OSANAI Tomohiro 長内智宏

… Alternative Names

Researcher Number	00169278
Other IDs
Affiliation *help	2015 – 2018 : 弘前大学, 保健学研究科, 教授 2011 – 2014 : 弘前大学, 医学(系)研究科(研究院), 准教授 2014 : 弘前大学, 医学研究科, 准教授 2013 : 弘前大学, 大学院医学研究科, 准教授 2007 – 2011 : Hirosaki University, Graduate School of Medicine, Associate Professor 2001 – 2006 : 弘前大学, 医学部, 助教授 1997 : 弘前大学, 医学部・附属病院, 講師
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine / Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Circulatory organs internal medicine / Cardiovascular medicine
Keywords	Principal Investigator coupling factor 6 / prostacyclin / mitochondria / Coupling factor 6 / intracellular acidosis / Vasoconstrictor / acidosis / Prostacyclin / Mitochondria / Hypertension … More Except Principal Investigator P122蛋白 / Phospholipase C / 循環器・高血圧 / phospholipase C / 冠攣縮 / Phospholipase C-δ1 / phospholipase C-δ1 / coronary spastic angina / R257H亜型PLC-δ1 / 冠攣縮性狭心症 / Rho A / phosphoｌipase C / SERCA2 / p122 protein / transgenic mouse / 皮膚線維芽細胞 / small G蛋白 / Exercise / transverse aortic constriction / 血管平滑筋細胞 / heart failure / Acethylcholine / Dhospholipase C / UCG / Acidosis / Vasospastic angina / Intracellular calcium / 冠孿縮 / exercise / small G protein / vascular smooth muscle / skin fibroblast / Coupling factor 6 / intracellular Ca ion / Salt / pressure overload / Phospholamban / P122 protein / Transgenic mouse / hypertrophy / 細胞内カルシウムイオン / Hypertension / Congestive heart failure Less

新規CF6関連老化抑制蛋白NM_026333の作用機序解明と創薬への応用Principal InvestigatorOngoing
- Principal Investigator
  
  長内智宏
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hirosaki University
新規昇圧物質カップリングファクター６における老化促進機序の解明と抑制蛋白の同定Principal InvestigatorOngoing
- Principal Investigator
  
  長内智宏
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Hirosaki University
Molecular biological approach to the pathogenesis of coronary spastic angina: A study on the role of p122 protein
- Principal Investigator
  
  Okumura Ken
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Hirosaki University
Establishment of regulatory system against coupling factor 6-induced vascular damagePrincipal Investigator
- Principal Investigator
  
  OSANAI Tomohiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hirosaki University
Molecular biological approach to the pathogenesis of coronary spastic angina: A study on the role of p122 protein
- Principal Investigator
  
  OKUMURA Ken
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hirosaki University
Estimation of coupling factor 6-induced vascular damage and utilization for drug discoveryPrincipal Investigator
- Principal Investigator
  
  OSANAI Tomohiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hirosaki University
Role of novel vasoconstrictor coupling factor 6 in the pathogenesis of cardiac hypertrophy and cardiac failure
- Principal Investigator
  
  SASAKI Singo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hirosaki University
Clinical and molecular biological approach to the genesis of coronary artery spasm : A study on the role of p122 protein
- Principal Investigator
  
  OKUMURA Ken
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hirosaki University
Functional analysis of novel vasoconstrictor coupling factor 6 and clarification of mechanism for the genesis of cardiovascular disordersPrincipal Investigator
- Principal Investigator
  
  OSANAI Tomohiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hirosaki University
Clinical, Molecular and Biological Studies to the Genesis of Coronary Spastic Angin
- Principal Investigator
  
  OKUMURA Ken
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hirosaki University
Functional analysis of novel vasoconstrictor coupling factor 6 and its role in pathophysiologyPrincipal Investigator
- Principal Investigator
  
  OSANAI Tomohiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hirosaki University
Molecular and Biological Approaches to the Genesis of Coronary Spastic Angina : With special reference to the intracellular signaling pathway participating coronary artery contraction
- Principal Investigator
  
  OKAMURA Ken
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hirosaki University
A study on the role of coupling factor 6 in the pathogenesis of heart diseasePrincipal Investigator
- Principal Investigator
  
  OSANAI Tomohiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hirosaki University
Role of coupling factor 6 in the pathogenesis of cardiovascular diseasePrincipal Investigator
- Principal Investigator
  
  OSANAI Tomohiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hirosaki University
正常低密度リポ蛋白質(LDL)による泡沫細胞の形成法と粥状動脈硬化における意義Principal Investigator
- Principal Investigator
  
  長内智宏
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hirosaki University

[Journal Article] Enhanced transient receptor potential channel-mediated Ca2+ influx in the cells with phospholipase C-δ1 overexpression: its possible role in coronary artery spasm.2017
- Author(s)
  Murakami K, Osanai T, Tanaka M, Nishizaki K, Kinjo T, Tanno T, Ishida Y, Suzuki A, Endo T, Tomita H, Okumura K.
- Journal Title
  
  Fundam Clin Pharmacol
  
  Volume : 印刷中
- DOI
  10.1111/fcp.12269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461120, KAKENHI-PROJECT-16K09489
[Journal Article] Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression.2016
- Author(s)
  Tanno T, Tomita H, Narita I, Kinjo T, Nishizaki K, Ichikawa H, Kimura Y, Tanaka M, Osanai T, Okumura K.
- Journal Title
  
  J Cardiovasc Pharmacol
  
  Volume : 67 Pages : 503-509
- DOI
  10.1097/FJC.0000000000000374
- PMID
  info:pmid/26886190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461120, KAKENHI-PROJECT-16K09489
[Journal Article] Modified sympathetic nerve regulation in AKAP5-null mice.2016
- Author(s)
  Han C, Tomita H, Ohba T, Nishizaki K, Ogata Y, Matsuzaki Y, Sawamura D, Yanagisawa T, Osanai T, Imaizumi T, Matsubara A, Adachi T, Ono K, Okumura K, Murakami M.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : 469（4） Pages : 897-902
- DOI
  10.1016/j.bbrc.2015.12.057
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461120, KAKENHI-PROJECT-26461675
[Journal Article] Quality of Life in Physical and Psychological Health and Social Environment at Posthospitalization Period in Patients with Stroke.2016
- Author(s)
  Karube N, Sasaki A, Hondoh F, Odagiri C, Hagii J, Seino S, Yasujima M, Osanai T.
- Journal Title
  
  J Stroke Cerebrovasc Dis
  
  Volume : 25 Pages : 2482-2487
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09151
[Journal Article] Mitochondrial Inhibitory Factor Protein 1 Functions as an Endogenous Inhibitor for Coupling Factor 6.2016
- Author(s)
  Kawai M, Osanai T, Tanaka M, Magota K, Tomita H, Okumura K.
- Journal Title
  
  J Cell Biochem.
  
