Tokunaga Fuminori 徳永文稔

… Alternative Names

Researcher Number	00212069
Other IDs	https://orcid.org/0000-0003-3626-9119
Affiliation (Current)	2021: 大阪市立大学, 大学院医学研究科, 教授
Affiliation (based on the past Project Information) *help	2021: 大阪市立大学, 医学(系)研究科(研究院), 教授 2016 – 2020: 大阪市立大学, 大学院医学研究科, 教授 2017: 大阪市立大学, 医学(系)研究科(研究院), 教授 2011 – 2015: 群馬大学, 生体調節研究所, 教授 2010: Osaka University, 医学(系)研究科(研究院), 准教授 … More
Review Section/Research Field	Principal Investigator Biological Sciences / Structural biochemistry / General medical chemistry / Structural biochemistry / Pathological medical chemistry / Functional biochemistry / Basic Section 48040:Medical biochemistry-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields Except Principal Investigator Biological Sciences / Structural biochemistry … More
Keywords	Principal Investigator 酵素 / 細胞・組織 / タンパク質 / 蛋白質 / ユビキチン / 炎症 / シグナル伝達 / 細胞・組織 / プロテアソーム / 免疫学 … More Except Principal Investigator プロテインC / 品質管理機構 / プロテアソーム / 小胞体品質管理機構 / タンパク分解 / 細胞内分解 / 分子シャペロン / 小胞体 / アンチトロンビン / 20Sプロテアソーム / 小胞体プロテアソーム / マンノーストリミング / マンノシダーゼI / タンパク質分解 / シグナル伝達 / 数理モデル / プロテインC欠乏症 / Thrombosis / Protein C / Protein C deficiency / セリンプロテア-ゼ / Serine protease / cDNA cloning / 分泌異常 / 小胞体品質管理 / 小胞体関連分解 / ER-Associated Degradation / Edem / 炎症 / ワルファリン / グルコーストリミング / 糖鎖修飾 / キフネンシン / タンパク質 / 分解 / ユビキチン / 蛋白質 / ストレス / 癌 / 生体分子 / 翻訳後修飾 / 疾患 / 構造生物学 / 血栓症 / 多型性 / 遺伝子解析 / 第3染色体 / プロテインCインヒビタ- / 高ヒスチジン糖タンパク質 / プロテインC異常症 / HRG / PCR / PCR法 / Polymorphism / Gene analysis / Histidine-rich glycoprotein / Protein C inhibitor / Chromosome 3 / 体液凝固 / カブトガニ血球細胞 / B因子 / G因子 / βー1,3ーグルカン / 細菌内毒素 / cDNAクロ-ニング / 体液凝固因子 / 無脊椎動物 / 真菌類 / カブトガニ血球 / Proclotting enzyme / IX因子 / トロンビン / タキプレシン / ゲノム解析 / 抗菌性ペプチド / Horseshoe crab / Blood coagulation / Factor B / Factor G / beta-1, 3-glucan / Bacterial endotoxin / ワ-ファリン / ビタミンK / 293細胞 / BHK細胞 / 小細体内分解 / 小胞体内分解 / 異常プロテインC / 遺伝子発現 / 蛋白質の膜透過 / 蛋白質の細胞内移行 / Recombinant Mutants / Vitamin K / Warfarin / Endoplasmic reticulum-associated protein degradation / Quality control / ERbプロテアソーム / ラット肝 / ERbプロアテソーム / ミクロソーム / ERaプロテアソーム / Proteasome / ERb Proteasome / 20S Proteasome / Quality Control in the Endoplasmic reticulum / Rat Liver / チログロブリン / 新生タンパク質 / アンチトロンビン変異体 / 変異タンパク質 / Quality Control / Molecular Chaperones / Antithrombin / Mannosidase I / Mannose Trimming / Thyroglobulin / 血液凝固IX因子 / EGF様ドメイン / 血友病B / 分子異常症 / 血液凝固VII因子 / エステル基質 / IX因子Fukuoka / Factor VII / EGF-like domain / Oligosaccharide / Protein Z / Factor IX / gamma-Carboxyglutamic acid residue / LRBA / IFN経路 / 免疫 / 乳癌 / 数理シグナル / 直鎖状ユビキチン鎖 / 炎症性疾患 / NF-kB / 細胞死 / 水疱性類天疱瘡 / IL-6 / BP180 / エンドサイトーシス / NF-kappaBシグナル Less

複雑化直鎖状ユビキチンコードを介した炎症・免疫制御の包括的研究Principal InvestigatorOngoing
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Osaka City University
Construction of DUB MAP for innate immune and inflammatory responsesPrincipal InvestigatorOngoing
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Osaka City University
直鎖状ユビキチン鎖を介した生体防御応答の制御とその破綻に伴う疾患発症Ongoing
- Principal Investigator
  
  及川大輔
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Osaka City University
水疱性類天疱瘡における炎症誘起機序の解明と新たな治療法の開発応用Ongoing
- Principal Investigator
  
  鶴田大輔
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Osaka City University
炎症・免疫シグナル制御に関与する２種の新規ユビキチンリガーゼの解析Principal InvestigatorOngoing
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Osaka City University
Involvement of linear ubiquitination in mitophagyPrincipal Investigator
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka City University
Spatiotemporal regulation of Inflammation and immune signals by ubiquitination and its mathematical simulationOngoing
- Principal Investigator
  
  井上純一郎
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Identification of deubiquitinases, which regulate inflammatory and immune signaling pathways, and screening for their inhibitorsPrincipal Investigator
- Principal Investigator
  
  TOKUNAGA Fuminori
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka City University
Regulation of cellular signal transduction by novel immunological factor
- Principal Investigator
  
  Oikawa Daisuke
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka City University
  Gunma University
新規LUBAC結合性ユビキチンリガーゼの機能解析Principal Investigator
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka City University
  Gunma University
Screening for interactors of linear ubiquitin chain assembly complex (LUBAC), and studies on their physiological functionsPrincipal Investigator
- Principal Investigator
  
  TOKUNAGA Fuminori
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka City University
  Gunma University
Construction and application of linear ubiquitin-specific molecular probes for anti-cancer drug screeningPrincipal Investigator
- Principal Investigator
  
  TOKUNAGA Fuminori
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Gunma University
Investigation of physiological function of linear polyubiquitination using various biological modelsPrincipal Investigator
- Principal Investigator
  
  TOKUNAGA Fuminori
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Gunma University
Construction of polyubiquitin chain specific molecular probes and their applications to histopathologic examinations.Principal Investigator
- Principal Investigator
  
  TOKUNAGA Fuminori
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Gunma University
p97-ユビキチンリガーゼ複合体のタンパク質品質管理への関与Principal Investigator
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Regulation of Signal Transduction by Post-translational Modifications and Its Pathogenic Dysregulation
- Principal Investigator
  
  INOUE Jun-ichiro
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Studies on novel NF-kB activation mechanism through linear ubiquitination and its related disordersPrincipal Investigator
- Principal Investigator
  
  TOKUNAGA Fuminori
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
  Osaka University
炎症及び発癌機構の解明を目指した直鎖状ポリユビキチン鎖検出系の構築Principal Investigator
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
PUBドメイン含有ユビキチンリガーゼの品質管理における役割Principal Investigator
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Relationship between inflammation and novel NF-κB activation pathway which is regulated by ubiquitin systemPrincipal Investigator
- Principal Investigator
  
  TOKUNAGA Fuminori
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
炎症性疾患の治療を目指したポリユビキチン鎖生成の高感度リアルタイム検出法の開発Principal Investigator
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
  Osaka City University
Mechanism underlying selective substrate recognition by the ubiquitin system
- Principal Investigator
  
  IWAI Kazuhiro
- Project Period (FY)
  2006 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
  Osaka City University
新規RING型ユビキチンリガーゼ複合体のタンパク質品質管理における役割Principal Investigator
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka City University
Involvement of ubiquitin system on the hepatitis B virus X protein (HBx)-mediated transactivation activityPrincipal Investigator
- Principal Investigator
  
  TOKUNAGA Fuminori
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka City University
酸化修飾認識ユビキチンリガーゼ(HOIL-1)のタンパク質品質管理における役割Principal Investigator
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka City University
Effects of HOIL-1 ubiquitin ligase complex on the physiological function of hepatitis B virus X proteinPrincipal Investigator
- Principal Investigator
  
  TOKUNAGA Fuminori
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka City University
Studies on cellular basis of the endoplasmic reticulum-associated degradation and intracellular aggregation of misfolded proteinsPrincipal Investigator
- Principal Investigator
  
  TOKUNAGA Fuminori
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka City University
  Himeji Institute of Technology
分泌蛋白質の品質管理機構としての小胞体内蛋白分解メカニズムの解析
- Principal Investigator
  
  小出武比古
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Himeji Institute of Technology
小胞体の品質管理機構に関与する分子シャペロンの解析Principal Investigator
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Himeji Institute of Technology
Analysis of Structure and Function of Proteasome Derived from Rat Liver Microsome
- Principal Investigator
  
  KOIDE Takehiko
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Himeji Institute of Technology
Collaborative Research on Quality Control Mechanism of Newly Synthesized Proteins
- Principal Investigator
  
  KOIDE Takehiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Functional biochemistry
- Research Institution
  Himeji Institute of Technology
分泌蛋白質の品質管理機構としての小胞体内蛋白分解メカニズムの解析
- Principal Investigator
  
  小出武比古
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Himeji Institute of Technology
品質管理機構の担い手としての小胞体内シャペロンの解析Principal Investigator
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Himeji Institute of Technology
小胞体の品質管理に寄与する分子シャペロンと基質蛋白の糖鎖プロセッシングの重要性Principal Investigator
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Himeji Institute of Technology
分泌蛋白質の品質管理機構としての小胞体内蛋白分解メカニズムの解析
- Principal Investigator
  
  小出武比古
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Himeji Institute of Technology
品質管理機構の担い手としての小胞体内シャペロンの解析Principal Investigator
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Himeji Institute of Technology
分泌蛋白質の品質管理機構としての小胞体内蛋白分解メカニズムの解析
- Principal Investigator
  
  KOIDE Takehiko
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Himeji Institute of Technology
Identification of Proteins Associated with the Intracellular Degradation of Misfolded Clotting FactorsPrincipal Investigator
- Principal Investigator
  
  TOKUNAGA Fuminori
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Himeji Institute of Technology
プロテインCをモデルとした異常タンパク質の分泌障害と細胞内分解の解析Principal Investigator
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Himeji Institute of Technology
血液凝固因子をモデルとしたタンパク質の細胞内移行障害の分子細胞生物学的研究Principal Investigator
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Himeji Institute of Technology
網膜色素上皮細胞由来マルチプロテアーゼインヒビターの精製と生理機能解析Principal Investigator
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Himeji Institute of Technology
Analyzes of Molecular Mechanism of Protein Secretion Using Abnormal Protein C as a Model Protein
- Principal Investigator
  
  KOIDE Takehiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Himeji Institute of Technology
Mechanism of Hemolymph Coagulation System in Invertebrates
- Principal Investigator
  
  IWANAGA Sadaaki
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  Kyushu University
Molecular Genetic Studies of Thrombosis
- Principal Investigator
  
  KOIDE Takehiko
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Himeji Institute of Technology
  Niigata University
Initiation Mechanism of Extrinsic Blood Coagulation System
- Principal Investigator
  
  IWANAGA Sadaaki
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyushu University

[Book] Protein modifications in pathogenic dysregulation of signaling2015
- Author(s)
  Tokunaga F
- Total Pages
  348
- Publisher
  Springer
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Book] Protein modifications in pathogenic dysregulation of signaling2015
- Author(s)
  Tokunaga F
- Total Pages
  348
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15H04694
[Book] 次世代シグナル伝達研究 -先駆的基礎解析と臨床・創薬への展開 -2013
- Author(s)
  櫻井宏明,徳永文稔
- Publisher
  生化学
- Data Source
  KAKENHI-PROJECT-23390070
[Book] 直鎖状ユビキチン化を介したNF-κB制御機構と疾患2013
- Author(s)
  徳永文稔
- Publisher
  生化学
- Data Source
  KAKENHI-PROJECT-23390070
[Book] NF-B経路の多様なポリユビキチン鎖による制御と疾患2012
- Author(s)
  徳永文稔
- Publisher
  実験医学増刊号
- Data Source
  KAKENHI-PROJECT-23657075
[Book] シグナル伝達研究最前線20122012
- Author(s)
  徳永文稔
- Total Pages
  222
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23657075
[Book] シグナル伝達研究最前線20122012
- Author(s)
  徳永文稔
- Total Pages
  222
- Publisher
  羊土社
- Data Source
  KAKENHI-PLANNED-22117006
[Book] NF-κB経路の多様なポリユビキチン鎖による制御と疾患実験医学増刊号2012
- Author(s)
  徳永文稔
- Data Source
  KAKENHI-PROJECT-23390070
[Book] シグナル伝達研究最前線20122012
- Author(s)
  徳永文稔
- Total Pages
  222
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23390070
[Book] 新規直鎖状ポリユビキチン鎖生成によるNF-Bシグナル制御2011
- Author(s)
  徳永文稔、岩井一宏
- Publisher
  実験医学
- Data Source
  KAKENHI-PROJECT-23657075
[Book] 新規直鎖状ポリユビキチン鎖生成によるNF-κBシグナル制御実験医学2011
- Author(s)
  徳永文稔,岩井一宏
- Data Source
  KAKENHI-PROJECT-23390070
[Book] アグリソーム他6項目,キーワード:蛋白質の一生(遠藤斗志也, 小椋光, 永田和宏, 森和俊, 田口英樹,吉田賢右(編))2008
- Author(s)
  徳永文稔
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-20390097
[Book] 実験医学増刊細胞内タンパク質の社会学2005
- Author(s)
  徳永文稔
- Total Pages
  208
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17028048
[Book] 実験医学増刊細胞内タンパク質の社会学2005
- Author(s)
  徳永文稔
- Total Pages
  208
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17590274
[Journal Article] Development and application of a protein array of human deubiquitinating enzyme2020
- Author(s)
  高橋宏隆、山中聡士、徳永文稔、澤崎達也
- Journal Title
  
  生化学
  
  Volume: 92 Issue: 1 Pages: 64-74
- DOI
  10.14952/SEIKAGAKU.2020.920064
- ISSN
  0037-1017
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22541, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-19H05292, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-17K07261
[Journal Article] Subquinocin. a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling.2020
- Author(s)
  Yamanaka S, Sato Y, Oikawa D, Goto E, Fukai S, Tokunag F, Sawasaki T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 524 Issue: 1 Pages: 1-7
- DOI
  10.1016/j.bbrc.2019.12.049
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06967, KAKENHI-PROJECT-19K22541, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PLANNED-18H05501, KAKENHI-PUBLICLY-19H05292, KAKENHI-PUBLICLY-19H05296, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-17K07261, KAKENHI-PROJECT-16H06276
[Journal Article] Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.2020
- Author(s)
  Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F.
- Journal Title
  
  Communications Biology
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-18K06967
[Journal Article] Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.2020
- Author(s)
  Oikawa Daisuke、Sato Yusuke、Ohtake Fumiaki、Komakura Keidai、Hanada Kazuki、Sugawara Koji、Terawaki Seigo、Mizukami Yukari、Phuong Hoang T.、Iio Kiyosei、Obika Shingo、Fukushi Masaya、Irie Takashi、Tsuruta Daisuke、Sakamoto Shinji、Tanaka Keiji、Saeki Yasushi、Fukai Shuya、Tokunaga Fuminori
- Journal Title
  
  Commun Biol
  
  Volume: 3 Pages: 163-163
- DOI
  10.1038/s42003-020-0882-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06937, KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-19K22968, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-18H05501, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-17K19560
[Journal Article] Involvement of linear ubiquitination in neurodegenerative diseases and development of LUBAC inhibitors2020
- Author(s)
  及川大輔、伊東秀文、徳永文稔
- Journal Title
  
  生化学
  
  Volume: 92 Issue: 1 Pages: 28-34
- DOI
  10.14952/SEIKAGAKU.2020.920028
- ISSN
  0037-1017
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06967, KAKENHI-PROJECT-19K22541, KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-19H05296, KAKENHI-PROJECT-18H02619
[Journal Article] 創薬を見据えた直鎖状ユビキチン鎖生成酵素(LUBAC)阻害剤開発2020
- Author(s)
  徳永文稔
- Journal Title
  
  FARUAW
  
  Volume: 56 Issue: 1 Pages: 26-30
- DOI
  10.14894/faruawpsj.56.1_26
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22541, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-18H02619
[Journal Article] The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD.2019
- Author(s)
  Uematsu Atsushi、Kido Kohki、Takahashi Hirotaka、Takahashi Chikako、Yanagihara Yuta、Saeki Noritaka、Yoshida Shuhei、Maekawa Masashi、Honda Mamoru、Kai Tsutomu、Shimizu Kouhei、Higashiyama Shigeki、Imai Yuuki、Tokunaga Fuminori、Sawasaki Tatsuya
- Journal Title
  
  J Biol Chem.
  
