YAMAGUCHI Kazuhiko 山口和彦

Researcher Number	00191221
Affiliation *help	2017 : 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 2013 : 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 2010 – 2012 : The Institute of Physical and Chemical Research, 運動学習制御研究チーム, 副チームリーダー 2010 – 2011 : The Institute of Physical and Chemical Research, 研究員 2008 – 2009 : The Institute of Physical and Chemical Research, 記憶学習機構研究チーム, 副チームリーダー … More
Research Field	Principal Investigator Neurophysiology and muscle physiology / 神経・脳内生理学 / Basic / Social brain science / Neurophysiology and muscle physiology / Neurophysiology and muscle physiology Except Principal Investigator 神経・脳内生理学 / Cell biology / Neuroscience in general
Keywords	Principal Investigator 海馬 / シナプス可塑性 / 小脳 / シンタキシン / 長期抑圧 / オ-タプス / パッチクランプ法 / 後根神経節 / アラキドン酸 / 運動学習 … More Except Principal Investigator HPC-1 / 海馬 / catenin / リソホスファチジン酸 / カドヘリン / 制御性分泌 / adhesion molecule / 接着力 / NEURITE SPROUTING / 培養神経細胞 / シンタキシン / 神経可塑性 / 細胞間接着力 / マイクロピペット / シナプス小胞 / 最初期遺伝子 / 脊髄後根神経節 / 神経発芽 / カテニン / 出芽 / アンチセンスオリゴヌクレオチド / 接着分子 / cell adhesion / 神経突起末端部 / micropipet / ホスファチジン酸 / リン脂質 / リゾホスファチジン酸 / 張力 / パッチクランプ法 / cadherin / 開口放出 / ホールセル・クランプ法 / 長期増強 / physiology / EXOCYTOSIS / 脊髄後根神経節細胞 / 単離培養系 / カイニン酸 / アンチセンスDNA / ホスファチジル酸 / 細胞接着 / シナプトファイシン / Caチャネル / SYNTAXIN 1A / REGULATED SECRETION / シナプス伝達 Less

Elucidation of motor learning strategy via two types of the cerebellar synaptic plasticityPrincipal InvestigatorOngoing
- Principal Investigator
  
  山口和彦
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic / Social brain science
- Research Institution
  Institute of Physical and Chemical Research
Elucidation of molecular mechanism of synaptic plasticity by kinetic analysis of receptor traffickingPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Kazuhiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  The Institute of Physical and Chemical Research
Elucidation of regulatory mechanism of AMPA-receptor's trafficking by visualization of its intracellular pool.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI Kazuhiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  The Institute of Physical and Chemical Research
新規リソホスファチジル酸アシル基転移酵素エンドフィリンのシナプス伝達における役割
- Principal Investigator
  
  根本康夫
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
  The Institute of Physical and Chemical Research
Elucidation of molecular mechanism of synaptic exocytosis and its modification mechanism in mammalian hippocampal autapse.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI Kazuhiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Kyorin University
培養神経細胞を用いたシナプス抑圧退行物質の検索と作用機構の解明Principal Investigator
- Principal Investigator
  
  山口和彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyorin University
STUDY OF A NEURON-SPECIFIC PROTEIN,HPC-1, WHICH REGULATES NEURONAL SPROUTING.
- Principal Investigator
  
  AKAGAWA Kimio
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  KYORIN UNIVERSITY
培養神経細胞を用いたシナプス抑圧退行物質検索の為の検定系の開発Principal Investigator
- Principal Investigator
  
  山口和彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyorin University
神経突起末端部における神経細胞膜蛋白質HPC-1の機能に関する生理学的研究Principal Investigator
- Principal Investigator
  
  山口和彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Kyorin University
培養した痛覚系1次求心神経細胞の神経突起末端部膜の生理学的、薬理学的性質Principal Investigator
- Principal Investigator
  
  山口和彦
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyorin University
活性ゾーソの有無に注目した逆行性伝達物質検定のための神経培養系の開発Principal Investigator
- Principal Investigator
  
