KOYAMA Yoshiyuki 小山義之

… Alternative Names

小山義之コヤマヨシユキ

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Researcher Number	00162090
Other IDs
Affiliation (Current)	2025: 東京医科大学, 医学部, 客員教授 2025: 大阪公立大学, 大学院獣医学研究科 , 客員研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪公立大学, 大学院獣医学研究科, 客員研究員 2022: 大阪公立大学, 生命環境科学研究科, 客員研究員 2016 – 2021: 大阪府立大学, 生命環境科学研究科, 客員研究員 2014 – 2015: 大阪府立大学, 生命環境科学研究科(系), 客員研究員 2013: 大妻女子大学, 家政学部, 教授 … More 2003 – 2011: 大妻女子大学, 家政学部, 教授 1997: 大妻女子大学, 家政学部, 助教授 1993: 東京理科大学, 総合研研究所, 講師 1987 – 1988: 成蹊大学, 工学部, 助手 Less
Review Section/Research Field	Principal Investigator Biomedical engineering/Biological material science / Basic Section 90120:Biomaterials-related / Biomedical engineering/Biomaterial science and engineering / Nanomaterials/Nanobioscience / Biomedical engineering/Biological material science Except Principal Investigator Obstetrics and gynecology / Biomedical engineering/Biomaterial science and engineering / 高分子合成 / Digestive surgery / Clinical oncology
Keywords	Principal Investigator 遺伝子治療 / ESAT-6 / 抗腫瘍免疫治療 / 抗腫瘍免疫 / 免疫治療 / 結核菌抗原 / インターフェロン / VA-RNA / 細胞外小胞 / ガン免疫治療 … More / 微生物抗原 / 樹状細胞 / 人工ネオエピトープ / 人工ネオアンティジェン / エクソソーム / 転写 / 三元複合体 / ネオエピトープ / ネオアンティジェン / 非ウィルスベクター / バイオテクノロジー / ナノバイオ / 糖質高分子 / 疑似感染 / 微生物遺伝子 / 結核菌 / 疑似感染状態 / EV / 抗体産生 / 免疫学 / 感染症 / 細胞性免疫 / 人工ネオ抗原 / polyampholyte / ternary complex / transcription / gene therapy / 両イオン性高分子 / HMG Protein / Transcription / Polyanion / Ternary Complex / Gene Therapy / ポリイオンコンプレックス / ターゲティング / ヒアルロン酸 / PEG / HMGタンパク / ポリアニオン / 結核菌タンパク / DNA複合体 / サイトカイン / 癌免疫療法 / デンジャーシグナル / Ag85B / 抗腫瘍効果 / プラスミドDNA / プラスミド / 遺伝子導入 / 抗腫瘍ワクチン / DNAワクチン / GM-CSF / 癌免疫治療 / 薬物伝達システム / 癌治療 / 凍結乾燥 / 核酸 / 高分子ミセル / 分子集合体 / グルコース・トランスポーター / 消化管吸収 / デキストラン … More Except Principal Investigator 遺伝子治療 / JTS-1 / Drug Delivery System / 膜透過機能 / キトサン / ポリペプチド複合体 / アミノ酸NCA / 水溶性キチン / キチン / 癌遺伝子治療 / midkineプロモーター / 固形癌 / 前臨床有効性試験 / ＧＭ－ＣＳＦ / リアルタイム定量的-PCＲ / 伴侶動物 / キャリアー細胞 / オンコリティックアノデウイルス / 動物試験 / 腫瘍 / アデノウイルス / qPCR / 安全性試験 / ビーグル犬 / オンコリティックアデノウイルス / beagle dogs / preclinical test / companion animal / oncolytic adenovirus / ガン免疫治療 / DNAワクチン / Polyamides / Polyureas / Carbohydrate Polymers / Chitosan / Diaminosugars / Chitobiose / Trehalose / ジアミノ酸 / 直接重付加反応 / ジアミノトレハロース / ポリアミド / ポリ尿素 / 糖質高分子 / ジアミノ糖 / キトビオース / トレハロース / Targeting / Multidrug resistant gene / Gene Therapy / anionic PEG complex / Polyethyleneimine / JTS-1、4 DDS / トランスポーター / DNAマクロアレイ / ターゲティング / 抗癌剤耐性遺伝子 / DNAマイクロアレイ / JTS-1,4DDS / アニオン性PEG誘導体 / ポリエチレンイミン / ヨウ素化キチン / トシル化キチン / グラフト共重合 / ガラス転移 / N-アルキリデン水溶性キチン / N-アルキリデンキトサン / N-アシルキトサン / グラフト重合 Less

微生物遺伝子を導入した疑似感染細胞が分泌する細胞外小胞による抗腫瘍免疫治療の創製Principal Investigator
- Principal Investigator
  
  小山義之
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Osaka Metropolitan University
Novel strategy of anti-tumor immune therapy using pseudo-infection exosomes presenting artificial neoepitopesPrincipal Investigator
- Principal Investigator
  
  Koyama Yoshiyuki
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Osaka Metropolitan University
  Osaka Prefecture University
Preclinical efficacy study of novel carrier cells for refractory solid tumors in companion animals
- Principal Investigator
  
  Hamada Katsuyuki
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Toho University
A novel strategy for a cancer immunotherapy and infectious disease treatment using microbial antigen-presenting exosomesPrincipal Investigator
- Principal Investigator
  
  Koyama Yoshiyuki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Osaka Prefecture University
Novel DNA vaccine strategy to elicit antitumor immune responses by transfecting with plasmids coding for pathogenic antigens
- Principal Investigator
  
  Ito Tomoko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Osaka Prefecture University
  Meiji Pharmaceutical University
Development of Novel Antitumor DNA Vaccine Utilizing a Plasmid Expressing a Mycobacterium Tuberculosis AntigenPrincipal Investigator
- Principal Investigator
  
  Koyama Yoshiyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Osaka Prefecture University
  Otsuma Women's University
PREPARATION OF SMALL PLASMID COMPLEX FOR CANCER THERAPY AND APPLICATION TO MEDIUM ANIMAL CLINICAL STUDY
- Principal Investigator
  
  YOSHIHARA Chieko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Clinical oncology
- Research Institution
  Otsuma Women's University
Novel Strategy of Tumor Gene Therapy by Very Small Plasmid Complex ParticlesPrincipal Investigator
- Principal Investigator
  
  KOYAMA Yoshiyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Otsuma Women's University
Preparation of the lyophilizable DNA complexes and novel therapeutic system with the freeze-dried solid complexesPrincipal Investigator
- Principal Investigator
  
  KOYAMA Yoshiyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nanomaterials/Nanobioscience
- Research Institution
  Otsuma Women's University
Bio-compatible gene-delivery systems with transcriptional-enhancing functionPrincipal Investigator
- Principal Investigator
  
  KOYAMA Yoshiyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Otsuma Women's University
Development of Gene Therapy with Nanotechnology derived Intelligent Drug Deliver Systems
- Principal Investigator
  
  YANAGIE Hironobu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokyo
Cell Specific Gene Delivery Systems with DNA Complexes Coated by Sugar-bearing PolyanionsPrincipal Investigator
- Principal Investigator
  
  KOYAMA Yoshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Otsuma Women's University
糖鎖を表面に持つ高分子会合体の調製とその細胞との相互作用Principal Investigator
- Principal Investigator
  