  Volume: 294 Pages: 14135-14148
- DOI
  10.1074/jbc.ra119.010119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-19K16015, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-19H05292, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-17K07261
[Journal Article] Identification of linear polyubiquitin chain immunoreactivity in tau pathology of Alzheimer’s disease2019
- Author(s)
  Nakayama Yoshiaki、Sakamoto Shinji、Tsuji Kazumi、Ayaki Takashi、Tokunaga Fuminori、Ito Hidefumi
- Journal Title
  
  Neuroscience Letters
  
  Volume: 703 Pages: 53-57
- DOI
  10.1016/j.neulet.2019.03.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-18H02743, KAKENHI-PROJECT-16K18383, KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-19K16277, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-16K09729
[Journal Article] Linear Polyubiquitin Chain Modification of TDP-43-Positive Neuronal Cytoplasmic Inclusions in Amyotrophic Lateral Sclerosis2019
- Author(s)
  Nakayama Yoshiaki、Tsuji Kazumi、Ayaki Takashi、Mori Megumi、Tokunaga Fuminori、Ito Hidefumi
- Journal Title
  
  Journal of Neuropathology & Experimental Neurology
  
  Volume: 79 Pages: 256-265
- DOI
  10.1093/jnen/nlz135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-19K16277, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-18H02743, KAKENHI-PROJECT-16K09729
[Journal Article] Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-кBsignaling2019
- Author(s)
  Katsuya K, Oikawa D, Iio K, Obika S, Hori Y, Urashima T, Ayukawa K, Tokunaga F.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 509 Issue: 3 Pages: 700-706
- DOI
  10.1016/j.bbrc.2018.12.164
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-16H06276
[Journal Article] High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System2018
- Author(s)
  Katsuya K, Hori Y, Oikawa D, Yamamoto T, Umetani K, Urashima T, Kinoshita T, Ayukawa K, Tokunaga F, Tamaru M.
- Journal Title
  
  SLAS Discovery
  
  Volume: 23 Issue: 10 Pages: 1018-1029
- DOI
  10.1177/2472555218793066
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-16H06276
[Journal Article] Generation of rat monoclonal antibodies against a deubiquitinase, ovarian tumor domain-containing protein 12018
- Author(s)
  Oikawa D, Shiota M, Wanibuchi H. Tokunaga F.
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: 37 Issue: 4 Pages: 180-184
- DOI
  10.1089/mab.2018.0023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09162, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-16H06276
[Journal Article] Generation of rat monoclonal antibodies specific for DZIP3.2018
- Author(s)
  Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.
- Journal Title
  
  Monoclon. Antib. Immunodiagn. Immunother.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06575
[Journal Article] In-frame VIn-frame Val216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response.2018
- Author(s)
  Hattori M, Ishikawa O, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki S, Wakamatsu K, Tokunaga F, Shimizu A
- Journal Title
  
  J. Dermatol. Sci.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04694
[Journal Article] In-frame VIn-frame Val216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response.2018
- Author(s)
  Hattori M, Ishikawa O, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki S, Wakamatsu K, Tokunaga F, Shimizu A
- Journal Title
  
  J. Dermatol. Sci.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15210
[Journal Article] Generalized verrucosis caused by various human papillomavirus in a patient with GATA2 deficiency.2018
- Author(s)
  Kuriyama Y, Hattori M, Mitsui T, Nakano H, Tokunaga F, Oikawa D, Ishikawa O, Shimizu A.
- Journal Title
  
  J Dermatol.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08259
[Journal Article] Generation of Rat Monoclonal Antibodies Specific for DZIP3.2018
- Author(s)
  Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.
- Journal Title
  
  Monoclon Antib Immunodiagn Immunother.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08259
[Journal Article] In-frame Val216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response.2018
- Author(s)
  Hattori M, Ishikawa O, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki S, Wakamatsu K, Tokunaga F, Shimizu A.
- Journal Title
  
  J Dermatol Sci.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08259
[Journal Article] Mechanistic insight into the repigmentation of piebaldism: functional characterization of a mutant KIT in melanocyte regeneration.2018
- Author(s)
  Hattori M, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki S, Wakamatsu K, Tokunaga F, Ishikawa O, Shimizu A.
- Journal Title
  
  J. Dermatol.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04694
[Journal Article] Generation of rat monoclonal antibodies specific for DZIP32018
- Author(s)
  Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: 37 Issue: 3 Pages: 153-157
- DOI
  10.1089/mab.2018.0005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09162, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-16H06276
[Journal Article] In-frame Val216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response.2018
- Author(s)
  Hattori M, Ishikawa O, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki SI, Wakamatsu K, Tokunaga F, Shimizu A
- Journal Title
  
  J. Dermatol. Sci.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06575
[Journal Article] Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase l.2018
- Author(s)
  Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Ishitani R, Tokunaga F, Kasuya G, Nureki O.
- Journal Title
  
  Nat Commun.
  
  Volume: 9 Pages: 4424-4424
- DOI
  10.1038/s41467-018-06922-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06574, KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-17H05592, KAKENHI-PROJECT-17H03640, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H02384
[Journal Article] Mechanistic insight into the repigmentation of piebaldism: functional characterization of a mutant KIT in melanocyte regeneration.2018
- Author(s)
  Hattori M, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki S, Wakamatsu K, Tokunaga F, Ishikawa O, Shimizu A.
- Journal Title
  
  J. Dermatol.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Journal Article] Mechanistic insight into the repigmentation of piebaldism: functional characterization of a mutant KIT in melanocyte regeneration.2018
- Author(s)
  Hattori M, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki S, Wakamatsu K, Tokunaga F, Ishikawa O, Shimizu A.
- Journal Title
  
  J. Dermatol.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15210
[Journal Article] In-frame Va1216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response2018
- Author(s)
  Hattori M, Ishikawa O. Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki SI, Wakamatsu K, Tokunaga F, Shimizu A.
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 91 Issue: 1 Pages: 35-42
- DOI
  10.1016/j.jdermsci.2018.03.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07301, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-16H06276
[Journal Article] Generalized verrucosis caused by various human papillomaviruses in a patient with GATA2 deficiency2018
- Author(s)
  Kuriyama Yuko、Hattori Mai、Mitsui Takeki、Nakano Hajime、Oikawa Daisuke、Tokunaga Fuminori、Ishikawa Osamu、Shimizu Akira
- Journal Title
  
  The Journal of Dermatology
  
  Volume: -
- DOI
  10.1111/1346-8138.14149
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01192, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-16K15210, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-18H02619
[Journal Article] Mechanistic insight into the repigmentation of piebaldism: functional characterization of a mutant KIT in melanocyte regeneration.2018
- Author(s)
  Hattori M, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki S, Wakamatsu K, Tokunaga F, Ishikawa O, Shimizu A.
- Journal Title
  
  J. Dermatol.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06575
[Journal Article] In-frame VIn-frame Val216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response.2018
- Author(s)
  Hattori M, Ishikawa O, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki S, Wakamatsu K, Tokunaga F, Shimizu A
- Journal Title
  
  J. Dermatol. Sci.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Journal Article] Generation of rat monoclonal antibodies specific for DZIP3.2018
- Author(s)
  Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.
- Journal Title
  
  Monoclon. Antib. Immunodiagn. Immunother.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15210
[Journal Article] Generation of rat monoclonal antibodies specific for DZIP3.2018
- Author(s)
  Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.
- Journal Title
  
  Monoclon. Antib. Immunodiagn. Immunother.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Journal Article] Generation of rat monoclonal antibodies specific for DZIP3.2018
- Author(s)
  Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.
- Journal Title
  
  Monoclon. Antib. Immunodiagn. Immunother.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04694
[Journal Article] Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP.2017
- Author(s)
  Goto E and Tokunaga F.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 485 Pages: 152-159
- DOI
  10.1016/j.bbrc.2017.02.040
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-16K15210
[Journal Article] HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Metl-linked hybrid polyubiquitin chains.2017
- Author(s)
  Shibata, Y., Tokunaga, F., Goto, E., Komatsu, G., Gohda, J., Saeki, Y., Tanaka, K., Takahashi, H., Sawasaki, T., Inoue, S., Oshiumi, H., Seya, T., Nakano, H., Tanaka, Y., Iwai, K., and Inoue, JI.
- Journal Title
  
  PLoS Pathog.
  
  Volume: 13 Issue: 12
- DOI
  10.1371/journal.ppat.1006162
- NAID
  120005980879
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-15H01553, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PLANNED-24112002, KAKENHI-PLANNED-24112008, KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-26290036, KAKENHI-PROJECT-15K15353, KAKENHI-PROJECT-15K18468, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K01378, KAKENHI-PROJECT-16K15210, KAKENHI-PROJECT-26000014
[Journal Article] Reduced SHARPIN and LUBAC Formation May Contribute to CCl4-or Acetaminophen-Induced Liver Cirrhosis in Mice2017
- Author(s)
  Yamamotoya T, Nakatsu Y, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, and Sakoda H.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 18 Pages: 326-326
- DOI
  10.3390/ijms18020326
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-15H06427, KAKENHI-PROJECT-16J09463, KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-16K15210, KAKENHI-PROJECT-16K09784
[Journal Article] Endoplasmic reticulum stress in the pathogenesis of pretibial dystrophic epidermolysis bullosa.2017
- Author(s)
  Hattori M, Shimuzu A, Oikawa D, Kamei K, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Tokunaga F, and Ishikawa O.
- Journal Title
  
  Br J Dermatol.
  
  Volume: 印刷中
- DOI
  10.1111/bjd.15342
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-16K15210, KAKENHI-PROJECT-15K08259, KAKENHI-PROJECT-15K09739
[Journal Article] Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide.2016
- Author(s)
  Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F, and Nureki O.
- Journal Title
  
  Scientific Reports.
  
  Volume: 6 Pages: 34756-34756
- DOI
  10.1038/srep34756
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-15K08259, KAKENHI-PROJECT-16K15210
[Journal Article] Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis2016
- Author(s)
  Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, and Tokunaga F.
- Journal Title
  
  Nat Commun
  
  Volume: 7 Pages: 12547-12547
- DOI
  10.1038/ncomms12547
- NAID
  120006323739
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-15K18468, KAKENHI-PROJECT-15K08259, KAKENHI-PROJECT-16K15210, KAKENHI-PROJECT-16K18383
[Journal Article] A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.2015
- Author(s)
  Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsunomiya A, Watanabe T, Yamaoka S
- Journal Title
  
  Leukemia
  
  Volume: 30 Pages: 716-726
- DOI
  10.1038/leu.2015.267
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01172, KAKENHI-PROJECT-15H04694
[Journal Article] Mechanisms of dual specificity for M1- and K63-linked polyubiquitin chains revealed by CYLD deubiquitinase structures in catalytic states2015
- Author(s)
  Sato, Y., Goto, E., Shibata, Y., Kubota, Y., Yamagata, A., Goto-Ito, S., Kubota, K., Inoue, J., Takekawa, M., Tokunaga, F. and Fukai, S.
- Journal Title
  
  Nat Struct Mol Biol.
  
  Volume: 22 Pages: 222-222
- DOI
  10.1038/nsmb.2970
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-22117001, KAKENHI-PLANNED-22117003, KAKENHI-PLANNED-22117006, KAKENHI-PLANNED-22121003, KAKENHI-PROJECT-24247014, KAKENHI-PROJECT-24390079, KAKENHI-PROJECT-24570126, KAKENHI-PROJECT-24687012, KAKENHI-PUBLICLY-25112505, KAKENHI-PUBLICLY-25117711, KAKENHI-PROJECT-25650003, KAKENHI-PROJECT-25670137, KAKENHI-PROJECT-26840062, KAKENHI-PROJECT-15K08259, KAKENHI-PLANNED-22117002
[Journal Article] An Autosomal Recessive Mutation of DSG4 Causes Monilethrix through the ER Stress Response2015
- Author(s)
  Madoka Kato, Akira Shimizu, Yoko Yokoyama, Kyoichi Kaira, Yutaka Shimomura, Akemi Ishida-Yamamoto, Kiyoko Kamei, Fuminori Tokunaga, and Osamu Ishikawa
- Journal Title
  
  J Invest Dermatol
  
  Volume: 135 Pages: 1253-1260
- DOI
  10.1038/jid.2015.12
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22117006, KAKENHI-PROJECT-24591620, KAKENHI-PROJECT-25670137, KAKENHI-PUBLICLY-15H01172, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-25461683
[Journal Article] LUBAC formation is impaired in the livers of mice with MCD-dependent non-alcoholic steatohepatitis2015
- Author(s)
  Matsunaga Y, Nakatsu Y, Fukushima T, Okubo H, Iwashita M, Sakoda H, Fujishiro M, Yamamotoya T, Kushiyama A, Takahashi S, Tsuchiya Y, Kamata H, Tokunaga F, Iwai K, Asano T.
- Journal Title
  
  Mediators of Inflammation
  
  Volume: 2015 Pages: 10-10
- DOI
  10.1155/2015/125380
- NAID
  120005745641
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08259, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-26670154, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-25253019
[Journal Article] The Structural differences between a glycoprotein specific F-box protein Fbsl and its homologous protein FBG32015
- Author(s)
  Kumanomidou, T., Nishio, K., Takagi, K., Nakagawa, T., Suzuki, A., Yamane, T., Tokunaga, F., Iwai, K., Murakami, A., Yoshida, Y., Tanaka, K., and Mizushima, T.
- Journal Title
  
  PRoS ONE
  
  Volume: 10
- DOI
  10.1371/journal.pone.0140366
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08259, KAKENHI-PUBLICLY-15H01172, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25253019
[Journal Article] 8番目のユビキチン鎖、直鎖状ユビキチン鎖の機能と疾患への関わり：炎症、免疫応答に重要なNF-κB経路の新しい制御機構2014
- Author(s)
  徳永文稔
- Journal Title
  
  化学と生物
  
  Volume: 52 Pages: 716-718
- Data Source
  KAKENHI-PLANNED-22117006
[Journal Article] 8番目のユビキチン鎖、直鎖状ユビキチン鎖の機能と疾患への関わり：炎症、免疫応答に重要なNF-κB経路の新しい制御機構2014
- Author(s)
  徳永文稔
- Journal Title
  