  山口和彦
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyorin University
Direct Measurement of Cell-Cell Adhesion
- Principal Investigator
  
  YONEMURA Sigenobu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  National Institute for Physiological Sciences
シナプス前膜蛋白質に対するアンチセンスDNA等を用いた神経伝達物質放出機構の解析Principal Investigator
- Principal Investigator
  
  山口和彦
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Kyorin University
人為的に形成させた培養中枢神経細胞間シナプスを用いた逆行性情報伝達物質の検定Principal Investigator
- Principal Investigator
  
  山口和彦
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okazaki National Research Institutes
Investigation of the molecular mechanism of the neurite-outgrowth using a contrast enhanced camera and intracellular perfusion methods.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI Kazuhiko
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Okazaki National Research Institutes National institute for Physiological Sciences Grant-in-Aid for Scientific Research (C)

All 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] 分子・細胞・シナプス2008
- Author(s)
  山口和彦
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-20500363
[Journal Article] Long-term depression as a model of cerebellar plasticity2014
- Author(s)
  Ito M, yamaguchi K, Nagao S, Yamazaki, T.
- Journal Title
  
  Progress in Brain research
  
  Volume : 210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500472
[Journal Article] Long-term depression as a model of cerebellar plasticity2014
- Author(s)
  Ito M, Yamaguchi K, Nagao S, Yamazaki T
- Journal Title
  
  Progress in Brain Research
  
  Volume : (in press)
- Data Source
  KAKENHI-PROJECT-23500472
[Journal Article] CRMP5(collapsin response mediator protein 5) regulates dendritic development and synaptic plasticity in the cerebellar Purkinje cells2011
- Author(s)
  Yamashita N, Mosinger B, Roy A, Miyazaki M, Ugajin K, Nakamura F, Sasaki Y, Yamaguchi K, Kolattukudy P, Goshima Y.
- Journal Title
  
  Journal of Neuroscience
  
  Volume : 31(5) Pages : 1773-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700411, KAKENHI-PROJECT-22500336, KAKENHI-PROJECT-23500472
[Journal Article] CRMP5 (Collapsin Response Mediator Protein 5) regulates dendritic development and synaptic plasticity in the cerebellar2011
- Author(s)
  Yamashita N, Mosinger B, Roy A, Miyazaki M, Ugajin K, Nakamura F, Sasaki Y, Yamaguchi K, Kolattukudy P, Goshima Y
- Journal Title
  
  Purkinje cell.J.Neurosci. 31
  
  Pages : 1773-1779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500363
[Journal Article] Remodeling of Monoplanar Purkinje Cell Dendrites during Cerebellar Circuit Formation.2011
- Author(s)
  Kaneko, M., Yamaguchi, K., Eiraku, M., Sato, M., Takata, N., Kiyohara, Y., Mishina, M., Hirase, H., Hashikawa, T. and Kengaku, M
- Journal Title
  
  PloS one
  
  Volume : 6 Issue : 5
- Publisher
  Public Library of Science
- PMID
  21655286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249012, KAKENHI-PLANNED-22123008, KAKENHI-PROJECT-23500472, KAKENHI-PROJECT-23700399
[Journal Article] RNG105 deficiency impairs the dendritic localization of mRNAs for Na^+/K^+ ATPase subunit isoforms and leads to the degeneration of neuronal networks.2010
- Author(s)
  Shiina N, Yamaguchi K, Tokunaga M
- Journal Title
  
  J.Neurosci 30
  
  Pages : 12816-12830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500363
[Journal Article] Dual involvement of G-substrate in motor learning revealed by gene deletion.2009
- Author(s)
  Endo S., Shuto F., Le D.T., Okamoto T., Ikeda T., Suzuki M., Kawahara S., Yanagihara D., Sato Y., Yamada K., Sakamoto T., Kirino Y., Hartell N.A., Yamaguchi K., Itohara S., Naim A., Greengarg P., Nagao S., Ito M.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages : 3525-3530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500363
[Journal Article] Connexin43 and Bergmann glial gap junctions in cerebellar function.2008
- Author(s)
  Tanaka M, Yamaguchi K, Tatsukawa T, Theis M, Willecke K, Itohara S
- Journal Title
  
