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chayama Kazuaki  茶山 一彰

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Chayama Kazuaki  茶山 一彰

CHAYAMA Kazuaki  茶山 一彰

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Researcher Number 00211376
Other IDs
Affiliation (Current) 2025: 公益財団法人広島生命科学研究所(研究部門), 研究部門, 研究所長
Affiliation (based on the past Project Information) *help 2025: 公益財団法人広島生命科学研究所(研究部門), 研究部門, 研究所長
2021 – 2023: 広島大学, 医系科学研究科(医), 共同研究講座教授
2019: 広島大学, 医系科学研究科(医), 教授
2017 – 2018: 広島大学, 医歯薬保健学研究科(医), 教授
2016: 広島大学, 医歯薬保健学研究院, 教授 … More
2013 – 2016: 広島大学, 医歯薬保健学研究院(医), 教授
2012 – 2014: 広島大学, 医歯薬保健学研究院, 教授
2012: 広島大学, 大学院・医歯薬保健学研究院, 教授
2009 – 2011: Hiroshima University, 大学院・医歯薬学総合研究科, 教授
2007: Hiroshima University, Graduate School of Biomedical Sciences, Professor
2006: 広島大学, 大学院医歯薬学総合研究科, 教授
2005: 広島大学, 大学院・分子病態制御内科学, 教授
2004: 広島大学, 大学院・医歯薬総合研究科, 教授
2002 – 2003: 広島大学, 大学院・医歯薬学総合研究科, 教授
2000 – 2001: Hiroshima University, Faculty of Medicine, Professor., 医学部, 教授
1999: 財団法人 冲中記念成人病研究所, 研究員
1998: 冲中記念成人病研究所, 研究員
1995: Research associate Okinaka Memorial Institute for Medical Research, 研究員
1994 – 1995: (財)冲中記念成人病研究所, 研究員 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Gastroenterology / Basic Section 53010:Gastroenterology-related / Medium-sized Section 52:General internal medicine and related fields / General internal medicine and related fields
Except Principal Investigator
Gastroenterology
Keywords
Principal Investigator
mutation / lamivudine / C型肝炎ウイルス / PCR / 肝臓学 / キメラマウス / ゲノム / ヒト肝細胞 / ヒト肝細胞キメラマウス / mRNA … More / hepatitis C virus / B型肝炎ウイルス / resistance / PCR-RFLP / インターフェロン / ISDR / ゲノム / interferon / 肝炎ウイルス / 肥満 / モデル動物 / NASH / 脂肪肝 / 治療 / 線維化 / 成長ホルモン / 脂肪化 / ゲノム編集 / cas9 / lentivirus / cancer therapy / dsDNA / exosome / genome editing / HepG2 / HepaRG / NTCP / Hepg2 / therapeutic drug / human hepatocyte chimeric mouse / microarray / expression profile / interferon stimulated genes / 免疫 / 治療薬 / マイクロアレイ / 発現プロファイル / 誘導遺伝子 / replicon / full length clone / acute hepatitis / chronic hepatitis / polymerase chain reaction / protease / helicase / polymerase / IRFファミリー / RNA interference / IFN-β / HCV infectiousclone / IFN / HCV infectious clone / クローニング / RT-PCR / HCV / replication / HBV DNA / HBe antigen / HBs antigen / hepatitis B virus / 薬剤耐性 / whole genome / real time PCR / HBV / YMDDvariant / adefovir / core promoter / pre-Core / peptide nucleic acid / YMDD変異株 / YMDD野生株 / lamibudine / YIDD / YVDD / YMDDモチーフ / ラミブジン / 点突然変異 / 長期投与 / YMDD / amino acid sequence / Hepatitis C virus / アミノ酸配列 / C型肝炎 / transplantation / microRNA / digital PCR / SNP / 次世代シーケンサー / 肝細胞キメラマウス / ウイルス / 肝細胞キメラマウス / 細胞・組織 / ウイルス、ゲノム / uPA scid mouse / 不死化肝細胞 / トランスジェニックマウス / ノックアウトマウス / GS EA / IFN誘導遺伝子 / cDNA micro array / 発現亢進 / 発現抑制 / 転写 / 劇症肝炎 … More
Except Principal Investigator
筋線維芽細胞 / インテグリンα8β1 / 線維化 / TGF-β / 抗体医薬 / 肝線維症 / インテグリン / Fibrosis / α-SMA / Integrin α8β1 / 肝線維化 / 肝臓 / YAP1 / YAP-1 / TGFβ / 腎硬化症 / 阻害抗体 / 腎線維症 / 肝硬変 / α-smooth muscle actin / 肺線維症 / ノックアウトマウス / stellate cell / myofibroblast / integrin / antibody drug / fibrosis / C型肝炎ウィルス / HCV / ヒト肝細胞キメラマウス / インターフェロン / C型肝炎ウイルス / キメラマウス / scidマウス / uPA / ヒト肝細胞移植 Less
  • Research Projects

    (18 results)
  • Research Products

    (507 results)
  • Co-Researchers

    (61 People)
  •  ヒト肝細胞MASHモデルを使用した肝細胞死と線維化をきたす肝細胞要因の解明Principal Investigator

    • Principal Investigator
      茶山 一彰
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Public Interest Incorporated Foundation Hiroshima Institute of Life Sciences
  •  Study of NASH using human hepatocyte chimeric mouse and biopsy specimenPrincipal Investigator

    • Principal Investigator
      Chayama Kazuaki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Hiroshima University
  •  Establishment of highly safe gene therapy without usage of double stranded DNAPrincipal Investigator

    • Principal Investigator
      Chayama Kazuaki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Research Field
      General internal medicine and related fields
    • Research Institution
      Hiroshima University
  •  Mechanism and therapeutic application of a novel integrin blocking mAb that inhibit liver fibrosis in mice

    • Principal Investigator
      Yokosaki Yasuyuki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Hiroshima University
  •  Development of novel anti-viral treatment using primary human hepatocyte and stable isotope.Principal Investigator

    • Principal Investigator
      CHAYAMA KAZUAKI
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Hiroshima University
  •  A novel anti-integrin monoclonal antibody that attenuates mouse liver fibrosis: Mechanism of action and therapeutic application

    • Principal Investigator
      Yokosaki Yasuyuki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Hiroshima University
  •  Development of animal model mimicking ornithine transcarbamylase deficiencyPrincipal Investigator

    • Principal Investigator
      CHAYAMA KAZUAKI
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Hiroshima University
  •  Identification of SNPs on mature micro RNA to analyze origin of miRNAPrincipal Investigator

    • Principal Investigator
      CHAYAMA Kazuaki
    • Project Period (FY)
      2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Hiroshima University
  •  Analysis of unknown pathogen using human hepatocyte chimeric mouseand massive parallel sequencingPrincipal Investigator

    • Principal Investigator
      CHAYAMA Kazuaki
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Hiroshima University
  •  Generation of a mouse model that shows specific features of human diseases.Principal Investigator

    • Principal Investigator
      CHAYAMA Kazuaki
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Hiroshima University
  •  A comprehensive transcriptome analysis of humanized mouse liver using ultra high density cDNA micro arrayPrincipal Investigator

    • Principal Investigator
      CHAYAMA Kazuaki
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Hiroshima University
  •  人の肝細胞を有するマウスを使用した劇症肝炎等の原因となる新規病態微生物の探索Principal Investigator

    • Principal Investigator
      茶山 一彰
    • Project Period (FY)
      2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Hiroshima University
  •  Production of interferon stimulated gene library and screening of new therapeutic drug for hepatitis virusesPrincipal Investigator

    • Principal Investigator
      CHAYAMA Kazuaki
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Hiroshima University
  •  ヒト肝細胞移植マウスにおけるHCV感染によるキャリア化と肝炎の誘導

    • Principal Investigator
      高橋 祥一, 石原 浩人
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Hiroshima University
  •  Analysis of lamivudine resistance acquisition by hepatitis B virus.Principal Investigator

    • Principal Investigator
      CHAYAMA Kazuaki
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Hiroshima University
  •  Specification of the factor in a liver cell required for multiplication of hepatitis C virusPrincipal Investigator

    • Principal Investigator
      CHAYAMA Kazuaki
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Hiroshima University
  •  Detection of drug resistant mutant hepatitis B virus strain and its clinical application.Principal Investigator

    • Principal Investigator
      CHAYAMA Kazuaki
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Hiroshima University
      Okinaka Memorial Institute for Medical Research
  •  Interferon resistance of hepatitis C virusPrincipal Investigator

    • Principal Investigator
      CHAYAMA Kazuaki
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Okinaka Memorial Institute for Medical Study

All 2024 2022 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2007 2006 Other

All Journal Article Presentation Book Patent

  • [Book] 肝原発平滑筋肉腫の一例2019

    • Author(s)
      山岡賢治, 児玉健一郎, 河岡友和, 難波麻衣子, 内川慎介, 大屋一輝, 盛生 慶, 中原隆志, 村上英介, 山内理海, 平松 憲, 今村道雄, 相方 浩, 織田麻琴, 有廣光司, 小林 剛, 大段秀樹, 茶山一彰
    • Publisher
      肝臓
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Book] 日本消化器病学会雑誌2013

    • Author(s)
      茶山一彰, 越智秀典, 三木大樹
    • Total Pages
      13
    • Publisher
      一般財団法人 日本消化器病学会
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] 肝癌診療Q&A2013

    • Author(s)
      相方 浩, 兵庫秀幸, 茶山一彰
    • Total Pages
      4
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] 肝癌診療 Q&A、"最近は肝癌の背景病態 (B型・C型・NASHなど)に変化が起こっていますか?"2013

    • Author(s)
      相方浩,兵庫秀幸,茶山一彰
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] hepatology Practice第1巻 B型肝炎の診療を極める、IV .B型肝炎を理解するための基礎研究 4.HBVの感染実験系2013

    • Author(s)
      柘植雅貴,茶山一彰
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] hepatology Practice第1巻 B型肝炎の診療を極める、III治療編 4.薬物療法の基本方針C薬物療法:合併症の治療2013

    • Author(s)
      兵庫秀幸,茶山一彰
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] 肝臓2013

    • Author(s)
      小林知樹, 川上由育, 平松 憲, 瀧川英彦, 野中裕広, 田中未央, 苗代典昭, 中原隆志, 本田洋士, 宮木大輔, 長沖祐子, 河岡友和, 高木慎太郎, 柘植雅貴, 今村道雄, 兵庫秀幸, 相方 浩, 高橋祥一, 茶山一彰
    • Total Pages
      7
    • Publisher
      一般社団法人日本肝臓学会
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] Pharma Medica、C型肝炎インターフェロン・フリー抗ウイルス治療の展望2013

    • Author(s)
      川上由育,茶山一彰
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] 消化器内科2013

    • Author(s)
      今村道雄, 川上由育, 茶山一彰
    • Total Pages
      4
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] 専門医のための消化器病学会2013

    • Author(s)
      茶山一彰
    • Total Pages
      5
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] 肝臓、ゲノタイプ3a型のC型急性肝炎の1例―IL28B遺伝子からの考察―2013

    • Author(s)
      小林知樹,川上由育,平松憲,瀧川英彦,野中裕広,田中未央,苗代典昭,中原隆志,本田洋士,宮木大輔,長沖祐子,河岡友和,高木慎太郎,柘植雅貴,今村道雄,兵庫秀幸,相方浩,高橋祥一,茶山一彰
    • Publisher
      一般社団法人日本肝臓学会
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] hepatology Practice 第1巻 B型肝炎の診療を極める2013

    • Author(s)
      兵庫秀幸, 茶山一彰
    • Total Pages
      4
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] 専門医のための消化器病学会、B型l肝炎[治療]2013

    • Author(s)
      茶山一彰
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] 消化器の臨床、B型慢性肝炎2013

    • Author(s)
      今村道雄,茶山一彰
    • Publisher
      ヴァンメディカル
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] 日本消化器病学会雑誌、肝疾患の疾患関連遺伝子-GWASを含めた最近の知見から-2013

    • Author(s)
      茶山一彰,越智秀典,三木大樹
    • Publisher
      一般財団法人日本消化器病学会
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] 日本消化器病学会雑誌2013

    • Author(s)
      茶山一彰, 越智秀秀典, 三木大樹
    • Total Pages
      13
    • Publisher
      一般財団法人 日本消化器病学会
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] The Lipid2013

    • Author(s)
      今村道雄, 平賀伸彦, 茶山一彰
    • Total Pages
      4
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] Pharma Medica2013

    • Author(s)
      川上由育, 茶山一彰
    • Total Pages
      4
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] The Lipid、【代謝循環器系薬剤の多面的作用】エゼチミブ2013

    • Author(s)
      今村道雄,平賀伸彦,茶山一彰
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] 消化器内科、【C型慢性肝炎の新たな治療展開】IL28B遺伝子多型からみた3剤併用療法に対する難治性要因2013

    • Author(s)
      今村道雄,川上由育,茶山一彰
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] 消化器の臨床2013

    • Author(s)
      今村道雄, 茶山一彰
    • Total Pages
      7
    • Publisher
      ヴァンメディカル
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] hepatology Practice 第1巻 B型肝炎の診療を極める2013

    • Author(s)
      柘植雅貴, 茶山一彰
    • Total Pages
      8
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] The Lipid、2.エゼチミブ2013

    • Author(s)
      今村道雄,平賀伸彦,茶山一彰
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Book] B型肝炎に関する最近の話題2012

    • Author(s)
      茶山一彰
    • Total Pages
      4
    • Publisher
      広島市内科医会報
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Book] [2]人体への影響 [B]後障害 d.肝がん2012

    • Author(s)
      茶山一彰
    • Total Pages
      8
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Book] 1.総論:ウイルス肝炎・肝癌に関する最新状況2012

    • Author(s)
      茶山一彰
    • Total Pages
      2
    • Publisher
      BIO Clinica
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Book] 特集 消化器疾患の話題 B型肝炎2012

    • Author(s)
      茶山一彰
    • Total Pages
      2
    • Publisher
      MEDICAMENT NEWS
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Book] 特集非B非C型肝厳ー最新の知見わが国における非B非C型肝癌の実態(8)非B非C型k肝癌のリスクの因子2012

    • Author(s)
      茶山一彰
    • Total Pages
      6
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Book] 特集消化器疾患の話題 B 型肝炎2012

    • Author(s)
      茶山一彰
    • Total Pages
      1
    • Publisher
      MEDICAMENT NEWS
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Book] B 型肝炎に関する最近の話題2012

    • Author(s)
      茶山一彰
    • Total Pages
      4
    • Publisher
      広島市内科医会報
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Book] 特集 C 型肝炎治療の最前線 5.テラプレビル耐性変異2012

    • Author(s)
      茶山一彰
    • Total Pages
      7
    • Publisher
      本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Book] 特集 C型肝炎治療の最前線 5.テラプレビル耐性変異2012

    • Author(s)
      茶山一彰
    • Total Pages
      7
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Book] [2]人体への影響[B]後障害 d.肝がん2012

    • Author(s)
      茶山一彰
    • Total Pages
      8
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Book] 1.総論:ウイルス肝炎・肝癌に関する最新状況2012

    • Author(s)
      茶山一彰
    • Total Pages
      1
    • Publisher
      BIO Clinica
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Book] 特集 非B非C型肝厳ー最新の知見わが国における非B非C型肝癌の実態 (8)非B非C型k肝癌のリスクの因子2012

    • Author(s)
      茶山一彰
    • Total Pages
      7
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Journal Article] Multi-omics analysis of a fatty liver model using human hepatocyte chimeric mice.2024

    • Author(s)
      Ichikawa A, Miki D, Hayes CN, Teraoka Y, Nakahara H, Tateno C, Ishida Y, Chayama K, Oka S.
    • Journal Title

      Sci Rep.

      Volume: 14(1) Issue: 1 Pages: 3362-3362

    • DOI

      10.1038/s41598-024-53890-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K07416, KAKENHI-PROJECT-21H04817
  • [Journal Article] Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease.2022

    • Author(s)
      Fujiwara-N, Chayama-K et al.
    • Journal Title

      science translational medicine

      Volume: 14 Issue: 650 Pages: 1-28

    • DOI

      10.1126/scitranslmed.abo4474

    • Data Source
      KAKENHI-PROJECT-21H04817
  • [Journal Article] Preoperative PET-CT is useful for predicting recurrent extrahepatic metastasis of hepatocellular carcinoma after resection.2020

    • Author(s)
      Morio K, Kawaoka T, Aikata H, Namba M, Uchikawa S, Kodama K, Ohya K, Fujino H, Nakahara T, Murakami E, Yamauchi M, Tsuge M, Hiramatsu A, Imamura M, Nakamura Y, Akagi M, Awai K, Kobayashi T, Ohdan H, Chayama K.
    • Journal Title

      Eur J Radiol.

      Volume: 124 Pages: 108828-108828

    • DOI

      10.1016/j.ejrad.2020.108828

    • NAID

      120007097014

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-18K08706
  • [Journal Article] Regression of Idiopathic Thrombocytopenic Purpura in a Patient With Eradication of Hepatitis C Virus by Direct-Acting Antivirals.2020

    • Author(s)
      Johira Y, Hatooka H, Mori N, Fukuhara T, Takaki S, Shimomura Y, Imamura M, Hayes CN, Tsuji K, Chayama K.
    • Journal Title

      Hepatology.

      Volume: 71 Issue: 1 Pages: 389-391

    • DOI

      10.1002/hep.30900

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Complete response to pembrolizumab in advanced hepatocellular carcinoma with microsatellite instability.2020

    • Author(s)
      Ando Y, Yamauchi M, Suehiro Y, Yamaoka K, Kosaka Y, Fuji Y, Uchikawa S, Kodama K, Morio K, Fujino H, Nakahara T, Ono A, Murakami E, Kawaoka T, Takahashi S, Tsuge M, Hiramatsu A, Imamura M, Chayama K, Aikata H.
    • Journal Title

      Clin J Gastroenterol.

      Volume: - Issue: 5 Pages: 867-872

    • DOI

      10.1007/s12328-020-01099-3

    • NAID

      120007167205

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] A Cost-Effectiveness Analysis of Glecaprevir/Pibrentasvir Versus Existing Direct-Acting Antivirals to Treat Chronic Hepatitis C in Japan.2020

    • Author(s)
      Kawaguchi I, Chayama K, Gonzalez YS, Virabhak S, Mitchell D, Yuen C, Kumada H.
    • Journal Title

      Adv Ther.

      Volume: 37 Issue: 1 Pages: 457-476

    • DOI

      10.1007/s12325-019-01166-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Risk factors for histological progression of non-alcoholic steatohepatitis analyzed from repeated biopsy cases.2020

    • Author(s)
      Daijo K, Nakahara T, Inagaki Y, Nanba M, Nishida Y, Uchikawa S, Kodama K, Oya K, Morio K, Fujino H, Ono A, Murakami E, Yamauchi M, Kawaoka T, Miki D, Tsuge M, Hiramatsu A, Hayes CN, Imamura M, Aikata H, Ochi H, Chayama K.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: - Issue: 8 Pages: 1412-1419

    • DOI

      10.1111/jgh.14968

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446, KAKENHI-PROJECT-20K08288, KAKENHI-PROJECT-18K15814
  • [Journal Article] A case of advanced HCC treated with lenvatinib after hepatic arterial infusion chemotherapy combined with radiation therapy treatment for portal vein tumor thrombosis in the main trunk.2020

    • Author(s)
      Kosaka Y, Kawaoka T, Aikata H, Suehiro Y, Yamaoka K, Ando Y, Namba M, Takeuchi Y, Fujii Y, Uchikawa S, Kodama K, Oya K, Morio K, Fujino H, Nakahara T, Murakami E, Yamauchi M, Tsuge M, Hiramatsu A, Imamura M, Baba Y, Awai K, Kimura T, Nagata Y, Chayama K.
    • Journal Title

      Clin J Gastroenterol.

      Volume: - Issue: 5 Pages: 839-843

    • DOI

      10.1007/s12328-020-01093-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Serum miR-379 expression is related to the development and progression of hypercholesterolemia in non-alcoholic fatty liver disease2020

    • Author(s)
      Okamoto, K. Koda, M. Okamoto, T. Onoyama, T. Miyoshi, K. Kishina, M. Matono, T. Kato, J. Tokunaga, S. Sugihara, T. Hiramatsu, A. Hyogo, H. Tobita, H. Sato, S. Kawanaka, M. Hara, Y. Hino, K. Chayama, K. Murawaki, Y. Isomoto, H.
    • Journal Title

      PLoS One

      Volume: 15 Issue: 2 Pages: e0219412-e0219412

    • DOI

      10.1371/journal.pone.0219412

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03644, KAKENHI-PROJECT-17H06269
  • [Journal Article] Classification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations.2020

    • Author(s)
      Fujita M, Yamaguchi R, Hasegawa T, Shimada S, Arihiro K, Hayashi S, Maejima K, Nakano K, Fujimoto A, Ono A, Aikata H, Ueno M, Hayami S, Tanaka H, Miyano S, Yamaue H, Chayama K, Kakimi K, Tanaka S, Imoto S, Nakagawa H.
    • Journal Title

      EBioMedicine

      Volume: 53 Pages: 102659-102659

    • DOI

      10.1016/j.ebiom.2020.102659

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10675, KAKENHI-PROJECT-18K19426, KAKENHI-PROJECT-18H04049, KAKENHI-PROJECT-19H01055, KAKENHI-PROJECT-18H02680, KAKENHI-PROJECT-18H02696, KAKENHI-PROJECT-18H03328, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09426, KAKENHI-PROJECT-18K19575, KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-19K09206
  • [Journal Article] Incidence of microsatellite instability-high hepatocellular carcinoma among Japanese patients and response to pembrolizumab.2020

    • Author(s)
      Kawaoka T, Ando Y, Yamauchi M, Suehiro Y, Yamaoka K, Kosaka Y, Fuji Y, Uchikawa S, Morio K, Fujino H, Nakahara T, Ono A, Murakami E, Takahashi S, Tsuge M, Hiramatsu A, Imamura M, Chayama K, Aikata H.
    • Journal Title

      Hepatol Res.

      Volume: - Issue: 7 Pages: 885-888

    • DOI

      10.1111/hepr.13496

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09426
  • [Journal Article] Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma.2020

    • Author(s)
      Juhling F, Hamdane N, Crouchet E, Li S, El Saghire H, Mukherji A, Fujiwara N, Oudot MA, Thumann C, Saviano A, Roca Suarez AA, Goto K, Masia R, Sojoodi M, Arora G, Aikata H, Ono A, Tabrizian P, Schwartz M, Polyak SJ, Davidson I, Schmidl C, Chayama K, et al.
    • Journal Title

      Gut.

      Volume: - Issue: 1 Pages: 157-169

    • DOI

      10.1136/gutjnl-2019-318918

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Population Pharmacokinetics of Glecaprevir/Pibrentasvir in HCV-infected Japanese Subjects in Phase 3 CERTAIN-1 and CERTAIN-2 Trials.2020

    • Author(s)
      Suleiman AA, Lin CW, Liu W, Eckert D, Mensing S, Burroughs M, Kato K, Chayama K, Kumada H, Oberoi RK.
    • Journal Title

      J Clin Pharmacol.

      Volume: 60 Issue: 3 Pages: 331-339

    • DOI

      10.1002/jcph.1524

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Three Children Treated with Direct-acting Antivirals for Chronic Hepatitis C Virus Genotype 1b Infection2020

    • Author(s)
      Ohya K, Kawaoka T, Imamura M, Morio K, Nakahara T, Murakami E, Yamauchi M, Hiramatsu A, Tsuge M, Aikata H, Chayama K.
    • Journal Title

      Intern. Med.

      Volume: 59 Issue: 7 Pages: 941-944

    • DOI

      10.2169/internalmedicine.3824-19

    • NAID

      130007825289

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2020-04-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection.2020

    • Author(s)
      Cheng X, Uchida T, Xia Y, Umarova R, Liu CJ, Chen PJ, Gaggar A, Suri V, Mucke MM, Vermehren J, Zeuzem S, Teraoka Y, Osawa M, Aikata H, Tsuji K, Mori N, Hige S, Karino Y, Imamura M, Chayama K, Liang TJ.
    • Journal Title

      J Clin Invest.

      Volume: - Issue: 6 Pages: 3205-3220

    • DOI

      10.1172/jci135616

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09426, KAKENHI-PROJECT-17K09427
  • [Journal Article] JNJ-4178 (adafosbuvir, odalasvir, and simeprevir) in Japanese patients with chronic hepatitis C virus genotype 1 or 2 infection with or without compensated cirrhosis: The Phase IIa OMEGA-3 study.2020

    • Author(s)
      Takehara T, Chayama K, Kurosaki M, Yatsuhashi H, Tanaka Y, Hiramatsu N, Sakamoto N, Asahina Y, Nozaki A, Nakano T, Hagiwara Y, Shimizu H, Yoshida H, Huang Y, Biermer M, Vijgen L, Hayashi N.
    • Journal Title

      J Gastroenterol

      Volume: - Issue: 6 Pages: 640-652

    • DOI

      10.1007/s00535-020-01672-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03635, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K19647
  • [Journal Article] Management of refractory ascites attenuates muscle mass reduction and improves survival in patients with decompensated cirrhosis.2020

    • Author(s)
      Namba M, Hiramatsu A, Aikata H, Kodama K, Uchikawa S, Ohya K, Morio K, Fujino H, Nakahara T, Murakami E, Yamauchi M, Kawaoka T, Tsuge M, Imamura M, Chayama K.
    • Journal Title

      J Gastroenterol.