  化学と生物
  
  Volume: 52 Pages: 716-718
- Data Source
  KAKENHI-PROJECT-25670137
[Journal Article] Structural and functional analyses of DNA-sensing and immune activation by human cGAS2013
- Author(s)
  Kazuki Kato, Ryohei Ishii, Eiji Goto, Ryuichiro Ishitani, Fuminori Tokunaga, and Osamu Nureki
- Journal Title
  
  PLoS One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390070
[Journal Article] 直鎖状ユビキチン化を介したNF-κB制御機構と疾患2013
- Author(s)
  徳永文稔
- Journal Title
  
  生化学
  
  Volume: 85 Pages: 414-422
- NAID
  10031184261
- Data Source
  KAKENHI-PLANNED-22117006
[Journal Article] Structural and functional analyses of DNA-sensing and immune activation by human cGAS.2013
- Author(s)
  Kazuki Kato, Ryohei Ishii, Eiji Goto, Ryuichiro Ishitani, Fuminori Tokunaga, and Osamu Nureki
- Journal Title
  
  PLoS One
  
  Volume: 8
- DOI
  10.1371/journal.pone.0076983
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22117006, KAKENHI-PLANNED-22117007, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-25670137, KAKENHI-PROJECT-25860207
[Journal Article] 直鎖状ユビキチン化を介したNF-κB制御機構と疾患2013
- Author(s)
  徳永文稔
- Journal Title
  
  生化学
  
  Volume: 85 Pages: 414-422
- NAID
  10031184261
- Data Source
  KAKENHI-PROJECT-25670137
[Journal Article] 直鎖状ユビキチン化を介したNF-κB制御機構と疾患2013
- Author(s)
  徳永文稔
- Journal Title
  
  生化学
  
  Volume: 85 Pages: 414-422
- NAID
  10031184261
- Data Source
  KAKENHI-PROJECT-23390070
[Journal Article] Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin2013
- Author(s)
  Naonobu Fujita, Eiji Morita, Takashi Itoh, Atsushi Tanaka, Megumi Nakaoka, Yuki Osada, Tetsuo Umemoto, Tatsuya Saitoh, Hitoshi Nakatogawa, Shouhei Kobayashi, Tokuko Hataguchi, Jun-Lin Guan, Kazuhiro Iwai, Fuminori Tokunaga, Kazunobu Saito, Koutaro Ishibashi, Shizuo Akira, Mitsunori Fukuda, Takeshi Noda, and Tamotsu Yoshimori
- Journal Title
  
  J. Cell Biol
  
  Volume: 203 Pages: 115-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390070
[Journal Article] Linear ubiquitination-mediated NF-κB regulation and its related disorders2013
- Author(s)
  Fuminori Tokunaga
- Journal Title
  
  J. Biochem
  
  Volume: 154 Pages: 313-323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390070
[Journal Article] Linear ubiquitination-mediated NF-κB regulation and its related disorders2013
- Author(s)
  Fuminori Tokunaga
- Journal Title
  
  J. Biochem.
  
  Volume: 154 Pages: 313-323
- DOI
  10.1093/jb/mvt079
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22117006, KAKENHI-PROJECT-23390070, KAKENHI-PROJECT-25670137
[Journal Article] Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells2012
- Author(s)
  Masato Tomonaga, Nobuyuki Hashimoto, Fuminori Tokunaga, Megumi Onishi, Akira Myoui, Hideki Yoshikawa, and Kazuhiro Iwai
- Journal Title
  
  Int. J.Oncol
  
  Volume: 40 Pages: 409-417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657075
[Journal Article] Non-canonical UBA-UBL interaction mediates formation of linear ubiquitin chain assembly complex2012
- Author(s)
  Hirokazu Yagi, Kazuhiro Ishimoto, Takeshi Hiromoto, Hiroaki Fujita, Tsunehiro Mizushima, Yoshinori Uekusa, Maho Yagi-Utsumi, Eiji Kurimoto, Masanori Noda, Susumu Uchiyama, Fuminori Tokunaga, Kazuhiro Iwai, and Koichi Kato
- Journal Title
  
  EMBO Rep
  
  Volume: 13 Pages: 462-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390070
[Journal Article] Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells2012
- Author(s)
  Masato Tomonaga, Nobuyuki Hashimoto, Fuminori Tokunaga, Megumi Onishi, Akira Myoui, Hideki Yoshikawa, and Kazuhiro Iwai
- Journal Title
  
  Int. J. Oncol
  
  Volume: 40 Pages: 409-417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390070
[Journal Article] Analysis of NF-κB essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB2012
- Author(s)
  Tobias Kensche, Fuminori Tokunaga, Fumiyo Ikeda, Eiji Goto, Kazuhiro Iwai, and Ivan Dikic
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Pages: 23626-23634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657075
[Journal Article] LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses2012
- Author(s)
  Fuminori Tokunaga and Kazuhiro Iwai
- Journal Title
  
  Microbes Infect.
  
  Volume: 14 Pages: 563-572
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390070
[Journal Article] A novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex2012
- Author(s)
  Fuminori Tokunaga and Kazuhiro Iwai: Linear ubiquitination
- Journal Title
  
  Endocrine J.
  
  Volume: 59 Pages: 641-652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657075
[Journal Article] LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses.2012
- Author(s)
  Tokunaga, F., et al.
- Journal Title
  
  Microbes Infect
  
  Volume: (in press) Pages: 563-572
- DOI
  10.1016/j.micinf.2012.01.011
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22117006, KAKENHI-PROJECT-23390070, KAKENHI-PROJECT-23657075
[Journal Article] A novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex2012
- Author(s)
  Fuminori Tokunaga and Kazuhiro Iwai: Linear ubiquitination
- Journal Title
  
  Endocrine J
  
  Volume: 59 Pages: 641-652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390070
[Journal Article] Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation2012
- Author(s)
  Fuminori Tokunaga, Hiroshi Nishimasu, Ryuichiro Ishitani, Eiji Goto, Takuya Noguchi, Kazuhiro Mio, Kiyoko Kamei, Averil Ma, Kazuhiro Iwai, and Osamu Nureki
- Journal Title
  
  EMBO J
  
  Volume: 31 Pages: 3856-3870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657075
[Journal Article] Analysis of NF-κB essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB2012
- Author(s)
  Tobias Kensche, Fuminori Tokunaga, Fumiyo Ikeda, Eiji Goto, Kazuhiro Iwai, and Ivan Dikic
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Pages: 23626-23634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390070
[Journal Article] A novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex.2012
- Author(s)
  Tokunaga, F.
- Journal Title
  
  Endocr. J.
  
  Volume: 59 Pages: 641-652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390070
[Journal Article] Backbone and side chain ^1H, ^<13>C, and ^<15> N assignments of ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex2012
- Author(s)
  Yoshinori Uekusa, Syunsuke Miura, Hiroaki Sasakawa, Eiji Kurimoto, Eri Sakata, Serve Oliver, Hirokazu Yagi, Fuminori Tokunaga, Kazuhiro Iwai, and Koichi Kato
- Journal Title
  
  Biomol. NMR Assign
  
  Volume: 6 Pages: 177-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390070
[Journal Article] A novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex.2012
- Author(s)
  Tokunaga, F.
- Journal Title
  
  Endocr. J.
  
  Volume: 59 Pages: 641-652
- Data Source
  KAKENHI-PLANNED-22117006
[Journal Article] Backbone and side chain 1H, 13C, and 15N assignments of ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex2012
- Author(s)
  Yoshinori Uekusa, Syunsuke Miura, Hiroaki Sasakawa, Eiji Kurimoto, Eri Sakata, Serve Oliver, Hirokazu Yagi, Fuminori Tokunaga,Kazuhiro Iwai, and Koichi Kato
- Journal Title
  
  Biomol. NMR Assign.
  
  Volume: 6 Pages: 177-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657075
[Journal Article] Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation.2012
- Author(s)
  Tokunaga F, Nishimasu H, Ishitani R, Goto E, Noguchi T, Mio K, Kamei K, Ma A, Iwai K, Nureki O
- Journal Title
  
  EMBO J
  
  Volume: 31 Pages: 3856-3856
- DOI
  10.1038/emboj.2012.241
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22117007, KAKENHI-PROJECT-22249008, KAKENHI-PROJECT-22687007, KAKENHI-PROJECT-23390070, KAKENHI-PROJECT-23591263, KAKENHI-PROJECT-23657075, KAKENHI-PROJECT-23687014, KAKENHI-PROJECT-23700517, KAKENHI-PROJECT-24659136, KAKENHI-PLANNED-22117006, KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002
[Journal Article] A novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex.2012
- Author(s)
  Tokunaga, F.
- Journal Title
  
  Endocr. J.
  
  Volume: 59 Pages: 641-652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657075
[Journal Article] Non-canonical UBA-UBL interaction mediates formation of linear ubiquitin chain assembly complex2012
- Author(s)
  Hirokazu Yagi, Kazuhiro Ishimoto, Takeshi Hiromoto, Hiroaki Fujita, Tsunehiro Mizushima, Yoshinori Uekusa, Maho Yagi-Utsumi, Eiji Kurimoto, Masanori Noda, Susumu Uchiyama, Fuminori Tokunaga, Kazuhiro Iwai, and Koichi Kato
- Journal Title
  
  EMBO Rep
  
  Volume: 13 Pages: 462-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657075
[Journal Article] LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses2012
- Author(s)
  Fuminori Tokunaga and Kazuhiro Iwai
- Journal Title
  
  Microbes Infect.
  
  Volume: 14 Pages: 563-572
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657075
[Journal Article] Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation2012
- Author(s)
  Fuminori Tokunaga, Hiroshi Nishimasu, Ryuichiro Ishitani, Eiji Goto, Takuya Noguchi, Kazuhiro Mio, Kiyoko Kamei, Averil Ma, Kazuhiro Iwai, and Osamu Nureki
- Journal Title
  
  EMBO J.
  
  Volume: 31 Pages: 3856-3870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390070
[Journal Article] SHARPIN is a component of the NF-κB activating linear ubiquitin assembly complex2011
- Author(s)
  Fuminori Tokunaga, Tomoko Nakagawa, Masaki Nakahara, Yasushi Saeki, Masami Taniguchi, Shin-ichi Sakata, Keiji Tanaka, Hiroyasu Nakano, and Kazuhiro Iwai
- Journal Title
  
  Nature
  
  Volume: 471 Pages: 633-636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390070
[Journal Article] SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.2011
- Author(s)
  Ikeda, F., Deribe, Y.L., Skanland, S.S., Stieglitz, B., Grabbe, C., Franz-Wachtel, M., van Wijk, S.J.L., Goswami, P., Nagy, V., Terzic, J., Tokunaga, F., Androulidaki, A., Nakagawa, T., Pasparakis, M., Iwai, K., Sundberg, J.P., Rittinger, K., Schaefer, L., Macek, B., Dikic, I.
- Journal Title
  
  Nature 471
  
  Pages: 637-641
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Sharpin is a component of the NF-κB activating linear ubiquitin assembly complex.2011
- Author(s)
  Fuminori Tokunaga, et al.
- Journal Title
  
  Nature
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] SHARPIN is a component of the NF-κB activating linear ubiquitin assembly complex2011
- Author(s)
  Tokunaga, F., Nakagawa, T., Nakahara, M., Saeki, Y., Taniguchi, M., Sakata, S., Tanaka, K., Nakano, H., Iwai, I.
- Journal Title
  
  Nature
  
  Volume: 471 Pages: 633-636
- DOI
  10.1038/nature09815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-22117006, KAKENHI-PUBLICLY-23117717, KAKENHI-PROJECT-23657075, KAKENHI-PROJECT-23659404
[Journal Article] Sharpin is a component of the NF-κB activating linear ubiquitin chain assembly complex.2011
- Author(s)
  Tokunaga, F., Nakagawa T., Nakahara, M., Saeki, Y., Taniguchi, M., Sakata, S.-I., Tanaka, K., Nakano, H., Iwai, K.
- Journal Title
  
  Nature
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type-I interferon induction.2011
- Author(s)
  Inn, K.-S., Gack, M.U. Tokunaga, F., Shi, M., Wong, L.-Y., Iwai, K., (責任者著), Jung, J.U.
- Journal Title
  
  Molecular Cell
  
  Volume: 41 Pages: 354-365
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction.2011
- Author(s)
  Inn K.S., Gack M.U., Tokunaga F., Shi M., Wong L.Y., Iwai K., Jung J.U.
- Journal Title
  
  Mol Cell 41
  
  Pages: 354-365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] SHARPIN is a component of the NF-κB activating linear ubiquitin assembly complex2011
- Author(s)
  Fuminori Tokunaga, Tomoko Nakagawa, Masaki Nakahara, Yasushi Saeki, Masami Taniguchi, Shin-ichi Sakata, Keiji Tanaka, Hiroyasu Nakano, and Kazuhiro Iwai
- Journal Title
  
  Nature
  
  Volume: 471 Pages: 633-636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657075
[Journal Article] SHARPIN is a component of the NF-κB activating linear ubiquitin chain assembly complex.2011
- Author(s)
  Tokunaga, F., Nakagawa, T., Nakahara, M., Saeki, Y., Taniguchi, M., Sakata, S.-I., Tanaka, K., Nakano, H., Iwai, K.
- Journal Title
  
  Nature 471
  
  Pages: 633-636
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] SHARPIN is a component of the NF-kB activating linear ubiquitin assembly complex.2011
- Author(s)
  Tokunaga F., Nakagawa T., Nakahara M., Saeki Y., Taniguchi M., S Sakata S.-i., Tanaka K., Nakano H., Iwai K.
- Journal Title
  
  Nature 471
  
  Pages: 633-636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis2011
- Author(s)
  Fumiyo Ikeda, Yonathan Lissanu Deribe, Sigrid S. Skånland, Benjamin Stieglitz, Caroline Grabbe, Sjoerd van WijK, Mirita Franz-Wachtel, Panchali Goswami, Vanja Nagy, Janos Terzic, Fuminori Tokunaga, Ariadne Androulidaki, Tomoko Nakagawa, Manolis Pasparakis, Kazuhiro Iwai, John P. Sundberg, Liliana Schaefer, Boris Macek, Katrin Rittinger, and Ivan Dikic
- Journal Title
  
  Nature
  
  Volume: 471 Pages: 637-641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390070
[Journal Article] Linear ubiquitin assembly complex negativelyregulates RIG-I- and TRIM25-mediated type I interferon induction2011
- Author(s)
  Kyung-Soo Inn, Michaela U. Gack, Fuminori Tokunaga, Mude Shi, Lai-Yee Wong, Kazuhiro Iwai, and Jae U. Jung
- Journal Title
  
  Mol. Cell
  
  Volume: 41 Pages: 354-365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657075
[Journal Article] Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction2011
- Author(s)
  Kyung-Soo Inn, Michaela U. Gack, Fuminori Tokunaga, Mude Shi, Lai-Yee Wong, Kazuhiro Iwai, and Jae U. Jung
- Journal Title
  
  Mol. Cell
  
  Volume: 41 Pages: 354-365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390070
[Journal Article] Sharpin is a component of the NF-κB activating linear ubiquitin assembly complex.2011
- Author(s)
  Fuminori Tokunaga, et al.
- Journal Title
  
