based on the past Project Information) *help 2019 – 2020: 広島大学, 医系科学研究科(医), 名誉教授
2018: 広島大学, 医歯薬保健学研究科(医), 名誉教授
2017 – 2018: 広島大学, 医歯薬保健学研究科(医), 教授
2015: 広島大学, 医歯薬保健学研究院, 教授
2014 – 2015: 広島大学, 医歯薬保健学研究院(医), 教授 … More
2013: 広島大学, 医歯薬保健学研究院, 教授
2012: 広島大学, その他の研究科, 教授
2012: 広島大学, 大学院・医歯薬保健学研究院, 教授
2010 – 2011: 広島大学, 大学院・医歯薬学総合研究科, 教授
2008: Hiroshima University, 大学院医歯薬学総合研究科, 教授
2007 – 2008: Hiroshima University, 大学院・医歯薬学総合研究科, 教授
2003 – 2005: 広島大学, 大学院・医歯薬学総合研究科, 教授
2001 – 2002: 広島大学, 大学院・教育学研究科, 教授
2001: 広島大学, 教育学研究科, 教授
1998 – 2000: FACULTY OF EDUCATION,CHILD HEALTH,HIROSHIMA UNIVERSITY PROFESSOR, 教育学部, 教授
1997: 広島大学, 教育学部, 助教授
1993: 広島大学, 医学部, 助手
1989 – 1990: 広島大学, 医学部, 助手
1986: 広島大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Pediatrics / Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Except Principal Investigator
Pediatrics / 環境影響評価(含放射線生物学) / 実験系心理学 / Pediatrics / Tumor biology and related fields
Keywords
Principal Investigator
先天性好中球減少症 / 免疫不全マウス / 異種間移植 / iPS細胞 / 遺伝子編集 / 造血細胞 / 造血因子 / 異種移植 / Hematopoietic progenitors / Hematopoietic factors … More / Xenogeneic transplantation / Hematopoiesis / FACS / Mesenchymal Stem Cell / Bone Marrow / ABC-G2 / 造血幹細胞 / 細胞表面抗原 / 細胞接着因子 / 細胞接着蛋白 / 生着促進 / 小児血液学 / ヒト化マウス / 食細胞異常症 / 人工ヌクレアーゼ / 遺伝子修復 / TALEN / STAT1 / 単球機能 / 破骨細胞 / 食細胞 / 原発性免疫不全症 / 細胞純化 / 造血前駆細胞 / Cell sorting / Severe congenital neutropenia / 共培養 / 骨髄間質細胞 / Coculture / Stromal cell / Congenital Neutropenia / 骨髄顆粒球系細胞の増殖・分化 / 遺伝子発現 / 好中球エラスターゼ遺伝子 / 一次顆粒酵素 / 顆粒蛋白 / 骨髄顆粒球系前駆細胞 / G-CSF受容体 / Sever congenital neutropenia / Myeloid proliferation / Gene expression / Neutrophil elastase / Primary granules / Mesenchymal stem cell / Bone marrow / ABCG2 / 好中球減少症 / 好中球エラスターゼ / アポトーシス / 疾患特異的iPS細胞 / SRP54 / 好中球アポトーシス … More
Except Principal Investigator
zinc finger / 異種間移植 / NOD / HL-60 / LTB4 / fMLP / LTB4レセプタ- / fMLPレセプタ- / 細胞内Ca^<2+> / C7欠損症 / 急性リンパ性白血病 / 残存白血病細胞 / PCR法 / CDR III領域 / tal-1遺伝子 / 癌遺伝子産物 / Ras-p21 / 小児悪性腫瘍 / アポトーシス / 電離放射線 / 転写因子 / ストレス応答 / apoptosis / ionizing radiation / transcription factor / 移植片生着促進細胞 / SCIDマウス / 好中球減少症 / Facilitating cell / Xenograft / SCID mouse / Neutropenia / 乳幼児 / 認知・情動的クオリア / 発達神経心理学 / 近赤外線分校法 / 脳機能イメージング / 近赤外線分光法 / 近赤外線分光法(NIRS) / 脳機能の左右差 / 母子相互作用 / 母乳・人工乳 / 近赤外分光脳機能イメージング / 顔面サーモグラフ / 視覚的対象認知処理 / 近赤外線脳活動イメージング / サーモグラフィー / Infant / Cognitive and Emotional Qualia / Developmental Neuropsycholgy / Near-Infrared spectroscopy (NIBS) / Brain Functional Imaging / 骨髄腔内輸注 / 造血幹細胞移植 / NOD-SCIDマウス / 好中球エラスターゼ / Xenotransplantation / Intra-bone marrow injection / Stem cell transplantation / NOD-SCID mouse / 小児血液学 / iPS細胞 / 白血病発症機序 / 先天性骨髄不全症候群 / 小児がん / 重症先天性好中球減少症 / 白血病 / 遺伝性腫瘍症候群 / cancer predisposition Less
  • Research Projects

    (18 results)
  • Research Products

    (155 results)
  • Co-Researchers

    (59 People)
  •  Gene editing for the study of severe congenital neutropeniaPrincipal Investigator

    • Principal Investigator
      Kobayashi Masao
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Hiroshima University
  •  Investigation of pathogenesis of leukemia in congenital bone marrow failure syndrome using human iPS cells

    • Principal Investigator
      Mochizuki Shinji
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Tumor biology and related fields
    • Research Institution
      Hiroshima University
  •  Analysis of abnormal STAT1 disorders using disease-specific iPS cells.Principal Investigator

    • Principal Investigator
      Kobayashi Masao
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Pediatrics
    • Research Institution
      Hiroshima University
  •  Gene editing of iPS cells derived from patients with congenital phagocytic disordersPrincipal Investigator

    • Principal Investigator
      Kobayashi Masao
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Hiroshima University
  •  Application of humanized mice to analyses and therapeutics of phagocytic disordersPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Masao
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Hiroshima University
  •  The cell-surface modification enhances the engraftment of human CD34-positive cells into immunodeficient micePrincipal Investigator

    • Principal Investigator
      KOBAYASHI Masao
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Hiroshima University
  •  Basic research for the establishment of the intra-bone marrow stem cell transplantation

    • Principal Investigator
      SATO Takashi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Purification, expansion, and reconstitution of mesodermal stemcells from human bone marrowPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Masao
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Neupsycological study for the development of cognitive and emotional qualia in infants.

    • Principal Investigator
      TOSHIMA Tamotsu
    • Project Period (FY)
      2002 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      実験系心理学
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  GENE EXPRESSIONS DURING PROLIFERATION AND DIFFERENTIATION OF MYELOID CELIS IN SEVERE CONCENITAL NEUTROPENIAPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Masao
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      HIROSHIMA UNICERSITY
  •  Identification of Human facilitating cells

    • Principal Investigator
      SATO Takashi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  EXPANSION OF HUMAN BONE MARROW CELLS CAPABLE OF REPOPULATING IN MICE BY COCULTURE WITH BONE MARROW STROMAL CELLSPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Masao
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  A study for a transcription factor gene regulating radiation sensitivity

    • Principal Investigator
      KATOH Osamu
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  CHARACTERIZATION OF PURIFIED HUMAN HEMATOPOIETIC PROGENITOR CELLS OF BONE MARROW AND THEIR RECONSTITUTING ABILITY IN GENOGENEIC TRANSPLANTATIONPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Masao
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  小児急性リンパ性白血病の微少残存白血病の検出に関する研究

    • Principal Investigator
      上田 一博
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Hiroshima University
  •  補体第7成分(C7)の分子遺伝学的研究

    • Principal Investigator
      上田 一博
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Hiroshima University
  •  顆粒球の機能的分化とロイコトリエン・リセプタ-、走代因子リセプタ-に関する研究

    • Principal Investigator
      UEDA Kazuhiro
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Hiroshima University
  •  小児悪性腫瘍細胞における癌遺伝子の形質発現に関する研究

    • Principal Investigator
      田中 丈夫
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Hiroshima University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005 2004 2003 2002 Other

All Journal Article Presentation Book

  • [Book] 新臨床内科学2020

    • Author(s)
      小林正夫(一部執筆):先天性好中球減少症,周期性好中球減少症
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-18K07847
  • [Book] 好中球減少症2011

    • Author(s)
      小林正夫
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Book] 今日の小児治療指針「好中球減少症」2011

    • Author(s)
      小林正夫
    • Total Pages
      2
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Book] Annual Review 20102010

    • Author(s)
      岡田賢,小林正夫
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Book] 骨髄不全症候群とリボゾームの異常2010

    • Author(s)
      岡田賢, 小林正夫
    • Total Pages
      9
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Book] 先天性好中球減少症の成因(Annual Review)2008

    • Author(s)
      小林正夫, 岡田賢, 三木瑞香
    • Publisher
      中外医学社 東京
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Book] Annual Review血液20082008

    • Author(s)
      小林正夫, 岡田 賢, 三木瑞香
    • Publisher
      中外医学社,東京
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Book] Annual Review 血液 20082008

