KUWATA Kazuo 桑田一夫

Researcher Number	00170142
Other IDs
Affiliation *help	2014 – 2016 : 岐阜大学, 大学院連合創薬医療情報研究科, 教授 2012 – 2014 : 岐阜大学, 連合創薬医療情報研究科, 教授 2012 – 2013 : 岐阜大学, その他の研究科, 教授 2011 – 2012 : 岐阜大学, 大学院・連合創薬医療情報研究科, 教授 2012 : 岐阜大学, 大学院連合創薬医療情報研究科, 教授 … More
Research Field	Principal Investigator General physiology Except Principal Investigator Biophysics / Biophysics / General physiology / Otorhinolaryngology / Virology / Applied veterinary science / Structural biochemistry / Lifelong developmental nursing / Structural biochemistry
Keywords	Principal Investigator プリオン / NMR / SPM / fMRI / ダイナミクス / MTC / ラマンシフター / MTC-EPI / 認知 / 構造変換 … More Except Principal Investigator プリオン / NMR / MRI / 蛋白質 / βラクトグロブリン / 創薬 / Functional MRI / functional MRI / PrP106-126 / 高圧NMR / メタノール資化酵母 / リゾチーム / Protein / プリオン病 / DSC / 安定同位体標識蛋白質 / 構造変換 / オリゴマー / 核磁気共鳴 / 立体構造 / 揺らぎ / BSE / フォールディング反応 / 大脳活動 / アミロイド / prion / fMRI / ダイナミクス / MTC / 視覚刺激 / 変性 / 温度刺激 / dynamic recognition / 実態調査 / 混合器 / 免疫 / スクレイピー型 / βシート / 【^1H】-NMR / 体内伝播 / EPI / metastable intermediate / タスク系列 / Yeast / brain function / 迷走神経 / ナノ秒分光 / CPMG relaxation / スクレイピー / BOLD効果 / drug discovery / BOLD effect / β-Lactoglobulin / Fluorescence / brain activity visual stimulation / NMR緩和時間 / high-pressure NMR / プリオン蛋白質 / α-β転移 / 脳機能イメージング / 交差緩和時間 / N-A異性化反応 / protein dynamics / 励起中間体 / 疎水性クラスター / Protein Folding / 合成高分子ゲル / unfrozen water / Mouse / 構造形成過程 / β2ミクログロブリン / 数論 / 活性化 / マウス / beta-Lactoglobulin / Scrapie / Immunology / recognition / 回腸遠位部 / Molecular Volume / α→β転移 / めまい / Ileum / 空間識失認 / free water / 異常立体構造変換反応 / Plasma Albumin / 活性型立体構造 / アミロイド病 / FOP / 生命科学理論 / 不凍水 / パルス・ラベル / マイクロ流路 / conformation / Prion / magnetization transfer / 分子内SH,S-S交換反応 / 立体構造進化 / causative mutation / 準安定状態 / 質的研究 / Nerve / 緩和時間 / 部分ペプチド / amyloid / 分子容 / 脳機能 / 運動認知 / 細菌毒性 / Transport / N A Isomerization / 温度ジャンプ / 分子老化現象 / 自己複製 / 赤外吸収 / 遺伝子改変マウス / isotope labeled protein / 水和 / Amyloid Fibril / ポリスレオニン / prion diseases / visual stimulation / Cross-Relaxation / 小児看護学 / 中間体 / ユビキチン / 認識 / restricted water / ブリオン / 病態 / パルスラベル / <^1H> -NMR / フォールディング / 抗体 / 分子内構造ゆらぎ / β2-Microglobulin / 磁化移動 / 束縛水 / 米国 / alpha*beta transition / number theory / will / 超高速パルスラベル / キネティクス / トレース公式 / lysozyme / 認知 / Vertigo / 高圧ジャンプ / 海綿状変性 / spatial disorientation / Protein folding / 感覚混乱 / Heteronuclear NMR / task sequence / 空間失認 / 安定性 / 抗プリオン化合物 / 高圧 / cerebral activity / プリオン蛋白 / Molecular Ageing / 遅い構造揺らぎ / Single Molecule Analysis / 意志 / 細胞内立体構造 / 国際情報交換 / synthetic copolymer gels / 遺伝子 / Denaturation / 空間認知 / high-pressure / prion strain / 神経 / 自由水 / SBDD / Intramolecular SH, S-S Exchange Reaction / プリオン類似蛋白 / ミリ秒揺らぎ / 視運動刺激 / spatial recognition / 血漿アルブミン / in vivo NMR Less

マイクロ流路超高速パルスラベルNMR装置の開発及びプリオン自己複製過程の解明Principal InvestigatorOngoing
- Principal Investigator
  
  桑田一夫
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Gifu University
Inhibition of a prion conversion by suppressing protein fluctuations using small-molecules
- Principal Investigator
  
  KAMATARI Yuji O.
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Gifu University
Experimental analysis of conformational evolution process of a prion by developing the kinetic NMRPrincipal Investigator
- Principal Investigator
  
  KUWATA Kazuo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  Gifu University
プリオン天然変性部位の異常立体構造変換における役割Principal Investigator
- Principal Investigator
  
  桑田一夫
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Gifu University
COMPREHENSIVE HOME CARE OF CHILDREN WITH FOP (Fibrodysplasia Ossificans Progressiva)
- Principal Investigator
  
  KUWATA Hiromi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Lifelong developmental nursing
- Research Institution
  Shiga University of Medical Science
細胞内プリオンタンパク質の立体構造、ダイナミクス、及び立体構造変換反応の解明Principal Investigator
- Principal Investigator
  
  桑田一夫
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
原子分解能かつナノ秒時間分解能でのプリオン・フォールディング反応の観測Principal Investigator
- Principal Investigator
  
  桑田一夫
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
プリオン部分ペプチドが作るオリゴマーの立体構造決定Principal Investigator
- Principal Investigator
  
  桑田一夫
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
STUDY ON THE NERVE-IMMUNE SYSTEMS AND CELLULAR FACTORS INFLUENCE TO THE PATHOGENICTTY AND DISTRIBUTION OF PRP^<Sc>IN ANIMAL PRION DISEASES
- Principal Investigator
  
  ISHIGURO Naotaka
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Gifu University
核磁気共鳴法を用いた新しい抗プリオン薬開発戦略の確立Principal Investigator
- Principal Investigator
  
  桑田一夫
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
温度ジャンプによるプリオン中間体形成反応の速度論的解析Principal Investigator
- Principal Investigator
  
  桑田一夫
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
Structure-based drug designs for the treatment of prion disease
- Principal Investigator
  
  KATAMINE Shigeru
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Virology
- Research Institution
  Nagasaki University
プリオン活性型立体構造に基づくプリオン病予防・治療薬の開発Principal Investigator
- Principal Investigator
  
  桑田一夫
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
New Concept on the Phase Space of the Protein : Experiments and TheoryPrincipal Investigator
- Principal Investigator
  
  KUWATA Kazuo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  Gifu University
Study on the cerebral activity for the visual disorientation of the spatial movement by functional MRI
- Principal Investigator
  
  MIZUTA Keisuke
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Gifu University
Development of a high-pressure treatment for amyloidosis
- Principal Investigator
  
  TACHIBANA Hideki, 赤坂一之
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kobe University
Magnetic resonance imaging of bound water in biological systems and its clinical applications.
- Principal Investigator
  
  ERA Seiichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Gifu University
Study on the cerebral activity for the visual recognition of the spatial movement by functional MRI
- Principal Investigator
  
  MIZUTA Keisuke, 久世文也
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Gifu University
Role of α-β transition in the folding of proteins
- Principal Investigator
  
  GOTO Yuji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biophysics
- Research Institution
  Osaka University
A STUDY ON THE TEMPORAL CORRELATIONS OF THE FUNCTIONAL BRAIN AREAS USING FUNCTIONAL MRIPrincipal Investigator
- Principal Investigator
  
  KUWATA Kazuo
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  GIFU UNIVERSITY
パルスデザインによる蛋白質分子内部運動の解析Principal Investigator
- Principal Investigator
  
  桑田一夫
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
Folding Mechanism of beta-Lactogobulin
- Principal Investigator
  
  GOTO Yuji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Biophysics
- Research Institution
  Osaka University
Direct detection of brain function using magnetic resonance imagingPrincipal Investigator
- Principal Investigator
  
  KUWATA Kazuo
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Gifu University
モルテン・グロビュール状態における分子内運動のO-ROESY法による研究Principal Investigator
- Principal Investigator
  
  桑田一夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
Intramolecular SH, S-S exchange reaction (molecular ageing) of bovine mercaptalbumin (BMA) in neutral pH region.
- Principal Investigator
  
  SOGAMI Masaru
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Gifu University

[Book] プリオン病と遅発性ウイルス感染症(正常および異常プリオン蛋白の構造)2010
- Author(s)
  桑田一夫
- Publisher
  金原出版株式会社
- Data Source
  KAKENHI-PUBLICLY-22113509
[Book] ウイルスハンドブックNo.16中枢神経系ウイルスウイルスハンドブック2008
- Author(s)
  桑田一夫
- Publisher
  株式会社日本医学館
- Data Source
  KAKENHI-PROJECT-20059016
[Book] 論理的創薬入門2006
- Author(s)
  桑田一夫編著
- Total Pages
  283
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-17028019
[Book] 論理的創薬入門2006
- Author(s)
  桑田一夫編著
- Total Pages
  283
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-18031015
[Book] 論理的創薬入門-構造生物学に基づくアプローチ2006
- Author(s)
  桑田一夫
- Total Pages
  276
- Publisher
  共立出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209017
[Book] 論理的創薬入門-構造生物学に基づくアプローチ2006
- Author(s)
  桑田一夫
- Total Pages
  276
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-16209017
[Book] PRIONS ; Food and Drug Safety.2005
- Author(s)
  Kazuo Kuwata
- Total Pages
  272
- Publisher
  Springer-Verlag Tokyo
- Data Source
  KAKENHI-PROJECT-16041218
[Book] タンパク質科学-構造・物性・機能-2005
- Author(s)
  桑田一夫
- Total Pages
  606
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-16041218
[Book] タンパク質科学-構造・物性・機能-2005
- Author(s)
  桑田一夫
- Total Pages
  606
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-17028019
[Book] PRIONS ; Food and Drug Safety.2005
- Author(s)
  Kazuo Kuwata
- Total Pages
  272
- Publisher
  Springer-Verlag Tokyo
- Data Source
  KAKENHI-PROJECT-17028019
[Book] タンパク質科学-構造・物性・機能-2005
- Author(s)
  桑田一夫
- Total Pages
  606
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-16017238
[Book] PRIONS ; Food and Drug Safety.2005
- Author(s)
  Kazuo Kuwata
- Total Pages
  272
- Publisher
  Springer-Verlag Tokyo
- Data Source
  KAKENHI-PROJECT-16017238
[Book] Semi-classical Quantization of Protein Dynamics : Novel NMR Relaxation Formalism and its Application to Prion.2005
- Author(s)
  Kazuo Kuwata
- Publisher
  Springer-Verlag (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Book] Splinger-Verlag Tokyo, PRIONS ; Food and Drug Safety (Ed: T Kitamoto)2005
- Author(s)
  Kuwata K et al.
- Publisher
  Semi-classical quantization of protein dynamics : novel NMR relaxation formalism and its application to prion.
- Data Source
  KAKENHI-PROJECT-16209017
[Book] The Impact of "Prion", on infectious particle of BSE., Hiroaki Okuda, Food Safety that supports the longevity.2004
- Author(s)
  Kazuo Kuwata
- Publisher
  Tokyo Kyoiku Joho Center
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Book] Semi-classical Quantization of Protein Dynamics : Novel NMR Relaxation Formalism and its Application to Prion.
- Author(s)
  Kazuo Kuwata
- Publisher
  Springer-Verlag (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] Synthesis of double-fluorescent labeled prion protein for FRET analysis2015
- Author(s)
  Hosokawa-Muto, Junji; Yamaguchi, Kei-ichi; KAMATARI, Yuji; Kuwata, Kazuo
- Journal Title
  
  Biosci Biotechnol Biochem.
  
