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Ogihara Tohru  荻原 享

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… Alternative Names

荻原 享  オギハラ トオル

OGIHARA Tohru  荻原 享

荻原 亨  オギハラ トオル

萩原 亨  ハギワラ トオル

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Researcher Number 00211128
Affiliation (Current) 2022: 大阪医科薬科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2018 – 2020: 大阪医科大学, 医学部, 准教授
2016: 大阪医科大学, 医学部, 准教授
2010 – 2015: 大阪医科大学, 医学部, 講師
2004 – 2008: 大阪医科大学, 医学部, 講師
1998 – 2000: 大阪医科大学, 医学部, 講師
1997: 大阪医科大学, 医学部, 構師
1991 – 1996: 大阪医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Embryonic/Neonatal medicine / Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Except Principal Investigator
Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords
Principal Investigator
新生児慢性肺疾患 / 早産低出生体重児 / 酸化ストレスマーカー / アスコルビン酸 / LDL / フリーラジカル / 新生児仮死 / PC 12 / chronic lung disease / allntoin … More / uric acid / newborn / oxygen radical / 酸素毒性 / dityrosine / HODE / ortho-Tyrosine / グルタチオン / レドックス / 酸化還元電位 / 尿酸 / 酸化還元電立 / BPD / resolvin / bleomycin / 炎症収束性メディエーター / Bleomycin肺線維症モデル / 炎症収束性脂質メディエーター / lipoxin / アラントイン / 脂質過酸化 / 活性酸素 / 呼吸窮迫症候群 / RDS / ホモシスチン尿症 / 酸化LDL / デヒドロアスコルビン酸 / フリ-ラジカル / 酸化変性LDL / ビタミンE / Homocystinuria / Active Oxygen Species / Free Radical / Lipid Peroxidation / Allantoin / Uric Acid / Respiratory Distress Syndrome / 脳低温療法 / 低酸素性虚血性脳症 / 鉄 / Hypothermia / Free radical / Hypoxic ischemic encephalopathy / Iron / Ascorbic acid / 血中脂肪酸 / 脂肪酸組成 / 超早産児 / ガスクロマトグラフィー質量解析 / 超微量定量 / ガスクロマトグラフィー質量分析 … More
Except Principal Investigator
β-カロチン / サイトカイン / Ca / 末熟児 / 慢性肺疾患 / ビタミン-A / レチノール / 母乳 / 免疫 / T細胞 / CD4 / CD8比 / 未熟児 / 小児膠原病 / 血管炎 / フリーラジカル / α-tocopherol / リンパ球幼若化反応 / collagen disease of childhood / vasculitis / free-radical / alpha-tocopherol / cytokine / イオン分泌 / NH_2cl / 腸粘膜 / NH_2Cl / ラット腸上皮 / GSH / Monochloramine / short-circuit current / 色素性乾皮症 / XPA / ヌクレオチド除去修復機構 / A群色素性乾皮症 / DNA修復蛋白質 / XPA蛋白質 / ERCC1蛋白質 / yeast two-hybrid system / E-cluster region / フィルターバインデイング アッセ- / DNA結合能 / DNA修復 / 活性酸素消去酵素 / XPAC蛋白 / RNA解析 / DNA診断 / Xeroderma pigmentosum / DNA / nucleotide excision repair / 中枢神経感染症 / 髄液 / ネオプテリン / ビオプテリン / 一酸化窒素 / 後遺症 / 小児 / 一酸化窒素NO / neopterin / biopterin / nitric oxide / cerebrospinal fluid / central nervous system infection / neurological sequelae / 早産児肺障害 / 水素ガス / 新生児ラット Less
  • Research Projects

    (14 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (18 People)
  •  The new therapy for preterm lung injury using hydrogen gas

    • Principal Investigator
      近藤 園子
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Kagawa University
  •  新規超微量定量法を用いた超早産児血漿中脂肪酸組成の経時的変化と慢性肺疾患の関係Principal Investigator

    • Principal Investigator
      荻原 享
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Osaka Medical College
  •  A pro-resolving lipid mediator effectively restores bleomycin-induced alveolar maturation arrest in neonatal ratsPrincipal Investigator