  Front Neurosci. 2(2)
  
  Pages : 225-233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500363
[Journal Article] Lack of connexin43-mediated Bergmann glial gap junctional coupling does not affect cerebellar long-term depression, motor coordination or eyeblink conditioning.2008
- Author(s)
  Tanaka M., Yamaguchi K., Tatsukawa T., Nishioka C., Nishiyama H., Theis M., Willecke K., Itohara S.
- Journal Title
  
  Front.Behav.Neurosci. 2
  
  Pages : 1-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] 小脳プルキンエ細胞長期抑圧で内在化した AMPA 受容体の細胞内分布2014
- Author(s)
  山口和彦
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島
- Year and Date
  2014-03-17
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] Nitric oxide dependent change in AMPA receptor trafficking in Purkinje cell analysed using a kinetic model of receptor trafficking2014
- Author(s)
  Yamaguchi K
- Organizer
  the 37th Congress of the International Union of Physiological Sciences (IUPS 2013)
- Place of Presentation
  Birmingham UK
- Year and Date
  2014-03-17
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] 受容体側方拡散の小脳プルキンエ細胞シナプスにおけるAMPA受容体トラフィッキングへの寄与2013
- Author(s)
  山口　和彦
- Organizer
  生理学研究所　研究会　「シナプス・神経ネットワークの機能ダイナミクス」
- Place of Presentation
  岡崎　　　　　　愛知
- Invited
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] 小脳平行線維-プルキンエ細胞間シナプスにおける AMPA 受容体トラフィッキングに対する側方拡散の寄与2013
- Author(s)
  山口和彦, 永雄総一
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] ケージ化阻害ペプチドを用いた受容体トラフィッキングのキネティック解析により解明された小脳LTDにおけるAMPA受容体エキソサイトーシスの抑制2012
- Author(s)
  Yamaguchi K, Nagao S.
- Organizer
  第89回日本生理学会大会シンポジウム
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] Change in trafficking kinetics of AMPA-receptor underlying LTD revealed by photolysis of caged inhibitory peptide in cerebellar Purkinje cell2012
- Author(s)
  Yamaguchi, K. Nagao, S
- Organizer
  8th Federation of European Neuroscience Forum of Neuroscience
- Place of Presentation
  Barcelona Spain
- Year and Date
  2012-07-16
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] Suppression of AMPA-receptor endocytosis is the mechanism underlying LTP at the parallel fiber-Purkinje cell synapse.2012
- Author(s)
  Yamaguchi K, Nagao S.
- Organizer
  International Synapse Research Workshop 2012 Understanding of synapse pathology, from genome mutation to functional defects.
- Place of Presentation
  Okazaki, Japan
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] 小脳平行線維プルキンエ細胞間シナプス長期増強におけるAMPA 受容体トラフィッキングのキネティック解析2012
- Author(s)
  山口和彦, 永雄総一
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] ケージ化阻害ペプチドを用いた受容体トラフィッキングのキネティック解析により解明された小脳 LTD における AMPA 受容体エキソサイトーシスの抑制2012
- Author(s)
  山口和彦, 永雄総一
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] An analysis based on a data-driven kinetic model of receptor-trafficking in cerebellar Purkinje cell predicts insufficiency of receptor-destabilization as a mechanism of LTD.2011
- Author(s)
  Yamaguchi, K., Nagao, S.
- Organizer
  The 11th Japan-Korea-China Joint Workshop on Neurobiology and Neuroinformatics
- Place of Presentation
  Okinawa Japan
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] AMPA型受容体エクソサイトーシスの活動依存性抑圧の平行線維－プルキンエ細胞間シナプスにおける長期抑圧発現への関与.2011
- Author(s)
  山口和彦、達　吉郎、永雄総一
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] Activity-dependent Change in AMPA-Receptor Trafficking Investigated by Photolysis of a Caged Inhibitory Peptide in Cerebellar Purkinje Cell.2011
- Author(s)
  Yamaguchi.K, Tatsu Y, Nagao S. Ito M.
- Organizer
  8th IBRO World Congress of Neurosci.
- Place of Presentation
  Florence Italy
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] Multi-site modulation of AMPA-receptor trafficking during cerebellar LTD.2011
- Author(s)
  Yamaguchi K and Nagao S.
- Organizer
  4th International Symposium of the Society for Research on the Cerebellum
- Place of Presentation
  Tokyo Japan