    • Author(s)
      小林正夫, 岡田賢, 三木瑞香
    • Publisher
      中外医学社, 東京
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Book] 血小板及び顆粒球抗原・抗体の臨床と技術2005

    • Author(s)
      佐藤 貴, 小林正夫, 平岡朝子
    • Total Pages
      200
    • Publisher
      日本血小板・顆粒球型ワークショップ
    • Data Source
      KAKENHI-PROJECT-16591031
  • [Book] Annual Review 血液 20052005

    • Author(s)
      川口浩史, 中村和洋, 小林正夫
    • Data Source
      KAKENHI-PROJECT-15591111
  • [Journal Article] Bone marrow transplantation from a human leukocyte antigen-mismatched unrelated donor in a case with C1q deficiency associated with refractory systemic lupus erythematosus2021

    • Author(s)
      Matsumura Risa、Mochizuki Shinji、Maruyama Natsuki、Morishita Yusuke、Kawaguchi Hiroshi、Okada Satoshi、Tsumura Miyuki、Kaji Shunsaku、Shimizu Junya、Shimada Akira、Kobayashi Masao
    • Journal Title

      International Journal of Hematology

      Volume: 113 Pages: 302-307

    • DOI

      10.1007/s12185-020-03004-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-18K07847, KAKENHI-PROJECT-18KK0228
  • [Journal Article] IRAK4 Deficiency Presenting with Anti-NMDAR Encephalitis and HHV6 Reactivation2021

    • Author(s)
      Nishimura S, Kobayashi Y, Ohnishi H, Moriya K, Tsumura M, Sakata S, Mizoguchi Y, Takada H, Kato Z, Sancho-Shimizu V, Picard C, Irani SR, Ohara O, Casanova JL, Puel A, Ishikawa N, Okada S, Kobayashi M.
    • Journal Title

      Journal of Clinical Immunology

      Volume: 41 Pages: 125-135

    • DOI

      10.1007/s10875-020-00885-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08249, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-19H03613, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-18K07847, KAKENHI-PROJECT-18K15716, KAKENHI-PROJECT-18KK0228
  • [Journal Article] Downregulation of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) in a co-culture system with human stimulated X-linked CGD neutrophils2020

    • Author(s)
      Nakamura-Utsunomiya Akari、Tsumura Miyuki、Okada Satoshi、Kawaguchi Hiroshi、Kobayashi Masao
    • Journal Title

      PLOS ONE

      Volume: 15

    • DOI

      10.1371/journal.pone.0230665

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10112, KAKENHI-PROJECT-17K19600, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-18KK0228
  • [Journal Article] Human STAT1 Gain-of-Function Heterozygous Mutations: Chronic Mucocutaneous Candidiasis and Type I Interferonopathy2020

    • Author(s)
      Okada Satoshi、Asano Takaki、Moriya Kunihiko、Boisson-Dupuis Stephanie、Kobayashi Masao、Casanova Jean-Laurent、Puel Anne
    • Journal Title

      Journal of Clinical Immunology

      Volume: 40 Pages: 1065-1081

    • DOI

      10.1007/s10875-020-00847-x

    • NAID

      120007168960

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-18K07847, KAKENHI-PROJECT-18KK0228
  • [Journal Article] Human gain-of-function STAT1 mutation disturbs IL-18 immunity in mice2020

    • Author(s)
      Tamaura M, Satoh-Takayama N, Tsumura M, Sasaki T, Goda S, Kageyama T, Hayakawa S, Kimura S, Asano T, Nakayama M, Koseki H, Ohara O, Okada S, Ohno H, Kobayashi M
    • Journal Title

      International Immunology

      Volume: 32 Pages: 259-272

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07847
  • [Journal Article] Human gain-of-function STAT1 mutation disturbs IL-17 immunity in mice2020

    • Author(s)
      Tamaura Moe、Satoh-Takayama Naoko、Tsumura Miyuki、Sasaki Takaharu、Goda Satoshi、Kageyama Tomoko、Hayakawa Seiichi、Kimura Shunsuke、Asano Takaki、Nakayama Manabu、Koseki Haruhiko、Ohara Osamu、Okada Satoshi、Ohno Hiroshi、Kobayashi Masao
    • Journal Title

      International Immunology

      Volume: - Pages: 259-272

    • DOI

      10.1093/intimm/dxz079

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18KK0228, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-17K10112, KAKENHI-PROJECT-20K08158, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-18K07189, KAKENHI-PROJECT-18K07847
  • [Journal Article] Impact of graft-versus-host disease on the clinical outcome of allogeneic hematopoietic stem cell transplantation for non-malignant diseases.2020

    • Author(s)
      Umeda K, Imai K, Yanagimachi M, Yabe H, Kobayashi M, Takahashi Y, Kajiwara M, Yoshida N, Cho Y, Inoue M, Hashii Y, Atsuta Y, Morio T
    • Journal Title

      International Journal of Hematology

      Volume: - Pages: 869-876

    • DOI

      10.1007/s12185-020-02839-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-17H04233, KAKENHI-PROJECT-17K19600, KAKENHI-PROJECT-18H02690
  • [Journal Article] Hematopoietic Cell Transplantation for Chronic Granulomatous Disease in Japan2020

    • Author(s)
      Yanagimachi M, Kato K, Iguchi A, Sasaki K, Kiyotani C, Koh K, Koike T, Sano H, Shigemura T, Muramatsu H, Okada K, Inoue M, Tabuchi K, Nishimura T, Mizukami T, Nunoi H, Imai K, Kobayashi M, Morio T.
    • Journal Title

      Frontiers in Immunology

      Volume: 11 Pages: 1617-1617

    • DOI

      10.3389/fimmu.2020.01617

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-18K07847
  • [Journal Article] Downregulation of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) in a co-culture system with human stimulated X-linked CGD neutrophils.2020

    • Author(s)
      akamura-Utsunomiya A, Tsumura M, Okada S, Kawaguchi H, Kobayashi M
    • Journal Title

      PLoS one

      Volume: in press

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07847
  • [Journal Article] Human granulocytes undergo cell death via autophagy2018

    • Author(s)
      Kajiume T, Kobayashi M
    • Journal Title

      Cell Death Discov

      Volume: 4 Pages: 111-116

    • DOI

      10.1038/s41420-018-0131-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07847
  • [Journal Article] Monogeneic mutations differentially affect the quality of T follicular helper cells in pateints with human primary immunodeficiencies.2016

    • Author(s)
      Ma CS, Wong N, Tangye SG, et al.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 136 Pages: 993-1006

    • DOI

      10.1016/j.jaci.2015.05.036

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15396, KAKENHI-PROJECT-15K15392, KAKENHI-PROJECT-26670501, KAKENHI-PROJECT-25293231, KAKENHI-PROJECT-25293232, KAKENHI-PROJECT-26293250, KAKENHI-PROJECT-25713039
  • [Journal Article] Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations2015

    • Author(s)
      Okada S, Markle JG, Deenick EK, Federico Mele F, Averbuch D, Kobayashi M, Abel L, Cooper AM, Notarangelo LD, Boisson-Dupuis S, Puel A, Sallusto F, Bustamante J, Tangye SG, Casanova JL
    • Journal Title

      Science

      Volume: 349 Pages: 606-13

    • DOI

      10.1126/science.aaa4282

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670501, KAKENHI-PROJECT-25293231, KAKENHI-PROJECT-25713039
  • [Journal Article] Paroxysmal nocturnal hemoglobinuria and telomere length predicts response to immunosuppressive therapy in pediatric aplastic anemia.2015

    • Author(s)
      Narita A, Muramatsu H, Sekiya Y, Okuno Y, Sakaguchi H, Nishio N, Yoshida N, Wang X, Xu Y, Kawashima N, Doisaki S, Hama A, Takahashi Y, Kudo K, Moritake H, Kobayashi M, Kobayashi R, Ito E, Yabe H, Ohga S, Ohara A, Kojima S; Japan Childhood Aplastic Anemia Study Group.
    • Journal Title

      Haematologica

      Volume: 100 Pages: 1546-1552

    • DOI

      10.3324/haematol.2015.132530

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09647, KAKENHI-PROJECT-26670501, KAKENHI-PROJECT-25293231
  • [Journal Article] STAT3 is a critical cell intrinsic regulator of human unconventional T cell numbers and function.2015

    • Author(s)
      Wilson RP, Ives ML, Rao G, Lau A, Payne K, Kobayashi M, Holland SM, Casanova JL, Uzel G, Ma CS, Tangye SG, Deenick EK
    • Journal Title

      Journal of Experimental Medicine,

      Volume: 212 Pages: 855-864

    • DOI

      10.1084/jem.20141992

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670501, KAKENHI-PROJECT-25293231
  • [Journal Article] he International Immune Tolerance Induction Study and its follow-up study on Japanese hemophilia A patients with inhibitors2015