      Volume: 55 Issue: 2 Pages: 217-226

    • DOI

      10.1007/s00535-019-01623-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Publisher Correction: Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP.2020

    • Author(s)
      Makokha GN, Abe-Chayama H, Chowdhury S, Hayes CN, Tsuge M, Yoshima T, Ishida Y, Zhang Y, Uchida T, Tateno C, Akiyama R, Chayama K.
    • Journal Title

      Sci Rep.

      Volume: 10 Issue: 1 Pages: 2233-2233

    • DOI

      10.1038/s41598-020-58888-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Successful retreatment with 12 weeks of glecaprevir and pibrentasvir for a genotype 2a HCV-infected hemodialysis patient who failed to respond to 8 weeks of prior glecaprevir and pibrentasvir therapy.2020

    • Author(s)
      Ohya K, Imamura M, Osawa M, Teraoka Y, Morio K, Fujino H, Ono A, Nakahara T, Murakami E, Yamauchi M, Kawaoka T, Hiramatsu A, Tsuge M, Aikata H, Hayes CN, Chayama K.
    • Journal Title

      Clin J Gastroenterol.

      Volume: 13 Issue: 2 Pages: 267-270

    • DOI

      10.1007/s12328-019-01039-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Early changes in ammonia levels and liver function in patients with advanced hepatocellular carcinoma treated by lenvatinib therapy.2019

    • Author(s)
      Ohya K, Kawaoka T, Namba M, Uchikawa S, Kodama K, Morio K, Nakahara T, Murakami E, Hiramatsu A, Tsuge M, Yamauchi M, Imamura M, Chayama K, Aikata H.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 12101-12101

    • DOI

      10.1038/s41598-019-48045-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] HOMA-IR: An independent predictor of advanced liver fibrosis in nondiabetic non-alcoholic fatty liver disease.2019

    • Author(s)
      Fujii H, Yoneda M, et al.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: in press Issue: 8 Pages: 1-6

    • DOI

      10.1111/jgh.14595

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07637, KAKENHI-PROJECT-17K15866, KAKENHI-PROJECT-17K09437, KAKENHI-PROJECT-19H03641, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09434
  • [Journal Article] Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice2019

    • Author(s)
      Tsushima K, Tsuge M, Hiraga N, Uchida T, Murakami E, Makokha GN, Kurihara M, Nomura Motonobu, Hiyama Y, Fujino H, Ono A, Nakahara T, Yamauchi M, Abe-Chayama H, Kawaoka T, Miki D, Imamura M, Aikata H, Hayes CN, Chayama K
    • Journal Title

      Journal of Gastroenterology

      Volume: 印刷中 Issue: 7 Pages: 650-659

    • DOI

      10.1007/s00535-019-01558-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07973, KAKENHI-PROJECT-17KK0194, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446
  • [Journal Article] Ribavirin induces hepatitis C virus genome mutations in chronic hepatitis patients who failed to respond to prior daclatasvir plus asunaprevir therapy.2019

    • Author(s)
      Saito Y, Imamura M, Uchida T, Osawa M, Teraoka Y, Fujino H, Nakahara T, Ono A, Murakami E, Kawaoka T, Miki D, Tsuge M, Serikawa M, Aikata H, Abe-Chayama H, Hayes CN, Chayama K.
    • Journal Title

      J Med Virol.

      Volume: 92 Issue: 2 Pages: 210-218

    • DOI

      10.1002/jmv.25602

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446
  • [Journal Article] Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus-Infected Cells and Liver to Identify Pathways Associated With Disease Development.2019

    • Author(s)
      Lupberger J, Croonenborghs T, Roca Suarez AA, Van Renne N, Juhling F, Oudot MA, Virzi A, Bandiera S, Jamey C, Meszaros G, Brumaru D, Mukherji A, Durand SC, Heydmann L, Verrier ER, El Saghire H, Hamdane N, Bartenschlager R, Fereshetian S, Ramberger E, Sinha R, Nabian M, Chayama K. et al.
    • Journal Title

      Gastroenterology.

      Volume: 157 Issue: 2 Pages: 537-551.e9

    • DOI

      10.1053/j.gastro.2019.04.003

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice.2019

    • Author(s)
      Osawa M, Uchida T, Imamura M, Teraoka Y, Fujino H, Nakahara T, Ono A, Murakami E, Kawaoka T, Miki D, Tsuge M, Hiramatsu A, Abe-Chayama H, Hayes CN, Makokha GN, Aikata H, Ishida Y, Tateno C, Miyayama Y, Hijikata M, Chayama K.
    • Journal Title

      J Gen Virol.

      Volume: 100 Issue: 7 Pages: 1123-1131

    • DOI

      10.1099/jgv.0.001268

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446
  • [Journal Article] Management of HCV patients in cases of direct-acting antiviral failure.2019

    • Author(s)
      Hayes CN, Imamura M, Chayama K.
    • Journal Title

      Expert Rev Gastroenterol Hepatol.

      Volume: 13 Issue: 9 Pages: 839-848

    • DOI

      10.1080/17474124.2019.1651642

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011-2015 update.2019

    • Author(s)
      Tateishi R, Uchino K, Fujiwara N, Takehara T, Okanoue T, Seike M, Yoshiji H, Yatsuhashi H, Shimizu M, Torimura T, Moriyama M, Sakaida I, Okada H, Chiba T, Chuma M, Nakao K, Isomoto H, Sasaki Y, Kaneko S, Masaki T, Chayama K, Koike K.
    • Journal Title

      J Gastroenterol.

      Volume: 54 Issue: 4 Pages: 367-376

    • DOI

      10.1007/s00535-018-1532-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09340, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-18K07945, KAKENHI-PROJECT-19K08465, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-18H02798
  • [Journal Article] Pruritus in patients with chronic liver disease and serum autotaxin levels in patients with primary biliary cholangitis.2019

    • Author(s)
      Fujino H, Tanaka M, Imamura M, Morio K, Ono A, Nakahara T, Murakami E, Kawaoka T, Takahashi S, Miki D, Tsuge M, Hiramatsu A, Aikata H, Hayes CN, Chayama K.
    • Journal Title

      BMC Gastroenterol.

      Volume: 19 Issue: 1 Pages: 169-169

    • DOI

      10.1186/s12876-019-1092-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446
  • [Journal Article] Reply: Hepatectomy versus stereotactic body radiotherapy for primary early hepatocellular carcinoma: A propensity -matched analysis in a single institution.2019

    • Author(s)
      Nakano R, Ohira M, Kobayashi T, Ide K, Tahara H, Kuroda S, Shimizu S, Kimura T, Nagata Y, Aikata H, Chayama K, Ohdan H.
    • Journal Title

      Surgery.

      Volume: 165 Issue: 5 Pages: 1054-1057

    • DOI

      10.1016/j.surg.2018.10.022

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K10669
  • [Journal Article] eVIDENCE: a practical variant filtering for low-frequency variants detection in cell-free DNA2019

    • Author(s)
      Mizuno Kei、Akamatsu Shusuke、Sumiyoshi Takayuki、Wong Jing Hao、Fujita Masashi et al.
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 15017-15017

    • DOI

      10.1038/s41598-019-51459-4

    • NAID

      120006734882

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09206, KAKENHI-PROJECT-18K19426, KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-17H01580, KAKENHI-PROJECT-18H02680, KAKENHI-PROJECT-17H06269
  • [Journal Article] Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP2019

    • Author(s)
      Makokha Grace Naswa、Abe-Chayama Hiromi、Chowdhury Sajeda、Hayes C. Nelson、Tsuge Masataka、Yoshima Tadahiko、Ishida Yuji、Zhang Yizhou、Uchida Takuro、Tateno Chise、Akiyama Rie、Chayama Kazuaki
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 8462-8462

    • DOI

      10.1038/s41598-019-44934-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07973, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17KK0194
  • [Journal Article] Real-world virological efficacy and safety of daclatasvir/asunaprevir/beclabuvir in patients with chronic hepatitis C virus genotype 1 infection in Japan.2019

    • Author(s)
      Takaguchi K, Toyoda H, Tsutsui A, Suzuki Y, Nakamuta M, Imamura M, Senoh T, Nagano T, Tada T, Tachi Y, Hiraoka A, Michitaka K, Shibata H, Joko K, Okubo H, Tsuji K, Takaki S, Watanabe T, Ogawa C, Chayama K, Kumada T, Kudo M, Kumada H.
    • Journal Title

      J Gastroenterol.

      Volume: 54 Issue: 8 Pages: 742-751

    • DOI

      10.1007/s00535-019-01568-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Comparative study on the replication of HCV1b genome between wild-type and cell culture-adaptive mutant in regard to sensitivities against anti-HCV drugs.2019

    • Author(s)
      Miyayama Y, Lee H, Song H, Abe-Chayama H, Miki D, Imamura M, Chayama K, Hijikata M.
    • Journal Title

      Microbiol Immunol.

      Volume: - Issue: 4 Pages: 296-303

    • DOI

      10.1111/1348-0421.12768

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446
  • [Journal Article] Percutaneous transvenous shunt occlusion for portosystemic encephalopathy due to lenvatinib administration to a patient with hepatocellular carcinoma and portosystemic shunt.2019

    • Author(s)
      Namba M, Kawaoka T, Aikata H, Kodama K, Uchikawa S, Ohya K, Morio K, Fujino H, Nakahara T, Murakami E, Yamauchi M, Tsuge M, Hiramatsu A, Imamura M, Baba Y, Awai K, Chayama K.
    • Journal Title

      Clin J Gastroenterol.

      Volume: 12 Issue: 4 Pages: 341-346

    • DOI

      10.1007/s12328-019-00938-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response.2019

    • Author(s)
      Hamdane N, Juhling F, Crouchet E, El Saghire H, Thumann C, Oudot MA, Bandiera S, Saviano A, Ponsolles C, Roca Suarez AA, Li S, Fujiwara N, Ono A, Davidson I, Bardeesy N, Schmidl C, Bock C, Schuster C, Lupberger J, Habersetzer F, Doffoel M, Piardi T, Sommacale D, Imamura M, Chayama K. et al.
    • Journal Title

      Gastroenterology.

      Volume: 156 Issue: 8 Pages: 2313-2329.e7

    • DOI

      10.1053/j.gastro.2019.02.038

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Clinical features of hepatocellular carcinoma in nonalcoholic fatty liver disease patients without advanced fibrosis2019

    • Author(s)
      Kodama Kazuhisa、Kawaguchi Takumi、Hyogo Hideyuki、Nakajima Tomoaki、Ono Masafumi、Sumida Yoshio、Kamada Yoshihiro、Fujii Hideki、Seko Yuya、Takehara Tetsuo、Itoh Yoshito、Nakajima Atsushi、Masaki Naohiko、Torimura Takuji、Saibara Toshiji、Karino Yoshiyasu、Chayama Kazuaki、Tokushige Katsutoshi
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: in press Issue: 9 Pages: 1626-1632

    • DOI

      10.1111/jgh.14608

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04810, KAKENHI-PROJECT-17H06269
  • [Journal Article] The impact of interferon-free direct-acting antivirals on clinical outcome after curative treatment for hepatitis C virus-associated hepatocellular carcinoma: Comparison with interferon-based therapy.2019

    • Author(s)
      Nagaoki Y, Imamura M, Nishida Y, Daijo K, Teraoka Y, Honda F, Nakamura Y, Morio K, Fujino H, Nakahara T, Kawaoka T, Tsuge M, Hiramatsu A, Kawakami Y, Miki D, Hiyama Y, Ochi H, Chayama K, Aikata H.
    • Journal Title

      J Med Virol.

      Volume: 91 Issue: 4 Pages: 650-658

    • DOI

      10.1002/jmv.25352

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09446, KAKENHI-PROJECT-17H06269
  • [Journal Article] Integrated analysis of 8-week glecaprevir/pibrentasvir in Japanese and overseas patients without cirrhosis and with hepatitis C virus genotype 1 or 2 infection.2019

    • Author(s)
      Naganuma A, Chayama K, Notsumata K, Gane E, Foster GR, Wyles D, Kwo P, Crown E, Bhagat A, Mensa FJ, Otani T, Larsen L, Burroughs M, Kumada H.
    • Journal Title

      J Gastroenterol.

      Volume: 54 Issue: 8 Pages: 752-761

    • DOI

      10.1007/s00535-019-01569-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Isolated cardiac metastases of hepatocellular carcinoma after resection: a case report.2019

    • Author(s)
      Tamura Y, Kawaoka T, Aikata H, Namba M, Fujii Y, Morio K, Murakami E, Yamauchi M, Hiramatsu A, Nakahara T, Imamura M, Maruhashi T, Kobayashi T, Ohdan H, Kimura T, Nagata Y, Arihiro K, Chayama K.
    • Journal Title

      Clin J Gastroenterol.

      Volume: - Issue: 3 Pages: 421-427

    • DOI

      10.1007/s12328-019-01075-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes2019

    • Author(s)
      Xue Ruidong、Chen Lu、Zhang Chong、Fujita Masashi et al.
    • Journal Title

      Cancer Cell

      Volume: 35 Issue: 6 Pages: 932-947

    • DOI

      10.1016/j.ccell.2019.04.007

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09206, KAKENHI-PROJECT-18H04049, KAKENHI-PROJECT-17H06269
  • [Journal Article] Efficacy of a self-management program in patients with chronic viral hepatitis in China.2019

    • Author(s)
      Cui Y, Moriyama M, Chayama K, Liu Y, Ya C, Muzembo BA, Rahman MM.
    • Journal Title

      BMC Nurs.

      Volume: 18 Issue: 1 Pages: 44-44

    • DOI

      10.1186/s12912-019-0366-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K19816
  • [Journal Article] Sinusoidal obstruction syndrome post-treatment with trastuzumab emtansine (T-DM1) in advanced breast cancer.2019

    • Author(s)
      Fujii Y, Doi M, Tsukiyama N, Hattori Y, Ohya K, Shiroma N, Morio K, Morioka T, Aikata H, Shinozaki K, Chayama K.
    • Journal Title

      Int Cancer Conf J.

      Volume: 9 Issue: 1 Pages: 18-23

    • DOI

      10.1007/s13691-019-00392-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis.2019

    • Author(s)
      Yen CJ, Yang ST, Chen RY, Huang W, Chayama K, Lee MH, Yang SJ, Lai HS, Yen HY, Hsiao YW, Wang JM, Lin YJ, Hung LY.
    • Journal Title

      J Biomed Sci.

      Volume: 26 Issue: 1 Pages: 44-44

    • DOI

      10.1186/s12929-019-0534-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Correlation between Early Tumor Marker Response and Imaging Response in Patients with Advanced Hepatocellular Carcinoma Treated with Lenvatinib.2019

    • Author(s)
      Kodama K, Kawaoka T, Namba M, Uchikawa S, Ohya K, Morio K, Nakahara T, Murakami E, Yamauchi M, Hiramatsu A, Imamura M, Chayama K, Aikata H.
    • Journal Title

      Oncology.

      Volume: 97 Issue: 2 Pages: 75-81

    • DOI

      10.1159/000499715

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] The Role of Lipids in Hepatocellular Carcinoma.2019

    • Author(s)
      Hayes CN, Zhang P, Chayama K.
    • Journal Title

      Hepatocellular Carcinoma.

      Volume: -

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis.2018

    • Author(s)
      Van Renne N, Roca Suarez AA, Duong FHT, Gondeau C, Calabrese D, Fontaine N, Ababsa A, Bandiera S, Croonenborghs T, Pochet N, De Blasi V, Pessaux P, Piardi T, Sommacale D, Ono A, Chayama K, Fujita M, Nakagawa H, Hoshida Y, Zeisel MB, Heim MH, Baumert TF, Lupberger J.
    • Journal Title

      Gut.

      Volume: 67 Issue: 5 Pages: 953-962

    • DOI

      10.1136/gutjnl-2016-312270

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers.2018

    • Author(s)
      Furuta M, Tanaka H, Shiraishi Y, Unida T, Imamura M, Fujimoto A, Fujita M, Sasaki-Oku A, Maejima K, Nakano K, Kawakami Y, Arihiro K, Aikata H, Ueno M, Hayami S, Ariizumi SI, Yamamoto M, Gotoh K, Ohdan H, Yamaue H, Miyano S, Chayama K, Nakagawa H.
    • Journal Title

      Oncotarget.

      Volume: 9 Issue: 38 Pages: 25075-25088

    • DOI

      10.18632/oncotarget.25308

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H01580, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-16K15623
  • [Journal Article] Serial profiling of circulating tumor DNA for optimization of anti-VEGF chemotherapy in metastatic colorectal cancer patients.2018

    • Author(s)
      Yamauchi M, Urabe Y, Ono A, Miki D, Ochi H, Chayama K.
    • Journal Title

      Int J Cancer.

      Volume: 142 Issue: 7 Pages: 1418-1426

    • DOI

      10.1002/ijc.31154

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] Genomic Characterization of Biliary Tract Cancers Identifies Driver Genes and Predisposing Mutations2018

    • Author(s)
      Wardell CP, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, Polak P, Kim J, Hatanaka Y, Maejima K, Lawlor RT, Nakanishi Y, Mitsuhashi T et al
    • Journal Title

      J Hepatol

      Volume: - Issue: 5 Pages: 959-969

    • DOI

      10.1016/j.jhep.2018.01.009

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08684, KAKENHI-PROJECT-15H04814, KAKENHI-PROJECT-17K10675, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-17H06269
  • [Journal Article] Interferon stimulated genes and innate immune activation following infection with hepatitis B and C viruses.2017

    • Author(s)
      Hayes CN, Chayama K.
    • Journal Title

      J Med Virol.

      Volume: 89 Issue: 3 Pages: 388-396

    • DOI

      10.1002/jmv.24659

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15293
  • [Journal Article] Mesenchymal Stem Cells Induce Epithelial to Mesenchymal Transition in Colon Cancer Cells through Direct Cell-to-Cell Contact.2017

    • Author(s)
      Takigawa H, Kitadai Y, Shinagawa K, Yuge R, Higashi Y, Tanaka S, Yasui W, Chayama K.
    • Journal Title

      Neoplasia.

      Volume: 19 Issue: 5 Pages: 429-438

    • DOI

      10.1016/j.neo.2017.02.010

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Journal Article] The relationship between HBcrAg and HBV reinfection in HBV related post-liver transplantation patients.2017

    • Author(s)
      Urabe A, Imamura M, Tsuge M, Kan H, Fujino H, Fukuhara T, Masaki K, Kobayashi T, Ono A, Nakahara T, Kawaoka T, Hiramatsu A, Kawakami Y, Aikata H, Hayes CN, Maki N, Ohdan H, Chayama K.
    • Journal Title

      J Gastroenterol.

      Volume: 52 Issue: 3 Pages: 366-375

    • DOI

      10.1007/s00535-016-1240-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15293, KAKENHI-PROJECT-15K09002
  • [Journal Article] Silencing of Discoidin Domain Receptor-1 (DDR1) Concurrently Inhibits Multiple Steps of Metastasis Cascade in Gastric Cancer2017

    • Author(s)
      Yuge R, Kitadai Y, Takigawa H, Naito T, Oue N, Yasui W, Tanaka S, Chayama K
    • Journal Title

      Transl Oncol

      Volume: 11 Issue: 3 Pages: 575-584

    • DOI

      10.1016/j.tranon.2018.02.003

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04713, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-18K07016
  • [Journal Article] HBV culture and infectious systems.2016

    • Author(s)
      Hayes CN, Chayama K.
    • Journal Title

      Hepatology International

      Volume: 無し Issue: 4 Pages: 559-566

    • DOI

      10.1007/s12072-016-9712-y

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15293
  • [Journal Article] Early events in hepatitis B virus infection: From the cell surface to the nucleus.2016

    • Author(s)
      Hayes CN, Zhang Y, Makokha GN, Hasan MZ, Omokoko MD, Chayama K.
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: Volume 31, Issue 2, Issue: 2 Pages: 302-309

    • DOI

      10.1111/jgh.13175

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26860191, KAKENHI-PROJECT-15K15293
  • [Journal Article] RNA exosome complex regulates stability of Hepatitis B Virus's X-mRNA transcript in a Non-Stop mediated (NSD) RNA quality control mechanism.2016

    • Author(s)
      Hussein H. Aly, Junya Suzuki, Koichi Watashi, Kazuaki Chayama, Shin-ichi Hoshino, Makoto Hijikata, Takanobu Kato, and Takaji Wakita
    • Journal Title

      J Biol Chem

      Volume: 291 Issue: 31 Pages: 15958-15974

    • DOI

      10.1074/jbc.m116.724641

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25291004, KAKENHI-PROJECT-15K15293, KAKENHI-PROJECT-26460565
  • [Journal Article] Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection.2016

    • Author(s)
      Tsuge M, Hiraga N, Uchida T, Kan H, Miyaki E, Masaki K, Ono A, Nakahara T, Abe-Chayama H, Zhang Y, Naswa MG, Kawaoka T, Miki D, Imamura M, Kawakami Y, Aikata H, Ochi H, Hayes CN, Chayama K.
    • Journal Title

      Journal of Gastroenterology

      Volume: In press Issue: 11 Pages: 1073-1080

    • DOI

      10.1007/s00535-016-1189-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26860191, KAKENHI-PROJECT-15K15293, KAKENHI-PROJECT-15K09002, KAKENHI-PROJECT-15K09003, KAKENHI-PROJECT-16K19346
  • [Journal Article] Highly multiplexed CRISPR-Cas9-nuclease and Cas9-nickase vectors for inactivation of hepatitis B virus.2016

    • Author(s)
      Sakuma T, Masaki K, Abe-Chayama H, Mochida K, Yamamoto T, Chayama K.
    • Journal Title

      Genes Cells.

      Volume: 21 Issue: 11 Pages: 1253-1262

    • DOI

      10.1111/gtc.12437

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-15K15293, KAKENHI-PROJECT-16K18478
  • [Journal Article] Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir andBMS-788329 combination therapy in human hepatocyte chimeric mice.2016

    • Author(s)
      Uchida T, Hiraga N, Imamura M, Yoshimi S, Kan H, Miyaki E, Tsuge M, Abe H, Hayes CN, Aikata H, Ishida Y, Tateno C, Ellis JD, Chayama K.
    • Journal Title

      Virus Res.

      Volume: 213 Issue: 1 Pages: 62-68

    • DOI

      10.1016/j.jinf.2015.09.038

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-15K15293, KAKENHI-PROJECT-15K09002
  • [Journal Article] Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection2016

    • Author(s)
      Yamamoto, N. Sato, Y. Munakata, T. Kakuni, M. Tateno, C. Sanada, T. Hirata, Y. Murakami, S. Tanaka, Y. Chayama, K. Hatakeyama, H. Hyodo, M. Harashima, H. Kohara, M.
    • Journal Title

      Journal of hepatology

      Volume: 64 Issue: 3 Pages: 547-455

    • DOI

      10.1016/j.jhep.2015.10.014

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19120, KAKENHI-PROJECT-15H04739, KAKENHI-PROJECT-24590565, KAKENHI-PROJECT-26830101, KAKENHI-PUBLICLY-15H01272, KAKENHI-PROJECT-15K15293
  • [Journal Article] Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of Hepatitis B virus to impede the replication of HBV in vitro and in vivo.2016

    • Author(s)
      Leong CR, Funami K, Oshiumi H, Mengao D, Takaki H, Matsumoto M, Aly HH, Watashi K, Chayama K, Seya T.
    • Journal Title

      Oncotarget.

      Volume: 7 Issue: 42 Pages: 68179-68193

    • DOI

      10.18632/oncotarget.11907

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15293, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K19134
  • [Journal Article] Development of new therapies using an animal model of hepatitis virus infection(肝炎ウイルスの動物モデルと治療開発)2015

    • Author(s)
      Chayama K, Imamura M.
    • Journal Title

      Nihon Rinsho.(日本臨床2015年増刊号 新ウイルス性肝炎学)

      Volume: 無し

    • Data Source
      KAKENHI-PROJECT-15K15293
  • [Journal Article] Differences in serum microRNA profiles in hepatitis B and C virus infection.2015

    • Author(s)
      Akamatsu S, Hayes CN, Tsuge M, Miki D, Akiyama R, Abe H, Ochi H, Hiraga N, Imamura M, Takahashi S, Aikata H, Kawaoka T, Kawakami Y, Ohishi W, Chayama K.
    • Journal Title

      J Infect.

      Volume: 70 Issue: 3 Pages: 273-287

    • DOI

      10.1016/j.jinf.2014.10.017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536, KAKENHI-PROJECT-15K09002
  • [Journal Article] The effects of bisphosphonate zoledronic acid in hepatocellular carcinoma, depending on mevalonate pathway.2015

    • Author(s)
      Honda Y, Takahashi S, Zhang Y, Ono A, Murakami E, Shi N, Kawaoka T, Miki D, Tsuge M, Hiraga N, Abe H, Ochi H, Imamura M, Aikata H, Chayama K.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 30 Issue: 3 Pages: 619-627

    • DOI

      10.1111/jgh.12715

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536, KAKENHI-PROJECT-26860191
  • [Journal Article] Long-term outcome of patients with gastric varices treated by balloon-occluded retrograde transvenous obliteration.2014

    • Author(s)
      Naeshiro N, Aikata H, Kakizawa H, Hyogo H, Kan H, Fujino H, Kobayashi T, Fukuhara T, Honda Y, Ohno A, Miyaki D, Kawaoka T, Tsuge M, Hiraga N, Hiramatsu A, Imamura M, Kawakami Y, Takahashi S, Awai K, Chayama K.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 29 Issue: 5 Pages: 1035-1042

    • DOI

      10.1111/jgh.12508

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Journal Article] Efficacy and safety of sitagliptin for the treatment of nonalcoholic fatty liver disease with type 2 diabetes mellitus.2014

    • Author(s)
      Fukuhara T, Hyogo H, Ochi H, Fujino H, Kan H, Naeshiro N, Honda Y, Miyaki D, Kawaoka T, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Aikata H, Chayama K.
    • Journal Title

      Hepatogastroenterology.

