Hirano Tsutomu 平野勉

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HIRANO Tsutomu 平野勉

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Researcher Number	00167610
Affiliation (Current)	2025: 昭和大学, 医学部, 名誉教授
Affiliation (based on the past Project Information) *help	2012: 昭和大学, 医学部, 教授 2010: 昭和大学, 医学部, 教授 2006 – 2008: 昭和大学, 医学部, 教授 2002 – 2003: 昭和大学, 医学部, 助教授 2000: 昭和大, 医学部, 助教授 1999 – 2000: 昭和大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Metabolomics Except Principal Investigator Circulatory organs internal medicine / Metabolomics
Keywords	Principal Investigator Insulin resistance / LPL deficiency / pre heparin plasma / lipoprotein lipase / トリグリセライド / LPL欠損症 / インスリン抵抗性 / リポ蛋白リパーゼ / Diabetes / Hypertriglyceridemia … More / Apo CIII / Apo CI / マウス / 糖尿病性腎症 / アポE / レムナント / アポC3 / アポCl / 糖尿病 / 高トリグリセライド血症 / アポCIII / アポCI … More Except Principal Investigator マクロファージ / 動脈硬化 / サリューシン / 高血圧 / 血管作動性物質 / Macrophage Foam Cell Formation / Salusin / Urotensin ll / Complications / Atherosclerosis / Hypertension / Vasoactive Agents / 高血圧合併症 / マクロファージ泡沫化 / ウロテンシンII / 合併症 / ACAT-1 / CD36 / 泡沫化 / マクロファージの泡沫化 / 糖尿病 / DPP-4阻害剤 / インクレチン / 分子血管病態学 / 酵素 / コレステロール / 蛋白質 / 接着分子 / 内皮細胞 / 単球 Less

Therapeutic Strategy of Diabetic Macroangiopathy using the Gut Hormone Incretin
- Principal Investigator
  
  WATANABE Takuya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo University of Pharmacy and Life Science
Regulation of macrophage foam cell formation and atherosclerosis by novel regulatory peptides for cardiovascular system
- Principal Investigator
  
  MIYAZAKI Akira
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Showa University
Mechanisms of Macrophage Foam Cell Formation and Hypertensive Complications Caused by Vasoactive Agents
- Principal Investigator
  
  WATANABE Takuya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Showa University
Clinical significance of preheparin lipoprotein lipase massPrincipal Investigator
- Principal Investigator
  
  HIRANO Tsutomu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Showa University
Physiological and clinical significance of apolipoprotein CIPrincipal Investigator
- Principal Investigator
  
  HIRANO Tsutomu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  SHOWA UNIVERSITY

All 2011 2010 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Chronic infusion of salusin-α and-β exerts opposite effects on macrophage foam cell formation and atherosclerosis in apolipoprotein E-deficient mice.2010
- Author(s)
  Nagashima M, Watanabe T, Hirano T, et al.
- Journal Title
  
  Atherosclerosis
  
  Volume: 212 Pages: 70-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590831
[Journal Article] Chronic infusin of salusin-α and salusin-β exerts opposite effects on atherosclerostic lesion development in apolipoprotein E-deficient mice.2010
- Author(s)
  Nagashima M, Watanabe T, Shiraishi Y, Morita R, Terasaki M, Arita S, Hongo S, Sato K, Shichiri M, Miyazaki A, Hirano T
- Journal Title
  
  Atherosclerosis 212(1)
  
  Pages: 70-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591084
[Journal Article] Ezetimibe decreases serum amyloid A levels in HDL3 in hemodialysis patients.2010
- Author(s)
  Hirano T, Watanabe T, et al.
- Journal Title
  
  Clinical Nephrology
  
  Volume: 74 Pages: 282-287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590831
[Journal Article] インクレチン関連薬の糖代謝以外の作用効果2010
- Author(s)
  長嶋理晴、渡部琢也、平野勉
- Journal Title
  
  診断と治療
  
  Volume: 98 Pages: 415-421
- Data Source
  KAKENHI-PROJECT-22590831
[Journal Article] 糖尿病治療を変える新たな糖尿病薬インクレチン2010
- Author(s)
  李相翔、長嶋理晴、平野勉、渡部琢也
- Journal Title
  
