Tohru Ogihara 荻原享

… Alternative Names

OGIHARA Tohru 荻原享

荻原亨オギハラトオル

萩原亨ハギワラトオル

Less

Researcher Number	00211128
Affiliation (based on the past Project Information) *help	2021: 大阪医科薬科大学, 医学部, 准教授 2018 – 2020: 大阪医科大学, 医学部, 准教授 2016: 大阪医科大学, 医学部, 准教授 2010 – 2015: 大阪医科大学, 医学部, 講師 2004 – 2008: 大阪医科大学, 医学部, 講師 … More 1998 – 2000: 大阪医科大学, 医学部, 講師 1997: 大阪医科大学, 医学部, 構師 1991 – 1996: 大阪医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Embryonic/Neonatal medicine / Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator 新生児慢性肺疾患 / PC 12 / 新生児仮死 / フリーラジカル / LDL / アスコルビン酸 / 酸化ストレスマーカー / 早産低出生体重児 / ガスクロマトグラフィー質量分析 / 超微量定量 … More / ガスクロマトグラフィー質量解析 / 超早産児 / 脂肪酸組成 / 血中脂肪酸 / 早産低修正体重児 / 気管支肺異形成 / 血中脂肪酸分析 / Ascorbic acid / Iron / Hypoxic ischemic encephalopathy / Free radical / Hypothermia / 鉄 / 低酸素性虚血性脳症 / 脳低温療法 / Respiratory Distress Syndrome / Uric Acid / Allantoin / Lipid Peroxidation / Free Radical / Active Oxygen Species / Homocystinuria / ビタミンE / 酸化変性LDL / フリ-ラジカル / デヒドロアスコルビン酸 / 酸化LDL / ホモシスチン尿症 / RDS / 呼吸窮迫症候群 / 活性酸素 / 脂質過酸化 / アラントイン / lipoxin / 炎症収束性脂質メディエーター / Bleomycin肺線維症モデル / 炎症収束性メディエーター / bleomycin / resolvin / BPD / 酸化還元電立 / 尿酸 / 酸化還元電位 / レドックス / グルタチオン / ortho-Tyrosine / HODE / dityrosine / 酸素毒性 / oxygen radical / newborn / uric acid / allntoin / chronic lung disease … More Except Principal Investigator Ca / サイトカイン / β-カロチン / 新生児ラット / 早産児肺障害 / 虚血再灌流肺障害 / 水素ガス / 新生仔豚 / neurological sequelae / central nervous system infection / cerebrospinal fluid / nitric oxide / biopterin / neopterin / 一酸化窒素NO / 小児 / 後遺症 / 一酸化窒素 / ビオプテリン / ネオプテリン / 髄液 / 中枢神経感染症 / nucleotide excision repair / DNA / Xeroderma pigmentosum / DNA診断 / RNA解析 / XPAC蛋白 / 活性酸素消去酵素 / DNA修復 / DNA結合能 / フィルターバインデイングアッセ- / E-cluster region / yeast two-hybrid system / ERCC1蛋白質 / XPA蛋白質 / DNA修復蛋白質 / A群色素性乾皮症 / ヌクレオチド除去修復機構 / XPA / 色素性乾皮症 / short-circuit current / Monochloramine / GSH / ラット腸上皮 / NH_2Cl / 腸粘膜 / NH_2cl / イオン分泌 / cytokine / alpha-tocopherol / free-radical / vasculitis / collagen disease of childhood / リンパ球幼若化反応 / α-tocopherol / フリーラジカル / 血管炎 / 小児膠原病 / 未熟児 / CD8比 / CD4 / T細胞 / 免疫 / 母乳 / レチノール / ビタミン-A / 慢性肺疾患 / 末熟児 Less

The new therapy for preterm lung injury using hydrogen gas
- Principal Investigator
  
  近藤園子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kagawa University
Relationship between changes over time in plasma fatty acid composition in very preterm infants and the development of bronchopulmonary dysplasia using a novel ultra-trace quantification method.Principal Investigator
- Principal Investigator
  
  Tohru Ogihara
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Osaka Medical and Pharmaceutical University
A pro-resolving lipid mediator effectively restores bleomycin-induced alveolar maturation arrest in neonatal ratsPrincipal Investigator
- Principal Investigator
  
  Ogihara Tohru
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Osaka Medical College
The redox environment surrounding lung epithelia is collapsed in the infants exposed antenatally to placental infection with subsequent bronchopulmonary dysplasiaPrincipal Investigator
- Principal Investigator
  