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] 小脳プルキンエ細胞における構成性および活動依存性 AMPA 受容体トラフィッキングのデータ駆動性キネティックモデル2011
- Author(s)
  山口和彦, 達吉郎, 永雄総一
- Organizer
  第88回日本生理学会大会
- Place of Presentation
  横浜
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] Activity-dependent Change in AMPA- receptor trafficking investigated by photolysis of a caged inhibitory peptide in cerebellar Purkinje cell2011
- Author(s)
  Yamaguchi.K, Tatsu Y, Nagao S. Ito M
- Organizer
  8th IBRO World Congress of Neurosci
- Place of Presentation
  Florence Italy
- Year and Date
  2011-07-16
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] Multi-site modulation of AMPA-receptor trafficking during cerebellar LTD2011
- Author(s)
  Yamaguchi K and Nagao S
- Organizer
  4th International Symposium of the Society for Research on the Cerebellum
- Place of Presentation
  Tokyo
- Year and Date
  2011-09-18
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] An analysis based on a data-driven kinetic model of receptor-trafficking in cerebellar Purkinje cell predicts insufficiency of receptor-destabilization as a mechanism of LTD2011
- Author(s)
  Yamaguchi, K., Nagao, S
- Organizer
  The 11th Japan-Korea- China Joint Workshop on Neurobiology and Neuroinformatics
- Place of Presentation
  Okinawa
- Year and Date
  2011-12-18
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] AMP 型受容体エクソサイトーシスの活動依存性抑圧の平行線維-プルキンエ細胞間シナプスにおける長期抑圧発現への関与2011
- Author(s)
  山口和彦, 達吉郎, 永雄総一
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] Lrfn2/SALM1 regulates excitatory synapse function in the hippocampus and its deficient mice display mental disorder-like behavioral abnormalities2011
- Author(s)
  Morimura N, Yasuda H, Yamada K, Tomioka N, Katayama K, Yamaguchi K, Ota M, Kamiya A, Aruga J
- Organizer
  Symposium : Emerging synapse organizers in hippocampal neural circuits 34th Ann. Meeting of Jpn Neurosci. Soc
- Place of Presentation
  Yokohama
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] 小脳プルキンエ細胞におけるGluR2細胞内プールの活動依存性トランスロケーションとシナプス可塑性:蛍光蛋白質2重発現法による解析2010
- Author(s)
  山口和彦
- Organizer
  生理学研究所研究会"シナプス伝達の概念志向型研究"
- Place of Presentation
  岡崎
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] Effects of LTD-Inducing Stimulation on Endocytic Rate-Constant of AMPA-Receptor Trafficking at Parallel Fiber-Purkinje Cell Synapse in Cerebellum2010
- Author(s)
  Yamaguchi K, Nagao S
- Organizer
  生理学研究所研究会"記憶学習行動の基盤としてのシナプス可塑性"
- Place of Presentation
  岡崎
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] Attenuation of cerebellar plasticity after neonatal perturbation of NMDA receptors in the vestibular nucleus2010
- Author(s)
  Lai SK, Yamaguchi K, Yung WH, Chan YS
- Organizer
  Poster 5^<th> Congress of FAONS and XXVIII Annual Meeting of IAN.
- Place of Presentation
  Lucknow India
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] AMPA-receptor trafficking in cerebellar Purkinje cell : A kinetic analysis. Symposium "Neural circuit : Develop and Plasticity"2010
- Author(s)
  山口和彦
- Organizer
  5^<th> Congress of FAONS and XXVIII Annual Meeting of IAN.
- Place of Presentation
  Lucknow India
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] Perinatal perturbation of NMDA receptor in the vestibular nucleus attenuates cerebellar function.2010
- Author(s)
  Lai SK, Shum DKY, Yung WH, Yamaguchi K, Chan YS
- Organizer
  The 40th annual meeting of the Society for Neuroscience
- Place of Presentation
  San Diego USA
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] 小脳プルキンエ細胞GluR2細胞内プールの樹状突起スパインからシャフトへの活動依存性移動の蛍光蛋白質2重発現法による解析2010
- Author(s)
  山口和彦, 他
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] 小脳プルキンエ細胞におけるGluR2細胞内プールの活動依存性トランスロケーションとシナプス可塑性:蛍光蛋白質2重発現法による解析2010
- Author(s)
  山口和彦, 他
- Organizer
  生理学研究所研究会"シナプス伝達の概念志向型研究"
- Place of Presentation
  生理学研究所岡崎