      Volume: 61 Pages: 323-328

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Journal Article] A randomized trial of daclatasvir with peginterferon alfa-2b and ribavirin for HCV genotype 1 Infection.2014

    • Author(s)
      Suzuki F, Toyoa J, Ikeda K, Chayama K, Mochida S, Hayashi N, Ishikawa H, Miyagoshi H, Hu W, McPhee F, Hughes
    • Journal Title

      Antiviral Ther

      Volume: in press Issue: 5 Pages: 491-499

    • DOI

      10.3851/imp2730

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461010, KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383
  • [Journal Article] Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization.2014

    • Author(s)
      Hara Y, Yanatori I, Ikeda M, Kiyokage E, Nishina S, Tomiyama Y, Toida K, Kishi F, Kato N, Imamura M, Chayama K, Hino K.
    • Journal Title

      Am J Pathol. 2014

      Volume: 184 Issue: 11 Pages: 3026-39

    • DOI

      10.1016/j.ajpath.2014.07.024

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24659377, KAKENHI-PROJECT-25670374, KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-25293110
  • [Journal Article] Serum asymmetric dimethylarginine levels are independently associated with procollagen III N-terminal peptide in nonalcoholic fatty liver disease patients.2014

    • Author(s)
      Hyogo H. Yamagishi S. Maeda S. Fukami K. Ueda S. Okuda S. Nakahara T. Kimura Y. Ishitobi T, and Chayama K
    • Journal Title

      Clin Exp Med

      Volume: 14 Issue: 1 Pages: 45-51

    • DOI

      10.1007/s10238-012-0223-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383
  • [Journal Article] Impact of alloimmune T cell responses on hepatitis C virus replication in liver transplant recipients.2014

    • Author(s)
      Tanaka Y, Ohira M, Tashiro H, Imamura M, Chayama K, Ohdan H.
    • Journal Title

      Hum Immunol.

      Volume: 75 Issue: 12 Pages: 1259-1267

    • DOI

      10.1016/j.humimm.2014.09.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591880, KAKENHI-PROJECT-26670383
  • [Journal Article] New insight into the enhanced effect of pegylated interferon-α.2014

    • Author(s)
      Abe H, Hayes CN, Chayama K.
    • Journal Title

      Hepatology.

      Volume: 60 Issue: 4 Pages: 1435-1437

    • DOI

      10.1002/hep.27269

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26670383
  • [Journal Article] interferon lambda 4/interleukin-28B haplotype structure and its impact on susceptibility to hepatitis C virus and treatment response in the Japanese population2014

    • Author(s)
      Ochi H, Miki D, Hayes CN, Abe H, Hayashida Y, Kubo M, Chayama K
    • Journal Title

      Journal of General Virology

      Volume: 95巻 Issue: 6 Pages: 1297-306

    • DOI

      10.1099/vir.0.060103-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790702, KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536, KAKENHI-PROJECT-221S0001
  • [Journal Article] Clinical outcome and prognostic factors of patients with hepatocellular carcinoma and extrahepatic metastasis treated with sorafenib.2014

    • Author(s)
      Kawaoka T. Aikata H. Kan H. Fujino H. Fukuhara T. Kobayashi T. Naeshiro N. Miyaki D. Hiramatsu A. Imamura M. Kawakami Y. Hyogo H, and Chayama K
    • Journal Title

      Hepatol Res

      Volume: 印刷中 Issue: 13 Pages: 1320-1328

    • DOI

      10.1111/hepr.12307

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383
  • [Journal Article] Differences in K- ras and mitochondrial DNA mutations and microsatellite instability between colorectal cancers of Vietnamese and Japanese patients.2014

    • Author(s)
      Miwata T, Hiyama T, Quach D, Le H, Hua H, Oka S, Tanaka S, Arihiro K, Chayama K.
    • Journal Title

      BMC Gastroenterol.

      Volume: 14 Issue: 1 Pages: 203-203

    • DOI

      10.1186/s12876-014-0203-0

    • NAID

      120006591468

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Journal Article] Long-Term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-gamma Gene Transfer2014

    • Author(s)
      Takahashi Y. Ando M. Nishikawa M. Hiraga N. Imamura M. Chayama K, and Takakura Y
    • Journal Title

      Hum Gene Ther Clin Dev

      Volume: 25 Issue: 1 Pages: 28-39

    • DOI

      10.1089/humc.2013.066

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383
  • [Journal Article] Interferon lambda 4 polymorphism effects on outcome of telaprevir, pegylated interferon and ribavirin combination therapy for chronic hepatitis C2014

    • Author(s)
      Nagaoki Y, Imamura M, Kawakami Y, Kan H, Fujino H, Fukuhara T, Kobayashi T, Ono A, Nakahara T, Naeshiro N, Urabe A, Yokoyama S, Miyaki D, Murakami E, Kawaoka T, Tsuge M, Hiramatsu A, Aikata H, Takahashi S, Hayes CN, Ochi H, Chayama K
    • Journal Title

      Hepatology Research

      Volume: (印刷中) Issue: 14

    • DOI

      10.1111/hepr.12336

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24790702, KAKENHI-PROJECT-26670383
  • [Journal Article] Endocannabinoid CB1 antagonists inhibit hepatitis C virus production, providing a novel class of antiviral host-targeting agents.2014

    • Author(s)
      Shahidi M, Tay ES, Read SA, Ramezani-Moghadam M, Chayama K, George J, Douglas MW.
    • Journal Title

      J Gen Virol.

      Volume: 95 Issue: 11 Pages: 2468-2479

    • DOI

      10.1099/vir.0.067231-0

    • Data Source
      KAKENHI-PROJECT-26670383
  • [Journal Article] Nonalcoholic fatty liver disease and cardiovascular disease.2014

    • Author(s)
      Hyogo H, Chayama K, Yamagishi S.
    • Journal Title

      Curr Pharm Des.

      Volume: 20 Issue: 14 Pages: 2403-2411

    • DOI

      10.2174/13816128113199990476

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Journal Article] Serum interleukin-6 associated with hepatocellular carcinoma risk: a nested case-control study2014

    • Author(s)
      Waka Ohishi, John B. Cologne, Saeko Fujiwara, Gen Suzuki, Tomonori Hayashi, Yasuharu Niwa, Masazumi Akahoshi, Keiko Ueda, Masataka Tsuge, Kazuaki Chayama
    • Journal Title

      International Journal of Cancer

      Volume: 134巻 Issue: 1 Pages: 154-163

    • DOI

      10.1002/ijc.28337

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23590840, KAKENHI-PROJECT-24390162, KAKENHI-PROJECT-24791023, KAKENHI-PROJECT-25330039, KAKENHI-PROJECT-26670383
  • [Journal Article] Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver disease and metabolic syndrome traits.2014

    • Author(s)
      Kitamoto A, Kitamoto T, Nakamura T, Ogawa Y, Yoneda M, Hyogo H, Ochi H, Mizusawa S, Ueno T, Nakao K, Sekine A, Chayama K, Nakajima A, Hotta K.
    • Journal Title

      Endocr J.

      Volume: 61 Pages: 683-689

    • NAID

      130004677938

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Journal Article] Aryl hydrocarbon receptor plays protective roles in ConA-induced hepatic injury by both suppressing IFN-Y expression and inducing IL-222014

    • Author(s)
      Abe H, Kimura A, Tsuruta S, Fukaya T, Sakaguchi R, et al.
    • Journal Title

      Int Immunol.

      Volume: 26 Issue: 3 Pages: 129-137

    • DOI

      10.1093/intimm/dxt049

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-12J08459, KAKENHI-PUBLICLY-24117718, KAKENHI-PROJECT-25670233, KAKENHI-PROJECT-25670234, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-25221305
  • [Journal Article] Letter : Pitavastatin supplementation of PEG-IFN/ribavirin improves sustained virological response against HCV2014

    • Author(s)
      Yokoyama S, Kawakami Y, and Chayama K
    • Journal Title

      Aliment Pharmacol Ther

      Volume: 39 Issue: 4 Pages: 4-443

    • DOI

      10.1111/apt.12605

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383
  • [Journal Article] Smoking cessation reverses DNA double-strand breaks in human mononuclear cells.2014

    • Author(s)
      Ishida M
    • Journal Title

      PLoS One

      Volume: 9 Issue: 8 Pages: 1-9

    • DOI

      10.1371/journal.pone.0103993

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25640066, KAKENHI-PUBLICLY-26116514, KAKENHI-PROJECT-26461852, KAKENHI-PROJECT-26670383
  • [Journal Article] Two patients treated with pegylated interferon/ribavirin/telaprevir triple therapy for recurrent hepatitis C after living donor liver transplantation.2014

    • Author(s)
      Kawaoka T. Takahashi S. Tatsukawa Y. Hiramatsu A. Hiraga N. Miki D. Tsuge M. Imamura M. Kawakami Y. Aikata H. Ochi H. Ishiyama K. Ide K. Tashiro H. Ohdan H, and Chayama K
    • Journal Title

      Hepatol Res

      Volume: 印刷中 Issue: 12 Pages: 1259-1264

    • DOI

      10.1111/hepr.12296

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536
  • [Journal Article] Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients.2014

    • Author(s)
      Nakahara T, Hyogo H, Yoneda M, Sumida Y, Eguchi Y, Fujii H, Ono M, Kawaguchi T, Imajo K, Aikata H, Tanaka S, Kanemasa K, Fujimoto K, Anzai K, Saibara T, Sata M, Nakajima A, Itoh Y, Chayama K, Okanoue T
    • Journal Title

      J Gastroenterol

      Volume: 49(11) Issue: 11 Pages: 1477-1484

    • DOI

      10.1007/s00535-013-0911-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-26461010, KAKENHI-PROJECT-26461011, KAKENHI-PROJECT-26670383
  • [Journal Article] Evaluation of early response to hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma using the combination of RECIST and tumor markers.2014

    • Author(s)
      Miyaki D, Kawaoka T, Aikata H, Kan H, Fujino H, Fukuhara T, Kobayashi T, Naeshiro N, Honda Y, Tsuge M, Hiramatsu A, Imamura M, Hyogo H, Kawakami Y, Yoshimatsu R, Yamagami T, Awai K, Chayama K.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 30 Issue: 4 Pages: 726-32

    • DOI

      10.1111/jgh.12821

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Journal Article] Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA.2014

    • Author(s)
      Kohno T, Tsuge M, Murakami E, Hiraga N, Abe H, Miki D, Imamura M, Ochi H, Hayes CN, Chayama K.
    • Journal Title

      J Viral Hepat.

      Volume: 21

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Journal Article] Interleukin 28B polymorphism predicts interferon plus ribavirin treatment outcome in patients with hepatitis C virus-related liver cirrhosis: A multicenter retrospective study in Japan.2014

    • Author(s)
      Shakado S, Sakisaka S, Okanoue T, Chayama K, Izumi N, Toyoda J, Tanaka E, Ido A, Takehara T, Yoshioka K, Hiasa Y, Nomura H, Seike M, Ueno Y, Kumada H.
    • Journal Title

      Hepatol Res

      Volume: 44 Issue: 9 Pages: 983-992

    • DOI

      10.1111/hepr.12280

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24590980, KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383
  • [Journal Article] A comparative study of 4 Fr versus 6 Fr nasobiliary drainage catheters: a randomized, controlled trial.2014

    • Author(s)
      Ishigaki T. Sasaki T. Serikawa M. Minami T. Okazaki A. Yukutake M. Ishii Y. Kosaka K. Mouri T. Yoshimi S, and Chayama K
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 29 Issue: 3 Pages: 653-9

    • DOI

      10.1111/jgh.12427

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383
  • [Journal Article] Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection2014

    • Author(s)
      Kumada H, Suzuki Y, Ikeda K, Toyota J, Karino Y, Chayama K, Kawakami Y, Ido A, Yamamoto K, Takaguchi K, Izumi N, Koike K, Takehara T, Kawada N, Sata M, Miyagoshi H, Eley T, McPhee F, Damokosh A, Ishikawa H, and Hughes E
    • Journal Title

      Hepatology

      Volume: (in press) Issue: 6 Pages: 2083-2091

    • DOI

      10.1002/hep.27113

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383
  • [Journal Article] Pilot study of stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma.2014

    • Author(s)
      Honda Y, Kimura T, Aikata H, Nakahara T, Naeshiro N, Tanaka M, Miyaki D, Nagaoki Y, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Ishikawa M, Kakizawa H, Kenjo M, Awai K, Nagata Y, Chayama K.
    • Journal Title

      Hepatogastroenterology.

      Volume: 61 Pages: 31-36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Journal Article] Targeted next-generation sequencing and fine linkage disequilibrium mapping reveals association of PNPLA3 and PARVB with the severity of nonalcoholic fatty liver disease2014

    • Author(s)
      Kitamoto T, Kitamoto A, Yoneda M, Hyogo H, Ochi H, Mizusawa S, Ueno T, Nakao K, Sekine A, Chayama K, Nakajima A, Hotta K
    • Journal Title

      Journal of Human Genetics

      Volume: 6 Issue: 5 Pages: 241-6

    • DOI

      10.1038/jhg.2014.17

    • NAID

      120005477223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461343, KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-25870378, KAKENHI-PROJECT-26670383
  • [Journal Article] Quantitative effect of natural killer-cell licensing on hepatocellular carcinoma recurrence after curative hepatectomy2014

    • Author(s)
      Tanimine N, Tanaka Y, Kobayashi T, Tashiro H, Miki D, Imamura M, Aikata H, Tanaka J, Chayama K, Ohdan H.
    • Journal Title

      Cancer Immunol Res

      Volume: 2(12) Issue: 12 Pages: 1142-1147

    • DOI

      10.1158/2326-6066.cir-14-0091

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25670581, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536
  • [Journal Article] Effect of vitamin D supplementation on pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b: a randomized controlled trial2014

    • Author(s)
      Yokoyama S. Takahashi S. Kawakami Y. Hayes C N. Kohno H. Kohno H. Tsuji K. Aisaka Y. Kira S. Yamashina K. Nonaka M. Moriya T. Kitamoto M. Aimitsu S. Nakanishi T. Kawakami H, and Chayama K
    • Journal Title

      J Viral Hepat

      Volume: 21 Issue: 5 Pages: 348-56

    • DOI

      10.1111/jvh.12146

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383
  • [Journal Article] Ultradeep sequencing study of chronic hepatitis C virus genotype 1 infection in patients treated with daclatasvir, peginterferon, and ribavirin2014

    • Author(s)
      Murakami, E. Imamura, M. Hayes, C. N. Abe, H. Hiraga, N. Honda, Y. Ono, A. Kosaka, K. Kawaoka, T. Tsuge, M. Aikata, H. Takahashi, S. Miki, D. Ochi, H. Matsui, H. Kanai, A. Inaba, T. McPhee, F. Chayama, K.
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 58 Issue: 4 Pages: 2105-2112

    • DOI

      10.1128/aac.02068-13

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591397, KAKENHI-PROJECT-24790701, KAKENHI-PROJECT-24790702, KAKENHI-PROJECT-26461008, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536
  • [Journal Article] Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system2014

    • Author(s)
      Sakuma T, Nishikawa A, Kume S, Chayama K, Yamamoto T
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 5400-5400

    • DOI

      10.1038/srep05400

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26670383
  • [Journal Article] Non-invasive liver fibrosis score calculated by combination of virtual touch tissue quantification and serum liver functional tests in chronic hepatitis C patients2014

    • Author(s)
      Takaki S. Kawakami Y. Miyaki D. Nakahara T. Naeshiro N. Murakami E. Tanaka M. Honda Y. Yokoyama S. Nagaoki Y. Kawaoka T. Hiramatsu A. Tsuge M. Hiraga N. Imamura M. Hyogo H. Aikata H. Takahashi S. Arihiro K, and Chayama K
    • Journal Title

      Hepatol Res

      Volume: 44 Issue: 3 Pages: 280-7

    • DOI

      10.1111/hepr.12129

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383
  • [Journal Article] Stereotactic body radiotherapy for patients with small hepatocellular carcinoma ineligible for resection or ablation therapies.2014

    • Author(s)
      Kimura T, Aikata H, Takahashi S, Takahashi I, Nishibuchi I, Doi Y, Kenjo M, Murakami Y, Honda Y, Kakizawa H, Awai K, Chayama K, Nagata Y.
    • Journal Title

      Hepatol Res.

      Volume: 45 Issue: 4 Pages: 378-86

    • DOI

      10.1111/hepr.12359

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-15H04907
  • [Journal Article] Noninvasive assessment of liver steatosis in nonalcoholic fatty liver disease.2014

    • Author(s)
      Kan H. Kimura Y. Hyogo H. Fukuhara T. Fujino H. Naeshiro N. Honda Y. Kawaoka T. Tsuge M. Hiramatsu A. Imamura M. Kawakami Y. Aikata H. Ochi H. Arihiro K, and Chayama K
    • Journal Title

      Hepatol Res

      Volume: 印刷中 Issue: 14

    • DOI

      10.1111/hepr.12330

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383
  • [Journal Article] The association of insomnia with gastroesophageal reflux symptoms in biopsy-proven nonalcoholic fatty liver disease.2014

    • Author(s)
      Taketani H, Sumida Y, Tanaka S, Imajo K, Yoneda M, Hyogo H, Ono M, Fujii H, Eguchi Y, Kanemasa K, Chayama K, Itoh Y, Yoshikawa T, Saibara T, Fujimoto K, Nakajima A
    • Journal Title

      J Gastroenterol

      Volume: 49(7) Issue: 7 Pages: 1163-1174

    • DOI

      10.1007/s00535-013-0871-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-26461010, KAKENHI-PROJECT-26461011, KAKENHI-PROJECT-26670383
  • [Journal Article] Transarterial therapy of hepatocellular carcinoma fed by the right renal capsular artery.2014

    • Author(s)
      Ishikawa M, Yamagami T, Kakizawa H, Hieda M, Toyota N, Fukumoto W, Kajiwara K, Yoshimatsu R, Aikata H, Chayama K, Awai K.
    • Journal Title

      J Vasc Interv Radiol.

      Volume: 25 Issue: 3 Pages: 389-395

    • DOI

      10.1016/j.jvir.2013.11.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Journal Article] Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers2014

    • Author(s)
      Shiraishi Y, Fujimoto A, Furuta M, Chayama K, Tsunoda T, Miyano S, and Nakagawa H, 他
    • Journal Title

      PLoS One

      Volume: 9 Issue: 12 Pages: e114263-e114263

    • DOI

      10.1371/journal.pone.0114263

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22134008, KAKENHI-PUBLICLY-25134717, KAKENHI-PROJECT-25670375, KAKENHI-PROJECT-26430196, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-221S0001
  • [Journal Article] Emerging treatments for chronic hepatitis C.2014

    • Author(s)
      Hayes CN, Chayama K.
    • Journal Title

      J Formos Med Assoc.

      Volume: 114 Issue: 3 Pages: 204-215

    • DOI

      10.1016/j.jfma.2014.09.001

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Journal Article] Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease.2014

    • Author(s)
      Kessoku T, Ogawa Y, Yoneda M, Imajo K, Sumida Y, Eguchi Y, Fujii H, Hyogo H, Ono M, Suzuki Y, Kawaguchi T, Chayama K, Tanaka S, Fujimoto K, Anzai K, Saibara T, Sata M, Itoh Y, Nakajima A, Okanoue T
    • Journal Title

      World J Gastroenterol

      Volume: 20(29) Issue: 29 Pages: 10108-10114

    • DOI

      10.3748/wjg.v20.i29.10108

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-25860551, KAKENHI-PROJECT-26461010, KAKENHI-PROJECT-26461011, KAKENHI-PROJECT-26670383
  • [Journal Article] Virologic escape in HCV genotype 1-infected patients receiving daclatasvir plus ribavirin and peginterferon alfa-2a or alfa-2b.2014

    • Author(s)
      McPhee F. Hernandez D. Zhou N. Yu F. Ueland J. Monikowski A. Chayama K. Toyota J. Izumi N. Yokosuka O. Kawada N. Osaki Y. Hughes E A. Watanabe H. Ishikawa H, and Kumada H
    • Journal Title

      Antivir Ther

      Volume: 印刷中 Issue: 5 Pages: 479-490

    • DOI

      10.3851/imp2729

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383
  • [Journal Article] Hepatitis C Virus (HCV) Reactivation Caused by Steroid Therapy for Dermatomyositis2014

    • Author(s)
      Mori N, Imamura M, Takaki S, Araki T, Hayes NC, Aisaka Y, Chayama K.
    • Journal Title

      Intern. Med.

      Volume: 53 Issue: 23 Pages: 2689-2693

    • DOI

      10.2169/internalmedicine.53.3194

    • NAID

      130004713280

    • ISSN
      0918-2918, 1349-7235
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Journal Article] The upper limit of normal serum alanine aminotransferase levels in Japanese subjects.2013

    • Author(s)
      Tanaka K,Ono M,Saibara T et.al
    • Journal Title

      Hepatology Research

      Volume: 23 Issue: 12 Pages: 1196-1207

    • DOI

      10.1111/hepr.12293

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26461010, KAKENHI-PROJECT-26461011, KAKENHI-PROJECT-26670383
  • [Journal Article] Case reports of portal vein thrombosis and bile duct stenosis after stereotactic body radiation therapy for hepatocellular carcinoma.2013

    • Author(s)
      Takahashi S. Kimura T. Kenjo M. Nishibuchi I. Takahashi I. Takeuchi Y. Doi Y. Kaneyasu Y. Murakami Y. Honda Y. Aikata H. Chayama K, and Nagata Y
    • Journal Title

      Hepatol Res

      Volume: 電子書籍 Issue: 10

    • DOI

      10.1111/hepr.12241

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383
  • [Journal Article] Identification of a Functional Variant in the MICA Promoter Which Regulates MICA Expression and Increases HCV-Related Hepatocellular Carcinoma Risk.2013

    • Author(s)
      Lo PH, Urabe Y, Kumar V, Tanikawa C, Koike K, Kato N, Miki D, Chayama K, Kubo M, Nakamura Y, Matsuda K.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 4 Pages: e61279-e61279

    • DOI

      10.1371/journal.pone.0061279

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23710316, KAKENHI-PROJECT-24390184, KAKENHI-PUBLICLY-25134707, KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-25710009
  • [Journal Article] Telaprevir is effective given every 12 hours at 750 mg with peginterferon-alfa-2b and ribavirin to Japanese patients with HCV-1b IL28B rs8099917 TT.2013

    • Author(s)
      Kawakami Y. Suzuki F. Karino Y. Toyota J. Kumada H, and Chayama K
    • Journal Title

      Antivir Ther

      Volume: 5 Issue: 3 Pages: 277-285

    • DOI

      10.3851/imp2706

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383
  • [Journal Article] Thromboxane A2 Synthase Inhibitors Prevent Production of Infectious Hepatitis C Virus in Mice with Humanized Livers.2013

    • Author(s)
      Abe Y, Aly HH, Hiraga N, Imamura M, Wakita T, Shimotohno K, Chavama K, Hijikata M.
    • Journal Title

      Gastroenterology

      Volume: 145 Issue: 3 Pages: 658-667

    • DOI

      10.1053/j.gastro.2013.05.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J03908, KAKENHI-PLANNED-22114004, KAKENHI-PROJECT-22249012, KAKENHI-PLANNED-24115003, KAKENHI-PROJECT-25670369
  • [Journal Article] Predictive value of the IFNL4 polymorphism on outcome of telaprevir, peginterferon, and ribavirin therapy for older patients with genotype 1b chronic hepatitis C2013

    • Author(s)
      Fujino H. Imamura M. Nagaoki Y. Kawakami Y. Abe H. Hayes C N.et al
    • Journal Title

      J Gastroenterol

      Volume: 電子書籍 Issue: 12 Pages: 1548-1556

    • DOI

      10.1007/s00535-013-0924-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536
  • [Journal Article] Autologous Bone-Marrow Mesenchymal Stem Cell Implantation and Endothelial Function in a Rabbit Ischemic Limb Model2013

    • Author(s)
      Mikami S, Nakashima A, Nakagawa K, Maruhashi T, Iwamoto Y, Kajikawa M, Matsumoto T, Kihara Y, Chayama K, Noma K, Ochi M, Nishimura M, Tsuji K, Kato Y, Goto C, Higashi Y
    • Journal Title

      PLOS ONE

      Volume: 8(7) Issue: 7 Pages: e67739-e67739

    • DOI

      10.1371/journal.pone.0067739

    • NAID

      120006986197

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390423, KAKENHI-PROJECT-24659876, KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-25670762
  • [Journal Article] Changes in mRNA expression of hypothalamic appetite-regulating peptides during different phases of lactation in rats2013

    • Author(s)
      Suzuki Y,Nakahara K, Maruyama K, Okame R, Ensho T, Inoue Y,Murakami N.
    • Journal Title

      J Mol Endocrinol

      Volume: 52 Issue: 1 Pages: 97-109

    • DOI

      10.1016/j.bbrc.2013.10.040

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23380173, KAKENHI-PROJECT-24658247, KAKENHI-PROJECT-24790701, KAKENHI-PROJECT-24790702, KAKENHI-PROJECT-24791023, KAKENHI-PROJECT-25670369
  • [Journal Article] Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.2013