    • Principal Investigator
      Ogihara Tohru
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Embryonic/Neonatal medicine
    • Research Institution
      Osaka Medical College
  •  The redox environment surrounding lung epithelia is collapsed in the infants exposed antenatally to placental infection with subsequent bronchopulmonary dysplasiaPrincipal Investigator

    • Principal Investigator
      OGIHARA Tohru
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Embryonic/Neonatal medicine
    • Research Institution
      Osaka Medical College
  •  The assessment of oxygen toxicity in early postnatal life and its relationship with gestational age in preterm infantsPrincipal Investigator

    • Principal Investigator
      OGIHARA Tohru
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Embryonic/Neonatal medicine
    • Research Institution
      Osaka Medical College
  •  Moderate hypothermia inhibits the death of differentiated PC12 cells mediated by simultaneous exposure to iron and ascorbic acidPrincipal Investigator

    • Principal Investigator
      OGIHARA Toru
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Embryonic/Neonatal medicine
    • Research Institution
      Osaka Medical College
  •  Clinical and Immunological Study on Pediatric Central Nervous System Infectious Diseases For Understanding of Neuronal Damage Mechanism

    • Principal Investigator
      SUZUKI Shuhei
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Osaka Medical College
  •  Clinical symptoms and molecular basis of group A xeroderma pigmentosum

    • Principal Investigator
      TAMAI Hiroshi, 川村 尚久
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Osaka Medical College
  •  母乳中β-カロチンの栄養学的意義に関する研究

    • Principal Investigator
      MINO Makoto
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Osaka Medical College
  •  新生児慢性肺疾患の発症における活性酸素の関与についてPrincipal Investigator

    • Principal Investigator
      荻原 享
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Osaka Medical College
  •  Investigation of free-radical participation in collagen disease and vasculitis syndrome in childhood

    • Principal Investigator
      KITAGAWA Makoto
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Osaka Medical College
  •  Study of Intracellular Mechanism of Intestinal Ion Secretion Induced by Active Oxygen

    • Principal Investigator
      TAMAI Hiroshi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      OSAKA MEDICAL COLLEGE
  •  レチノイド,B-カロチンの新生児における栄養評価とその臨床応用

    • Principal Investigator
      岡本 良三
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Osaka Medical College
  •  Possible involvement of active oxygen species on the patients with homocystinuria and the infants with respiratory distress syndromePrincipal Investigator

    • Principal Investigator
      OGIHARA Tohru
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Osaka Medical College

All 2016 2012 2011 2010 2009 2007 2006 2005 Other

All Journal Article Presentation Book

  • [Book] 今〓日の〓小児治療指針 第15 版2012

    • Author(s)
      荻原享新生児慢性肺疾患
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-22591211
  • [Journal Article] Antenatal exposure to Ureaplasma species exacerbates bronchopulmonary dysplasia synergistically with subsequent prolonged mechanical ventilation in preterm infants2012

    • Author(s)
      Inatomi T, Oue S, Ogihara T, Hira S, Hasegawa M, Yamaoka S, Yasui M, Tamai H
    • Journal Title

      Pediatric Research

      Volume: 71 Pages: 267-273

    • DOI

      10.1038/pr.2011.47

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591211
  • [Journal Article] Antenatal exposure to Ureaplasma species exacerbates bronchopulmonary dysplasia synergistically with subsequent prolonged mechanical ventilation in preterm infants.2012

    • Author(s)
      Inatomi T, Oue S, Ogihara T, Hira S, Hasegawa M, Yamaoka S, Yasui M, Tamai H.
    • Journal Title

      Pediatr Res.

      Volume: 71 Pages: 267-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591211
  • [Journal Article] Meconium aspiration2011

    • Author(s)
      Ban R, Ogihara T, Mori Y, Oue S, Ogawa S, Tamai H.
    • Journal Title

      Neonatology.

      Volume: 99 Pages: 272-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591211
  • [Journal Article] Neonatal streptococcal toxic shock syndrome caused by Streptococcus dysgalactiae subsp. equisimilis.2010

    • Author(s)
      Yamaoka S, Ogihara T, Yasui M, Hasegawa M, Hira S, Oue S, Ubukata K, Watanabe H, Takahashi T
    • Journal Title

      Pediatr Infect Dis J.