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] ケージドペプチドを用いた小脳平行線維プルキンエ細胞間シナプスにおけるAMPA受容体トラフィッキングの速度定数の計測2010
- Author(s)
  山口和彦, 他
- Organizer
  第33回日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] Effects of LTD-Inducing Stimulation on Endocytic Rate-Constant of AMPA-Receptor Trafficking at Parallel Fiber-Purkinje Cell Synapse in Cerebellum2010
- Author(s)
  Yamaguchi K., et al.
- Organizer
  生理学研究所研究会"記憶学習行動の基盤としてのシナプス可塑性"
- Place of Presentation
  生理学研究所岡崎
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] AMPA-receptor trafficking in cerebellar Purkinje cell : A kinetic analysis using a whole-cell recording technique.2010
- Author(s)
  Yamaguchi K.
- Organizer
  IBRO School of Neuroscience in Hong Kong
- Place of Presentation
  Chinese University of Hong Kong, Hong Kong
- Year and Date
  2010-06-02
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] AMPA-receptor trafficking in cerebellar Purkinje cell : A kinetic analysis.2010
- Author(s)
  Yamaguchi K.
- Organizer
  Symposium "Neural circuit : Develop and Plasticity" 5^<th> Congress of Federation of Asia-Oceania Neuroscience (FAONS)
- Place of Presentation
  Hotel Clarks Avadh, Lucknow, India
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] ケージドペプチドを用いた小脳平行線維プルキンエ細胞間シナプスにおけるAMPA受容体トラフィッキングの速度定数の計測2010
- Author(s)
  山口和彦、達吉郎、永雄総一、伊藤正男
- Organizer
  第33回日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] Involvement of actin-myosin interaction in cerebellar long-term depression2010
- Author(s)
  Tatsukawa T, Nagao S, Yamaguchi K
- Organizer
  The 40th annual meeting of the Society for Neuroscience
- Place of Presentation
  San Diego USA
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] 小脳プルキンエ細胞GluR2細胞内プールの樹状突起スパインからシャフトへの活動依存性移動の蛍光蛋白質2重発現法による解析2010
- Author(s)
  山口和彦、清水知佳、中澤敬信、伊藤正男
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] AMPA-receptor trafficking in cerebellar Purkinje cell : A kinetic analysis using a whole-cell recording technique.2010
- Author(s)
  山口和彦
- Organizer
  IBRO School of Neuroscience Chinese University of Hong Kong
- Place of Presentation
  Hong Kong
- Year and Date
  2010-06-02
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] An integrative kinetic model of AMPA-receptors constitutive trafficking and LTD/LTP in cerebellar Purkinje cell2009
- Author(s)
  山口和彦
- Organizer
  36^<th> International Congress of Physiological Sciences
- Place of Presentation
  (国立京都国際会館)京都
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] Translocation of GluR2 pool in the dendritic spine of cerebellar Purkinje cells under long-term depression2009
- Author(s)
  Yamaguchi K, Shimizu C, Sato Y, Furuichi T, Ito M.
- Organizer
  39^<th> annual meeting of Society for Neuroscience
- Place of Presentation
  Chicago IL USA
- Year and Date
  2009-10-19
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] プルキンエ細胞樹状突起スパインにおけるGluR2細胞内プールの活動依存性移動へのPKCの関与2009
- Author(s)
  山口和彦
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  (名古屋国際会議場)名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] Translocation of GluR2 pool in the dendritic spine of cerebellar Purkinje cells under long-term depression.2009
- Author(s)
  Yamaguchi K, Shimizu C, Sato Y, Furuichi T, Ito M
- Organizer
  The 39^<th> annual meeting of the Society for Neuroscience
- Place of Presentation
  Chicago USA
- Year and Date
  2009-10-19
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] プルキンエ細胞樹状突起スパインにおけるGluR2細胞内プールの活動依存性移動へのPKCの関与2009
- Author(s)
  山口和彦
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] An integrative kinetic model of AMPA-receptors constitutive trafficking and LTD/LTP in cerebellar2009
- Author(s)
  山口和彦
- Organizer
  Purkinje cell 36^<th> International Congress of Physiological Sciences
- Place of Presentation
  京都
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] AMPA受容体トラフィッキングのキネティックスとシナプス可塑性2009
- Author(s)
  山口和彦
- Organizer
