Hayashi Hideyuki 林秀行

… Alternative Names

HAYASHI Hideyuki 林秀行

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Researcher Number	00183913
Other IDs
Affiliation (Current)	2025: 千里金蘭大学, 看護学部, 教授 2025: 大阪医科薬科大学, 医学部, 名誉教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪医科薬科大学, 医学部, 名誉教授 2021 – 2022: 大阪医科薬科大学, 医学部, 教授 2009 – 2020: Osaka Medical College, 医学部, 教授 2004 – 2005: 大阪医科大学, 医学部, 教授 1998 – 2003: 大阪医科大学, 医学部, 助教授 … More 1999: Osaka Medical College, Dept. of Biochemistry, Associate Professor 1994 – 1996: 大阪医科大学, 医学部, 助教授 1993: 大阪医科大学, 医学部, 講師 1990 – 1992: 大阪医科大学, 講師 Less
Review Section/Research Field	Principal Investigator Functional biochemistry / Structural biochemistry / Structural biochemistry / Bio-related chemistry / Functional biochemistry / Science and Engineering Except Principal Investigator Structural biochemistry / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 43020:Structural biochemistry-related / Physical chemistry / Science and Engineering / Neuroscience in general / Functional biochemistry
Keywords	Principal Investigator ピリドキサールリン酸 / プロトン移動 / 触媒反応機構 / pKa / 遷移相速度論 / アミノ基転移酵素 / 歪み / X線結晶解析 / 酵素反応機構 / aminotransferase … More / エネルギー障壁 / catalytic-mechanism / proton-transfer / 自由エネルギー / strain / コンフォメーション / 解離基 / pK_a / pyridoxal 5'-phosphate / アスパラギン酸アミノ基転移酵素 / 反応中間体 / 反応速度論 / 立体化学 / 芳香族アミノ酸アミノトランスフェラーゼ / シッフ塩基 / 芳香族アミノ酸デカルボキシラーゼ / ハロゲン化物イオン / 銅イオン / pH依存性 / トーパキノン / キノタンパク質 / 補欠分子族 / 反応駆動力 / エネルギー準位図 / 電子移動 / catalytic mechanism / energy barrier / amine oxidase / tunneling / driving force / proton transfer / 触媒反応 / 理論計算 / コンフォメーション変化 / 蛋白質 / アミン酸化酵素 / トンネル効果 / 駆動力 / energy-barrier / free-energy-profile / pyridoxal-phosphate / 自由エネルギー図 / composite-biocatalyst / transferase / stereochemistry / induced-fit / free-energy / スフィンゴ脂質 / コンポジット触媒 / 転移酵素 / 誘導適合 / pyridoxal phosphate / activation energy / transition state / conformation / proton / dissociation group / 酸塩基化学 / 基質結合過程 / 活性化エネルギー / 遷移状態 / プロトン / X-ray crystallography / guanidinium group / hydrogen bond / reaction intermediate / substrate analog / substrate specificity / aromatic amino acid aminotransferase / ピリドキサミンリン酸 / アスパラギン酸アミノトランスフェラーゼ / リシン / アルギニン / 芳香環 / 酵素反応速度論 / 基質認識機構 / Paracoccus denitrificans / 大腸菌 / X-線結晶解析 / グアニジノ基 / 水素結合 / 基質アナログ / 基質特異性 / 芳香族アミノ酸アミノ基転移酵素 / Ｘ線結晶解析 / 量子化学計算 / 補酵素 / 副反応 / プロトン化状態 / ピリドキサール5'-リン酸 / 生成物支援触媒 / 基質支援触媒 / 反応特異性 / エネルギー進位 / 計算化学 / タンパク質のゆらぎ / 銅アミン酸化酵素 / トレオニン合成酵素 / セリンパルミトイル転移酵素 / エネルギー準位 / 反応機構 / キノン酵素 / ピリドキサール酵素 / アスパラギン酸残基 / ヒスチジン残基 / 脱プロトン化 / 互変異構造 … More Except Principal Investigator トパキノン / レーザーホトリシス / 光反応ダイナミックス / ピリドキサールリン酸 / アミン酸化酵素 / HAG法 / 補酵素 / 酵素 / X線結晶構造解析 / 酵素反応 / 反応機構 / アミノ基転移酵素 / 量子計算 / 結晶構造 / 結晶構造解析 / 反応中間体 / 結晶 / 蛋白質 / 銅含有アミン酸化酵素 / 量子古典混合計算 / スーパーコンピュータ / molecular dynamics (MD) / 副反応経路 / 反応制御機構 / 反応制御 / スパコン / 自由エネルギー / molecular dynamics / QM/MM / 生成物支援機構 / トレオニン合成酵素 / built-in cofactor / heme / flavin / cobalamin / pyridoxal phosphate / structure activity relationship / coenzyme / composite biocatalyst / キノヘムプロテイン / ビルトイン補酵素 / ヘム / フラビン / コバラミン / ピリドキサルリン酸 / 構造活性相関 / コンポジット生体触媒 / Cerebellar Efferent Pathway / Visual Pathway / Olfactory Pathway / Adenovirus / Transgenic Mouse / Neural Network / Transsynaptic Tracer / Wheat Germ Agglutinin / 小脳遠心性神経回路 / 嗅覚系神経回路 / 視覚回路 / 嗅覚経路 / 小脳遠心性経路 / アデノウイルス / トランスジェニックマウス / 神経回路網 / 経シナプス性トレーサー / WGA / 小麦胚芽レクチン / X-ray crystallography / Structure and function relationship / Substrate specificity / Catalytic activity / Amino acid substitution / Genetic engineering / Pyridoxal / Aminotransferse / ビタミンB6 / 酵素構造 / ピリドキサ-ル / アスパラギン酸 / X線結晶解析 / 機能構造相関 / 基質特異性 / 触媒機能 / アミノ酸残基置換 / 遺伝子工学 / ピリドキサール / Ｘ線 / 中性子 / X線結晶構造回析 / 中性子結晶構造回析 / 中性子結晶構造解析 / スフィンゴシン1-リン酸 / 微生物 / 生体分子 / スフィンゴシン1-リン酸リアーゼ / セリンパルミトイル転移酵素 / スフィンゴ脂質 / タンパク質 / 酵素の触媒機構 / コンホメーション変化 / 時間分割構造変化 / 変異型酵素 / ラウエ法 Less

