OHISHI Hirofumi 大石宏文

… Alternative Names

大石宏文オオイシヒロフミ

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Researcher Number	00211095
Other IDs
Affiliation (Current)	2023: 京都大学, 薬学研究科, 研究員
Affiliation (based on the past Project Information) *help	2002 – 2005: Osaka University of Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Lecturer, 薬学部, 講師 1997 – 2001: 大阪薬科大学, 薬学部, 助手 1999 – 2000: 大阪薬科大学, 情報科学解析センター, 助手 1993 – 1994: 大阪薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Physical pharmacy / Physical pharmacy Except Principal Investigator Chemical pharmacy
Keywords	Principal Investigator ポリアミン / 左巻きZ-DNA / minor groove / Z-DNA / Polyamine / B-Z転移 / 構造活性相関 / X線結晶構造解析 / 核酸 / X-線結晶構造解析 … More / 相互作用様式 / 分子設計 / 発癌機構 / X-ray crystallography / Molecular Dynamics / B-Z転移機構 / マイナーグルーブ / B-Z混合型DNA / B-Z junction / スペルミン / スペルミジン / インターカレーター / コンピューターシュミレーション / x線結晶構造解析 / コンピュータシュミレーション / 酵素 / 立体構造予測 / 分子動力学 / 塩濃度 / 安定化機構 / コンピューター解析 / 金属カウンターイオン / 構造科学 / 遺伝子発現制御機構 / left handed Z-DNA / salt concentration / interaction / molecular design / 長鎖左巻きDNA / 分子動力学計算 / 長鎖Z-DNA / 超伝導体 / ポリアミンナノワイヤー / スーパーコイル / X-ray crystallographic structure analysis / Interaction style / Molecule design / B-Z transition mechanism / Left-handed Z-DNA / long chain left-handed DNA / グルーブバインダー / マイナーグルーブキャビテ / DNA / モノアミン / コンフォメーション / 左巻きDNA / Z-型DNA / ポリアミンナノワイアー / 相互作用 / 結晶構造解析 / 三重螺旋 / 転写 / 高塩濃度 / スーパコイル / B-Z transfer / groove binder / B-Z combination crystal / minor groove cavity … More Except Principal Investigator 配列選択性 / DNA配列認識 / 新規リガンド / ビステトラヒドロフラン / ビスフラン / ビスピロール / DNA結合 / COMBINATORIAL CHEMISTRY / SOLID-STATE LIBRARY / PEPTIDE LIBRARY / DUPLEX DNA / DNA-BINDING MOLECULES / HYDROPHOBIC AMINO ACIDS Less

A structure scientific study about interaction of polyamine and left-handed DNA.Principal Investigator
- Principal Investigator
  
  OHISHI Hirofumi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Molecular Dynamics Calculation and X-ray Crystallographic Study of Interaction mode between Plyamine and Z-DNAPrincipal Investigator
- Principal Investigator
  
  OHISHI Hirofumi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Development of the New Recognition Molecules of DNA Sequences Based on the GC- and AT-Selective Ligands
- Principal Investigator
  
  SASAKI Shigeki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYUSHU UNIVERSITY
The Structural Studies of Interaction between Polyamine and Z-DNAPrincipal Investigator
- Principal Investigator
  
  OHISHI Hirofumi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
DNAと薬物の相互作用に関するX線構造化学、および構造活性相関研究Principal Investigator
- Principal Investigator
  
  大石宏文
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
DNAと薬物の相互作用に関するx線構造化学、および構造活性相関研究Principal Investigator
- Principal Investigator
  
  大石宏文
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences

All 2006 2005 2004

All Journal Article

[Journal Article] Synthesis and properties of 2'-O,4'-C-methylene-oxy-methylene bridged nucleic acid.2006
- Author(s)
  Hari, Yoshiyuki, Obika, Satoshi, Ohnishi, Ryo, Eguchi, Ken, Osaki, Tomohisa, Ohishi, Hirofumi, Imanishi, Takeshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry 14
  
  Pages: 1029-1038
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590051
[Journal Article] 計算機科学を用いたDNAの創薬化学2006
- Author(s)
  大石宏文
- Journal Title
  