  OGIHARA Tohru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Osaka Medical College
The assessment of oxygen toxicity in early postnatal life and its relationship with gestational age in preterm infantsPrincipal Investigator
- Principal Investigator
  
  OGIHARA Tohru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Osaka Medical College
Moderate hypothermia inhibits the death of differentiated PC12 cells mediated by simultaneous exposure to iron and ascorbic acidPrincipal Investigator
- Principal Investigator
  
  OGIHARA Toru
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Osaka Medical College
Clinical and Immunological Study on Pediatric Central Nervous System Infectious Diseases For Understanding of Neuronal Damage Mechanism
- Principal Investigator
  
  SUZUKI Shuhei
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka Medical College
Clinical symptoms and molecular basis of group A xeroderma pigmentosum
- Principal Investigator
  
  TAMAI Hiroshi, 川村尚久
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka Medical College
母乳中β-カロチンの栄養学的意義に関する研究
- Principal Investigator
  
  MINO Makoto
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka Medical College
新生児慢性肺疾患の発症における活性酸素の関与についてPrincipal Investigator
- Principal Investigator
  
  荻原享
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka Medical College
Investigation of free-radical participation in collagen disease and vasculitis syndrome in childhood
- Principal Investigator
  
  KITAGAWA Makoto
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka Medical College
Study of Intracellular Mechanism of Intestinal Ion Secretion Induced by Active Oxygen
- Principal Investigator
  
  TAMAI Hiroshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  OSAKA MEDICAL COLLEGE
レチノイド,B-カロチンの新生児における栄養評価とその臨床応用
- Principal Investigator
  
  岡本良三
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka Medical College
Possible involvement of active oxygen species on the patients with homocystinuria and the infants with respiratory distress syndromePrincipal Investigator
- Principal Investigator
  
  OGIHARA Tohru
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka Medical College

All 2016 2012 2011 2010 2009 2007 2006 2005 Other

All Journal Article Presentation Book

[Book] 今〓日の〓小児治療指針第15 版2012
- Author(s)
  荻原享新生児慢性肺疾患
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-22591211
[Journal Article] Antenatal exposure to Ureaplasma species exacerbates bronchopulmonary dysplasia synergistically with subsequent prolonged mechanical ventilation in preterm infants2012
- Author(s)
  Inatomi T, Oue S, Ogihara T, Hira S, Hasegawa M, Yamaoka S, Yasui M, Tamai H
- Journal Title
  
  Pediatric Research
  
  Volume: 71 Issue: 3 Pages: 267-273
- DOI
  10.1038/pr.2011.47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591211
[Journal Article] Antenatal exposure to Ureaplasma species exacerbates bronchopulmonary dysplasia synergistically with subsequent prolonged mechanical ventilation in preterm infants.2012
- Author(s)
  Inatomi T, Oue S, Ogihara T, Hira S, Hasegawa M, Yamaoka S, Yasui M, Tamai H.
- Journal Title
  
  Pediatr Res.
  
  Volume: 71 Pages: 267-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591211
[Journal Article] Meconium aspiration2011
- Author(s)
  Ban R, Ogihara T, Mori Y, Oue S, Ogawa S, Tamai H.
- Journal Title
  
  Neonatology.
  
  Volume: 99 Pages: 272-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591211
[Journal Article] Neonatal streptococcal toxic shock syndrome caused by Streptococcus dysgalactiae subsp. equisimilis.2010
- Author(s)
  Yamaoka S, Ogihara T, Yasui M, Hasegawa M, Hira S, Oue S, Ubukata K, Watanabe H, Takahashi T
- Journal Title
  
  Pediatr Infect Dis J.
  
  Volume: 29 Pages: 979-981
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591211
[Journal Article] カルボニル化蛋白2010
- Author(s)
  荻原享
- Journal Title
  
  日本臨床68広範囲血液・尿化学検査
  
  Pages: 843-8
- Data Source
  KAKENHI-PROJECT-22591211
[Journal Article] カルボニル化タンパク2010
- Author(s)
  荻原享
- Journal Title
  
  日本臨床
  
  Volume: 68 Pages: 843-848
- Data Source
  KAKENHI-PROJECT-22591211
[Journal Article] Meconium Aspiration Delays Normal Decline of Pulmonary Vascular Resistance Shortly after Birth through Lung Parenchymal Injury.2010
- Author(s)
  Ban R, Ogihara T, Mori Y, Oue S, Ogawa S, Tamai H
- Journal Title
  