Visualization of protonated states of dissociative substituents by cooperation of quantum calculations and crystal structures
- Principal Investigator
  
  藤橋雅宏
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Osaka Medical and Pharmaceutical University
非凍結結晶を用いた“in crystallo”酵素反応解析
- Principal Investigator
  
  村川武志
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Osaka Medical and Pharmaceutical University
In crystallo thermodynamic analysis of the cofactor conformational change of copper amine oxidase
- Principal Investigator
  
  Murakawa Takeshi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka Medical College
Concerted proton/electron transfer mechanism in cofactor-dependent enzymePrincipal Investigator
- Principal Investigator
  
  HAYASHI Hideyuki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Osaka Medical College
X-ray and neutron crystallographic structure of copper amine oxidase
- Principal Investigator
  
  Murakawa Takeshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka Medical College
Theoretical elucidation on the full reaction mechanisms of threonine synthase
- Principal Investigator
  
  SHOJI MITSUO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical chemistry
- Research Institution
  University of Tsukuba
Reaction specificity of pyridoxal enzymesPrincipal Investigator
- Principal Investigator
  
  Hayashi Hideyuki
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka Medical College
Multidimensional energy analysis of pyridoxal-enzyme and quinoenzyme reactionsPrincipal Investigator
- Principal Investigator
  
  HAYASHI Hideyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka Medical College
Studies on the molecular mechanism of sphingolipid metabolism based on the crystal structure of the enzymes
- Principal Investigator
  
  IKUSHIRO Hiroko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka Medical College
Studies on the proton transfer processes in pyridoxal enzymesPrincipal Investigator
- Principal Investigator
  
  HAYASHI Hideyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka Medical College
Molecular Design and Evolution Engineering for Compositc Biochatalysts
- Principal Investigator
  
  TORAYA Tetsuo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  KYOTO UNIVERSITY
Designing composite biocatalysts by analysis of the proton-transfer process in pyridoxal enzymesPrincipal Investigator
- Principal Investigator
  
  HAYASHI Hideyuki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Osaka Medical College
Proton-transfer mechanism of pyridoxal enzymes studied by 3D-free energy profilePrincipal Investigator
- Principal Investigator
  
  HAYASHI Hideyoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka Medical College
The proton-transfer mechanism of the catalytic reactions of pyridoxal enzymesPrincipal Investigator
- Principal Investigator
  
  HAYASHI Hideyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka Medical College
Development and application of a novel genetic strategy for visualization of functional neural pathways
- Principal Investigator
  
  YOSHIHARA Yoshihiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  RIKEN
タンパク質内部高秩序環境場におけるピリドキサールリン酸の光反応ダイナミックス
- Principal Investigator
  
  原三郎
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Institute of Technology
タンパク質内部高秩序環境場におけるピリドキサールリン酸の光反応ダイナミックス
- Principal Investigator
  
  原三郎
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Institute of Technology
高品質結晶によるアミノ基転移酵素の反応中間体の高分解能構造解析
- Principal Investigator
  
  HIROTSU Ken
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka City University
タンパク質内部高秩序環境場におけるピリドキサールリン酸の光反応ダイナミックス
- Principal Investigator
  