    • Author(s)
      Kitamoto T
    • Journal Title

      Human Genetics

      Volume: 3 Issue: 7 Pages: 1-10

    • DOI

      10.1007/s00439-013-1294-3

    • NAID

      120005474457

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23701082, KAKENHI-PROJECT-23791027, KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-25870378
  • [Journal Article] Percutaneous transvenous embolization for portosystemic shunts associated with encephalopathy: Long-term outcomes in 14 patients.2013

    • Author(s)
      Naeshiro N. Kakizawa H. Aikata H. Kan H. Fujino H. Fukuhara T. Kobayashi T. Honda Y. Miyaki D. Kawaoka T. Tsuge M. Hiramatsu A. Imamura M. Kawakami Y. Hyogo H. Ishikawa M. Awai K, and Chayama K
    • Journal Title

      Hepatol Res

      Volume: 電子書籍 Issue: 7 Pages: 740-749

    • DOI

      10.1111/hepr.12181

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383
  • [Journal Article] Utility of controlled attenuation parameter measurement for assessing liver steatosis in Japanese patients with chronic liver diseases.2013

    • Author(s)
      Masaki K. Takaki S. Hyogo H. Kobayashi T. Fukuhara T. Naeshiro N. Honda Y. Nakahara T. Ohno A. Miyaki D. Murakami E. Nagaoki Y. Kawaoka T. Tsuge M. Hiraga N. Hiramatsu A. Imamura M. Kawakami Y. Aikata H. Ochi H. Takahashi S. Arihiro K, and Chayama K
    • Journal Title

      Hepatol Res

      Volume: 43 Issue: 11 Pages: 1182-9

    • DOI

      10.1111/hepr.12094

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Journal Article] A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation2013

    • Author(s)
      Nakano Y, Makita N, (32人中31番目) et al
    • Journal Title

      PLOS Genet

      Volume: 9 Issue: 4 Pages: e1003364-e1003364

    • DOI

      10.1371/journal.pgen.1003364

    • NAID

      120006985866

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22136007, KAKENHI-PROJECT-23390209, KAKENHI-PROJECT-24390199, KAKENHI-PROJECT-24591086, KAKENHI-PROJECT-24591575, KAKENHI-PUBLICLY-25136727, KAKENHI-PROJECT-25640066, KAKENHI-PROJECT-25670369
  • [Journal Article] Response to "treatment guidelines for HCV genotype 1: mono for low, triple for high, and dual for 'middle'?".2013

    • Author(s)
      Chayama K. Hayes C N. Ohishi W, and Kawakami Y
    • Journal Title

      J Gastroenterol

      Volume: 48 Issue: 4 Pages: 557-8

    • DOI

      10.1007/s00535-013-0760-y

    • NAID

      10031169235

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Journal Article] Efficacy of probucol for the treatment of non-alcoholic steatohepatitis with dyslipidemia: An open-label pilot study.2013

    • Author(s)
      Ishitobi T. Hyogo H. Tokumo H. Arihiro K, and Chayama K
    • Journal Title

      Hepatol Res

      Volume: 電子書籍 Issue: 4 Pages: 429-435

    • DOI

      10.1111/hepr.12135

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Journal Article] Combining molecular targeted drugs to inhibit both cancer cells and activated stromal cells in gastric cancer2013

    • Author(s)
      Onoyama M, Kitadai Y, Tanaka Y, Yuge R, Shinagawa K, Tanaka S, Yasui W, and Chayama K
    • Journal Title

      Neoplasia

      Volume: 15 Issue: 12 Pages: 9-1391

    • DOI

      10.1593/neo.131668

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Journal Article] Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B.2013

    • Author(s)
      Arataki K, Hayes CN, Akamatsu S, Akiyama R, Abe H, Tsuge M, Miki D, Ochi H, Hiraga N, Imamura M, Takahashi S, Aikata H, Kawaoka T, Kawakami H, Ohishi W, Chayama K.
    • Journal Title

      Journal of Medical Virology

      Volume: 85(5) Issue: 5 Pages: 789-98

    • DOI

      10.1002/jmv.23540

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791023, KAKENHI-PROJECT-25670369
  • [Journal Article] Glycemic variability is an independent predictive factor for development of hepatic fibrosis in nonalcoholic Fatty liver disease.2013

    • Author(s)
      Hashiba M,Ono M,Okamoto N,Saibara T et.al
    • Journal Title

      PLoS One

      Volume: 8(11) Issue: 11 Pages: e76161-e76161

    • DOI

      10.1371/journal.pone.0076161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-25670369
  • [Journal Article] Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development2013

    • Author(s)
      Lange C M, Miki D, Ochi H, Nischalke H D, Bojunga J, Bibert S, Morikawa K, Gouttenoire J, Cerny A, Dufour J F, Gorgievski-Hrisoho M, Heim M H, Malinverni R, Mullhaupt B, Negro F, Semela D, Kutalik Z, Muller T, Spengler U, Berg T, Chayama K, Moradpour D, Bochud P Y, Hiroshima Liver Study G, and Swiss Hepatitis C C S G
    • Journal Title

      PLoS One

      Volume: 8 Issue: 5 Pages: e64053-e64053

    • DOI

      10.1371/journal.pone.0064053

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Journal Article] Clinical efficacy of combination therapy with ME3738 and pegylated interferon-alpha-2a in patients with hepatitis C virus genotype 1.2013

    • Author(s)
      Saibara T, Enomoto N, Kaneko S, Chayama K, Sata M, Imawari M, Onishi S, Okita K.
    • Journal Title

      Hepatol Res.

      Volume: Apr 19 Issue: 4 Pages: 410-419

    • DOI

      10.1111/hepr.12139

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390195, KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26461010, KAKENHI-PROJECT-26461011
  • [Journal Article] HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study.2013

    • Author(s)
      Miki D, Ochi H, Takahashi A, Hayes CN, Urabe Y, Abe H, Kawaoka T, Tsuge M, Hiraga N, Imamura M, Kawakami Y, Aikata H, Takahashi S, Akuta N, Suzuki F, Ikeda K, Kumada H, Karino Y, Toyota J, Tsunoda T, Kubo M, Kamatani N, Nakamura Y, Chayama K.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 12 Pages: e84226-e84226

    • DOI

      10.1371/journal.pone.0084226

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790701, KAKENHI-PROJECT-24790702, KAKENHI-PROJECT-25670369
  • [Journal Article] Dynamic computed tomography appearance of tumor response after stereotactic body radiation therapy for hepatocellular carcinoma: How should we evaluate treatment effects?2013

    • Author(s)
      Kimura T. Takahashi S. Kenjo M. Nishibuchi I. Takahashi I. Takeuchi Y. Doi Y. Kaneyasu Y. Murakami Y. Honda Y. Aikata H. Chayama K, and Nagata Y
    • Journal Title

      Hepatol Res

      Volume: 43 Issue: 7 Pages: 717-27

    • DOI

      10.1111/hepr.12007

    • NAID

      10031194575

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Journal Article] Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice2013

    • Author(s)
      Shi, N. Hiraga, N. Imamura, M. Hayes, C. N. Zhang, Y. Kosaka, K. Okazaki, A. Murakami, E. Tsuge, M. Abe, H. Aikata, H. Takahashi, S. Ochi, H. Tateno-Mukaidani, C. Yoshizato, K. Matsui, H. Kanai, A. Inaba, T. McPhee, F. Gao, M. Chayama, K.
    • Journal Title

      Gut

      Volume: 62 Issue: 7 Pages: 1055-1061

    • DOI

      10.1136/gutjnl-2012-302600

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591397, KAKENHI-PROJECT-24790702, KAKENHI-PROJECT-25670369, KAKENHI-PLANNED-22118005
  • [Journal Article] Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population2012

    • Author(s)
      Sumida Y, Yoneda M, Hyogo H, Itoh Y, Ono M, Fujii H, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Fujita K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T, Jsg-Nafld JS
    • Journal Title

      BMC Gastroenterol

      Volume: (Epub) Issue: 1 Pages: 2-2

    • DOI

      10.1186/1471-230x-12-2

    • NAID

      120005122663

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-21590849, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790660, KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-24659368
  • [Journal Article] Severe necroinflammatory reaction caused by natural killer by Fas/ FasL interaction and dendritic cells in human hepatocyte chimeric mouse2012

    • Author(s)
      Okazaki A, Hiraga N, Imamura M, NelsonHayes C, Tsuge M, Takahashi S, AikataH, Abe H, Miki D, Ochi H, Tateno C, Yoshizato K, Ohdan H, Chayama K
    • Journal Title

      Hepatology

      Volume: (in press) Issue: 2 Pages: 25651-25651

    • DOI

      10.1002/hep.25651

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790646, KAKENHI-PROJECT-24659368, KAKENHI-PROJECT-24791023
  • [Journal Article] IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients2012

    • Author(s)
      Ohnishi M, Tsuge M, Kohno T, Zhang Y, Abe H, Hyogo H, Kimura Y, Miki D, Hiraga N, Imamura M, Takahashi S, Ochi H, Hayes CN, Tanaka S, Arihiro K, Chayama K
    • Journal Title

      J Gastroenterol

      Volume: (in press) Issue: 7 Pages: 834-844

    • DOI

      10.1007/s00535-012-0550-y

    • NAID

      10030962375

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24659368
  • [Journal Article] Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, inhepatitis C virus genotype1b-infected null responders2012

    • Author(s)
      Chayama K, Takahashi S, Toyota J, Karino Y, Ikeda K, Ishikawa H, Watanabe H, McPhee F, Hughes E, KumadaH
    • Journal Title

      Hepatology

      Volume: 55 Issue: 3 Pages: 742-748

    • DOI

      10.1002/hep.24724

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24659368
  • [Journal Article] Serum PAI-1 is a novel predictor for response to pegylated interferon-al pha-2b plus ribavirin therapy in chronic hepatitis C virus infection2012

    • Author(s)
      Miki D, Ohishi W, Ochi H, Hayes CN, Abe H, Tsuge M, Imamura M, Kamatani N, Nakamura Y, Chayama K
    • Journal Title

      J Viral Hepat

      Volume: 19 Issue: 2 Pages: 126-133

    • DOI

      10.1111/j.1365-2893.2011.01516.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790646, KAKENHI-PROJECT-23590840, KAKENHI-PROJECT-24659368
  • [Journal Article] Dual Oral Therapy with Daclatasvir and Asunaprevir for Patients with HCV Genotype 1b Infection and Limited Treatment Options2012

    • Author(s)
      Suzuki Y, Ikeda K, Suzuki F, Toyota J, Karino Y, Chayama K, et al
    • Journal Title

      J Hepatol

      Volume: 58 Issue: 4 Pages: 655-662

    • DOI

      10.1016/j.jhep.2012.09.037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659368, KAKENHI-PROJECT-25670369
  • [Journal Article] Impact of interleukin-28B genotype on in vitro and in vivo systems of hepatitis C virus replication2012

    • Author(s)
      Chayama K
    • Journal Title

      Hepatol Res

      Volume: 42 Issue: 9 Pages: 841-53

    • DOI

      10.1111/j.1872-034x.2012.01002.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590737, KAKENHI-PROJECT-24659368
  • [Journal Article] Characterization of virologic escape in hepatitis C virus genotype 1b patients treated with the direct-acting antivirals daclatasvir and asunaprevir2012

    • Author(s)
      Karino Y, Toyota J, Ikeda K, Suzuki F, Chayama K, Kawakami Y, et al
    • Journal Title

      J Hepatol

      Volume: 58 Issue: 4 Pages: 648-645

    • DOI

      10.1016/j.jhep.2012.11.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659368, KAKENHI-PROJECT-25670369
  • [Journal Article] Hepatocellular carcinoma : towards personalized medicine2012

    • Author(s)
      Miki D, Ochi H, Nelson Hayes C, Aikata H, Chayama K
    • Journal Title

      Cancer Sci

      Volume: (in press) Issue: 5 Pages: 846-850

    • DOI

      10.1111/j.1349-7006.2012.02242.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24659368
  • [Journal Article] Genetics of IL28B and HCV-response to infection and treatment2012

    • Author(s)
      Hayes CN
    • Journal Title

      Nat Rev Gastroenterol Hepato

      Volume: 9 Issue: 7 Pages: 406-17

    • DOI

      10.1038/nrgastro.2012.101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590737, KAKENHI-PROJECT-24659368
  • [Journal Article] Atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-alpha-lowering property2012

    • Author(s)
      Hyogo H, Yamagishi SI, Maeda S, Kimura Y, Ishitobi T, Chayama K
    • Journal Title

      Dig Liver Dis

      Volume: (in press) Issue: 6 Pages: 482-486

    • DOI

      10.1016/j.dld.2011.12.013

    • NAID

      120005308251

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24659368
  • [Journal Article] Toward the establishment of a prediction system for thepersonalized treatment of chronic hepatitis C2012

    • Author(s)
      Ochi H, Hayes CN, Abe H, Hayashida Y, Uchiyama T, Kamatani N, Nakamura Y, Chayama K
    • Journal Title

      J Infect Dis

      Volume: 205 Issue: 2 Pages: 204-210

    • DOI

      10.1093/infdis/jir726

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24659368
  • [Journal Article] Efficacy and safety of telaprevir, a new protease inhibitor, for difficult-to-treat patients with genotype 1 chronic hepatitis C2012

    • Author(s)
      Hayashi N, Okanoue T, Tsubouchi H, Toyota J, Chayama K, Kumada H
    • Journal Title

      J Viral Hepat

      Volume: 19 Issue: 2 Pages: 134-42

    • DOI

      10.1111/j.1365-2893.2011.01528.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24659368
  • [Journal Article] Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 inJapan2012

    • Author(s)
      Kumada H, Toyota J, Okanoue T, ChayamaK, Tsubouchi H, Hayashi N
    • Journal Title

      J Hepatol

      Volume: 56 Issue: 1 Pages: 78-84

    • DOI

      10.1016/j.jhep.2011.07.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24659368
  • [Journal Article] Treatment of chronic hepatitis C virus infection in Japan: update on therapy and guidelines2012

    • Author(s)
      Chayama K , Hayes CN, Ohishi W,Kawakami Y
    • Journal Title

      J Gastroenterol

      Volume: 48 Issue: 1 Pages: 1-12

    • DOI

      10.1007/s00535-012-0714-9

    • NAID

      10031145523

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659368, KAKENHI-PROJECT-25670369
  • [Journal Article] Impact of pegylated interferon therapy on outcomes of patients with hepatitis C virus-related hepatocellular carcinoma after curative hepatic resection2012

    • Author(s)
      Tanimoto Y, Tashiro H, Aikata H, Amano H, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Takahashi S, Itamoto T, Chayama K, Ohdan H
    • Journal Title

      Ann Surg Oncol

      Volume: 19 Issue: 2 Pages: 418-425

    • DOI

      10.1245/s10434-011-1866-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-21591748, KAKENHI-PROJECT-21791288, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24592001, KAKENHI-PROJECT-24659368
  • [Journal Article] Amino Acid Substitution in HCV Core/NS5A Region and Genetic Variati on Near IL28B Gene Affect Treatment Efficacy to Interferon plus Ribavirin Combination Therapy2012

    • Author(s)
      Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Chayama K, Nakamura Y, Kumada H
    • Journal Title

      Intervirology

      Volume: 55 Issue: 3 Pages: 231-41

    • DOI

      10.1159/000328327

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-21590866, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24659368
  • [Journal Article] Risk factors for the exacerbation of esophageal varices or portosystemic encephalopathy after sustained virological response with IFN therapy for HCV-related compensated cirrhosis2012

    • Author(s)
      Nagaoki Y, Aikata H, Kobayashi T, Fukuhara T, Masaki K, Tanaka M, et al
    • Journal Title

      J Gastroenterol

      Volume: 48 Issue: 7 Pages: 847-55

    • DOI

      10.1007/s00535-012-0679-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659368, KAKENHI-PROJECT-25670369
  • [Journal Article] Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan : a multicenter large retrospective study2012

    • Author(s)
      Eguchi Y, Hyogo H, Ono M, Mizuta T, Ono N, Fujimoto K, Chayama K, Saibara T, Jsg N
    • Journal Title

      J Gastroenterol

      Volume: (in press) Issue: 5 Pages: 586-595

    • DOI

      10.1007/s00535-012-0533-z

    • NAID

      10030650741

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-21590849, KAKENHI-PROJECT-22590741, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-23590979, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-24659368
  • [Journal Article] Combination of hepatitis B viral antigens and DNA for prediction of relapse after discontinuation of nucleos(t)ide analogs in patients with chronic hepatitis B2012

    • Author(s)
      Matsumoto A, Tanaka E, Suzuki Y, Kobayashi M, Tanaka Y, Shinkai N, Hige S, Yatsuhashi H, Nagaoka S, Chayama K, Tsuge M, Yokosuka O, Imazeki F, Nishiguchi S, Saito M, Fujiwara K, Torii N, Hiramatsu N, Karino Y, Kumada H
    • Journal Title

      Hepatol Res

      Volume: 42 Issue: 2 Pages: 139-149

    • DOI

      10.1111/j.1872-034x.2011.00910.x

    • NAID

      10031144221

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24659368
  • [Journal Article] Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor2012

    • Author(s)
      Sainz B, Jr., Barretto N, Martin DN, Hiraga N, Imamura M, Hussain S, Marsh KA, Yu X, Chayama K, Alrefai WA, Uprichard SL
    • Journal Title

      Nat Med

      Volume: 18 Issue: 2 Pages: 281-285

    • DOI

      10.1038/nm.2581

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24659368
  • [Journal Article] HCV replication animal model2011

    • Author(s)
      Imamura M, Hiraga N, Chayama K
    • Journal Title

      Nihon Rinsho

      Volume: 69 Suppl 4 Pages: 75-79

    • NAID

      40018838443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] Impact of radiation and hepatitis virus infection on risk of hepatocellular carcinoma2011

    • Author(s)
      Ohishi W, Fujiwara S, Cologne JB, Suzuki G, Akahoshi M, Nishi N, TsugeM, Chayama K
    • Journal Title

      Hepatology

      Volume: 53 Issue: 4 Pages: 1237-1245

    • DOI

      10.1002/hep.24207

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-23590840
  • [Journal Article] Clinical features and prognosis in patients with hepatocellular carcinom a that developed after hepatitis C virus eradication with interferon therapy2011

    • Author(s)
      Nagaoki Y, Aikata H, Miyaki D, Murakami E, Hashimoto Y, Katamura Y, Azakami T, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Chayama K
    • Journal Title

      J Gastroenterol

      Volume: 46 Issue: 6 Pages: 799-808

    • DOI

      10.1007/s00535-011-0384-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] IL-28B predicts response to chronic hepatitis Ctherapy-fine-mapping and replication study in Asian populations2011

    • Author(s)
      Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Imamura M, Hiraga N, Kawakami Y, Aimitsu S, Kao JH, Kubo M, Tsunoda T, Kumada H, Nakamura Y, HayesCN, Chayama K
    • Journal Title

      J Gen Virol

      Volume: 92 Issue: 5 Pages: 1071-1081

    • DOI

      10.1099/vir.0.029124-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PLANNED-22116010, KAKENHI-PROJECT-22659147
  • [Journal Article] A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population2011

    • Author(s)
      Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, Hosono N, Takahashi A, Kamatani Y, Miki D, Abe H, Tsunoda T, Kamatani N, Chayama K, Nakamura Y, Matsuda K
    • Journal Title

      Hum Mol Genet

      Volume: 20 Issue: 19 Pages: 3884-3892

    • DOI

      10.1093/hmg/ddr301

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-23651192
  • [Journal Article] A huge metastatic liver tumor from leiomyosarcoma of the inferior vena cava : report of a case2011

    • Author(s)
      Hashimoto M, Kobayashi T, Tashiro H, Amano H, Oshita A, Tanimoto Y, Kuroda S, Tazawa H, Aikata H, Chayama K, Fujii M, Arihiro K, Ohdan H
    • Journal Title

      Surg Today (Epub 30 Nov.)

      Volume: (Epub) Issue: 5 Pages: 505-508

    • DOI

      10.1007/s00595-011-0070-z

    • NAID

      10030621850

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-21591748, KAKENHI-PROJECT-21791288, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24592001
  • [Journal Article] Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b2011

    • Author(s)
      Hashimoto Y, Ochi H, Abe H, Hayashida Y, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Nelson Hayes C, Ohishi W, Kubo M, Tsunoda T, Kamatani N, Nakamura Y, Chayama K
    • Journal Title

      J Med Virol

      Volume: 83 Issue: 6 Pages: 981-988

    • DOI

      10.1002/jmv.22028

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790646
  • [Journal Article] IL28 variationaffects expression of interferonstimulated genes and peg-interferonand ribavirin the rapy2011

    • Author(s)
      Abe H, Hayes CN, Ochi H, Maekawa T, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Chayama K
    • Journal Title

      J Hepatol

      Volume: 54 Issue: 6 Pages: 1094-1101

    • DOI

      10.1016/j.jhep.2010.09.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PLANNED-22116010, KAKENHI-PROJECT-22659147
  • [Journal Article] Impact of viral aminoacid substitutions and hostinterleukin-28b polymorphism on replication and susceptibility tointerferon of hepatitis C virus2011

    • Author(s)
      Hiraga N, Abe H, Imamura M, Tsuge M, Takahashi S, Hayes CN, Ochi H, TatenoC, Yoshizato K, Nakamura Y, KamataniN, Chayama K
    • Journal Title

      Hepatology

      Volume: 54 Issue: 3 Pages: 764-711

    • DOI

      10.1002/hep.24453

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790646
  • [Journal Article] Significant regression of a cavernous hepatic hemangioma to a sclerosed hemangioma over 12 years :a case study2011

    • Author(s)
      Miyaki D, Aikata H, Waki K, Murakami E, Hashimoto Y, Nagaoki Y, Katamura Y, Kawaoka T, Takaki S, Hiramatsu A, Imamura M, Takahashi S, Ohya T, Sakimoto H, Arihiro K, Chayama K
    • Journal Title

      Nihon Shokakibyo Gakkai Zasshi

      Volume: 108 Pages: 954-961

    • NAID

      10031122114

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice2011

    • Author(s)
      Ohara E, Hiraga N, Imamura M, Iwao E, Kamiya N, Yamada I, Kono T, Onishi M, Hirata D, Mitsui F, Kawaoka T, TsugeM, Takahashi S, Abe H, Hayes CN, OchiH, Tateno C, Yoshizato K, Tanaka S, Chayama K
    • Journal Title

      JHepatol

      Volume: 54 Issue: 5 Pages: 872-878

    • DOI

      10.1016/j.jhep.2010.08.033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers2011

    • Author(s)
      Miki D, Ochi H, Hayes CN, Abe H, Yoshima T, Aikata H, Ikeda K, KumadaH, Toyota J, Morizono T, Tsunoda T, Kubo M, Nakamura Y, Kamatani N, Chayama K
    • Journal Title

      Nat Genet

      Volume: 43 Issue: 8 Pages: 797-800

    • DOI

      10.1038/ng.876

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PLANNED-22116010, KAKENHI-PLANNED-22134008, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790646, KAKENHI-PROJECT-221S0001
  • [Journal Article] Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses2011

    • Author(s)
      Wakita T, Suzuki T, Evans MJ, Shimotohno K, Chayama K, Matsuura Y, Hijikata M, Moriishi K, Seya T, Enomoto N, Koike K, Kato N, Kanto T, Hotta H
    • Journal Title

      Gastroenterology

      Volume: 141 Issue: 1 Pages: 1-5

    • DOI

      10.1053/j.gastro.2011.05.027

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23390195
  • [Journal Article] Recent trend of clinical features in patients with hepatocellular carcinoma2011

    • Author(s)
      Nagaoki Y, Hyogo H, Aikata H, Tanaka M, Naeshiro N, Nakahara T, Honda Y, Miyaki D, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Chayama K
    • Journal Title

      Hepatol Res (Epub 13 Dec.)