  小山義之
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Otsuma Women's University
合成糖質高分子を用いたデキストランの受容体介在消化管吸収機構の解明Principal Investigator
- Principal Investigator
  
  小山義之
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tokyo University of Science
多糖の分子設計による分離および不斉認識機能の発現
- Principal Investigator
  
  栗田恵輔
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Seikei University
多糖の分子設計による分離および不斉認識機能の発現
- Principal Investigator
  
  KURITA Keisuke
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Seikei University
Synthetic Carbohydrate Polymers Derived from Diaminosugars and Their Membrane Permeability
- Principal Investigator
  
  KURITA Keisuke
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  高分子合成
- Research Institution
  Seikei University

[Book] Molecular design for gene delivery in vivo "Non-viral Gene Therapy : Gene Design and Delivery"2005
- Author(s)
  Yoshiyuki Koyama
- Publisher
  Springer-Verlag (Berlin)(in press)
- Data Source
  KAKENHI-PROJECT-15500324
[Book] Non-viral Gene Therapy Gene Design and Delivery2005
- Author(s)
  Yoshiyuki Koyama
- Total Pages
  15
- Publisher
  Springer-Verlag(Berlin)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500324
[Journal Article] Water-Absorbing Bioadhesive Poly(Acrylic Acid)/Polyvinylpyrrolidone Complex Sponge for Hemostatic Agents2022
- Author(s)
  Ito Tomoko、Yamaguchi Shingo、Soga Daisuke、Ueda Keisuke、Yoshimoto Takayuki、Koyama Yoshiyuki
- Journal Title
  
  Bioengineering
  
  Volume: 9 Issue: 12 Pages: 755-755
- DOI
  10.3390/bioengineering9120755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12806, KAKENHI-PROJECT-21K09779, KAKENHI-PROJECT-21K11227, KAKENHI-PROJECT-21K12256
[Journal Article] Preparation of a Bioadhesive Poly(Acrylic Acid)/Polyvinylpyrrolidone Complex Gel and Its Clinical Effect on Dental Hemostasis2022
- Author(s)
  Ito Tomoko、Yamaguchi Shingo、Soga Daisuke、Yoshimoto Takayuki、Koyama Yoshiyuki
- Journal Title
  
  Gels
  
  Volume: 8 Issue: 8 Pages: 462-462
- DOI
  10.3390/gels8080462
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12806, KAKENHI-PROJECT-21K09779, KAKENHI-PROJECT-21K12256
[Journal Article] Preparation of stretchable composite film and its application in skin burn repair2021
- Author(s)
  Wang Li-Ping、Wang Hua-Jie、Hou Xue-song、Raza Ali、Koyama Yoshiyuki、Ito Tomoko、Wang Jin-Ye
- Journal Title
  
  Journal of the Mechanical Behavior of Biomedical Materials
  
  Volume: 113 Pages: 104114-104114
- DOI
  10.1016/j.jmbbm.2020.104114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12806
[Journal Article] Microbial antigen-presenting extracellular vesicles derived from genetically modified tumor cells promote antitumor activity of dendritic cells2021
- Author(s)
  Tomoko Ito, Kikuya Sugiura, Aya Hasegawa, Wakana Ouchi, Takayuki Yoshimoto, Izuru Mizoguchi, Toshio Inaba, Katsuyuki Hamada, Masazumi Eriguchi, Yoshiyuki Koyama
- Journal Title
  
  Pharmaceutics
  
  Volume: 13 Issue: 1 Pages: 57-69
- DOI
  10.3390/pharmaceutics13010057
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01390, KAKENHI-PROJECT-19K06570, KAKENHI-PROJECT-19K12806, KAKENHI-PROJECT-18K11658, KAKENHI-PROJECT-21K12256
[Journal Article] Innate immunity mediated by dendritic cells/macrophages plays a central role in the early period in tumor treatment using gene of Mycobacterium tuberculosis antigen2018
- Author(s)
  Takahiro Ushigusa, Yoshiyuki Koyama, Tomoko Ito, Kenichi Watanabe, James K. Chambers, Aya Hasegawa, Kazuyuki Uchida, Ryoji Kanegi, Shingo Hatoya, Toshio Inaba, Kikuya Sugiura
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 80 Issue: 2 Pages: 190-196
- DOI
  10.1292/jvms.17-0466
- NAID
  130006339616
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01394, KAKENHI-PROJECT-17K01390, KAKENHI-PROJECT-16H05044, KAKENHI-PROJECT-15K07747
[Journal Article] Exosomes derived from tumor cells genetically modified to express Mycobacterium tuberculosis antigen: a novel vaccine for cancer therapy.2016
- Author(s)
  Koyama Y, Ito T, Hasegawa A, Eriguchi M, Inaba T, Ushigusa T, Sugiura K.
- Journal Title
  
  Biotechnol Lett
  
  Volume: 38 Issue: 11 Pages: 1857-1866
- DOI
  10.1007/s10529-016-2185-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05044, KAKENHI-PROJECT-24380172, KAKENHI-PROJECT-26350533, KAKENHI-PROJECT-15K14888, KAKENHI-PROJECT-16K01394
[Journal Article] Effect of pDNA complex particle size on gene expression: difference between in vitro and in vivo experiments2016
- Author(s)
  Tomoko Ito, Masazumi Eriguchi, Yoshiyuki Koyama
- Journal Title
  
  Journal of Nanomaterials & Molecular Nanotechnology
  
  Volume: 5 Issue: 06 Pages: 1-5
- DOI
  10.4172/2324-8777.1000202
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26350533
[Journal Article] Novel antitumor strategy by transfection of plasmid expressing mycobacterium tuberculosis antigen as a "Danger Signal" to block immune escape of tumor cells2015
- Author(s)
  Yoshiyuki Koyama, Chieko Yoshihara, Tomoko Ito
- Journal Title
  
  Pharmaceutics
  
  Volume: 7 Issue: 3 Pages: 165-174
- DOI
  10.3390/pharmaceutics7030165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26350533, KAKENHI-PROJECT-25350555
[Journal Article] Highly effective non-viral antitumor gene therapy system comprised of biocompatible small plasmid complex particles consisting of pDNA, anionic polysaccharide, and fully deprotected linear polyethylenimine2015
- Author(s)
  Yoshiyuki Koyama, Kikuya Sugiura, Chieko Yoshihara, Toshio Inaba, Tomoko Ito
- Journal Title
  
  Pharmaceutics
  
  Volume: 7 Issue: 3 Pages: 152-164
- DOI
  10.3390/pharmaceutics7030152
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350533, KAKENHI-PROJECT-15K14888, KAKENHI-PROJECT-23380174, KAKENHI-PROJECT-25350555, KAKENHI-PROJECT-24380172
[Journal Article] Oncolytic plasmid : A novel strategy for tumor immuno-gene therapy2012
- Author(s)
  Yoshihara C., Hamada K., Kuroda M., Koyama Y.
- Journal Title
  
  Oncology Letters
  
  Volume: 3 Pages: 387-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701103
[Journal Article] Antitumor effect of chondroitin sulfate-coated ternary granulocyte macrophage-colony-stimulating factor plasmid complex for ovarian cancer2012
- Author(s)
  Hamada K., Yoshihara C., Ito T., Tani K., Tagawa M., Sakuragawa N., Itoh H., Koyama Y.
- Journal Title
  
  J Gene Med.
  