    • Author(s)
      Yoshioka A, Ishii E, Ueno T, Usami I, Kobayashi M, Kobayashi R, Sotomatsu M, Shirahata A, Suzuki T, Taki M, Ishida Y, Matsushita T, Shima M, Nogami K, Sakai M, Kigasawa H, Fukutake K
    • Journal Title

      Int J Hematol

      Volume: 101(4) Pages: 362-368

    • DOI

      10.1007/s12185-015-1734-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25461445, KAKENHI-PROJECT-26670501
  • [Journal Article] Mosaicism of an ELANE Mutation in an Asymptomatic Mother in a Familial Case of Cyclic Neutropenia.2015

    • Author(s)
      Hirata O, Okada S, Ttsumura M, Karakawa S, Matsumura I, Kimura Y, Mihara T, Yasunaga S, Takihara Y, Ohara O, Kobayashi M
    • Journal Title

      J. Clin. Immunol.

      Volume: 2015 Pages: 1-5

    • DOI

      10.1007/s10875-015-0165-1

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293231, KAKENHI-PROJECT-15K09461, KAKENHI-PROJECT-26501004, KAKENHI-PROJECT-15K21189, KAKENHI-PROJECT-26670501, KAKENHI-PROJECT-25713039
  • [Journal Article] A 2-year-old Japanese girl with TNF receptor-associated periodic syndrome: A case report of the youngest diagnosed proband in Japan.2014

    • Author(s)
      Yasumura J, Wago M, Okada S, Nishikomori R, Takei S, Kobayashi M
    • Journal Title

      Modern Rheumatology

      Volume: 20 Pages: 1-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293231
  • [Journal Article] Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis2014

    • Author(s)
      Mizoguchi Y, Tsumura M, Okada S, Hirata O, Minegishi S, Imai K, Hyakuna N, Muramatsu H, Kojima S, Ozaki Y, Imai T, Takeda S, Okazaki T, Ito T, Yasunaga S, Takihara Y, Bryant VL, Kong XF, Cypowyj S, Boisson-Dupuis S, Puel A, Casanova JL, Morio T, Kobayashi M.
    • Journal Title

      J Leukoc Biol

      Volume: 95 Pages: 1374-1383

    • DOI

      10.1189/jlb.0513250

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23390270, KAKENHI-PROJECT-23618008, KAKENHI-PUBLICLY-25118717, KAKENHI-PUBLICLY-25130708, KAKENHI-PROJECT-25293231, KAKENHI-PROJECT-25293232, KAKENHI-PROJECT-25713039, KAKENHI-PROJECT-25870468, KAKENHI-PROJECT-26501004, KAKENHI-PROJECT-26670501, KAKENHI-PROJECT-26670502
  • [Journal Article] Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis2014

    • Author(s)
      Morishima T, Watanabe K, Niwa A, Hirai H, Saida S, Tanaka T, Kato I, Umeda K, Hiramatsu H, Saito MK, Matsubara K, Adachi S, Kobayashi M, Nakahata T, Heike T
    • Journal Title

      Haematologica

      Volume: 99(1) Pages: 19-27

    • DOI

      10.3324/haematol.2013.083873

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390244, KAKENHI-PROJECT-24591548, KAKENHI-PROJECT-24659461, KAKENHI-PROJECT-24659496, KAKENHI-PROJECT-25293231, KAKENHI-PROJECT-25430149, KAKENHI-PROJECT-25461415, KAKENHI-PROJECT-25461591, KAKENHI-PROJECT-26670498, KAKENHI-PROJECT-26670501
  • [Journal Article] A 2-year-old Japanese girl with TNF receptor-associated periodic syndrome: A case report of the youngest diagnosed proband in Japan2014

    • Author(s)
      Yasumura J, Wago M, Okada S, Nishikomori R, Takei S, Kobayashi M
    • Journal Title

      Modern Rheumatology

      Volume: 20 Pages: 1-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670501
  • [Journal Article] Detection of <I>Mucor velutinosus</I> in a Blood Culture After Autologous Peripheral Blood Stem Cell Transplantation : A Pediatric Case Report2014

    • Author(s)
      Joichi Y, Chijimatsu I, Yarita K, Kamei K, Miki M, Onodera M, Harada M, Yokozaki M, Kobayashi M, Ohge H
    • Journal Title

      Medical Mycology Journal

      Volume: 55 Issue: 2 Pages: E43-E48

    • DOI

      10.3314/mmj.55.e43

      10.3314/mmj.55.E43

    • NAID

      130004567865

    • ISSN
      2185-6486, 2186-165X
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293231, KAKENHI-PROJECT-26670501
  • [Journal Article] Identification of the integrin β3 L718P mutation in a pedigree with autosomal dominant thrombocytopenia with anisocytosis.2013

    • Author(s)
      Kobayashi Y
    • Journal Title

      Br J Haematol

      Volume: 31 Pages: 521-529

    • DOI

      10.1111/bjh.12160

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161, KAKENHI-PROJECT-23591429, KAKENHI-PROJECT-25293231
  • [Journal Article] Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells.2013

    • Author(s)
      Hiramoto T
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 110 Pages: 3023-3028

    • DOI

      10.1073/pnas.1217039110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161, KAKENHI-PROJECT-23310137, KAKENHI-PROJECT-23650150, KAKENHI-PROJECT-23790126, KAKENHI-PROJECT-24390257, KAKENHI-PROJECT-24390272, KAKENHI-PROJECT-24659489, KAKENHI-PROJECT-25293231, KAKENHI-PLANNED-23106004
  • [Journal Article] Heterozygosity for the Y701C STAT1 mutation in a multiplex kindred with multifocal osteomyelitis.2013

    • Author(s)
      Hirata, O.
    • Journal Title

      Haematologica

      Volume: 98 Pages: 1641-1649

    • DOI

      10.3324/haematol.2013.083741

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-25118717, KAKENHI-PROJECT-25293231, KAKENHI-PROJECT-25670477, KAKENHI-PROJECT-25713039, KAKENHI-PROJECT-25870468
  • [Journal Article] Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia-derived pluipotent stem cells with heterozygous ELANEmutation2013

    • Author(s)
      Hiramoto T, Ebihara Y, Mizoguchi Y, Nakamura K, Yamaguchi K, Ueno K, Mochizuki S, Yamamoto S, Nagasaki M, Furukawa Y, Tani K, Nakauchi H, Kobayashi M, Tsuji K
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110 Pages: 3023-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] : IL-21 signalling via STAT3 primes human naïve B cells to respond to IL-2 to enhance their differentiation into plasmablasts.2013

    • Author(s)
      Berglund LJ, Ma CS, Avery DT, Moens L, Deenick EK, Bustamante J, Boisson-Dupuis S, Wong M, Adelstein S, Arkwright PD,Fulcher DA, Ziegler JB, Smart JM, Kobayashi M, Casanova JL, Cook MC, Uzel G, Tangye SG
    • Journal Title

      Blood

      Volume: 122 Pages: 3940-3950

    • DOI

      10.1182/blood-2013-06-506865

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293231
  • [Journal Article] Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells.2013

    • Author(s)
      Deenick EK, Avery DT, Chan A, Berglud LJ, Ives ML, Bustamante J, Boisson-Dupuis S, Tsumura M, Kobayashi M, Arkwright PD, Averbuch D, Engelhard D, Roesler J, Peake J, Wong M, Adelstein S, Choo S, Smart JM, French MA, Fulcher DA, Cook MC, Picard C, Durandy A, Klein C, Holland SM, Uzel G, Casanova JL, Ma CS, Tangye SG
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 210 Pages: 2739-2753

    • DOI

      10.1084/jem.20130323

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293231, KAKENHI-PROJECT-25870468
  • [Journal Article] Identification of the integrin b3 L718P mutation in a pedigree with autosomal dominant thrombocytopenia with anisocytosis2013

    • Author(s)
      Kobayashi Y, Matsui H, Kanai A, Tsumura M, Okada S, Miki M, Nakamura K, Kunishima S, Inaba T, Kobayashi M
    • Journal Title

      British Journal of Haematology

      Volume: 160 Pages: 521-529

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.2013

    • Author(s)
      Ives ML, Ma CS, Palendira U,Chan A, Bustamante J, Boisson-Dupuis S, Arkwright PD, Engelhard D, Averbuch D, Magdorf K, Roesler J, Peake J, Wong M, Adelstein S, Choo S, Smart JM, Frnch MA, Fulcher DA, Cook MC, Picard C, Durandy A, Tsumura M, Kobayashi M, Uzel G, Casanova JL, Tangye SG, Deenick EK
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 132 Pages: 400-411

    • DOI

      10.1016/j.jaci.2013.05.029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293231, KAKENHI-PROJECT-25870468
  • [Journal Article] Transmission of a maternal EDTA-dependent anticoagulant.2012

    • Author(s)
      Ohno N, Kobayashi M, Hayakawa S, Utsunomiya A, Karakawa
    • Journal Title

      Platelets

      Volume: 23 Pages: 399-400

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Oncogenic fusion E2A-HLF sensitizes t(17:19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors2012