  Volume : 117 Pages : 1680-1687
- DOI
  10.1002/jcb.25461
- PMID
  info:pmid/26659871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461120, KAKENHI-PROJECT-16K09489
[Journal Article] Olmesartan inhibits cardiac hypertrophy in mice overexpressing renin independently of blood pressure: its beneficial effects on ACE2/Ang(1-7)/Mas axis and NADPH oxidase expression.2016
- Author(s)
  Tanno T, Tomita H, Narita I, Kinjo T, Nishizaki K, Ichikawa H, Kimura Y, Tanaka M, Osanai T, Okumura K.
- Journal Title
  
  J Cardiovasc Pharmacol.
  
  Volume : 67 Pages : 503-509
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09151
[Journal Article] Modified sympathetic nerve regulation in AKAP5-null mice.2016
- Author(s)
  Han C, Tomita H, Ohba T, Nishizaki K, Ogata Y, Matsuzaki Y, Sawamura D, Yanagisawa T, Osanai T, Imaizumi T, Matsubara A, Adachi T, Ono K, Okumura K, Murakami M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : 469 Pages : 897-902
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09151
[Journal Article] Mitochondrial Inhibitory Factor Protein 1 Functions as an Endogenous Inhibitor for Coupling Factor 6.2016
- Author(s)
  Kawai M, Osanai T, Tanaka M, Magota K, Tomita H, Okumura K.
- Journal Title
  
  J Cell Biochem
  
  Volume : 117 Pages : 1680-1687
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09151
[Journal Article] Enhanced p122RhoGAP/DLC-1 expression can be a cause of coronary spasm.2016
- Author(s)
  Kinjo T, Tanaka M, Osanai T, Shibutani S, Narita I, Tanno T, Nishizaki K, Ichikawa H, Kimura Y, Ishida Y, Yokota T, Shimada M, Homma Y, Tomita H, Okumura K.
- Journal Title
  
  PLOS ONE
  
  Volume : 10(12)
- DOI
  10.1371/journal.pone.0143884
- Year and Date
  2016-03-23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461120
[Journal Article] Plasma Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 as a Novel Prognostic Biomarker in Patients With ST-Segment Elevation Acute Myocardial Infarction.2015
- Author(s)
  Higuma T, Abe N, Tateyama S, Endo T, Shibutani S, Yokoyama H, Hanada K, Yamada M, Tomita H, Hanada H, Osanai T, Kume N, Okumura K.
- Journal Title
  
  Circ J
  
  Volume : 79 Pages : 641-648
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09151
[Journal Article] Deeply re-inverted T-wave at 14 days after the onset of first anterior acute myocardial infarction predicts improved left ventricular function at 6 months.2015
- Author(s)
  Yokoyama H, Tomita H, Nishizaki F, Hanada K, Shibutani S, Yamada M, Abe N, Higuma T, Osanai T, Okumura K.
- Journal Title
  
  Clin Cardiol.
  
  Volume : 38 Pages : 157-163
- DOI
  10.1002/clc.22366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461120
[Journal Article] Plasma soluble lectin-like oxidized low-density lipoprotein receptor-1 as a novel prognostic biomarker in patients with ST-segment elevation acute myocardial infarction.2015
- Author(s)
  Higuma T, Abe N, Tateyama S, Endo T, Shibutani S, Yokoyama H, Hanada K, Yamada M, Tomita H, Hanada H, Osanai T, Kume N, Okumura K.
- Journal Title
  
  Circ J.
  
  Volume : 79 Pages : 641-648
- DOI
  10.1253/circj.CJ-14-0904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461120
[Journal Article] Enhanced p122RhoGAP/DLC-1 Expression Can Be a Cause of Coronary Spasm2015
- Author(s)
  Kinjo T, Tanaka M, Osanai T, Shibutani S, Narita I, Tanno T, Nishizaki K, Ichikawa H, Kimura Y, Ishida Y, Yokota T, Shimada M, Homma Y, Tomita H, Okumura K
- Journal Title
  
  PLoS One
  
  Volume : 10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09151
[Journal Article] Deeply reinverted T wave at 14 days after the onset of first anterior acute myocardial infarction predicts improved left ventricular function at 6 months.2015
- Author(s)
  Yokoyama H, Tomita H, Nishizaki F, Hanada K, Shibutani S, Yamada M, Abe N, Higuma T, Osanai T, Okumura K
- Journal Title
  
  Clin Cardiol
  
  Volume : 38 Pages : 157-163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09151
[Journal Article] Impact of Sex Difference on Severity and Functional Outcome in Patients with Cardioembolic Stroke2015
- Author(s)
  Tomita H, Hagii J, Metoki N, Saito S, Shiroto H, Hitomi H, Kamada T, Seino S, Takahashi K, Baba Y, Sasaki S, Uchizawa T, Iwata M, Matsumoto S, Shoji Y, Tanno T, Osanai T, Yasujima M, Okumura K.
- Journal Title
  
  J Stroke Cerebrovasc Dis
  
  Volume : 24 Pages : 2613-2618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09151
[Journal Article] Coupling factor 6 attenuates CXCR4 expression through the HIF-1α and c-Src pathways and promotes endothelial apoptosis and inflammation.2014
- Author(s)
  Suzuki A, Osanai T, Tanaka M, Tomita H, Magota K, Okumura K
- Journal Title
  
  Hypertens Res
  
  Volume : 37 Pages : 708-715
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591089
[Journal Article] Effect of coupling factor 6 on chemokine receptors in vascular endothelial cells.2014
- Author(s)
  Suzuki A, Osanai T, Tanaka M, Endo T, Murakami K, Tomita H, Okumura K
- Journal Title
  
  Hirosaki Med J
  
  Volume : 64 Pages : 119-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591089
[Journal Article] Coupling factor 6 attenuates CXCR4 expression through the HIF-1α and c-Src pathways and promotes endothelial apoptosis and inflammation.2014
- Author(s)
  Suzuki A, Osanai T, Tanaka M, Tomita H, Magota K, Okumura K.
- Journal Title
  
  Hypertens Res.
  