  Nature
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21657028
[Journal Article] SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.2011
- Author(s)
  Ikeda F., Deribe Y.L, Skanland S.S., Stieglitz B., Grabbe C., van WijK S., Franz-Wachtel M., Goswami P., Nagy V., Terzic J., Tokunaga F., Androulidaki A., Nakagawa T., Pasparakis M., Iwai K., Sundberg J.P., Schaefer L., Macek B., Rittinger K., Dikic, I.
- Journal Title
  
  Nature 471
  
  Pages: 637-641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis2011
- Author(s)
  Fumiyo Ikeda, Yonathan Lissanu Deribe, Sigrid S. Skanland, Benjamin Stieglitz, Caroline Grabbe, Sjoerd van WijK, Mirita Franz-Wachtel, Panchali Goswami, Vanja Nagy, Janos Terzic, Fuminori Tokunaga, Ariadne Androulidaki, Tomoko Nakagawa, Manolis Pasparakis, Kazuhiro Iwai, John P. Sundberg, Liliana Schaefer, Boris Macek, Katrin Rittinger, and Ivan Dikic
- Journal Title
  
  Nature
  
  Volume: 471 Pages: 637-641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657075
[Journal Article] Linear ubiquitin assembly complex negatively regulates RIG-I-and TRIM25-mediated type-I interferon induction.2011
- Author(s)
  Inn, K.-S., Gack, M.U.Tokunaga, F., Shi, M., Wong, L.-Y., Iwai, K., (corresponding author) Jung, J.U.
- Journal Title
  
  Molecular Cell 41
  
  Pages: 354-365
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] ユビキチン修飾系によるNF-κBグナル伝達制御:新規直鎖状ポリユビキチン鎖形成を介するNF-κB制御機構の発見2010
- Author(s)
  徳永文稔、岩井一宏
- Journal Title
  
  細胞工学 29
  
  Pages: 1224-1230
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] ユビキチンープロテアソーム系の多彩な生理機能と疾患への関与2010
- Author(s)
  徳永文稔
- Journal Title
  
  BIO Clinica 25
  
  Pages: 1092-1097
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] Crystallization and prelimiary X-ray characterization of the Skp1-Fbg3 complex.2010
- Author(s)
  Kumanomidou T., Nakagawa T., Mizushima T., Suzoki A., Tokunaga F., Iwai K., Yoshida Y., Tanaka K., Yamane T.
- Journal Title
  
  Acta Crystallogr.Sect.F Struct.Biol.Cryst.Commun 66
  
  Pages: 95-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] Involvement of linear polyubiquitination of NEMO in NF-κB activation.2009
- Author(s)
  Tokunaga, F., Sakata, S.-I., Saeki, Y., Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Kato, M., Murata, S., Yamaoka, S., Yamamoto, M., Akira, S., Takao, T., Tanaka, K.Iwai, K.
- Journal Title
  
  Nature Cell Biology 11
  
  Pages: 123-132
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Linear polyubiquitination : a new regulator of NF-kB activation2009
- Author(s)
  Iwai K., Tokunaga F.
- Journal Title
  
  EMBO Rep. 10
  
  Pages: 706-713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059031
[Journal Article] Linear polyubiquitination : a new regulator of NF κB activation2009
- Author(s)
  Iwai K., Tokunaga F.
- Journal Title
  
  EMBO Rep. 10
  
  Pages: 706-713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21657028
[Journal Article] アレルギーやガンに関わるNF-κBの新しい活性化機構の発見:新規ユビキチン修飾2009
- Author(s)
  岩井一宏、坂田真一、中川朋子、徳永文稔
- Journal Title
  
  直鎖状ポリユビキチン化によるNF-κB活性化.化学と生物 47
  
  Pages: 602-604
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] Involvement of linear polyubiquitylation of NEMO in NF-KB activation2009
- Author(s)
  Tokunaga, F., et.al.
- Journal Title
  
  Nature Cell Biology 11
  
  Pages: 123-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059031
[Journal Article] Involvement of linear polyubiquitylation of NEMO in NF-kB activation2009
- Author(s)
  Tokunaga, F., et al.
- Journal Title
  
  Nature Cell Biology 11
  
  Pages: 123-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19657035
[Journal Article] Involvement of linear polyubiquitylation of NEMO in NF-kB activation2009
- Author(s)
  Tokunaga, F., et al.
- Journal Title
  
  Nature Cell Biology 11
  
  Pages: 123-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] Involvement of linear polyubiquitination of NEMO in NF-KB activation2009
- Author(s)
  Tokunaga, F., Sakata, S.-I., Saeki, Y.,Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Kato, M., Murata, S., Yamaoka, S., Yamamoto, M., Akira, S.,Takao, T., Tanaka, K. and lwai K.
- Journal Title
  
  Nature Cell Biology 11
  
  Pages: 123-132
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Involvement of linear polyubiquitylation of NEMO in NF-κB activation.2009
- Author(s)
  Tokunaga F., Sakata S.-i., Saeki Y., Satomi Y., Kirisako T., Kamei K., Nakagawa T., Kato M., Murata S., Yamaoka S., Yamamoto M., Akira S., Takao T., Tanaka K., Iwai K.
- Journal Title
  
  Nature Cell Biol. 11
  
  Pages: 123-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] Linear polyubiquitination : a new regulator of NF-κB activation.2009
- Author(s)
  Iwai, K., Tokunaga, F.
- Journal Title
  
  EMBO Rep 10
  
  Pages: 706-713
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Linear polyubiquitination : a new regulator of NF-kB activation.2009
- Author(s)
  岩井一宏, 徳永文稔
- Journal Title
  
  EMBO Rep. 10
  
  Pages: 706-713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] NEMOの直鎖状ポリユビキチン化修飾によるNF-κB活性化2009
- Author(s)
  徳永文稔、岩井一宏
- Journal Title
  
  蛋白質核酸酵素 54
  
  Pages: 635-642
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] Involvement of linear polyubiquitinatioh of NEMO in NF-κB activation2009
- Author(s)
  Tokunaga, F., Sakata, Saeki, Y., Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Kato,_M., Murata, S., Yamaoka, S., Yamamoto, M., Akira, S., Takao, T., Tanaka, K., and Iwai K.
- Journal Title
  
  Nature Cell Biology 11
  
  Pages: 123-132
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Linear polyubiquitination : a new regulator of NF-κB activation2009
- Author(s)
  Iwai K., Tokunaga F.
- Journal Title
  
  EMBO Rep. 10
  
  Pages: 706-713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] The COP9/signalosome increases the efficiency of pVHL ubiquitin ligase-mediated hypoxia inducible factor-α ubiquitination2008
- Author(s)
  Miyauchi, Y., Kato, M., Tokunaga, F., and Iwai, K.
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 16622-16631
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] The COP9/signalosome increases the efficiency of pVHL ubiquitin ligase.mediated hypoxia inducible factor-α ubiquitination.2008
- Author(s)
  Miyauchi, Y., Kato, M., Tokunaga, F., Iwai, K.
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 16622-16631
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] gp78 cooperates with RMA1 in ER-associadegradation of CFTRDF508.2008
- Author(s)
  Morito D., Hirao K., Oda Y., Hosokawa N., Tokunaga F., Cyr D.M., Tanaka K., Iwai K., Nagata K.
- Journal Title
  
  Mol.Biol.Cell 19
  
  Pages: 1328-1336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] The COP9/signalosome increases the efficiency of pVHL ubiquitin ligase-mediated hypoxia inducible factor-a ubiquitination2008
- Author(s)
  Miyauchi, Y., Kato, M., Tokunaga, F., Iwai, K.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 16622-16631
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] The COP9/signalosome increases the efficiency of von Hippel-Linubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination.2008
- Author(s)
  Miyauchi Y., Kato M., Tokunaga F., Iwai K.
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 1662-16631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] Gp78 Cooperates with RMA1 in ER-associated Degradation of CFTRΔF508.2008
- Author(s)
  Morito, D., Hirao, K., Oda, Y., Hosokawa, N., Tokunaga, F., Cyr, D.M., Tanaka, K., Iwai, K., Nagata K.
- Journal Title
  
  Mol.Biol.Cell. 19
  
  Pages: 1328-1336
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Herne induces ubiquitination and degradation of the transcription factor Bachl2007
- Author(s)
  Zenke-Kawasaki, Y., Dohi, Y., Katoh, Y., Ikura, T., lkura, M., Asahara, T., Tokunaga, F., Iwai, Igarashi, K.
- Journal Title
  
  Mol. Cell Biol. 27
  
  Pages: 6962-6971
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] A ubiquitin ligase complex assembles linear polyubiquitin chains.2006
- Author(s)
  Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, K., Sano, S.Tokunaga, F., Tanaka, K.Iwai, K.
- Journal Title
  
  EMBO J. 25
  
  Pages: 4877-4887
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex (LUBAC).2006
- Author(s)
  Nakamura, M., Tokunaga, F., Sakata, S.-I., Iwai, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 351・2
  
  Pages: 340-347
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex (LUBAC)2006
- Author(s)
  Nakamura, M., Tokunaga, F., Sakata , S.-I., Iwai, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 351
  
  Pages: 340-347
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] A ubiquitin ligase complex assembles linear polyubiquitin chains2006
- Author(s)
  Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, K., Sano, S. Tokunaga, F., Tanaka, K., lwai, K.
- Journal Title
  
  EMBO J. 25
  
  Pages: 4877-4887
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] A ubiquitin ligase complex assembles linear polyubiquitin chains.2006
- Author(s)
  Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, K., Sano, S., Tokunaga, F., Tanaka.K., Iwai.K.
- Journal Title
  
  EMBO J. 25・20
  
  Pages: 4877-4887
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] ユビキチンと小胞体関連分解(ERAD)2004
- Author(s)
  徳永文稔
- Journal Title
  
  医学のあゆみ 211
  
  Pages: 135-141
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590279
[Journal Article] 血液凝固因子欠乏症と蛋白質の輸送・品質管理2004
- Author(s)
  徳永文稔
- Journal Title
  
  蛋白質拡散酵素 49
  
  Pages: 1135-1135
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590279
[Journal Article] 小胞体におけるフォールディングと品質管理2004
- Author(s)
  徳永文稔
- Journal Title
  
  細胞工学 23
  
  Pages: 1384-1389
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590279
[Journal Article] Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains.2003
- Author(s)
  Yukiko Yoshida, Fuminori Tokunaga, Tomoki Chiba, Kazuhiro Iwai, Keiji Tanaka, Tadashi Tai
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 43877-43884
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590279
[Journal Article] Identification of the Ubiquitin-protein Ligase that Recognizes Oxidized IRP22003
- Author(s)
  Koji Yamanaka, Hartuto Ishikawa, Yuzuru Megumi, Fuminori Tokunaga, Masato Kanie, Tracy A.Rouault, Isao Morishima, Nagahiro Minato, Koichiro Ishimori, Kazuhiro Iwai
- Journal Title
  
  Nat.Cell Biol. 5
  
  Pages: 336-340
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590279
[Journal Article] N-Linked Oligosaccharide Processing, but not Association with Calnexin/calreticulin is Highly Correlated with Endoplasmic Reticulum-associated Degradation of Antithrombin Glu313-deleted Mutant2003
- Author(s)
  Fuminori Tokunaga, Kazuya Hara, Takehiko Koide
- Journal Title
  
  Arch.Biochem.Biophys. 411
  
  Pages: 235-243
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590279
[Journal Article] Characterization of endoplasmic reticulum-associated degradation of a protein S mutant identified in a family of quantitative protein S deficiency.
- Author(s)
  Hiroko Tsuda, Fuminori Tokunaga, Hiroshi Nagamitsu, Takehiko Koide
- Journal Title
  