  Volume: 14 Pages: 120-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500430
[Journal Article] Novel Antitumor Strategy by Transfection of Plasmids Encoding Pathogenic Antigen- and Cytokine-Genes2012
- Author(s)
  Yoshiyuki Koyama, Chieko Yoshihara, Tomoko Ito, Ph.D.1,2 and Masazumi Eriguchi
- Journal Title
  
  American Society of Gene & Cell Therapy 15th Annual Meeting, Philadelphia, USA
  
  Volume: May Pages: 15-19
- Data Source
  KAKENHI-PROJECT-23701103
[Journal Article] Oncolytic plasmid: A novel strategy for tumor immuno-gene therapy2012
- Author(s)
  Chieko Yoshihara, Katuyuki Hamada, Minako Kuroda, Yoshiyuki Koyama
- Journal Title
  
  Oncology Letters
  
  Volume: 3 Pages: 387-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701103
[Journal Article] Antitumor effect of chondroitin sulfate-coated Ternary-granulocytemacrophage-colony-stimul ating factor plasmid complex for ovarian cancer2012
- Author(s)
  Hamada K., Yoshihara C., Ito T., Tani K., Tagawa M., Sakuragawa N., Itoh H., Koyama Y.
- Journal Title
  
  J Gene Med.
  
  Volume: 14 Pages: 120-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701103
[Journal Article] Oncolytic plasmid : A novel strategy for tumor immuno-gene therapy2012
- Author(s)
  Yoshihara C., Hamada K., Kuroda M., Koyama Y.
- Journal Title
  
  Oncology Letters
  
  Volume: 3 Pages: 387-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500430
[Journal Article] Antitumor effect of chondroitin sulfate-coated ternary granulocyte macrophage-colony-stimulating factor plasmid complex for ovarian cancer2012
- Author(s)
  Katsuyuki Hamada、Chieko Yoshihara、Tomoko Ito、Kenzaburo Tani、Masatoshi Tagawa、Norio Sakuragawa、Hiroshi Itoh、Yoshiyuki Koyama
- Journal Title
  
  THE JOURNAL OF GENE MEDICINE
  
  Volume: 14 Pages: 120-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701103
[Journal Article] Highly Effective Non-viral Antitumor Gene Therapy System Comprising Biocompatible Small Plasmid Complex Particles2011
- Author(s)
  Yoshiyuki Koyama, Chieko Yoshihara
- Journal Title
  
  American Society of Gene & Cell Therapy 14th Annual Meeting,Seattle, Washington,USA
  
  Volume: 2011.5
- Data Source
  KAKENHI-PROJECT-23701103
[Journal Article] Oncolytic Plasmid System, a Novel Antitumor Strategy by Plasmid Encoding Adenovirus Protein2011
- Author(s)
  Yoshiyuki Koyama, Chieko Yoshihara, Masahiko Tojyo, Tomoko Ito, and Katsuyuki Hamada
- Journal Title
  
  American Society of Gene & Cell Therapy 14th Annual Meeting,Seattle, Washington,USA
  
  Volume: 2011.5
- Data Source
  KAKENHI-PROJECT-23701103
[Journal Article] DNA/polyethyleneimine/hyaluronic acid small complex particles and tumor suppression in mice2010
- Author(s)
  Ito T., Yoshihara C., Hamada K., Koyama Y.
- Journal Title
  
  Biomaterials
  
  Volume: 31 Pages: 2912-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500430
[Journal Article] Loosening of DNA/polycation complexes by synthetic polyampholyte to improve the transcription efficiency : effect of charge balance in the polyampholyte2010
- Author(s)
  Yoshihara C., Shew C-Y., Ito T., Koyama Y.
- Journal Title
  
  Biophys J.
  
  Volume: 98 Pages: 1257-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500430
[Journal Article] Analysis of the surface structure of DNA/polycation/hyaluronic acid ternary complex by Raman microscopy2010
- Author(s)
  Ito T., Koyama Y., Otsuka M
- Journal Title
  
  J Pharm Biomed Anal.
  
  Volume: 51 Pages: 268-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500430
[Journal Article] Efficient in vivo Gene Transfection by Stable DNA/PEI Complexes Coated by Hyaluronic Acid2008
- Author(s)
  T. Ito, N. I.-Tanaka, Y. Koyama
- Journal Title
  
  J. Drug Targeting 16
  
  Pages: 276-281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19510119
[Journal Article] Highly efficient in vivo gene transfection by plasmid/PEI complexes coated by anionic PEG derivatives bearing carboxyl groups and RGD peptide2008
- Author(s)
  M. Sakae, T. Ito, C. Yoshihara, N. I.-Tanaka, H. Yanagie, M. Eriguchi, Y. Koyama
- Journal Title
  
  Biomedicine & Pharmacotherapy 62
  
  Pages: 448-453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19510119
[Journal Article] Preparation of Fine DNA Particles and High Level Tumor-targeted In Vivo Gene Expression after Intravenous Injection2008
- Author(s)
  T. Ito, M. Otsuka, Y. Koyama
- Journal Title
  
  Molecular Therapy 16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19510119
[Journal Article] In Vitro Gene Delivery by pDNA/Chitosan Complexes Coated with Anionic PEG Derivatives that Have a Sugar Side Chain2008
- Author(s)
  M. Hashimoto, Y. Koyama, T. Sato
- Journal Title
  
  Chem. Lett. 37
  
  Pages: 266-267
- NAID
  10021078166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19510119
[Journal Article] Enhancement of Transcriptional Activity of DNA Complexes by Amphoteric PEG Derivative2006
- Author(s)
  Yoshiyuki Koyama
- Journal Title
  
  Biomacromolecules 7
  
  Pages: 1274-1279
- Data Source
  KAKENHI-PROJECT-17500315
[Journal Article] Enhancement of Transcriptional Activity of DNA Complexes by Amphoteric PEG Derivative2006
- Author(s)
  Y. Koyama, et. al.
- Journal Title
  
  Biomacromolecules 7
  
  Pages: 1274-1279
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500315
[Journal Article] Enhancement of Transcriptional Activity of DNA Complexes by Amphoteric PEG Derivative2006
- Author(s)
  Y. Koyama
- Journal Title
  
  Biomacromolecules 7
  
  Pages: 1274-1279
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500315
[Journal Article] Shielding of Cationic Charge of the DNA Complex to Avoid Nonspecific Interaction for In vivo Gene Delivery2005
- Author(s)
  Yoshiyuki Koyama
- Journal Title
  
  Non-viral Gene Therapy
  
  Pages: 211-225
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500324
[Journal Article] Novel Receptor-Mediated Gene Transfection Systems Comprising Plasmid / Polycation / RGD-PEG-COOH Ternary2004
- Author(s)
  M.Sakae, Y.Koyama et al.
- Journal Title
  
  Molecular Therapy 9
  
  Pages: 319-319
- Data Source
  KAKENHI-PROJECT-15500324
[Journal Article] Novel Receptor-mediated Gene Delivery System Comprising Plasmid / Protamine / Sugar-containing Polyanion Ternary Co2004
- Author(s)
  K.Maruyama Y.Koyama et al.
- Journal Title
  