  Volume : 37 Pages : 708-715
- DOI
  10.1038/hr.2014.65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461120
[Journal Article] Re-elevation of T-wave from day 2 to day 4 after successful percutaneous coronary intervention predicts chronic cardiac systolic dysfunction in patients with first anterior acute myocardial infarction2013
- Author(s)
  Nishizaki F, Tomita H, Yokoyama H, Higuma T, Abe N, Suzuki A, Endo T, Tateyama S, Ishida Y, Osanai T, Okumura K.
- Journal Title
  
  Heart Vessels
  
  Volume : 28 Pages : 704-713
- DOI
  10.1007/s00380-012-0313-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Acute myocardial infarction cases by a floating thrombus in the ascending aorta : A role of CD34-positive endothelial cells2013
- Author(s)
  Nishizaki F, Tomita H, Abe N, Kimura M, Higuma T, Osanai T, Yamauchi S, Daitoku K, Fukuda I, Kamata Y, Okumura K.
- Journal Title
  
  Journal of Cardiology cases
  
  Volume : 8
- DOI
  10.1016/j.jccase.2013.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Coupling factor 6 enhances the spontaneous microaggregation of platelets by decreasing cytosolic cAMP irrespective of antiplatelet therapy.2013
- Author(s)
  Sukekawa T, Osanai T, Nishizaki F, Metoki N, Hagii J, Kamada T, Yasujima M, Tomita H, Magota K, Okumura K.
- Journal Title
  
  Hypertens Res
  
  Volume : 36 Pages : 520-527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591089
[Journal Article] Re-elevation of T-wave from day 2 to day 4 after successful percutaneous coronary intervention predicts chronic cardiac systolic dysfunction in patients with first anterior acute myocardial infarction2013
- Author(s)
  Nishizaki F, Tomita H, Yokoyama H, Higuma T, Abe N, Suzuki A, Endo T, Tateyama S, Ishida Y, Osanai T, Okumura K
- Journal Title
  
  Heart Vessels
  
  Volume : 28 Pages : 704-713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591089
[Journal Article] Re-elevation of T-wave from day 2 to day 4 after successful percutaneous coronary intervention predicts chronic cardiac systolic dysfunction in patients with first anterior acute myocardial infarction.2013
- Author(s)
  Nishizaki F, Tomita H, Yokoyama H, Higuma T, Abe N, Suzuki A, Endo T, Tateyama S, Ishida Y, Osanai T, Okumura K.
- Journal Title
  
  Heart Vessels.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice.2012
- Author(s)
  Sagara S, Osanai T, Itoh T, Izumiyama K, Shibutani S, Hanada K, Yokoyama H, Yamamoto Y, Yokota T, Tomita H, Magota K, Okumura K.
- Journal Title
  
  J Hypertens
  
  Volume : 30 Pages : 778-786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591089
[Journal Article] Estrogen attenuates coupling factor 6-induced salt-sensitive hypertension and cardiac systolic dysfunction in mice.2012
- Author(s)
  Izumiyama K, Osanai T, Sagara S, Yamamoto Y, Itoh T, Sukekawa T, Nishizaki F, Magota K, Okumura K.
- Journal Title
  
  Hypertens Res.
  
  Volume : 35 Pages : 539-546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591089
[Journal Article] Coronary Vasospasm Induced in Transgenic Mouse with the Increased Phospholipase C-δ1 Activity.2012
- Author(s)
  Shibutani S, Osanai T, Ashitate T, Sagara S, Izumiyama K, Yamamoto Y, Hanada K, Echizen T, Tomita H, Fujita T, Miwa T, Matsubara H, Homma Y, Okumura K.
- Journal Title
  
  Circulation
  
  Volume : 125 Pages : 1027-1036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591089
[Journal Article] Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice.2012
- Author(s)
  Sagara S, Osanai T, Itoh T, Izumiyama K, Shibutani S, Hanada K, Yokoyama H, Yamamoto Y, Yokota T, Tomita H, Magota K, Okumura K.
- Journal Title
  
  J Hypertens.
  
  Volume : 30 Pages : 778-786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Coupling factor 6-induced activation of ecto-F(1)F (o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice.2012
- Author(s)
  Osanai T, Tanaka M, Magota K, Tomita H, Okumura K.
- Journal Title
  
  Diabetologia
  
  Volume : 55 Pages : 520-529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice2012
- Author(s)
  Sagara S, Osanai T, Izumiyama K, Shibutani S, Hanada K, Yokoyama H, Yamamoto Y, Yokota T, Tomita H, Magota K, Okumura K.
- Journal Title
  
  J Hypertens
  
  Volume : 30 Pages : 778-786
- DOI
  10.1097/HJH.0b013e3283505101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Coronary Vasospasm Induced in Transgenic Mouse With Increased Phospholipase C-δ1 Activity2012
- Author(s)
  Shibutani S, Osanai T, Ashitate T, Sagara S, Izumiyama K, Yamamoto Y, Hanada K, Echizen T, Tomita H, Fujita T, Miwa T, Matsubara H, Homma Y, Okumura K.
- Journal Title
  
  Circulation
  
  Volume : 28 Pages : 1027-1036
- DOI
  10.1161/CIRCULATIONAHA.111.064303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Estrogen attenuates coupling factor 6-induced salt-sensitive hypertension and cardiac systolic dysfunction in mice2012
- Author(s)
  Izumiyama K, Osanai T, Sagara S, Yamamoto Y, Itoh T, Sukekawa T, Nishizaki F, Magota K, Okumura K.
- Journal Title
  
  Hypertens Res
  
  Volume : 35 Pages : 539-546
- DOI
  10.1038/hr.2011.232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Matrix metalloprotein-9 activation under cell-to-cell interaction between endothelial cells and monocytes : possible role of hypoxia and tumor necrosis factor-α2012
- Author(s)
  Yamamoto Y, Osanai T, Nishizaki F, Sukekawa T, Izumiyama K, Sagara S, Okumura K.
- Journal Title
  
  Heart Vessels
  
  Volume : 27 Pages : 624-633
- DOI
  10.1007/s00380-011-0214-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Coupling factor 6-induced activation of ecto-F(1)F (o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice2012
- Author(s)
  Osanai T, Tanaka M, Magota K, Tomita H, Okumura K.
- Journal Title
  
  Diabetologia
  
  Volume : 55 Pages : 520-529
- DOI
  10.1007/s00125-011-2341-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Lipocalin-Type PGD Synthase as a Novel Biomarker for Coronary Vasospasm2011
- Author(s)
  Osanai T, et al
- Journal Title
  
  Circ J
  
  Volume : 75 Pages : 784-785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590946
[Journal Article] Inhibition of P38 MAP Kinase Attenuates Left Ventricular Hypertrophy and Inhibits Progression of Systolic Dysfunction on Pressure-Overload Induced Pathological Cardiac Hypertrophy in Mice2011
- Author(s)
  Hanada K, Osanai T, Sukekawa T, Ohya F, Izumiyama K, Sagara S, Ito T, Yamamoto Y, Sibutani S, Tomita H, Okumura K
- Journal Title
  
  Hirosaki Med J
  
  Volume : 62 Pages : 18-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Mutation Analysis ABCC9 Gene in Japanese Patients with Coronary Spastic Angina2011
- Author(s)
  Shibutani S, Osanai T, Oya H, Sagara S, Izumiyama K, Yamamoto Y, Hanada K, Tomita H, Okumura K
- Journal Title
  
  Hirosaki Med J
  
  Volume : 62 Pages : 27-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Inhibition of P38 MAP Kinase Attenuates Left Ventricular Hypertrophy and Inhibits Progression of Systolic Dysfunction on Pressure-Overload Induced Pathological Cardiac Hypertrophy in Mice.2011
- Author(s)
  Hanada K, Osanai T, Sukekawa T, Ohya F, Izumiyama K, Sagara S, Ito T, Yamamoto Y, Sibutani S, Tomita H, Okumura K.
- Journal Title
  
  Hirosaki Med J
  
  Volume : 62 Pages : 18-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Effects of pravastatin and rosuvastatin on the generation of adiponectin in the visceral adipose tissue in patients with coronary artery disease.2011
- Author(s)
  Yokoyama H, Saito S, Daitoku K, Fukuda I, Higuma T, Hanada H, Osanai T, Okumura K.
- Journal Title
  
  Fundam Clin Pharmacol.
  