      Volume: (Epub) Issue: 4 Pages: 368-375

    • DOI

      10.1111/j.1872-034x.2011.00929.x

    • NAID

      10031144249

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24659368
  • [Journal Article] In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis2011

    • Author(s)
      Saeed M, Shiina M, Date T, Akazawa D, Watanabe N, Murayama A, Suzuki T, Watanabe H, Hiraga N, Imamura M, Chayama K, Choi Y, Krawczynski K, Liang TJ, Wakita T, Kato T
    • Journal Title

      Hepatology

      Volume: 54 Issue: 2 Pages: 425-433

    • DOI

      10.1002/hep.24399

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22590713, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-23659407, KAKENHI-PROJECT-23790513
  • [Journal Article] Prevention of hepatitis B virus reactivation in immunosuppressive therapy or chemotherapy2011

    • Author(s)
      Ohishi W, Chayama K
    • Journal Title

      Clin Exp Nephrol

      Volume: 15 Issue: 5 Pages: 634-640

    • DOI

      10.1007/s10157-011-0464-7

    • NAID

      10030340714

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-23590840
  • [Journal Article] Platelet count for predicting fibrosis in nonalcoholic fatty liver disease2011

    • Author(s)
      Yoneda M, Fujii H, Sumida Y, Hyogo H, Itoh Y, Ono M, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Imajo K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T, Japan Study Group of Nonal coholic Fatty Liver D
    • Journal Title

      J Gastroenterol

      Volume: 46 Issue: 11 Pages: 1300-1306

    • DOI

      10.1007/s00535-011-0436-4

    • NAID

      10030294888

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-21590849, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790660, KAKENHI-PROJECT-23590979
  • [Journal Article] Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice2011

    • Author(s)
      Tsuge M, Takahashi S, Hiraga N, Fujimoto Y, Zhang Y, Mitsui F, Abe H, Kawaoka T, Imamura M, Ochi H, Hayes CN, Chayama K
    • Journal Title

      J Infect Dis

      Volume: 204 Issue: 2 Pages: 224-228

    • DOI

      10.1093/infdis/jir247

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] IL28B butnot ITPA polymorphism is predictive ofresponse to pegylated interferon, ribavirin, and telaprevir tripletherapy in patients with genotype 1hepatitis C2011

    • Author(s)
      Chayama K, Hayes CN, Abe H, Miki D, Ochi H, Karino Y, Toyota J, NakamuraY, Kamatani N, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H
    • Journal Title

      J Infect Dis

      Volume: 204 Issue: 1 Pages: 84-93

    • DOI

      10.1093/infdis/jir210

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Treatment strategy for early hepatocellular carcinomas : comparison of radiofrequency ablation with or without transcatheter arterial chemoembolization and surgical resection2011

    • Author(s)
      Tashiro H, Aikata H, Waki K, Amano H, Oshita A, Kobayashi T, Tanimoto Y, Kuroda S, Tazawa H, Chayama K, Asahara T, Ohdan H
    • Journal Title

      J Surg Oncol

      Volume: 104 Issue: 1 Pages: 3-9

    • DOI

      10.1002/jso.21745

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-21791288, KAKENHI-PROJECT-22659147
  • [Journal Article] A single nucleotidepoly morphism in activated Cdc42 associated tyrosine kinase 1influences the interferon therapy in hepatitis C patients2011

    • Author(s)
      Fujimoto Y, Ochi H, Maekawa T, Abe H, Hayes CN, Kumada H, Nakamura Y, Chayama K
    • Journal Title

      J Hepatol

      Volume: 54 Issue: 4 Pages: 629-639

    • DOI

      10.1016/j.jhep.2010.07.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Clinical outcome of esophageal varices after hepatic arterial infusion chemotlierapy for advanced hepatocellular carcinoma with major portal vein tumor thrombus2011

    • Author(s)
      Kodama H, Aikata H, Murakami E, Miyaki D, Nagaoki Y, Hashimoto Y, Azakami T, Katamura Y, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Ishikawa M, Kakizawa H, Awai K, Kenio M, Nagata Y, Chayama K
    • Journal Title

      Hepatol Res

      Volume: 41 Issue: 11 Pages: 1046-1056

    • DOI

      10.1111/j.1872-034x.2011.00857.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Hepatitis C virus infectionsuppresses the interferon response inthe liver of the human hepatocytechimeric mouse2011

    • Author(s)
      Tsuge M, Fujimoto Y, Hiraga N, ZhangY, Ohnishi M, Kohno T, Abe H, Miki D, Imamura M, Takahashi S, Ochi H, HayesCN, Miya F, Tsunoda T, Chayama K
    • Journal Title

      PLoS One

      Volume: 6 Issue: 8 Pages: 23856-23856

    • DOI

      10.1371/journal.pone.0023856

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] ME3738 enhances the effect of interferon andinhibits hepatitis C virusreplication both in vitro and in vivo2011

    • Author(s)
      Abe H, Imamura M, Hiraga N, Tsuge M, Mitsui F, Kawaoka T, Takahashi S, OchiH, Maekawa T, Hayes CN, Tateno C, Yoshizato K, Murakami S, Yamashita N, Matsuhira T, Asai K, Chayama K
    • Journal Title

      J Hepatol

      Volume: 55 Issue: 1 Pages: 11-18

    • DOI

      10.1016/j.jhep.2010.10.017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22590737, KAKENHI-PROJECT-22659147
  • [Journal Article] Impact of ribavirin dose reduction on the efficacy of pegylated interferon plus ribavirin combination therapy for elderly patients infected with genotype 1b and high viral loads2011

    • Author(s)
      Kohno H, Kouno H, Aimitsu S, Aisaka Y, Kitamoto M, Kawakami H, Chayama K
    • Journal Title

      Hepatol Ees

      Volume: 41 Issue: 7 Pages: 626-634

    • DOI

      10.1111/j.1872-034x.2011.00811.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis2011

    • Author(s)
      Yoshida K, Ohishi W, Nakashima E, Fujiwara S, Akahoshi M, Kasagi F, Chayama K, Hakoda M, Kyoizumi S, Nakachi K, Hayashi T, Kusunoki Y
    • Journal Title

      Hum Immunol

      Volume: 72 Issue: 10 Pages: 821-826

    • DOI

      10.1016/j.humimm.2011.05.029

    • NAID

      120006547414

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390199, KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-23590840
  • [Journal Article] Antiviral effects of peginterferon alpha-2b and ribavirin following 24-week monotherapy of telaprevir in Japanese hepatitis C patients2011

    • Author(s)
      Ozeki I, Akaike J, Karino Y, Arakawa T, Kuwata Y, Ohmura T, Sato T, Kamiya N, Yamada I, Chayama K, Kumada H, Toyota J
    • Journal Title

      J Gastroenterol

      Volume: 46 Issue: 7 Pages: 929-937

    • DOI

      10.1007/s00535-011-0411-0

    • NAID

      10029313367

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b2011

    • Author(s)
      Kawaoka T, Hayes CN, Ohishi W, Ochi H, Maekawa T, Abe H, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, KuboM, Tsunoda T, Nakamura Y, Kumada H, Chayama K
    • Journal Title

      J Hepatol

      Volume: 54 Issue: 3 Pages: 408-414

    • DOI

      10.1016/j.jhep.2010.07.032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Rapidemergence of telaprevir resistanthepatitis C virus strain from wildtypeclone in vivo2011

    • Author(s)
      Hiraga N, Imamura M, Abe H, Hayes CN, Kono T, Onishi M, Tsuge M, TakahashiS, Ochi H, Iwao E, Kamiya N, Yamada I, Tateno C, Yoshizato K, Matsui H, KanaiA, Inaba T, Tanaka S, Chayama K
    • Journal Title

      Hepatology

      Volume: 54 Issue: 3 Pages: 781-788

    • DOI

      10.1002/hep.24460

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PLANNED-22118005, KAKENHI-PROJECT-22590737, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22659181, KAKENHI-PROJECT-22790646, KAKENHI-PROJECT-22790912, KAKENHI-PROJECT-23390253
  • [Journal Article] Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir2011

    • Author(s)
      Suzuki F, Suzuki Y, Akuta N, Sezaki H, Hirakawa M, Kawamura Y, Hosaka T, Kobayashi M, Saito S, Arase Y, IkedaK, Kobayashi M, Chayama K, Kamatani N, Nakamura Y, Miyakawa Y, Kumada H
    • Journal Title

      Hepatology

      Volume: 53 Issue: 2 Pages: 415-421

    • DOI

      10.1002/hep.24058

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Achievement of Sustained Viral Response after Switching Treatment from Pegylated Interferon alpha-2b to alpha-2a and Ribavirin in Patients with Recurrence of Hepatitis C Virus Genotype 1 Infection after Liver Transplantation : A Case Report2011

    • Author(s)
      Kawaoka T, Hiraga N, Takahashi S, Takaki S, Tsuge M, Nagaoki Y, Hashimoto Y, Katamura Y, Muki D, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Aikata H, Ochi H, Tashiro H, Ohdan H, Chayama K
    • Journal Title

      Intervirology (Elpub 25 Aug.)

      Volume: (Epub) Issue: 4 Pages: 306-310

    • DOI

      10.1159/000328661

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-21591748, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24659368
  • [Journal Article] Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy2011

    • Author(s)
      Azakami T, Hayes CN, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Nakamura Y, Kamatani N, Chayama K
    • Journal Title

      J Med Virol

      Volume: 83 Issue: 6 Pages: 1048-1057

    • DOI

      10.1002/jmv.22069

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790646
  • [Journal Article] IL28B polymorphism may guide pegylated interferon plus ribavirin therapy even after curative treatment for hepatitis C virus-related hepatooellular carcinoma2011

    • Author(s)
      Kawaoka T, Aikata H, Takaki S, Hiramatsu A, Waki K, Hiraga N, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Tashiro H, Ohdan H, Chayama K
    • Journal Title

      J Viral Hepat

      Volume: 18 Issue: 10 Pages: e550-e560

    • DOI

      10.1111/j.1365-2893.2011.01468.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-21591748, KAKENHI-PROJECT-22659147
  • [Journal Article] Treatment of chronic hepatitis B with nuoleos(t)ide analogues2011

    • Author(s)
      Ohishi W, Chayama K
    • Journal Title

      Hepatol Ees

      Volume: 42 Issue: 3 Pages: 219-25

    • DOI

      10.1111/j.1872-034x.2011.00921.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-23590840, KAKENHI-PROJECT-24659368
  • [Journal Article] Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state2011

    • Author(s)
      Abe H, Hayes CN, Ochi H, Tsuge M, Miki D, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Kamatani N, Chayama K
    • Journal Title

      J Med Virol

      Volume: 83 Issue: 9 Pages: 1597-1607

    • DOI

      10.1002/jmv.22158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PLANNED-22116010, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22790646
  • [Journal Article] HCV replication animal model2011

    • Author(s)
      Imamura M, Hiraga N, Chayama K
    • Journal Title

      Nihon Rinsho

      Volume: 69 Suppl 4 Pages: 75-79

    • NAID

      40018838443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Significant regression of a cavernous hepatic hemangioma to a sclerosed hemangioma over 12 years : a case study2011

    • Author(s)
      Mlyaki D, Aikata H, Waki K, Murakami E, Hashimoto Y, Nagaoki Y, Katamura Y, Kawaoka T, Takaki S, Hiramatsu A, Imamura M, Takahashi S, Ohya T, Sakimoto H, Arihiro K, Chayama K
    • Journal Title

      Nihon Shokakibyo Gakkai Zasshi

      Volume: 108 Pages: 954-961

    • NAID

      10031122114

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] A randomized phase II trial of intra-arterial chemotherapy using SM-11355 (Miriplatin) for hepatocellular carcinoma2011

    • Author(s)
      Okusaka T, Kasugai H, Ishii H, Kudo M, Sata M, Tanaka K, Shioyama Y, Chayama K, Kumada H, Yoshikawa M, Seki T, Saito H, Hayashi N, Shiratori K, Okita K, Sakaida I, Honda M, Kusumoto Y, Tsutsumi T, Sakata K
    • Journal Title

      Invest New Drugs (Epub 21 Dec.)

      Volume: (E-pub) Issue: 5 Pages: 2015-2025

    • DOI

      10.1007/s10637-011-9776-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-24390187
  • [Journal Article] Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C2011

    • Author(s)
      Chayama K, Hayes CN, Yoshioka K, Moriwaki H, Okanoue T, Sakisaka S, Takehara T, Oketani M, Toyota J, Izumi N, Hiasa Y, Matsumoto A, Nomura H, Seike M, Ueno Y, Yotsuyanagi H, Kumada H
    • Journal Title

      J Gastroenterol

      Volume: 46 Issue: 4 Pages: 545-555

    • DOI

      10.1007/s00535-010-0358-6

    • NAID

      10029028821

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Cutaneous complications after transcatheter arterial treatment for hepat ocellular carcinoma via the internal mammary artery : how to avoid this complication2011

    • Author(s)
      Kajiwara K, Kakizawa H, Takeuchi N, Toyota N, Hieda M, Ishikawa M, Tanitame K, Tani G, Suzuki T, Fujikawa K, Aikata H, Chayama K, Awai K
    • Journal Title

      Jpn J Radiol

      Volume: 29 Issue: 5 Pages: 307-315

    • DOI

      10.1007/s11604-011-0559-9

    • NAID

      50008099049

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] HCV substitutions and IL28B polymorphisms on outcome ofpeg-interferon plus ribavirincombination therapy2011

    • Author(s)
      Hayes CN, Kobayashi M, Akuta N, SuzukiF, Kumada H, Abe H, Miki D, Imamura M, Ochi H, Kamatani N, Nakamura Y, Chayama K
    • Journal Title

      Gut

      Volume: 60 Issue: 2 Pages: 261-267

    • DOI

      10.1136/gut.2010.223495

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Eradication of hepatitis C virus genotype 1 after liver transplantation by interferon therapy before surgery : Report of three patients with analysis of interleukin-28 polymorphism, hepatitis C virus core region and interferon-sensitivity determining region2011

    • Author(s)
      Kawaoka T, Aikata H, Miyaki D, Murakami E, Azakami T, Takaki S, Nagaoki Y, Hashimoto Y, Katamura Y, Hiramatsu A, Waki K, Hiraga N, Miki D, TsugeM, Imamura M, Kawakami Y, Takahashi S, Ochi H, Tashiro H, Ohdan H, Chayama K
    • Journal Title

      Hepatol Res

      Volume: 41 Issue: 11 Pages: 1126-1131

    • DOI

      10.1111/j.1872-034x.2011.00853.x

    • NAID

      10031144190

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-21591748, KAKENHI-PROJECT-22659147
  • [Journal Article] IL-6-mediated intersubgenotypic variation of interfer on sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2010

    • Author(s)
      Suda G, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M.
    • Journal Title

      Virology.

      Volume: 407(1) Pages: 80-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] Prolongation of interferon therapy for recurrent hepatitis C after living donor liver transplantation : analysis of predictive factors of sustained virological response, including amino acid sequence of the core and NS5A regions of hepatitis C virus2010

    • Author(s)
      Kawaoka T, Hiraga N, Takahashi S, Takaki S, Mitsui F, Tsuge M, Nagaoki Y, Kimura Y, Hashimoto Y, Katamura Y, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Aikata H, Tashiro H, Ohdan H., Chayama K.
    • Journal Title

      Scand J Gastroenterol

      Volume: 45(12) Pages: 1488-1496

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients.2010

    • Author(s)
      Abe H, Ochi H, Maekawa T, Hayes CN, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Ohishi W, Arihiro K, Kubo M, Nakamura Y, Chayama K.
    • Journal Title

      J Hepatol.

      Volume: 53(3) Pages: 439-443

    • NAID

      120002577227

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] Amino acid substitutions in core and NS5A regions of the HCV genome can predict virological decrease with pegylated interferon plus ribavirin therapy.2010

    • Author(s)
      Kitamura S, Tsuge M, Hatakeyama T, Abe H, Imamura M, Mori N, Saneto H, Kawaoka T, Mitsui F, Hiraga N, Takaki S, Kawakami Y, Aikata H, Takahashi S, Ohishi W, Ochi H, Hayes CN, Chayama K
    • Journal Title

      Antivir Ther

      Volume: 15(8) Pages: 1087-1097

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] ITPA Polymorphism Affects Ribavirin-induced Anemia and Outcome of Therapy-a Genome-wide Study of Japanese HCV Patients.2010

    • Author(s)
      Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Kubo M, Tsunoda T, Hayes CN, Kumada H, Nakamura Y, Chayama K
    • Journal Title

      Gastroenterology.

      Volume: 139(4) Pages: 1190-1197

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginter feron and ribavirin.2010

    • Author(s)
      Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Chayama K, Nakamura Y, Kumada H.
    • Journal Title

      Hepatology

      Volume: 52(2) Pages: 421-429

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants.2010

    • Author(s)
      Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M
    • Journal Title

      Virology.

      Volume: 30;405(2) Pages: 361-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients2010

    • Author(s)
      Abe H, Ochi H, Maekawa T, Hayes CN, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Ohishi W, Arihiro K, Kubo M, Nakamura Y, ChayamaK
    • Journal Title

      J Hepatol

      Volume: 53 Issue: 3 Pages: 439-443

    • DOI

      10.1016/j.jhep.2010.03.022

    • NAID

      120002577227

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Long-term use of entecavir in nucleoside-naive Japanese patients with chronic hepatitis B infection.2010

    • Author(s)
      Yokosuka O, Takaguchi K, Fujioka S, Shindo M, Chayama K, Kobashi H, Hayashi N, Sato C, Kiyosawa K, Tanikawa K, Ishikawa H, Masaki N, Seriu T, Omata M.
    • Journal Title

      J Hepatol

      Volume: 52(6) Pages: 791-799

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] ITPA Polymorphism Affects Ribavirin-induced Anemia and Outcome of Therapy-a Genome-wide Study of Japanese HCV Patients.2010

    • Author(s)
      Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Kubo M, Tsunoda T, Hayes CN, Kumada H, Nakamura Y, Chayama K
    • Journal Title

      Gastroenterology.

      Volume: 139(4) Pages: 1190-1197

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] G to A hypermutation of TT virus.2010

    • Author(s)
      Tsuge M, Noguchi C, Akiyama R, Matsushita M, Kunihiro K, Tanaka S, Abe H, Mitsui F, Kitamura S, Hatakeyama T, Kimura T, Miki D, Hiraga N, Imamura M, Takahashi S, Hayses CN, Chayama K
    • Journal Title

      Virus Res

      Volume: 149(2) Pages: 211-216

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients.2010

    • Author(s)
      Abe H, Ochi H, Maekawa T, Hayes CN, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Ohishi W, Arihiro K, Kubo M, Nakamura Y, Chayama K.
    • Journal Title

      J Hepatol.

      Volume: 53(3) Pages: 439-443

    • NAID

      120002577227

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Amino acid substitutions in core and NS5A regions of the HCV genome can predict virological decrease with pegylated interferon plus ribavirin therapy.2010

    • Author(s)
      Kitamura S, Tsuge M, Hatakeyama T, Abe H, Imamura M, Mori N, Saneto H, Kawaoka T, Mitsui F, Hiraga N, Takaki S, Kawakami Y, Aikata H, Takahashi S, Ohishi W, Ochi H, Hayes CN, Chayama K
    • Journal Title

      Antivir Ther

      Volume: 15(8) Pages: 1087-1097

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy.2010

    • Author(s)
      Hayes CN, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Imamura M, Ochi H, Kamatani N, Nakamura Y, Chayama K.
    • Journal Title

      Gut

      Volume: 60(2) Pages: 261-267

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin.2010

    • Author(s)
      Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Chayama K, Nakamura Y, Kumada H.
    • Journal Title

      Hepatology

      Volume: 52(2) Pages: 421-429

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy.2010

    • Author(s)
      Hayes CN, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Imamura M, Ochi H, Kamatani N, Nakamura Y, Chayama K.
    • Journal Title

      Gut

      Volume: 60(2) Pages: 261-267

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] Amino acidsubstitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin2010

    • Author(s)
      Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Chayama K, Nakamura Y, Kumada H
    • Journal Title

      Hepatology

      Volume: 52 Issue: 2 Pages: 421-4293

    • DOI

      10.1002/hep.23690

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.2010

    • Author(s)
      Kawaoka T, Hayes CN, Ohishi W, Ochi H, Maekawa T, Abe H, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Tsunoda T, Nakamura Y, Kumada H, Chayama K
    • Journal Title

      J Hepatol

      Volume: 54(3) Pages: 408-414

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/ 2b chimeric clones2010

    • Author(s)
      Suda G, Sakamoto N, Itsui Y, NakagawaM, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M
    • Journal Title

      Virology

      Volume: 407 Issue: 1 Pages: 80-90

    • DOI

      10.1016/j.virol.2010.07.041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Differential effects of interferon and lamivudine on serum HBV RNA inhibition in patients with chronic hepatitis B.2010

    • Author(s)
      Huang YW, Chayama K, Tsuge M, Takahashi S, Hatakeyama T, Abe H, Hu JT, Liu CJ, Lai MY, Chen DS, Yang SS, Kao JH.
    • Journal Title

      Antivir Ther

      Volume: 15(2) Pages: 177-184

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] Cellculture and in vivo analyses of cytopathic hepatitis C virus mutants2010

    • Author(s)
      Mishima K, Sakamoto N, Sekine-OsajimaY, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M
    • Journal Title

      Virology

      Volume: 405 Issue: 2 Pages: 361-369

    • DOI

      10.1016/j.virol.2010.06.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan.2010

    • Author(s)
      Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y ; The Study Group for the Standardization of Treatment of Viral Hepatitis Including Cirrhosis, inistry of Health, Labor, Welfare of Japan.
    • Journal Title

      Hepatol Res

      Volume: 40(1) Pages: 1-7

    • NAID

      10027406161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C2010

    • Author(s)
      Chayama K, Hayes CN, Yoshioka K, Moriwaki H, Okanoue T, Sakisaka S, Takehara T, Oketani M, Toyota J, Izumi N, Hiasa Y, Matsumoto A, Nomura H, Seike M, Ueno Y, Yotsuyanagi H, Kumada H.
    • Journal Title

      Hepatol Res.

      Volume: 12 Pages: 1155-1167

    • NAID

      10028172403

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan.2010

    • Author(s)
      Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y ; The Study Group for the Standardization of Treatment of Viral Hepatitis Including Cirrhosis, Ministry of Health, Labor, Welfare of Japan.
    • Journal Title

      Hepatol Res

      Volume: 40(1) Pages: 1-7

    • NAID

      10027406161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] G to A hypermutation of TT virus.2010

    • Author(s)
      Tsuge M, Noguchi C, Akiyama R, Matsushita M, Kunihiro K, Tanaka S, Abe H, Mitsui F, Kitamura S, Hatakeyama T, Kimura T, Miki D, Hiraga N, Imamura M, Takahashi S, Hayses CN, Chayama K
    • Journal Title

      Virus Res

      Volume: 149(2) Pages: 211-216

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.2010

    • Author(s)
      Kawaoka T, Hayes CN, Ohishi W, Ochi H, Maekawa T, Abe H, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Tsunoda T, Nakamura Y, Kumada H, Chayama K.
    • Journal Title

      J Hepatol

      Volume: 54(3) Pages: 408-414

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy-a genome-wide study ofJapanese HCV virus patients2010

    • Author(s)
      Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Kubo M, Tsunoda T, Hayes CN, Kumada H, Nakamura Y, Chayama K
    • Journal Title

      Gastroenterology

      Volume: 139 Issue: 4 Pages: 1190-1197

    • DOI

      10.1053/j.gastro.2010.06.071

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants.2010

    • Author(s)
      Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M
    • Journal Title

      Virology.

      Volume: 30;405(2) Pages: 361-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B.2010

    • Author(s)
      Mitsui F, Tsuge M, Kimura T, Kitamura S, Abe H, Saneto H, Kawaoka T, Miki D, Hatakeyama T, Hiraga N, Imamura M, Kawakami Y, Aikata H, Takahashi S, Hayes CN, Igarashi H, Morimoto K, Shimizu M, Chayama K.
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 54(8) Pages: 3205-3211

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C2010

    • Author(s)
      Chayama K, Hayes CN, Yoshioka K, Moriwaki H, Okanoue T, Sakisaka S, Takehara T, Oketani M, Toyota J, Izumi N, Hiasa Y, Matsumoto A, Nomura H, Seike M, Ueno Y, Yotsuyanagi H, Kumada H.
    • Journal Title

      Hepatol Res.

      Volume: 12 Pages: 1155-1167

    • NAID

      10028172403

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B.2010

    • Author(s)
      Mitsui F, Tsuge M, Kimura T, Kitamura S, Abe H, Saneto H, Kawaoka T, Miki D, Hatakeyama T, Hiraga N, Imamura M, Kawakami Y, Aikata H, Takahashi S, Hayes CN, Igarashi H, Morimoto K, Shimizu M, Chayama K.
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 54(8) Pages: 3205-3211

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] IL-6-mediated intersubgenotypic variation of interfer on sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2010

    • Author(s)
      Suda G, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M.
    • Journal Title

      Virology.