    • Author(s)
      Zhang X, Inukai T, Hirose K, Akahane K, Kuroda I, Honna-Oshiro H, Kagami K, Goi K, Nakamura K, Kobayashi M, Endo M, Yagita H, Kurosawa H, Look TA, Honda H, Inaba T, Nakazawa S, Sugita K
    • Journal Title

      Leukemia

      Volume: 26 Pages: 2843-93

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Frequent somatic mosaicism of NEMO in T cells of patients with X-linked anhidrotic ectodermal dysplasia and immunodeficiency2012

    • Author(s)
      Kawai T, Nishikomori R, Izawa K, Murata Y, Tanaka N, Sakai H, Saito M, Yasumi T, Takaoka Y, Nakahata T, Mizukami T, Nunoi H, Kiyohara Y, Yoden A, Murata T, Sasaki S, Ito E, Akutagawa H, Kawai T, Imai C, Okada S, Kobayashi M, Heike T
    • Journal Title

      Blood

      Volume: 119 Pages: 5458-5466

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] 輸血後蕁麻疹発症前の末梢血一般検査所見2012

    • Author(s)
      梶梅輝之,浅野孝基,世羅康彦,小林正夫
    • Journal Title

      アレルギー

      Volume: 61 Pages: 1086-1091

    • NAID

      110009495640

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Regulation of hematopoietic stem cells using transduction domain-fused polycomb2012

    • Author(s)
      Kajiume T, Sera Y, Kawahara Y, Matsumoto M, Fukazawa T, Imura T, Yuge L, Kobayashi M
    • Journal Title

      Experimantal Hematology

      Volume: 40 Pages: 751-760

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] 慢性皮膚粘膜カンジダ症と機能獲得性STAT1 変異2012

    • Author(s)
      溝口洋子,津村弥来,岡田 賢,小林正夫
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 57 Pages: 437-443

    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Dominant-negative STAT1 SH2 domain mutations in unrelated patients with Mendelian susceptibility to mycobacterial disease2012

    • Author(s)
      Tsumura M, Okada S, Sakai H, Yasunaga S, Ohtsubo M, Murata T, Obata H, Yasumi T, Kong XF, Abhyankar A, Heike T, Nakahata T, Nishikomori R, Al-Muhsen S, Boisson-Dupuis S, Casanova JL, Alzahrani M, Shehri MA, Elghazali G, Takihara Y, Kobayashi M
    • Journal Title

      Human Mutation

      Volume: 33 Pages: 1377-1387

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Glanzmann thrombasthenia (GT) の遺伝子組み換え活性型第Glanzmann thrombasthenia (GT) の遺伝子組み換え活性型第VII因子製剤による止血効果因子製剤による止血効果2012

    • Author(s)
      溝口洋子,鎌田綾,三木瑞香,谷博雄,世羅康彦,中村和洋,小林正夫
    • Journal Title

      日本小児血液・がん学会雑誌

      Volume: 49 Pages: 61-66

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Quantification of κ-deleting recombination excision circles in Guthrie cards for the identification of early B-cell maturation defects2011

    • Author(s)
      Nakagawa N, Imai K, Kanegane H, Sato H, Yamada M, Kondoh K, Okada S, Kobayashi M, Agematsu K, Takada H, Mitsuiki N, Oshima K, Ohara O, Suri D, Rawat A, Singh S, Pan-Hammarstrom Q, Hammarstrom L, Reichenbach J, Seger R, Ariga T, Hara T, Miyawaki T, Nonoyama S
    • Journal Title

      Journal of Allergy & Clinical Immunology

      Volume: 128 Pages: 223-225

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Clinical and host genetic characteristics of Mendelian susceptibility to mycobacterial diseases in Japan2011

    • Author(s)
      Hoshina T, Kobayashi M, et al
    • Journal Title

      Journal of Clinical Immunology

      Volume: 31 Pages: 309-314

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Gain of function of human STAT1 mutations impair IL17 immunity and underlie chronic mucocutaneous candidiasis2011

    • Author(s)
      Liu L, Okada S, Kong XF, Kreins AY, Cypowyj S, Abhyankar A, Toubiana J, Itan Y, Audry M, Nitschke P, Masson C, Toth B, Flatot J, Migaud M, Chrabieh M, Kochetkov T, Bolze A, Borghesi A, Toulon A, Hiller J, Eyerich S, Eyerich K, Gulacsy V, Chernyshova L, Chernyshov V, Bondarenko A, Maria Cortes Grimaldo R, Blancas-Galicia L, Madrigal Beas IM, Roesler J, Magdorf K, Engelhard D, Thumerelle C, Burgel PR, Hoernes M, Drexel B, Seger R, Kusuma T, Jansson AF, Sawalle-Belohradsky J, Belohradsky B, Jouanguy E, Bustamante J, Bue M, Karin N, Wildbaum G, Bodemer C, Lortholary O, Fischer A, Blanche S, Al-Muhsen S, Reichenbach J, Kobayashi M, Rosales FE, Lozano CT, Kilic SS, Oleastro M, Etzioni A, Traidl-Hoffmann C, Renner ED, Abel L, Picard C, Marodi L, Boisson-Dupuis S, Puel A, Casanova JL
    • Journal Title

      Journal of Experimental Medicine

      Volume: 208 Pages: 1635-48

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Decreased Expression in Nuclear Factor-κB Essential Modulator Due to a Novel Splice-Site Mutation Causes X-linked Ectodermal Dysplasia with Immunodeficiency2011

    • Author(s)
      Karakawa S, Okada S, Tsumura M, Mizoguchi Y, Ohno N, Yasunaga S, Ohtsubo M, Kawai T, Nishikomori R, Sakaguchi T, Takihara Y, Kobayashi M
    • Journal Title

      Journal of Clinical Immunology

      Volume: 31 Pages: 762-77

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Clinical and host genetic characteristics of Mendelian susceptibility to mycobacterial diseases in Japan2011

    • Author(s)
      Hoshina T, Takada H, Sasaki-Mihara Y, Kusuhara K, Ohshima K, Okada S, Kobayashi M, Ohara O, Hara T
    • Journal Title

      Journal of Clinical Immunology

      Volume: 31 Pages: 309-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Quantification of k-deleting recombination excision in Guthrie cards for identi fication of early B-cell maturation defects2011

    • Author(s)
      Nakagawa K, Kobayashi M, et al
    • Journal Title

      Journal of Allergy & Clinical Immunology

      Volume: 128 Pages: 223-225

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Gain of function of human STAT1 mutations impair IL17 immunity and undelie chronic mucocutaneous candidiasis2011

    • Author(s)
      Liu L, Kobayashi M, et al
    • Journal Title

      Journal of Experimental Medicine

      Volume: 208 Pages: 1635-1648

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Decreased expression in nuclear factor-kB essential modulator due to a novel-site mutation causes X-linked ectordermal dysplasia with immunodeficiency2011

    • Author(s)
      Karakawa S, Kobayashi M, et al
    • Journal Title

      Journal of Clinical Immunology

      Volume: 31 Pages: 762-772

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Molecular pathogenesis of a novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency2010

    • Author(s)
      Shirao K, Okada S, Tajima G, Tsumura M, Hara K, Yasunaga S, Ohtsubo M, Hata I, Sakura N, Shigematsu Y, Takihara Y, Kobayashi M
    • Journal Title

      Human Genetics

      Volume: 127 Pages: 619-28

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Significance of immature platelet fraction and CD-41-positive cells at birth in early onset neonatal thrombocytopenia.2010

    • Author(s)
      Kihara H, Kobayashi M, et al.
    • Journal Title

      International Journal of Hematology

      Volume: 91 Pages: 245-251

    • NAID

      10026111410

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential.2010

    • Author(s)
      Ohno Y, Kobayashi M, et al.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 107 Pages: 21529-21534

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential2010

    • Author(s)
      Ohno Y, Yasunaga S, Ohtsubo M, Ori S, Tsumura M, Okada S, Ohta T, Kiyoshi Ohtani, Kobayashi M, Takihara Y
    • Journal Title

      Proc. Natl. Acad. Sci

      Volume: 107(50) Pages: 21529-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Maternal breast milk odour induces frontal lobe activation in neonates.2010

    • Author(s)
      Aoyama S, Kobayashi M, et al.
    • Journal Title

      Early Human Development

      Volume: 86 Pages: 541-545

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] 血液疾患における病態解析研究の進歩:先天性好中球減少症発症機構解明の進展2010

    • Author(s)
      溝口洋子, 岡田賢, 小林正夫
    • Journal Title

      血液・腫瘍科

      Volume: 127 Pages: 118-628

    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] 好中球減少症2010

    • Author(s)
      溝口洋子, 小林正夫
    • Journal Title

      小児科

      Volume: 51 Pages: 985-994

    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Hematological malignancies in congenital neutropenia2010