  Biomaterials 25
  
  Pages: 3267-3273
- Data Source
  KAKENHI-PROJECT-15500324
[Journal Article] Hyaluronic Acid as a Self Assembled Coating of Plasmid / Polvcation Complexes for Cell-Specific Gene Delivery2004
- Author(s)
  T.Ito Y.Koyama et al.
- Journal Title
  
  Molecular Therapy 9
  
  Pages: 321-322
- Data Source
  KAKENHI-PROJECT-15500324
[Journal Article] Novel poly(ethylene glycol) derivatives with carboxylic acid pendant groups : synthesis and their protection and enhancing effect on non-viral gene transfection systems2003
- Author(s)
  Yoshiyuki Koyama
- Journal Title
  
  J.Biomater.Sci.Polymer Edn. 14
  
  Pages: 515-531
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500324
[Journal Article] Protamine/Plasmid/Anionic Sugar-PEG Ternary Complex as a Novel Receptor-Mediated Gene Delivery System2003
- Author(s)
  Yoshiyuki Koyama
- Journal Title
  
  Molecular Therapy Vol.7
  
  Pages: 244-224
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500324
[Journal Article] Protamine/Plasmid/Anionic Sugar-PEG Ternary Complex as a Novel Receptor-Mediated Gene Delivery System2003
- Author(s)
  Yoshiyuki Koyama
- Journal Title
  
  Molecular Therapy 7
  
  Pages: 224-224
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500324
[Journal Article] Novel poly (ethylene glycol) derivatives with carboxylic acid pendantgroups : synthesis and their protection and enhancing effect on non-viral gene transfection systems2003
- Author(s)
  Yoshiyuki Koyama
- Journal Title
  