  昭和医学会雑誌
  
  Volume: 70 Pages: 34-44
- NAID
  130000852880
- Data Source
  KAKENHI-PROJECT-22590831
[Journal Article] Increased plasma urotensin-II and carotid atherosclerosis are associated with vascular dementia.2009
- Author(s)
  Ban Y, Watanabe T, Suguro T, Matsuyama T, Iso Y, Sakai T, Sato R, Idei T, Nakano Y, Ota H, Miyazaki A, Kato N, Hirano T, Ban Y, Kobayashi Y
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis 16(3)
  
  Pages: 179-187
- NAID
  10025765398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591084
[Journal Article] Preventive effects of heregulin-β1 on macrophage foam cell formation and atherosclerosis.2009
- Author(s)
  Xu G, Watanabe T, Iso Y, Koba S, Sakai T, Nagashima M, Arita S, Hongo S, Ota H, Kobayashi Y, Miyazaki A, Hirano T
- Journal Title
  
  Circulation Research 105(5)
  
  Pages: 500-510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591084
[Journal Article] Increased plasma urotensin-II levels are associated with diabetic retinopathy and carotid atherosclerosis in type 2 diabetes mellitus.2008
- Author(s)
  Suguro T, Watanabe T, Kodate S, Xu G, Hirano T, Adachi M, Miyazaki A
- Journal Title
  
  Clinical Science 115(11)
  
  Pages: 327-334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591084
[Journal Article] Chronic urotensin II infusion enhances macrophage foam cell formation and atherosclerosis in apolipoprotein E-knockout mice.2008
- Author(s)
  Shiraishi Y, Watanabe T, Suguro T, Kato R, Hongo S, Itabe H, Miyazaki A, Hirano T, Adachi M
- Journal Title
  
  Journal of Hypertension 26(10)
  
  Pages: 1955-1965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591084
[Journal Article] Increased human urotensin II levels are correlated with carotid atherosclerosis in essential hypertension2007
- Author(s)
  Suguro, T., Watanabe, T., Hirano, T., Miyazaki, A., et. al.
- Journal Title
  
  Am J Hypertens 20
  
  Pages: 211-217
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590824
[Journal Article] Increased human urotensin II levels are correlated with carotid atherosclerosis in essential hypertension2007
- Author(s)
  Suguro T, Watanabe T, Hirano T, Miyazaki A, et. al.
- Journal Title
  
  Am J Hypertens 20
  
  Pages: 211-217
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590824
[Journal Article] Angiotensin II infusion decreases plasma adiponectin level via its type 1 receptor in rats : an implication for hypertension-related insulin resistance.2006
- Author(s)
  Ran J, Hirano T, et al.
- Journal Title
  
  Metabolism 55
  
  Pages: 478-478
- Data Source
  KAKENHI-PROJECT-18590824
[Journal Article] Opposing actions of angiotensin II type 1 and 2 receptors on plasma cholesterol levels in rats.2006
- Author(s)
  Hirano T, et al.
- Journal Title
  