  Volume : 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180
[Journal Article] Synthesis of double-fluorescent labeled prion protein for FRET analysis.2015
- Author(s)
  Hosokawa-Muto J, Yamaguchi K, Kamatari YO, Kuwata K.
- Journal Title
  
  Biosci Biotechnol Biochem.
  
  Volume : 79 Pages : 1802-1809
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07024, KAKENHI-PROJECT-26291011
[Journal Article] 研究と臨床をつなぐ―プリオン病治療薬開発における基礎から前臨床まで―2015
- Author(s)
  桑田一夫
- Journal Title
  
  医薬品医療機器レギュラトリーサイエンス
  
  Volume : Vol.46 No.7 Pages : 428-432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26291011
[Journal Article] 神経変性疾患と‘かたち’の制御2015
- Author(s)
  桑田一夫
- Journal Title
  
  Clinical Neuroscience月刊　臨床神経科学　言語の起源と脳の進化　Vol.33 8　962-963
  
  Volume : Vol.33 8 Pages : 962-963
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26291011
[Journal Article] Cryogenic coherent X-ray diffraction imaging biological non-crystalline particles using the KOTOBUKI-1 diffraction apparatus at SACLA2015
- Author(s)
  Oroguchi Tomotaka, Sekiguchi Yuki, Kobayashi Amane, Masaki Yu, Fukuda Asahi, Hashimoto Saki, Nakasako Masayoshi, Ichikawa Yuichi, Kurumizaka Hitoshi, Shimizu Mitsuhiro, Inui Yayoi, Matsunaga Sachihiro, Kato Takayuki, Namba Keiichi, Yamaguchi Keiichi, Kuwata Kazuo, Kameda Hiroshi, Fukui Naoya,
- Journal Title
  
  J. Phys. B.
  
  Volume : 48(18) Pages : 18400-18403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26291011
[Journal Article] A native-like intermediate serves as a branching point between the folding and aggregation pathways of the mouse prion protein2015
- Author(s)
  Honda RP, Xu M, Yamaguchi KI, Roder H, Kuwata K
- Journal Title
  
  Structure.
  
  Volume : 23(9) Pages : 1735-1742
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291011
[Journal Article] Logical design of anti-prion agents using NAGARA2015
- Author(s)
  Ma B, Yamaguchi K, Fukuoka M, Kuwata K
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume : 469(4): Pages : 930-935
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291011
[Journal Article] Synthesis and structure-activity relationship of 2-phenylimino chromene derivatives as inhibitors for aldo-keto reductase (AKR) 1B10、Bioorg2014
- Author(s)
  Satoshi Endo, Dawei Hu, Miho Suyama, Toshiyuki Matsunaga, Kenji Sugimoto, Yuji Matsuya, Ossama El-Kabbani, Kazuo Kuwata, Akira Hara, Yukio Kitade, Naoki Toyooka
- Journal Title
  
  Med. Chem
  
  Volume : vol21 Pages : 6378-6384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790114, KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-25460068
[Journal Article] Synthesis and structure-activity relationship of 2-phenylimino chromene derivatives as inhibitors for aldo-keto reductase (AKR) 1B10、Bioorg2014
- Author(s)
  Satoshi Endo, Dawei Hu, Miho Suyama, Toshiyuki Matsunaga, Kenji Sugimoto, Yuji Matsuya, Ossama El-Kabbani, Kazuo Kuwata, Akira Hara, Yukio Kitade, Naoki Toyooka
- Journal Title
  
  Med. Chem
  
  Volume : vol21 Pages : 6378-6384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790114, KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-25460068
[Journal Article] Acid-induced Molten Globule State of a Prion Protein: Crucial Role of Strand 1-Helix 1-Strand 2 Segment.2014
- Author(s)
  Honda RP, Kei-ichi Yamaguchi, Kuwata K.
- Journal Title
  
  The Journal of biological chemistry.
  
  Volume : 289(44) Pages : 30355-30363
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26291011
[Journal Article] A theoretical study of the two binding modes between lysozyme and tri-NAG with an explicit solvent model based on the fragment molecular orbital method2013
- Author(s)
  T. Ishikawa, R. R. Burri, Y. O. Kamatari, S. Sakuraba, N. Matubayasi, A. Kitao, and K. Kuwata
- Journal Title
  
  Phys. Chem. Chem. Phys
  
  Volume : 15 Pages : 3646-3654
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20118002, KAKENHI-PROJECT-21300111, KAKENHI-PROJECT-23370066, KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-23651202, KAKENHI-PROJECT-24570180
[Journal Article] A minimal implementation of the AMBER-PAICS interface for Ab initio FMO-QM/MM-MD simulation2013
- Author(s)
  Takuya Okamoto, Takeshi Ishikawa, Yoshiyuki Koyano, Norifumi Yamamoto, Kazuo Kuwata, Masataka Nagaoka
- Journal Title
  
  Bulletin of the Chemical Society of Japan
  
  Volume : 86(2) Pages : 210-222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-23770175, KAKENHI-PROJECT-24654137
[Journal Article] Protein-Specific Force Field Derived from the Fragment Molecular Orbital Method can Improve Protein-Ligand Binding Interactions2013
- Author(s)
  L. Chang, T. Ishikawa, K. Kuwata, and S. Takada
- Journal Title
  
  J. Comp. Chem
  
  Volume : vol. 34 Pages : 1251-1257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370057, KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-25251019
[Journal Article] Free-energy analysis of lysozyme-triNAG binding modes with all-atom molecular dynamics simulation combined with the solution theory in the energy representation2013
- Author(s)
  K. Takemura, R. R. Burri, T. Ishikawa, T. Ishikura, S. Sakuraba, N. Matubayasi, K. Kuwata, and A. Kitao
- Journal Title
  
  Chem. Phys. Lett
  
  Volume : 559 Pages : 94-98
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20118002, KAKENHI-PROJECT-21300111, KAKENHI-PROJECT-23370066, KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-23651202
[Journal Article] Characterizing antiprion compounds based on their binding properties to prion proteins : Implications as medical chaperones2013
- Author(s)
  Yuji Kamatari, Yosuke Hayano,, Kei-ichi Yamaguchi, Junji Hosokawa-Muto, Kazuo Kuwata
- Journal Title
  
  Protein Science
  
  Volume : 22(1) Pages : 22-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-10J05602
[Journal Article] Nearly Reversible Conformational Change of Amyloid Fibrils as Revealed by pH-Jump Experiments2013
- Author(s)
  Kei-ichi Yamaguchi, Yuji O. Kamatari, Mayuko Fukuoka, Reiji Miyaji, Kazuo Kuwata
- Journal Title
  
  Biochemistry
  
  Volume : 52(39) Pages : 6797-6806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-24570180
[Journal Article] FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice2013
- Author(s)
  Nakagaki T, Satoh K, Ishibashi D, Fuse T, Sano K, Kamatari YO, Kuwata K, Shigematsu K, Iwamaru Y, Takenouchi T, Kitani H, Nishida N, Atarashi R.
- Journal Title
  
  Autophagy
  
  Volume : 9 Issue : 9 Pages : 1386-1394
- Publisher
  Landes Bioscience
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-24591482, KAKENHI-PROJECT-25461514
[Journal Article] Synthesis of an 11C-Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography2013
- Author(s)
  Tsutomu Kimura, Takeo Sako, Siqin, Junji Hosokawa-Muto, Yi Long Cui, Yasuhiro Wada, Yosky Kataoka, Hisashi Doi, Suehiro Sakaguchi, Masaaki Suzuki, Yasuyoshi Watanabe, Kazuo Kuwata
- Journal Title
  
  ChemMedChem
  
  Volume : 8(7) Pages : 1035-1039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-24659574, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460399
[Journal Article] Logical Design of Medical Chaperone for Prion Diseases2013
- Author(s)
  Kuwata Kazuo
- Journal Title
  
  Current topics in medicinal chemistry
  
  Volume : 13(19) Pages : 2432-2440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068
[Journal Article] Anti-prion activity of an RNA aptamer and its structural basis.2013
- Author(s)
  Mashima Tsukasa, Nishikawa Fumiko, Kamatari Yuji, Fujiwara Hiromichi, Saimura Masayuki, Nagata Takashi, Kodaki Tsutomu, Nishiwaka Satoshi, Kuwata Kazuo, Katahira Masato
- Journal Title
  
  Nucleic acids research
  
  Volume : 41 Issue : 2 Pages : 1355-1362
- Publisher
  Oxford University Press
- PMID
  23180780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-23570146, KAKENHI-PROJECT-23657072, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-25291013, KAKENHI-PROJECT-11J02435
[Journal Article] A theoretical study of the two binding modes between lysozyme and tri-NAG with an explicit solvent model based on the fragment molecular orbital method2013
- Author(s)
  T. Ishikawa, R. R. Burri, Y. O. Kamatari, S. Sakuraba, N. Matubayasi, A. Kitao, and K. Kuwata
- Journal Title
  
  Phys. Chem. Chem. Phys
  
  Volume : 15 Pages : 3646-3654
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20118002, KAKENHI-PROJECT-21300111, KAKENHI-PROJECT-23370066, KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-23651202, KAKENHI-PROJECT-24570180
[Journal Article] Logical design of medical chaperone for prion diseases2013
- Author(s)
  Kuwata K.
- Journal Title
  
  Curr Top Med Chem.
  