      Volume: 407(1) Pages: 80-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Differential effects of interferon and lamivudine on serum HBV RNA inhibition in patients with chronic hepatitis B.2010

    • Author(s)
      Huang YW, Chayama K, Tsuge M, Takahashi S, Hatakeyama T, Abe H, Hu JT, Liu CJ, Lai MY, Chen DS, Yang SS, Kao JH.
    • Journal Title

      Antivir Ther

      Volume: 15(2) Pages: 177-184

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Prolongation of interferon therapy for recurrent hepatitis C after living donor liver transplantation : analysis of predictive factors of sustained virological response, including amino acid sequence of the core and NS5A regions of hepatitis C virus2010

    • Author(s)
      Kawaoka T, Hiraga N, Takahashi S, Takaki S, Mitsui F, Tsuge M, Nagaoki Y, Kimura Y, Hashimoto Y, Katamura Y, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Aikata H, Tashiro H, Ohdan H, Chayama K.
    • Journal Title

      Scand J Gastroenterol

      Volume: 45(12) Pages: 1488-1496

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] HBx protein is indispensable for development of viremia in human hepatocyte chimeric mice.2010

    • Author(s)
      Tsuge M, Hiraga N, Akiyama R, Tanaka S, Matsushita M, Mitsui F, Abe H, Kitamura S, Hatakeyama T, Kimura T, Miki D, Mori N, Imamura M, Takahashi S, Hayes CN, Chayama K.
    • Journal Title

      J Gen Virol

      Volume: 91(pt7) Pages: 1854-1864

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] HBx protein is indispensable for development of viraemia in human hepatocyte chimericmice2010

    • Author(s)
      Tsuge M, Hiraga N, Akiyama R, TanakaS, Matsushita M, Mitsui F, Abe H, Kitamura S, Hatakeyama T, Kimura T, Miki D, Mori N, Imamura M, TakahashiS, Hayes CN, Chayama K
    • Journal Title

      J Gen Virol

      Volume: 91 Issue: 7 Pages: 1854-1864

    • DOI

      10.1099/vir.0.019224-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Practical Evaluation of a Mouse with Chimeric Human Liver Model for Hepatitis C Virus Infection Using an NS3-4A Protease Inhibitor.2010

    • Author(s)
      Kamiya N, Iwao E, Hiraga N, Tsuge M, Imamura M, Takahashi S, Miyoshi S, Tateno C, Yoshizato K, Chayama K.
    • Journal Title

      J Gen Virol

      Volume: 91 Pages: 1668-1677

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor2010

    • Author(s)
      Kamiya N, Iwao E, Hiraga N, Tsuge M, Imamura M, Takahashi S, Miyoshi S, Tateno C, Yoshizato K, Chayama K
    • Journal Title

      J Gen Virol

      Volume: 91 Issue: 7 Pages: 1668-1677

    • DOI

      10.1099/vir.0.019315-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] HBx protein is indispensable for development of viremia in human hepatocyte chimeric mice.2010

    • Author(s)
      Tsuge M, Hiraga N, Akiyama R, Tanaka S, Matsushita M, Mitsui F, Abe H, Kitamura S, Hatakeyama T, Kimura T, Miki D, Mori N, Imamura M, Takahashi S, Hayes CN, Chayama K.
    • Journal Title

      J Gen Virol

      Volume: 91(pt7) Pages: 1854-1864

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Journal Article] Long-term use of entecavir in nucleoside-naive Japanese patients with chronic hepatitis B infection.2010

    • Author(s)
      Yokosuka O, Takaguchi K, Fujioka S, Shindo M, Chayama K, Kobashi H, Hayashi N, Sato C, Kiyosawa K, Tanikawa K, Ishikawa H, Masaki N, Seriu T, Omata M.
    • Journal Title

      J Hepatol

      Volume: 52(6) Pages: 791-799

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Practical Evaluation of a Mouse with Chimeric Human Liver Model for Hepatitis C Virus Infection Using an NS3-4A Protease Inhibitor.2010

    • Author(s)
      Kamiya N, Iwao E, Hiraga N, Tsuge M, Imamura M, Takahashi S, Miyoshi S, Tateno C, Yoshizato K, Chayama K.
    • Journal Title

      J Gen Virol

      Volume: 91 Pages: 1668-1677

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Long-term use ofentecavir in nucleoside-naiveJapanese patients with chronichepatitis B infection2010

    • Author(s)
      Yokosuka O, Takaguchi K, Fujioka S, Shindo M, Chayama K, Kobashi H, Hayashi N, Sato C, Kiyosawa K, Tanikawa K, Ishikawa H, Masaki N, Seriu T, Omata M
    • Journal Title

      J Hepatol

      Volume: 52 Issue: 6 Pages: 791-799

    • DOI

      10.1016/j.jhep.2009.12.036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22659147
  • [Journal Article] Predicting the response to 48-week combination therapy with peginterferon alpha-2b plus ribavirin from the estimated HCV RNA load index after negative serum change in genotype 1b hepatitis C patients2009

    • Author(s)
      Tsuji K, Kawakami Y, Aimitsu S, Kohno H, Aisaka Y, Kimura S, Nagata S, Ohgoshi H, Kitamoto M, Hidaka T, Kawakami H, Nakanishi T, Chayama K.
    • Journal Title

      Hepatol Res. 39(6)

      Pages: 531-538

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] G-to-A hypermutation in hepatitis B virus(HBV) and clinical course of patients with chronic HBV infection2009

    • Author(s)
      Noguchi C, Imamura M, Tsuge M, HiragaN, Mori N, Miki D, Kimura T, TakahashiS, Fujimoto Y, Ochi H, Abe H, MaekawaT, Tateno C, Yoshizato K, Chayama K
    • Journal Title

      J Infect Dis

      Volume: 199 Issue: 11 Pages: 1599-1607

    • DOI

      10.1086/598951

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Deletion of angiotensin II type I receptor reduces hepatic steatosis2009

    • Author(s)
      Nabeshima Y, Tazuma S, Kanno K, Hyogo H.Chayama K.
    • Journal Title

      J Hepatol 50(6)

      Pages: 1226-1235

    • NAID

      120001700483

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] A genome-wide association study identifies variants in the HLA-DP Iocus associated with chronic hepatitis B in Asians2009

    • Author(s)
      Kamatani Y, Wattanapokayakit S, Ochi H, Kawaguchi T, Takahashi A, Hosono N, Kubo M, Tsunoda T, Kamatani N, Kumada H, Puseenam A, Sura T, Daigo Y, Chayama K, Chantratita W, Nakamura Y, Matsuda K.
    • Journal Title

      Nat Ganet 41(5)

      Pages: 591-595

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice2009

    • Author(s)
      Abe H, Ochi H, Maekawa T, Hatakeyama T, Tsuge M, Kitamura S, Kimura T, Miki D, Mitsui F, Hiraga N, Imamura M, Fujimoto Y, Takahashi S, Nakamura Y, Kumada H, Chayama K.
    • Journal Title

      Hepatol Res 39

      Pages: 1159-1168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Intra-arterial 5-fluorouracil/interferon combination therapy for advanced hepatocellular carcinoma with or without three-dimensional conformal radiotherapy for portal vein tumor thrombosis2009

    • Author(s)
      Katamura Y, Aikata H, Takaki S, Azakami T, Kawaoka T, Waki K, Hiramatsu A, Kawakami Y, Takahashi S, Kenjo M, Toyota N, Ito K, Chayama K.
    • Journal Title

      J Gastroenterol 44(5)

      Pages: 492-502

    • NAID

      10025175131

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Randomized trial of high-dose interferon-alpha-2b combined with ribavirin in patients with chronic hepatitis C : Correlation between amino acid substitutions in the core/NS5A region and virological response to interferon therapy2009

    • Author(s)
      Mori N, Imamura M, Kawakami Y, Saneto H, Kawaoka T, Takaki S, Aikata H, Takahashi S, Chayama K, Hiroshima Liver Study Group
    • Journal Title

      J Med Virol 81(4)

      Pages: 640-649

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Antiviral activity, dose-response relationship, and safety of entecavir following 24-week oral dosing in nucleoside-naive Japanese adult patients with chronic hepatitis B : a randomized, double-blind, phase II clinical trial2009

    • Author(s)
      Shindo M, Chayama K, Mochida S, Toyota J, Tomita E, Kumada H, Yokosuka O, Sata M, Hayashi N, Suzuki K, Okanoue T, Tsubouchi H, Ishikawa H, Seriu T, Omata M.
    • Journal Title

      Hepatol Int 3

      Pages: 445-452

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice2009

    • Author(s)
      Hiraga N, Imamura M, Hatakeyama T, Kitamura S, Mitsui F, Tanaka S, TsugeM, Takahashi S, Abe H, Maekawa T, OchiH, Tateno C, Yoshizato K, Wakita T, Chayama K
    • Journal Title

      J Hepatol

      Volume: 51 Issue: 6 Pages: 1045-1054

    • DOI

      10.1016/j.jhep.2009.09.002

    • NAID

      120002036688

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice2009

    • Author(s)
      Ohira M, Ishiyama K, Tanaka Y, Doskali M, Igarashi Y, Tashiro H, Hiraga N, Imamura M, Sakamoto N, Asahara T, Chayama K.
    • Journal Title

      J Clin Invest 119(11)

      Pages: 3226-3235

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice2009

    • Author(s)
      Hiraga N, Imamura M, Hatakeyama T, Kitamura S, Mitsui F, Tanaka S, Tsuge M, Takahashi S, Abe H, Maekawa T, Ochi H, Tateno C, Yoshizato K, Wakita T, Chayama K.
    • Journal Title

      J Hepatol 51(6)

      Pages: 1046-1054

    • NAID

      120002036688

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Regular surveillance by imaging for early detection and better prognosis of hepatocellular carcinoma in patients infected with hepatitis C virus2009

    • Author(s)
      Noda I, Kitamoto M, Nakahara H, Hayashi R, Okimoto T, Monzen Y, Yamada H, Imagawa M, Hiraga N, Tanaka J, Chayama K
    • Journal Title

      J Gastroenterol 45

      Pages: 105-112

    • NAID

      10027214070

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] The first, Japanese case of COACH syndrome2009

    • Author(s)
      Mitsui F, Aikata H, Azakami T, Katamura Y, Kimura T, Kawaoka T, Saneto H, Takaki S, Hiraga N, Tsuge M, Waki K, Hiramatsu A, Imamura M, Kawakami Y, Takahashi S, Arihiro K, Chayama K.
    • Journal Title

      Hepatol Res. 39(3)

      Pages: 318-323

    • NAID

      10025325115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] A Polymorphism in MAPKAPK3 Affects Response to Interferon Therapy for Chronic Hepatitis C2009

    • Author(s)
      Tsukada H, Ochi H, Maekawa T, Abe H, Fujimoto Y, Tsuge M, Takahashi H, Kumada H, Kamatani N, Nakamura Y, Chayama K, the Hiroshima Liver Study Group, Toranomon Hospital
    • Journal Title

      Gastroenterology 136(5)

      Pages: 1796-1805

    • NAID

      120001700405

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Successful hepatitis B vaccination in liver transplant recipients with donor-specific hyporesponsiveness2009

    • Author(s)
      Tahara H, Tanaka Y, Ishiyama K, Ide K, Shishida M, Irei T, Ushitora Y, Ohira M, Banshodani M, Tashiro H, Itamoto T, Asahara T, Imamura M, Takahashi S, Chayama K, Ohdan H.
    • Journal Title

      Transpl Int. 22(8)

      Pages: 805-813

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Deletion of angiotensin II type I receptor reduces hepatic steatosis2009

    • Author(s)
      Nabeshima Y, Tazuma S, Kanno K, HyogoH, Chayama K
    • Journal Title

      J Hepatol

      Volume: 50 Issue: 6 Pages: 1226-1235

    • DOI

      10.1016/j.jhep.2009.01.018

    • NAID

      120001700483

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Chronic hepatitis C in patients co-infected with human immunodeficiency virus in Japan : a retrospective multicenter analysis2009

    • Author(s)
      Yotsuyanagi H, Kikuchi Y, Tsukada K, Nishida K, Kato M, Sakai H, Takamatsu J, Hige S, Chayama K, Moriya K, Koike K.
    • Journal Title

      Hepatol Res 39(7)

      Pages: 657-663

    • NAID

      10025326580

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] G-to-A hypermutation in hepatitis B virus (HBV) and clinical course of patients with chronic HBV infection2009

    • Author(s)
      Noguchi C, Imamura M, Tsuge M, Hiraga N, Mori N, Miki D, Kimura T, Takahashi S, Fujimoto Y, Ochi H, Abe H, Maekawa T, Tateno C, Yoshizato K, Chayama K.
    • Journal Title

      J Infect Dis 199(11)

      Pages: 1599-1607

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Evaluation of portosystemic collaterals by MDCT-MPR imaging for management of hemorrhagic esophageal varices2009

    • Author(s)
      Kodama H, Aikata H, Takaki S, Azakami T, Katamura Y, Kawaoka T, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Toyota N, Ito K, Chayama K.
    • Journal Title

      Eur J Radiol (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C : a Japanese multi-center study2009

    • Author(s)
      Okanoue T, Itch Y, Hashimoto H, Yasui K, Minami M, Takehara T, Tanaka E, Onji M, Toyota J, Chayama K, Yoshioka K, Izumi N, Akuta N, Kumada H.
    • Journal Title

      J Gastroenterol 44(9)

      Pages: 952-963

    • NAID

      10025581408

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C2009

    • Author(s)
      Tsukada H, Ochi H, Maekawa T, Abe H, Fujimoto Y, Tsuge M, Takahashi H, Kumada H, Kamatani N, Nakamura Y, Chayama K
    • Journal Title

      Gastroenterology

      Volume: 136 Issue: 5 Pages: 1796-1805.e6

    • DOI

      10.1053/j.gastro.2009.01.061

    • NAID

      120001700405

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Amphipathic DNA Polymers Inhibit Hepatitis C Virus Infection by Blocking Viral Entry2009

    • Author(s)
      Matsumura T, Hu Z, Kato T, Dreux M, Zhang YY, Imamura M, Hiraga N, Juteau JM, Cosset FL, Chayama K, Vaillant A, Liang TJ.
    • Journal Title

      Gastroenterolog 137(2)

      Pages: 673-681

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] FDG positron emission tomography/computed tomography for the detection of extrahepatic metastases from hepatocellular carcinoma2009

    • Author(s)
      Kawaoka T, Aikata H, Takaki S, Uka K, Azakami T, Saneto H, Jeong SC, Kawakami Y, Takahashi S, Toyota N, Ito K, Hirokawa Y, Chayama K.
    • Journal Title

      Hepatol Res 39(2)

      Pages: 134-142

    • NAID

      10025324381

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Evaluation of patients with esophageal varices after endoscopic injection sclerotherapy using multiplanar reconstruction MDCT images2009

    • Author(s)
      Kodama H, Aikata H, Takaki S, Takahashi S, Toyota N, Ito K, Chayama K.
    • Journal Title

      AJR Am J Roentgenol 192(1)

      Pages: 122-130

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry2009

    • Author(s)
      Kamatani Y, Wattanapokayakit S, OchiH, Kawaguchi T, Takahashi A, Hosono N, Kubo M, Tsunoda T, Kamatani N, KumadaH, Puseenam A, Sura T, Daigo Y, ChayamaK, Chantratita W, Nakamura Y, MatsudaK
    • Journal Title

      Nat Genet

      Volume: 41 Issue: 5 Pages: 591-595

    • DOI

      10.1038/ng.348

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice2009

    • Author(s)
      Ohira M, Ishiyama K, Tanaka Y, DoskaliM, Igarashi Y, Tashiro H, Hiraga N, Imamura M, Sakamoto N, Asahara T, Chayama K, Ohdan H
    • Journal Title

      J Clin Invest

      Volume: 119 Pages: 3226-3235

    • DOI

      10.1172/jci38374

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Transarterial infusion chemotherapy using cisplatin-lipiodol suspensior with or without embolization for unresectable hepatocellular carcinoma2009

    • Author(s)
      Kawaoka T, Aikata H, Takaki S, Katamura Y, Hiramatsu A, Waki K, Takahashi S, Hieda M, Toyota N, Ito K, Chayama K.
    • Journal Title

      Cardiovasc Intervent Radiol 32(4)

      Pages: 687-694

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Successful treatment of pulmonary metastases associated with advanced hepatocellular carcinoma by systemic 5-fluorouracil combined with interferon-alpha in a hemodialysis patient2009

    • Author(s)
      Katamura Y, Aikata H, Kimura Y, Azakami T, Kawaoka T, Takaki S, Waki K, Hiramatsu A, Kawakami Y, Takahashi S, Chayama K.
    • Journal Title

      Hepatol Res 39(4)

      Pages: 415-420

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Significant correlation between spleen volume and thrombocytopenia in liver transplant patients : a concept for predicting persistent thrombocytopenia2009

    • Author(s)
      Ohira M, Ishifuro M, Ide K, Irei T, Tashiro H, Itamoto T, Ito K, Chayama K, Asahara T, Ohdan H.
    • Journal Title

      Liver Transpl 15(2)

      Pages: 208-215

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry2009

    • Author(s)
      Matsumura T, Hu Z, Kato T, Dreux M, Zhang YY, Imamura M, Hiraga N, JuteauJM, Cosset FL, Chayama K, Vaillant A, Liang TJ
    • Journal Title

      Gastroenterology

      Volume: 137 Issue: 2 Pages: 673-681

    • DOI

      10.1053/j.gastro.2009.04.048

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Journal Article] Effects of a 24-week course of interferon-alpha therapy after curative treatment of hepatitis C virus-associated hepatocellular carcinoma.2007

    • Author(s)
      Jeong SC, Aikata H, Chayama K., et. al.
    • Journal Title

      World J Gastroenterol. 28;13(40)

      Pages: 5343-50

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659186
  • [Journal Article] Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C virus and its susceptibility to interferon2007

    • Author(s)
      Hiraga, N., Imamura, M., Tsuge, M., Chayama, K., et. al.
    • Journal Title

      FEBS Lett 15 : 581(10)

      Pages: 1983-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Pretreatment predictor of response, time to progression, and survival to intraarterial 5-fluorouracil/interferon combination therapy in patients with advanced hepatocellular carcinoma.2007

    • Author(s)
      Uka K, Aikata H, Takaki S, Miki D, Kawaoka T, Jeong SC, Chayama K., et. al.
    • Journal Title

      J Gastroenterol 42(10)

      Pages: 845-53

    • NAID

      10019970751

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659186
  • [Journal Article] Eicosapentaenoic acid could permit maintenance of the original ribavirin dose in chronic hepatitis C virus patients during the first 12 weeks of combination therapy with pegylated interferon-alpha and ribavirin. A prospective randomized controlled trial2007

    • Author(s)
      Takaki S, Kawakami Y, Imamura M, Aikata H, Takahashi S, Ishihara H, Tsuji, Chayama K., et. al.
    • Journal Title

      Intervirology 50(6)

      Pages: 439-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659186
  • [Journal Article] Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma2007

    • Author(s)
      Uka K, Chayama K. etal
    • Journal Title

      World J Gastroenterol 21;13(3)

      Pages: 414-20

    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Similar effects of recombinant interferon-alpha-2b and natural interferon-alpha when combined with intra-arterial 5-fluorouracil for the treatment of advanced hepatocellular carcinoma2007

    • Author(s)
      Uka K, Aikata H, Takaki S, Chayama K., et. al.
    • Journal Title

      Liver Int. 27(9)

      Pages: 1209-16

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma.2007

    • Author(s)
      Uka K, Aikata H, Chayama K, et. al.
    • Journal Title

      World J Gastroenterol. 21;13(3)

      Pages: 414-20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Similar effects of recombinant interferon-alpha-2b and natural interferon-alpha when combined with intra-arterial 5-fluorouracil for the treatment of advanced hepatocellular carcinoma2007

    • Author(s)
      Uka, K., Aikata, H., Takaki, S., Chayama, K., et. al.
    • Journal Title

      Liver Int 27(9)

      Pages: 1209-16

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Balloon-occluded retrograde transvenous obliteration for portal-systemic encephalopathy due to superior mesenteric-caval shunt via the right gonadal vein2007

    • Author(s)
      Katamura Y, Aikata H, Azakami T, Chayama K., et. al.
    • Journal Title

      Intern Med 46(17):

      Pages: 1479-80

    • NAID

      130000076076

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659186
  • [Journal Article] Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma2007

    • Author(s)
      Uka, K., Aikata, H., Chayama, K., et. al.
    • Journal Title

      World J Gastroenterol 21, 13(3)

      Pages: 414-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Susceptibility of chimeric mice with livers repopulated by serially subcultured human hepatocytes to hepatitis B virus2007

    • Author(s)
      Utoh, R., Tateno, C., Chayama, K., Yoshizato, K., et. al.
    • Journal Title

      Hepatology 47(2)

      Pages: 435-46

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Dual effect of APOBEC3G on Hepatitis B virus.2007

    • Author(s)
      Noguchi C, Chayama K., et. al.
    • Journal Title

      J Gen Virol 88(Pt 2)

      Pages: 432-40

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659186
  • [Journal Article] Similar effects of recombinant interferon-alpha-2b and natural interferon-alpha when combined with intra-arterial 5-fluorouracil for the treatment of advanced hepatocellular carcinoma2007

    • Author(s)
      Uka K, Aikata H, Takaki S, Chayama K., et. al.
    • Journal Title

      Liver Int. 27(9)

      Pages: 1209-16

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659186
  • [Journal Article] Balloon-occluded retrograde transvenous obliteration for portal-systemic encephalopathy due to superior mesenteric-caval shunt via the right gonadal vein2007

    • Author(s)
      Katamura, Y., Aikata, H., Azakami, T., Chayama, K., et. al.
    • Journal Title

      Intern Med 46(17)

      Pages: 1479-80

    • NAID

      130000076076

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Dual effect of APOBEC3G on Hepatitis B virus2007

    • Author(s)
      Noguchi C, Chayama K..etal
    • Journal Title

      J Gen Virol 88

      Pages: 432-40

    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Pretreatment predictor of response, time to progression, and survival to intraarterial 5-fluorouracil/interferon combination therapy in patients with advanced hepatocellular carcinoma.2007

    • Author(s)
      Uka K, Aikata H, Takaki S, Miki D, Kawaoka T, Jeong SC, Chayama K, et. al.
    • Journal Title

      J Gastroenterol 42(10)

      Pages: 845-53

    • NAID

      10019970751

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] The long-term outcome of patients with bleeding gastric varices after balloon-occluded retrograde transvenous obliteration.2007

    • Author(s)
      Hiraga N, Aikata H, Shirakawa H, Chayama K., et. al.
    • Journal Title

      J Gastroenterol 42(8)

      Pages: 663-72

    • NAID

      10019817220

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659186
  • [Journal Article] Effects of a 24-week course of interferon-alpha therapy after curative treatment of hepatitis C virus-associated hepatocellular carcinoma2007

    • Author(s)
      Jeong, S.C., Aikata, H., Chayama, K., et. al.
    • Journal Title

      World J Gastroenterol 28, 13(40)

      Pages: 5343-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Dual effect of APOBEC3G on Hepatitis B virus.2007

    • Author(s)
      Noguchi C, Chayama K, et. al.
    • Journal Title

      J Gen Virol 88(Pt2)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Successful treatment of an entecavir-resistant hepatitis B virus variant.2007

    • Author(s)
      Yatsuji H, Hiraga N, Kumada H, Chayama K, et. al.
    • Journal Title

      J Med Virol 79(12)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Effects of a 24-week course of interferon-alpha therapy after curative treatment of hepatitis C virus-associated hepatocellular carcinoma.2007

    • Author(s)
      Jeong SC, Aikata H, Chayama K, et. al.
    • Journal Title

      World J Gastroenterol. 28;13(40)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma.2007

    • Author(s)
      Uka K, Aikata H, Chayama K., et. al.
    • Journal Title

      World J Gastroenterol. 21;13(3)

      Pages: 414-20

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C virus and its susceptibility to interferon.2007

    • Author(s)
      Hiraga N, Imamura M, Tsuge M, Chayama K., et. al.
    • Journal Title

      FEBS Lett 15;581(10)

      Pages: 1983-7

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Pretreatment predictor of response, time to progression, and survival to intraarterial 5-fluorouracil/interferon combination therapy in patients with advanced hepatocellular carcinoma.2007

    • Author(s)
      Uka K, Aikata H, Takaki S, Miki D, Kawaoka T, Jeong SC, Chayama K., et. al.
    • Journal Title

      J Gastroenterol 42(10)

      Pages: 845-53

    • NAID

      10019970751

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C virus and its susceptibility to interferon.2007

    • Author(s)
      Hiraga N, Imamura M, Tsuge M, Chayama K, et. al.
    • Journal Title

      FEBS Lett 15;581(10)

      Pages: 1983-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Balloon-occluded retrograde transvenous obliteration for portal-systemic encephalopathy due to superior mesenteric-caval shunt via the right gonadai vein2007

    • Author(s)
      Katamura Y, Aikata H, Azakami T, Chayama K., et. al.
    • Journal Title

      Intern Med 46(17):

      Pages: 1479-80

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Balloon-occluded retrograde transvenous obliteration for portal-systemic encephalopathy due to superior mesenteric-caval shunt via the right gonadalvein2007

    • Author(s)
      Katamura Y, Aikata H, Azakami T, Chayama K, et. al.
    • Journal Title

      Intern Med 46(17):

      Pages: 1479-80

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C virus and its susceptibility to interferon.2007

    • Author(s)
      Hiraga N, Imamura M, Tsuge M, Chayama K., et. al.
    • Journal Title

      FEBS Lett 15;581(10)

      Pages: 1983-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659186
  • [Journal Article] Successful treatment of an entecavir-resistant hepatitis B virus variant.2007

    • Author(s)
      Yatsuji H, Hiraga N, Kumada H, Chayama K., et. al.
    • Journal Title

      J Med Virol 79(12)

      Pages: 1811-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659186
  • [Journal Article] Susceptibility of chimeric mice with livers repopulated by serially subcultured human hepatocytes to hepatitis B virus.2007

    • Author(s)
      Utoh R, Tateno C, Chayama K, Yoshizato K, et. al.
    • Journal Title

      Hepatology 47(2)

      Pages: 435-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Effects of a 24-week course of interferon-alpha therapy after curative treatment of hepatitis C virus-associated hepatocellular carcinoma.2007

    • Author(s)
      Jeong SC, Aikata H,, Chayama K., et. al.
    • Journal Title

      World J Gastroenterol. 28;13(40)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Eicosapentaenoic acid could permit maintenance of the original ribavirin dose in chronic hepatitis C virus patients during the first 12 weeks of combination therapy with pegylated interferon-alpha and ribavirin. A prospective randomized controlled trial2007

    • Author(s)
      Takaki, S., Kawakami, Y., Imamura, M., Aikata, H., Takahashi, S., Ishihara, H., Tsuji, Chayama, K., et. al.
    • Journal Title

      Intervirology 50(6)

      Pages: 439-46

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Efficacy of percutaneous cementoplasty for bone metastasis from hepatocellular carcinoma.2007

    • Author(s)
      Kodama H, Aikata H, Uka K, Chayama K., et. al.
    • Journal Title

      Oncology 72(5-6):

      Pages: 285-92

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Successful treatment of an entecavir-resistant hepatitis B virus variant2007

    • Author(s)
      Yatsuji, H., Hiraga, N., Kumada, H., Chayama, K., et. al.
    • Journal Title

      J Med Virol 79(12)

      Pages: 1811-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Pretreatment predictor of response, time to progression, and survival to intraarterial 5-fluorouracil/ interferon combination therapy in patients with advanced hepatocellular carcinoma2007