  Volume : 25 Pages : 378-387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Nongenomic response to aldosterone.2011
- Author(s)
  Osanai T, Yamada M, Okumura K.
- Journal Title
  
  Hypertension.
  
  Volume : 58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Mutation Analysis ABCC9 Gene in Japanese Patients with Coronary Spastic Angina.2011
- Author(s)
  Shibutani S, Osanai T, Oya H, Sagara S, Izumiyama K, Yamamoto Y, Hanada K, Tomita H, Okumura K.
- Journal Title
  
  Hirosaki Med J.
  
  Volume : 62 Pages : 27-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Effects of pravastatin and rosuvastatin on the generation of adiponectin in the visceral adipose tissue in patients with coronary artery disease2011
- Author(s)
  Yokoyama H, et al
- Journal Title
  
  Fundam Clin Pharmacol
  
  Volume : 25 Pages : 378-387
- DOI
  10.1111/j.1472-8206.2010.00847.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590946, KAKENHI-PROJECT-23591077
[Journal Article] Effects of pravastatin and rosuvastatin on the generation of adiponectin in the visceral adipose tissue in patients with coronary artery disease.2011
- Author(s)
  Yokoyama H, Osanai T, Okumura K, et al
- Journal Title
  
  Fundam Clin Pharmacol. 25
  
  Pages : 378-387
- Data Source
  KAKENHI-PROJECT-20590856
[Journal Article] Nongenomic response to aldosterone2011
- Author(s)
  Osanai T, Yamada M, Okumura K
- Journal Title
  
  Hypertension
  
  Volume : 58
- DOI
  10.1161/HYPERTENSIONAHA.111.174680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591077
[Journal Article] Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke : A possible linkage to homocysteine2010
- Author(s)
  Osanai T, Fujiwara N, Sasaki S, Metoki N, Saitoh G, Tomita H, Nishimura T, Shibitani S, Yokoyama H, Konta Y, Magota K, Okumura K
- Journal Title
  
  Ann Med
  
  Volume : 42 Pages : 79-86
- Data Source
  KAKENHI-PROJECT-21590946
[Journal Article] Overexpression of coupling factor 6 causes cardiac dysfunction under high salt diet in mice2010
- Author(s)
  Ashitate T, Osanai T, Tanaka M, Magota K, Echizen T, Izumiyama K, Yokoyama H, Shibutani S, Hanada K, Tomita H, Okumura K
- Journal Title
  
  J Hypertens
  
  Volume : 28 Pages : 2243-2251
- Data Source
  KAKENHI-PROJECT-21590946
[Journal Article] Overexpression of coupling factor 6 causes cardiac dysfunction under high salt diet in mice.2010
- Author(s)
  Ashitate T, Osanai T, Tanaka M, Magota K, Echizen T, Izumiyama K, Yokoyama H, Shibutani S, Hanada K, Tomita H, Okumura K
- Journal Title
  
  J Hypertens 28
  
  Pages : 2243-2251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590855
[Journal Article] Novel pro-atherogenic molecule-coupling factor 6 is elevated in patients with stroke : a possible linkage to homocysteine.2010
- Author(s)
  Osanai T, Okumura K, et al
- Journal Title
  
  Ann Med
  
  Volume : 42 Pages : 79-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590856
[Journal Article] Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke : A possible linkage to homocysteine.2010
- Author(s)
  Osanai T, et al
- Journal Title
  
  Ann Med 42
  
  Pages : 79-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590946
[Journal Article] p122 Protein Enhances Intracellular Calcium Increase to Acetylcholine. Its Possible Role in the Pathogenesis of Coronary Spastic Angina.2010
- Author(s)
  Murakami R, Osanai T, Okumura K, et al
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 30
  
  Pages : 1968-1975
- Data Source
  KAKENHI-PROJECT-20590856
[Journal Article] Effects of telmisartan on markers of ventricular remodeling in patients with acute myocardial infarction : comparison with enalapril.2010
- Author(s)
  Yokota T, Osanai T, Okumura K, et al
- Journal Title
  
  Heart Vessels. 25
  
  Pages : 460-8
- Data Source
  KAKENHI-PROJECT-20590856
[Journal Article] Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke : a possible linkage to homocysteine.2010
- Author(s)
  Osanai T, Okumura K, et al
- Journal Title
  
  Ann Med. 42
  
  Pages : 79-86
- Data Source
  KAKENHI-PROJECT-20590856
[Journal Article] Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke : A possible linkage to homocysteine.2010
- Author(s)
  Osanai T, et al
- Journal Title
  
  Ann Med 42
  
  Pages : 79-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590855
[Journal Article] Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke : A possible linkage to homocysteine.2010
- Author(s)
  Osanai T, Fujiwara N, Sasaki S, Metoki N, Saitoh G, Tomita H, Nishimura T, Shibitani S, Yokoyama H, Konta Y, Magota K, Okumura K
- Journal Title
  
  Ann Med. 42
  
  Pages : 79-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590855
[Journal Article] Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in the vascular endothelial cells : A role of acidosis-induced c-Src activation2009
- Author(s)
  Echizen T, Osanai T, Ashitate T,Yokoyama H, Shibutani S, Tanaka M, Tomita H, Koji Magota K, Okumura K.
- Journal Title
  
  Hypertens Res. 32
  
  Pages : 182-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590800
[Journal Article] Generation and characterization of coupling factor 6-overexpressing transgenic mice2009
- Author(s)
  Asitate T, Osanai T, Tanaka M, Magota K, Echizen T, Tomita T, Okumura K
- Journal Title
  
  Hirosaki Medical Journal 60
  
  Pages : 18-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590800
[Journal Article] Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells.2009
- Author(s)
  Osanai T, Magota K, Okumura K
- Journal Title
  
  Naunyn-Schmied Arch Pharmacol 380
  
  Pages : 205-214
- Data Source
  KAKENHI-PROJECT-20590856
[Journal Article] Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in the vascular endothelial cells : A role of acidosis-induced c-Src activation2009
- Author(s)
  Echizen T, Osanai T, et.al.
- Journal Title
  