      Volume: 29 Pages: 979-981

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591211
  • [Journal Article] カルボニル化蛋白2010

    • Author(s)
      荻原享
    • Journal Title

      日本臨床68広範囲血液・尿化学検査

      Pages: 843-8

    • Data Source
      KAKENHI-PROJECT-22591211
  • [Journal Article] カルボニル化タンパク2010

    • Author(s)
      荻原享
    • Journal Title

      日本臨床

      Volume: 68 Pages: 843-848

    • Data Source
      KAKENHI-PROJECT-22591211
  • [Journal Article] Meconium Aspiration Delays Normal Decline of Pulmonary Vascular Resistance Shortly after Birth through Lung Parenchymal Injury.2010

    • Author(s)
      Ban R, Ogihara T, Mori Y, Oue S, Ogawa S, Tamai H
    • Journal Title

      Neonatology

      Volume: 99 Pages: 272-279

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591211
  • [Journal Article] Hypothermic inhibition of apoptotic pathways for combined neurotoxicity of iron and ascorbic acid in differentiated PC12 cells : reduction of oxidative stress and maintenance of the glutathione redox state2009

    • Author(s)
      Masashi Hasegawa, Tohru Ogihara, Hiroshi Tamai, and Mayo Hiroi
    • Journal Title

      Brain Research (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591289
  • [Journal Article] Antenatal primingによるCLDの重症化2009

    • Author(s)
      荻原享、大植慎也
    • Journal Title

      周産期医学 39

      Pages: 750-760

    • Data Source
      KAKENHI-PROJECT-19591289
  • [Journal Article] Hypothermic inhibition of apoptotic pathways for combined neurotoxiicity of iron and ascorbic acid in differentiated PC12 cells : reduction of oxidative stress and maintenance of the glutathione redx state2009

    • Author(s)
      Masashi Hasegawa, Tohru Ogihara, Hiroshi Tamai, Mayo Hiroi
    • Journal Title

      Brain research (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591289
  • [Journal Article] Moderate hypothermia inhibits the death of differentiated PC12 cells mediated by simultaneous exposure to iron and ascorbic acid.2007

    • Author(s)
      Hasegawa M, Ogihara T, Hiroi M, Tamai H
    • Journal Title

      J Neurochem (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591082
  • [Journal Article] Plasma KL-6 predicts the development and outcome of bronchopulmonary dysplasia2006

    • Author(s)
      Tohru Ogihara, Kazuya Hirano, Takao Morinobu, Han-Suk Kim, Satoru Ogawa, Mayo Hiroi, Shinya Oue, Ryoichi Ban, Seigo Hira, Masashi Hasegawa, Shigeo Yamaoka, Masako Yasui
    • Journal Title

      Pediatric research 60

      Pages: 613-618

    • Data Source
      KAKENHI-PROJECT-16591082
  • [Journal Article] Plasma KL-6 predicts the development and outcome of bronchopulmonary dysplasia2006

    • Author(s)
      Tohru Ogihara, Kazuya Hirano, Takao Morinobu, Han-Suk Kim, Satoru Ogawa, Mayo Hiroi, Shinya Oue, Ryoichi Ban, Seigo Hira, Masashi Hasegawa, Shigeo Yamaoka, Masako Yasui
    • Journal Title

      Pediatric research (In press)

    • Data Source
      KAKENHI-PROJECT-16591082
  • [Journal Article] Plasma KL-6 predicts the development and outcome of bronchopulmonary dysplasia2006

    • Author(s)
      Tohru Ogihara, Kazuya Hirano, Takao Morinobu, Han-Suk Kim, Satoru Ogawa, Mayo Hiroi, Shinya Oue, Ryoichi Ban, Seigo Hira, Masashi Hasegawa, Shigeo Yamaoka, Masako Yasui
    • Journal Title

      Pediatric Research 60

      Pages: 613-618

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591082
  • [Journal Article] Plasma KL-6 predicts the development and outcome of bronchopulmonary dysplasia2006

    • Author(s)
      Tohru Ogihara, Kazuya Hirano, Takao Morinobu, Han-Suk Kim, Satoru Ogawa, Mayo Hiroi, Shinya Oue, Ryoichi Ban, Seigo Hira, Masashi Hasegawa, Shigeo Yamaoka, Masako Yasui
    • Journal Title