    • Author(s)
      Okada S, Nakamura K, Kobayashi M
    • Journal Title

      Rinsho Ketsueki

      Volume: 51 Pages: 553-558

    • NAID

      130004501411

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Significance of immature platelet fraction and CD-41-positive cells at birth in early onset neonatal thrombocytopenia2010

    • Author(s)
      Kihara H, Ohno N, Karakawa W, Mizoguchi Y, Fukuhara R, Hayashidani M, Nomura S, Nakamura K, Kobayashi M
    • Journal Title

      International Journal of Hematology

      Volume: 91 Pages: 245-251

    • NAID

      10026111410

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Molecular pathogenesis of a novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency.2010

    • Author(s)
      Shirao K, Kobayashi M, et al.
    • Journal Title

      Human Genetics

      Volume: 127 Pages: 619-628

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] 血液疾患における病態解析研究の進歩:先天性好中球減少症発症機構解明の進展2010

    • Author(s)
      溝口洋子,岡田 賢,小林正夫
    • Journal Title

      血液・腫瘍科

      Volume: 60(2) Pages: 118-124

    • Data Source
      KAKENHI-PROJECT-22591161
  • [Journal Article] Ela2 mutations and clinical manifestations in familial congenital neutropenia2009

    • Author(s)
      Shiohara M, Shigemura T, Saito S, Tanaka M, Yanagisawa R, Sakashita K, Asada H, Ishii E, Koike K, Chin M, Kobayashi M, Koike K
    • Journal Title

      Journal of Pediatric Hematology Oncology 31

      Pages: 319-324

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] Cardiac infiltration in Early-Onset Sarcoidosis Associated with a Novel Heterozygous Mutation, G481D, in CARD152009

    • Author(s)
      Okada S, Konishi N, Tsumura M, Shirao K, Yasunga S, Sakai H, Nishikomori R, Takihara Y, Kobayashi M
    • Journal Title

      Rheumatology (in press)

      Pages: 1093-1094

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] 重症先天性好中球減少症の分子病態2009

    • Author(s)
      小林正夫 ,岡田賢 ,溝口洋子
    • Journal Title

      分子細胞治療 8

      Pages: 110-116

    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] Respiratory complications after haematopoietic stem cell transplantation in a patient with chronic granulomatous disease2009

    • Author(s)
      Hara K, Kajiume T, Kondo T, Sera Y, Kawaguchi H, Kobayashi M
    • Journal Title

      Journal of Transfusion Medicine (in press)

      Pages: 0-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] Short-term culture of umbilical cord blood-derived CD34^+ cells enhances the engraftment into NOD/SCID mice through the increased expression of CXCR42009

    • Author(s)
      Ohno N, Kajiume T, Sera Y, Sato T, Kobayashi M
    • Journal Title

      Stem Cells & Developments (in press)

      Pages: 0-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] Reciprocal expression of Bmi1 and Mel-18 is associated with the functioning of primitive hematopoietic cells2009

    • Author(s)
      Kajiume T, Ohno N, Sera Y, Kawahara Y, Yuge L, Kobayashi M
    • Journal Title

      Experimental Hematology (in press)

      Pages: 0-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] Deficiency of regulatory T cells in children with autoimmune neutropenia2009

    • Author(s)
      Nakamura K, Miki M, Karakawa S, Sato T, Kobayashi M
    • Journal Title

      British Journal of Haematology (in press)

      Pages: 0-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity.2008

    • Author(s)
      Ohtsubo M, Yasunaga s, Ohno Y, Kobayashi M, Takihara Y, et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 105

      Pages: 10396-10401

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] 好中球異常による先天性免疫不全症2008

    • Author(s)
      岡田賢, 津村弥来, 小林正夫
    • Journal Title

      小児科臨床 61

      Pages: 1791-1796

    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] Development of a new enzymatic diagnosis method for very-long-chain acyl-CoA dehydrogenase deficiency by detecting 2-hexadecenoyl-CoA production and its application in tandem mass spectrometry-based selective screening and newborn screening in Japan2008

    • Author(s)
      Tajima G, Sakura N, Shirao K, Okada S, Tsumura M, Nishimura Y, Ono H, Hata I, Naito E, Yamaguchi S, Shigematsu Y, Kobayashi M
    • Journal Title

      Pediatric Research 64

      Pages: 667-672

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] Neurodevelopmental abnormalities associated with severe congenital neutropenia due to the R86X mutation in the HAX1 gene2008

    • Author(s)
      Ishikawa N, Okada S, Miki M, Shirao K, Kihara H, Tsumura M, Nakamura K, Kawaguchi H, Ohtsubo M, Yasunaga S, Matsubara K, Sako M, Hara J, Shiohara M, Kojima S, Sato T, Takihara Y, Kobayashi M
    • Journal Title

      Journal of Medical Genetics 45(12)

      Pages: 802-807

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] Neurodevelopmental abnormalities associated with severe congenital neutropenia due to the R86X mutation in the HAX1 gene.2008

    • Author(s)
      Ishikawa N, Okada s, Miki M, Takihara Y, Kobayashi M, et al
    • Journal Title

      Journal of Medical Genetics 45

      Pages: 802-807

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] The mobility of Bach2 nuclear foci is regulated by SUMO-1 modification2008

    • Author(s)
      Kono K, Harano Y, Hoshino H, Kobayashi M, Bazett-Jones DP, Muto A, Igarashi K, Tashiro S
    • Journal Title

      Experimental Cell Research 314(4)

      Pages: 903-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] Short-term culture of umbilical cord blood-derived CD34^+ cells enhances the engraftment into NOD/SCID mice through the increased expression of CXCR4.2008

    • Author(s)
      Ohno N, Kajiume T, Sera Y, Satoh T, Kobayashi M
    • Journal Title

      Stem Cells & Development (Epub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] 好中球異常症2008

    • Author(s)
      小林正夫, 世羅康彦, 岡田賢
    • Journal Title

      アレルギー・免疫 15

      Pages: 1350-1360

    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] 非結核性抗酸菌による多発性骨髄炎を呈したインターフェロンγ受容体1 異常症の2例2008

    • Author(s)
      岡田賢, 末永麻由美, 川口浩史, 小林正夫
    • Journal Title

      日本小児科学会雑誌 112

      Pages: 1818-1825

    • NAID

      10024842949

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity2008

    • Author(s)
      Ohtsubo M, Yasunaga S, Ohno Y, Tsumura M, Okada S, Ishikawa N, Shirao K, Kikuchi A, Nishitani H, Kobayashi M, Takihara Y
    • Journal Title

      Proc. Natl. Acad. Sci. USA 105(30)

      Pages: 10396-10401

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] Floating culture promotes the maintenance of hematopoietic stem cells.2007

    • Author(s)
      Kajiume T, Yuge L, Kawahara Y, Kobayashi M, et. al.
    • Journal Title

      FEBS Letters 581

      Pages: 4645-4650

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] Severe developmental delay and epilepsy in a Japanese patient with severe congenital neutropenia due to HAX1 deficiency.2007

    • Author(s)
      Matsubara K, Imai K, Okada S, Kobayashi M, et. al.
    • Journal Title

      Haematologica 92

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] The novel IFNGR1 mutation 774del4 produces a truncated form of interferon-γ receptor 1 and has a dominant-negative effect on interferon-γ signal transduction.2007

    • Author(s)
      Okada S, Ishikawa N, Kobayashi M, et. al.
    • Journal Title

      Journal of Human Genetics 44

      Pages: 485-491

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Journal Article] Acomparison of the defective granulopoiesis in childhood cyclicneutropenia and in severe congenital neuropenia.2005

    • Author(s)
      Sera, Y., Kawaguchi, H., Nakamura, K., Sato, T., Habara, M., Okada, S., Ihikawa, N., Katoh.O., Kobayashi, M.
    • Journal Title

      The hematology Journal 908. 90

      Pages: 1032-1047

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14201012
  • [Journal Article] Congenital neutropenia in infants.2005

    • Author(s)
      Kobayashi, M.
    • Journal Title

      The Journal of the Japan Pediatiric Society 109,5

      Pages: 614-622

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14201012
  • [Journal Article] Acomparison of the defective granulopoiesis in childhood cyclicneutropenia and in severe congenital neuropenia2005

    • Author(s)
      Sera, Y., Kawaguchi, H., Nakamura, K., Sato, T., Habara, M., Okada, S., Ihikawa, N., Katoh, O., Kobayashi, M.
    • Journal Title

      The hematology Journal 908・90

      Pages: 1032-1047

    • Data Source
      KAKENHI-PROJECT-14201012
  • [Journal Article] 小児好中球減少症.2005

    • Author(s)
      小林 正夫
    • Journal Title

      日本小児科学会雑誌 109・5

      Pages: 614-622

    • NAID

      10016669544

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14201012
  • [Journal Article] Neutropenia in childhood.2005

    • Author(s)
      Kobayashi M
    • Journal Title

      Japanese Journal of the Japan Pediatric Society 109

      Pages: 614-622

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591111
  • [Journal Article] 小児好中球減少症2005