  Hypertens Res 32
  
  Pages : 182-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590800
[Journal Article] Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells2009
- Author(s)
  Osanai T, et.al.
- Journal Title
  
  Cardiovasc Res 81
  
  Pages : 780-787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590800
[Journal Article] Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells2009
- Author(s)
  Osanai T, Tomita H, Kushibiki M, Yamada M, Tanaka M, Ashitate T, Echizen T, Katoh C, Magota K, Okumura K.
- Journal Title
  
  Cardiovasc Res. 81
  
  Pages : 780-787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590800
[Journal Article] Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells.2009
- Author(s)
  Osanai T, Okumura K, et al
- Journal Title
  
  Naunyn-Schmied Arch Pharmacol 380
  
  Pages : 205-214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590856
[Journal Article] Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats2009
- Author(s)
  Osanai T, Tomita H, Yamada M, Tanaka M, Ashidate T, Echizen T, Katoh C, Magota K, Okumura K
- Journal Title
  
  J Hypertens
  
  Volume : 27 Pages : 1823-1828
- Data Source
  KAKENHI-PROJECT-21590946
[Journal Article] Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells2009
- Author(s)
  Osanai T, Magota K, Okumura K
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol
  
  Volume : 380 Pages : 205-214
- Data Source
  KAKENHI-PROJECT-21590946
[Journal Article] Impact of telmisartan on coronary stenting in patients with acute myocardial infarction compared with enalapril.2009
- Author(s)
  Yokoyama J, Osanai T, Okumura K, et al
- Journal Title
  
  Int J Cardiol 132
  
  Pages : 114-120
- Data Source
  KAKENHI-PROJECT-20590856
[Journal Article] Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells.2009
- Author(s)
  Osanai T, et al
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol. 380
  
  Pages : 205-214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590946
[Journal Article] Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats.2009
- Author(s)
  Osanai T, et al
- Journal Title
  
  J Hypertens 27
  
  Pages : 1823-1828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590946
[Journal Article] Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells.2009
- Author(s)
  Osanai T, Okumura K, et al
- Journal Title
  
  Cardiovasc Res 81
  
  Pages : 780-787
- Data Source
  KAKENHI-PROJECT-20590856
[Journal Article] Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in vascular endothelial cells : a role of acidosis-induced c-Src activation.2009
- Author(s)
  Echizen T, Osanai T, Okumura K, et al
- Journal Title
  
  Hypertens Res. 32
  
  Pages : 182-187
- Data Source
  KAKENHI-PROJECT-20590856
[Journal Article] Coupling factor 6 enhances Src-mediated responsiveness to an giotensin II in resistance arterioles and cells2009
- Author(s)
  Osanai T, et.al.
- Journal Title
  
  Cardiovasc Res 81
  
  Pages : 780-787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590855
[Journal Article] Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells2009
- Author(s)
  Osanai T, Tomita H, Kushibiki M, Yamada M, Tanaka M, Ashitate T, Echizen T, Katoh C, Magota K, Okumura K
- Journal Title
  
  Cardiovasc Res
  
  Volume : 81 Pages : 780-787
- Data Source
  KAKENHI-PROJECT-21590946
[Journal Article] Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats.2009
- Author(s)
  Osanai T, et al
- Journal Title
  
  J Hypertens 27
  
  Pages : 1823-1828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590855
[Journal Article] Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in the vascular endothelial cells : A role of acidosis-induced c-Src activation2009
- Author(s)
  Echizen T, Osanai T, et.al.
- Journal Title
  
  Hypertens Res 32
  
  Pages : 182-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590855
[Journal Article] Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells.2009
- Author(s)
  Osanai T, et al
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol 380
  
  Pages : 205-214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590855
[Journal Article] Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in the vascular endothelial cells : A role of acidosis-induced c-Src activation.2009
- Author(s)
  Echizen T, Osanai T, Ashitate T, Yokoyama H, Shibutani S, Tanaka M, Tomita H, Koji Magota K, Okumura K
- Journal Title
  
  Hypertens Res 32
  
  Pages : 182-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590855
[Journal Article] Generation and characterization of coupling factor 6-overexpressing transgenic mice.2009
- Author(s)
  Asitate T, Osanai T, Tanaka M, Magota K, Echizen T, Tomita T, Okumura K
- Journal Title
  
  Hirosaki Medical Journal 60
  
  Pages : 18-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590855
[Journal Article] Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells.2009
- Author(s)
  Osanai T, Magota K, Okumura K
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol. 380
  
  Pages : 205-214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590855
[Journal Article] Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats.2009
- Author(s)
  Osanai T, Tomita H, Yamada M, Tanaka M, Ashidate T, Echizen T, Katoh C, Magota K, Okumura K
- Journal Title
  
  J Hypertens 27
  
  Pages : 1823-1828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590855
[Journal Article] Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells.2009
- Author(s)
  Osanai T, Tomita H, Kushibiki M, Yamada M, Tanaka M, Ashitate T, Echizen T, Katoh C, Magota K, Okumura K
- Journal Title
  
  Cardiovasc Res. 81
  
  Pages : 780-787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590855
[Journal Article] Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule2008
- Author(s)
  Kumagai A, Osanai T, Katoh C, Tanaka M,Tomita H, Morimoto T, Murakami R, Magota K, Okumura K
- Journal Title
  
  Atherosclerosis 200
  
  Pages : 45-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590800
[Journal Article] Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule2008
- Author(s)
  Kumagai A, Osanai T, et.al.
- Journal Title
  
  Atherosclerosis 200
  
  Pages : 45-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590800
[Journal Article] Increased Adiponectin synthesis in the visceral adipose tissue in men with coronary artery disease treated with pravastatin: A role of the attenuation of oxidative stress2008
- Author(s)
  Saito S, Fujiwara T, Matsunaga T, Minagawa K, Fukui K, Fukuda I, Osanai T, Okumura K.
- Journal Title
  
  Atherosclerosis (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590758
[Journal Article] Vasoconstrictor effect of aldosterone via angiotensin II type 1 (AT1) receptor: Possible role of AT1 receptor dimerization2008
- Author(s)
  Yamada M, Kushibiki M, Osanai T, Tomita H, Okumura K.
- Journal Title
  
  Cardiovasc Res (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590758
[Journal Article] Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule2008
- Author(s)
  Kumagai A, Osanai T, Katoh C, Tanaka M, Tomita H, Morimoto T, Murakami R, Magota K, Okumura K.
- Journal Title
  
  Atherosclerosis (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590758
[Journal Article] Coupling factor 6 downregulates platelet endothelial cell adhesion mol ecule-1 via c-Src activation and acts as a oroatherogenic molecule2008
- Author(s)
  Kumagai A. Osanai T, et.al.
- Journal Title
  