  Neonatology
  
  Volume: 99 Pages: 272-279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591211
[Journal Article] Hypothermic inhibition of apoptotic pathways for combined neurotoxicity of iron and ascorbic acid in differentiated PC12 cells : reduction of oxidative stress and maintenance of the glutathione redox state2009
- Author(s)
  Masashi Hasegawa, Tohru Ogihara, Hiroshi Tamai, and Mayo Hiroi
- Journal Title
  
  Brain Research (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591289
[Journal Article] Antenatal primingによるCLDの重症化2009
- Author(s)
  荻原享、大植慎也
- Journal Title
  
  周産期医学 39
  
  Pages: 750-760
- Data Source
  KAKENHI-PROJECT-19591289
[Journal Article] Hypothermic inhibition of apoptotic pathways for combined neurotoxiicity of iron and ascorbic acid in differentiated PC12 cells : reduction of oxidative stress and maintenance of the glutathione redx state2009
- Author(s)
  Masashi Hasegawa, Tohru Ogihara, Hiroshi Tamai, Mayo Hiroi
- Journal Title
  
  Brain research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591289
[Journal Article] Moderate hypothermia inhibits the death of differentiated PC12 cells mediated by simultaneous exposure to iron and ascorbic acid.2007
- Author(s)
  Hasegawa M, Ogihara T, Hiroi M, Tamai H
- Journal Title
  
  J Neurochem (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591082
[Journal Article] Plasma KL-6 predicts the development and outcome of bronchopulmonary dysplasia2006
- Author(s)
  Tohru Ogihara, Kazuya Hirano, Takao Morinobu, Han-Suk Kim, Satoru Ogawa, Mayo Hiroi, Shinya Oue, Ryoichi Ban, Seigo Hira, Masashi Hasegawa, Shigeo Yamaoka, Masako Yasui
- Journal Title
  
  Pediatric research 60
  
  Pages: 613-618
- Data Source
  KAKENHI-PROJECT-16591082
[Journal Article] Plasma KL-6 predicts the development and outcome of bronchopulmonary dysplasia2006
- Author(s)
  Tohru Ogihara, Kazuya Hirano, Takao Morinobu, Han-Suk Kim, Satoru Ogawa, Mayo Hiroi, Shinya Oue, Ryoichi Ban, Seigo Hira, Masashi Hasegawa, Shigeo Yamaoka, Masako Yasui
- Journal Title
  
  Pediatric research (In press)
- Data Source
  KAKENHI-PROJECT-16591082
[Journal Article] Plasma KL-6 predicts the development and outcome of bronchopulmonary dysplasia2006
- Author(s)
  Tohru Ogihara, Kazuya Hirano, Takao Morinobu, Han-Suk Kim, Satoru Ogawa, Mayo Hiroi, Shinya Oue, Ryoichi Ban, Seigo Hira, Masashi Hasegawa, Shigeo Yamaoka, Masako Yasui
- Journal Title
  
  Pediatric Research 60
  
  Pages: 613-618
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591082
[Journal Article] Plasma KL-6 predicts the development and outcome of bronchopulmonary dysplasia2006
- Author(s)
  Tohru Ogihara, Kazuya Hirano, Takao Morinobu, Han-Suk Kim, Satoru Ogawa, Mayo Hiroi, Shinya Oue, Ryoichi Ban, Seigo Hira, Masashi Hasegawa, Shigeo Yamaoka, Masako Yasui
- Journal Title
  
  Pediat Res. 60
  
  Pages: 613-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591082
[Journal Article] Regulation of apoptosis by glutathione redox state in PC12 Cells exposed simultaneously to iron and ascorbic acid2005
- Author(s)
  Mayo Hiroi, Tohru Ogihara, Kazuya Hirano, Masashi Hasegawa, Takao Morinobu, Hiroshi Tamai, Etsuo Niki
- Journal Title
  
  Free Radical Biology and Medicine 38
  
  Pages: 1057-1072
- Data Source
  KAKENHI-PROJECT-16591082
[Journal Article] Regulation of apoptosis by glutathione redox state in PC12 cells exposed simultaneously to iron and ascorbic acid.2005
- Author(s)
  Hiroi M, Ogihara T, Hirano K, Hasegawa M, Morinobu T, Tamai H, Niki E
- Journal Title
  