  原三郎
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Institute of Technology
Substrate-Recognition Mechanism of Aromatic Amino Acid AminotransferasePrincipal Investigator
- Principal Investigator
  
  HAYASHI Hideyuki
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka Medical College
芳香族L-アミノ酸デカルボキシラーゼの構造と機能の解析Principal Investigator
- Principal Investigator
  
  林秀行
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka Medical College
Structure and Function of Aspartate Aminotransferase
- Principal Investigator
  
  MORINO Yoshimasa
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KUMAMOTO UNIVERSITY

[Book] ビタミン総合事典2011
- Author(s)
  生城浩子, 林秀行
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-21570149
[Book] ビタミン総合事典2011
- Author(s)
  林秀行, 生城浩子
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-21570149
[Book] タンパク質科学第9章触媒機能(後藤祐児・桑島邦博・谷澤克行編)2005
- Author(s)
  林秀行
- Total Pages
  579
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-16570125
[Journal Article] Molecular mechanism of a large conformational change of the quinone cofactor in the semiquinone intermediate of bacterial copper amine oxidase2022
- Author(s)
  Shoji Mitsuo、Murakawa Takeshi、Nakanishi Shota、Boero Mauro、Shigeta Yasuteru、Hayashi Hideyuki、Okajima Toshihide
- Journal Title
  
  Chemical Science
  
  Volume: 13 Issue: 36 Pages: 10923-10938
- DOI
  10.1039/d2sc01356h
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06530, KAKENHI-PROJECT-22H04916, KAKENHI-PLANNED-20H05453, KAKENHI-PUBLICLY-22H04757, KAKENHI-PUBLICLY-22H04800
[Journal Article] Microcrystal preparation for serial femtosecond X-ray crystallography of bacterial copper amine oxidase2021
- Author(s)
  Murakawa Takeshi、Suzuki Mamoru、Arima Toshi、Sugahara Michihiro、Tanaka Tomoyuki、Tanaka Rie、Iwata So、Nango Eriko、Tono Kensuke、Hayashi Hideyuki、Fukui Kenji、Yano Takato、Tanizawa Katsuyuki、Okajima Toshihide
- Journal Title
  
  Acta Crystallographica Section F Structural Biology Communications
  
  Volume: 77 Issue: 10 Pages: 356-363
- DOI
  10.1107/s2053230x21008967
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05694, KAKENHI-PLANNED-19H05781, KAKENHI-PUBLICLY-20H05448, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-20K06238, KAKENHI-PROJECT-20K06530, KAKENHI-PLANNED-19H05777
[Journal Article] Unique protonation states of aspartate and topaquinone in the active site of copper amine oxidase2020
- Author(s)
  Shoji Mitsuo、Murakawa Takeshi、Boero Mauro、Shigeta Yasuteru、Hayashi Hideyuki、Okajima Toshihide
- Journal Title
  
  RSC Advances
  
  Volume: 10 Issue: 63 Pages: 38631-38639
- DOI
  10.1039/d0ra06365g
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05694, KAKENHI-PROJECT-20K06530, KAKENHI-PUBLICLY-20H05088, KAKENHI-PUBLICLY-20H05448, KAKENHI-PLANNED-20H05453, KAKENHI-PUBLICLY-20H05497, KAKENHI-PROJECT-17K07317
[Journal Article] In crystallo thermodynamic analysis of conformational change of the topaquinone cofactor in bacterial copper amine oxidase2018
- Author(s)
  Murakawa Takeshi、Baba Seiki、Kawano Yoshiaki、Hayashi Hideyuki、Yano Takato、Kumasaka Takashi、Yamamoto Masaki、Tanizawa Katsuyuki、Okajima Toshihide
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 1 Pages: 135-140
- DOI
  10.1073/pnas.1811837116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16KT0055, KAKENHI-PROJECT-17K07317, KAKENHI-PROJECT-15K05573
[Journal Article] Molecular Mechanism of the Reaction Specificity in Threonine Synthase: Importance of the Substrate Conformations2017
- Author(s)
  Ujiie Yuzuru，Tanaka Wataru，Hanaoka Kyohei，Harada Ryuhei，Kayanuma Megumi，Shoji Mitsuo，Murakawa Takeshi，Ishida Toyokazu，Shigeta Yasuteru，Hayashi Hideyuki
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 121 Issue: 22 Pages: 5536-5543
- DOI
  10.1021/acs.jpcb.7b02932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K05573, KAKENHI-PROJECT-16H06164, KAKENHI-PROJECT-15J03797
[Journal Article] Role of the Tyr270 residue in 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti.2017
- Author(s)
  Kobayashi J., Yoshida H., Yagi T., Kamitori S., Hayashi H., Mizutani K., Takahashi N., Mikami B.
- Journal Title
  