  Atherosclerosis 200
  
  Pages : 45-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590855
[Journal Article] Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule.2008
- Author(s)
  Kumagai A, Osanai T, Katoh C, Tanaka M, Tomita H, Morimoto T, Murakami R, Magota K, Okumura K
- Journal Title
  
  Atherosclerosis. 200
  
  Pages : 45-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590855
[Journal Article] Therapeutic challenge to adiposity of the heart2007
- Author(s)
  Osanai T, at. al.
- Journal Title
  
  Circ Res 100
  
  Pages : 1106-1108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590800
[Journal Article] Therapeutic challenge to adiposity of the heart2007
- Author(s)
  Osanai T, Okumura K.
- Journal Title
  
  Circ Res 100
  
  Pages : 1106-1108
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590758
[Journal Article] Aldosterone cause vasoconstriction in coronary arterioles of rats via angiotensin II type-1 receptor: Influence of hypertension2007
- Author(s)
  Kushibiki M, Yamada M, Oikawa K, Tomita H, Osanai T, Okumura K.
- Journal Title
  
  Eur J Pharmacol 572
  
  Pages : 182-188
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590758
[Journal Article] Intracellular signaling for vasoconstrictor coupling factor 6 : novel function of b-subunit of ATP synthase as receptor.2005
- Author(s)
  Osanai T et al.
- Journal Title
  
  Hypertension 46
  
  Pages : 1140-1146
- Data Source
  KAKENHI-PROJECT-17590698
[Journal Article] Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells.2003
- Author(s)
  Osanai T, et al.
- Journal Title
  
  Hypertension 42
  
  Pages : 985-990
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease.2003
- Author(s)
  Osanai T, Okumura K, et al.
- Journal Title
  
  Kidney International 64
  
  Pages : 2291-2297
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells.2003
- Author(s)
  Osanai T, Okumura K, et al.
- Journal Title
  
  Hypertension 42
  
  Pages : 985-990
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease.2003
- Author(s)
  Osanai T, et al.
- Journal Title
  
  Kidney International 64
  
  Pages : 2291-2297
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Circulating coupling factor 6 in human hypertension : role of reactive oxcygen species.2003
- Author(s)
  Osanai T, et al.
- Journal Title
  
  J Hypertens 21
  
  Pages : 2323-2328
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Circulating coupling factor 6 in human hypertension : role of reactive oxcygen species.2003
- Author(s)
  Osanai T, Okumura K, et al.
- Journal Title
  
  J Hypertens 21
  
  Pages : 2323-2328
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells.2003
- Author(s)
  Osanai T, Okumura K, et al.
- Journal Title
  
  Hypertension 42・5
  
  Pages : 985-990
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease.2003
- Author(s)
  Osanai T, Okumura K, et al.
- Journal Title
  
  Kidney International 64・6
  
  Pages : 2291-2297
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Relationship between salt intake, Nitric Oxide and Asymmetric Dimethylarginine and its relevance to patients with end-stage renal disease.2002
- Author(s)
  Osanai T, et al.
- Journal Title
  
  Blood Purif 20
  
  Pages : 466-468
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Mitochondorial coupling factor 6 as an endogenous inhibitor of prostacyclin synthesis and an endogenous vasoconstrictor.2002
- Author(s)
  Osanai T, et al.
- Journal Title
  
  International Congress Series 1244
  
  Pages : 131-141
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Mitochondorial coupling factor 6 as an endogenous inhibitor of prostacyclin synthesis and an endogenous vasoconstrictor.2002
- Author(s)
  Osanai T, Okumura K, et al.
- Journal Title
  
  International Congress Series 1244
  
  Pages : 131-141
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Relationship between salt intake, Nitric Oxide and Asymmetric Dimethylarginine and its relevance to patients with end-stage renal disease.2002
- Author(s)
  Osanai T, Okumura K, et al.
- Journal Title
  
  Blood Purif 20
  
  Pages : 466-468
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Mitochondrial coupling factor 6 as a potent endogenous vasoconstrictor.2001
- Author(s)
  Osanai T, et al.
- Journal Title
  
  J Clin Invest 108
  
  Pages : 1023-1030
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Mitochondrial coupling factor 6 is present on the surface of human vascular endothelial cells and is released by shear stress.2001
- Author(s)
  Osanai T, et al.
- Journal Title
  
  Circulation 104
  
  Pages : 3132-3136
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Cross talk between prostacyclin and nitric oxide under shear in smooth muscle cell. Role in monocyte adhesion.2001
- Author(s)
  Osanai T, et al.
- Journal Title
  
  Am J Physiol 281
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Mitochondrial coupling factor 6 as a potent endogenous vasoconstrictor.2001
- Author(s)
  Osanai T, Okumura K, et al.
- Journal Title
  
  J Clin Invest 108
  
  Pages : 1023-1030
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590712
[Journal Article] Cross talk between prostacyclin and nitric oxide under shear in smooth muscle cell. Role in monocyte adhesion.2001
- Author(s)
  Osanai T, Okumura K, et al.
- Journal Title
  