  Free Radical Biology and Medicine 38
  
  Pages: 1057-1072
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591082
[Journal Article] Venepuncture is preferable to heel lance for blood sampling in term neonates2005
- Author(s)
  Satoru Ogawa, Tohru Ogihara, Emi Fujiwara, Kazumi Ito, Mutsumi Nakano, Satsuki Nakayama, Tomomi Hachiya, Naomi Fujimoto, Hiroko Abe, Satoko Ban, Etsuko Ikeda, Hiroshi Tamai
- Journal Title
  
  Archives of Disease in Childhood Fetal Neonatal Edition (In press)
- Data Source
  KAKENHI-PROJECT-16591082
[Journal Article] Regulation of apoptosis by glutathione redox state in PC12 cells exposed simultaneously to iron and ascorbic acid.2005
- Author(s)
  Hiroi M, Ogihara T, Hirano K, Hasegawa M, Morinobu T, Tamai H, Niki E.
- Journal Title
  
  Free Radic Biol Med. 38
  
  Pages: 1057-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591082
[Journal Article] Moderate hypothermia inhibits the death of differentiated PC12 cells mediated by simultaneous exposure to iron and ascorbic acid.
- Author(s)
  Hasegawa M, Ogihara T, Hiroi M, Tamai H.
- Journal Title
  
  J Neurochem (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591082
[Presentation] Bleomycin誘発BPDモデルに対する抗炎症性脂質メディエーターの有効性について2016
- Author(s)
  篠原潤、桝田翠、山岡繁夫、長谷川昌史、荻原享
- Organizer
  日本新生児成育医学会
- Place of Presentation
  大阪国際会議場(大阪府大阪市)
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-25461657
[Presentation] 炎症性疾患としての CLD ー視点を変えれば、新たな可能性が?見?えてくる2011
- Author(s)
  荻原享
- Organizer
  日本未熟児新生児学会
- Place of Presentation
  東京
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-22591211
[Presentation] 新生児にとって酸素はそんなに危険なのだろうか2007
- Author(s)
  荻原享
- Organizer
  第52回日本未熟児新生児学会
- Place of Presentation
  香川
- Year and Date
  2007-11-26
- Data Source
  KAKENHI-PROJECT-19591289
[Presentation] Non-resolving inflammationとしてのCLD～新たな視点から、次世代の予防・治療法を考える～
- Author(s)
  荻原　享
- Organizer
  近畿新生児研究会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-22591211

1. TAMAI Hiroshi (30179874)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
2. MINO Makoto (70090206)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. KITAGAWA Makoto (70175298)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 岡本良三 (80131324)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. YOSHIDA Yasukazu (90358333)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KAWAMURA N (50247863)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SUZUKI Shuhei (10278525)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 山岡繁夫 (90434779)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. OUE Shinya (40399085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. YASUDA Hiroshi (10220154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 長谷川昌史 (80388264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 安井昌子 (70550218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 近藤園子 (70437680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 安田真之 (00380155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中村信嗣 (30437686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 日下隆 (50274288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 真砂光宏

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 永井章

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Tohru Ogihara 荻原 享

OGIHARA Tohru 荻原 享

荻原 亨 オギハラ トオル

萩原 亨 ハギワラ トオル

Research Projects

Research Products

Co-Researchers

The new therapy for preterm lung injury using hydrogen gas

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Relationship between changes over time in plasma fatty acid composition in very preterm infants and the development of bronchopulmonary dysplasia using a novel ultra-trace quantification method.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A pro-resolving lipid mediator effectively restores bleomycin-induced alveolar maturation arrest in neonatal ratsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The redox environment surrounding lung epithelia is collapsed in the infants exposed antenatally to placental infection with subsequent bronchopulmonary dysplasiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The assessment of oxygen toxicity in early postnatal life and its relationship with gestational age in preterm infantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Moderate hypothermia inhibits the death of differentiated PC12 cells mediated by simultaneous exposure to iron and ascorbic acidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical and Immunological Study on Pediatric Central Nervous System Infectious Diseases For Understanding of Neuronal Damage Mechanism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical symptoms and molecular basis of group A xeroderma pigmentosum

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

母乳中β-カロチンの栄養学的意義に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新生児慢性肺疾患の発症における活性酸素の関与についてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of free-radical participation in collagen disease and vasculitis syndrome in childhood

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of Intracellular Mechanism of Intestinal Ion Secretion Induced by Active Oxygen

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

レチノイド,B-カロチンの新生児における栄養評価とその臨床応用

Tohru Ogihara 荻原享

OGIHARA Tohru 荻原享

荻原亨オギハラトオル

萩原亨ハギワラトオル

[Book] 今〓日の〓小児治療指針第15 版2012