  Thomb.Res. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590279
[Presentation] LUBACによるT細胞受容体シグナル制御に関する細胞・生化学及び数理モデル解析2019
- Author(s)
  及川大輔、畑中尚也、鈴木貴、徳永文稔
- Organizer
  第14回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] Hsp72によるがん細胞遊走制御2019
- Author(s)
  塩田正之、田中昌子、鰐渕英機、徳永文稔
- Organizer
  第14回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] Cellular mechanism of LUBAC-mediated NF-κB activation pathway2019
- Author(s)
  Fuminori Tokunaga
- Organizer
  1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] 自然免疫制御に関わる新規脱ユビキチン化酵素OTUD1の同定と生理機能解析2019
- Author(s)
  駒倉啓大、及川大輔、徳永文稔
- Organizer
  第24回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06967
[Presentation] LRBA DUF1088ドメインの自然免疫制御における重要性2019
- Author(s)
  及川大輔、駒倉啓大、福士雅也、入江崇、堀居拓郎、畑田出穂、阪口剛正、徳永文稔
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] Screening and analysis of novel linear polyubiquitin chain binding proteins based on wheat cell-free 20K-HUPA2019
- Author(s)
  Kazuya Nagano, Hirotaka Takahashi, Fuminori Tokunaga, Tatsuya Sawasaki
- Organizer
  1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] Subquinocin, a small moleculae inhibitor for USPs, promotes NF-κB signal by stabilization of M1-linked polyubiquitin2019
- Author(s)
  Hirotaka Takahashi, Satoshi Yamanaka, Yusuke Sato, Daisuke Oikawa, Shuya Fukai, Fuminori Tokunaga, Tatsuya Sawasaki
- Organizer
  1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] Screening and analysis of novel linear polyubiquitin chain binding proteins based on wheat cell-free 20K-HUPA2019
- Author(s)
  Kazuya Nagano, Hirotaka Takahashi, Fuminori Tokunaga, Tatsuya Sawasaki
- Organizer
  1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] 直鎖状ポリユビキチン鎖結合タンパク質ZnUBPファミリーのNF-κB抑制機構の解明2019
- Author(s)
  高橋宏隆、及川大輔、長尾和哉、岩崎誠、今井祐記、徳永文稔、澤崎達也
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] 自然免疫制御に関わる新規脱ユビキチン化酵素OTUD1の同定と生理機能解析2019
- Author(s)
  駒倉啓大、徳永文稔
- Organizer
  第24回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] OTUD1, and OTU family deubiquitinase, is involved in innate immune responses2019
- Author(s)
  Keidai Komakura, Eiji Goto, Daisuke Oikawa, Takanori Abe, Fuminori Tokunaga
- Organizer
  1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] 自然免疫制御に関わる新規脱ユビキチン化酵素OTUD1の同定と生理機能解析2019
- Author(s)
  駒倉啓大、徳永文稔
- Organizer
  第24回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-19K22541
[Presentation] Hsp72によるがん細胞遊走制御2019
- Author(s)
  塩田正之、田中昌子、鰐渕英機、徳永文稔
- Organizer
  第14回日本臨床ストレス応答学会
- Data Source
  KAKENHI-PROJECT-19K22541
[Presentation] LRBA DUF1088ドメインの自然免疫制御における重要性2019
- Author(s)
  及川大輔、駒倉啓大、福士雅也、入江崇、堀居拓郎、畑田出穂、阪口剛正、徳永文稔
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] 直鎖状ユビキチン鎖生成を介した炎症シグナル発信と疾患・創薬2019
- Author(s)
  徳永文稔
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] 直鎖状ポリユビキチン鎖結合タンパク質ZnUBPファミリーのNF-κB抑制機構の解明2019
- Author(s)
  高橋宏隆、及川大輔、長尾和哉、岩崎誠、今井祐記、徳永文稔、澤崎達也
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06967
[Presentation] 脱ユビキチン化酵素OTUD1によるNF-kB経路とインターフェロン産生経路の相反的制御2019
- Author(s)
  駒倉啓大、及川大輔、徳永文稔
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] Identification and characterization of small-molecule LUBAC inhibitors, HOIPINs2019
- Author(s)
  Daisuke Oikawa, Ken Katsuya, Kazuya Hanada, Shinji Sakamoto, Fuminori Tokunaga
- Organizer
  1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] LUBACによるT細胞受容体シグナル制御に関する細胞・生化学及び数理モデル解析2019
- Author(s)
  及川大輔、畑中尚也、鈴木貴、徳永文稔
- Organizer
  第14回日本臨床ストレス応答学会
- Data Source
  KAKENHI-PROJECT-19K22541
[Presentation] LUBACシグナルソームによる自然免疫応答の選択的制御2019
- Author(s)
  及川大輔、駒倉啓大、阿部貴則、飯尾清誠、小比賀真吾、勝矢健、花田和希、坂本信二、徳永文稔
- Organizer
  第91回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06967
[Presentation] LUBACシグナルソームによる自然免疫応答の選択的制御2019
- Author(s)
  及川大輔, 駒倉啓大, 阿部貴則, 飯尾清誠, 小比賀真吾, 勝矢健, 花田和希, 坂本信二, 徳永文稔
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] LRBA DUF1088ドメインの自然免疫制御における重要性2019
- Author(s)
  及川大輔、駒倉啓大、福士雅也、入江崇、堀居拓郎、畑田出穂、阪口剛正、徳永文稔
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22541
[Presentation] Cellular mechanism of LUBAC-mediated NF-κB activation pathway2019
- Author(s)
  Fuminori Tokunaga
- Organizer
  1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] Screening and characterization of novel LUBAC inhibitors, HOIPINs2019
- Author(s)
  Oikawa, D., Katsuya, K., Hanada, K., Sugawara, K., Tsuruta, D., Sakamoto, S., Tokunaga, F.
- Organizer
  Cold Spring Harbor Laboratory Meeting on Ubiquitin, Autophagy & Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22541
[Presentation] 直鎖状ポリユビキチン鎖結合タンパク質ZnUBPファミリーのNF-kB抑制機構の解明2019
- Author(s)
  高橋宏隆、及川大輔、長尾和哉、岩崎誠、今井祐記、徳永文稔、澤崎達也
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] 脱ユビキチン化酵素OTUD1によるNF-κB経路とインターフェロン産生経路の相反的制御2019
- Author(s)
  駒倉啓大、及川大輔、徳永文稔
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22541
[Presentation] Screening and characterization of novel LUBAC inhibitors, HOIPINs2019
- Author(s)
  Oikawa, D., Katsuya, K., Hanada, K., Sugawara, K., Tsuruta, D., Sakamoto, S., Tokunaga, F.
- Organizer
  Cold Spring Harbor Laboratory Meeting on Ubiquitin, Autophagy & Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] 脱ユビキチン化酵素OTUD1によるNF-κB経路とインターフェロン産生経路の相反的制御2019
- Author(s)
  駒倉啓大、及川大輔、徳永文稔
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06967
[Presentation] 脱ユビキチン化酵素OTUD1によるNF-κB経路とインターフェロン産生経路の相反的制御2019
- Author(s)
  駒倉啓大、及川大輔、徳永文稔
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] Stress Signaling Modules: ストレスの受容と細胞応答の選択性　LUBACシグナルソームによる自然免疫応答の選択的制御2019
- Author(s)
  及川大輔, 駒倉啓大, 阿部貴則, 飯尾清誠, 小比賀真吾, 勝矢健, 花田和希, 坂本信二, 徳永文稔
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] 直鎖状ユビキチン鎖生成を介した炎症シグナル発信と疾患・創薬2019
- Author(s)
  徳永文稔
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22541
[Presentation] 直鎖状ポリユビキチン鎖結合タンパク質ZnUBPファミリーのNF-κB抑制機構の解明2019
- Author(s)
  高橋宏隆、及川大輔、長尾和哉、岩崎誠、今井祐記、徳永文稔、澤崎達也
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22541
[Presentation] LRBA DUF1088ドメインの自然免疫制御における重要性2019
- Author(s)
  及川大輔、駒倉啓大、福士雅也、入江崇、堀居拓郎、畑田出穂、坂口剛正、徳永文稔
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06967
[Presentation] OTUD1, and OTU family deubiquitinase, is involved in innate immune responses2019
- Author(s)
  Keidai Komakura, Eiji Goto, Daisuke Oikawa, Takanori Abe, Fuminori Tokunaga
- Organizer
  1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] LUBACによるT細胞受容体シグナル制御に関する細胞・生化学及び数理モデル解析2019
- Author(s)
  及川大輔、畑中尚也、鈴木貴、徳永文稔
- Organizer
  第14日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-18K06967
[Presentation] Subquinocin, a small moleculae inhibitor for USPs, promotes NF-κB signal by stabilization of M1-linked polyubiquitin2019
- Author(s)
  Hirotaka Takahashi, Satoshi Yamanaka, Yusuke Sato, Daisuke Oikawa, Shuya Fukai, Fuminori Tokunaga, Tatsuya Sawasaki
- Organizer
  1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] Identification and characterization of small-molecule LUBAC inhibitors, HOIPINs2019
- Author(s)
  Daisuke Oikawa, Ken Katsuya, Kazuya Hanada, Shinji Sakamoto, Fuminori Tokunaga
- Organizer
  1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] 自然免疫制御に関わる新規脱ユビキチン化酵素OTUD1の同定と生理機能解析2019
- Author(s)
  駒倉啓大、徳永文稔
- Organizer
  第24回日本病態プロテアーゼ学会学術集
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] LUBACによるT細胞受容体シグナル制御に関する細胞・生化学及び数理モデル解析2019
- Author(s)
  及川大輔、畑中尚也、鈴木貴、徳永文稔
- Organizer
  第14回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] 直鎖状ユビキチン鎖生成を介した炎症シグナル発信と疾患・創薬2019
- Author(s)
  徳永文稔
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] Stress Signaling Modules: ストレスの受容と細胞応答の選択性　LUBACシグナルソームによる自然免疫応答の選択的制御2019
- Author(s)
  及川大輔, 駒倉啓大, 阿部貴則, 飯尾清誠, 小比賀真吾, 勝矢健, 花田和希, 坂本信二, 徳永文稔
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K22541
[Presentation] Hsp72によるがん細胞遊走制御2019
- Author(s)
  塩田正之、田中昌子、鰐渕英機、徳永文稔
- Organizer
  第14回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] Screening and characterization of novel LUBAC inhibitors, HOIPINs2019
- Author(s)
  Oikawa, D., Katsuya, K., Hanada, K., Sugawara, K., Tsuruta, D., Sakamoto, S., Tokunaga, F.
- Organizer
  Cold Spring Harbor Laboratory Meeting on Ubiquitin, Autophagy & Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] TCRシグナルにおける直鎖状ユビキチン化の数理モデル解析2018
- Author(s)
  後藤栄治、浜田大輔、及川大輔、鈴木貴、徳永文稔
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] HSP72複合体の単離による血中微量タンパク質の同定2018
- Author(s)
  塩田正之、田中昌子、鰐渕英機、徳永文稔
- Organizer
  第１３回臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] 自然免疫制御に関わる新規RING型E3(RNF126)の同定と機能解析2018
- Author(s)
  阿部貴則、及川大輔、寺脇正剛、後藤栄治、高橋宏隆、大竹史明、川原裕之、堀居拓郎、畑田出穂、佐伯泰、田中啓二、澤崎達也、徳永文稔
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] HSP72複合体の単離による血中微量タンパク質の同定2018
- Author(s)
  塩田正之、田中昌子、鰐渕英機、徳永文稔
- Organizer
  第１３回臨床ストレス応答学会大会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] OTUD1は自然免疫制御に関わる脱ユビキチン化酵素である2018
- Author(s)
  駒倉啓大、後藤栄治、及川大輔、阿部貴則、徳永文稔
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] オートファジーアダプターNDP52による新規NF-κB・細胞死制御機構2018
- Author(s)
  及川大輔、駒倉啓大、徳永文稔
- Organizer
  第９１回日本生化学会大会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] 新規LUBAC阻害剤の探索と機能評価2018
- Author(s)
  及川大輔、花田和希、勝矢健、菅原弘二、水上裕加里、鶴田大輔、坂本信二、徳永文稔
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] T細胞受容体を介したNF-κBシグナル制御の数理シミュレーション2018
- Author(s)
  後藤栄治、浜田大輔、及川大輔、鈴木貴、徳永文稔
- Organizer
  第９１回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] コムギ無細胞系を用いて作製した脱ユビキチン化酵素(DUB)プロテインアレイによるポリユビキチン鎖基質特異性とDUB阻害剤の選択性評価2018
- Author(s)
  高橋宏隆、山中聡士、桒田翔平、後藤栄治、今井賢一郎、富井健太郎、佐藤裕介、深井周也、徳永文稔、澤崎達也
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] Characterization of a novel LUBAC inhibitor, HOIPIN-12018
- Author(s)
  Oikawa D, Hanada K, Terawaki S, Sakamoto S, Tokunaga F
- Organizer
  Keystone Symposia-ubiquitin signaling
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Presentation] Characterization of a novel LUBAC inhibitor, HOIPIN-12018
- Author(s)
  Oikawa D, Hanada K, Terawaki S, Sakamoto S, Tokunaga F
- Organizer
  Keystone Symposia-ubiquitin signaling
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] 直鎖状ユビキチン鎖生成酵素(LUBAC)に対する新規阻害剤の開発と炎症病態抑制2018
- Author(s)
  及川大輔、花田和希、勝矢健、菅原弘二、水上裕加里、鶴田大輔、坂本信二、徳永文稔
- Organizer
  第１３回臨床ストレス応答学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] 直鎖状ユビキチン鎖生成酵素(LUBAC)に対する新規阻害剤の開発と炎症病態抑制2018
- Author(s)
  及川大輔、花田和希、勝矢健、菅原弘二、水上裕加里、鶴田大輔、坂本信二、徳永文稔
- Organizer
  第１３回臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] オートファジーアダプターNDP52による新規NF-κB・細胞死制御機構2018
- Author(s)
  及川大輔、駒倉啓大、徳永文稔
- Organizer
  第９１回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] 自然免疫制御に関わる新規脱ユビキチン化酵素（OTUD1）の同定と生理機能解析2018
- Author(s)
  駒倉啓大、後藤栄治、及川大輔、阿部貴則、徳永文稔
- Organizer
  第１３回臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] Characterization of a novel LUBAC inhibitor, HOIPIN-12018
- Author(s)
  Oikawa D, Hanada K, Terawaki S, Sakamoto S, Tokunaga F
- Organizer
  Keystone Symposia-ubiquitin signaling
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15210
[Presentation] 新規LUBAC阻害剤の探索と機能評価2018
- Author(s)
  及川大輔、花田和希、勝矢健、菅原弘二、水上裕加里、鶴田大輔、坂本信二、徳永文稔
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] コムギ無細胞系を用いて作製した脱ユビキチン化酵素(DUB)プロテインアレイによるポリユビキチン鎖基質特異性とDUB阻害剤の選択性評価2018
- Author(s)
  高橋宏隆、山中聡士、桒田翔平、後藤栄治、今井賢一郎、富井健太郎、佐藤裕介、深井周也、徳永文稔、澤崎達也
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] 新規LUBAC阻害剤、HOIPIN-1の作用機序と病態抑制効果2018
- Author(s)
  及川大輔、花田和希、菅原弘二、寺脇正剛、水上裕加里、鶴田大輔、坂本信二、徳永文稔
- Organizer
  第６５回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] 自然免疫制御に関わる新規RING型E3(RNF126)の同定と機能解析2018
- Author(s)
  阿部貴則、及川大輔、寺脇正剛、後藤栄治、高橋宏隆、大竹史明、川原裕之、堀居拓郎、畑田出穂、佐伯泰、田中啓二、澤崎達也、徳永文稔
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] T細胞受容体を介したNF-κBシグナル制御の数理シミュレーション2018
- Author(s)
  後藤栄治、浜田大輔、及川大輔、鈴木貴、徳永文稔
- Organizer
  第９１回日本生化学会大会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] Characterization of a novel LUBAC inhibitor, HOIPIN-12018
- Author(s)
  Oikawa D, Hanada K, Terawaki S, Sakamoto S, Tokunaga F.
- Organizer
  Keystone Symposium; Ubiquitin Signaling.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08259
[Presentation] TCRシグナルにおける直鎖状ユビキチン化の数理モデル解析2018
- Author(s)
  後藤栄治、浜田大輔、及川大輔、鈴木貴、徳永文稔
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] Characterization of a novel LUBAC inhibitor, HOIPIN-12018
- Author(s)
  Oikawa D, Hanada K, Terawaki S, Sakamoto S, Tokunaga F
- Organizer
  Keystone Symposia-ubiquitin signaling
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] OTUD1は自然免疫制御に関わる脱ユビキチン化酵素である2018
- Author(s)
  駒倉啓大、後藤栄治、及川大輔、阿部貴則、徳永文稔