  Volume : 13 Pages : 2432-2440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180
[Journal Article] Characterizing antiprion compounds based on their binding properties to prion proteins : Implications as medical chaperones2013
- Author(s)
  Yuji Kamatari, Yosuke Hayano,, Kei-ichi Yamaguchi, Junji Hosokawa-Muto, Kazuo Kuwata
- Journal Title
  
  Protein Science
  
  Volume : 22(1) Pages : 22-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-10J05602
[Journal Article] Nearly Reversible Conformational Change of Amyloid Fibrils as Revealed by pH-Jump Experiments2013
- Author(s)
  Kei-ichi Yamaguchi, Yuji O. Kamatari, Mayuko Fukuoka, Reiji Miyaji, Kazuo Kuwata
- Journal Title
  
  Biochemistry
  
  Volume : 52(39) Pages : 6797-6806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-24570180
[Journal Article] FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice2013
- Author(s)
  Nakagaki T, Satoh K, Ishibashi D, Fuse T, Sano K, Kamatari YO, Kuwata K, Shigematsu K, Iwamaru Y, Takenouchi T, Kitani H, Nishida N, Atarashi R.
- Journal Title
  
  Autophagy
  
  Volume : 9 Issue : 9 Pages : 1386-1394
- Publisher
  Landes Bioscience
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-24591482, KAKENHI-PROJECT-25461514
[Journal Article] Synthesis of an 11C-Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography2013
- Author(s)
  Tsutomu Kimura, Takeo Sako, Siqin, Junji Hosokawa-Muto, Yi Long Cui, Yasuhiro Wada, Yosky Kataoka, Hisashi Doi, Suehiro Sakaguchi, Masaaki Suzuki, Yasuyoshi Watanabe, Kazuo Kuwata
- Journal Title
  
  ChemMedChem
  
  Volume : 8(7) Pages : 1035-1039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-24659574, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460399
[Journal Article] Anti-prion activity of an RNA aptamer and its structural basis.2013
- Author(s)
  Mashima Tsukasa, Nishikawa Fumiko, Kamatari Yuji, Fujiwara Hiromichi, Saimura Masayuki, Nagata Takashi, Kodaki Tsutomu, Nishiwaka Satoshi, Kuwata Kazuo, Katahira Masato
- Journal Title
  
  Nucleic acids research
  
  Volume : 41 Issue : 2 Pages : 1355-1362
- Publisher
  Oxford University Press
- PMID
  23180780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-23570146, KAKENHI-PROJECT-23657072, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-25291013, KAKENHI-PROJECT-11J02435
[Journal Article] 量子創薬　論理的形態制御学の原理2012
- Author(s)
  桑田一夫
- Journal Title
  
  藥學雜誌 = Journal of the Pharmaceutical Society of Japan
  
  Volume : 132 Issue : 8 Pages : 873-879
- Publisher
  公益社団法人日本薬学会
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068
[Journal Article] Structure-based discovery of anti-influenza virus A compounds among medicines2012
- Author(s)
  Fukuoka M., et al.
- Journal Title
  
  Biochim.Biophys.Acta.
  
  Volume : 1820 Pages : 90-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249025, KAKENHI-PROJECT-21570163, KAKENHI-PUBLICLY-22113509, KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-09J00964
[Journal Article] Respiratory and cardiovascular toxicity studies of a novel anti-prion compound, GN8, in rats and dogs2012
- Author(s)
  Junji-Hosokawa Muto, Tsutomu Kimura, Kazuo Kuwata
- Journal Title
  
  Drug and Chemical Toxicology
  
  Volume : 35(3) Pages : 264-271
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509, KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-21570163
[Journal Article] Identification of a novel compound with antiviral activity against influenza A virus depending on PA subunit of viral RNA polymerase2012
- Author(s)
  Yamada K, Koyama H, Hagiwara K, Ueda A, Sasaki Y, Kanesashi SN, Ueno R, Nakamura HK, Kuwata K, Shimizu K, Suzuki M, Aida Y
- Journal Title
  
  Microbes and infection/Institut Pasteur
  
  Volume : 14(9) Pages : 740-747
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509, KAKENHI-PROJECT-23370068
[Journal Article] RI-MP2 Gradient Calculation of Large Molecules Using the Fragment Molecular Orbital Method2012
- Author(s)
  Ishikawa Takeshi, Kuwata Kazuo
- Journal Title
  
  Journal of Physical Chemistry Letters
  
  Volume : 3(3) Pages : 375-379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068, KAKENHI-PUBLICLY-22113509
[Journal Article] Proper calibration of ultrasonic power enabled the quantitative analysis of the ultrasonication-induced amyloid formation process2012
- Author(s)
  Keiichi Yamaguchi, Tomoharu Matsumoto, Kazuo Kuwata
- Journal Title
  
  Protein Science
  
  Volume : 21(1) Pages : 38-49
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509, KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-10J05602
[Journal Article] Structure-based discovery of anti-influenza virus A compounds among medicines2012
- Author(s)
  Fukuoka M., et al.
- Journal Title
  
  Biochim.Biophys.Acta.
  
  Volume : 1820 Pages : 90-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249025, KAKENHI-PROJECT-21570163, KAKENHI-PUBLICLY-22113509, KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-09J00964
[Journal Article] Respiratory and cardiovascular toxicity studies of a novel anti-prion compound, GN8, in rats and dogs2012
- Author(s)
  Junji-Hosokawa Muto, Tsutomu Kimura, Kazuo Kuwata
- Journal Title
  
  Drug and Chemical Toxicology
  
  Volume : 35(3) Pages : 264-271
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509, KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-21570163
[Journal Article] Identification of a novel compound with antiviral activity against influenza A virus depending on PA subunit of viral RNA polymerase2012
- Author(s)
  Yamada K, Koyama H, Hagiwara K, Ueda A, Sasaki Y, Kanesashi SN, Ueno R, Nakamura HK, Kuwata K, Shimizu K, Suzuki M, Aida Y
- Journal Title
  
  Microbes and infection/Institut Pasteur
  
  Volume : 14(9) Pages : 740-747
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509, KAKENHI-PROJECT-23370068
[Journal Article] RI-MP2 Gradient Calculation of Large Molecules Using the Fragment Molecular Orbital Method2012
- Author(s)
  Ishikawa Takeshi, Kuwata Kazuo
- Journal Title
  
  Journal of Physical Chemistry Letters
  
  Volume : 3(3) Pages : 375-379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068, KAKENHI-PUBLICLY-22113509
[Journal Article] Proper calibration of ultrasonic power enabled the quantitative analysis of the ultrasonication-induced amyloid formation process2012
- Author(s)
  Keiichi Yamaguchi, Tomoharu Matsumoto, Kazuo Kuwata
- Journal Title
  
  Protein Science
  
  Volume : 21(1) Pages : 38-49
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509, KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-10J05602
[Journal Article] フラグメント分子軌道法プログラム「PAICS」と統合創薬プログラム「NAGARA」2011
- Author(s)
  石川岳志, 石倉孝一, 桑田一夫
- Journal Title
  
  Molecular Science
  
  Volume : 5
- URL
  http://j-molsci.jp/article/2011_1.html
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068
[Journal Article] Synthesis of 9-substituted 2,3,4,9-tetrahydro-1H-carbazole derivatives and evaluation of their anti-prion activity in TSE-infected cells2011
- Author(s)
  Kimura T, Hosokawa-Muto J, Asami K, Murai T, Kuwata K
- Journal Title
  
  Eur.J.Med.Chem.
  
  Volume : 46 Pages : 5675-5679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570163, KAKENHI-PUBLICLY-22113509, KAKENHI-PROJECT-23370068
[Journal Article] Deciphering the Molecular Details for the Binding of the Prion Protein to Main Ganglioside GM1 of Neuronal Membranes2011
- Author(s)
  Sanghera N, Correia BE, Correia JR, Ludwig C, Agarwal S, Nakamura HK, Kuwata K, Samain E, Gill AC, Bonev BB, Pinheiro TJ
- Journal Title
  
  Chemistry & biology
  
  Volume : 18(11) Pages : 1422-31
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509, KAKENHI-PROJECT-23370068
[Journal Article] Synthesis of 9-substituted 2,3,4,9-tetrahydro-1H-carbazole derivatives and evaluation of their anti-prion activity in TSE-infected cells2011
- Author(s)
  Kimura T, Hosokawa-Muto J, Asami K, Murai T, Kuwata K
- Journal Title
  
  Eur.J.Med.Chem.
  
  Volume : 46 Pages : 5675-5679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570163, KAKENHI-PUBLICLY-22113509, KAKENHI-PROJECT-23370068
[Journal Article] Deciphering the Molecular Details for the Binding of the Prion Protein to Main Ganglioside GM1 of Neuronal Membranes2011
- Author(s)
  Sanghera N, Correia BE, Correia JR, Ludwig C, Agarwal S, Nakamura HK, Kuwata K, Samain E, Gill AC, Bonev BB, Pinheiro TJ
- Journal Title
  
  Chemistry & biology
  
  Volume : 18(11) Pages : 1422-31
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509, KAKENHI-PROJECT-23370068
[Journal Article] フラグメント分子軌道法プログラム「PAICS」と統合創薬プログラム「NAGARA」2011
- Author(s)
  石川岳志, 石倉孝一, 桑田一夫
- Journal Title
  
  Molecular Science
  
  Volume : 5
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509
[Journal Article] Synthesis of GN8 derivatives and evaluation of their antipri on activity in TSE-infected cells.2011
- Author(s)
  T.Kimura, J.Hosokawa-Muto, Yuji O.Kamatari, K.Kuwata
- Journal Title
  
  Bioorg.Med.Chem.Lett.
  
  Volume : 21 Pages : 1502-1507
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509
[Journal Article] Caffeoylquinic acids are major constituents with potent anti-influenza effects in Brazilian green Propolis water extract2011
- Author(s)
  T.Urushisaki, T.Takemura, S.Tazawa, M.Fukuoka, J.Hosokawa-Muto, Y.Araki, K.Kuwata
- Journal Title
  
  ECAM
  
  Volume : (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509
[Journal Article] Acceleration of monomer self-consistent charge process in fraement molecular orbital method.2010
- Author(s)
  Ishikawa T, Kuwata K.
- Journal Title
  
  Chem-Bio Informatics Journal 10
  
  Pages : 24-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059016
[Journal Article] Interaction analysis of the native structure of prion protein with quantum chemical calculations.2010
- Author(s)
  Ishikawa T, Kuwata K.
- Journal Title
  
  Journal of Chemical Theory and Computation 6
  
  Pages : 538-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059016
[Journal Article] Partial energy gradient based on the fragment molecular orbital menthod : application to geometry optimization2010
- Author(s)
  Takeshi Ishikawa, Norifumi Yamamoto, Kazuo Kuwata
- Journal Title
  
  Chemical Physics Letters
  
  Volume : 500 Pages : 149-154
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509
[Journal Article] Interaction Analysis of the Native Structure of Prion Protein with Quantum Chemical Calculations.2010
- Author(s)
  Takeshi Ishikawa, Kazuo Kuwata
- Journal Title
  
  J.Chem.Theory Comput.
  
  Volume : 6 Pages : 538-547
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509
[Journal Article] Redox behaviors of the neurotoxic portion in human Prion protein, HuPrP (106-126)2010
- Author(s)
  N.Yamamoto, K.Kuwata
- Journal Title
  
  Chemical Physics Letters
  
  Volume : 498 Pages : 184-187
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509
[Journal Article] Accerelation of monomer self-consistent charge process in fragment molecular orbital method.2010
- Author(s)
  Takeshi Ishikawa, Kazuo Kuwata
- Journal Title
  
  Chem-Bio Inform.J.
  