  生産と技術 (印刷中)
- NAID
  40007273215
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590051
[Journal Article] Intermolecular association model of antifungal polyene macrolide via concerted =C-H... O interaction : X-ray crystal structure analysis and ab initio molecular-orbital calculations of chainin.2006
- Author(s)
  In, Yasuko, Ohishi, Hirofumi, Miyagawa, Hiroo, Kitamura, Kunihiro, Igarashi, Yasuhiro, Ishida, Toshimasa.
- Journal Title
  
  Bulletin of the Chemical Society of Japan 79
  
  Pages: 126-133
- NAID
  10017170346
- Data Source
  KAKENHI-PROJECT-15590051
[Journal Article] Synthesis and properties of 2'-0,4'-C-methylene-oxy-methylene bridged nucleic acid.2006
- Author(s)
  Hari, Yoshiyuki, Obika, Satoshi, Ohnishi, Ryo, Eguchi, Ken, Osaki, Tomohisa, Ohishi, Hirofumi, Imanishi, Takeshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry 14
  
  Pages: 1029-1038
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590051
[Journal Article] Antineoplastic Agents. 551. Isolation and Structures of Bauhiniastatins 1-4 from Bauhinia purpurea.2006
- Author(s)
  Pettit, George R., Numata, Atsushi, Iwamoto, Chika, Usami, Yoshihide, Yamada, Takeshi, Ohishi, Hirofumi, Cragg, Gordon M.
- Journal Title
  
  Journal of Natural Products 69
  
  Pages: 323-327
- Data Source
  KAKENHI-PROJECT-15590051
[Journal Article] Intermolecular association model of antifungal polyene macrolide via concerted =C-H… O interactions : X-ray crystal structure analysis and ab initio molecular-orbital calculations of chainin.2006
- Author(s)
  In, Yasuko, Ohishi, Hirofumi, Miyagawa, Hiroo, Kitamura, Kunihiro, Igarashi, Yasuhiro, Ishida, Toshimasa.
- Journal Title
  
  Bulletin of the Chemical Society of Japan 79
  
  Pages: 126-133
- NAID
  10017170346
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590051
[Journal Article] Antineoplastic Agents. 551. Isolation and Structures of Bauhiniastatins 1-4 from Bauhinia purpurea.2006
- Author(s)
  Pettit, George R., Numata, Atsushi, Iwamoto, Chika, Usami, Yoshihide, Yamada, Takeshi, Ohishi, Hirofumi, Cragg, Gordon M
- Journal Title
  
  Journal of Natural Products 69
  
  Pages: 323-327
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590051
[Journal Article] Synthesis and properties of 2'-O,4'-C-methylene-oxy-methylene bridged nucleic acid.2006
- Author(s)
  Hari, Yoshiyuki, Obika, Satoshi, Ohnishi, Ryo, Eguchi, Ken, Osaki, Tomohisa, Ohishi, Hirofumi, Imanishi, Takeshi.
- Journal Title
  
  Bioorganic & Medicinal Chemistry 14
  
  Pages: 1029-1038
- Data Source
  KAKENHI-PROJECT-15590051
[Journal Article] 計算機科学を用いたDNAの創薬化学2006
- Author(s)
  大石宏文
- Journal Title
  
  生産と技術印刷中
- NAID
  40007273215
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590051
[Journal Article] The development of crystallization and X-ray crystallography method of long stem DNA2005
- Author(s)
  Hirofumi Ohishi, Koji Tsukamoto, Mamiko Odoko, Kazimierz Rzeskowiak, Naoyoshi Maezaki, Nobuo Okabe, Tetsuaki Tanaka, Toshimasa Ishida
- Journal Title
  
  Nucleic Acids Research Supplement
  
  Pages: 67-68
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590051
[Journal Article] Stabilization of the left-handed Z-DNA with monoamines and polyamines2005
- Author(s)
  Koji Tsukamoto, Mamiko Odoko, Hirofumi Ohishi, Yoichi Hiyama, Naoyoshi Maezaki, Nobuo Okabe, Tetsuaki Tanaka, Toshimasa Ishida
- Journal Title
  