  J. Biosci. Bioeng.
  
  Volume: 123 Issue: 2 Pages: 154-162
- DOI
  10.1016/j.jbiosc.2016.07.022
- NAID
  40021112404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04909, KAKENHI-PROJECT-15K05573
[Journal Article] Probing the Catalytic Mechanism of Copper Amine Oxidase from Arthrobacter globiformis with Halide Ions.2015
- Author(s)
  Murakawa, T., Hamaguchi, A., Nakanishi, S., Kataoka, M., Nakai, T., Kawano, Y., Yamaguchi, H., Hayashi, H., Tanizawa, K., and Okajima, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Issue: 38 Pages: 23094-23109
- DOI
  10.1074/jbc.m115.662726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K05573, KAKENHI-PROJECT-15K07391, KAKENHI-PROJECT-26440037
[Journal Article] A QM/MM Study of the l-Threonine Formation Reaction of Threonine Synthase: Implications into the Mechanism of the Reaction Specificity.2014
- Author(s)
  Shoji, M., Hanaoka, K., Ujiie, Y., Tanaka, W., Kondo, D., Umeda, H., Kamoshida, Y., Kayanuma, M., Kamiya, K., Shiraishi, K., Machida, Y., Murakawa, T., and Hayashi, H.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 136 Issue: 12 Pages: 4525-4533
- DOI
  10.1021/ja408780c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570140, KAKENHI-PROJECT-24750007
[Journal Article] A QM/MM Study of the l-Threonine Formation Reaction of Threonine Synthase: Implications into the Mechanism of the Reaction Specificity2014
- Author(s)
  M.Shoji, K.Hanaoka, Y.Ujiie, W.Tanaka, D.Kondo, H.Umeda, Y.Kamoshida, M.Kayanuma, K.Kamiya, K.Shiraishi,Y.Machida, T.Murakawa, H.Hayashi
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26410002
[Journal Article] Structural insights into the substrate specificity of bacterial copper amine oxidase obtained by using irreversible inhibitors2012
- Author(s)
  Murakawa T, Hayashi H, Taki M, Yamamoto Y, Kawano Y, Tanizawa K, Okajima T.
- Journal Title
  
  J Biochem
  
  Volume: 151 Pages: 167-178
- NAID
  10031166055
- Data Source
  KAKENHI-PROJECT-21570120
[Journal Article] Structural insights into the substrate specificity of bacterial copper amine oxidase obtained by using irreversible inhibitors2012
- Author(s)
  Hideyuki Hayashi, Takeshi Murakawa
- Journal Title
  
  J.Biochem.
  
  Volume: 151 Issue: 2 Pages: 167-178
- DOI
  10.1093/jb/mvr125
- NAID
  10031166055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570120, KAKENHI-PROJECT-23685039
[Journal Article] Mechanistic enzymology of serine palmitoyltransferase2011
- Author(s)
  Ikushiro, H., Hayashi, H.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: Vol.1814, No.11 Pages: 1474-1480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570149
[Journal Article] Analysis of mammalian histidine decarboxylase dimerization interface reveals an electrostatic hotspot important for catalytic site topology and function2011
- Author(s)
  Moya-Garcia, A. A., Rodriguez-Agudo, D., Hayashi, H., Medina, M. A., Urdiales, J. L., Sanchez-Jimenez, F.
- Journal Title
  
  J. Chem. Theory. Comput
  
  Volume: 7 Pages: 1935-1942
- Data Source
  KAKENHI-PROJECT-21570120
[Journal Article] Role of a conserved arginine residue during catalysis in serine palmitoyltransferase2011
- Author(s)
  Lowther, J., Charmier, G., Raman, M. C., Ikushiro, H., Hayashi, H., Campopiano, D. J.
- Journal Title
  
  FEBS Lett
  
  Volume: 585 Pages: 1729-1734
- Data Source
  KAKENHI-PROJECT-21570120
[Journal Article] セリンパルミトイル転移酵素の触媒反応におけるHis159の多機能的役割2011
- Author(s)
  生城浩子, 白岩有桂, 林秀行
- Journal Title
  
  ビタミン
  
  Volume: 84巻, 9号 Pages: 423-431
- NAID
  110007730458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570149
[Journal Article] 細菌セリンパルミトイル転移酵素の構造と触媒機構解析2011
- Author(s)
  生城浩子, 林秀行
- Journal Title
  
  生化学
  
  Volume: 83巻, 2号 Pages: 105-110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570149
[Journal Article] Role of a conserved arginine residue during catalysis in serine palmitoyltransferase2011
- Author(s)
  Hideyuki Hayashi
- Journal Title
  
  FEBS Lett.
  