  Volume : 10 Pages : 24-31
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509
[Journal Article] Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B102010
- Author(s)
  Satoshi Endo, Toshiyuki Matsunaga, Kazuo Kuwata, Hai-Tao Zhao, Ossama El-Kabbani, Yukio Kitade, Akira Hara
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume : 18 Pages : 2485-2490
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113509
[Journal Article] Novel anti-cancer compounds : structure-based discovery of chemical chaperons for p53.2009
- Author(s)
  Okuda Y, Nakamura HK, Kuwata K.
- Journal Title
  
  Oncology reports 22
  
  Pages : 739-744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059016
[Journal Article] Regulating the Conformation of Prion Protein through Ligand Binding.2009
- Author(s)
  Yamamoto N, Kuwata K.
- Journal Title
  
  Journal of Physical Chemistry B 113
  
  Pages : 12853-12856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059016
[Journal Article] 患者に利する創薬2009
- Author(s)
  桑田一夫
- Journal Title
  
  週刊日本医事新報 4453(●)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059016
[Journal Article] Difference in redox behaviors between copper-binding octarepeat and nonoctarepeat sites in prion protein.2009
- Author(s)
  Yamamoto N, Kuwata K.
- Journal Title
  
  Journal of Biological Inorganic Chemistry 14
  
  Pages : 1209-1218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059016
[Journal Article] Comparative H-1 NMR studies on the structural looseness of the aged(A)and non-aged(N)bovine mercaptalbumin in the alkaline region2009
- Author(s)
  Era S, Sogami M, Kuwata K.
- Journal Title
  
  International Journal of Biological Macromolecules 44
  
  Pages : 37-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059016
[Journal Article] Theoretical study of the prion protein based on the fragment molecular orbital method.2009
- Author(s)
  Ishikawa T, Ishikura T, Kuwata K.
- Journal Title
  
  Journal of Computational Chemistry 30
  
  Pages : 2594-2601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059016
[Journal Article] Fragment molecular orbital calculation using the RI-MP2 method.2009
- Author(s)
  Ishikawa T, Kuwata K.
- Journal Title
  
  Chemical Physics Letters 474
  
  Pages : 195-198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059016
[Journal Article] Cold destabilization and temperature jump of the murine prion protein mPrP(23-231)2009
- Author(s)
  Matsumoto T, Nakagawa T, Kuwata K.
- Journal Title
  
  Biochimica et Biophysica Acta Proteins and Proteomics. 1794
  
  Pages : 669-673
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059016
[Journal Article] DFT studies on redox properties of copper-chelating cuprizone : Unusually high-valent copper(III)state.2009
- Author(s)
  Yamamoto N, Kuwata K.
- Journal Title
  
  Journal of Molecular Structure THEOCHEM 895
  
  Pages : 52-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059016
[Journal Article] プリオン2008
- Author(s)
  桑田一夫
- Journal Title
  
  蛋白質・核酸・酵素 53
  
  Pages : 991-991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059016
[Journal Article] プリオン病治療薬の論理的開発をめざして-蛋白質のダイナミクス解析から構造変換制御物質の探索へRational drug discovery for prion diseases-2008
- Author(s)
  桑田一夫
- Journal Title
  
  蛋白質核酸酵素 53
  
  Pages : 727-732
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059016
[Journal Article] ダイナミクスと安定性が交叉する領域の熱力学-量子暗号熱力学とプリオン-2008
- Author(s)
  桑田一夫
- Journal Title
  
  熱測定 35
  
  Pages : 140-147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059016
[Journal Article] アミロイドーシス発症の分子機構解明を目指して : 現状と展望、夢2007
- Author(s)
  後藤祐児, 桑田一夫, 関島良樹, 田中元雅, 内木宏延, 永井義隆, 松崎勝巳, 樋口京一
- Journal Title
  
  細胞工学 26
  
  Pages : 181-185
- Data Source
  KAKENHI-PROJECT-17028019
[Journal Article] プリオン病の発症と伝播機構2007
- Author(s)
  山口圭一, 松本友治, 児玉耕太, 岸直人, 桑田一夫
- Journal Title
  
  細胞工学 26
  
  Pages : 151-155
- Data Source
  KAKENHI-PROJECT-17028019
[Journal Article] Strange kinetic phase in the extremely early folding folding process of β-lactoglobulin2007
- Author(s)
  Yuji O.Kamatari, Hironori K.Nakamura, Kazuo Kuwata
- Journal Title
  
  FEBS Lett. 581
  
  Pages : 4463-4467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031015
[Journal Article] プリオン病の発症と伝播機構2007
- Author(s)
  山口圭一, 松本友治, 児玉耕太, 岸直人, 桑田一夫
- Journal Title
  
  細胞工学 26
  
  Pages : 151-155
- Data Source
  KAKENHI-PROJECT-18031015
[Journal Article] Species specific differences in the intermediate states of human and hamster prion protein detected by high pressure NMR spectroscopy.2007
- Author(s)
  Werner Kremer, Norman Kachel, Kazuo Kuwata, Kazuyuki Akasaka, Hans Robert Kalbitzer
- Journal Title
  
  J.Biol.Chem. 282
  
  Pages : 22689-22698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031015
[Journal Article] アミロイドーシス発症の分子機構解明を目指して : 現状と展望、夢2007
- Author(s)
  後藤祐児, 桑田一夫, 関島良樹, 田中元雅, 内木宏延, 永井義隆, 松崎勝巳, 樋口京一
- Journal Title
  
  細胞工学 26
  
  Pages : 181-185
- Data Source
  KAKENHI-PROJECT-18031015
[Journal Article] Hot spots in prion protein for pathogenic conversion2007
- Author(s)
  Kazuo Kuwata, (以下13名)
- Journal Title
  
  Proc.Natl.Acad.Sci.U.S.A. 104
  
  Pages : 11921-11926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031015
[Journal Article] Modeling of a propagation mechanism of infectious prion protein; a hexamer as the minimum infectious unit2007
- Author(s)
  Nakamura HK, Takano M, Kuwata K
- Journal Title
  
  Biochem.Biophys.Res.Commun 361
  
  Pages : 789-793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031015
[Journal Article] バイオインフォーマティクスによるプリオン病治療薬の開発2006
- Author(s)
  桑田一夫
- Journal Title
  
  化学療法の領域 22(1)
  
  Pages : 87-93
- Data Source
  KAKENHI-PROJECT-16041218
[Journal Article] Effect of Hunter disease (mucopoly saccharidosis type II) mutations on molecular phenotypes of iduronate-2-sulfatase2006
- Author(s)
  K.Sukegawa-Hayasaka, Z.Kato, H.Nakamura, S.Tomatsu, T.Fukao, K.Kuwata, T.Orii, N.Kondo
- Journal Title
  
  J Inherit Metab Dis 29
  
  Pages : 755-761
- Data Source
  KAKENHI-PROJECT-17028019
[Journal Article] バイオインフォーマティクスによるプリオン病治療薬の開発2006
- Author(s)
  桑田一夫
- Journal Title
  
  化学療法の領域 22(1)
  
  Pages : 87-93
- Data Source
  KAKENHI-PROJECT-17028019
[Journal Article] Pathogenic role of B cells in anti-CD40 caused necroinflammatory liver disease2006
- Author(s)
  K.Kimura, H.Moriwaki, M.Nagaki, M.Saio, Y.Nakamoto, M.Naito, K.Kuwata, F.V.Chisari
- Journal Title
  
  Am. J. Pathol 168(3)
  
  Pages : 786-795
- Data Source
  KAKENHI-PROJECT-17028019
[Journal Article] バイオインフォーマティクスによるプリオン病治療薬の開発2006
- Author(s)
  桑田一夫
- Journal Title
  
  化学療法の領域 22(1)
  
  Pages : 87-93
- Data Source
  KAKENHI-PROJECT-16017238
[Journal Article] Effect of Hunter disease (mucopoly saccharidosis type II) mutations on molecular phenotypes of iduronate-2-sulfatase2006
- Author(s)
  K.Sukegawa-Hayasaka, Z.Kato, H.Nakamura, S.Tomatsu, T.Fukao, K.Kuwata, T.Orii, N.Kondo
- Journal Title
  
  J Inherit Metab Dis 29
  
  Pages : 755-761
- Data Source
  KAKENHI-PROJECT-18031015
[Journal Article] Pathogenic role of B cells in anti-CD40 caused necroinflammatory liver disease2006
- Author(s)
  K.Kimura, H.Moriwaki, M.Nagaki, M.Saio, Y.Nakamoto, M.Naito, K.Kuwata, F.V.Chisari
- Journal Title
  
  Am. J. Pathol 168(3)
  
  Pages : 786-795
- Data Source
  KAKENHI-PROJECT-18031015
[Journal Article] 素数とプリオン 21世紀における生命科学の新表現理論への挑戦2005
- Author(s)
  桑田一夫
- Journal Title
  
  数理科学 499
  
  Pages : 45-53
- Data Source
  KAKENHI-PROJECT-16041218
[Journal Article] 素数とプリオン 21世紀における生命科学の新表現理論への挑戦2005
- Author(s)
  桑田一夫
- Journal Title
  
  数理科学 499
  
  Pages : 45-53
- Data Source
  KAKENHI-PROJECT-16017238
[Journal Article] Prime Number and Prion--A challenge to discover the new representation theory of life science at 21^<st> century.2005
- Author(s)
  Kazuo Kuwata
- Journal Title
  
  Mathematical Sciences 43(1)
  
  Pages : 45-53
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] 素数とプリオン--21世紀における生命科学の新表現理論への挑戦2005
- Author(s)
  桑田一夫
- Journal Title
  
  数理科学 43
  
  Pages : 45-53
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] 素数とプリオン 21世紀における生命科学の新表現理論への挑戦2005
- Author(s)
  桑田一夫
- Journal Title
  
  数理科学 499
  
  Pages : 45-53
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] プリオン中間体と治療薬開発分子感染機構と創薬制御2004
- Author(s)
  桑田一夫
- Journal Title
  
  蛋白質核酸酵素 49(7)
  
  Pages : 1110-1112
- Data Source
  KAKENHI-PROJECT-16041218
[Journal Article] Slow Conformational Dynamics in the Hamster Prion Protein2004
- Author(s)
  Kazuo Kuwata
- Journal Title
  
  Biochemistry 43(15)
  
  Pages : 4439-4446
- Data Source
  KAKENHI-PROJECT-16041218
[Journal Article] Slow Conformational Dynamics in the Hamster Prion Protein2004
- Author(s)
  Kazuo Kuwata
- Journal Title
  
  Biochemistry 43(15)
  
  Pages : 4439-4446
- Data Source
  KAKENHI-PROJECT-16017238
[Journal Article] プリオン中間体と治療薬開発分子感染機構と創薬制御2004
- Author(s)
  桑田一夫
- Journal Title
  
  蛋白質核酸酵素 49(7)
  
  Pages : 1110-1112
- Data Source
  KAKENHI-PROJECT-16017238
[Journal Article] プリオン中間体と治療薬開発分子感染機構と創薬制御2004
- Author(s)
  桑田一夫
- Journal Title
  
  蛋白質核酸酵素 49(7)
  
  Pages : 1110-1112
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] Intermediate conformer of prion and dynamics based drug design (DBDD).2004
- Author(s)
  Kazuo Kuwata
- Journal Title
  
  Tanpakushitsu Kakusan Koso 49(7)
  
  Pages : 1110-1112
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] Slow conformational dynamics in the hamster prion protein.2004
- Author(s)
  Kazuo Kuwata
- Journal Title
  
  Biochemistry 43(15)
  
  Pages : 4439-4446
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] Slow conformational dynamics in the hamster prion protein.2004
- Author(s)
  Kazuo Kuwata
- Journal Title
  
  Biochemistry 43
  
  Pages : 4439-4446
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] プリオン中間体と治療薬開発--分子感染機構と創薬制御2004
- Author(s)
  桑田一夫
- Journal Title
  
  蛋白質核酸酵素 49
  
  Pages : 1110-1112
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] Slow Conformational Dynamics in the Hamster Prion Protein2004
- Author(s)
  Kazuo Kuwata
- Journal Title
  
  Biochemistry 43(15)
  
  Pages : 4439-4446
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] Slow conformational dynamics in the hanster prion protein.2004
- Author(s)
  Kuwata K et al.
- Journal Title
  
  Biochemistry 43
  
  Pages : 4439-4446
- Data Source
  KAKENHI-PROJECT-16209017
[Journal Article] たんぱく質の"かたち"の変貌と神経変性疾患2003
- Author(s)
  桑田一夫
- Journal Title
  