  J. Biomater. Sci. Polymer Edn. Vol.14
  
  Pages: 515-531
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500324
[Patent] 免疫治療システム2016
- Inventor(s)
  小山　義之
- Industrial Property Rights Holder
  小山　義之
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-219198
- Filing Date
  2016-10-24
- Data Source
  KAKENHI-PROJECT-16K01394
[Patent] 新規な複合体、それを含有する医薬及び癌の治療方法2011
- Inventor(s)
  小山義之、芳原智恵子
- Industrial Property Rights Holder
  アルファ・ナノ・メディカ(株)
- Industrial Property Number
  2011-201136
- Filing Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-21500430
[Patent] 新規なベクター、それを含有する医薬及び癌の治療方法2010
- Inventor(s)
  濱田雄行、小山義之、芳原智恵子、伊藤智子
- Industrial Property Rights Holder
  アルファ・ナノ・メディカ(株)
- Industrial Property Number
  2010-020766
- Filing Date
  2010-04-20
- Data Source
  KAKENHI-PROJECT-21500430
[Patent] 核酸, オリゴ核酸, 又はその誘導体導入用の凍結乾燥体2006
- Inventor(s)
  小山義之, 伊藤智子
- Industrial Property Rights Holder
  小山義之
- Industrial Property Number
  2006-138201
- Filing Date
  2006-05-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500315
[Presentation] インターフェロン誘導機能を持つアデノウイルス由来の小分子核酸「VA-RNA」の細胞外小胞によるデリバリーとその抗腫瘍効果2023
- Author(s)
  小山義之、溝口出、善本隆之、伊藤　智子
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19K12806
[Presentation] インターフェロン誘導機能を持つアデノウイルス由来の小分子核酸「VA-RNA」の細胞外小胞によるデリバリーとその抗腫瘍効果2023
- Author(s)
  小山義之、溝口出、善本隆之、伊藤智子
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K11854
[Presentation] 微生物感染に学ぶ抗腫瘍免疫遺伝子治療の新戦略2023
- Author(s)
  小山義之、伊藤智子
- Organizer
  遺伝子・デリバリー研究会第21回夏期セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-23K11854
[Presentation] 微生物感染に学ぶ抗腫瘍免疫遺伝子治療の新戦略2023
- Author(s)
  小山義之、伊藤　智子
- Organizer
  遺伝子・デリバリー研究会第21回夏期セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K12806
[Presentation] アデノウイルス由来の小分子核酸「VA-RNA」を内包した細胞外小胞の IFN誘導機能と抗腫瘍効果2022
- Author(s)
  小山義之、伊藤智子、杉浦　喜久弥、善本隆之、溝口出
- Organizer
  日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-19K12806
[Presentation] デノウイルス由来のIFN誘導因子「VA-RNA」を内包した細胞外小胞の調製とその抗腫瘍効果2022
- Author(s)
  小山義之、伊藤智子、善本隆之、溝口出
- Organizer
  遺伝子・デリバリー研究会
- Data Source
  KAKENHI-PROJECT-19K12806
[Presentation] アデノウイルスの免疫活性化機能を模倣した癌免疫治療の新戦略2021
- Author(s)
  小山義之、伊藤智子、善本隆之、溝口出
- Organizer
  遺伝子・デリバリー研究会第２０回シンポジウム
- Data Source
  KAKENHI-PROJECT-19K12806
[Presentation] 疑似感染細胞が分泌する細胞外小胞による免疫誘導機能2021
- Author(s)
  小山義之、伊藤智子、善本隆之、溝口出
- Organizer
  第8回日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-19K12806
[Presentation] 腫瘍溶解性ウイルスを模した癌免疫治療の新戦略2021
- Author(s)
  小山義之、伊藤智子、溝口出、善本隆之、杉浦喜久弥、長谷川綾、大内若菜、稲葉俊夫
- Organizer
  第85回インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-19K12806
[Presentation] 微生物抗原を提示した細胞外小胞の腫瘍免疫治療、感染予防・治療ワクチンへの応用2020
- Author(s)
  小山義之、伊藤智子、江里口正純、善本隆之、溝口出、杉浦喜久弥、長谷川綾、大内若菜、稲葉俊夫
- Organizer
  第7回日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-19K12806
[Presentation] Preparation of "artificial neoepitope"-presenting exosomes and their ability to stimulate antitumor immunity2019
- Author(s)
  Tomoko Ito, Kikuya Sugiura, Aya Hasegawa, Wakana Ouchi, Toshio Inaba, Masazumi Eriguchi, Yoshiyuki Koyama
- Organizer
  遺伝子・デリバリー研究会第１９回シンポジウム
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] エクソソームを用いた抗原提示細胞への結核菌抗原エピトープ／MHC Class I分子複合体の送達とその抗腫瘍免疫誘導効果2019
- Author(s)
  伊藤智子、杉浦喜久弥、大内若菜、長谷川綾、稲葉俊夫、江里口正純、小山義之
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] "Artificial neoantigen"-transfection induced significant inhibition of tumor growth by eliciting innate immunity in the early period in tumor treatment2019
- Author(s)
  Yoshiyuki Koyama, Kikuya Sugiura, Aya Hasegawa, Wakana Ouchi, Toshio Inaba, Masazumi Eriguchi, Tomoko Ito
- Organizer
  遺伝子・デリバリー研究会第１９回シンポジウム
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] Development of "Artificial neoepitope"-presenting exosomes for novel cancer immunotherapy2019
- Author(s)
  Tomoko Ito, Masazumi Eriguchi, Aya Hasegawa, Wakana Ouchi, Toshio Inaba, Kikuya Sugiura, Yoshiyuki Koyama
- Organizer
  European Society of Gene and Cell Therapy 27th annual congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] 「人工ネオエピトープ」を提示したエクソソームを用いたガン免疫治療―免疫治療の新たなブレイクスルーを目指してー2019
- Author(s)
  小山義之
- Organizer
  ヒトと伴侶動物の比較医学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] Antitumour immune activation by "artificial neoantigen"-presenting exosomes derived from the genetically modified cells Wakana Ouchi, Toshio Inaba, Kikuya Sugiura2019
- Author(s)
  Yoshiyuki Koyama, Tomoko Ito, Masazumi Eriguchi, Aya Hasegawa, Wakana Ouchi, Toshio Inaba, Kikuya Sugiura
- Organizer
  European Society of Gene and Cell Therapy 27th annual congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] 「人工ネオエピトープ」提示エクソソームの調製と抗腫瘍ワクチンへの応用2019
- Author(s)
  小山義之、伊藤智子、杉浦喜久弥、大内若菜、長谷川綾、稲葉俊夫、江里口正純
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] Mechanism of antitumor immunity activation by "artificial neoantigen"-presenting exosomes2019
- Author(s)
  Yoshiyuki Koyama, Tomoko Ito, Masazumi Eriguchi, Aya Hasegawa, Wakana Ouchi, Toshio Inaba, Kikuya Sugiura
- Organizer
  ISEV2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] 結核菌抗原を「人工ネオアンティジェン」として提示したエクソソームによる抗腫瘍免疫活性化のメカニズム2019
- Author(s)
  小山義之、伊藤智子、長谷川綾、大内若菜、稲葉俊夫、江里口正純、杉浦喜久弥
- Organizer
  第16回日本免疫治療学研究会学術集会
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] ESAT-6 DNA導入による腫瘍治療効果の免疫組織化学的解析2018
- Author(s)
  大内若菜、牛草貴博、小山義之、伊藤智子、渡邉謙一、James K. CHAMBERS、内田和幸、金城綾二、鳩谷晋吾、稲葉俊夫、杉浦喜久弥
- Organizer
  第161回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] 「人工ネオエピトープ」提示エクソソームによる抗腫瘍免疫活性化のメカニズム2018
- Author(s)
  小山義之、伊藤智子、江里口正純、長谷川綾、大内若菜、稲葉俊夫、杉浦喜久弥
- Organizer
  第5回日本細胞外小胞学会
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] 「人工Neoantigen」遺伝子を導入した細胞由来のエクソソームを用いた抗腫瘍免疫治療2018
- Author(s)
  小山義之、伊藤智子、長谷川綾、杉浦喜久弥、稲葉俊夫、江里口正純
- Organizer
  第15回日本免疫治療学研究会学術集会
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] Artificial neoepitope-presenting exosomes derived from the cells genetically modified to express Mycobacterium tuberculosis antigen as cellular immunity adjuvants2017
- Author(s)
  Tomoko Ito, Kikuya Sugiura, Aya Hasegawa, Toshio Inaba, Masazumi Eriguchi, Yoshiyuki Koyama
- Organizer
  the 25th Anniversary Congress of the European Society for Gene and Cell Therapy
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] 人工Neoantigenによる樹状細胞治療の効果改善2017
- Author(s)
  小山義之、伊藤智子、長谷川綾、杉浦喜久弥、稲葉俊夫、江里口正純
- Organizer
  遺伝子・デリバリー研究会第１７回シンポジウム
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] 「人工Neoantigen」遺伝子を導入した細胞由来のエクソソームを用いた抗腫瘍免疫治療2017
- Author(s)
  小山義之、伊藤智子、長谷川綾、杉浦喜久弥、稲葉俊夫、江里口正純
- Organizer
  第14回日本免疫治療学研究会
- Place of Presentation
  東京大学伊藤国際学術研究センター
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] 「人工ネオエピトープ」提示エクソソームによる樹状細胞の活性化と抗腫瘍効果の向上2017
- Author(s)
  小山義之、伊藤智子、江里口正純、長谷川綾、稲葉俊夫、杉浦喜久弥
- Organizer
  第4回日本細胞外小胞学会
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] 「人工Neoantigen」遺伝子を導入した細胞由来のエクソソームを用いた抗腫瘍免疫治療2017
- Author(s)
  小山義之、伊藤智子、長谷川綾、杉浦喜久弥、稲葉俊夫、江里口正純
- Organizer
  第14回日本免疫治療学研究会学術集会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2017-02-11
- Data Source
  KAKENHI-PROJECT-26350533
[Presentation] Dendritic cell activation induced by Artificial neoepitope-presenting exosomes derived from the genetically modified cells2017
- Author(s)
  Yoshiyuki Koyama, Tomoko Ito, Masazumi Eriguchi, Aya Hasegawa, Toshio Inaba, Kikuya Sugiura
- Organizer
  the 25th Anniversary Congress of the European Society for Gene and Cell Therapy
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] "Artificial neoepitope"- bearing exosomes derived from tumor cells being genetically modified to express Mycobacterium tuberculosis antigen: a novel vaccine for cancer therapy2016
- Author(s)
  Yoshiyuki Koyama, Tomoko Ito, Eriguchi Masazumi, Aya Hasegawa, Toshio Inaba, Kikuya Sugiura
- Organizer
  the 5th Annual Meeting of International Society for Extracellular Vesicles
- Place of Presentation
  De Doelen International Congress Centre, Rotterdam, The Netherlands
- Year and Date
  2016-05-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350533
[Presentation] 人工Neoepitopeを担持したエクソソームを用いた抗腫瘍免疫治療2016
- Author(s)
  小山義之、伊藤智子、長谷川綾、杉浦喜久弥、稲葉俊夫、江里口正純
- Organizer
  遺伝子・デリバリー研究会第16回シンポジウム
- Place of Presentation
  川崎生命科学・環境研究センター（神奈川県川崎市）
- Year and Date
  2016-05-16
- Data Source
  KAKENHI-PROJECT-26350533
[Presentation] 人工Neoantigen（新抗原）遺伝子を用いた抗腫瘍免疫治療システムの創製2016
- Author(s)
  伊藤智子、長谷川綾、牛草貴博、杉浦喜久弥、稲葉俊夫、江里口正純、小山義之
- Organizer
  遺伝子・デリバリー研究会第16回シンポジウム
- Place of Presentation
  川崎生命科学・環境研究センター（神奈川県川崎市）