  J Hypertyens 24
  
  Pages: 103-108
- Data Source
  KAKENHI-PROJECT-18590824
[Presentation] Native incretins suppress the proliferation and migration of vascular smooth muscle cells2011
- Author(s)
  Tomoyasu M, Nagashima M, Watanabe T,Hirano T, et al
- Organizer
  3rd Scientific Meeting of the Asian Association for the Study of Diabetes
- Place of Presentation
  Beijing, China
- Year and Date
  2011-07-23
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] Glucose-dependent insulinotropic polypeptide suppresses the development of atherosclerosis in apolipoprotein E-null mice via its own receptors2011
- Author(s)
  Terasaki M, Nagashima M, Watanabe T,Hirano T, et al
- Organizer
  第43回日本動脈硬化学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-07-15
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] DPP-4阻害剤はアポEノックアウトマウスの動脈硬化進展を抑制する2011
- Author(s)
  寺崎道重、長嶋理晴、平野勉、渡部琢也
- Organizer
  第58回昭和医学会総会
- Place of Presentation
  東京
- Year and Date
  2011-11-26
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] GIPの慢性持続投与はApoE 欠損マウスの動脈硬化進展を抑制する2011
- Author(s)
  長嶋理晴、渡部琢也、平野勉
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] Preventive effects of heregulin-β1 on macrophage foam cell formation and atherosclerosis.2010
- Author(s)
  渡部琢也・有田茂子・長嶋理晴・平野勉・宮崎章・他
- Organizer
  第42回日本動脈硬化学会学術集会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-20591084
[Presentation] Incretin-based treatments prevent the development of atherosclerotic lesions in apolipoprotein E-null mice2010
- Author(s)
  Watanabe T, Nagashima M, Hirano T, et al
- Organizer
  83rd Scientific Sessions of the American Heart Association
- Place of Presentation
  Chicago, Illinois, USA
- Year and Date
  2010-10-17
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] Incretins prevent the development of atherosclerosis in apolipoprotein E-null mice.2010
- Author(s)
  長嶋理晴、寺崎道重、渡部琢也、平野勉
- Organizer
  第42回日本動脈硬化学会学術集会
- Place of Presentation
  岐阜
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] Incretins prevent the development of atherosclerosis in apolipoprotein E-null mice2010
- Author(s)
  長嶋理晴、渡部琢也、平野勉
- Organizer
  第42回日本動脈硬化学会学術集会
- Place of Presentation
  岐阜
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] Incretins directly suppress the development papolipoprotein E-null mice of macrophage-driven atherosclerosis in apolipoprotein E-null mice2010
- Author(s)
  Hirano T, Nagashima M, Watanabe T, et al.
- Organizer
  46th Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] Incretins directly suppress the development of macrophage-driven atherosclerosis in apolipoprotein E-null mice2010
- Author(s)
  Hirano T, Nagashima M, Watanabe T, et al
- Organizer
  46th Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] Incretins prevent the development of atherosclerosis in apolipoprotein E-null mice2010
- Author(s)
  Nagashima M, Watanabe T, Hirano T, et al
- Organizer
  70th Scientific Sessions of the American Diabetes Association
- Place of Presentation
  Orland, Florida, USA
- Year and Date
  2010-06-29
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] Incretin-based treatments prevent the development of atherosclerotic lesions in apolipoprotein E-null mice.2010
- Author(s)
  Watanabe T, Nagashima M, Hirano T, et al.
- Organizer
  83rd Scientific Sessions of the American Heart Association
- Place of Presentation
  Chicago, Illinois, USA
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] Incretins prevent the development of atherosclerosis in apolipoprotein E-null mice2010
- Author(s)
  Nagashima M, Watanabe T, Hirano T, et al
- Organizer
  Asia Lslet Biology & Incretin Symposium
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2010-07-31
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] ApoE欠損マウスにおけるGLP-1の持続投与が動脈硬化に及ぼす影響2010
- Author(s)
  長嶋理晴、渡部琢也、平野勉
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] Incretins prevent the development of atherosclerosis in apolipoprotein E-null mice.2010
- Author(s)
  Nagashima M, Watanabe T, Hirano T, et al.
- Organizer
  70th Scientific Sessions of the American Diabetes Association
- Place of Presentation
  Orland, Florida, USA
- Year and Date
  2010-06-29
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] Incretins prevent the development of atherosclerosis in apolipoprotein E-null mice.2010
- Author(s)
  Nagashima M, Watanabe T, Hirano T, et al.
- Organizer
  Asia Lslet Biology & Incretin Symposium
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2010-07-31
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] Preventive effects of heregulin-β1, a nerve growth factor, on macrophage foam cell formation and atherosclerosis2010
- Author(s)
  渡部琢也、平野勉, 他
- Organizer
  第42回日本動脈硬化学会学術集会
- Place of Presentation
  岐阜
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-22590831
[Presentation] Chronic infusion of salusin-α and -β exerts opposite effects on atherosclerotic lesion development in apolipoprotein E-knockout mice.2009
- Author(s)
  長嶋理晴・渡部琢也・宮崎章・平野勉
- Organizer
  第41回日本動脈硬化学会学術集会
- Place of Presentation
  下関
- Data Source
  KAKENHI-PROJECT-20591084
[Presentation] Opposite effects of salusins on the development of atherosclerotic plaques.2009
- Author(s)
  Watanabe T, Nagashima M, Arita S, Hongo S, Shichiri M, Hirano T, Miyazaki A
- Organizer
  American Heart Association Scientific Sessions 2009
- Place of Presentation
  Orlando
- Data Source
  KAKENHI-PROJECT-20591084
[Presentation] 血漿ウロテンシンII(UII)濃度の増加と糖尿病性網膜症との関連2008
- Author(s)
  勝呂俊昭・渡部琢也・宮崎章・平野勉・他
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591084
[Presentation] 血漿ウロテンシンII(UII)濃度の増加と糖尿病性網膜症および頸動脈硬化との関連2008
- Author(s)
  勝呂俊昭・渡部琢也・宮崎章・平野勉, 他
- Organizer
  第40回日本動脈硬化学会学術集会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-20591084
[Presentation] Increased human urotensin II levels are correlated with carotid atherosclerosis in 〓2006
- Author(s)
  Suguro, T., Watanabe, T., Hirano, T., Miyazaki, A., et. al.
- Organizer
  American Heart Association Scientific Sessions 2006
- Place of Presentation
  Chicago, Illinois, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590824