    • Author(s)
      小林 正夫
    • Journal Title

      日本小児科学会雑誌 109

      Pages: 614-622

    • NAID

      10016669544

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591111
  • [Journal Article] Acomperison of the defective granulopoiesis in childood cyclicneutropenia and in severe congenital neuropenia2005

    • Author(s)
      Sera, Y., Kawaguchi, H., Nakamura, K., Sato, T., Habara, M., Okaba, S., Ihikawa, N., Katoh.O, Kobayashi,M.
    • Journal Title

      The hematology Journal 908・90

      Pages: 1032-1047

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14201012
  • [Journal Article] 周期性好中球減少症2005

    • Author(s)
      川口浩史, 中村和洋, 小林正夫
    • Journal Title

      血液フロンティア 15

      Pages: 69-75

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591111
  • [Journal Article] Cyclic neutropenia2005

    • Author(s)
      Kawaguchi H, Nakamura K, Kobayashi M
    • Journal Title

      Hematology Frontier 15

      Pages: 69-75

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591111
  • [Journal Article] 小児好中球減少症.2005

    • Author(s)
      小林正夫
    • Journal Title

      日本小児科学会雑誌 109・5

      Pages: 614-622

    • NAID

      10016669544

    • Data Source
      KAKENHI-PROJECT-14201012
  • [Journal Article] Significance of human neutrophil antigen-2a (NB1) expression and neutrophil number in pregnancy.2004

    • Author(s)
      Taniguchi K, Kobayashi M, et al.
    • Journal Title

      Transfusion 44

      Pages: 581-585

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591111
  • [Journal Article] Significance of human neutrophil antigen-2a (NB1) expression and neutrophil number in pregnancy.2004

    • Author(s)
      Taniguchi K, Nagata H, Katsuki I, Nakashima C, Onodera R, Hiraoka A, Takata N, Kobayashi M, Kambe M
    • Journal Title

      Transfusion 44

      Pages: 581-585

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591111
  • [Journal Article] G-CSF製剤,Epo製剤,M-CSF製剤2004

    • Author(s)
      小林正夫, 佐藤 貴, 上田一博
    • Journal Title

      小児科診療 67

      Pages: 570-576

    • Data Source
      KAKENHI-PROJECT-15591111
  • [Journal Article] Efficacy of the prophylactic use of trimethoprim-sulfamethoxazole in auotimmune neutropenia in infancy.2003

    • Author(s)
      Kobayashi M, Sato T, et al.
    • Journal Title

      Journal of Pediatric Hematology/Oncology 25

      Pages: 553-557

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591111
  • [Journal Article] Dysregulation of transcriptions in primary granule constituents during myeloid proliferation and differentiation in patients with severe congenital neutropenia.2003

    • Author(s)
      Kawaguchi H, Kobayashi M, Nakamura N, Konishi N, Miyagawa S, Sato T, Toyota H, Komada Y, Kojima S, Todoroki Y, Ueda K, Katoh O
    • Journal Title

      Journal of Leukocyte Biology 73

      Pages: 225-234

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591111
  • [Journal Article] 血液腫瘍疾患児の入院生活のストレスに関する研究-II.ストレッサーの同定と意義-2003

    • Author(s)
      原 美智子, 平賀 健太郎, 浜本 和子, 藤本 和美, 上田 一博, 小林 正夫
    • Journal Title

      日本小児血液学雑誌 17・3

      Pages: 117-122

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14201012
  • [Journal Article] 血液腫瘍疾患児の入院生活のストレスに関する研究-I.ストレッサーの同定と意義-2003

    • Author(s)
      原 美智子, 平賀 健太郎, 浜本 和子, 藤本 和美, 上田 一博, 小林 正夫
    • Journal Title

      日本小児血液学雑誌 17・3

      Pages: 111-116

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14201012
  • [Journal Article] Study on the stress in hospitalized children with hemato-oncological diseases,. I. The significance of identification of stressors.2003

    • Author(s)
      Hara, M., Hiraga, K., Hamamoto, K., Fujimoto, K., Ueda, K., Kobayashi, M.
    • Journal Title

      The Japanese Journal of Pediatric Hematology 17,3

      Pages: 111-116

    • NAID

      10012212057

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14201012
  • [Journal Article] Dysregulation of transcriptions in primary granule constituents during myeloid proliferation and differentiation in patients with severe congenital neutropenia.2003

    • Author(s)
      Kawaguchi H, Kobayashi M, et al.
    • Journal Title

      Journal of Leukocyte Biology 73

      Pages: 225-234

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591111
  • [Journal Article] Study on the stress in hospitalized children with hemato-oncological diseases., II. The factors causing stressful condition.2003

    • Author(s)
      Hara, M., Hiraga, K., Hamamoto, K., Fujimoto, K., Ueda, K., Kobayashi, M.
    • Journal Title

      The Japanese Journal od Pediatric Hematology 17,3

      Pages: 117-122

    • NAID

      10012212069

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14201012
  • [Journal Article] 慢性腎疾患患児のストレッサーの評価-ネフローゼ症候群と慢性腎炎の比較2002

    • Author(s)
      平賀 健太郎, 小林 正夫
    • Journal Title

      小児保健研究 61・6

      Pages: 799-805

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14201012
  • [Presentation] Successful Bone Marrow Transplantation Using an Immunomyelosuppressive Conditioning in Patients with Severe Congenital Neutropenia: The Results of a Single-Institute.2019

    • Author(s)
      Risa Matsumura, Shiho Nishimura, Yoko Mizoguchi, Mizuka Miki, Maki Taniguchi,Maiko Shimomura, Shuhei Karakawa, Shinji Mochizuki, Takehiko Doi,Hiroshi Kawaguchi, and Masao Kobayashi
    • Organizer
      The 61st Annual Meeting and Exposition of American Society of Hematology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07847
  • [Presentation] 初診時に意識障害、呼吸障害、腎障害など多彩な全身症状を呈したBCP-ALLの一例2018

    • Author(s)
      江口勇太、望月慎史、小林正夫、他
    • Organizer
      第121回日本小児科学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K19600
  • [Presentation] 両側多発性腎腫瘍の一例 A case of bilateral multifocal renal tumors.2017

    • Author(s)
      野間康輔、望月慎史、小林正夫、他
    • Organizer
      第59回日本小児血液がん学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K19600
  • [Presentation] Mixed-phenotype acute leukemia with B, T, and myeloid lineages - a pediatric case -2017

    • Author(s)
      野間康輔、望月慎史、小林正夫、他
    • Organizer
      第79回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K19600
  • [Presentation] MSMD Patients with IFN-γ-STAT1 Signaling Defect Present Enhanced Osteoclastogenesis and Bone Resorption.2015

    • Author(s)
      Nishimura S, Tsumura M, Hirata O, Reiko Kagawa, Mizoguchi Y, Okada S, Kobayashi M
    • Organizer
      The 57th American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2015-12-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670501
  • [Presentation] Impairment of IL-17 immunity to Candida and IFNγ immunity to Mycobacterium in humans with bi-allelic Rorc mutations.2015

    • Author(s)
      Okada S, Markle J, Kobayashi M, Bustamante J, Casanova JL
    • Organizer
      The 57th American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2015-12-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670501
  • [Presentation] 好中球異常症:診断と造血幹細胞移植2015

    • Author(s)
      小林正夫
    • Organizer
      第77回日本血液学会教育講演
    • Place of Presentation
      金沢
    • Year and Date
      2015-10-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670501
  • [Presentation] MSMD Patients with IFN-γ-STAT1 Signaling Defect Present Enhanced Osteoclastogenesis and Bone Resorption.2015

    • Author(s)
      Nishimura S, Tsumura M, Hirata O, Reiko Kagawa, Mizoguchi Y, Okada S, Kobayashi M
    • Organizer
      The 57th American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2015-12-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293231
  • [Presentation] A comparison of myelopoiesis from induced pluripotent stem cells with a mutation in ELANE between cyclic neutropenia and sever congenital neutropenia.2015

    • Author(s)
      Saito S, Nishimura S, Tsumra M, Mizoguchi Y, Sakata S, Furue A, Kobayashi M
    • Organizer
      The 57th American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2015-12-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670501
  • [Presentation] 好中球異常症:診断と造血幹細胞移植2015

    • Author(s)
      小林正夫
    • Organizer
      第77回日本血液学会
    • Place of Presentation
      金沢
    • Year and Date
      2015-10-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293231
  • [Presentation] A comparison of myelopoiesis from induced pluripotent stem cells with a mutation in ELANE between cyclic neutropenia and sever congenital neutropenia.2015

    • Author(s)
      Saito S, Nishimura S, Tsumra M, Mizoguchi Y, Sakata S, Furue A, Kobayashi M
    • Organizer
      The 57th American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2015-12-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293231
  • [Presentation] Impairment of IL-17 immunity to Candida and IFNγ immunity to Mycobacterium in humans with bi-allelic Rorc mutations.2015