  Volume: 585 Issue: 12 Pages: 1729-1734
- DOI
  10.1016/j.febslet.2011.04.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570120, KAKENHI-PROJECT-21570149
[Journal Article] Product-assisted catalysis as the basis of the reaction specificity of threonine synthase2011
- Author(s)
  Murakawa, T., Machida, Y., Hideyuki Hayashi
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 2774-2784
- Data Source
  KAKENHI-PROJECT-21570120
[Journal Article] Analysis of mammalian histidine decarboxylase dimerization interface reveals an electrostatic hotspot important for catalytic site topology and function2011
- Author(s)
  Hideyuki Hayashi
- Journal Title
  
  J.Chem.Theory Comput.
  
  Volume: 7 Issue: 6 Pages: 1935-1942
- DOI
  10.1021/ct100690p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570120
[Journal Article] Role of a conserved arginine residue during catalysis in serine palmitoyltransferase.2011
- Author(s)
  Lowther, J, Charmier, G., Raman, M. C., Ikushiro, H., Hayashi, H., Campopiano, D. J.
- Journal Title
  
  FEBS Lett.
  
  Volume: Vol.585, No.12 Pages: 1729-1734
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570149
[Journal Article] Multifunctional role of His159in the catalytic reaction of serine palmitoyltransferase.2009
- Author(s)
  Shiraiwa, Y., Ikushiro, H., Hayashi, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: Vol.284, No.23 Pages: 15487-15495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570149
[Journal Article] Structural insights into the enzymatic mechanism of serine palmitoyltransferase from Sphingobacterium multivorum.2009
- Author(s)
  Ikushiro, H., Islam, M. M., Okamoto, A., Hoseki, J., Murakawa, T., Fujii, S., Miyahara, I., Hayashi, H.
- Journal Title
  
  J. Biochem.
  
  Volume: Vol.146, No.4 Pages: 549-562
- NAID
  10026304060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570149
[Journal Article] Multifunctional role of His159 in the catalytic reaction of serine palmitoyltransferase2009
- Author(s)
  Shiraiwa, Y., Ikushiro, H., Hayashi, H.
- Journal Title
  
  J. Biol. Chem
  
  Volume: Vol.284 Pages: 15487-15495
- NAID
  110007730458
- Data Source
  KAKENHI-PROJECT-21570120
[Journal Article] Structural insights into the enzymatic mechanism of serine palmitoyltransferase from Sphingobacterium multivorum2009
- Author(s)
  Ikushiro, H., Islam, M. M., Okamoto, A., Hoseki, J., Murakawa, T., Fujii, S., Miyahara, I., Hayashi, H.
- Journal Title
  
  J Biochem
  
  Volume: 146 Pages: 549-562
- NAID
  10026304060
- Data Source
  KAKENHI-PROJECT-21570120
[Journal Article] Quantum mechanical hydrogen tunneling in bacterial copper amine oxidase reaction.2006
- Author(s)
  Murakawa, T., Okajima, T., Kuroda, S., Nakamoto, T., Taki, M., Yamamoto, Y., Hayashi, H., Tanizawa, K.
- Journal Title
  
  Biochem Biophys Res Commun 342
  
  Pages: 414-423
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570125
[Journal Article] Molecular cloning, expression, and characterization of pyridoxamine-pyruvate aminotransferase.2006
- Author(s)
  Yoshikane, Y., Yokochi, N., Ohnishi, K., Hayashi, H., Yagi, T.
- Journal Title
  
  Biochem.J. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570125
[Journal Article] Kinetic and Structural Studies on the Catalytic Role of the Aspartic Acid Residue Conserved in Copper Amine Oxidase.2006
- Author(s)
  Chiu, Y.C., Okajima, T., Murakawa, T., Uchida, M., Taki, M., Hirota, S., Kim, M., Yamaguchi, H., Kawano, Y., Kamiya, N., Kuroda, S., Hayashi, H., Yamamoto, Y., Tanizawa, K.
- Journal Title
  
  Biochemistry 45
  
  Pages: 41055-4120
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570125
[Journal Article] Binding of C5-dicarboxylic substrate to aspartate aminotransferase : implications for the conformational change at the transaldimination step.2005
- Author(s)
  Islam, M.M., Goto, M., Miyahara, I., Ikushiro, H., Hirotsu, K., Hayashi, H.
- Journal Title
  
  Biochemistry 44
  
  Pages: 8218-8229
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570125
[Journal Article] Crystal structure of a putative aspartate aminotransferase belonging to subgroup IV.2004
- Author(s)
  Katsura, Y, Shirouzu, M., Yamaguchi, H., Ishitani, R., Nureki, O., Kuramitsu, S., Hayashi, H., Yokoyama, S.
- Journal Title
  