  Am J Physiol 281
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590712
[Presentation] Disruption of A-kinase Anchoring Protein 150 Induces Coronary Spasm through Enhancement of Calcium Sensitization2016
- Author(s)
  西崎公貴、富田泰史、市川博章、木村嘉宏、金城貴彦、丹野倫宏、田中真実、長内智宏、奥村謙
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Year and Date
  2016-03-20
- Data Source
  KAKENHI-PROJECT-26461120
[Presentation] Enhanced p122RhoGAP/DLC-1 Expression can be a Cause of Coronary Spasm2016
- Author(s)
  金城貴彦、田中真実、長内智宏、澁谷修司、石田祐司、丹野倫宏、西崎公貴、市川博章、木村嘉宏、富田泰史、奥村謙
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Year and Date
  2016-03-20
- Data Source
  KAKENHI-PROJECT-26461120
[Presentation] Coupling factor 6は核内酸性化によるautophagy障害を介して老化を促進させ、IF1はその作用に拮抗する作用を有する2016
- Author(s)
  長内智宏、樋熊拓未、富田泰史
- Organizer
  第39回日本高血圧学会総会
- Place of Presentation
  仙台国際センター(宮城県仙台市）
- Year and Date
  2016-09-30
- Data Source
  KAKENHI-PROJECT-15K09151
[Presentation] Coupling factor 6 accelerates aging by synchronizing primary aging hallmarks such as telomere attrition and a blocking effect of ATPase inhibitory factor 12016
- Author(s)
  Tomohiro Osanai, Kei Izumiyama, Makoto Tanaka, Hirofumi Tomita, Akihiro Kobayashi, Ken Okumura
- Organizer
  AHA Scientific Sessions 2016
- Place of Presentation
  New Orleans, Louisiana, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09151
[Presentation] Coronary Vasospasm Induced in Transgenic Mouse With Overexpression of p122RhoGAP/DLC12015
- Author(s)
  Takahiko Kinjo, Makoto Tanaka, Tomohiro Osanai, Ikuyo Narita, Tomohiro Tannno, Kimitaka Nishizaki, Shuji Shibutani, Yuji Ishida, Hirofumi Tomita, Yoshimi Homma, and Ken Okumura
- Organizer
  AHA2015
- Place of Presentation
  オーランド市（アメリカ合衆国）
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461120
[Presentation] 食塩はcoupling factor 6と同様に細胞内酸性化を介して老化スイッチをオンする2015
- Author(s)
  長内智宏、泉山圭、富田泰史、奥村謙
- Organizer
  第38回日本高血圧学会
- Place of Presentation
  ひめぎんホール（愛媛県松山市）
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-15K09151
[Presentation] Coupling factor 6 is an endogenous stimulator for atherosclerosis through salt-sensitive hypertension and type 2 diabetes2015
- Author(s)
  Tomohiro Osanai, Makoto Tanaka, Kei Izumiyama, Hirofumi Tomita, Ken Okumura
- Organizer
  17TH International Congress on Atherosclerosis
- Place of Presentation
  Amsterdam, Netherland
- Year and Date
  2015-05-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09151
[Presentation] Chronic Nuclear Acidosis Defines Aging and Lifespan by Histone 4 Lysine 5 Acetylation in Mice2014
- Author(s)
  Osanai T, Okumura K.
- Organizer
  AHA2014
- Place of Presentation
  McCormick Place, Chicago, Illinois
- Year and Date
  2014-11-19
- Data Source
  KAKENHI-PROJECT-26461120
[Presentation] Coupling factor 6 promotes endothelial apoptosis and inflammation by attenuating CXCR4 expression through HIF-1alpha and cSrc pathways2013
- Author(s)
  Tomohiro Osanai,
- Organizer
  2013年米国心臓病学会議
- Place of Presentation
  ダラス (アメリカ）
- Data Source
  KAKENHI-PROJECT-24591089
[Presentation] Coupling factor 6のprotonを介したhistone 4 acetylationは個体老化を促進させlifespan を短縮する2013
- Author(s)
  長内智宏
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24591089
[Presentation] Coupling factor 6 accelerates aging and shortens lifespan through reduced autophagy by proton-mediated histone acetylation2013
- Author(s)
  Tomohiro Osanai,
- Organizer
  2013年米国心臓病学会議
- Place of Presentation
  ダラス (アメリカ）
- Data Source
  KAKENHI-PROJECT-24591089
[Presentation] Coupling factor 6 affects lifespan by reduced autophagy irrespectively of blood pressure.2012
- Author(s)
  Tomohiro Osanai, Ken Okumura
- Organizer
  アメリカ心臓協会学会　(AHA) 2012
- Place of Presentation
  ロサンゼルス, カリフォルニア
- Data Source
  KAKENHI-PROJECT-24591089
[Presentation] Coupling factor 6は細胞内酸性化を介してAutophagyを障害し細胞老化とLifespanの短縮を惹起する2012
- Author(s)
  長内智宏、泉山圭、祐川誉徳、奥村謙
- Organizer
  第35回日本高血圧学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24591089
[Presentation] Coupling factor 6 induces tissue acidosis and thereby salt-sensitive hypertension with diabetes by Rac1 activation and insulin receptor inactivation2011
- Author(s)
  Osanai T
- Organizer
  Scientific Sessions 2011 (American Heart Association)
- Place of Presentation
  Orland (USA)
- Data Source
  KAKENHI-PROJECT-21590946
[Presentation] Coupling factor 6は細胞内酸性化を介してRac1を活性化し食塩感受性高血圧とインスリン抵抗性を惹起する2011
- Author(s)
  長内智宏
- Organizer
  第34回日本高血圧学会総会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-21590946
[Presentation] Coupling factor 6 induces tissue acidosis and thereby salt-sensitive hypertension with diabetes by Rac1 activation and insulin receptor inactivation2011
- Author(s)
  Osanai T, Okumura K
- Organizer
  Scientific Sessions 2011 (American Heart Association)
- Place of Presentation
  Orland (USA)
- Data Source
  KAKENHI-PROJECT-21590946
[Presentation] Coupling factor 6は細胞内酸性化を介してRac1を活性化し食塩感受性高血圧とインスリン抵抗性を惹起する2011
- Author(s)
  長内智宏、泉山圭、相楽繁樹、山本祐子、奥村謙
- Organizer
  第34回日本高血圧学会総会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-21590946
[Presentation] Interaction between coupling factor 6 and ecto F1Fo complex induces hypertension and diabetes by tissue acidosis2010
- Author(s)
  Osanai T, Okumura K
- Organizer
  Scientific Sessions 2010 (American Heart Association)
- Place of Presentation
  Chicago (USA)
- Data Source
  KAKENHI-PROJECT-21590946
[Presentation] 新規の細胞内pH調節機構F_1F_o complexはcoupling factor 6で活性化され血圧並びに糖代謝を調節する2010
- Author(s)
  長内智宏、渋谷修司、花田賢二、泉山圭、相楽繁樹、山本祐子、奥村謙
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21590946
[Presentation] Interaction between coupling factor 6 and ecto-F1Fo complex induces hy pertension and diabetes by tissue acidosis2010
- Author(s)
  Osanai T
- Organizer
  Scientific Sessions 2010 (American Heart Association)
- Place of Presentation
  Chicago, USA
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-21590946
[Presentation] 新規の細胞内pH調節機構F_1F_o complexはcoupling factor 6で活性化され血圧並びに糖代謝を調節する2010
- Author(s)
  長内智宏、渋谷修司、花田賢二、泉山圭、相楽繁樹、山本祐子、奥村謙
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20590855
[Presentation] Coupling factor 6 enhances the action of angiotensin II and causes insulin resistance in mice2009
- Author(s)
  Osanai T, Okumura K
- Organizer
  Scientific Sessions 2009 (American Heart Association)
- Place of Presentation
  Orland (USA)
- Data Source
  KAKENHI-PROJECT-21590946
[Presentation] 新規の昇圧物質coupling factor 6 はcSrcの活性化を介してangiotensin IIの収縮反応を亢進させる2009
- Author(s)
  長内智宏、櫛引基、山田雅大、奥村謙
- Organizer
  第32回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-21590946
[Presentation] Coupling factor 6 enhances the action of angiotensin II and causes insulin resistance in mice2009
- Author(s)
  Osanai T
- Organizer
  Scientific Sessions 2009(American Heart Association)
- Place of Presentation
  Orlando, USA
- Year and Date
  2009-11-15
- Data Source
  KAKENHI-PROJECT-21590946
[Presentation] 新規の昇圧物質coupling factor 6はcSrcの活性化を介してangiotensin IIの収縮反応を亢進させる2009
- Author(s)
  長内智宏、櫛引基、山田雅大、奥村謙
- Organizer
  第32回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-20590855
[Presentation] Coupling factor 6 enhances the action of angiotensin II and causes insulin resistance in mice.2009
- Author(s)
  長内智宏, 奥村謙
- Organizer
  Scientific Sessions 2009 (American Heart Association)
- Place of Presentation
  Orland (USA)
- Data Source
  KAKENHI-PROJECT-20590855
[Presentation] 高血圧と糖尿病の病態形成における細胞内酸性化の意義 : Coupling factor 6過剰発現マウスを用いた解析2008
- Author(s)
  長内智宏、芦立俊宗、越前崇、山田雅大、奥村謙
- Organizer
  第31回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-19590800
[Presentation] Overexpression of coupling factor 6 links hypertension to diabetes by c-Src-mediated signaling pathway in mice2008
- Author(s)
  Tomohiro Osanai, Makoto Tanaka,Takashi Echizen, Toshihiro Ashitate,Hirofumi Tomita, Ken Okumura
- Organizer
  Scientific Sessions 2008(American Heart Association)
- Place of Presentation
  NewOrleans (USA)
- Data Source
  KAKENHI-PROJECT-19590800
[Presentation] Overexpression of coupling factor 6 links hypertension to diabetes by c-Src-mediated sianalin2 oathwav in mice2008
- Author(s)
  Osanai T
- Organizer
  Scientific Sessions 2008 (American Heart Association)
- Place of Presentation
  New Orleans, USA
- Year and Date
  2008-11-11
- Data Source
  KAKENHI-PROJECT-19590800
[Presentation] Overexpression of coupling factor 6 links hypertension to diabetes by c-Src-mediated signaling pathway in mice.2008
- Author(s)
  Osanai T, Tanaka M, Echizen T, Ashitate T, Tomita H, Okumura K.
- Organizer
  Scientific Sessions 2008 (American Heart Association)
- Place of Presentation
  New Orleans (USA)
- Data Source
  KAKENHI-PROJECT-20590855
[Presentation] 高血圧と糖尿病の病態形成における細胞内酸性化の意義:Coupling factor 6過剰発現マウスを用いた解析2008
- Author(s)
  長内智宏、芦立俊宗、越前崇、山田雅大、奥村謙
- Organizer
  第31回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-20590855
[Presentation] Interaction between coupling factor 6 and ecto F1Fo complex induces hypertension and diabetes by tissue acidosis.2008
- Author(s)
  長内智宏, 奥村謙
- Organizer
  Scientific Sessions 2008 (American Heart Association)
- Place of Presentation
  Chicago (USA)
- Data Source
  KAKENHI-PROJECT-20590855
[Presentation] 新規の昇圧物質coupling factor 6の細胞内情報伝達機構とカルシウムシグナル2007
- Author(s)
  長内智宏、芦立俊宗、斎藤新、奥村謙
- Organizer
  第30回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-19590800
[Presentation] Coupling factor 6 activatesc-src by intracellular acidosis and enhances calcium signaling in resistance arterioles vascular smooth muscle cells2007
- Author(s)
  Tomohiro Osanai, Makoto Tanaka,Hirofumi Tomita, Masahiro Yamada, Reiichi Murakami, Toshihiro Ashitate, Takashi Echizen, Chisato Katoh, Hiroaki Yokoyama, Ken Okumura
- Organizer
  Scientific Session 2007 (American Heart Association)
- Place of Presentation
  Orland(USA)
- Data Source
  KAKENHI-PROJECT-19590800
[Presentation] Coupling factor 6activates c-Src by intracellular acidosis and enhances Calcium signaling in resistance arteriole smooth muscle cells2007
- Author(s)
  Osanai T, et. al.
- Organizer
  Scientific Sessions 2007(American Heart Association)
- Place of Presentation
  Orland, USA
- Year and Date
  2007-11-05
- Data Source
  KAKENHI-PROJECT-19590800
[Presentation] p122 protein, a positive regulator for phospholipase C-δ1, is up-regulated human coronary spasm by-228G-A variant for the promoter2007
- Author(s)
  Murakami R, Osanai T, Tomita H, Okumura K.
- Organizer
  Scientific Sessions 2007, American Heart Association
- Place of Presentation
  Orlando, FL, U.S.A.
- Year and Date
  2007-11-06
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590758
[Presentation] Chronic nuclear acidosis defines aging and lifespan by histone 4 lysine 5 acetylation in mice.
- Author(s)
  Osanai T, Okumura K
- Organizer
  Scientific Sessions 2014 (American Heart Association)
- Place of Presentation
  Chicago (USA)
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-24591089
[Presentation] Coupling factor 6は核内酸性化による核膜ラミナ構造異常を介して老化・寿命を規定する
- Author(s)
  長内智宏、泉山圭、山田雅大、樋熊拓未、富田泰史、奥村謙
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  横浜
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-24591089

