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MOTOKURA Toru  本倉 徹

ORCIDConnect your ORCID iD *help
Researcher Number 00192823
Other IDs
Affiliation (based on the past Project Information) *help 2007: Tottori University, Faculty of Medicine, Associate Professor
2002 – 2006: FACULTY OF MEDICINE, Lecturer, 医学部附属病院, 講師
2001: 東京大学, 医学部・附属病院, 助手
2001: Tokyo Univ., Dept. of Medicine Prof., 医学部・附属病院, 講師
1998 – 2000: The University of Tokyo, Faculty of Medicine Branch Hospital Assistant Professor, 医学部・附属病院分院, 助手 … More
1997: 東京大学, 医学部附属病院分院, 助手
1995 – 1996: 東京大学, 医学部・附属病院(分), 助手
1995: 東京大学, 医学部附属病院(分), 助手
1993 – 1995: 東京大学, 医学部(分), 助手
1994: 東京大学, 医学部, 助手
1989: Fourth Department of Internal Medicine, University of Tokyo, School of Medicine, Instructor and Research Associate, 医学部(分), 助手
1988 – 1989: 東京大学, 医学部, 助手
1987: 東京大学, 医学部(分), 助手 Less
Review Section/Research Field
Principal Investigator
Hematology / Hematology
Except Principal Investigator
Hematology / Endocrinology / Clinical nursing
Keywords
Principal Investigator
サイクリン / 細胞周期 / 癌遺伝子 / 血液系腫瘍 / 造血 / p16INK4a / p53 / 自然選択 / ARF / natural selection … More / p21CIP1 / p27KIP1 / 多段階発がん / r選択 / K選択 / MDR1 / 多剤耐性 / Myc / Ras / 14-3-3 / 分化 / PCR / 巨核球 / 腫瘍化 / p21WAF1 / HEMATOPOIESIS / CELL CYCLE / CYCLIN / MEGAKARYOCYTE / TUMORIGENESIS / 造血器腫瘍 / がん抑制遺伝子 / INK4 / rとK選択 / p14ARF / cell cycle / hematological malignancies / tumor suppressor / INK4A / r- and K-selection / multistep oncogenesis / r-selection / K-selection / p-glycoprotein / multidrug resistance / P糖蛋白 / 薬剤耐性 / DNAメチル化 / c-myc / ras / multistep tumorigenesis / P-glycoprotein / drug resistance / DNA methylation / 遺伝子 / ウイルス / 癌 / 疾患モデル / Gene / virus / malignancy / disease model / 成人T細胞白血病 / 高カルシウム血症 / 副甲状腺ホルモン関連淡泊 / 副甲状腺ホルモン関連蛋白 / 副甲状線ホルモン関連蛋白 / cDNAクローニング / 副甲状腺ホルモン / adult T-cell leukemia-lymphoma / hypercalcemia / parathyroid hormone-related protein … More
Except Principal Investigator
G蛋白質 / レセプター / 分子機構 / G蛋白質病 / 遺伝子治療 / Notch / Jagged1 / アクチビンA / マウスフレンド細胞 / HMBA(Hexamethylene Bis acetamide) / トロンボキサン / 巨核球 / 赤芽球 / HLー60細胞 / インターフェロンーgamma / アクチビン / ストローマ細胞 / basic FGF / PDGF / TGF-β / アクチビンレセプター / 副甲状腺ホルモン関連ペプチド / がん遺伝子 / ras / p53 / がん化 / 高カルシウム血症 / 白血病 / 悪性リンパ腫 / 終末期 / G protein / Receptor / Molecular Medianism / G protein disease / Gene therapy / 脱感作 / 心肥大 / インバースアゴニスト / G PROTEIN / RECEPTOR / MOLECULAR MECHANISM / G PROTEIN DISEASE / GENE THERAPY / DESENSITIZATION / CARDIOMEGALY / INVERSE AGONIST / 同種造血幹細胞移植 / 移植片対宿主病 / トランスジェニックマウス / MHC class IIプロモーター / コンディショナルノックアウト / 自然免疫 / シランスジェニックマウス / Notchシグナル / 造血幹細胞 / 免疫調節 / GVHD / T細胞 / コンディショナルノックアウトマウス / allogeneic hematopoietic stem cell transplantation / graft-versus-host disease / transgenic mouse / MHC class II promoter / conditional knockout mouse / innate immunity Less
  • Research Projects

    (19 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (22 People)
  •  Study on r-and K-selection in hematological malignanciesPrincipal Investigator

    • Principal Investigator
      MOTOKURA Toru
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tottori University
      The University of Tokyo
  •  造血器悪性腫瘍患者・家族の終末期の実態把握と具体的支援の検討

    • Principal Investigator
      河 正子
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Clinical nursing
    • Research Institution
      The University of Tokyo
  •  Analysis of a role of r-and K-selection during malignant progression and K-induced multidrug resistancePrincipal Investigator

    • Principal Investigator
      MOTOKURA Toru
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  G PROTEIN AND DISEASES : ANALYSES OF MOLECULAR MECHANISMS AND REGULATION OF SIGNALS

    • Principal Investigator
      IIRI Taroh
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Endocrinology
    • Research Institution
      The UNIVERSITY OF TOKYO
  •  Assessment of immune modulation by Notch signaling-exploration of immunomodulatory intervention targeting Notch system.