  神経組織の成長・再生・移植研究会題24回学術集会
- Place of Presentation
  伊香保
- Year and Date
  2009-06-21
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] AMPA受容体トラフィッキングのキネティックスとシナプス可塑性2009
- Author(s)
  山口和彦
- Organizer
  神経組織の成長・再生・移植研究会第24回学術集会
- Place of Presentation
  (ホテル天坊)群馬県伊香保
- Year and Date
  2009-06-21
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] 小脳プルキンエ細胞におけるAMPA受容体トラフィッキングの速度論的解析とLTP/LTDのメカニズム2008
- Author(s)
  山口和彦
- Organizer
  生理学研究所研究会シナプス研究会"シナプス成熟と可塑性のダイナミクス"
- Place of Presentation
  岡崎
- Year and Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] LRR膜貫通分子Lrfn2/SALM1は海馬興奮性シナプスの形態や機能調節および可塑性に関与する2008
- Author(s)
  守村直子、山口和彦、安田浩樹、片山圭一、原直子、太田摩耶、神谷明子、有賀純
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] Roles of actin in constitutive and activity-dependent trafficking of AMPA-receptors in the cerebellar Purkinje cell.2008
- Author(s)
  山口和彦
- Organizer
  US-Japan Brain Research Collaborative Program. Workshop on Receptor Trafficking and Cell Biology of Neurons : Physiology and Disease.
- Place of Presentation
  Pacific Grove USA
- Year and Date
  2008-02-26
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] アラキドン酸はアストロサイトの接触によって誘発されるシナプス形成のカギをにぎる2008
- Author(s)
  濱裕、安藤亮子、山口和彦、宮脇敦史
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] プルキンエ細胞におけるAMPA受容体双方向性トラフィッキングとモデルによる考察2008
- Author(s)
  山口和彦
- Organizer
  生理学研究所研究会"新たなコンセプトでシナプス伝達を考える"
- Place of Presentation
  岡崎
- Year and Date
  2008-09-18
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] 小脳プルキンエ細胞樹状突起におけるグルタミン酸受容体の活動依存性分布変化2008
- Author(s)
  山口和彦、清水知佳、佐藤友美、古市貞一、伊藤正男
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] 小脳プルキンエ細胞樹状突起スパインにおけるアンパ受容体分布変化と長期抑圧2008
- Author(s)
  山口和彦、清水知佳、佐藤友美、古市貞一、伊藤正男
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] 小脳プルキンエ細胞樹状突起スパインにおけるAMPA受容体分布変化と長期抑圧2008
- Author(s)
  山口和彦
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] RNG105 deficiency impairs the denderitic transport on Na+/K+-ATPase subunit isoform mRNA and the formation of synapses and neuronal networks.2008
- Author(s)
  Shiina N, Yamaguchi K, Tokunaga M
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20500363
[Presentation] Changes in kinetic parameters of receptor trafficking underlying synaptic plasticity in cerebellum
- Author(s)
  Yamaguchi K.
- Organizer
  Molecular and Cellular Cognition Society (MCCS-Asia 6th Annual Meeting in Kyoto
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] Nitric oxide dependent change in AMPA receptor trafficking in Purkinje cell analysed using a kinetic model of receptor trafficking
- Author(s)
  Yamaguchi K.
- Organizer
  the 37th Congress of the International Union of Physiological Sciences (IUPS 2013)
- Place of Presentation
  Birmingham UK
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] 小脳プルキンエ細胞長期抑圧で内在化したAMPA受容体の細胞内分布
- Author(s)
  山口　和彦
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] Change in trafficking kinetics of AMPA-receptor underlying LTD revealed by photolysis of caged inhibitory peptide in cerebellar Purkinje cell
- Author(s)
  Yamaguchi, K. Nagao, S.
- Organizer
  8th Federation of European Neuroscience Forum of Neuroscience
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] Kinetic analysis of AMPA type glutamate receptors trafficking upon LTP at the parallel fiber-Purkinje cell synapse in cerebellum
- Author(s)
  Yamaguchi K, Nagao S.
- Organizer
  35th Anual Meeting of Jpn Society for Neuroscience
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-23500472
[Presentation] Suppression of AMPA-receptor-exocytosis during cerebellar LTD revealed by kinetic analysis of receptor trafficking using caged inhibitory peptide
- Author(s)
  Yamaguchi K, Nagao S.
- Organizer
  Symposium "Chemical neurobiology" 89th Annual Meeting of Jpn Physiol. Soc.
- Place of Presentation
  Matsumoto, Japan
- Data Source
  KAKENHI-PROJECT-23500472