1. WATANABE Takuya (30297014)

# of Collaborated Projects: 3 results

# of Collaborated Products: 33 results
2. MIYAZAKI Akira (70253721)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. SHICHIRI Masayoshi (10206097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. KOBA Shinji (20276546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAGASHIMA Masaharu (20468606)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
6. 鹿目知子 (70420908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hirano Tsutomu 平野 勉

HIRANO Tsutomu 平野 勉

Research Projects

Research Products

Co-Researchers

Therapeutic Strategy of Diabetic Macroangiopathy using the Gut Hormone Incretin

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of macrophage foam cell formation and atherosclerosis by novel regulatory peptides for cardiovascular system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of Macrophage Foam Cell Formation and Hypertensive Complications Caused by Vasoactive Agents

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical significance of preheparin lipoprotein lipase massPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Physiological and clinical significance of apolipoprotein CIPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Chronic infusion of salusin-α and-β exerts opposite effects on macrophage foam cell formation and atherosclerosis in apolipoprotein E-deficient mice.2010

Author(s)

Journal Title

Data Source

[Journal Article] Chronic infusin of salusin-α and salusin-β exerts opposite effects on atherosclerostic lesion development in apolipoprotein E-deficient mice.2010

Author(s)

Journal Title

Data Source

[Journal Article] Ezetimibe decreases serum amyloid A levels in HDL3 in hemodialysis patients.2010

Author(s)

Journal Title

Data Source

[Journal Article] インクレチン関連薬の糖代謝以外の作用効果2010

Author(s)

Journal Title

Data Source

[Journal Article] 糖尿病治療を変える新たな糖尿病薬インクレチン2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Increased plasma urotensin-II and carotid atherosclerosis are associated with vascular dementia.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Preventive effects of heregulin-β1 on macrophage foam cell formation and atherosclerosis.2009

Author(s)

Journal Title

Data Source

[Journal Article] Increased plasma urotensin-II levels are associated with diabetic retinopathy and carotid atherosclerosis in type 2 diabetes mellitus.2008

Author(s)

Journal Title

Data Source

[Journal Article] Chronic urotensin II infusion enhances macrophage foam cell formation and atherosclerosis in apolipoprotein E-knockout mice.2008

Author(s)

Journal Title

Data Source

[Journal Article] Increased human urotensin II levels are correlated with carotid atherosclerosis in essential hypertension2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Increased human urotensin II levels are correlated with carotid atherosclerosis in essential hypertension2007

Author(s)

Hirano Tsutomu 平野勉

HIRANO Tsutomu 平野勉