1. OKUMURA Ken (20185549)

# of Collaborated Projects : 13results

# of Collaborated Products : 109results
2. KAMADA Takaatsu (90281930)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
3. SASAKI Singo (20344591)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
4. Matsuzaki Yasushi

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
5. 澤村大輔

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

OSANAI Tomohiro 長内 智宏

長内 智芳 オサナイ トモヒロ

Research Projects

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Co-Researchers

新規CF6関連老化抑制蛋白NM_026333の作用機序解明と創薬への応用Principal InvestigatorOngoing

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新規昇圧物質カップリングファクター６における老化促進機序の解明と抑制蛋白の同定Principal InvestigatorOngoing

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Molecular biological approach to the pathogenesis of coronary spastic angina: A study on the role of p122 protein

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Establishment of regulatory system against coupling factor 6-induced vascular damagePrincipal Investigator

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Molecular biological approach to the pathogenesis of coronary spastic angina: A study on the role of p122 protein

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Estimation of coupling factor 6-induced vascular damage and utilization for drug discoveryPrincipal Investigator

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Role of novel vasoconstrictor coupling factor 6 in the pathogenesis of cardiac hypertrophy and cardiac failure

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Clinical and molecular biological approach to the genesis of coronary artery spasm : A study on the role of p122 protein

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Functional analysis of novel vasoconstrictor coupling factor 6 and clarification of mechanism for the genesis of cardiovascular disordersPrincipal Investigator

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Clinical, Molecular and Biological Studies to the Genesis of Coronary Spastic Angin

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Functional analysis of novel vasoconstrictor coupling factor 6 and its role in pathophysiologyPrincipal Investigator

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Molecular and Biological Approaches to the Genesis of Coronary Spastic Angina : With special reference to the intracellular signaling pathway participating coronary artery contraction

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A study on the role of coupling factor 6 in the pathogenesis of heart diseasePrincipal Investigator

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OSANAI Tomohiro 長内智宏

長内智芳オサナイトモヒロ