  日本医事新報 4123
  
  Pages : 19-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] Conformational change of the protein structure and neurodegenerative diseases.2003
- Author(s)
  Kazuo Kuwata
- Journal Title
  
  Nippon Iji Shinpo 4123
  
  Pages : 19-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril formation of prion protein fragment 106-126.2003
- Author(s)
  Kazuo Kuwata
- Journal Title
  
  Proc.Natl.Acad.Sci.U.S.A. 100
  
  Pages : 14790-14795
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] An emerging concept of biomolecular dynamics and function : applications of NMR & MRI.2002
- Author(s)
  Kazuo Kuwata
- Journal Title
  
  Magn.Reson.Med.Sci. 1
  
  Pages : 27-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] Locally disordered conformer of the hamster prion protein : a crucial intermediate to PrPSc?2002
- Author(s)
  Kazuo Kuwata
- Journal Title
  
  Biochemistry 41
  
  Pages : 12277-12283
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] プリオン病の構造医学2002
- Author(s)
  桑田一夫
- Journal Title
  
  蛋白質・核酸・酵素 47
  
  Pages : 1292-1298
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] Locally disordered conformer of the hamster prion protein : a crucial intermediate to PrP^<Sc>?2002
- Author(s)
  Kazuo Kuwata
- Journal Title
  
  Biochemistry 41(41)
  
  Pages : 12277-12283
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] Structural medicine and structure-based drug design for prion diseases.2002
- Author(s)
  Kazuo Kuwata
- Journal Title
  
  Tanpakushitsu Kakusan Koso 47(10)
  