  Proteins 55
  
  Pages: 487-492
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570125
[Presentation] 銅含有アミン酸化酵素触媒機構の“in crystallo”熱力学的解析2019
- Author(s)
  村川武志，馬場清喜，河野能顕，林秀行，矢野貴人，熊坂崇，山本雅貴，谷澤克行，岡島俊英
- Organizer
  日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K07317
[Presentation] ヒスチジノールリン酸アミノトランスフェラーゼの基質認識機構2018
- Author(s)
  林秀行，村川武志
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-15K05573
[Presentation] In crystallo thermodynamic analysisによる銅アミン酸化酵素の反応機構解析2018
- Author(s)
  村川武志，馬場清喜，河野能顕，林秀行，矢野貴人，熊坂崇，山本雅貴，谷澤克行，岡島俊英，
- Organizer
  酵素補酵素研究会
- Data Source
  KAKENHI-PROJECT-17K07317
[Presentation] トレオニン合成酵素の反応機構2018
- Author(s)
  町田康博，村川武志，境晶子，林秀行
- Organizer
  日本ビタミン学会第70回大会
- Data Source
  KAKENHI-PROJECT-15K05573
[Presentation] レオニン合成酵素における生成物支援機構の理論的解明2016
- Author(s)
  氏家謙、○庄司光男、原田隆平、村川武志、重田育照、林秀行
- Organizer
  第５４回生物物理会年会
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26410002
[Presentation] 2.Analysis of the Catalytic Mechanism of Copper Amine Oxidase from Arthrobacter Globiformis.2016
- Author(s)
  Hiroshi Yamaguchi, Takeshi Murakawa, Misumi Kataoka, Yoshiaki Kawano, Hideyuki Hayashi, Katsuyuki Tanizawa, and Toshihide Okajima.
- Organizer
  ISDSB2016
- Place of Presentation
  Tennessee, USA.
- Year and Date
  2016-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440037
[Presentation] X-ray crystallographic structure of semiquinone radical intermediate formed in bacterial copper amine oxidase.2016
- Author(s)
  Toshihide Okajima, Tadashi Nakai1 , Katsuyuki Tanizawa , Takeshi Murakawa , and Hideyuki Hayashi.
- Organizer
  ICC05-AEM2016
- Place of Presentation
  Unazuki, Japan.
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440037
[Presentation] Strain as the driving force for catalysis in aspartate aminotransferase2016
- Author(s)
  Hideyuki Hayashi and Takeshi Murakawa
- Organizer
  V Russian Congress on Biochemistry
- Place of Presentation
  Sochi, Russian Federation
- Year and Date
  2016-10-04
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05573
[Presentation] Molecular dynamics study on the molecular mechanism of product-assisted catalysis in threonine synthase2015
- Author(s)
  氏家謙，田中弥，庄司光男，原田隆平，栢沼愛，重田育照，村川武志，林秀行
- Organizer
  第43回構造活性相関シンポジウム・第10回薬物の分子設計と開発に関する日中シンポジウム
- Place of Presentation
  新潟
- Year and Date
  2015-09-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24570140
[Presentation] トレオニン合成酵素における生成物支援触媒機構についての理論的解明2015
- Author(s)
  庄司光男，氏家謙，栢沼愛，重田育照，村川武志，林秀行
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  金沢
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-24570140
[Presentation] Energetics of the proton-transfer mechanism in aspartate aminotransferase2015
- Author(s)
  Hideyuki Hayashi, Takeshi Murakawa, Mitsuo Shoji, Yasuteru Shigeta
- Organizer
  Pacifichem 2015
- Place of Presentation
  Honolulu, USA
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05573
[Presentation] Theoretical elucidation on the molecular mechanism of product assited catalysis of threonine synthase2015
- Author(s)
  Mitsuo Shoji, Tuzuru Ujiie, Megumi Kayanuma, Yasuteru Shigeta, Takeshi Murakawa, Hideyuki Hayashi
- Organizer
  The 53rd Annual Meeting of the BSJ
- Place of Presentation
  金沢大学、石川県金沢市
- Year and Date
  2015-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26410002
[Presentation] Molecular dynamics study on the key catalytic intermediates of threonine synthase2015
- Author(s)
  Mitsuo Shoji, Yuzuru Ujiie, Ryuhei Harada, Megumi Kayanuma, Yasuteru Shigeta, Takeshi Murakawa, Hideyuki Hayashi
- Organizer
  The 29th Annual Symposium of the Protein Society
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2015-07-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24570140
[Presentation] Molecular dynamics study on the key catalytic intermediates of threonine synthase2015
- Author(s)
  Mitsuo Shoji, Yuzuru Ujiie, Ryuhei Harada, Megumi Kayanuma, Yasuteru Shigeta, Takeshi Murakawa, Hideyuki Hayashi
- Organizer
  29th Annual Symposium of the Protein Society
- Place of Presentation
  Fira de Barcelona Balcelona, Balcelona , Spain
- Year and Date
  2015-07-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26410002
[Presentation] "Super-closed” structure of aspartate aminotransferase unveils the mechanism for the substate-induced transaldimination process2015
- Author(s)
  Hideyuki Hayashi, Takeshi Murakawa, Ikuko Miyahara
- Organizer
  Biocatalysis-2015
- Place of Presentation
  Moscow, Russia
- Year and Date
  2015-06-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05573
[Presentation] トレオニン合成酵素の反応機構についての理論的研究:反応特異性決定過程の解明2014
- Author(s)
  庄司光男，氏家謙，田中弥，栢沼愛，梅田宏明，町田康博，村川武志，林秀行
- Organizer
  日本化学会第94春季年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24570140