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] 新規LUBAC阻害剤、HOIPIN-1の作用機序と病態抑制効果2018
- Author(s)
  及川大輔、花田和希、菅原弘二、寺脇正剛、水上裕加里、鶴田大輔、坂本信二、徳永文稔
- Organizer
  第６５回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-18H02619
[Presentation] 自然免疫制御に関わる新規脱ユビキチン化酵素（OTUD1）の同定と生理機能解析2018
- Author(s)
  駒倉啓大、後藤栄治、及川大輔、阿部貴則、徳永文稔
- Organizer
  第１３回臨床ストレス応答学会大会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] 直鎖状ユビキチン鎖生成酵素(LUBAC)に対する新規阻害剤の細胞・生化学機構と疾患治療への応用2017
- Author(s)
  及川大輔、葛谷早喜子、花田和希、寺脇正剛、鶴田大輔、坂本信二、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] マイトファジー受容体のユビキチン結合性はNF-κBと細胞死制御に関与する2017
- Author(s)
  葛谷早喜子、及川大輔、徳永文稔
- Organizer
  バイオインターフェース先端マテリアルの創生第7回シンポジウム
- Place of Presentation
  大阪市立大学（大阪府大阪市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-15K08259
[Presentation] 85種類のヒト脱ユビキチン化酵素(DUB)の完全超組換えタンパク質を用いたポリユビキチン鎖特異性決定とDUB阻害評価系の構築2017
- Author(s)
  桑田翔平、山中総士、岡田健吾、後藤栄治、徳永文稔、高橋宏隆、澤崎達也
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K15210
[Presentation] マイトファジー受容体のユビキチン結合性はNF-κBと細胞死制御に関与する2017
- Author(s)
  及川大輔、徳永文稔
- Organizer
  第64回日本生化学会　近畿支部会
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] 直鎖状ユビキチン鎖生成酵素(LUBAC)に対する新規阻害剤の細胞・生化学機構と疾患治療への応用2017
- Author(s)
  及川大輔、葛谷早喜子、花田和希、寺脇正剛、鶴田大輔、坂本信二、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] 直鎖状ユビキチン鎖生成酵素(LUBAC)に対する新規阻害剤によるNF-kB制御と疾患応用を目指した基礎解析2017
- Author(s)
  及川大輔、花田和希、寺脇正剛、葛谷早喜子、菅原弘二、鶴田大輔、坂本信二、徳永文稔
- Organizer
  第12回臨床ストレス応答学会
- Data Source
  KAKENHI-PROJECT-15K08259
[Presentation] 直鎖状ユビキチン鎖生成酵素(LUBAC)に対する新規阻害剤の細胞・生化学機構と疾患治療への応用2017
- Author(s)
  及川大輔、葛谷早喜子、花田和希、寺脇正剛、鶴田大輔、坂本信二、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K15210
[Presentation] マイトファジー受容体のユビキチン結合性はNF-κBと細胞死制御に関与する2017
- Author(s)
  及川大輔、徳永文稔
- Organizer
  第64回日本生化学会　近畿支部会
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] JurkatヒトT細胞株におけるLUBACの機能解析2017
- Author(s)
  後藤栄治、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K15210
[Presentation] NF-κB活性制御に関わる新規OTU型脱ユビキチン化酵素の同定2017
- Author(s)
  後藤栄治、阿部貴則、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K15210
[Presentation] NF-κB活性制御に関わる新規OTU型脱ユビキチン化酵素の同定2017
- Author(s)
  後藤栄治、阿部貴則、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] NDP52のユビキチン結合性はNF-κBと細胞死制御に関与する2017
- Author(s)
  葛谷早喜子、及川大輔、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] コムギ無細胞人プレテインアレイを基盤とした新規直鎖状ユビキチン結合タンパク質の探索と機能解析2017
- Author(s)
  長尾和哉、中島達朗、高橋宏隆、徳永文稔、澤崎達也
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K15210
[Presentation] NDP52のユビキチン結合性はNF-κBと細胞死制御に関与する2017
- Author(s)
  葛谷早喜子、及川大輔、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K15210
[Presentation] JurkatヒトT細胞株におけるLUBACの機能解析2017
- Author(s)
  後藤栄治、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Presentation] 直鎖状ユビキチン鎖生成酵素(LUBAC)に対する新規阻害剤の細胞・生化学機構と疾患治療への応用2017
- Author(s)
  及川大輔、葛谷早喜子、花田和希、寺脇正剛、鶴田大輔、坂本信二、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15K08259
[Presentation] 85種類のヒト脱ユビキチン化酵素(DUB)の完全超組換えタンパク質を用いたポリユビキチン鎖特異性決定とDUB阻害評価系の構築2017
- Author(s)
  桑田翔平、山中総士、岡田健吾、後藤栄治、徳永文稔、高橋宏隆、澤崎達也
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] マイトファジーアダプター(NDP52)のユビキチン結合性はNF-kBと細胞死制御に関与する2017
- Author(s)
  及川大輔、徳永文稔
- Organizer
  第64回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-15K08259
[Presentation] LUBAC活性を制御する新規RING型ユビキチンリガーゼの機能解析2017
- Author(s)
  阿部貴則、後藤栄治、及川大輔、高橋宏隆、堀居拓郎、寺脇正剛、畑田出穂、澤崎達也、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Presentation] コムギ無細胞人プレテインアレイを基盤とした新規直鎖状ユビキチン結合タンパク質の探索と機能解析2017
- Author(s)
  長尾和哉、中島達朗、高橋宏隆、徳永文稔、澤崎達也
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] NF-κB活性制御に関わる新規OTU型脱ユビキチン化酵素の同定2017
- Author(s)
  後藤栄治、阿部貴則、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] LUBAC活性を制御する新規RING型ユビキチンリガーゼの機能解析2017
- Author(s)
  阿部貴則、後藤栄治、及川大輔、高橋宏隆、堀居拓郎、寺脇正剛、畑田出穂、澤崎達也、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K15210
[Presentation] LUBAC活性を制御する新規RING型ユビキチンリガーゼの機能解析2017
- Author(s)
  阿部貴則、後藤栄治、及川大輔、高橋宏隆、堀居拓郎、寺脇正剛、畑田出穂、澤崎達也、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] NDP52のユビキチン結合性はNF-κBと細胞死制御に関与する2017
- Author(s)
  葛谷早喜子、及川大輔、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Presentation] NF-κB活性制御に関わる新規OTU型脱ユビキチン化酵素の同定2017
- Author(s)
  後藤栄治、阿部貴則、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Presentation] コムギ無細胞人プレテインアレイを基盤とした新規直鎖状ユビキチン結合タンパク質の探索と機能解析2017
- Author(s)
  長尾和哉、中島達朗、高橋宏隆、徳永文稔、澤崎達也
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] 85種類のヒト脱ユビキチン化酵素(DUB)の完全超組換えタンパク質を用いたポリユビキチン鎖特異性決定とDUB阻害評価系の構築2017
- Author(s)
  桑田翔平、山中総士、岡田健吾、後藤栄治、徳永文稔、高橋宏隆、澤崎達也
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Presentation] JurkatヒトT細胞株におけるLUBACの機能解析2017
- Author(s)
  後藤栄治、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] NDP52のユビキチン結合性はNF-κBと細胞死制御に関与する2017
- Author(s)
  葛谷早喜子、及川大輔、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] LUBAC活性を制御する新規RING型ユビキチンリガーゼの機能解析2017
- Author(s)
  阿部貴則、後藤栄治、及川大輔、高橋宏隆、堀居拓郎、寺脇正剛、畑田出穂、澤崎達也、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] マイトファジー受容体のユビキチン結合性はNF-κBと細胞死制御に関与する2017
- Author(s)
  及川大輔、徳永文稔
- Organizer
  第64回日本生化学会　近畿支部会
- Data Source
  KAKENHI-PROJECT-16K15210
[Presentation] 85種類のヒト脱ユビキチン化酵素(DUB)の完全超組換えタンパク質を用いたポリユビキチン鎖特異性決2017
- Author(s)
  桑田翔平、山中総士、岡田健吾、後藤栄治、徳永文稔、高橋宏隆、澤崎達也
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] 直鎖状ユビキチン鎖生成酵素(LUBAC)に対する新規阻害剤の細胞・生化学機構と疾患治療への応用2017
- Author(s)
  及川大輔、葛谷早喜子、花田和希、寺脇正剛、鶴田大輔、坂本信二、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Presentation] マイトファジー受容体のユビキチン結合性はNF-κBと細胞死制御に関与する2017
- Author(s)
  及川大輔、徳永文稔
- Organizer
  第64回日本生化学会　近畿支部会
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Presentation] NDP52のユビキチン結合性はNF-kBと細胞死制御に関与する2017
- Author(s)
  葛谷早喜子、及川大輔、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15K08259
[Presentation] コムギ無細胞人プレテインアレイを基盤とした新規直鎖状ユビキチン結合タンパク質の探索と機能解析2017
- Author(s)
  長尾和哉、中島達朗、高橋宏隆、徳永文稔、澤崎達也
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Presentation] JurkatヒトT細胞株におけるLUBACの機能解析2017
- Author(s)
  後藤栄治、徳永文稔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] 直鎖状ユビキチン鎖による炎症・免疫シグナル制御とその破綻による疾患2016
- Author(s)
  徳永文稔
- Organizer
  第67回日本電気泳動学会総会
- Place of Presentation
  釧路市観光国際交流センター（北海道釧路市）
- Year and Date
  2016-08-27
- Invited
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] Optineurinの直鎖状ユビキチン鎖結合性と筋萎縮性側索硬化症2016
- Author(s)
  徳永文稔
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Presentation] コムギ無細胞タンパク質アレイ解析によって見出された、NEMO結合性新規DUBのNF-κB制御機構の解析2016
- Author(s)
  高橋宏隆, 桑田翔平, 後藤栄治, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] 直鎖状ユビキチン鎖による炎症・免疫シグナル制御とその破綻による疾患2016
- Author(s)
  徳永文稔
- Organizer
  第67回日本電気泳動学会総会
- Place of Presentation
  釧路市観光国際交流センター（北海道釧路市）
- Year and Date
  2016-08-27
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] コムギ無細胞系を基盤としたヒトの脱ユビキチン化酵素(DUB)プロテインアレイを用いたポリユビキチン基質特異性解析2016
- Author(s)
  桑田翔平,岡田健吾, 高橋宏隆, 後藤栄治, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] Optineurinの直鎖状ユビキチン鎖結合性と筋萎縮性側索硬化症2016
- Author(s)
  徳永文稔
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-16K15210
[Presentation] コムギ無細胞タンパク質アレイ解析によって見出された、NEMO結合性新規DUBのNF-κB制御機構の解析2016
- Author(s)
  高橋宏隆, 桑田翔平, 後藤栄治, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-16K15210
[Presentation] コムギ無細胞ヒト20,000種プロテインアレイを基盤とした直鎖状ポリユビキチン鎖結合タンパク質の探索2016
- Author(s)
  中島達朗, 高橋宏隆, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシィフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] コムギ無細胞ヒト20,000種プロテインアレイを基盤とした直鎖状ポリユビキチン鎖結合タンパク質の探索2016
- Author(s)
  中島達朗, 高橋宏隆, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Presentation] コムギ無細胞ヒト20,000種プロテインアレイを基盤とした直鎖状ポリユビキチン鎖結合タンパク質の探索2016
- Author(s)
  中島達朗, 高橋宏隆, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16K15210
[Presentation] 筋萎縮性側索硬化症(ALS)における直鎖状ユビキチン鎖の寄与2016
- Author(s)
  徳永文稔
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-16K15210
[Presentation] Optineurinの直鎖状ユビキチン鎖結合性と筋萎縮性側索硬化症2016
- Author(s)
  徳永文稔
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] コムギ無細胞タンパク質アレイ解析によって見出された、NEMO結合性新規DUBのNF-κB制御機構の解析2016
- Author(s)
  高橋宏隆, 桑田翔平, 後藤栄治, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシィフコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] コムギ無細胞系を基盤としたヒトの脱ユビキチン化酵素(DUB)プロテインアレイを用いたポリユビキチン基質特異性解析2016
- Author(s)
  桑田翔平,岡田健吾, 高橋宏隆, 後藤栄治, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシィフコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] Optineurinの直鎖状ユビキチン鎖結合性と筋萎縮性側索硬化症2016
- Author(s)
  徳永文稔
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] コムギ無細胞タンパク質アレイ解析によって見出された、NEMO結合性新規DUBのNF-κB制御機構の解析2016
- Author(s)
  高橋宏隆, 桑田翔平, 後藤栄治, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] 筋萎縮性側索硬化症(ALS)における直鎖状ユビキチン鎖の寄与2016
- Author(s)
  徳永文稔
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-26
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] Optineurinの直鎖状ユビキチン鎖結合性と筋萎縮性側索硬化症2016
- Author(s)
  徳永文稔
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシィフコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] コムギ無細胞系を基盤としたヒトの脱ユビキチン化酵素(DUB)プロテインアレイを用いたポリユビキチン基質特異性解析2016
- Author(s)
  桑田翔平,岡田健吾, 高橋宏隆, 後藤栄治, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Presentation] 筋萎縮性側索硬化症(ALS)における直鎖状ユビキチン鎖の寄与2016
- Author(s)
  徳永文稔
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] 直鎖状ユビキチン鎖による炎症・免疫シグナル制御とその破綻による疾患2016
- Author(s)
  徳永文稔
- Organizer
  第67回日本電気泳動学会総会
- Place of Presentation
  釧路市観光国際交流センター
- Year and Date
  2016-08-26
- Invited
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] コムギ無細胞ヒト20,000種プロテインアレイを基盤とした直鎖状ポリユビキチン鎖結合タンパク質の探索2016
- Author(s)
  中島達朗, 高橋宏隆, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] 直鎖状ユビキチン鎖による炎症・免疫シグナル制御とその破綻による疾患2016
- Author(s)
  徳永文稔
- Organizer
  第67回日本電気泳動学会総会
- Place of Presentation
  釧路市観光国際交流センター（北海道釧路市）
- Year and Date
  2016-08-27
- Invited
- Data Source
  KAKENHI-PROJECT-16K15210
[Presentation] コムギ無細胞系を基盤としたヒトの脱ユビキチン化酵素(DUB)プロテインアレイを用いたポリユビキチン基質特異性解析2016
- Author(s)
  桑田翔平,岡田健吾, 高橋宏隆, 後藤栄治, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16K15210
[Presentation] 直鎖状ユビキチン鎖による炎症・免疫シグナル制御とその破綻による疾患2016
- Author(s)
  徳永文稔
- Organizer
  第67回日本電気泳動学会総会
- Place of Presentation
  釧路市観光国際交流センター（北海道釧路市）
- Year and Date
  2016-08-27
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Presentation] コムギ無細胞系を基盤としたヒトの脱ユビキチン化酵素(DUB)プロテインアレイを用いたポリユビキチン基質特異性解析2016
- Author(s)
  桑田翔平,岡田健吾, 高橋宏隆, 後藤栄治, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] 筋萎縮性側索硬化症(ALS)における直鎖状ユビキチン鎖の寄与2016
- Author(s)
  徳永文稔
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] コムギ無細胞タンパク質アレイ解析によって見出された、NEMO結合性新規DUBのNF-κB制御機構の解析2016
- Author(s)
  高橋宏隆, 桑田翔平, 後藤栄治, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Presentation] Optineurin遺伝子変異に伴うALS発症における直鎖状ポリユビキチン鎖の寄与2016
- Author(s)
  及川大輔、中澤世識、石井亮平、綾木孝、石谷隆一郎、伊東秀文、濡木理、徳永文稔
- Organizer
  第494回大阪市医学会
- Place of Presentation
  大阪市立大学（大阪府大阪市）
- Year and Date
  2016-10-20
- Data Source
  KAKENHI-PROJECT-15K08259
[Presentation] 筋萎縮性側索硬化症(ALS)における直鎖状ユビキチン鎖の寄与2016
- Author(s)
  徳永文稔
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-26
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01192
[Presentation] コムギ無細胞ヒト20,000種プロテインアレイを基盤とした直鎖状ポリユビキチン鎖結合タンパク質の探索,2016
- Author(s)
  中島達朗, 高橋宏隆, 徳永文稔, 澤崎達也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PLANNED-16H06575
[Presentation] Optineurinによる直鎖状ポリユビキチン鎖結合を介したNF-κBとアポトーシス制御2015
- Author(s)
  及川大輔、石井亮平、中澤世識、石谷隆一郎、濡木理、徳永文稔
- Organizer
  第67回日本細胞生物学会
- Place of Presentation
  東京
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] 非アルコール性脂肪性肝炎におけるLUBAC形成傷害の解析2015
- Author(s)
  松永泰花、中津祐介、福嶋俊明、大久保博史、岩下未咲、迫田秀之、藤城緑、山本屋武、櫛山暁史、高橋伸一郎、土谷佳弘、鎌田英明、徳永文稔、岩井一宏、浅野知一郎
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] T細胞受容体(TCR)を介したNF-κB活性化機構におけるLUBACの関与2015
- Author(s)
  後藤栄治、徳永文稔
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] コムギ無細胞系を基盤とした脱ユビキチン化酵素CYLDおよびOTULINの阻害剤開発2015
- Author(s)
  山中聡士、高橋宏隆、徳永文稔、澤崎達也
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] Linear ubiquitination-mediated NF-κB regulation.2015
- Author(s)
  Fuminori Tokunaga
- Organizer
  2nd International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling.
- Place of Presentation
  東京大学医科学研究所（東京）
- Year and Date
  2015-01-23
- Invited
- Data Source
  KAKENHI-PROJECT-25670137
[Presentation] Optineurin遺伝子変異に伴うALS発症における直鎖状ポリユビキチン鎖の寄与2015
- Author(s)
  及川大輔、中澤世識、石井亮平、綾木孝、石谷隆一郎、伊東秀文、濡木理、徳永文稔
- Organizer
  第10回臨床ストレス応答学会
- Place of Presentation
  東京
- Year and Date
  2015-11-06