    • Author(s)
      Uka, K., Aikata, H., Takaki, S., Miki, D., Kawaoka, T., Jeong, S.C., Chayama, K., et. al.
    • Journal Title

      J Gastroenterol 42(10)

      Pages: 845-53

    • NAID

      10019970751

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Efficacy of percutaneous cementoplasty for bone metastasis from hepatocellular carcinoma2007

    • Author(s)
      Kodama, H., Aikata, H., Uka, K., Chayama, K., et. al.
    • Journal Title

      Oncology 72(5-6)

      Pages: 285-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Efficacy of percutaneous cementoplasty for bone metastasis from hepatocellular carcinoma.2007

    • Author(s)
      Kodama H, Aikata H, Uka K, Chayama K, et. al.
    • Journal Title

      Oncology 72(5-6):

      Pages: 285-92

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Dual effect of APOBEC3G on Hepatitis B virus2007

    • Author(s)
      Noguchi, C., Chayama, K., et. al.
    • Journal Title

      J Gen Virol 88(pt2)

      Pages: 432-40

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Dual effect of APOBEC3G on Hepatitis B virus.2007

    • Author(s)
      Noguchi C, Chayama K., et. al.
    • Journal Title

      J Gen Virol 88(Pt 2)

      Pages: 432-40

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] The long-term outcome of patients with bleeding gastric varices after balloon-occluded retrograde transvenous obliteration.2007

    • Author(s)
      Hiraga N, Aikata H, Shirakawa H, Chayama K, et. al.
    • Journal Title

      J Gastroenterol 42(8)

      Pages: 663-72

    • NAID

      10019817220

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] The long-term outcome of patients with bleeding gastric varices after balloon-occluded etrograde transvenous obliteration2007

    • Author(s)
      Hiraga, N., Aikata, H., Shirakawa, H., Chayama, K., et. al.
    • Journal Title

      J Gastroenterol 42(8)

      Pages: 663-72

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Eicosapentaenoic acid could permit maintenance of the original ribavirin dose in chronic hepatitis C virus patients during the first 12 weeks of combination therapy with pegylated interferon-alpha and ribavirin. A prospective randomized controlled trial2007

    • Author(s)
      Takaki S, Kawakami Y, Imamura M, Aikata H, Takahashi S, Ishihara H, Tsuji, Chayama K., et. al.
    • Journal Title

      Intervirology 50(6)

      Pages: 439-46

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Susceptibility of chimeric mice with livers repopulated by serially subcultured human hepatocytes to hepatitis B virus.2007

    • Author(s)
      Utoh R, Tateno C, Chayama K, Yoshizato K., et. al.
    • Journal Title

      Hepatology 47(2)

      Pages: 435-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659186
  • [Journal Article] Eicosapentaenoic acid could permit maintenance of the original ribavirin dose in chronic hepatitis C virus patients during the first 12 weeks of combination therapy with pegylated interferon-alpha and ribavirin. A prospective randomized controlled trial2007

    • Author(s)
      Takaki S, Kawakami Y, Imamura M, Aikata H, Takahashi S, Ishihara H, Tsuji, Chayama K, et. al.
    • Journal Title

      Intervirology 50(6)

      Pages: 439-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] The long-term outcome of patients with bleeding gastric varices after balloon-occluded retrograde transvenous obliteration.2007

    • Author(s)
      Hiraga N, Aikata H, Shirakawa H, Chayama K., et. al.
    • Journal Title

      J Gastroenterol 42(8)

      Pages: 663-72

    • NAID

      10019817220

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Successful treatment of an entecavir-resistant hepatitis B virus variant.2007

    • Author(s)
      Yatsuji H, Hiraga N,, Kumada H, Chayama K., et. al.
    • Journal Title

      J Med Virol 79(12)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Similar effects of recombinant interferon-alpha-2b and natural interferon-alpha when combined with intra-arterial 5-fluorouracil for the treatment of advanced hepatocellular carcinoma2007

    • Author(s)
      Uka K, Aikata H, Takaki S, Chayama K, et. al.
    • Journal Title

      Liver Int. 27(9)

      Pages: 1209-16

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma.2007

    • Author(s)
      Uka K, Aikata H, Chayama K., et. al.
    • Journal Title

      World J Gastroenterol. 21;13(3)

      Pages: 414-20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659186
  • [Journal Article] Efficacy of percutaneous cementoplasty for bone metastasis from hepatocellular carcinoma.2007

    • Author(s)
      Kodama H, Aikata H, Uka K, Chayama K., et. al.
    • Journal Title

      Oncology 72(5-6):

      Pages: 285-92

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659186
  • [Journal Article] Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis.2006

    • Author(s)
      Nabeshi, Chayama K. etal
    • Journal Title

      Biochem Biophys Res Commun 4;346(3)

      Pages: 658-64

    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Evolution of hepatitis C virus quasispecies during ribavirin and interferon-alpha-2b combination therapy and interferon-alpha-2b monotherapy.2006

    • Author(s)
      Arataki K, Chayama K. etal
    • Journal Title

      Intervirology. 49(6)

      Pages: 352-61

    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Emergence of a el lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif.2006

    • Author(s)
      Yatsuji H, Chayama K. etal
    • Journal Title

      Antimicrob Agents Chemother 50(11)

      Pages: 3867-74

    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Feasibility of freeze-dried sera for serological and molecular biological detection of hepatitis B and C viruses.2006

    • Author(s)
      Ohishi W, Chayama K. etal
    • Journal Title

      J Clin Microbiol 44(12)

      Pages: 4593-5

    • Data Source
      KAKENHI-PROJECT-18390218
  • [Journal Article] Prolonged negative HCV-RNA status led to a good outcome in chronic hepatitis C patients with genotype 1b and super-high viral load.2006

    • Author(s)
      Kohno H, Chayama K. etal
    • Journal Title

      Intervirology 49(6)

      Pages: 362-9

    • Data Source
      KAKENHI-PROJECT-18390218
  • [Patent] B型肝炎治療用核酸分子2019

    • Inventor(s)
      茶山一彰/吉間忠彦/水谷隆之
    • Industrial Property Rights Holder
      茶山一彰/吉間忠彦/水谷隆之
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-514692
    • Filing Date
      2019
    • Acquisition Date
      2019
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Patent] 急性重症肝炎モデル非ヒト動物の作製方法、急性重症肝炎モデル非ヒト動物、劇症肝炎治療薬のスクリーニング方法および劇症肝炎治療薬2014

    • Inventor(s)
      茶山一彰
    • Industrial Property Rights Holder
      茶山一彰
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-217516
    • Filing Date
      2014-10-24
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Presentation] ウイルス性肝炎研究の進歩と今後の課題2019

    • Author(s)
      茶山一彰
    • Organizer
      第23回日本肝臓学会大会
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Presentation] HCV治療の今後の展望-ウイルス性肝炎撲滅を目指した最新治療2019

    • Author(s)
      茶山一彰
    • Organizer
      第45回日本急性肝不全研究会
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Presentation] 肝硬変診療の課題2019

    • Author(s)
      茶山一彰
    • Organizer
      日本消化器関連学会機構(JDDW)2019
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Presentation] HCV治療の今後の展望-ウイルス性肝炎撲滅を目指した最新治療2019

    • Author(s)
      茶山一彰
    • Organizer
      第20回日本肝がん分子標的治療研究会
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Presentation] 最新のC型肝炎、肝硬変の治療2019

    • Author(s)
      茶山一彰
    • Organizer
      第33回日本臨床内科医学会
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Presentation] Malignant potential of early-stage serrated adenocarcinoma based on genetic analysis2018

    • Author(s)
      Urabe Y, Tanaka S, Hirano D, Nakamura K, Ninomiya Y, Yuge R, Hayashi R, Oka S, Kitadai Y, Shimamoto F, Arihiro K, Chayama K
    • Organizer
      26th United European Gastroenterology Week (UEGW) 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06269
  • [Presentation] Targeting Host and Viral Interactions: Insights from Mice Model2017

    • Author(s)
      Kazuaki Chayama
    • Organizer
      Asian Pacific Association for the Study of the Liver 2017(APASL 2017) (アジア太平洋肝臓病学会議)
    • Place of Presentation
      上海(中国)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15293
  • [Presentation] A mouse model of human CTL mediated severe acute hepatitis B2016

    • Author(s)
      茶山 一彰
    • Organizer
      第52回日本肝臓学会総会 特別企画1-JSH主催EASL Joint Meeting
    • Place of Presentation
      幕張
    • Data Source
      KAKENHI-PROJECT-15K15293
  • [Presentation] B型慢性肝炎治療の軌跡2016

    • Author(s)
      茶山 一彰
    • Organizer
      第20回日本肝臓学会大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-15K15293
  • [Presentation] Integrated safety and Tolerability of DCV+ASV in Patients with Chronic HCV Genotype 1b Infection2016

    • Author(s)
      Kazuaki Chayama
    • Organizer
      2016 APASL Single Topic Conference on Hepatitis C
    • Place of Presentation
      高雄(台湾)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15293
  • [Presentation] Recent Progress in Treatment for Chronic Hepatitis C2016

    • Author(s)
      茶山 一彰
    • Organizer
      2016アジア太平洋消化器病週間(APDW2016)
    • Place of Presentation
      神戸
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15293
  • [Presentation] Best Strategy for Curing HCV Genotype 1 and 4: East vs. West2016

    • Author(s)
      Kazuaki Chayama
    • Organizer
      2016 APASL Single Topic Conference on Hepatitis C
    • Place of Presentation
      高雄(台湾)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15293
  • [Presentation] B型肝炎2016

    • Author(s)
      茶山 一彰
    • Organizer
      第52回日本肝臓学会総会前期教育講演会
    • Place of Presentation
      幕張
    • Data Source
      KAKENHI-PROJECT-15K15293
  • [Presentation] Hepatitis B mouse model involving CTL2015

    • Author(s)
      茶山一彰
    • Organizer
      肝炎部会
    • Place of Presentation
      台北(台湾)
    • Year and Date
      2015-01-25
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Presentation] Optimizing triple therapy, and IFN/RBV free regimens2014

    • Author(s)
      茶山一彰
    • Organizer
      Asian Pacific Association for the Study of the Liver 2014(APASL 2014) (アジア太平洋肝臓病学会議)
    • Place of Presentation
      ブリスベン(オーストラリア)
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] New Treatment Paradigms for HCV: The Basics2014

    • Author(s)
      茶山一彰
    • Organizer
      Asian Pacific Association for the Study of the Liver 2014(APASL 2014) (アジア太平洋肝臓病学会議)
    • Place of Presentation
      ブリスベン(オーストラリア)
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] 肝炎ウイルスに対する創薬研究2014

    • Author(s)
      茶山一彰
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Presentation] 肝硬変の新たなマネージメント2014

    • Author(s)
      茶山一彰
    • Organizer
      第102回日本消化器病学会中国支部例会
    • Place of Presentation
      広島
    • Year and Date
      2014-11-29
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Presentation] 肝炎ウイルス感染と肝細胞癌2014

    • Author(s)
      茶山一彰
    • Organizer
      日本消化器関連学会機構(JDDW)2014
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-26
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Presentation] C型慢性肝炎に対する治療の最前線2014

    • Author(s)
      茶山一彰
    • Organizer
      日本内科学会北陸支部 第62回生涯教育講演会
    • Place of Presentation
      金沢
    • Year and Date
      2014-06-22
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Presentation] New Treatment Paradigms for HCV : The Basics、Asian Pacific Association for the Study of the Liver 2014(APASL 2014)2014

    • Author(s)
      茶山一彰
    • Organizer
      アジア太平洋肝臓病学会議
    • Place of Presentation
      ブリスベン(オーストラリア)
    • Year and Date
      2014-03-12
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] 肝癌に対する経カテーテル治療におけるDEB-TACEの位置づけ2014

    • Author(s)
      茶山一彰
    • Organizer
      第21回日本門脈圧亢進症学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-13
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Presentation] All-oral Dual Combination of Daclatasvir plus Asunaprevir Compared with Telaprevir plus Peginterferon Alfa/Ribavirin in Treatment-maive Japanese Patients ChronicallyInfected with HCV Genotype 1b:Results from a Phase 3 Study2014

    • Author(s)
      茶山一彰
    • Organizer
      The 65nd Annual Meeting of American Association for the Study of Liver Diseases 2014(AASLD)
    • Place of Presentation
      ボストン(アメリカ)
    • Year and Date
      2014-11-11
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Presentation] C型肝炎に対する最新の治療2014

    • Author(s)
      茶山一彰
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Presentation] Optimizing triple therapy, and IFN/RBV free regimens、Asian Pacific Association for the Study of the Liver 2014(APASL 2014)2014

    • Author(s)
      茶山一彰
    • Organizer
      アジア太平洋肝臓病学会議
    • Place of Presentation
      ブリスベン(オーストラリア)
    • Year and Date
      2014-03-12
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] C型肝炎撲滅に向けた治療戦略2014

    • Author(s)
      茶山一彰
    • Organizer
      第101回日本消化器病学会中国支部例会
    • Place of Presentation
      岡山
    • Year and Date
      2014-06-21
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Presentation] 講演1:DC Beadによる肝動脈化学塞栓療法 講演2:肝癌治療におけるイノベーション2014

    • Author(s)
      茶山一彰
    • Organizer
      第50回日本肝癌研究会
    • Place of Presentation
      京都
    • Year and Date
      2014-06-05
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Presentation] プロテアーゼ阻害剤の知見と問題点2014

    • Author(s)
      茶山一彰
    • Organizer
      第100回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-24
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Presentation] 肝動脈化学塞栓療法の新しい治療戦略2014

    • Author(s)
      茶山一彰
    • Organizer
      JDDW2014第18回日本肝臓学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-24
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Presentation] All-oral Combination of Daclatasvir Plus Asunaprevir in Interferon Ineligible Naive/Intolerant and Nonresponder Japanese Patients Chronically Infected with HCV Genotype 1b : Results from a Phase 3 Trial2013

    • Author(s)
      茶山一彰
    • Organizer
      The 64nd Annual Meeting of American Association for the Study of Liver Diseases 2013(AASLD)
    • Place of Presentation
      ワシントン D.C.(U.S.A.)
    • Year and Date
      2013-11-15
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] Direct antiviral agent 時代のC型肝炎治療の効果予測因子2013

    • Author(s)
      茶山一彰
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] ヒト肝細胞キメラマウスを使用した劇症肝炎モデル2013

    • Author(s)
      茶山一彰
    • Organizer
      第39回日本急性肝不全研究会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] C型慢性肝炎の最新治療2013

    • Author(s)
      茶山一彰
    • Organizer
      日本内科学会 平成25年度日本内科学会生涯教育講演会Aセッション
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] HCV in Asia IFN-free Regimen for Chronic Hepatitis C in Asia : A Phase IIIstudy in Japanese HCV Genotype 1b Patients2013

    • Author(s)
      茶山一彰
    • Organizer
      Conference Taiwan Association for the Study of the Liver(TASL)2013
    • Place of Presentation
      台湾
    • Year and Date
      2013-12-21
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] DAAs時代におけるC型慢性肝炎治療戦略と今後の展望2013

    • Author(s)
      茶山一彰
    • Organizer
      第17回日本肝臓学会大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] Studies on Hepatitis Viruses using human hepatocyte chimeric mice2013

    • Author(s)
      茶山一彰
    • Organizer
      第17回国際肝類洞壁研究シンポジウム(17th ISCHS)
    • Place of Presentation
      大阪
    • Year and Date
      2013-09-25
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] B型肝炎治療の最前線2013

    • Author(s)
      茶山一彰
    • Organizer
      第17回日本肝臓学会大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] C型肝炎に対するDAA製剤の治療効果2013

    • Author(s)
      茶山一彰
    • Organizer
      日本消化器病学会中国支部第17回教育講演会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] All-oral Combination of Daclatasvir Plus Asunaprevir in Interferon Ineligible Naïve/Intolerant and Nonresponder Japanese Patients Chronically Infected with HCV Genotype 1b:Results from a Phase 3 Trial2013

    • Author(s)
      茶山一彰
    • Organizer
      The 64nd Annual Meeting of American Association for the Study of Liver Diseases 2013(AASLD)
    • Place of Presentation
      ワシントンD.C.(U.S.A)
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] HCV Genotype,Variations Associated with IFN and DAA Resistance2013

    • Author(s)
      茶山一彰
    • Organizer
      Conference Taiwan Association for the Study of the Liver(TASL)2013
    • Place of Presentation
      台湾
    • Year and Date
      2013-12-21
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] C型慢性肝炎の最新治療2013

    • Author(s)
      茶山一彰
    • Organizer
      日本内科学会 平成25年度日本内科学会生涯教育講演会Aセッション
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] Treatment of Chronic Hepatitis C with First Generation Protease Inhibitors in Asian Population : Telaprevir-Based Triple Therapy in Japanese Population2013

    • Author(s)
      茶山一彰
    • Organizer
      TDDW2013(Taiwan Digestive Disease Week2013)
    • Place of Presentation
      台北(台湾)
    • Year and Date
      2013-10-05
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] C型肝炎の治療2013

    • Author(s)
      茶山一彰
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] Treatment of Chronic Hepatitis C with First Generation Protease Inhibitors in Asian Population:Telaprevir-Based Triple Therapy in Japanese Population2013

    • Author(s)
      茶山一彰
    • Organizer
      TDDW2013(Taiwan Digestive Disease Week2013)
    • Place of Presentation
      台北(台湾)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] HCV in Asia IFN-free Regimen for Chronic Hepatitis C in Asia: A Phase IIIstudy in Japanese HCV Genotype 1b Patients2013

    • Author(s)
      茶山一彰
    • Organizer
      Conference Taiwan Association for the Study of the Liver(TASL)2013
    • Place of Presentation
      台湾
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] C型慢性肝炎治療の最前線 3剤併用療法の最新のエビデンスと今後の展望2013

    • Author(s)
      茶山一彰
    • Organizer
      第17回日本肝臓学会大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] C型肝炎の最新の治療2013

    • Author(s)
      茶山一彰
    • Organizer
      第67回日本交通医学会総会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] ヒト肝細胞キメラマウスを用いたHCVの解析と治療2013

    • Author(s)
      茶山一彰
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] 次世代DAAによる新たなC型肝炎治療2013

    • Author(s)
      茶山一彰
    • Organizer
      第40回日本肝臓学会西部会
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-25670369
  • [Presentation] Biological analysis of hepatitis C virus using human hepatocyte chimeric mouse2012

    • Author(s)
      茶山一彰
    • Organizer
      アジア太平洋肝臓病学会議(APASL)
    • Place of Presentation
      台北、台湾(招待講演)
    • Year and Date
      2012-02-19
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] Biological analysis of hepatitis C virus using human hepatocyte chimeric mouse2012

    • Author(s)
      茶山一彰
    • Organizer
      アジア太平洋肝臓病学会議(APASL)
    • Place of Presentation
      台北、台湾(招待講演)
    • Year and Date
      2012-02-19
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] Dual Oral Combination Therapy with the NS5A Inhibitor BMS-790052 and the NS3 Protease Inhibitor BMS-650032 Achieved 90% Sustained Virologic Response(SVR12) in HCV Genotype 1b-Infected Null Responders2011

    • Author(s)
      Chayama Kazuaki
    • Organizer
      The 62nd Annual Meeting ofAmerican Association for the Study ofLiver Diseases(AASLD)
    • Place of Presentation
      SanFrancisco U. S. A
    • Year and Date
      2011-11-07
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] Dual Oral Combination Therapy with the NS5A Inhibitor BMS-790052 and the NS3 Protease Inhibitor BMS-650032 Achieved 90% Sustained Virologic Response(SVR12) in HCV Genotype 1b-Infected Null Responders2011

    • Author(s)
      Chayama Kazuaki
    • Organizer
      The 62nd Annual Meeting of American Association for the Study of Liver Diseases(AASLD)
    • Place of Presentation
      San Francisco U. S. A.
    • Year and Date
      2011-11-07
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] Dual Oral Combination Therapy with the NS5A Inhibitor BMS-790052 and the NS3 Protease Inhibitor BMS-650032 Achieved 90% Sustained Virologic Response (SVR12) in HCV Genotype 1b-Infected Null Responders2011

    • Author(s)
      茶山一彰
    • Organizer
      The 62nd Annual Meeting of American Association for the study of Liver Diseases(AASLD)
    • Place of Presentation
      アメリカサンフランシスコ(招待講演)
    • Year and Date
      2011-11-07
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] Dual Oral Combination Therapy with the NS5A Inhibitor BMS-790052 and the NS3 Protease Inhibitor BMS-650032 Achieved 90% Sustained Virologic Response (SVR12) in HCV Genotype 1b-Infected Null Responders2011

    • Author(s)
      茶山一彰
    • Organizer
      The 62nd Annual Meeting of American Association for the Study of Liver Diseases (AASLD)
    • Place of Presentation
      アメリカ サンフランシスコ(招待講演)
    • Year and Date
      2011-11-07
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] Biological analysis of hepatitis viruses using human hepatocyte chimeric mouse2011

    • Author(s)
      茶山一彰
    • Organizer
      第59回国際歯科研究学会日本部会総会・学術大会(JADR2011)
    • Place of Presentation
      広島(招待講演)
    • Year and Date
      2011-10-09
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] Biological analysis of hepatitis viruses using human hepatocyte chimeric mouse2011

    • Author(s)
      茶山一彰
    • Organizer
      第59回国際歯科研究学会日本部会総会・学術大会(JADR2011)
    • Place of Presentation
      広島(招待講演)
    • Year and Date
      2011-10-09
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] NAFLDの肝線維化と血小板数の関係について2010

    • Author(s)
      石飛朋和, 兵庫秀幸, 鍋島由宝, 石田友希, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] C型肝炎ウイルス感染におけるHLA DRB1とNKG2D遺伝子多型の影響2010

    • Author(s)
      大石和佳, 吉田健吾, 林奉権, 楠洋一郎, 藤原佐枝子, 柘植雅貴, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] Hepatitis C Virus Replication and Response to Anti-viral Drugs in Human Hepatocyte Chimeric Mice2010

    • Author(s)
      茶山一彰
    • Organizer
      第7回アジア太平洋肝臓病学会議(APASL)シングルトピックカンファレンス
    • Place of Presentation
      千葉市(招待講演)
    • Year and Date
      2010-12-17
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] ミラノ基準内Child A、B肝細胞癌症例に対する肝切除、ラジオ波治療後の予後から見た肝移植適応時期の検討2010

    • Author(s)
      片村嘉男, 高橋祥一, 茶山一彰
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-04-24
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] 骨転移合併肝細胞癌に対するゾレドロン酸の効果2010

    • Author(s)
      片村嘉男, 相方浩, 長沖祐子, 石田友希, 橋本義政, 河岡友和, 高木慎太郎, 脇浩司, 平松憲, 高橋祥一, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 肝細胞癌に対するCDDP/LPDを用いた経カテーテル的化学塞栓術反復療法とステージングシステムについての検討2010

    • Author(s)
      河岡友和, 相方浩, 長沖祐子, 橋本義政, 石田友希, 片村嘉男, 光井富貴子, 石飛朋和, 高木慎太郎, 平賀伸彦, 柘植雅貴, 平松憲, 脇浩司, 今村道雄, 川上由育, 兵庫秀幸, 高橋祥一, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] MRIによる肝線維化の評価2010

    • Author(s)
      橋本義政, 高木慎太郎, 石井康隆, 川瀬理恵, 小酒慶一, 寺崎元美, 永井健太, 中土井鋼一, 野田育江, 村上英介, 宮木大輔, 長沖祐子, 石田友希, 片村嘉男, 平松憲, 脇浩司, 相方浩, 高橋祥一, 茶山一彰, 福田浩
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-04-24
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] B型・C型肝炎合併CKD患者におけるステロイド薬、免疫抑制薬使用に関する考え方2010

    • Author(s)
      茶山一彰
    • Organizer
      第40回日本腎臓学会西部学術大会
    • Place of Presentation
      広島市(招待講演)
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] in vitro,in vivoモデルを用いた多剤耐性HBVに対する抗ウイルス効果の検討2010

    • Author(s)
      柘植雅貴, 平賀伸彦, 茶山一彰
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-04-22
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)における肝線維化と糖代謝異常の関連性について2010

    • Author(s)
      石田友希, 兵庫秀幸, 石飛朋和, 鍋島由宝, 長沖祐子, 橋本義政, 片村嘉男, 河岡友和, 高木慎太郎, 脇浩司, 平松憲, 川上由育, 相方浩, 高橋祥一, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] HCV感染マウスを用いたプロテアーゼ阻害剤およびRNAポリメラーゼ阻害剤の抗ウイルス効果の検討2010

    • Author(s)
      平賀伸彦, 今村道雄, 岩尾英治, 柘植雅貴, 光井富貴子, 河岡友和, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] HBV RT領域の変異と核酸アナログ耐性への影響2010

    • Author(s)
      柘植雅貴, 今村道雄, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] MRIによる肝線維化の評価2010

    • Author(s)
      橋本義政, 高木慎太郎, 石井康隆, 川瀬理恵, 小酒慶一, 寺崎元美, 永井健太, 中土井鋼一, 野田育江, 村上英介, 宮木大輔, 長沖祐子, 石田友希, 片村嘉男, 平松憲, 脇浩司, 相方浩, 高橋祥一, 茶山一彰, 福田浩
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-04-24
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] Personalized Medicine in Chronic Hepatitis B2010

    • Author(s)
      Chayama K
    • Organizer
      TASL 2020 Single Topic Conference
    • Place of Presentation
      台北(招待講演)
    • Year and Date
      2010-08-22
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] HBV感染ヒト肝細胞キメラマウスの血清中及び肝臓中cccDNA量の解析2010