  Pages : 1292-1298
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Presentation] プリオン病治療薬の開発2016
- Author(s)
  桑田一夫
- Organizer
  第5回岐阜構造生物学・医学・論理的創薬研究シンポジウム
- Place of Presentation
  岐阜薬科大学、岐阜
- Year and Date
  2016-03-10
- Invited
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] ’A-state’ of PrP a branching point between the folding and misfolding pathways（ポスター）2015
- Author(s)
  Ryo P. Honda, Kazuo Kuwata
- Organizer
  APPS2015
- Place of Presentation
  石川音楽堂、石川県
- Year and Date
  2015-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] Continuous ultrasonication induces the rapid formation of mPrP aggregates（ポスター）2015
- Author(s)
  Kei-ichi Yamaguchi, Ryo P. Honda, Abdelazim Elsayed Elhelaly, Kazuo Kuwata
- Organizer
  APPS2015
- Place of Presentation
  石川音楽堂、石川県
- Year and Date
  2015-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] Elucidation of the pathogenic conversion mechanism of a prion protein, diagnosis and treatment（オーラル）2015
- Author(s)
  Kazuo Kuwata
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール、徳島県
- Year and Date
  2015-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] Toward a first in human trial of a medical chaperone for prion diseases（オーラル）2015
- Author(s)
  Kazuo Kuwata
- Organizer
  Therapeutic approaches to prion disease and other neurodegenerative conditions associated with protein misfolding
- Place of Presentation
  Cold Spring Harbor Laboratory, USA
- Year and Date
  2015-09-15
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] プリオン蛋白質のミスフォールディング過程におけるモルテングロビュール状態2015
- Author(s)
  桑田一夫、本田諒
- Organizer
  第四回岐阜構造生物学・医学・論理的創薬研究会シンポジウム
- Place of Presentation
  岐阜薬科大学
- Year and Date
  2015-03-05
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] Structural Characterization of Two Distinct Yeast Prion Protein Interaction（オーラル）2015
- Author(s)
  Toshinobu Shida, Yuji Kamatari, Yoshiki Yamagushi, Kazuo Kuwata, Motomasa Tanaka
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール、徳島県
- Year and Date
  2015-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] Strategy for elucidating abnormal structure od prion proteins using the double-fluorescent labeling method and FRET analysis（ポスター）2015
- Author(s)
  Yuji O.Kamatari, Junji Hosokawa-Muto, Kei-ichi Yamaguchi, Kazuo Kuwata
- Organizer
  APPS2015
- Place of Presentation
  石川音楽堂、石川県
- Year and Date
  2015-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] Toward the First in Human Clinical Trial of Medical Chaperone for Prion Diseases（オーラル）2015
- Author(s)
  桑田一夫
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ、ホテル日航新潟、新潟県
- Year and Date
  2015-05-20
- Invited
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] Molten globule state and misfolding of a prion protein（オーラル）2015
- Author(s)
  Kei-ichi Yamaguchi, Ryo P. Honda, Kazuo Kuwata
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール、徳島県
- Year and Date
  2015-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] プリオン病治験体制の整備2015
- Author(s)
  桑田一夫
- Organizer
  革新的医療研究開発で挑む神経変性疾患―プリオン病治験体制の確立に向けて―
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-02-14
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] XFEL低温コヒーレントX線回折イメージングによるアミロイド繊維凝集体の構造研究2015
- Author(s)
  真崎悠、小林周、関口優希、苙口友隆、中迫雅由、山口圭一、桑田一夫、亀田啓、福井直也、河田康志、高山裕貴、山本雅貴
- Organizer
  第28回日本放射光学会年会・放射光化学合同シンポジウム
- Place of Presentation
  立命館大学
- Year and Date
  2015-01-12
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] メディカルシャペロンによるプリオン病の治療2014
- Author(s)
  桑田一夫
- Organizer
  プリオンに関する講演会
- Place of Presentation
  臨床研究情報センター
- Year and Date
  2014-03-18
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Logical design of small molecules for the differentiation of induced pluripotent stem (iPS) cells2014
- Author(s)
  ワリード・オスマン, 桑田一夫
- Organizer
  第7回武田科学振興財団薬科学シンポジウム
- Place of Presentation
  武田薬品研修所
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] プリオン蛋白質が形成するアミロイド線維の構造とダイナミクス.「プリオン病及び遅発性ウイルス感染症に関する調査研究班プリオン班」「プリオン病のサーベイランスと感染予防に関する調査研究班」2014
- Author(s)
  桑田一夫
- Organizer
  平成25年度合同研究報告会
- Place of Presentation
  アルカディア市ヶ谷
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] X線自由電子レーザーによるアミロイド線維の一分子構造解析を目指して2014
- Author(s)
  山口圭一, 桑田一夫
- Organizer
  第三回岐阜構造生物学・医学・論理的創薬研究会シンポジウム
- Place of Presentation
  岐阜大学医学部
- Year and Date
  2014-03-18
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] X線自由電子レーザーによるアミロイド線維の一分子解析を目指して2014
- Author(s)
  山口圭一, 桑田一夫
- Organizer
  第3回岐阜構造生物学・医学・論理的創薬研究会シンポジウム
- Place of Presentation
  岐阜大学医学部
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] プリオン蛋白質が形成するアミロイド繊維の構造とダイナミックス2014
- Author(s)
  桑田一夫
- Organizer
  「プリオン病及び遅発性ウイルス感染症に関する調査研究班プリオン班」「プリオン病サーべーランスと感染症予防に関する調査研究班」平成25年度合同研究報告会
- Place of Presentation
  アルカディア市ヶ谷
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] メディカルシャペロンによるプリオン病の治療2014
- Author(s)
  桑田一夫
- Organizer
  プリオンに関する講演会
- Place of Presentation
  臨床研究情報センター
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Logical design of small molecules for the differentiation of induced pluripotent stem (iPS) cells2014
- Author(s)
  ワリード・オスマン, 桑田一夫
- Organizer
  第7回武田科学振興財団薬科学シンポジウム
- Place of Presentation
  武田製薬研修所
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] 新規プリオンアプタマーの探索とその構造研究2014
- Author(s)
  Tsukasa Mashima, Fumiko Nishikawa, Yuji O. Kamatari, Takashi Nagata, Satoshi Nishikawa, Kazuo Kuwata, Masato Katahira
- Organizer
  第52回日本生物物理学会年会
- Place of Presentation
  札幌
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Sup35天然変性領域のアミロイド構造多形形成機構の解明2014
- Author(s)
  大橋祐美子, 山口芳樹, 鎌足雄司, 花島慎弥, 桑田一夫, 田中元雅
- Organizer
  第53回NMR討論会
- Place of Presentation
  大阪
- Year and Date
  2014-11-06
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] プリオンの制御方法を学ぶ2014
- Author(s)
  鎌足雄司, 桑田一夫
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] リオン蛋白質が形成するアミロイド線維の構造とダイナミクス2014
- Author(s)
  桑田一夫
- Organizer
  「プリオン病及び遅発性ウイルス感染症に関する調査研究班プリオン班」「プリオン病のサーベイランスと感染予防に関する調査研究班」平成25年度合同研究報告会
- Place of Presentation
  アルカディア市ヶ谷
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] メディカルシャペロンによるプリオン病の治療2014
- Author(s)
  桑田一夫
- Organizer
  プリオンに関する講演会
- Place of Presentation
  臨床研究情報センター
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Logical design of small molecules for the differentiation of induced pluripotent stem (iPS) cells2014
- Author(s)
  ワリード・オスマン、桑田一夫
- Organizer
  第7回武田科学振興財団薬科学シンポジウム
- Place of Presentation
  武田薬品研修所
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] X線自由電子レーザーによるアミロイド線維の一分子構造解析を目指して2014
- Author(s)
  山口圭一、桑田一夫
- Organizer
  第三回岐阜構造生物学・医学・論理的創薬研究会シンポジウム
- Place of Presentation
  岐阜大学医学部
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] プリオン蛋白質のモンテグロビュール状態の発見とオリゴマー形成との関連2014
- Author(s)
  本田諒、山口圭一、桑田一夫
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜/横浜産貿ホール
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] キネティックＮＭＲによるタンパク質の‘かたち’の進化の観測2014
- Author(s)
  桑田一夫、山口圭一
- Organizer
  第53回ＮＭＲ討論会
- Place of Presentation
  大阪大学コンベンションセンター
- Year and Date
  2014-11-04
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] Sup35天然変性領域のアミロイド構造多形形成機構の解明2014
- Author(s)
  鎌足雄司、桑田一夫
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜/横浜産貿ホール
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] CXDIによるアミロイド線維の一分子構造解析2014
- Author(s)
  桑田一夫、山口圭一
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜/横浜産貿ホール
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] プリオン病に対するメディカルシャペロンの医師主導治験に向けて2014
- Author(s)
  桑田一夫
- Organizer
  講演会
- Place of Presentation
  国立精神・神経医療研究センター
- Year and Date
  2014-09-18
- Invited
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] 論理的創薬からGMP製造へ2014
- Author(s)
  桑田一夫
- Organizer
  日本薬学会東海支部　特別講演会
- Place of Presentation
  岐阜薬科大学
- Year and Date
  2014-04-16
- Invited
- Data Source
  KAKENHI-PROJECT-26291011
[Presentation] Application アミロイド22013
- Author(s)
  桑田一夫
- Organizer
  X-FEL第2回会合
- Place of Presentation
  独立行政法人理化学研究所池之端研究棟セミナー室
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Nearly reversible conformational change of H2 amyloid fibrils as revealed by pH-jump experiments2013
- Author(s)
  山口圭一, 鎌足雄司, 福岡万佑子, 宮地礼司 , 桑田一夫
- Organizer
  Asian Pacific Prion Symposium 2013
- Place of Presentation
  ハウステンボス
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Medical chaperone- a novel strategy for the logical drug design for prion diseases2013
- Author(s)
  桑田一夫
- Organizer
  Asian Pacific Prion Symposium 2013
- Place of Presentation
  ハウステンボス
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] プリオン病新規治療薬P092の開発について2013
- Author(s)
  桑田一夫
- Organizer
  プリオン病研修会
- Place of Presentation
  ノーベルファーマ株式会社
- Year and Date
  2013-02-27
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 論理的創薬から治験薬GMPへ2013
- Author(s)
  桑田一夫
- Organizer
  岐阜構造生物学・医学・論理的創薬研究会&岐阜超高磁場NMR利用研究会
- Place of Presentation
  岐阜大学医学部
- Year and Date
  2013-03-21
- Invited
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Logical design of a medical chaperone for prion diseases2013
- Author(s)
  桑田一夫
- Organizer
  韓国蛋白質学会
- Place of Presentation
  大田広域市, 韓国
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Structure-based drug design of small molecules for the differentiation of induced pluripotent stem (iPS) cells2013
- Author(s)
  ワリード・オスマン, 桑田一夫
- Organizer
  Small RNAs to Stem Cells & Epigenetic Reprogramming Asia-2013 Meeting
- Place of Presentation
  東京大学本郷キャンパス
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] ダブルpHジャンプによるH2アミロイド線維のほぼ可逆的な構造変化2013
- Author(s)
  山口圭一, 鎌足雄司, 福岡万佑子, 宮地礼司, 桑田一夫
- Organizer
  第13回蛋白質科学会年会
- Place of Presentation
  とりぎん文化会館
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] MEDICAL CHAPERONE - A NOVEL STRATEGY FOR THE LOGICAL DRUG DESIGN2013
- Author(s)
  桑田一夫
- Organizer
  DRUG DISCOVERY & THERAPY WORLD CONGRESS 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Mechanisms of amyloid conformational polymorphism in yeast prion Sup352013
- Author(s)
  大橋祐美子, 山口芳樹, 鎌足雄司, 花島慎弥, 桑田一夫, 田中元
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Almost Reversible Conformational Change of H2 Amyloid Fibrils as Revealed by Double pH-jump2013
- Author(s)
  山口圭一, 鎌足雄司, 福岡万佑子, 宮地礼司, 桑田一夫
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Mechanism of recognition of RNA aptamer as to prion protein and its anti-prion activity2013
- Author(s)
  真嶋司, 西川富美子, 鎌足雄司, 藤原弘道, 遠藤美紗, 永田崇, 小瀧努, 西川諭, 桑田一夫, 片平正人
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Medical chaperone - a nobel strategy for the logical drug design2013
- Author(s)
  K. Kuwata
- Organizer
  Asian Pacific Prion Symposium 2013 in Nagasaki
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Structure-based drug design of small molecules for the differentiation of induced pluripotent stem (iPS) cells2013
- Author(s)
  ワリード・オスマン, 桑田一夫
- Organizer
  Small RNAs to Stem Cells & Epigenetic Reprogramming Asia-2013 Meeting
- Place of Presentation
  東京大学本郷キャンパス
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Appication アミロイド22013
- Author(s)
  桑田一夫
- Organizer
  X-FEL第2回会合
- Place of Presentation
  理化学研究所池之端研究棟
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Logical design of a medical chaperone for prion disease2013
- Author(s)
  K. Kuwata
- Organizer
  韓国蛋白質学会
- Place of Presentation
  大田広域市, 韓国
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Medical chaperone - a nobel strategy for the logical drug design2013
- Author(s)
  K. Kuwata
- Organizer
  Drug Discovery & Therapy World Congress 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Aptamer that exerts anti-prion activity and intelligent ribozyme whose activity switches in response to K+2013
- Author(s)
  M. Katahira, T. Mashima, Y. Yamaoki, T. Nagata, F. Nishikawa, S. Nishikawa, Y. Kamatari, K. Kuwata
- Organizer
  第51回日本生物物理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Structural basis of anti-prion aptamer and its activity2013
- Author(s)
  T. Mashima, F. Nishikawa, Y. O. Kamatari, M. Saimura, T. Nagata, S. Nishikawa, K. Kuwata, M. Katahira
- Organizer
  第51回日本生物物理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Nearly reversible conformational change of H2 amyloid fibrils as revealed by pH-jump experiments2013
- Author(s)
  K. Yamaguchi, Y. O. Kamatari, M. Fukuoka, R. Miyaji, K. Kuwata
- Organizer
  Asian Pacific Prion Symposium 2013 in Nagasaki
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] pHジャンプによるH2アミロイド線維の可逆的な構造変化2013
- Author(s)
  山口圭一, 鎌足雄司, 福岡万佑子, 宮地礼司, 桑田一夫
- Organizer
  平成24年度生物物理学会中部支部講演会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice2013
- Author(s)
  T. Nakagaki, K. Satoh, D. Ishibashi, T. Fuse, K. Sano, Y. O. Kamatari, K. Kuwata, K. Shigematsu, Y. Iwamaru, T. Takenouchi, H. Kitani, N. Nishida, R. Atarashi
- Organizer
  Asian Pacific Prion Symposium 2013 in Nagasaki
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Structural basis for conformational plasticity of yeast prion amyloid2013
- Author(s)
  M. Tanaka, Y. Ohhashi, Y. Yamaguchi, Y. Kamatari, S. Hanashima, K. Kuwata
- Organizer
  Asian Pacific Prion Symposium 2013 in Nagasaki
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] MEDICAL CHAPERONE - A NOVEL STRATEGY FOR THE LOGICAL DRUG DESIGN.2013
- Author(s)
  桑田一夫
- Organizer
  DRUG DISCOVERY & THERAPY WORLD CONGRESS 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Logical design of a medical chaperone for prion diseases.2013
- Author(s)
  桑田一夫
- Organizer
  韓国蛋白質学会
- Place of Presentation
  大田広域市，韓国
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Nearly reversible conformational change of H2 amyloid fibrils as revealed by pH-jump experiments.2013
- Author(s)
  山口圭一、鎌足雄司、福岡万佑子、宮地礼司、桑田一夫
- Organizer
  Asian Pacific Prion Symposium 2013
- Place of Presentation
  ハウステンボス
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Application　アミロイド22013
- Author(s)
  桑田一夫
- Organizer
  X-FEL第2回会合
- Place of Presentation
  独立行政法人理化学研究所　池之端研究棟セミナー室
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] メディカルシャペロンと抗プリオン物質の分類.プリオン病及び遅発性ウイルス感染症に関する調査研究班」2013
- Author(s)
  桑田一夫
- Organizer
  「プリオン病のサーベイランスと感染予防に関する調査研究班」合同研究報告会
- Place of Presentation
  アルカディア市ヶ谷
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Structure-based drug design of small molecules for the differentiation of induced pluripotent stem (iPS) cells2013
- Author(s)
  ワリード・オスマン、桑田一夫
- Organizer
  Small RNAs to Stem Cells & Epigenetic Reprogramming Asia-2013 Meeting
- Place of Presentation
  東京大学　本郷キャンパス
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Medical chaperone- a novel strategy for the logical drug design for prion diseases.2013
- Author(s)
  桑田一夫
- Organizer
  Asian Pacific Prion Symposium 2013
- Place of Presentation
  ハウステンボス
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] メディカルシャペロンと抗プリオン物質の分類2013
- Author(s)
  桑田一夫
- Organizer
  プリオン病及び遅発性ウイルス感染症に関する調査研究班」、「プリオン病のサーベイランスと感染予防に関する調査研究班」合同研究報告会
- Place of Presentation
  アルカディア市ヶ谷
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 論理的創薬から治験薬GMPへ2013
- Author(s)
  桑田一夫
- Organizer
  岐阜構造生物学・医学・論理的創薬研究会 & 岐阜超高磁場NMR利用研究会
- Place of Presentation
  岐阜大学医学部
- Invited
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] プリオン病新規治療薬P092の開発について2013
- Author(s)
  桑田一夫
- Organizer
  プリオン病研修会
- Place of Presentation
  ノーベルファーマ株式会社
- Invited
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] ダブルpHジャンプによるH2アミロイド線維のほぼ可逆的な構造変化2013
- Author(s)
  山口圭一、鎌足雄司、福岡万佑子、宮地礼司、桑田一夫
- Organizer
  第13回蛋白質科学会年会
- Place of Presentation
  とりぎん文化会館
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 抗プリオン化合物のプリオンタンパク質への結合特性による分類2012
- Author(s)
  Y. O. Kamatari, Y. Hayano, K. Yamaguchi, J. Hosokawa-Muto, K. Kuwata
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] RNA アプタマーによるプリオンタンパク質の認識2012
- Author(s)
  真嶋司, 西川富美子, 鎌足雄司, 藤原弘道, 西川諭, 桑田一夫, 片平正人
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] ITC および SPR 法から得られた蛋白質-リガンド結合の熱力学的パラメータの比較2012
- Author(s)
  鎌足雄司, 石川岳志, 桑田一夫
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Characterization of anti-prion compounds according to the binding properties to the prion protein2012
- Author(s)
  Y. O. Kamatari, Y. Hayano, K. Yamaguchi, J. Hosokawa-Muto, K. Kuwata
- Organizer
  The 26th Annual Symposum of the Protein Society
- Place of Presentation
  San Diego (USA)
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Almost Reversible Conformational Change of Amyloid Fibrils as Revealed by pH-jump Experiments2012
- Author(s)
  山口圭一, 鎌足雄司, 宮地礼司, 桑田一夫
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] ダブル pH ジャンプによるアミロイド線維のほぼ可逆的な構造変化の解析2012
- Author(s)
  K. Yamaguchi, Y. O. Kamatari, M. Fukuoka, R. Miyaji, K. Kuwata