  Nucleic Acids Research Supplement
  
  Pages: 251-252
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590051
[Journal Article] The development of crystallization and X-ray crystallographyh method of long stem DNA2005
- Author(s)
  Hirofumi Ohishi, Koji Tsukamoto, Mamiko Odoko, Kazimierz Grzeskowiak, Naoyoshi Maezaki, Nobuo Okabe, Tetsuaki Tanaka, Toshimasa Ishida
- Journal Title
  
  Nucleic Acids Research Supplement
  
  Pages: 67-68
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590051
[Journal Article] The X-ray crystallographic study of the conformation of Z-DNA which bound to polyamine for the minor groove at room temperature and low temperature2004
- Author(s)
  Hirofumi Ohishi, Toshimasa Ishida, Kenji Suzuki, Kazimierz Grzeskowiak, Mamiko Odoko, Nobuo Okabe
- Journal Title
  
  Nucleic Acids Research S2
  
  Pages: 256-257
- Data Source
  KAKENHI-PROJECT-15590051
[Journal Article] Berberine/γ-cyclodextrin inclusion structure studied by 1H-NMR spectroscopy and molecular-dynamics calculations.2004
- Author(s)
  Kamigauchi, Miyoko, Kanbara, Narumi, Sugiura, Makiko, Iwasa, Kinuko, Ohishi, Hirofumi, Ishida, Toshimasa.
- Journal Title
  
  Helvetica Chimica Acta 87
  
  Pages: 264-271
- Data Source
  KAKENHI-PROJECT-15590051
[Journal Article] Asymmetric Intramolecular Michael Addition of α-Sulfinyl Vinylic Carbanion to Enoates.2004
- Author(s)
  Maezaki, Naoyoshi, Sawamoto, Hiroaki, Yuyama, Sachiko, Yoshigami, Ryoko, Suzuki, Tomoko, Izumi, Mayuko, Ohishi, Hirofumi, Tanaka, Tetsuaki.
- Journal Title
  
  Journal of Organic Chemistry 69
  
  Pages: 6335-6340
- Data Source
  KAKENHI-PROJECT-15590051

1. SASAKI Shigeki (10170672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. NAGATSUGI Fumi (90208025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TORIGOE Hidetaka (80227678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OHISHI Hirofumi 大石 宏文

大石 宏文 オオイシ ヒロフミ

Research Projects

Research Products

Co-Researchers

A structure scientific study about interaction of polyamine and left-handed DNA.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Dynamics Calculation and X-ray Crystallographic Study of Interaction mode between Plyamine and Z-DNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the New Recognition Molecules of DNA Sequences Based on the GC- and AT-Selective Ligands

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Structural Studies of Interaction between Polyamine and Z-DNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNAと薬物の相互作用に関するX線構造化学、および構造活性相関研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNAと薬物の相互作用に関するx線構造化学、および構造活性相関研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Synthesis and properties of 2'-O,4'-C-methylene-oxy-methylene bridged nucleic acid.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] 計算機科学を用いたDNAの創薬化学2006

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Intermolecular association model of antifungal polyene macrolide via concerted =C-H... O interaction : X-ray crystal structure analysis and ab initio molecular-orbital calculations of chainin.2006

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Synthesis and properties of 2'-0,4'-C-methylene-oxy-methylene bridged nucleic acid.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Antineoplastic Agents. 551. Isolation and Structures of Bauhiniastatins 1-4 from Bauhinia purpurea.2006

Author(s)

Journal Title

Data Source

[Journal Article] Intermolecular association model of antifungal polyene macrolide via concerted =C-H… O interactions : X-ray crystal structure analysis and ab initio molecular-orbital calculations of chainin.2006

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Antineoplastic Agents. 551. Isolation and Structures of Bauhiniastatins 1-4 from Bauhinia purpurea.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Synthesis and properties of 2'-O,4'-C-methylene-oxy-methylene bridged nucleic acid.2006

Author(s)

Journal Title

OHISHI Hirofumi 大石宏文

大石宏文オオイシヒロフミ