    • Author(s)
      石田雄二, 眞田春美, 加国雅和, 島田卓, 茶山一彰, 立野知世
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] C型慢性肝炎患者におけるILB28多型とウイルス側および宿主側因子との関連2010

    • Author(s)
      今村道雄, 越智秀典, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] Hepatitis C Virus Replication and Response to Anti-viral Drugs in Human Hepatocyte Chimeric Mice2010

    • Author(s)
      茶山一彰
    • Organizer
      第7回アジア太平洋肝臓病学会議(APASL)シングルトピックカンファレンス
    • Place of Presentation
      千葉市(招待講演)
    • Year and Date
      2010-12-17
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] HCV感染マウスを用いたプロテアーゼ阻害剤およびRNAポリメラーゼ阻害剤の抗ウイルス効果の検討2010

    • Author(s)
      平賀伸彦, 今村道雄, 岩尾英治, 柘植雅貴, 光井富貴子, 河岡友和, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] C型肝炎ウイルス感染におけるHLA DRB1とNKG2D遺伝子多型の影響2010

    • Author(s)
      大石和佳, 吉田健吾, 林奉権, 楠洋一郎, 藤原佐枝子, 柘植雅貴, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 3cm以下単発、Child A肝細胞癌に対する肝切除とラジオ波焼灼療法の比較2010

    • Author(s)
      脇浩司, 相方浩, 長沖祐子, 石田友希, 橋本義政, 片村嘉男, 河岡友和, 高木慎太郎, 平松憲, 今村道雄, 川上由育, 高橋祥一, 田代裕尊, 大段秀樹, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 当院における生体肝移植ドナーの術後経過および診療の現況2010

    • Author(s)
      高木慎太郎, 大段秀樹, 茶山一彰
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-04-23
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] B型慢性肝炎の治療2010

    • Author(s)
      茶山一彰
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-04-24
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] Genotype1b・高ウイルス量以外のC型慢性肝炎に対するResponse-guided therapy2010

    • Author(s)
      北本幹也, 井川敦, 松本陽子, 山田博康, 川上由育, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] IL28の多型とC型慢性肝炎の炎症、繊維化、γGTPとの関連2010

    • Author(s)
      阿部弘美, 越智秀典, 柘植雅貴, 三木大樹, 光井富貴子, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)における肝線維化と糖代謝異常の関連性について2010

    • Author(s)
      石田友希, 兵庫秀幸, 石飛朋和, 鍋島由宝, 長沖祐子, 橋本義政, 片村嘉男, 河岡友和, 高木慎太郎, 脇浩司, 平松憲, 川上由育, 相方浩, 高橋祥一, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] HBV RT領域の変異と核酸アナログ耐性への影響2010

    • Author(s)
      柘植雅貴, 今村道雄, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] C型慢性肝炎患者に対するPegIFN/RBV療法の治療効果とIL28 locusのSNPおよび肝内IFN誘導遺伝子発現量の関連2010

    • Author(s)
      阿部弘美, 越智秀典, 柘植雅貴, 三木大樹, 光井富貴子, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] Angio-CTでは指摘されずGd-EOB DTPA造影MRI肝細胞相でのみ指摘される結節についての検討2010

    • Author(s)
      高木慎太郎, 橋本義政, 長沖祐子, 石田友希, 片村嘉男, 河岡友和, 柘植雅貴, 平松憲, 脇浩司, 今村道雄, 川上由育, 兵庫秀幸, 相方浩, 高橋祥一, 柿沢秀明, 福田浩, 堀口純, 永田靖, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] Genotype1b・高ウイルス量以外のC型慢性肝炎に対するResponse-guided therapy2010

    • Author(s)
      北本幹也, 井川敦, 松本陽子, 山田博康, 川上由育, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] B型慢性肝炎の治療2010

    • Author(s)
      茶山一彰
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-04-24
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] ミラノ基準内Child A、B肝細胞癌症例に対する肝切除、ラジオ波治療後の予後から見た肝移植適応時期の検討2010

    • Author(s)
      片村嘉男, 高橋祥一, 茶山一彰
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-04-24
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] Personalized Medicine in Chronic Hepatitis B2010

    • Author(s)
      Chayama K
    • Organizer
      TASL 2020 Single Topic Conference
    • Place of Presentation
      台北(招待講演)
    • Year and Date
      2010-08-22
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] 骨転移合併肝細胞癌に対するゾレドロン酸の効果2010

    • Author(s)
      片村嘉男, 相方浩, 長沖祐子, 石田友希, 橋本義政, 河岡友和, 高木慎太郎, 脇浩司, 平松憲, 高橋祥一, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] IL28の多型とC型慢性肝炎の炎症、繊維化、γGTPとの関連2010

    • Author(s)
      阿部弘美, 越智秀典, 柘植雅貴, 三木大樹, 光井富貴子, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 当院における生体肝移植ドナーの術後経過および診療の現況2010

    • Author(s)
      高木慎太郎, 大段秀樹, 茶山一彰
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-04-23
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] 肝移植後C型肝炎再燃に対するIFN治療の現況とSVR率改善のための検討2010

    • Author(s)
      河岡友和, 高橋祥一, 田代裕尊, 大段秀樹, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] Angio-CTでは指摘されずGd-EOB DTPA造影MRI肝細胞相でのみ指摘される結節についての検討2010

    • Author(s)
      高木慎太郎, 橋本義政, 長沖祐子, 石田友希, 片村嘉男, 河岡友和, 柘植雅貴, 平松憲, 脇浩司, 今村道雄, 川上由育, 兵庫秀幸, 相方浩, 高橋祥一, 柿沢秀明, 福田浩, 堀口純, 永田靖, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] in vitro, in vivoモデルを用いた多剤耐性HBVに対する抗ウイルス効果の検討2010

    • Author(s)
      柘植雅貴, 平賀伸彦, 茶山一彰
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-04-22
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] B型・C型肝炎合併CKD患者におけるステロイド薬、免疫抑制薬使用に関する考え方2010

    • Author(s)
      茶山一彰
    • Organizer
      第40回日本腎臓学会西部学術大会
    • Place of Presentation
      広島市(招待講演)
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] 肝移植後C型肝炎再燃に対するIFN治療の現況とSVR率改善のための検討2010

    • Author(s)
      河岡友和, 高橋祥一, 田代裕尊, 大段秀樹, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 肝外転移合併肝細胞癌に対するS1 based全身化学療法の検討2010

    • Author(s)
      相方浩, 片村嘉男, 橋本義政, 長沖祐子, 河岡友和, 高木慎太郎, 平松憲, 脇浩司, 川上由育, 高橋祥一, 茶山一彰
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-04-22
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] C型慢性肝炎に対するインターフェロン治療におけるILB28多型とCore領域変異の影響2010

    • Author(s)
      今村道雄, 越智秀典, 茶山一彰
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-04-23
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] 3cm以下単発、Child A肝細胞癌に対する肝切除とラジオ波焼灼療法の比較2010

    • Author(s)
      脇浩司, 相方浩, 長沖祐子, 石田友希, 橋本義政, 片村嘉男, 河岡友和, 高木慎太郎, 平松憲, 今村道雄, 川上由育, 高橋祥一, 田代裕尊, 大段秀樹, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] HCV関連ミラノ基準内肝細胞癌に対する根治治療後の予後 IFN効果とミラノ基準逸脱時期の検討を含めて2010

    • Author(s)
      相方浩, 片村嘉男, 橋本義政, 長沖祐子, 河岡友和, 高木慎太郎, 平松憲, 脇浩司, 川上由育, 高橋祥一, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] 肝細胞癌に対するCDDP/LPDを用いた経カテーテル的化学塞栓術反復療法とステージングシステムについての検討2010

    • Author(s)
      河岡友和, 相方浩, 長沖祐子, 橋本義政, 石田友希, 片村嘉男, 光井富貴子, 石飛朋和, 高木慎太郎, 平賀伸彦, 柘植雅貴, 平松憲, 脇浩司, 今村道雄, 川上由育, 兵庫秀幸, 高橋祥一, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] HCV関連ミラノ基準内肝細胞癌に対する根治治療後の予後 IFN効果とミラノ基準逸脱時期の検討を含めて2010

    • Author(s)
      相方浩, 片村嘉男, 橋本義政, 長沖祐子, 河岡友和, 高木慎太郎, 平松憲, 脇浩司, 川上由育, 高橋祥一, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] C型慢性肝炎患者に対するPegIFN/RBV療法の治療効果とIL28 locusのSNPおよび肝内IFN誘導遺伝子発現量の関連2010

    • Author(s)
      阿部弘美, 越智秀典, 柘植雅貴, 三木大樹, 光井富貴子, 平賀伸彦, 今村道雄, 高橋祥一, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] C型慢性肝炎患者におけるILB28多型とウイルス側および宿主側因子との関連2010

    • Author(s)
      今村道雄, 越智秀典, 茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 慢性肝疾患に対する脾臓摘出術の効果と合併症2010

    • Author(s)
      田代裕尊, 艮雄一郎, 天野尋暢, 大下彰彦, 小林剛, 谷本新学, 黒田慎太郎, 田澤宏文, 相方浩, 高橋祥一, 茶山一彰, 浅原利正, 板本敏行, 大段秀樹
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] NAFLDの肝線維化と血小板数の関係について2010

    • Author(s)
      石飛朋和, 兵庫秀幸, 鍋島由宝, 石田友希,茶山一彰
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] HBV感染ヒト肝細胞キメラマウスの血清中及び肝臓中cccDNA量の解析2010

    • Author(s)
      石田雄二, 眞田春美, 加国雅和, 島田卓, 茶山一彰, 立野知世
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-22659147
  • [Presentation] C型慢性肝炎に対するインターフェロン治療におけるILB28多型とCore領域変異の影響2010

    • Author(s)
      今村道雄, 越智秀典, 茶山一彰
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-04-23
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 慢性肝疾患に対する脾臓摘出術の効果と合併症2010

    • Author(s)
      田代裕尊, 艮雄一郎, 天野尋暢, 大下彰彦, 小林剛, 谷本新学, 黒田慎太郎, 田澤宏文, 相方浩, 高橋祥一, 茶山一彰, 浅原利正, 板本敏行, 大段秀樹
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 肝外転移合併肝細胞癌に対するS1 based全身化学療法の検討2010

    • Author(s)
      相方浩, 片村嘉男, 橋本義政, 長沖祐子, 河岡友和, 高木慎太郎, 平松憲, 脇浩司, 川上由育, 高橋祥一, 茶山一彰
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2010-04-22
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 当院で治療した急性肝不全患者50例の成因と予後2009

    • Author(s)
      平松憲, 高橋祥一, 石田友希, 片村嘉男, 河岡友和, 高木慎太郎, 柘植雅貴, 脇浩司, 今村道雄, 川上由育, 兵庫秀幸, 相方浩, 田代裕尊, 板本敏行, 大段秀樹, 茶山一彰
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] C型慢性肝炎治療の最前線~次世代の治療薬を見据えて~2009

    • Author(s)
      茶山一彰
    • Organizer
      JDDW 2009
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-10-14
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 肝細胞癌に対するシスプラチン/リピオドールを用いた経カテーテル的肝動脈化学塞栓術において, アナフィラキシー症状を起こした症例の検討2009

    • Author(s)
      河岡友和, 相方浩, 石田友希, 片村嘉男, 阿座上隆広, 高木慎太郎, 平松憲, 脇浩司, 今村道雄, 川上由育, 高橋祥一, 茶山一彰
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 生体肝移植後のウイルス肝炎に対する治療2009

    • Author(s)
      河岡友和, 高橋祥一, 茶山一彰
    • Organizer
      第95回日本消化器病学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-05-07
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 肝細胞癌長期生存例の検討2009

    • Author(s)
      平松憲, 相方浩, 茶山一彰
    • Organizer
      第91回日本消化器病学会中国支部例会
    • Place of Presentation
      岡山市
    • Year and Date
      2009-06-13
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] THE USEFULNESS OF SONAZOID CONTRAST-ENHANCEDULTRASONOGRAPHY FOR GROSS CLASSIFICATION OF HEPATOCELLULAR CARCINOMA2009

    • Author(s)
      Takaki S, Aikata H, Nagaoki Y, Kimura Y, Hashimoto Y, Katamura Y, Kawaoka T, Hiramatsu A, Waki K, Takahashi S, Chayama K.
    • Organizer
      3rd International Kobe Liver Symposium on HCC with a JSH-ILCA Joint Scientific Session
    • Place of Presentation
      神戸市
    • Year and Date
      2009-06-06
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] PERCUTANEOUS RADIOFREQUENCY ABLATION FOR RECURRENT HEPATOCELLULAR CARCINOMA AFTER CURATIVE TREATMENT : RESULTS AND PROGNOSTIC FACTORS ON LONG-TERM FOLLOW-UP2009

    • Author(s)
      Waki K, Aikata H, Nagaoki Y, Kimura Y, Hashimoto Y, Katamura Y, Kawaoka T, Takaki S, Hiramatsu A, Takahashi S, Chayama K.
    • Organizer
      3rd International Kobe Liver Symposium on HCC with a JSH-ILCA Joint Scientific Session
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-06
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] B型慢性肝疾患における Lamivudine, Adefovir 併用療法の治療効果と薬剤血中濃度との関連性の検討2009

    • Author(s)
      光井富貴子, 柘植雅貴, 河岡友和, 實藤宏美, 畠山剛, 北村正輔, 平賀伸彦, 今村道雄, 川上由育, 相方浩, 高橋祥一, 茶山一彰
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] PEG-I FNα-2b/Ribavirin 併用療法におけるHCVcore 抗体価比を指標とした治療期間の設定2009

    • Author(s)
      川上由育, 高橋祥一, 茶山一彰
    • Organizer
      第95回日本消化器病学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-05-07
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 肝外転移合併肝細胞癌に対するTS-1/CDDP併用療法2009

    • Author(s)
      片村嘉男, 相方浩, 石田友希, 阿座上隆広, 河岡友和, 高木慎太郎, 脇浩司, 平松憲, 川上由育, 高橋祥一, 茶山一彰
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] in vitro, in vivo モデルを用いた核酸アナログに対するHBVの抗ウイルス効果の検討2009

    • Author(s)
      柘植雅貴, 今村道雄, 茶山一彰
    • Organizer
      第95回日本消化器病学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-05-07
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] HBs抗体に対する escape mutant の出現とその解析2009

    • Author(s)
      柘植雅貴, 高橋祥一, 高木慎太郎, 石田友希, 片村嘉男, 阿座上隆広, 河岡友和, 實藤宏美, 光井富貴子, 平賀伸彦, 平松憲, 脇浩司, 今村道雄, 川上由育, 兵庫秀幸, 相方浩, 茶山一彰
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] HCV感染マウスを用いた Telaprevir の抗ウイルス効果の検討2009

    • Author(s)
      平賀伸彦, 今村道雄, 岩尾英治, 柘植雅貴, 光井富貴子, 河岡友和, 實藤宏美, 高橋祥一, 茶山一彰
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] C型肝炎ウイルスのクリアランスと感染持続における HLA-DRB1 対立遺伝子の影響2009

    • Author(s)
      大石和佳, 林奉権, 楠洋一郎, 藤原佐枝子, 茶山一彰
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] ヒト肝細胞キメラマウスを用いた治療抵抗性の肝炎に関する研究2009

    • Author(s)
      茶山一彰
    • Organizer
      第27回 犬山シンポジウム
    • Place of Presentation
      愛知
    • Year and Date
      2009-08-06
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] ANALYSIS OF CLINICAL FEATURES OF PATIENTS WITH HEPATOCELLULAR CARCINOMA SURVIVING MORE THAN 10 YEARS2009

    • Author(s)
      Hiramatsu A, Aikata H, Nagaoki Y, Kimura Y, Hashimoto Y, Katamura Y, Kawaoka T, Takaki S, Waki K, Takahashi S, Chayama K
    • Organizer
      3rd International Kobe Liver Symposium on HCC with a JSH-ILCA Joint Scientific Session
    • Place of Presentation
      神戸市
    • Year and Date
      2009-06-06
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] C型肝癌根治後のPegIFN α2a 少量長期投与の可能性2009

    • Author(s)
      橋本義政, 川上由育, 長沖祐子, 石田友希, 横山聡栄, 片村嘉男, 光井富貴子, 河岡友和, 實藤宏美, 石飛朋和, 鍋島由宝, 平賀伸彦, 相方浩, 高橋祥一, 茶山一彰
    • Organizer
      第91回日本消化器病学会中国支部例会
    • Place of Presentation
      岡山市
    • Year and Date
      2009-06-13
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] HCVCOre, ISDRのアミノ酸変異とPEG-IFN+リバビリン療法の治療成績およびHCV感染モデルマウスを用いたウイルス学的検討2009

    • Author(s)
      今村道雄, 平賀伸彦, 茶山一彰
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 肝細胞癌根治療法後の初回再発癌に対するRFA の治療成績2009

    • Author(s)
      脇浩司, 相方浩, 石田友希, 片村嘉男, 阿座上隆広, 河岡友和, 高木慎太郎, 平松憲, 今村道雄, 川上由育, 高橋祥一, 茶山一彰
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)の診断・経時的変化に終末糖化産物が有用である可能性について2009

    • Author(s)
      兵庫秀幸, 田妻進, 茶山一彰
    • Organizer
      第95回日本消化器病学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-05-07
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 治療方針のコンセンサス2009

    • Author(s)
      茶山一彰, 今村道雄, 高橋祥一
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 肝癌組織における fluorouracil 関連遺伝子の検討2009

    • Author(s)
      阿座上隆広, 川上由育, 石田友希, 片村嘉男, 河岡友和, 實藤宏美, 平松憲, 脇浩司, 相方浩, 高橋祥一, 有広光司, 大段秀樹, 茶山一彰
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] B型肝癌根治治療後の核酸アナログ投与による肝癌再発抑制効果の検討2009

    • Author(s)
      平松憲, 相方浩, 茶山一彰
    • Organizer
      第95回日本消化器病学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-05-07
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] INTRAARTERIAL 5-FLUOROURACIL/INTERFERON COMBINATION THERAPY FOR HEPATOCELLULAR CARCINOMA WITH PORTAL VEIN TUMOR THROMBOSIS AND EXTRAHEPATIC METASTASES2009

    • Author(s)
      Katamura Y, Aikata H, Kimura Y, Kawaoka T, Takaki S, Waki K, Hiramatsu A, Kawakami Y, Takahashi S, Chayama K.
    • Organizer
      3rd International Kobe Liver Symposium on HCC with a JSH-ILCA Joint Scientific Session
    • Place of Presentation
      神戸市
    • Year and Date
      2009-06-06
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] Professor of Research, BCLC Group.Liver Unit, IDIBAPS, Barcelona Josep M Llovet2009

    • Author(s)
      茶山一彰
    • Organizer
      MDHCC update Seminar
    • Place of Presentation
      Boston, USA
    • Year and Date
      2009-11-01
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 食道静脈瘤患者のマネージメントにおけるMDCTによる門脈系再構築画像の有用性2009

    • Author(s)
      相方浩, 児玉英章, 片村嘉男, 河岡友和, 阿座上隆広, 高木慎太郎, 平松憲, 脇浩司, 今村道雄, 川上由育, 高橋祥一, 茶山一彰
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 当科における食道静脈瘤破裂の治療成績と標準化に向けた治療方針2009

    • Author(s)
      児玉英章, 相方浩, 阿座上隆広, 片村嘉男, 河岡友和, 高木慎太郎, 平松憲, 脇浩司, 今村道雄, 川上由育, 高橋祥一, 茶山一彰
    • Organizer
      第77回 日本消化器内視鏡学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-05-21
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)の拾い上げに糖代謝異常が重要である可能性について2009

    • Author(s)
      石田友希, 兵庫秀幸, 鍋島肉宝, 石飛朋和, 長沖祐子, 橋本義政, 片村嘉男, 高木慎太郎, 脇浩司, 平松憲, 相方浩, 高橋祥一, 茶山一彰
    • Organizer
      第91回日本消化器病学会中国支部例会
    • Place of Presentation
      岡山市
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 非アルコール性脂肪性肝炎の臨床病態とAGE-RAGE axis の関連性2009

    • Author(s)
      石飛朋和, 兵庫秀幸, 山岸昌一, 竹内正義, 石田友希, 鍋島由宝, 茶山一彰
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] C型慢性肝委患者血清中の欠損型 HCV ゲノムの同定とその臨床的意義の解析2009

    • Author(s)
      畠山剛, 柘植雅貴, 阿部弘美, 北村正輔, 光井富貴子, 平賀伸彦, 今村道雄, 川上由育, 相方浩, 高橋祥一, 茶山一彰
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] APOBEC3B遺伝子の欠失多型がB型肝炎ウイルスの持続感染と病態に及ぼす影響2009

    • Author(s)
      阿部弘美, 越智秀典, 前川敏郎, 藤本佳史, 柘植雅貴, 今村道雄, 平賀伸彦, 高橋祥一, 茶山一彰
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 慢性肝疾患に対する生体肝移植後の効果的な抗ウイルス療法と術後胆管狭窄に対する対策2009

    • Author(s)
      高橋祥一, 河岡友和, 茶山一彰
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] 進行肝細胞癌に対するIFN併用5FU肝動注療法における、門脈腫瘍栓への3次元体放射線照射併用の意義2009

    • Author(s)
      相方浩, 片村嘉男, 茶山二彰
    • Organizer
      第95回日本消化器病学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-05-07
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] Evaluation of long-term entecavir (ETV) treatment in chronic hepatitis B (CHB) patients swiched from 24 weeks lamivudine (LVD) therapy2009

    • Author(s)
      Tsuge M, Chayama K, Shindo M, Toyota J, Mochida S, Tomita E, Kumada H, Yamada G, Yatsuhashi H, Sata M, Yokosuka O, Hayashi N, Ishikawa H, Seriu T, Omata M.
    • Organizer
      APASL
    • Place of Presentation
      香港
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21390229
  • [Presentation] Successful Therapy with the NS5A Inhibitor Daclatasvir and NS3 Protease Inhibitor Asunaprevir in HCV Genotype 1B-infected Null Responders or Ineligible /Intolerant to PE

    • Author(s)
      茶山一彰
    • Organizer
      第98回日本消化器病学会総会 第3回国際交流フォーラム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Presentation] C型肝炎治療の新展開と到達点

    • Author(s)
      茶山一彰
    • Organizer
      JDDW2014第18回日本肝臓学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23 – 2014-10-24
    • Data Source
      KAKENHI-PROJECT-26670383
  • [Presentation] ウイルス肝炎 最近の話題

    • Author(s)
      茶山一彰
    • Organizer
      第98回日本消化器病学会中国支部例会
    • Place of Presentation
      宇部
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Presentation] Successful Therapy with the NS5A Inhibitor and NS3 Protease Inhibitor to Chronic HCV Genotype 1B-Infected Patients

    • Author(s)
      茶山一彰
    • Organizer
      第10回日本肝臓学会シングルトピックカンファレンス
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Presentation] C型肝炎に関する研究手法の進歩と臨床応用

    • Author(s)
      茶山一彰
    • Organizer
      第77回日本インターフェロン・サイトカイン学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Presentation] Treatment of Chronic HCV Genotype 1B-Infected Patients with Peg-IFN/Ribavirin/Telaprevir Triple Therapy

    • Author(s)
      茶山一彰
    • Organizer
      第10回日本肝臓学会シングルトピックカンファレンス
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Presentation] C型慢性肝炎~最新の治療~

    • Author(s)
      茶山一彰
    • Organizer
      日本消化器病学会中国支部 第15回教育講演会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-24659368
  • [Presentation] C型肝炎治療の最新の話題

    • Author(s)
      茶山一彰
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-24659368
  • 1.  Yokosaki Yasuyuki (80210607)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  IKEDA Kenji (80211027)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  KUMADA Hiromitsu (20124307)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  高橋 祥一 (30372692)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  仙谷 和弘 (30508164)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  三木 大樹 (10584592)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 7.  茶山 弘美 (70572329)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  石原 浩人 (10325160)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  正木 崇生 (30397913)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  林 亮平 (80772053)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 11.  西道 教尚 (00583486)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  Hayes C.Nelson (50572327)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 13.  TSUJINO KAZUYUKI
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  ABE Hiromi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 48 results
  • 15.  YONEDA Masato
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 16.  NISHINA Sohji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  HARA Yuichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  MATSUDA Koichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  TANIKAWA Chizu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  OHISHI Waka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  KITAMOTO Aya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 22.  UENO Masaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  HOTTA Kikuko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  Ono Masafumi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 25.  Sumida Yoshio
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  Hyogo Hideyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 27.  ASAHINA Yasuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  NAKAGAWA Hidewaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  HATANAKA Yutaka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  西原 利治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 31.  持田 智
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  日野 啓輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 33.  大段 秀樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 34.  田中 友加
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 35.  柘植 雅貴
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 36.  ZHANG YIZHOU
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 37.  千葉 哲博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 38.  加藤 幸夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  中原 桂子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 40.  星野 真一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 41.  北本 卓也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 42.  蒔田 直昌
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 43.  藤田 征志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 44.  山上 裕機
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 45.  速水 晋也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 46.  日浅 陽一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 47.  榎本 信幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 48.  鎌田 佳宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 49.  楠 洋一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 50.  林 奉権
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 51.  中地 敬
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 52.  松井 啓隆
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 53.  金井 昭教
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 54.  佐久間 哲史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 55.  大上 直秀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 56.  安井 弥
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 57.  山本 直樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 58.  角田 達彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 59.  藤本 明洋
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 60.  宮 冬樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 61.  三橋 智子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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