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] 論理的創薬法の確立と抗プリオン化合物の創製シーズ創製のための戦略的組織-人獣感染防御研究センター-2012
- Author(s)
  桑田一夫
- Organizer
  臨床研究情報センター講演
- Place of Presentation
  臨床研究情報センター
- Year and Date
  2012-04-11
- Invited
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 論理的創薬に基づく疾患治療法の開発2012
- Author(s)
  桑田一夫
- Organizer
  難治性疾患統合創薬PJ第11回セミナー
- Place of Presentation
  立命館大学びわこ・くさつキャンパス
- Year and Date
  2012-03-19
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Mechanism of Medicinal Chaperone to Block the Prion' s Pathogenic Conversion Process2012
- Author(s)
  桑田一夫
- Organizer
  3rd Nagasaki Prion Symposium
- Place of Presentation
  長崎大学良順会館
- Year and Date
  2012-01-29
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 自己複製する蛋白質'プリオン'の制御2012
- Author(s)
  桑田一夫
- Organizer
  日本胎盤臨床研究会
- Place of Presentation
  東京ステーションコンファレンス
- Year and Date
  2012-05-20
- Invited
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 論理的創薬に基づく疾患治療法の開発2012
- Author(s)
  桑田一夫
- Organizer
  第1回岐阜構造生物学・医学・論理的創薬研究会シンポジウム「構造生物学・医学・論理的創薬の拠点構築を目指して」
- Place of Presentation
  岐阜大学医学部
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 論理的創薬に基づく疾患治療法の開発2012
- Author(s)
  桑田一夫
- Organizer
  第1回岐阜構造生物学・医学・論理的創薬研究会シンポジウム「構造生物学・医学・論理的創薬の拠点構築を目指して」
- Place of Presentation
  岐阜大学医学部
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Relaxation Matrix and Prion2012
- Author(s)
  桑田一夫
- Organizer
  蛋白研セミナー「International Workshop on Pharmaceutical NMR-Nucleic Acids and Prion Protein-」
- Place of Presentation
  大阪大学蛋白質研究所
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Relaxation Matrix and Prion2012
- Author(s)
  桑田一夫
- Organizer
  蛋白研セミナー「 International Workshop on Pharmaceutical NMR-Nucleic Acids and Prion Protein-」
- Place of Presentation
  大阪大学蛋白質研究所
- Year and Date
  2012-10-30
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Ｘ線回折・NMR融合アミロイド線維イメージング2012
- Author(s)
  桑田一夫
- Organizer
  X-FEL第1回会合
- Place of Presentation
  理化学研究所　播磨研究所　放射光科学総合研究センター
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] HOME　CARE OF CHILDREN WITH FOP (FIBRODYSPLASIA OSSIFICANS PROGRESSIVA)2012
- Author(s)
  Hiromi Kuwata
- Organizer
  The 4th Congress of the European Academy of Paediatric Societies (EAPS)
- Place of Presentation
  Istanbul,Turley
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Mechanism of Medicinal Chaperone to Block the Prion's Pathogenic Conversion Process2012
- Author(s)
  桑田一夫
- Organizer
  3rd Nagasaki Prion Symposium
- Place of Presentation
  長崎大学良順会館
- Year and Date
  2012-01-29
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Basic study on the anti-influenza effects of Brazilian green propolis extracts2012
- Author(s)
  Tomoaki Takemura, Tomohiko Urushisaki, Yoko Araki, Kenji Ichihara, Kazuo Kuwata
- Organizer
  APIMONDIA APIMEDICA-APIQUALITY INTERNATIONAL FORUM
- Place of Presentation
  Zhenjiang, China
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 論理的創薬法の確立と抗プリオン化合物の創製　シーズ創製のための戦略的組織-人獣感染防御研究センター-2012
- Author(s)
  桑田一夫
- Organizer
  臨床研究情報センター講演
- Place of Presentation
  臨床研究情報センター
- Invited
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] HOME CARE OF CHILDREN WITH FOP (FIBRODYSPLASIA OSSIFICANS PROGRESSIVA)2012
- Author(s)
  Hiromi Kuwata
- Organizer
  The 4th Congress of the European Academy of Paediatric Societies (EAPS)
- Place of Presentation
  Istanbul, Turley
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] X線回折・NMR融合アミロイド線維イメージング2012
- Author(s)
  桑田一夫
- Organizer
  X-FEL第1回会合
- Place of Presentation
  理化学研究所播磨研究所放射光科学総合研究センター
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 自己複製する蛋白質‘プリオン’の制御2012
- Author(s)
  桑田一夫
- Organizer
  日本胎盤臨床研究会
- Place of Presentation
  東京ステーションコンファレンス
- Invited
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 特殊及び一般形態形成理論-非可換外科学入門-2012
- Author(s)
  桑田一夫
- Organizer
  慶應義塾大学講演
- Place of Presentation
  慶應義塾大学
- Invited
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] プリオン蛋白質のコンフォメーションスイッチと核依存性複製機構2012
- Author(s)
  桑田一夫
- Organizer
  東京医科歯科大学特別講義
- Place of Presentation
  東京医科歯科大学
- Year and Date
  2012-06-19
- Invited
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] プリオン蛋白質のコンフォメーションスイッチと核依存性複製機構2012
- Author(s)
  桑田一夫
- Organizer
  東京医科歯科大学特別講義
- Place of Presentation
  東京医科歯科大学
- Invited
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 特殊及び一般形態形成理論-非可換外科学入門-2012
- Author(s)
  桑田一夫
- Organizer
  慶應義塾大学講演
- Place of Presentation
  慶應義塾大学
- Year and Date
  2012-05-26
- Invited
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 論理的創薬に基づく疾患治療法の開発2012
- Author(s)
  桑田一夫
- Organizer
  難治性疾患統合創薬PJ第11回セミナー
- Place of Presentation
  立命館大学びわこ・くさつキャンパス
- Year and Date
  2012-03-19
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] プリオン蛋白質のコンフォーメイション・スイッチ2012
- Author(s)
  桑田一夫
- Organizer
  新学術領域研究「天然変性タンパク質の分子認識機構と機能発現」第2回公開シンポジウム
- Place of Presentation
  千里ライフサイエンスセンター
- Data Source
  KAKENHI-PUBLICLY-22113509
[Presentation] Mechanism of Medicinal Chaperone to Block the Prion's Pathogenic Conversion Process2012
- Author(s)
  桑田一夫
- Organizer
  3rd Nagasaki Prion Symposium
- Place of Presentation
  長崎大学良順会館
- Year and Date
  2012-01-29
- Data Source
  KAKENHI-PUBLICLY-22113509
[Presentation] 論理的創薬に基づく疾患治療法の開発2012
- Author(s)
  桑田一夫
- Organizer
  第1回岐阜構造生物学・医学・論理的創薬研究会シンポジウム「構造生物学・医学・論理的創薬の拠点構築を目指して」
- Place of Presentation
  岐阜大学医学部
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PUBLICLY-22113509
[Presentation] 論理的創薬に基づく疾患治療法の開発2012
- Author(s)
  桑田一夫
- Organizer
  難治性疾患統合創薬PJ第11回セミナー
- Place of Presentation
  立命館大学びわこ・くさつキャンパス
- Year and Date
  2012-03-19
- Data Source
  KAKENHI-PUBLICLY-22113509
[Presentation] プリオンは, 何故, 自己複製するか?2011
- Author(s)
  桑田一夫
- Organizer
  大学院連合創薬医療情報研究科公開講座「先端を行く連合創薬医療情報研究科」
- Place of Presentation
  岐阜薬科大学
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] プリオン蛋白質のコンホメーションスイッチ2011
- Author(s)
  桑田一夫
- Organizer
  第4回タンパク質の異常凝集とその防御・修復機構に関する研究会
- Place of Presentation
  京都大学原子炉実験所
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 立体構造進化と論理的創薬を担う岐阜大NMR拠点2011
- Author(s)
  桑田一夫
- Organizer
  大阪大学蛋白質研究所セミナー「先端的NMR拠点から生まれる新たな潮流 : 最新成果, 役割, 利用」
- Place of Presentation
  大阪大学蛋白質研究所
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Regulating the Prion Conformation by Logical Drug Design2011
- Author(s)
  桑田一夫
- Organizer
  Asian Pacific Prion Symposium 2011
- Place of Presentation
  ホテルマロウド軽井沢
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 量子ロボット医薬品の設計2011
- Author(s)
  桑田一夫
- Organizer
  味の素株式会社招待講演
- Place of Presentation
  味の素株式会社イノベーション研究所
- Year and Date
  2011-12-03
- Invited
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Prion Dynamics and Logical Drug Design2011
- Author(s)
  桑田一夫
- Organizer
  Israel-Japan Joint Symposium on Biophysics "Protein Dynamics : From single molecules to whole cell"
- Place of Presentation
  兵庫県立大学
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 量子ロボット医薬品の設計2011
- Author(s)
  桑田一夫
- Organizer
  味の素株式会社招待講演
- Place of Presentation
  味の素株式会社イノベーション研究所
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] プリオンは、何故、自己複製するか?2011
- Author(s)
  桑田一夫
- Organizer
  大学院連合創薬医療情報研究科公開講座「先端を行く連合創薬医療情報研究科」
- Place of Presentation
  岐阜薬科大学
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Regulating the Prion Conformation by Logical Drug Design2011
- Author(s)
  桑田一夫
- Organizer
  Asian Pacific Prion Symposium 2011
- Place of Presentation
  ホテルマロウド軽井沢
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] 立体構造進化と論理的創薬を担う岐阜大NMR拠点2011
- Author(s)
  桑田一夫
- Organizer
  大阪大学蛋白質研究所セミナー「先端的NMR拠点から生まれる新たな潮流:最新成果,役割,利用」
- Place of Presentation
  大阪大学蛋白質研究所
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] プリオン蛋白質のコンホメーションスイッチ2011
- Author(s)
  桑田一夫
- Organizer
  第4回タンパク質の異常凝集とその防御・修復機構に関する研究会
- Place of Presentation
  京都大学原子炉実験所
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Prion Dynamics and Logical Drug Design2011
- Author(s)
  桑田一夫
- Organizer
  Israel-Japan Joint Symposium on Biophysics "Protein Dynamics : From single molecules to whole cell"
- Place of Presentation
  兵庫県立大学
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-23370068
[Presentation] Regulating the Prion Conformation by Logical Drug Design2011
- Author(s)
  桑田一夫
- Organizer
  Asian Pacific Prion Symposium 2011
- Place of Presentation
  ホテルマロウド軽井沢
- Data Source
  KAKENHI-PUBLICLY-22113509
[Presentation] 立体構造進化と論理的創薬を担う岐阜大NMR拠点2011
- Author(s)
  桑田一夫
- Organizer
  大阪大学蛋白質研究所セミナー「先端的NMR拠点から生まれる新たな潮流:最新成果,役割,利用」
- Place of Presentation
  大阪大学蛋白質研究所
- Data Source
  KAKENHI-PUBLICLY-22113509
[Presentation] プリオン蛋白質のコンホメーションスイッチ2011
- Author(s)
  桑田一夫
- Organizer
  第4回タンパク質の異常凝集とその防御・修復機構に関する研究会
- Place of Presentation
  京都大学原子炉実験所
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PUBLICLY-22113509
[Presentation] プリオン分子内におけるポリAとポリTの稀な出会い2011
- Author(s)
  桑田一夫
- Organizer
  新学術領域「天然変性蛋白質」第2回領域会議
- Place of Presentation
  青島パームビーチホテル
- Data Source
  KAKENHI-PUBLICLY-22113509
[Presentation] Prion Dynamics and Logical Drug Design2011
- Author(s)
  桑田一夫
- Organizer
  Israel-Japan Joint Symposium on Biophysics "Protein Dynamics : From single molecules to whole cell"
- Place of Presentation
  兵庫県立大学
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PUBLICLY-22113509
[Presentation] 量子ロボット医薬品の設計2011
- Author(s)
  桑田一夫
- Organizer
  味の素株式会社招待講演
- Place of Presentation
  味の素株式会社イノベーション研究所
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PUBLICLY-22113509
[Presentation] プリオンは、何故、自己複製するか?2011
- Author(s)
  桑田一夫
- Organizer
  大学院連合創薬医療情報研究科公開講座「先端を行く連合創薬医療情報研究科」
- Place of Presentation
  岐阜薬科大学
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PUBLICLY-22113509
[Presentation] 電子顕微鏡によるプリオンの構造解析に向けて2010
- Author(s)
  桑田一夫
- Organizer
  平成21年度日本顕微鏡学会関西支部特別企画講演会
- Place of Presentation
  岡崎コンファレンスセンター
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] 構造生物学に基づく疾患治療薬の開発-銅結合タンパク質への応用-2010
- Author(s)
  桑田一夫
- Organizer
  第15回東海メタロチオネイン研究会
- Place of Presentation
  岐阜大学医学部付属病院
- Year and Date
  2010-03-13
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] 構造生物学的アプローチによる抗プリオン化合物の開発2010
- Author(s)
  桑田一夫
- Organizer
  平成21年度富山大学大学院生命融合科学教育部シンポジウム「富山発医療・創薬イノベーションに向けて」
- Place of Presentation
  高志会館
- Year and Date
  2010-03-08
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] 数論、ダイナミクス、プリオン2010
- Author(s)
  桑田一夫
- Organizer
  生物物理第48回年会
- Place of Presentation
  東北大学・川内北キャンパス
- Data Source
  KAKENHI-PUBLICLY-22113509
[Presentation] インフルエンザ治療薬開発2009
- Author(s)
  桑田一夫
- Organizer
  第40回中部化学関係学協会支部連合秋季大会
- Place of Presentation
  岐阜大学
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] HIVプロテアーゼ阻害能を示す低分子化合物2009
- Author(s)
  金本大成、中村寛則、寺久保繁美、浅井大輔、桑田一夫、中島秀喜
- Organizer
  第66回神奈川県感染症医学会学術集会
- Place of Presentation
  日本大通りビル2F松村ガーデンホール
- Year and Date
  2009-09-12
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] 抗プリオン化合物GN8の類縁体合成および活性評価2009
- Author(s)
  木村力、武藤淳二、鎌足雄司、桑田一夫
- Organizer
  第40回中部化学関係学協会支部連合秋季大会
- Place of Presentation
  岐阜大学
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] 抗プリオン化合物の作用機序:ケミカルシャペロンによるプリオンタンパクの構造制御2009
- Author(s)
  山本典史、桑田一夫
- Organizer
  第3回分子科学討論会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] ケミカルシャペロンとして働く抗プリオン化合物GN82009
- Author(s)
  山本典史、桑田一夫
- Organizer
  日本生物物理学会第47回年会
- Place of Presentation
  アスティとくしま
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] Nucleoproteinをターゲットにした新規抗インフルエンザ薬の開発2009
- Author(s)
  荻原恭二、上田敦史、中村寛則、本田香織、近藤恭光、長田裕之、桑田一夫
- Organizer
  第147回日本獣医学会学術集会
- Place of Presentation
  栃木県総合文化センター
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] 低分子化合物による難治感染症克服-ケミカルバイオロジーから創薬-異常プリオンを抑える物質の発見とそのメカニズムの解明2009
- Author(s)
  桑田一夫(座長)
- Organizer
  第147回日本獣医学会学術集会
- Place of Presentation
  栃木県総合文化センター
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] プリオン病-感染メカニズムとダイナミクスに基づく創薬2009
- Author(s)
  桑田一夫
- Organizer
  日本生物物理学会第47回年会
- Place of Presentation
  アスティとくしま
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] 論理的創薬法による抗プリオン物質の設計と開発2009
- Author(s)
  桑田一夫
- Organizer
  東海3大学新技術説明会
- Place of Presentation
  科学技術振興機構JSTホール(東京)
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] 低分子化合物によるタンパク質のコンフォーメイション2009
- Author(s)
  桑田一夫
- Organizer
  長崎大学感染免疫学講座感染分子解析学第2回長崎プリオン研究会
- Place of Presentation
  長崎大学医学部良順会館ボードウィンホール
- Year and Date
  2009-04-17
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] シーディングによる2種類のプリオンアミロイド線維の伝播2009
- Author(s)
  山口圭一、松本友治、武藤淳二、桑田一夫
- Organizer
  日本生物物理学会第47回年会
- Place of Presentation
  アスティとくしま
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] プリオン立体構造変換の物理2009
- Author(s)
  桑田一夫
- Organizer
  第64回日本物理学会年会
- Place of Presentation
  立教大学
- Year and Date
  2009-03-29
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] アンバーおよび4塩基コドンを用いたデュアルピンポイント蛍光標識プリオン蛋白質の合成2009
- Author(s)
  武藤淳二、山口圭一、鎌足雄司、桑田一夫
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  都市センターホテル
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] プリオンの立体構造を制御する低分子化合物の開発2009
- Author(s)
  桑田一夫
- Organizer
  第120回日本薬理学会
- Place of Presentation
  東京医科歯科大学
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] Identification of a variety of anti-prion compounds that acts as chemical chaperons.2009
- Author(s)
  鎌足雄司、武藤淳二、中村寛則、早野陽介、桑田一夫
- Organizer
  V III European Symposium of The Protein Society
- Place of Presentation
  Zurich Switzerland
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] Regulation of protein conformation by rationally designed drugs.2009
- Author(s)
  桑田一夫(オーガナイザー)
- Organizer
  International Symposium on Multi-Scale Dynamic of Protein Complex Formation and Function
- Place of Presentation
  The University of Tokyo
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] Regulating Conformation of Prion Protein through Ligand Binding.2009
- Author(s)
  山本典史、桑田一夫
- Organizer
  The 23^<rd> Symposium of The Protein Society
- Place of Presentation
  Boston, Massachusetts
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] New evaluation scheme for anti-prion compounds using ensemble of docking modes.2009
- Author(s)
  中村寛則、武藤淳二、鎌足雄司、桑田一夫
- Organizer
  V III European Symposium of The Protein Society
- Place of Presentation
  Zurich Switzerland
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] Rational design of anti-prion compounds targeting the PrP characteristic sites.2009
- Author(s)
  Kazuo Kuwata, Tsutomu Kimura, Yuji O.Kamatari, Junji Hosokawa-Muto, Keiichi Yamaguchi, Takeshi Ishikawa, Takakazu Ishikura, Norifumi Yamamoto, Yumiko Okuda.
- Organizer
  Prion2009
- Place of Presentation
  Thessaloniki-Chalkidiki Greece
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] Development of double-fluorescent-labeled prion protein system for FRET analysis.2009
- Author(s)
  武藤淳二、山口圭一、鎌足雄司、桑田一夫
- Organizer
  V III European Symposium of The Protein Society
- Place of Presentation
  Zurich Switzerland
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] A variety of anti-prion compounds discovered by an in silico screening based on PrPc structure : a correlation between anti-prion activity and binding affinity2008
- Author(s)
  桑田一夫
- Organizer
  Prion 2008
- Place of Presentation
  Auditorium Hotel Madrid
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] Dynamics Based Design of Anti-Prion Compounds Uncovered the Hot Spots for Prion's Pathogenic Conversion Reaction2008
- Author(s)
  桑田一夫
- Organizer
  EHRLICH II 2^<nd> WORLD CONFERENCE ON MAGIC BULLETS Celebrating the 100th Anniversary of the Nobel Prize Awarded to Paul Ehrlich
- Place of Presentation
  Germany Nuernberg
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] Thermodynamics of quantum cryptography for representation of prion2008
- Author(s)
  桑田一夫
- Organizer
  2008年プリオン研究会Prion Symposium 2008
- Place of Presentation
  サホロリゾート
- Data Source
  KAKENHI-PROJECT-20059016
[Presentation] プリオンのダイナミクスに基づく抗プリオン薬のデザイン2007
- Author(s)
  桑田一夫, 鎌足雄司, 松本友治, 中村寛則, 早野陽介
- Organizer
  The 45nd Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  Pacifico Yokohama
- Data Source
  KAKENHI-PROJECT-18031015
[Presentation] A hot spot in prion protein for pathogenic conversion:Proteins:From Birth to Death2007
- Author(s)
  Kazuo Kuwata
- Organizer
  21st Annual Symposium of The Protein Society
- Place of Presentation
  Boston,Massachusetts,Boston Marriott Copley Place
- Data Source
  KAKENHI-PROJECT-18031015
[Presentation] カルボニル還元酵素（CBR1）阻害活性を有する8-Hydroxy-2-imino-2H-chromene-3-carboxamide誘導体の創製
- Author(s)
  小栗　弘成、遠藤　智史、宮城　菜未希、胡　大イ、荒井　裕貴、松永　俊之、五十里　彰、桑田　一夫、原　明、合田　浩明、豊岡　尚樹
- Organizer
  第32回メディシナルシンポジウム
- Place of Presentation
  神戸国際会議場
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-26291011