1. AKAGAWA Kimio (80129303)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
2. YONEMURA Sigenobu (60192811)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
3. NAGAFUCHI Akira (80218023)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
4. TSUKITA Sachiko (00188517)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
5. OSANAI Makoto (90286419)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
6. FUJIWARA Tomonori (90255399)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. FUJINO Ichiro (30265764)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. 根本康夫 (30250088)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. YAMASHITA Naoya

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
10. SASAKI Yukio

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
11. GOSHIMA Yoshio

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
12. MISHINA Masayoshi

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
13. HIRASE Hajime

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
14. TAKATA Norio

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

YAMAGUCHI Kazuhiko 山口 和彦

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Elucidation of motor learning strategy via two types of the cerebellar synaptic plasticityPrincipal InvestigatorOngoing

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Elucidation of molecular mechanism of synaptic plasticity by kinetic analysis of receptor traffickingPrincipal Investigator

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Elucidation of regulatory mechanism of AMPA-receptor's trafficking by visualization of its intracellular pool.Principal Investigator

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新規リソホスファチジル酸アシル基転移酵素エンドフィリンのシナプス伝達における役割

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Elucidation of molecular mechanism of synaptic exocytosis and its modification mechanism in mammalian hippocampal autapse.Principal Investigator

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培養神経細胞を用いたシナプス抑圧退行物質の検索と作用機構の解明Principal Investigator

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STUDY OF A NEURON-SPECIFIC PROTEIN,HPC-1, WHICH REGULATES NEURONAL SPROUTING.

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培養神経細胞を用いたシナプス抑圧退行物質検索の為の検定系の開発Principal Investigator

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神経突起末端部における神経細胞膜蛋白質HPC-1の機能に関する生理学的研究Principal Investigator

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培養した痛覚系1次求心神経細胞の神経突起末端部膜の生理学的、薬理学的性質Principal Investigator

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活性ゾーソの有無に注目した逆行性伝達物質検定のための神経培養系の開発Principal Investigator

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Direct Measurement of Cell-Cell Adhesion

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シナプス前膜蛋白質に対するアンチセンスDNA等を用いた神経伝達物質放出機構の解析Principal Investigator

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人為的に形成させた培養中枢神経細胞間シナプスを用いた逆行性情報伝達物質の検定Principal Investigator

Principal Investigator

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YAMAGUCHI Kazuhiko 山口和彦