    • Author(s)
      Okada S, Markle J, Kobayashi M, Bustamante J, Casanova JL
    • Organizer
      The 57th American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2015-12-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293231
  • [Presentation] Genetic characteristic of patients with severe congenital neutropenia in Japan.2013

    • Author(s)
      Masao Kobayashi, Yoko Mizoguchi, Shuhei Karakawa, Satoshi Okada, Hiroshi Kawaguchi, Kazuhiro Nakamura
    • Organizer
      27th International Congress of Pediatrics
    • Place of Presentation
      Melbourne, Australia
    • Data Source
      KAKENHI-PROJECT-25293231
  • [Presentation] Gain-of-function mutations of STAT1 in Japanese patients with CMCD2012

    • Author(s)
      Osamu Hirata, Miyuki Tsumura, Yoko Mizoguchi, Satoshi Okada, Shizuko Minegishi, Tomohiro Morio, Masao Kobayashi
    • Organizer
      European Society for Immunodeficiency
    • Place of Presentation
      Florence, Italy
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] Identification of integrin b3 L718P mutation in a pedigree with autosomal dominant macrothrombocytopenia2012

    • Author(s)
      Yoshiyuki Kobayashi, Hirotaka Matsui, Akinori Kanai, Miyuki Tsumura, Satoshi Okada, Mizuka Miki, Kazuhiro Nakamura, Shinji Kunishima, Toshiya Inaba and Masao Kobayashi
    • Organizer
      American Society of Hematology
    • Place of Presentation
      Atlanta, GA
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] Identification of the integrin B3 L718P mutation in a pedigree with autosomal dominant thrombocytopenia with anisocytosis.2012

    • Author(s)
      Kobayashi Y
    • Organizer
      The 54th Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta, GA, USA
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] A Nobel Method using Extracted Human Neutrophil Antigens from HNA gene-transfected cell lines for Detection of Antibodies against Human Neutrophil Antigens2012

    • Author(s)
      Rie Onodera, Kazuhiro Nakamura, Kikuyo Taniguchi, Emi Kurita, Asako Hiraoka, Kaduta Yasui, Nobuki Matsuyama, Fumiya Hirayama, and Masao Kobayashi
    • Organizer
      American Society of Hematology
    • Place of Presentation
      Atlanta, GA
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] Clinical and genetic characteristics of patients with severe congenital neutropenia in Japan2011

    • Author(s)
      Mizoguchi Y, Nakamura K, Karakawa S, Okada S, Kawaguchi H, Kobayashi M
    • Organizer
      53rd American Society of Hematology Annual Meeting
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] JAK2 mutations and CRLF2 rearrangements in Down syndrome-associated acute lymphoblastic leukemia in Japan2011

    • Author(s)
      Hanada I, Kobayashi M, et al
    • Organizer
      53^<rd> American Society of Hematology Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] Clinical and genetic characteristics of patients with severe congenital neutropenia in Japan2011

    • Author(s)
      Mizoguchi Y, Kobayashi M, et al
    • Organizer
      53^<rd> American Society of Hematology Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] JAK2 mutations and CRLF2 rearrangements in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan2011

    • Author(s)
      Hanada I, Terui K, Toki T,Kudo K, Sato T, Kamio T, Sasaki S,Takahashi Y, Hayashi Y, Sugita K, Kojima S, Koike K, Kosaka Y, Kobayashi M, Ito E
    • Organizer
      53rdAmerican Societey of Hematology Annual Meeting
    • Place of Presentation
      San Diego, CA
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] Suppressed neutrophil development in hematopoiesis of induced pluripotent stem cells derived from a severe congenital neutropenia patient with ELA2 mutation2011

    • Author(s)
      Hiramoto T, Kobayashi M, et al
    • Organizer
      53^<rd> American Society of Hematology Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] TsumuraM, Okada S, Sakai H, Nishikomori R, YasunagaS, Ohtsubo M, HeikeT, NakahataT, TakiharaY, KobayashiM2011

    • Author(s)
      TsumuraM, Okada S, Sakai H, Nishikomori R, YasunagaS, Ohtsubo M, HeikeT, NakahataT, TakiharaY, KobayashiM
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] 常染色体優性遺伝を呈する慢性皮膚粘膜カンジダ症の責任遺伝子の発見-STAT1 機能獲得性変異による慢性皮膚粘膜カンジダ症-2011

    • Author(s)
      岡田 賢,小林正夫,Luyan Liu, Xiao-Fei Kong, Alexandra Y. Kreins, Sophie Cypowyj, Laurent Abel, Capucine Picard, Stephanie Boisson-Dupuis, Anne Puel, Jean-Laurent Casanova
    • Organizer
      第39回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] Suppressed Neutrophil Development in Hematopoiesis of Induced Pluripotent Stem Cells Derived From a Severe Congenital Neutropenia Patient with ELA2 Mutation2011

    • Author(s)
      Hiramoto T, Ebihara Y, Mizoguchi Y, Nakamura K, Mochizuki S, Yamamoto S, Matsuzaka E, Hanada S, Ohnishi R, Tani K, Eto K, Nakauchi H, Kobayashi M, Tsuji K
    • Organizer
      53rdAmerican Societey of Hematology Annual Meeting
    • Place of Presentation
      San Diego, CA
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] A Novel mutation K673R in STAT1 impaired the STAT1 signal transduction in a dominant-neeative manner identified in a Japanese boy.2010

    • Author(s)
      Mizoguchi Y, Kobayashi M, et al.
    • Organizer
      American Society of Hematology (52^<nd> Annual Meeting)
    • Place of Presentation
      Orlando FL, USA
    • Year and Date
      2010-12-04
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] Umbilical cord blood-derived stem cells cultured under low oxygen tension enhance the migratioin and homing efficacy through the increased expression of CXCR4.2010

    • Author(s)
      Ohno N, Kobayashi M, et al.
    • Organizer
      American Society of Hematology (52^<nd> Annual Meeting)
    • Place of Presentation
      Orlando FL, USA
    • Year and Date
      2010-12-04
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] Decreased expression in NF-kB essential modulator due to a novel splice-site mutation causes ectodermal dysplasia with immunodeficiency2010

    • Author(s)
      Karakawa S, Okada, S, Tsumura M, Yasunaga S, Ohtsubo M, Kawai T, Nishikomori R, Takihara Y, Kobayashi M
    • Organizer
      52nd American Society of Hematology Annual Meeting
    • Place of Presentation
      Orlando FL USA
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] Umbilical cord blood-derived stem cells cultured under low oxygen tension enhance the migratioin and homing efficacy through the increased expression of CXCR42010

    • Author(s)
      Ohno N, Kajiume T, Hayakawa S, Kobayashi Y, Ytsunomiya A, Kobayashi M
    • Organizer
      52nd American Society of Hematology Annual Meeting
    • Place of Presentation
      Orlando FL USA
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] A Novel mutation K673R in STAT1 impaired the STAT1 signal transduction in a dominant-negative manner identified in a Japanese boy2010

    • Author(s)
      Mizoguchi Y, Tsumura M, Okada S, Sakai H, Nishikomori R, Yasunaga S, Ohtsubo M, Murata T, Obata H, Yasumi T, Heike T, Nakahata T, Takaihara Y, Kobayashi M
    • Organizer
      52nd American Society of Hematology Annual Meeting
    • Place of Presentation
      Orlando FL USA
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] A novel mutation K673R in STAT1 impaired the STAT1 signal transduction in a dominat-negative manner identified in a Japanese boy with MSMD.2010

    • Author(s)
      Tsumura M, Kobayashi M, et al.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-08-25
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] Decreased expression in NF-kB essential modulator due to a novel splice-site mutation causes ectodermal dysplasia with immunodeficiency.2010

    • Author(s)
      Karakawa S, Kobayashi M, et al.
    • Organizer
      American Society of Hematology (52^<nd> Annual Meeting)
    • Place of Presentation
      Orlando FL, USA
    • Year and Date
      2010-12-04
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] 小児の易感染性と食細胞異常症2010

    • Author(s)
      小林正夫
    • Organizer
      第62回北日本小児科学会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-11
    • Data Source
      KAKENHI-PROJECT-22591161
  • [Presentation] Short-Term Culture of Umbilical Cord Blood-Derived Stem Cells Enhances the Engraftment into NOD/SCID Mice through the Increased Expression of CXCR42008

    • Author(s)
      Ohno N, Kajiume T, Sera Y, Sato T, Kobayashi M
    • Organizer
      American Society of Hematology, 50th Annual Meeting
    • Place of Presentation
      San Francisco, CA, U.S.A.
    • Year and Date
      2008-12-06
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Presentation] Novel Heterozygous Mutation 572insA in TACI Identified in a Patient with Selective IgA Deficiency2008