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] Linear ubiquitin-binding by optineurin regulates NF-κB activation and apoptosis.2015
- Author(s)
  Tokunaga F
- Organizer
  15th International TNF Conference
- Place of Presentation
  Ghent, Belgium
- Year and Date
  2015-05-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] 直鎖状ユビキチン鎖産生酵素(LUBAC)の新規調節因子の同定と免疫・炎症制御2015
- Author(s)
  阿部貴則、及川大輔、高橋宏隆、澤崎達也、徳永文稔
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] 直鎖状ユビキチン鎖を介したNF-κB活性化を制御する脱ユビキチン化酵素の探索2015
- Author(s)
  片山雄貴、後藤栄治、徳永文稔
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] 表皮基底層にⅦ型コラーゲン沈着が見られた優性栄養障害型表皮水泡症（前脛骨型）の1例2015
- Author(s)
  服部麻衣、清水晶、加藤円香、天野博雄、山本明美、中野創、澤村大輔、及川大輔、亀井希代子、徳永文、石川治
- Organizer
  第62回北関東医学会総会
- Place of Presentation
  群馬大学
- Year and Date
  2015-10-01
- Data Source
  KAKENHI-PROJECT-15K08259
[Presentation] コムギ無細胞系を基盤としたインタラクトーム解析に向けた脱ユビキチン化酵素プロテインアレイの構築2015
- Author(s)
  土居耕介、高橋宏隆、後藤栄治、徳永文稔、澤崎達也
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] 直鎖状ユビキチン鎖を介したNF-κB活性化を制御する脱ユビキチン化酵素の探索2015
- Author(s)
  片山雄貴、後藤栄治、徳永文稔
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] Optineurin遺伝子変異に伴うALS発症における直鎖状ポリユビキチン鎖の寄与2015
- Author(s)
  及川大輔、中澤世識、石井亮平、綾木孝、石谷隆一郎、伊東秀文、濡木理、徳永文稔
- Organizer
  第10回臨床ストレス応答学会
- Place of Presentation
  東京
- Year and Date
  2015-11-06
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] T細胞受容体(TCR)を介したNF-κB活性化機構におけるLUBACの関与2015
- Author(s)
  後藤栄治、徳永文稔
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] 非アルコール性脂肪性肝炎におけるLUBAC形成傷害の解析2015
- Author(s)
  松永泰花、中津祐介、福嶋俊明、大久保博史、岩下未咲、迫田秀之、藤城緑、山本屋武、櫛山暁史、高橋伸一郎、土谷佳弘、鎌田英明、徳永文稔、岩井一宏、浅野知一郎
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] 直鎖状ユビキチン鎖産生酵素(LUBAC)の新規調節因子の同定と免疫・炎症制御2015
- Author(s)
  阿部貴則、及川大輔、高橋宏隆、澤崎達也、徳永文稔
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] Generalized verrucosis caused by a GATA2 deficiency.2015
- Author(s)
  Hattori M, Shimizu A, Amano H, Ishikawa O, Mitsui T, Kaira K, Oikawa D, Tokunaga F, Nakano H, and Sawamura D.
- Organizer
  第41回日本研究皮膚科学会
- Place of Presentation
  岡山
- Year and Date
  2015-12-11
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] コムギ無細胞系を基盤とした脱ユビキチン化酵素CYLDおよびOTULINの阻害剤開発2015
- Author(s)
  山中聡士、高橋宏隆、徳永文稔、澤崎達也
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] 脱ユビキチン化酵素CYLDを分解し、がん化を促進するE3リガーゼの同定・解析2015
- Author(s)
  上松篤史、高橋宏隆、竹田浩之、徳永文稔、山田六平、宮崎洋平、澤崎達也
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] 脱ユビキチン化酵素CYLDを分解し、がん化を促進するE3リガーゼの同定・解析2015
- Author(s)
  上松篤史、高橋宏隆、竹田浩之、徳永文稔、山田六平、宮崎洋平、澤崎達也
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] GATA2遺伝子変異によるgeneralized verrucosis発症メカニズムの検討2015
- Author(s)
  服部麻衣、清水晶、石川治、及川大輔、徳永文稔、解良恭一、三井健揮、中野創、澤村大輔
- Organizer
  第66回日本皮膚科学会中部支部学術大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-15K08259
[Presentation] Linear ubiquitination-mediated NF-κB regulation.2015
- Author(s)
  Fuminori Tokunaga
- Organizer
  2nd International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling.
- Place of Presentation
  東京大学医科学研究所（東京）
- Year and Date
  2015-01-23
- Invited
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] Optineurinによる直鎖状ポリユビキチン鎖結合を介したNF-κBとアポトーシス制御2015
- Author(s)
  及川大輔、石井亮平、中澤世識、石谷隆一郎、濡木理、徳永文稔
- Organizer
  第67回日本細胞生物学会
- Place of Presentation
  東京
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] コムギ無細胞ヒト20,000種プロテインアレイを基盤とした直鎖状ユビキチン鎖結合タンパク質の探索2015
- Author(s)
  中島達朗、高橋宏隆、竹田浩之、徳永文稔、澤崎達也
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] コムギ無細胞系を基盤としたインタラクトーム解析に向けた脱ユビキチン化酵素プロテインアレイの構築2015
- Author(s)
  土居耕介、高橋宏隆、後藤栄治、徳永文稔、澤崎達也
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] Generalized verrucosis caused by a GATA2 deficiency2015
- Author(s)
  Mai Hattori, Akira Shimizu, Hiroo Amano, Osamu Ishikawa, Takeki Mitsui, Kyoichi Kaira, Daisuke Oikawa, Fuminori Tokunaga, Hajime Nakano, Daisuke Sawamura
- Organizer
  日本研究皮膚科学会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2015-12-11
- Data Source
  KAKENHI-PROJECT-15K08259
[Presentation] Optineurinによる直鎖状ポリユビキチン鎖結合を介したNF-κBとアポトーシス制御2015
- Author(s)
  及川大輔、石井亮平、中澤世識、石谷隆一郎、濡木理、徳永文稔
- Organizer
  第67回日本細胞生物学会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-15K08259
[Presentation] Linear ubiquitin-binding by optineurin regulates NF-κB activation and apoptosis.2015
- Author(s)
  Tokunaga F
- Organizer
  15th International TNF Conference
- Place of Presentation
  Ghent, Belgium
- Year and Date
  2015-05-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] 直鎖状ユビキチン鎖産生酵素(LUBAC)の新規調節因子の同定と免疫・炎症制御2015
- Author(s)
  阿部貴則、及川大輔、高橋宏隆、澤崎達也、徳永文稔
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15K08259
[Presentation] Optineurin遺伝子変異に伴うALS発症における直鎖状ポリユビキチン鎖の寄与2015
- Author(s)
  及川大輔、中澤世識、石井亮平、綾木孝、石谷隆一郎、伊東秀文、濡木理、徳永文稔
- Organizer
  第10回臨床ストレス応答学会
- Place of Presentation
  東京農工大学
- Year and Date
  2015-11-06
- Data Source
  KAKENHI-PROJECT-15K08259
[Presentation] Generalized verrucosis caused by a GATA2 deficiency.2015
- Author(s)
  Hattori M, Shimizu A, Amano H, Ishikawa O, Mitsui T, Kaira K, Oikawa D, Tokunaga F, Nakano H, and Sawamura D.
- Organizer
  第41回日本研究皮膚科学会
- Place of Presentation
  岡山
- Year and Date
  2015-12-11
- Data Source
  KAKENHI-PROJECT-15H04694
[Presentation] コムギ無細胞ヒト20,000種プロテインアレイを基盤とした直鎖状ユビキチン鎖結合タンパク質の探索2015
- Author(s)
  中島達朗、高橋宏隆、竹田浩之、徳永文稔、澤崎達也
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01172
[Presentation] RISPR/Cas9法を用いたLUBAC欠損細胞の作製とNF-κB活性制御への影響2014
- Author(s)
  後藤栄治、徳永文稔
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-25670137
[Presentation] Optineurinの直鎖状ユビキチン結合を介したNF-κB制御と疾患との関連2014
- Author(s)
  及川大輔、石井亮平、中澤世識、石谷隆一郎、濡木理、徳永文稔
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-25670137
[Presentation] 直鎖状ユビキチン鎖生成を介したNF- κ Bシグナル制御と疾患2014
- Author(s)
  徳永文稔
- Organizer
  東京工業大学バイオサイエンスシンポジウム
- Place of Presentation
  横浜
- Year and Date
  2014-02-18
- Invited
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] 新規LUBACシグナル複合体構成因子の探索と細胞機能解析2014
- Author(s)
  及川大輔、中澤世識、徳永文稔
- Organizer
  第66回日本細胞生物学会
- Place of Presentation
  奈良県新公会堂（奈良市）
- Year and Date
  2014-06-13
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] Optineurinの直鎖状ユビキチン結合を介したNF-κB制御と疾患との関連2014
- Author(s)
  及川大輔、石井亮平、中澤世識、石谷隆一郎、濡木理、徳永文稔
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] 直鎖状ユビキチン鎖生成を介したNF-κBシグナル制御の分子基盤2014
- Author(s)
  徳永文稔
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館（京都市）
- Year and Date
  2014-10-16
- Invited
- Data Source
  KAKENHI-PROJECT-25670137
[Presentation] 新規LUBACシグナル複合体構成因子の探索と細胞機能解析2014
- Author(s)
  及川大輔、中澤世識、徳永文稔
- Organizer
  第66回日本細胞生物学会
- Place of Presentation
  奈良県新公会堂（奈良市）
- Year and Date
  2014-06-30
- Data Source
  KAKENHI-PROJECT-25670137
[Presentation] 直鎖状ポリユビキチン修飾を介したNF- κ B制御のB細胞リンパ腫発症における役割2014
- Author(s)
  徳永文稔
- Organizer
  日本薬学会第4 134年会シンポジウム : 翻訳後修飾に着目したシグナル伝達研究と創薬の最前線
- Place of Presentation
  熊本
- Year and Date
  2014-03-30
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] OptineurinのNF-κBシグナル制御の細胞機構と疾患2014
- Author(s)
  及川大輔、石井亮平、中澤世識、石谷隆一郎、濡木理、徳永文稔
- Organizer
  第９回臨床外レス応答学会
- Place of Presentation
  岡山大学（岡山市）
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] CRISPR/Cas9法を用いたLUBAC欠損細胞の作製とNF-κB活性制御への影響2014
- Author(s)
  後藤栄治、徳永文稔
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] OptineurinのNF-κBシグナル制御の細胞機構と疾患2014
- Author(s)
  及川大輔、石井亮平、中澤世識、石谷隆一郎、濡木理、徳永文稔
- Organizer
  第９回臨床外レス応答学会
- Place of Presentation
  岡山大学（岡山市）
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PROJECT-25670137
[Presentation] 癌抑制遺伝子STK11による細胞死制御機構2014
- Author(s)
  野口拓也、熊澤琢也、徳永文稔
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館（京都市）
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] 直鎖状ユビキチン鎖生成を介したNF-κBシグナル制御の分子基盤2014
- Author(s)
  徳永文稔
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館（京都市）
- Year and Date
  2014-10-16
- Invited
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] 癌抑制遺伝子STK11による細胞死制御機構2014
- Author(s)
  野口拓也、熊澤琢也、徳永文稔
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館（京都市）
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-25670137
[Presentation] Linear ubiquitin binding via A20 zinc finger 7 is involved in the canonical NF-κB regulation2013
- Author(s)
  Fuminori Tokunaga, Hiroshi Nishimasu, Ryuichiro Ishitani, and Osamu Nureki
- Organizer
  Frontiers in the immunology and inflammation : From molecules to disease
- Place of Presentation
  Tokyo
- Year and Date
  2013-02-12
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] Linear ubiquitin binding via A20 zinc finger 7 is involved in the canonical NF-κB regulation.2013
- Author(s)
  Tokunaga, F.
- Organizer
  Frontiers in the immunology and inflammation: From molecules to disease.
- Place of Presentation
  Tokyo、学術総合センター　一橋講堂
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] 直鎖状ユビキチン化を介する NF-κB制御に関わる脱ユビキチン化酵素と疾患2013
- Author(s)
  徳永文稔,西増弘志,石谷隆一郎,濡木理
- Organizer
  病態プロテアーゼ学会
- Place of Presentation
  大阪
- Year and Date
  2013-08-16
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] Linear ubiquitination-mediated NF-κB regulation mechanism and its related disorders2013
- Author(s)
  Fuminori Tokunaga
- Organizer
  プロテイン・アイランド・松山 (PIM) 国際シンポジウム2013
- Place of Presentation
  松山
- Year and Date
  2013-09-18
- Invited
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] Linear ubiquitin binding via A20 zinc finger 7 is involved in the canonical NF-κB regulation.2013
- Author(s)
  Tokunaga, F.
- Organizer
  Frontiers in the immunology and inflammation: From molecules to disease.
- Place of Presentation
  Tokyo、学術総合センター　一橋講堂
- Year and Date
  2013-02-12
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] Activation and regulation mechanisms of the linear ubiquitination-mediated NF-κB pathway2013
- Author(s)
  Fuminori Tokunaga
- Organizer
  1st International Symposium on Protein Modification in Pathogenic Dysregulation of Signaling
- Place of Presentation
  Tokyo
- Year and Date
  2013-02-01
- Data Source
  KAKENHI-PROJECT-23657075
[Presentation] Activation and regulation mechanisms of the linear ubiquitination-mediated NF-κB pathway.2013
- Author(s)
  Tokunaga, F.
- Organizer
  1st International Symposium on Protein Modification in Pathogenic Dysregulation of Signaling.
- Place of Presentation
  Tokyo、東大医科研
- Invited
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] ユビキチン修飾による細胞機能制御と疾患2013
- Author(s)
  徳永文稔
- Organizer
  第60回北関東医学会総会特別講演
- Place of Presentation
  前橋
- Year and Date
  2013-09-26
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] 直鎖状ユビキチン生成を介した NF-κB制御と B 細胞リンパ腫との連関2013
- Author(s)
  徳永文稔
- Organizer
  がん研究分野の特性を踏まえた支援活動公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2013-01-30
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] 直鎖状ポリユビキチン化を介したNF-κB制御と疾患2013
- Author(s)
  徳永文稔
- Organizer
  第86回日本生化学会シンポジウム次世代シグナル伝達研究への展開
- Place of Presentation
  横浜
- Year and Date
  2013-09-12
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] Activation and regulation mechanisms of the linear ubiquitination-mediated NF-κB pathway.2013
- Author(s)
  Tokunaga, F.
- Organizer
  1st International Symposium on Protein Modification in Pathogenic Dysregulation of Signaling.
- Place of Presentation
  Tokyo、東大医科研
- Year and Date
  2013-02-01
- Invited
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] Activation and regulation mechanisms of the linear ubiquitination-mediated NF-κB pathway.2013
- Author(s)
  Tokunaga, F.
- Organizer
  1st International Symposium on Protein Modification in Pathogenic Dysregulation of Signaling.
- Place of Presentation
  Tokyo、東大医科研
- Invited
- Data Source
  KAKENHI-PROJECT-23657075
[Presentation] Linear ubiquitin binding via A20 zinc finger 7 is involved in the canonical NF-κB regulation.2013
- Author(s)
  Tokunaga, F.
- Organizer
  Frontiers in the immunology and inflammation: From molecules to disease.
- Place of Presentation
  Tokyo、学術総合センター　一橋講堂
- Data Source
  KAKENHI-PROJECT-23657075
[Presentation] Linear ubiquitin binding via A20 zinc finger 7 is involved in the canonical NF-B regulation2013
- Author(s)
  Fuminori Tokunaga, Hiroshi Nishimasu, Ryuichiro Ishitani, and Osamu Nureki
- Organizer
  Frontiers in the immunology and inflammation: From molecules to disease.
- Place of Presentation
  Tokyo
- Year and Date
  2013-02-12
- Data Source
  KAKENHI-PROJECT-23657075
[Presentation] 直鎖状ユビキチン生成を介したNF-B制御とB細胞リンパ腫との連関2013
- Author(s)
  徳永文稔
- Organizer