- Year and Date
  2016-05-16
- Data Source
  KAKENHI-PROJECT-26350533
[Presentation] "Artificial neoepitope"-bearing exosomes as novel vaccine for cancer immunotherapy2016
- Author(s)
  Yoshiyuki Koyama, Tomoko Ito, Kikuya Sugiura, Toshio Inaba
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26350533
[Presentation] 「人工ネオエピトープ」を担持した腫瘍由来エクソソームによるガン免疫治療2016
- Author(s)
  小山義之、伊藤智子、長谷川綾、杉浦喜久弥、稲葉俊夫、江里口正純
- Organizer
  第３回日本細胞外小胞学会
- Place of Presentation
  グランドプリンスホテル広島（広島県広島市）
- Year and Date
  2016-08-30
- Data Source
  KAKENHI-PROJECT-26350533
[Presentation] "Artificial neoepitope"-bearing exosomes as novel vaccine for cancer immunotherapy2016
- Author(s)
  Yoshiyuki Koyama,　Tomoko Ito,　Kikuya Sugiura, Toshio Inaba
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] "Artificial neoepitope"- bearing exosomes derived from tumor cells being genetically modified to express Mycobacterium tuberculosis antigen: a novel vaccine for cancer therapy2016
- Author(s)
  Koyama Yoshiyuki, Ito Tomoko, Eriguchi Masazumi, Hasegawa Aya, Inaba Toshio, Sugiura Kikuya
- Organizer
  5th Annual Meeting of the International Society for Extracellular Vesicles
- Place of Presentation
  Rotterdam, the Netherlands
- Year and Date
  2016-05-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] 「人工ネオエピトープ」を担持した腫瘍由来エクソソームによるガン免疫治療2016
- Author(s)
  小山義之、伊藤智子、長谷川綾、杉浦喜久弥、稲葉俊夫、江里口正純
- Organizer
  第3回日本細胞外小胞学会
- Place of Presentation
  グランドプリンスホテル広島
- Year and Date
  2016-08-31
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] 人工Neoepitopeを担持したエクソソームを用いた抗腫瘍免疫治療2016
- Author(s)
  小山義之、伊藤智子、長谷川綾、杉浦喜久弥、稲葉俊夫、江里口正純
- Organizer
  第１６回遺伝子・デリバリー研究会シンポジウム
- Place of Presentation
  川崎生命科学・環境研究センター
- Data Source
  KAKENHI-PROJECT-16K01394
[Presentation] Tissue-Adhesive Hydrogel for Hemostasis Comprising Water-Swellable Poly(acrylic acid)/Poly(vinylpyrrolidone) Complex2015
- Author(s)
  Yoshiyuki Koyama, Tomoko Ito, Shingo Yamaguchi, Yoichi Kurachi, Masazumi Eriguchi
- Organizer
  European Society for Biomaterials
- Place of Presentation
  ICE Krakow Congress Centre, Cracow, Poland
- Year and Date
  2015-08-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350555
[Presentation] Preparation and therapeutic effect of calcium phosphate nano-capsules enclosing DNA/PEI/hyaluronic acid complex for durable gene expression2015
- Author(s)
  Tomoko Ito, Yoshiyuki Koyama, Masazumi Eriguchi, Makoto Otsuka
- Organizer
  27th European Conference on Biomaterials
- Place of Presentation
  Kraków (POLAND)
- Year and Date
  2015-08-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350533
[Presentation] 結核菌抗原遺伝子を用いた新規抗腫瘍DNAワクチンの創製2015
- Author(s)
  伊藤智子、牛草貴博、杉浦喜久弥、稲葉俊夫、江里口正純、小山義之
- Organizer
  日本バイオマテリアル学会
- Place of Presentation
  京都テルサ、京都市
- Year and Date
  2015-11-09
- Data Source
  KAKENHI-PROJECT-25350555
[Presentation] DNA complex release system by injectable auto-forming alginate gel including amorphous calcium phosphate2015
- Author(s)
  Tomoko Ito, Yoshiyuki Koyama
- Organizer
  the 2015 Society For Biomaterials Annual Meeting & Exposition
- Place of Presentation
  North Carolina (USA)
- Year and Date
  2015-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350533
[Presentation] DNA complex release system by injectable auto-forming alginate gel including amorphous calcium phosphate2015
- Author(s)
  Tomoko Ito, Yoshiyuki Koyama
- Organizer
  Society For Biomaterials
- Place of Presentation
  the Charlotte Convention Center, Charlotte. NC，U SA
- Year and Date
  2015-04-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350555
[Presentation] 結核菌抗原遺伝子を用いた新規抗腫瘍DNAワクチンの創製2015
- Author(s)
  伊藤智子、牛草貴博、杉浦喜久弥、稲葉俊夫、江里口正純、小山義之
- Organizer
  第37回日本バイオマテリアル学会大会
- Place of Presentation
  京都テルサ（京都・京都）
- Year and Date
  2015-11-09
- Data Source
  KAKENHI-PROJECT-26350533
[Presentation] 微生物抗原遺伝子導入による抗腫瘍免疫の亢進2013
- Author(s)
  芳原智恵子、伊藤智子、牛草貴博、小山義之
- Organizer
  第13回遺伝子・デリバリーシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Evaluation by the electron microscope of the oncolytic adenovirus by polymer multiplex processing treatment2013
- Author(s)
  Takagi Kazuko、Hamada Katsuyuki,、Tomoko Ito、Chieko Yoshihara、Yoshiyuki Koyama
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 結核菌抗原遺伝子をコードしたプラスミド複合体の調製と癌治療効果2013
- Author(s)
  芳原智恵子、小山義之
- Organizer
  第29回日本DDS学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 腫瘍細胞への結核菌抗原遺伝子導入による抗腫瘍免疫治療効果2013
- Author(s)
  芳原智恵子、小山義之
- Organizer
  第29回日本DDS学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Novel strategy for tumor immunotherapy with a transfection of plasmid encoding pathogenic antigens2013
- Author(s)
  芳原智恵子、伊藤智子、牛草貴博、小山義之
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] プロタミン／ヒアルロン酸高分子イオン複合体を用いたサイトカイン徐放システムの創成2012
- Author(s)
  芳原智恵子、伊藤智子、黒田美奈子、江里口正純、小山義之
- Organizer
  第28回日本DDS学会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Novel Antitumor Strategy by Transfection of Plasmids Encoding Pathogenic Antigen-and Cytokine-Genes2012
- Author(s)
  Y. Koyama, C. Yoshihara, T. Ito, and M. Eriguchi
- Organizer
  American Society of Gene and Cell Therapy
- Place of Presentation
  Philadelphia
- Data Source
  KAKENHI-PROJECT-21500430
[Presentation] Novel Antitumor Strategy by Transfection of Plasmids Encoding Pathogenic Antigen- and Cytokine-Genes2012
- Author(s)
  Yoshiyuki Koyama, Chieko Yoshihara, Tomoko Ito, and Masazumi Eriguchi
- Organizer
  American Society of Gene & Cell Therapy　15th Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 結核菌抗原遺伝子をコードしたプラスミド複合体の調製と動物臨床の応用2012
- Author(s)
  芳原智恵子、伊藤智子、牛草貴博, Min Chai,小山義之
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2012
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 結核菌抗原タンパク遺伝子を用いた免疫治療－免疫賦活化機能とガン治療への応用－2012
- Author(s)
  小山義之、芳原智恵子、伊藤智子
- Organizer
  第87回結核病学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 微生物抗原遺伝子を用いた新しい癌治療の試み2011
- Author(s)
  芳原智恵子、黒田美奈子、小山義之
- Organizer
  第33回バイオマテリアル学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Novel Adenovirus Complexes Having Artificial Envelope For Tumor Gene Therapy2011
- Author(s)
  小山義之、芳原智恵子、濱田雄行
- Organizer
  第17回日本遺伝子治療学会年次学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Oncolytic Plasmid System, a Novel Antitumor Strategy by Plasmid Encoding Adenovirus Protein2011
- Author(s)
  Yoshiyuki Koyama, Chieko Yoshihara, Masahiko Tojyo, Tomoko Ito, Katsuyuki Hamada
- Organizer
  American Society of Gene & Cell Therapy 14th Annual Meeting
- Place of Presentation
  Seattle, Washington,USA
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 高分子イオン複合体を用いたサイトカイン徐放デバイスの創製とその抗腫瘍効果2011
- Author(s)
  黒田美奈子、芳原智恵子、小山義之
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] ウィルス抗原遺伝子を用いたガン免疫治療の新しい考えかた2011
- Author(s)
  小山義之、芳原智恵子、黒田美奈子、濱田雄行
- Organizer
  第21回バイオ・高分子シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 微生物抗原遺伝子を用いた腫瘍免疫遺伝子治療システムの開発2011
- Author(s)
  芳原智恵子, 黒田美奈子, 東條雅彦, 小山義之
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム 2011
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Highly Effective Non-viral Antitumor Gene Therapy System Comprising Biocompatible Small Plasmid Complex Particles2011
- Author(s)
  Chieko Yoshihara, Tomoko Ito, Yoshiyuki Koyama
- Organizer
  American Society of Gene & Cell Therapy 14th Annual Meeting
- Place of Presentation
  Seattle, Washington,USA
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Oncolytic Plasmid System, a Novel Antitumor Strategy by Plasmid Encoding Adenovirus Protein2011
- Author(s)
  Y. Koyama, M. Tojyo, C. Yoshihara, K. Hamada, and T. Ito
- Organizer
  American Society of Gene and Cell Therapy
- Place of Presentation
  Seattle
- Data Source
  KAKENHI-PROJECT-21500430
[Presentation] Oncolytic Plasmid System, a Novel Antitumor Strategy by Plasmid Encoding Adenovirus Protein2011
- Author(s)
  Yoshiyuki Koyama, 他
- Organizer
  American Society of Gene Therapy
- Place of Presentation
  Seattle, Washington, USA
- Data Source
  KAKENHI-PROJECT-21500430
[Presentation] 微生物抗原遺伝子を用いた腫瘍免疫遺伝子治療システムの開発2011
- Author(s)
  芳原智恵子, 黒田美奈子, 東條雅彦, 小山義之
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2011
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 微生物抗原遺伝子によるがん治療2011
- Author(s)
  小山義之、黒田美奈子、芳原智恵子
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] 高分子イオン複合体を用いたサイトカイン徐放システムの開発2011
- Author(s)
  黒田美奈子、芳原智恵子、小山義之
- Organizer