    • Author(s)
      Okada S, Kajiume T, Tsumura M, Shirao K, Ohno Y, Yasunaga S, Ohtsubo M, Sira MM, Kanegane H, Miyawaki T, Takihara Y, Kobayashi M
    • Organizer
      American Society of Hematology, 50th Annual Meeting
    • Place of Presentation
      San Francisco, CA, U.S.A.
    • Year and Date
      2008-12-06
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Presentation] Short-Term Culture of Umbilical Cord Blood-Derived Stem Cells Enhances the Engraftment into NOD/SCID Mice through the Increased Expression of CXCR4.2008

    • Author(s)
      Ohno N, Kajiume T, Sera Y, Satoh T, Kobayashi M
    • Organizer
      American Society of Hematology, 49th Annual Meeting.
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2008-12-07
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Presentation] Reconstitution of Regulatory T Cells Involves in the Development of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation2008

    • Author(s)
      Karakawa S, Nakamura K, Hara K, Mizoguchi Y, Miki M, Kawaguchi K, Sato T, Nishimura S, Kobayashi M
    • Organizer
      American Society of Hematology, 50th Annual Meeting
    • Place of Presentation
      San Francisco, CA, U.S.A.
    • Year and Date
      2008-12-07
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Presentation] Association of Neurodevelopmental Abnormalities Is a Common Clinical Character in Japanese Patients with Severe Congenital Neutropenia Due to HAX1 Deficiency2007

    • Author(s)
      Okada S, Ishikawa N, Shirao K, Tsumura M, Sato T, Ohno Y, Yasunaga S, Ohtsubo M, Takihara Y, Kobayashi M
    • Organizer
      American Society of Hematology, 49th Annual Meeting
    • Place of Presentation
      Atlanta, GA, U.S.A.
    • Year and Date
      2007-12-10
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Presentation] Association of Neurodevelopmental Abnormalities Is a Common Clinical Character in Japanese Patients with Severe Congenital Neutropenia Due to HAX1 Deficiency.2007

    • Author(s)
      Okada S, Ishikawa N, Shirao K, Kobayashi M, et. al.
    • Organizer
      American Society of Hematology, 49th Annual Meeting.
    • Place of Presentation
      Atlanta, GA, USA
    • Year and Date
      2007-12-10
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Presentation] The Expression of Polycomb Group Genes Products, Bmi1 and Mel-18, Regulate the Function of Murine Primitive Hematopoietic Cells2007

    • Author(s)
      Kajiume T, Takashi Sato T, Kobayashi M
    • Organizer
      American Society of Hematology, 49th Annual Meeting
    • Place of Presentation
      Atlanta, GA, U.S.A.
    • Year and Date
      2007-12-08
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Presentation] The Decrease of Regulatory T Cells through the Low Levels of FOXP3 Expression Mediated by NFAT1 in Infancy with Autoimmune Neutropenia2007

    • Author(s)
      Nakamura N, Miki M, Karakawa S, Onodera R, Kurita E, Hiraoka A, Sato T, Kobayashi M
    • Organizer
      American Society of Hematology, 49th Annual Meeting
    • Place of Presentation
      Atlanta, GA, U.S.A.
    • Year and Date
      2007-12-10
    • Data Source
      KAKENHI-PROJECT-19591250
  • [Presentation] Excessive Nitric Oxide production of CGD neutrophils induces the down-regulation of NOS3 and EDN1 expression in human endothelial cells.

    • Author(s)
      Akari N. Utsunomiya, Miyuki Tsumura, Norioki Ohno, Mizuka Miki, Hiroshi Kawaguchi, Kazuhiro Nakamura and Masao Kobayashi
    • Organizer
      The 56th American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2014-12-06 – 2014-12-09
    • Data Source
      KAKENHI-PROJECT-26670501
  • [Presentation] Early elimination of Factor VIII inhibitor by ITI with high dose immunoglobulin in hemophilia A children

    • Author(s)
      Yoko Mizoguchi, Aya Furue, Ikue Chijimatsu, Mizuka Miki, Keita Tomioka, Nakao Konishi, Atsushi Ono, Hiroshi Kawaguchi, Kazuhiro Nakamura and Masao Kobayashi
    • Organizer
      WORLD FEDERATION OF HEMOPHILIA, 2014 World Congress
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2014-05-11 – 2014-05-15
    • Data Source
      KAKENHI-PROJECT-26670501
  • [Presentation] STAT1 gain-of-function in patients with chronic mucocutaneous candidiasis can be detected by the excessive phosphorylation of STAT1 in peripheral blood monocytes.

    • Author(s)
      Yoko Mizoguchi, Satoshi Okada, Miyuki Tsumura, Osamu Hirata, Shizuko Minegishi, Jean-Laurent Casanova, Tomohiro Morio, Masao Kobayashi
    • Organizer
      The 56th American Society of Hematology Annual Meeting and Expositio
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2014-12-06 – 2014-12-09
    • Data Source
      KAKENHI-PROJECT-25293231
  • [Presentation] Siginificant augmentation of regulatory T cells in early neonatal period.

    • Author(s)
      Seiich Hayakawa, Seiko Maeno, Norioki Ohno, Satoshi Okada, Yutaka Nishimura, Michiko Hayashidani, Masao Kobayashi
    • Organizer
      16th Biennial Meeting of the European Society for Immunodeficiencies
    • Place of Presentation
      Prague, Czech
    • Year and Date
      2014-10-29 – 2014-11-01
    • Data Source
      KAKENHI-PROJECT-25293231
  • [Presentation] Early elimination of Factor VIII inhibitor by ITI with high dose immunoglobulin in hemophilia A children.

    • Author(s)
      Yoko Mizoguchi, Aya Furue, Ikue Chijimatsu, Mizuka Miki, Keita Tomioka, Nakao Konishi, Atsushi Ono, Hiroshi Kawaguchi, Kazuhiro Nakamura and Masao Kobayashi
    • Organizer
      WORLD FEDERATION OF HEMOPHILIA, 2014 World Congress
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2014-05-11 – 2014-05-15
    • Data Source
      KAKENHI-PROJECT-25293231
  • [Presentation] Excessive Nitric Oxide production of CGD neutrophils induces the down-regulation of NOS3 and EDN1 expression in human endothelial cells.

    • Author(s)
      Akari N. Utsunomiya, Miyuki Tsumura, Norioki Ohno, Mizuka Miki, Hiroshi Kawaguchi, Kazuhiro Nakamura and Masao Kobayashi
    • Organizer
      The 56th American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2014-12-06 – 2014-12-09
    • Data Source
      KAKENHI-PROJECT-25293231
  • [Presentation] STAT1 gain-of-function in patients with chronic mucocutaneous candidiasis can be detected by the excessive phosphorylation of STAT1 in peripheral blood monocytes.

    • Author(s)
      Yoko Mizoguchi, Satoshi Okada, Miyuki Tsumura, Osamu Hirata, Shizuko Minegishi, Jean-Laurent Casanova, Tomohiro Morio, Masao Kobayashi
    • Organizer
      The 56th American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2014-12-06 – 2014-12-09
    • Data Source
      KAKENHI-PROJECT-26670501
  • 1.  KATOH Osamu (90214361)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  SATO Takashi (90271064)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 3.  UEDA Kazuhiro (30112189)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  KAJIUME Teruyuki (40278924)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 12 results
  • 5.  Tsumura Miyuki (80646274)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 16 results
  • 6.  Okada Satoshi (80457241)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 17 results
  • 7.  Yamamoto Takashi (90244102)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  Nakamura Kazuhiro (70363059)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 9.  FUJITA Naoto (60274081)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  TOSHIMA Tamotsu (20033566)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  Mochizuki Shinji (90349473)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 12.  浜崎 隆 (00180935)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  田中 義人 (90116624)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  坂野 堯 (80112192)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  西村 真一郎 (00228222)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  田代 聡 (20243610)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  田中 丈夫 (50127669)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  近藤 武夫 (00379869)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  松橋 有子 (10119018)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  松田 文子 (50118048)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  橋本 優花里 (70346469)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  河原 純一郎 (30322241)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  宮谷 真人 (90200188)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  原田 佳明
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  脇 千明
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  OHNO Yoshinori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  TAKEDACHI Kyoko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  KUROGI Toshiaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  MINEGISHI Shizuko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  YAMAGUCHI Rui
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  YAMAGUCHI Kiyoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  MURAMATSU Hideki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  OHARA Osamu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 34.  WATANABE Kenichiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  NIWA Akira
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  SAITOH Megumu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  IMAI Kohsuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 38.  TAKAHASHI Yoshiyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  森尾 友宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 40.  瀧原 義宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 41.  安永 晋一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 42.  峯岸 克行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 43.  國島 伸治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 44.  古川 洋一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 45.  長崎 正朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 46.  中内 啓光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 47.  小島 勢二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 48.  奥野 友介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 49.  古関 明彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 50.  佐藤 尚子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 51.  平位 秀世
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 52.  中畑 龍俊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 53.  松下 正
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 54.  鈴木 伸明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 55.  加藤 善一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 56.  高田 英俊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 57.  大西 秀典
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 58.  小林 良行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 59.  松村 到
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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