1. KAMATARI Yuji (70342772)

# of Collaborated Projects : 4results

# of Collaborated Products : 39results
2. ERA Seiichi (30152002)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
3. AKASAKA Kazuyuki (50025368)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
4. AOKI Mituhiro (30283302)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
5. NISHIDA Noriyuki (40333520)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
6. NAKAMURA Koji (70242724)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. GOTO Yuji (40153770)

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8. MIZUTA Keisuke (10190638)

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# of Collaborated Products : 0results
9. KUWATA Hiromi (70324316)

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# of Collaborated Products : 0results
10. SAKAMOTO Yutaka (20310039)

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11. SHIRASAKA Maki (40378443)

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12. KOSHIDA Shigeki (70372547)

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# of Collaborated Products : 0results
13. SOGA Hiroyoshi (40614045)

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14. ODA Masayuki (20318231)

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15. ISHIKAWA Takeshi (80505909)

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16. HOSHINO Masaru (70304053)

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17. KAWATA Yasushi (40177697)

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18. ITO Yatsuji (60135192)

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19. TACHIBANA Hideki (70126118)

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20. HAYASHI Tomoya (70293561)

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21. KINOSADA Yasutomi (50161526)

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22. ASANO Takahiko (50313903)

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23. KATAMINE Shigeru (40161062)

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24. ITO Takasi (90306275)

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25. ISHIGURO Naotaka (00109521)

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26. YANAI Takuma (10242744)

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27. HORIUCHI Motohiro (30219216)

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28. SOGAMI Masaru (00034900)

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29. UYEDA Motoji (90021401)

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30. 山口圭一 (90432187)

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31. 武藤淳二 (80432186)

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32. 片岡幹雄 (30150254)

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33. 久世文也 (70313898)

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34. 丸尾幸嗣 (40124276)

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35. BATT Carl A.

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36. CARL A. Batt

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37. MATUBAYASI Nobuyuki

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38. KITAO Akio

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39. YAMAMOTO Norifumi

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40. NAGAOKA Masataka

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41. TAKADA Shoji

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42. ENDO Satoshi

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43. Matsunaga Toshiyuki

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44. SATOH Katsuya

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45. ATARASHI Ryuichiro

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46. ISHIBASHI Daisuke

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47. SANO KAZUNORI

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48. WADA Yasuhiro

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49. CUI Yilong

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50. SUZUKI Masaaki

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# of Collaborated Products : 2results
51. DOI Hisashi

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52. Kataoka Yosky

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53. NAGATA Takashi

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# of Collaborated Products : 2results
54. KATAHIRA Masato

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# of Collaborated Products : 2results
55. MASHIMA Tsukasa

# of Collaborated Projects : 0results

# of Collaborated Products : 2results

KUWATA Kazuo 桑田 一夫

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マイクロ流路超高速パルスラベルNMR装置の開発及びプリオン自己複製過程の解明Principal InvestigatorOngoing

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Experimental analysis of conformational evolution process of a prion by developing the kinetic NMRPrincipal Investigator

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プリオン天然変性部位の異常立体構造変換における役割Principal Investigator

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細胞内プリオンタンパク質の立体構造、ダイナミクス、及び立体構造変換反応の解明Principal Investigator

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原子分解能かつナノ秒時間分解能でのプリオン・フォールディング反応の観測Principal Investigator

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プリオン部分ペプチドが作るオリゴマーの立体構造決定Principal Investigator

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核磁気共鳴法を用いた新しい抗プリオン薬開発戦略の確立Principal Investigator

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温度ジャンプによるプリオン中間体形成反応の速度論的解析Principal Investigator

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プリオン活性型立体構造に基づくプリオン病予防・治療薬の開発Principal Investigator

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New Concept on the Phase Space of the Protein : Experiments and TheoryPrincipal Investigator

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KUWATA Kazuo 桑田一夫