      Pediat Res. 60

      Pages: 613-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591082
  • [Journal Article] Regulation of apoptosis by glutathione redox state in PC12 Cells exposed simultaneously to iron and ascorbic acid2005

    • Author(s)
      Mayo Hiroi, Tohru Ogihara, Kazuya Hirano, Masashi Hasegawa, Takao Morinobu, Hiroshi Tamai, Etsuo Niki
    • Journal Title

      Free Radical Biology and Medicine 38

      Pages: 1057-1072

    • Data Source
      KAKENHI-PROJECT-16591082
  • [Journal Article] Regulation of apoptosis by glutathione redox state in PC12 cells exposed simultaneously to iron and ascorbic acid.2005

    • Author(s)
      Hiroi M, Ogihara T, Hirano K, Hasegawa M, Morinobu T, Tamai H, Niki E
    • Journal Title

      Free Radical Biology and Medicine 38

      Pages: 1057-1072

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591082
  • [Journal Article] Venepuncture is preferable to heel lance for blood sampling in term neonates2005

    • Author(s)
      Satoru Ogawa, Tohru Ogihara, Emi Fujiwara, Kazumi Ito, Mutsumi Nakano, Satsuki Nakayama, Tomomi Hachiya, Naomi Fujimoto, Hiroko Abe, Satoko Ban, Etsuko Ikeda, Hiroshi Tamai
    • Journal Title

      Archives of Disease in Childhood Fetal Neonatal Edition (In press)

    • Data Source
      KAKENHI-PROJECT-16591082
  • [Journal Article] Regulation of apoptosis by glutathione redox state in PC12 cells exposed simultaneously to iron and ascorbic acid.2005

    • Author(s)
      Hiroi M, Ogihara T, Hirano K, Hasegawa M, Morinobu T, Tamai H, Niki E.
    • Journal Title

      Free Radic Biol Med. 38

      Pages: 1057-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591082
  • [Journal Article] Moderate hypothermia inhibits the death of differentiated PC12 cells mediated by simultaneous exposure to iron and ascorbic acid.

    • Author(s)
      Hasegawa M, Ogihara T, Hiroi M, Tamai H.
    • Journal Title

      J Neurochem (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591082
  • [Presentation] Bleomycin誘発BPDモデルに対する抗炎症性脂質メディエーターの有効性について2016

    • Author(s)
      篠原潤、桝田翠、山岡繁夫、長谷川昌史、荻原享
    • Organizer
      日本新生児成育医学会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-12-02
    • Data Source
      KAKENHI-PROJECT-25461657
  • [Presentation] 炎症性疾患としての CLD ー 視点 を変えれば、新たな可能性が?見?えてくる2011

    • Author(s)
      荻原 享
    • Organizer
      日本未熟児新生児学会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-13
    • Data Source
      KAKENHI-PROJECT-22591211
  • [Presentation] 新生児にとって酸素はそんなに危険なのだろうか2007

    • Author(s)
      荻原 享
    • Organizer
      第52回日本未熟児新生児学会
    • Place of Presentation
      香川
    • Year and Date
      2007-11-26
    • Data Source
      KAKENHI-PROJECT-19591289
  • [Presentation] Non-resolving inflammationとしてのCLD~新たな視点から、次世代の予防・治療法を考える~

    • Author(s)
      荻原 享
    • Organizer
      近畿新生児研究会
    • Place of Presentation
      大阪
    • Invited
    • Data Source
      KAKENHI-PROJECT-22591211
  • 1.  TAMAI Hiroshi (30179874)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 6 results
  • 2.  MINO Makoto (70090206)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  KITAGAWA Makoto (70175298)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  岡本 良三 (80131324)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  YOSHIDA Yasukazu (90358333)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  KAWAMURA N (50247863)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  SUZUKI Shuhei (10278525)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  山岡 繁夫 (90434779)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 9.  OUE Shinya (40399085)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 10.  YASUDA Hiroshi (10220154)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  長谷川 昌史 (80388264)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  安井 昌子 (70550218)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  近藤 園子 (70437680)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  安田 真之 (00380155)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  中村 信嗣 (30437686)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  日下 隆 (50274288)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  真砂 光宏
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  永井 章
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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