[Presentation] QM/MM study of the L-threonine formation reaction of threonine synthase: mechanism of the product-assisted catalysis2014
- Author(s)
  Mitsuo Shoji, Y.Ujiie, W.Tanaka, M.Kayanuma, R.Harada, H.Umeda, Y.Shigeta, T.Murakawa, H.Hayashi
- Organizer
  computational science workshop 2014 (oral)
- Place of Presentation
  筑波国際会議場、茨城県
- Year and Date
  2014-08-22
- Invited
- Data Source
  KAKENHI-PROJECT-26410002
[Presentation] QM/MM 法によるトレオニン合成酵素の反応制御機構の理論解明2014
- Author(s)
  庄司光男,氏家謙,田中弥,栢沼愛,梅田宏明,村川武,林秀行,重田育照
- Organizer
  理論化学討論会
- Place of Presentation
  名古屋大学、愛知県
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-26410002
[Presentation] トレオニン合成酵素における反応特異性についての理論的解明2013
- Author(s)
  庄司光男，氏家謙，田中弥，花岡恭平，梅田宏明，栢沼愛，神谷克政，白石賢二，町田康博，村川武志，林秀行
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24570140
[Presentation] 分子動力学法によるトレオニン合成酵素の反応特異性についての理論的解明2013
- Author(s)
  氏家謙，田中弥，花岡恭平，庄司光男，栢沼愛，神谷克政，白石賢二，町田康博，村川武志，林秀行
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24570140
[Presentation] トレオニン合成酵素における反応特異性決定過程の理論解明2013
- Author(s)
  庄司光男，花岡恭平，氏家謙，田中弥，梅田宏明，栢沼愛，神谷克政，白石賢二，町田康博，村川武志，林秀行
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-24570140
[Presentation] トレオニン合成酵素におけるリン酸脱離以降の反応機構についての理論的解明2012
- Author(s)
  庄司光男，花岡恭平，近藤大生，田口真彦，栢沼愛，梅田宏明，鴨志田良和，神谷克政，白石賢二，村川武志，林秀行
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24570140
[Presentation] トレオニン合成酵素の触媒性リン酸イオン結合残基の役割2012
- Author(s)
  町田康博，村川武志，庄司光男，林秀行
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24570140
[Presentation] Product-assisted catalysis is the basis of the reaction specificity of threonine synthase2011
- Author(s)
  Hideyuki Hayashi
- Organizer
  The Third International Conference on Cofactors
- Place of Presentation
  University of Turku, Turku, Finland
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-21570120
[Presentation] 生成物支援触媒によってもたらされる酵素の反応特異性2011
- Author(s)
  村川武志, 林秀行
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  吹田
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-21570120
[Presentation] Acid-base chemistry of the catalytic reaction of the bacterial copper amine oxidase2011
- Author(s)
  村川武志, 岡島俊英, 濱口章央, 谷澤克行, 林秀行
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-21570120
[Presentation] 銅含有アミン酸化酵素の触媒機構:酸化的半反応中間体の立体構造解析2010
- Author(s)
  喜久川政吾, 岡島俊英, 濱口章央, 村川武志, 林秀行, 谷澤克行
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21570120
[Presentation] トレオニン合成酵素の分光学的および速度論的解析2010
- Author(s)
  村川武志, 林秀行
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21570120
[Presentation] 銅アミン酸化酵素反応はトパセミキノンラジカル中間体を経由して進行する2009
- Author(s)
  濱口章央, 岡島俊英, 谷澤克行, 村川武志, 林秀行
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-21570120
[Presentation] 速度論および構造解析に基づく酵素触媒反応におけるプロトントンネリング機構の解析2009
- Author(s)
  村川武志, 岡島俊英, 谷澤克行, 林秀行
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-21570120
[Presentation] QM/MM study on the L-threonine formation reaction of threonine synthase
- Author(s)
  Mitsuo Shoji, Yuzuru Ujiie, Wataru Tanaka, Megumi Kayanuma, Ryuhei Harada, Hiroaki Umeda, Yasuteru Shigeta, Takeshi Murakawa, Hideyuki Hayashi
- Organizer
  QSCP XIX
- Place of Presentation
  Tamkang University, Taipei, Taiwan
- Year and Date
  2014-11-11 – 2014-11-17
- Data Source
  KAKENHI-PROJECT-26410002
[Presentation] 銅アミン酸化酵素のTPQ生成反応と触媒反応における保存性Asn残基の役割
- Author(s)
  村川武志，中西将太，元山暁仁，林秀行，谷澤克行，岡島俊英
- Organizer
  日本蛋白質科学会
- Place of Presentation
  横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26440037
[Presentation] トレオニン合成酵素における生成物支援触媒機構解明のための精密自由エネルギー計算
- Author(s)
  庄司光男, 氏家謙, 田中弥, 栢沼愛, 梅田宏明, 重田育照, 村川武志, 林秀行
- Organizer
  日本生化学会大会(ポスター)
- Place of Presentation
  京都国際会議場、京都府
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26410002
[Presentation] トレオニン合成酵素の触媒反応前半部分の反応機構解析
- Author(s)
  町田康博，村川武志，庄司光男，林秀行
- Organizer
  第61回日本生化学会近畿支部例会
- Place of Presentation
  京都
- Year and Date
  2014-05-17 – 2015-05-17
- Data Source
  KAKENHI-PROJECT-24570140
[Presentation] 銅アミン酸化酵素のTPQ補酵素とその前駆体Tyr残基のコンフォメーション制御の分子機構
- Author(s)
  村川武志，中西将太，元山暁仁，林秀行，谷澤克行，岡島俊英
- Organizer
  日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26440037
[Presentation] Conformational flexibility of the topa quinone cofactor in copper amine oxidase revealed by site-specific mutagenesis of the neighboring conserved asparagine residue
- Author(s)
  Takeshi Murakawa, Hideyuki Hayashi, Katsuyuki Tanizawa, Toshihide Okajima
- Organizer
  ICC-04
- Place of Presentation
  イタリア，パルマ
- Year and Date
  2014-08-24 – 2014-08-30
- Data Source
  KAKENHI-PROJECT-26440037
[Presentation] トレオニン合成酵素の触媒過程前半部分の解析
- Author(s)
  林秀行，村川武志，庄司光男
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  船橋
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24570140