  第33回バイオマテリアル学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Oncolytic Plasmid, A Novel Antitumor Strategy With Plasmid Encoding adenovirus Protein2011
- Author(s)
  小山義之、芳原智恵子、黒田美奈子、東條雅彦、濱田雄行
- Organizer
  第17回日本遺伝子治療学会年次学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Preparation Of Small Plasmid Complex For Cancer Therapy And Application To Medium Animal Clinical Study2011
- Author(s)
  芳原智恵子、小山義之、伊藤智子、岡野正三
- Organizer
  第17回日本遺伝子治療学会年次学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23701103
[Presentation] Small Plasmid/PEI/Anionic Polysaccharide Ternary Complex Particles : Toxicity and Animal Clinical Study2010
- Author(s)
  Y.Koyama, et.al.
- Organizer
  American Society of Gene Therapy
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-21500430
[Presentation] Small Plasmid/PEI/Anionic Polysaccharide Ternary Complex Particles : Toxicity and Animal Clinical Study2010
- Author(s)
  Y. Koyama, M. Tojyo, C. Yoshihara, K. Hamada, and T. Ito
- Organizer
  American Society of Gene and Cell Therapy
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-21500430
[Presentation] Analysis of the surface structure of DNA/polycation/hyaluronic acid ternary complex by Raman microscopy2009
- Author(s)
  T. Ito, Y. Koyama, M. Otsuka
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura (CA), USA
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] 極微細なプラスミド複合体の調製とその治療効果2009
- Author(s)
  小山義之, 濱田雄行, 伊藤智子, 芳原智恵子
- Organizer
  アンチセンスシンポジウム
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] Improve of transcription-and transfection efficiency by synthetic polyampholytes2009
- Author(s)
  C. Yoshihara, T. Ito, C. -Y. Shew, Y, Koyama
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura (CA), USA
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] Preparation of Very Small Plasmid Complex Particles and Their Therapeutic Effects against Cancer2009
- Author(s)
  Y. Koyama, C. Yoshihara, K. Hamada, T. Ito
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura (CA), USA
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] Improve of transcription-and transfection efficiency by synthetic polyampholytes2009
- Author(s)
  polyampholytes, C. Yoshihara, T. Ito, C.-Y. Shew, Y. Koyama
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura (CA)
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] Preparation of Very Small Plasmid Complex Particles and Their Therapeutic Effects against Cancer2009
- Author(s)
  Y. Koyama, C. Yoshihara, K. Hamada, T. Ito
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura (CA)
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] Analysis of the surface structure of DNA/polycation/hyaluronic acid ternary complex by Raman microscopy2009
- Author(s)
  T. Ito, Y. Koyama, M. Otsuka
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura (CA)
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] DNA/ポリカチオン/両性イオン高分子三元複合体の調製条件と転写活性との相関2009
- Author(s)
  芳原智恵子, C.-Y. Shew, 小山義之
- Organizer
  アンチセンスシンポジウム
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] DNA/ポリカチオン/ポリアニオン/両性イオン型高分子四元複合体による高発現遺伝子導入システム2008
- Author(s)
  芳原智恵子, 伊藤智子, 小山義之
- Organizer
  第24回日本DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] DNA/ポリカチオン/ポリアニオン/両性イオン型高分子四元複合体による高発現遺伝子導入システム2008
- Author(s)
  芳原智恵子, 伊藤智子, 小山義之
- Organizer
  第24回DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] 極微細なプラスミド複合体の調製とその治癒効果2008
- Author(s)
  小山義之, 濱田雄行, 伊藤智子, 芳原智恵
- Organizer
  第24回DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] レーザーラマン顕微鏡によるDNA/ポリカチオン/ヒアルロン酸三元複合体の表面構造解析2008
- Author(s)
  伊藤智子, 小山義之, 大塚誠
- Organizer
  日本バイオマテリアル学会シンポジウム2008
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] 合成両イオン型高分子による転写・翻訳促進機構2008
- Author(s)
  芳原智恵子, 伊藤智子, 小山義之
- Organizer
  第9回遺伝子・デリバリー研究会シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] DNA/ポリカチオン/両性イオン高分子三元複合体の調製条件と転写活性との相関2008
- Author(s)
  芳原智恵子, C. -Y. Shew, 小山義之
- Organizer
  アンチセンスシンポジウム
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] 極微細なプラスミド複合体の調製とその治癒効果2008
- Author(s)
  小山義之, 濱田雄行, 伊藤智子, 芳原智恵子
- Organizer
  第24回日本DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] Improve of transcription- and transfection-efficiency by synthetic polyampholytes2008
- Author(s)
  C. Yoshihara, T. Ito, C.-Y. Shew, Y. Koyama
- Organizer
  国際核酸シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] Preparation of Fine DNA Particles and High Level Tumor-targeted In Vivo Gene Expression after Intravenous Injection2008
- Author(s)
  Injection, T. Ito, M. Otsuka, Y. Koyama
- Organizer
  アメリカ遺伝子治療学会
- Place of Presentation
  Boston (MA)
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] 極微細なプラスミド複合体の調製とその治療効果2008
- Author(s)
  小山義之, 清田雄行, 伊藤智子, 芳原智恵子
- Organizer
  アンチセンスシンポジウム
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] In Vivo Efficient Gene Expression by Freeze-Dried DNA Complexes Coated by Polyanions2007
- Author(s)
  Tomoko Ito, Keiko Abe, Naoko Iida-Tanaka, Yoshiyuki Koyama
- Organizer
  American Society of Gene Therapy
- Place of Presentation
  シアトル、アメリカ合衆国
- Year and Date
  2007-06-02
- Data Source
  KAKENHI-PROJECT-19510119
[Presentation] Development and Therapeutic Efficacy of the DNA Complex-Releasing Systems Comprising Injectable Auto-Forming Alginate Gel
- Author(s)
  Tomoko Ito, Yoshiyuki Koyama
- Organizer
  European Society for Gene and Cell Therapy
- Place of Presentation
  The Hague, The Netherlands
- Year and Date
  2014-10-23 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-25350555
[Presentation] Oncolytic Plasmid System; a Novel Antitumor Strategy by Plasmids Encoding Pathogenic Antigens Blocking the Immune Escape of Tumor
- Author(s)
  Yoshiyuki Koyama, Takahiro Ushigusa, Toshio Inaba, Kikuya Sugiura, Masazumi Eriguchi, Tomoko Ito
- Organizer
  ESGCT and NVGCT Collaborative Congress
- Place of Presentation
  World Forum, The Hague, Netherlands
- Year and Date
  2014-10-23 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-26350533
[Presentation] Oncolytic Plasmid System; a Novel Antitumor Strategy by Plasmids Encoding Pathogenic Antigens Blocking the Immune Escape of Tumor
- Author(s)
  Yoshiyuki Koyama, Takahiro Ushigusa, Toshio Inaba, Kikuya Sugiura, Masazumi Eriguchi, Tomoko Ito
- Organizer
  European Society for Gene and Cell Therapy
- Place of Presentation
  The Hague, The Netherlands
- Year and Date
  2014-10-23 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-25350555
[Presentation] Novel Adhesive Hemostatic Sponges Comprising PAA/PVP Gel: Preparation and Clinical Application in Dental Surgery
- Author(s)
  Yoshiyuki Koyama, Shingo Yamaguchi, Yoichi Kurachi, Masazumi Eriguchi, Tomoko Ito
- Organizer
  European Society for Biomaterials
- Place of Presentation
  Liverpool, UK
- Year and Date
  2014-08-31 – 2014-09-03
- Data Source
  KAKENHI-PROJECT-25350555
[Presentation] Development of novel biodegradable device forming bioadhesive hydrogel for Hemostatics and adhesion barriers (2): Preparation of the Hemostatic Sponges and Clinical Application in Dental Surgery
- Author(s)
  Yoshiyuki Koyama, Tomoko Ito, Shingo Yamaguchi, Yoichi Kurachi, Masazumi Eriguchi
- Organizer
  Society For Biomaterials
- Place of Presentation
  Denver, CO, USA
- Year and Date
  2014-04-16 – 2014-04-19
- Data Source
  KAKENHI-PROJECT-25350555
[Presentation] DNA complex release system by injectable auto-forming alginate gel including amorphous calcium phosphate
- Author(s)
  Tomoko Ito, Yoshiyuki Koyama
- Organizer
  Society For Biomaterials
- Place of Presentation
  Charlotte, NC, USA
- Year and Date
  2015-04-15 – 2015-04-18
- Data Source
  KAKENHI-PROJECT-25350555
[Presentation] Development and Therapeutic Efficacy of the DNA Complex-Releasing Systems Comprising Injectable Auto-Forming Alginate Gel
- Author(s)
  Tomoko Ito, Yoshiyuki Koyama
- Organizer
  ESGCT and NVGCT Collaborative Congress
- Place of Presentation
  World Forum, The Hague, Netherlands
- Year and Date
  2014-10-23 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-26350533
[Presentation] 生分解性生体接着材料の開発と止血材・癒着防止材への応用
- Author(s)
  小山義之、江里口正純、伊藤智子
- Organizer
  日本高分子学会高分子討論会
- Place of Presentation
  長崎大学文教キャンパス
- Year and Date
  2014-09-24 – 2014-09-26
- Data Source
  KAKENHI-PROJECT-25350555
[Presentation] 生分解性生体接着材料の開発と止血材・癒着防止材への応用
- Author(s)
  小山義之、江里口正純、伊藤智子
- Organizer
  第63回高分子討論会
- Place of Presentation
  長崎大学文教キャンパス
- Year and Date
  2014-09-24 – 2014-09-26
- Data Source
  KAKENHI-PROJECT-26350533