    • Principal Investigator
      CHIBA Shigeru
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  Significance of r-and K-selection in hematological malignanciesPrincipal Investigator

    • Principal Investigator
      MOTOKURA Toru
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      THE UNIVERSITY OF TOKYO
  •  G protein diseases : analysis and application

    • Principal Investigator
      IIRI Taroh
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Endocrinology
    • Research Institution
      The University of Tokyo
  •  Analysis of cell-cycle regulation in hematopoietic cellsPrincipal Investigator

    • Principal Investigator
      MOTOKURA Toru
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      UNIVERSITY OF TOKYO
  •  Analysis of cell-cycle regulatory mechanisms in human hematopoietic cellsPrincipal Investigator

    • Principal Investigator
      MOTOKURA Toru
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  血液系腫瘍細胞におけるPRAD1/サイクリンD1の異常発現とその作用Principal Investigator

    • Principal Investigator
      本倉 徹
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  造血細胞の分化・増殖における細胞周期制御因子の発現様式の解析Principal Investigator

    • Principal Investigator
      本倉 徹
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  細胞の腫瘍化に伴うホルモン遺伝子活性化のメカニズム

    • Principal Investigator
      池田 恭治
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  血液系腫瘍細胞におけるPRAD1/サイクリンD1の異常発現とその作用Principal Investigator

    • Principal Investigator
      本倉 徹
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  血液系腫瘍細胞における癌遺伝子D型サイクリンファミリーの発現 様式の解析Principal Investigator

    • Principal Investigator
      本倉 徹
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  造血細胞の増殖・分化における細胞周期制御因子サイクリンの発現Principal Investigator

    • Principal Investigator
      本倉 徹
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  造血組織におけるアクチビンの作用機構の解明

    • Principal Investigator
      内丸 薫
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  血液系腫瘍細胞における癌遺伝子D型サイクリンファミリーの発現様式の解析Principal Investigator

    • Principal Investigator
      本倉 徹
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  アクチビンAによる白血病細胞の分化誘導機構

    • Principal Investigator
      山下 孝之
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  Hypercalcemic Factors in ATLPrincipal Investigator

    • Principal Investigator
      MOTOKURA Toru
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo

All 2007 2006

All Journal Article Presentation

  • [Journal Article] Aberrant overexpression of an epithelial marker, 14-3-3σ, in a subset of hematological malignancies2007

    • Author(s)
      Motokura T, et. al.
    • Journal Title

      BMC Cancer 7

      Pages: 217-217

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591042
  • [Journal Article] Aberrant overexpression of an epithelial marker, 14-3-3a, in a subset of hematological malignancies2007

    • Author(s)
      Motokura, T., Nakamura, Y., Hiroyuki, Sato
    • Journal Title

      BMC Cancer 7

      Pages: 217-217

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591042
  • [Journal Article] Aberrant overexpression of an epithelial marker, 14-3-3σ, in a subset of hematological malignancies2007

    • Author(s)
      Toru Motokura, et. al.
    • Journal Title

      BMC Cancer 7

      Pages: 217-217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591042
  • [Journal Article] Differential 14-3-3a DNA methylation and expression in c-myc and activated H-ras-transformed cells under r and K-selection2006

    • Author(s)
      Sato, H., Nakamura, Y., Motokura, T
    • Journal Title

      Cancer Lett 236

      Pages: 105-114

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591042
  • [Journal Article] Development of multidrug resistance due to multiple factors includingP-glycoprotein overexpression under K-selection after MYCand HRASoncogene activation2006

    • Author(s)
      Nakamura, Y., Sato, H., Motokura, T
    • Journal Title

      Int. J. Cancer 118(10)

      Pages: 2448-2454

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591042
  • [Journal Article] 造血器腫瘍における14-3-3σ遺伝子の発現解析2006

    • Author(s)
      本倉 徹 他
    • Journal Title

      臨床血液 47・9

      Pages: 264-264

    • Data Source
      KAKENHI-PROJECT-18591042
  • [Presentation] Analysis of 14-3-3a expression in hematological malignancies2006

    • Author(s)
      Motokura, T., Sato, H
    • Organizer
      The United General Meeting of the Japanese Society of Hematology and the Japanese Scoiety of Clinical Hematology
    • Place of Presentation
      Fukuoka
    • Year and Date
      2006-10-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591042
  • [Presentation] 造血器腫瘍における14-3-3σ遺伝子の発現解析2006

    • Author(s)
      本倉 徹、佐藤博之
    • Organizer
      第68回日本血液学会・第48回日本臨床血液学会合同総会
    • Place of Presentation
      福岡
    • Year and Date
      2006-10-06
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591042
  • 1.  内丸 薫 (60251203)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  NAKAHARA Tatsutoshi (20110744)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  IIRI Taroh (90313022)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  OHNISHI Hirohide (00313023)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  FUJITA Toshiro (10114125)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  MAKITA Noriko (60353455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  CHIBA Shigeru (60212049)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  OGAWA Seishi (60292900)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KANDA Yoshinobu (30334379)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  SUZUKI Takahiro (40345210)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  IGARASHI Tetsuya (00134601)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  MATSUMOTO Toshio (20157374)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  WATANABE Toshiki (30182934)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  山下 孝之 (10166671)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  池田 恭治 (00222878)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  尾形 悦郎 (70013761)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  河 正子 (60291316)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  宮下 光令 (90301142)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  高橋 強志 (70332608)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  KUMANO Keiki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  TAKAHASHI Shunji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  芝井 博四郎
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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