1. TAKESHI Murakawa (90445990)

# of Collaborated Projects: 6 results

# of Collaborated Products: 40 results
2. HIROTSU Ken (10047269)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. Shoji Mitsuo (00593550)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
4. 原三郎 (00028193)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 林加恵子 (00214544)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. KAGAMIYAMA Hiroyuki (80028555)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. YANO Takato (40239827)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KURAMITSU Seiki (60153368)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 馬場清喜 (00437344)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
10. KIRSCH J.F.

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. IKUSHIRO Hiroko (10280702)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
12. MORINO Yoshimasa (30028352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TANASE Sumio (20112401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YOSHIHARA Yoshihiro (20220717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MORI Kensaku (60008563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NODA Tetsuo (10183550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TORAYA Tetsuo (50135597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HAYASHI Katsuyuki (20133134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. TORAYA Tetsuo (70026318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SHIMADA Hideo (80095611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. MIZUGUCHI Hiroyuki (40247838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YAMAMOTO Daisuke (50240106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
23. 樋口泰一 (40046868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 堀池喜八郎 (80089870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 三浦洌 (70093466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 石井誠志 (10247851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 藤橋雅宏 (10397581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. ARNONE A.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. METZLER D.E.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. FUJITA Hiroko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. JISHAGE Kouichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. UJIIE YUZURU

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
33. TANAKA WATARU

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
34. 川崎美和

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 岡島俊英

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
36. 三上文三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Hideyuki 林 秀行

HAYASHI Hideyuki 林 秀行

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Concerted proton/electron transfer mechanism in cofactor-dependent enzymePrincipal Investigator

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Reaction specificity of pyridoxal enzymesPrincipal Investigator

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Multidimensional energy analysis of pyridoxal-enzyme and quinoenzyme reactionsPrincipal Investigator

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Studies on the proton transfer processes in pyridoxal enzymesPrincipal Investigator

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Designing composite biocatalysts by analysis of the proton-transfer process in pyridoxal enzymesPrincipal Investigator

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Proton-transfer mechanism of pyridoxal enzymes studied by 3D-free energy profilePrincipal Investigator

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The proton-transfer mechanism of the catalytic reactions of pyridoxal enzymesPrincipal Investigator

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Hayashi Hideyuki 林秀行

HAYASHI Hideyuki 林秀行

[Book] タンパク質科学第9章触媒機能(後藤祐児・桑島邦博・谷澤克行編)2005