1. YOSHIHARA Chieko (40597093)

# of Collaborated Projects: 3 results

# of Collaborated Products: 35 results
2. KURITA Keisuke (30102180)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. YANAGIE Hironobu (30212278)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Ito Tomoko (80372910)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
5. TANI Kenzaburo (00183864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MARUYAMA Kazuo (30130040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KONO Kenji (90215187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAMAI Ikumi (20155237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TANAKA Naoko (40184353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMASHITA Misa (00458720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Hamada Katsuyuki (90172973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 打出毅 (20327456)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 古谷哲也 (60647676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 杉山隆 (10263005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 高木哲 (50396305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ERIGUCHI Masazumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
17. USHIGUSA Takahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
18. 山本真紀子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 杉浦喜久弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOYAMA Yoshiyuki 小山 義之

小山 義之 コヤマ ヨシユキ

Research Projects

Research Products

Co-Researchers

微生物遺伝子を導入した疑似感染細胞が分泌する細胞外小胞による抗腫瘍免疫治療の創製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel strategy of anti-tumor immune therapy using pseudo-infection exosomes presenting artificial neoepitopesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Preclinical efficacy study of novel carrier cells for refractory solid tumors in companion animals

Principal Investigator

Project Period (FY)

Research Category

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A novel strategy for a cancer immunotherapy and infectious disease treatment using microbial antigen-presenting exosomesPrincipal Investigator

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Novel DNA vaccine strategy to elicit antitumor immune responses by transfecting with plasmids coding for pathogenic antigens

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Development of Novel Antitumor DNA Vaccine Utilizing a Plasmid Expressing a Mycobacterium Tuberculosis AntigenPrincipal Investigator

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PREPARATION OF SMALL PLASMID COMPLEX FOR CANCER THERAPY AND APPLICATION TO MEDIUM ANIMAL CLINICAL STUDY

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Novel Strategy of Tumor Gene Therapy by Very Small Plasmid Complex ParticlesPrincipal Investigator

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Preparation of the lyophilizable DNA complexes and novel therapeutic system with the freeze-dried solid complexesPrincipal Investigator

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Bio-compatible gene-delivery systems with transcriptional-enhancing functionPrincipal Investigator

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Development of Gene Therapy with Nanotechnology derived Intelligent Drug Deliver Systems

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Cell Specific Gene Delivery Systems with DNA Complexes Coated by Sugar-bearing PolyanionsPrincipal Investigator

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糖鎖を表面に持つ高分子会合体の調製とその細胞との相互作用Principal Investigator

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KOYAMA Yoshiyuki 小山義之

小山義之コヤマヨシユキ