  がん研究分野の特性を踏まえた支援活動公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2013-01-30
- Data Source
  KAKENHI-PROJECT-23657075
[Presentation] Down-regulation mechanism for LUBAC-induced NF-κB pathway2013
- Author(s)
  Fuminori Tokunaga
- Organizer
  The 35th Naito Conference : The ubiquitin-proteasome system: From basic mechanisms to pathophysiological roles
- Place of Presentation
  Sapporo
- Year and Date
  2013-07-11
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] Activation and regulation mechanisms of the linear ubiquitination-mediated NF-κB pathway2013
- Author(s)
  Fuminori Tokunaga
- Organizer
  1st International Symposium on Protein Modification in Pathogenic Dysregulation of Signaling
- Place of Presentation
  Tokyo
- Year and Date
  2013-02-01
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] A20の直鎖状ポリユビキチン鎖特異的結合を介したNF-κB制御.2012
- Author(s)
  徳永文稔
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡、福岡国際会議場
- Year and Date
  2012-12-14
- Invited
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] 直鎖状ポリユビキチン鎖:NF-κB制御に関わる新たな修飾機構と疾患2012
- Author(s)
  徳永文稔
- Organizer
  第9回Osteoimmunology Forum
- Place of Presentation
  東京
- Year and Date
  2012-02-04
- Data Source
  KAKENHI-PROJECT-23657075
[Presentation] A20 の直鎖状ポリユビキチン鎖特異的結合を介したNF-κB制御2012
- Author(s)
  徳永文稔,西増弘志,石谷隆一郎,後藤栄治,野口拓也,岩井一宏,濡木理
- Organizer
  第85回日本生化学会シンポジウム : ベールを脱いだユビキチン系の新機能
- Place of Presentation
  福岡
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] 直鎖状ユビキチン形成とNF-Bシグナル伝達2012
- Author(s)
  徳永文稔
- Organizer
  応用数理学会数理医学研究部会オーガナイズドセッション
- Place of Presentation
  稚内
- Year and Date
  2012-08-30
- Data Source
  KAKENHI-PROJECT-23657075
[Presentation] A20の直鎖状ポリユビキチン鎖特異的結合を介したNF-B制御2012
- Author(s)
  徳永文稔、西増弘志、石谷隆一郎、後藤栄治、野口拓也、岩井一宏、濡木理
- Organizer
  第85回日本生化学会シンポジウム:ベールを脱いだユビキチン系の新機能
- Place of Presentation
  福岡
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-23657075
[Presentation] 直鎖状ユビキチン形成とNF-κBシグナル伝達.2012
- Author(s)
  徳永文稔
- Organizer
  応用数理学会
- Place of Presentation
  稚内、全日空ホテル
- Invited
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] Specific recognition of linear ubiquitin by A20 zinc finger 7 is involved in NF-κB regulation2012
- Author(s)
  Fuminori Tokunaga
- Organizer
  Keystone Symposium
- Place of Presentation
  Whistler, Canada
- Year and Date
  2012-03-21
- Data Source
  KAKENHI-PROJECT-23657075
[Presentation] A20の直鎖状ポリユビキチン鎖特異的結合を介したNF-κB制御.2012
- Author(s)
  徳永文稔
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡、福岡国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-23657075
[Presentation] A20の直鎖状ポリユビキチン鎖特異的結合を介したNF-κB制御.2012
- Author(s)
  徳永文稔
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡、福岡国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] 直鎖状ポリユビキチン鎖 : NF-κB制御に関わる新たな修飾機構と疾患2012
- Author(s)
  徳永文稔
- Organizer
  第9回Osteoimmunology Forum
- Place of Presentation
  東京
- Year and Date
  2012-02-04
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] 直鎖状ユビキチン形成とNF-κBシグナル伝達.2012
- Author(s)
  徳永文稔
- Organizer
  応用数理学会
- Place of Presentation
  稚内、全日空ホテル
- Year and Date
  2012-08-29
- Invited
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] 直鎖状ユビキチン形成とNF-κBシグナル伝達.2012
- Author(s)
  徳永文稔
- Organizer
  応用数理学会
- Place of Presentation
  稚内、全日空ホテル
- Invited
- Data Source
  KAKENHI-PROJECT-23657075
[Presentation] Specific recognition of linear ubiquitin by A20 zinc finger 7 is involved in NF-κB regulation2012
- Author(s)
  Fuminori Tokunaga
- Organizer
  Keystone Symposium
- Place of Presentation
  Whistler, Canada
- Year and Date
  2012-03-21
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] 直鎖状ユビキチン形成と NF-κBシグナル伝達2012
- Author(s)
  徳永文稔
- Organizer
  応用数理学会数理医学研究部会オーガナイズドセッション
- Place of Presentation
  稚内
- Year and Date
  2012-08-30
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] Specific recognition of linear ubiquitin by A20 zinc finger 7 is involved in NF-κB regulation2012
- Author(s)
  Tokunaga, F.
- Organizer
  Keystone Symposium
- Place of Presentation
  Whistler, Canada
- Year and Date
  2012-03-21
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] 新規直鎖状ポリユビキチン鎖形成を介したNF-κBシグナル制御(シンポジウム)2011
- Author(s)
  徳永文稔
- Organizer
  新学術領域研究「修飾シグナル病」第1回公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] LUBACによる直鎖状ポリユビキチン鎖形成を介したNF-κB制御と疾患2011
- Author(s)
  徳永文稔
- Organizer
  第84回　日本生化学会大会シンポジウム(招待講演)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23657075
[Presentation] LUBACによる直鎖状ポリユビキチン鎖形成を介したNF-κB制御と疾患2011
- Author(s)
  徳永文稔
- Organizer
  第84回日本生化学会大会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] LUBACによる直鎖状ポリユビキチン鎖形成を介したNF-κB制御と疾患2011
- Author(s)
  徳永文稔、中原匡咲、岩井一宏
- Organizer
  第84回日本生化学会シンポジウム:拡大するユビキチンバイオロジー
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-23657075
[Presentation] LUBAC による直鎖状ポリユビキチン鎖形成を介したNF-κB制御と疾患2011
- Author(s)
  徳永文稔,中原匡咲,岩井一宏
- Organizer
  第84回日本生化学会シンポジウム : 拡大するユビキチンバイオロジー
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] LUBACによる直鎖状ポリユビキチン鎖形成を介したNF-kB制御と疾患2011
- Author(s)
  徳永文稔
- Organizer
  第84回日本生化学会大会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] Linear polyubiquitination : A new regulator of NF-κB activation(Invited Lecture).2010
- Author(s)
  徳永文稔
- Organizer
  Pacifichem
- Place of Presentation
  Honolulu, U.S.A
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] 直鎖状ポリユビキチン化によるNF-κB活性化制御と疾患2010
- Author(s)
  徳永文稔
- Organizer
  BMB2010(ワークショップ)
- Place of Presentation
  神戸ポートピアホテル(招待講演)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] 直鎖状ポリユビキチン化によるNF-κB活性化制御と疾患2010
- Author(s)
  徳永文稔
- Organizer
  BMB2010(ワークショップ)
- Place of Presentation
  神戸ポートピアホテル
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21657028
[Presentation] 直鎖状ポリユビキチン化によるNF-κB活性化制御と疾患2010
- Author(s)
  徳永文稔
- Organizer
  BMB2010(ワークショップ)
- Place of Presentation
  神戸ポートピアホテル(招待講演)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] 直鎖状ポリユビキチン鎖生成ユビキチンリガーゼ(LUBAC)の新規サブユニットの同定2010
- Author(s)
  徳永文稔、岩井一宏
- Organizer
  第2回シグナルネットワーク研究会
- Place of Presentation
  大阪
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] Linear polyubiquitination : A newly identified regulator of NF-κB signaling.2010
- Author(s)
  Iwai, K., Sakata, S.-I., Nakagawa, T., Tokunaga, F.
- Organizer
  Keystone Symposium "NF-κB in Inflammation and Disease"
- Place of Presentation
  Santa Fe, New Mexico, USA.
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] 新規直鎖状ポリユビキチン化によるNF-κB活性化制御と疾患(ワークショップ)2010
- Author(s)
  徳永文稔、岩井一宏
- Organizer
  VMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] Involvement of linear polyubiquitination of NEMO in NF-κB activation2009
- Author(s)
  Tokunaga, F., Sakata, S.-I., Nakagawa, T., Iwai, K.
- Organizer
  Cold Spring Harbor Laboratory meeting "The Ubiquitin Family"
- Place of Presentation
  Cold Spring Harbor, NY, USA.
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] NEM2分子以上の直鎖状ポリユビキチン化はNF-κB活性化を導く2009
- Author(s)
  徳永文稔、亀井希代子、岩井一宏
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] 直鎖状ポリユビキチン化 : NF-κB活性化を導く新たなポリユビキチン鎖2009
- Author(s)
  徳永文稔
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21657028
[Presentation] NEMOの2分子以上の直鎖状ポリュビキチン化はNF-κB活性化を導く2009
- Author(s)
  徳永文稔
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20059031
[Presentation] Linear ubiquitination : a novel type of polyubiquitin chain for NF-κB activatio(Invited Lecture).2009
- Author(s)
  徳永文稔
- Organizer
  第7回血液血管オルビス
- Place of Presentation
  東京
- Year and Date
  2009-08-23
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] 直鎖状ポリユビキチン化:NF-κB活性化を導く新たなポリユビキチン鎖2009
- Author(s)
  徳永文稔
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] 直鎖状ポリュビキチン化:NF-κB活性化を導く新たなポリュビキチン鎖2009
- Author(s)
  徳永文稔
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20059031
[Presentation] NEMOの2分子以上の直鎖状ポリユビキチン化はNF-KB活性化を導く2009
- Author(s)
  徳永文稔
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] polyubiquitination : A newly identified regulator of NF-κB signaling.2009
- Author(s)
  Iwai, K., Tokunaga, F.Linear
- Organizer
  The EMBO Conference "Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation"
- Place of Presentation
  Riva Del Garda, Italy.
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] 直鎖状ポリユビキチン化:NF-κB活性化を導く新たなポリユビキチン鎖(ワークショップ)2009
- Author(s)
  徳永文稔、中川朋子、坂田真一、岩井一宏
- Organizer
  第32回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] NEMOの2分子以上の直鎖状ポユビキチン化はNF-κB活性化を導く2009
- Author(s)
  徳永文稔
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21657028
[Presentation] 新規直鎖状ポリユビキチン鎖生成を介するNF-κB経路の活性化(シンポジウム)2009
- Author(s)
  徳永文稔
- Organizer
  第19回WSフォーラム-タンパク質・ペプチド研究の現状と展望-
- Place of Presentation
  福岡
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] 直鎖状ポリユビキチン化:NF-κB活性化に必須な新たなユビキチン修飾系(シンポジウム)2009
- Author(s)
  徳永文稔、岩井一宏
- Organizer
  第1回シグナルネットワーク研究会
- Place of Presentation
  東京
- Year and Date
  2009-05-29
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] The COP9/Signalosome increases the efficiency of pVHL-containing ubiquitin ligase.mediated HIF-α ubiquitination.2008
- Author(s)
  Miyauchi, Y., Kato, M., Tokunaga, F., Iwai, K.
- Organizer
  ZOMESV : The Fifth International Symposium on the COP9 signalosome, Proteasome and eIF3 : At the interface between signaling and proteolysis(Invited)
- Place of Presentation
  Yokohama, Japan.
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] LUBACユビキチンリガーゼによるNEMOの直鎖状ポリユビキチン化修飾とNF-kB活性化の分子機構2008
- Author(s)
  徳永文稔
- Organizer
  第31回日本分子生物学会、第81回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] The COP9/Signalosorne increases the efficiency of pVHL-containing ubiquitin ligase-mediated H1F-a ubiquitination2008
- Author(s)
  Miyauchi, Y., Kato, M., Tokunaga, F., lwai K.
- Organizer
  ZOMESV
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] LUBACュビキチンリガーゼによるNEMOの直鎖状ポリュビキチン化修飾とNF-kB活性化の分子機構2008
- Author(s)
  徳永文稔
- Organizer
  第31回日本分子生物学会、第81回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-19657035
[Presentation] LUBACユビキチンリガーゼによるMEMOの直鎖状ポリユビキチン化修飾とNF-κB活性化の分子機構2008
- Author(s)
  徳永文稔
- Organizer
  第31回日本分子生物学会、第81回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20059031
[Presentation] LUBACユビキチンリガーゼによるNEMOの直鎖状ポリユビキチン化修飾とNF-κB活性化の分子機構2008
- Author(s)
  徳永文稔、坂田真一、佐伯泰、亀井希代子、中川朋子、山岡昇司、山本雅裕、審良静男、高尾敏文、田中啓二、岩井一宏
- Organizer
  BMB2008
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] LUBACユビキチンリガーゼによるNEMOの直鎖型ポリユビキチン化修飾とNF-κB活性化2007
- Author(s)
  徳永文稔
- Organizer
  第30回日本分子生物学会年会、第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19657035
[Presentation] Linear ubiquitination of NEMO triggers NF-kB activation.2007
- Author(s)
  Tokunaga, F., Sakata, S.-I., Kirisako, T., Nakagawa, T., Murata, S.Tanaka, K.Iwai, K.
- Organizer
  The EMBO Conference "Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation"
- Place of Presentation
  Riva Del Garda, Italy.
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] Linear ubiquitination of NEMO triggers NF-KB activation2007
- Author(s)
  Tokunaga, F., Sakata, S.-I., Kirisako, T., Nakagawa, T., Murata, S. Tanaka, K. and Iwai, K.
- Organizer
  The EMBO Conference "Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation"
- Place of Presentation
  Riva Del Garda Italy
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] Linear ubiquitination of NEMO triggers NF-kB activation2007
- Author(s)
  Tokunaga, F., et. al.
- Organizer
  EMBO CONFERENCE Ubiquitin and Ubiqutin-like Modifiers in Cellular Reeulation
- Place of Presentation
  Riva Del Garda, Italy
- Year and Date
  2007-09-24
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] Identification of a ligase complex polymerizing linear polyubiquitin chains and its physiological role.2006
- Author(s)
  Kirisako, T., Tokunaga, F., Nakamura, M., Iwai, K.
- Organizer
  The Fourth NIBB-EMBL Symposium,(Invited)
- Place of Presentation
  Okazaki, Japan.
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] Linear ubiquitination-mediated NF-κB regulation mechanism and its related disorders
- Author(s)
  Fuminori Tokunaga
- Organizer
  プロテイン・アイランド・松山(PIM)国際シンポジウム2013
- Place of Presentation
  松山
- Invited
- Data Source
  KAKENHI-PROJECT-25670137
[Presentation] 直鎖状ポリユビキチン化を介したNF-κB制御と疾患
- Author(s)
  徳永文稔
- Organizer
  第86回日本生化学会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] 直鎖状ユビキチン鎖生成を介したNF-κBシグナル制御と疾患
- Author(s)
  徳永文稔
- Organizer
  東京工業大学バイオサイエンスシンポジウム
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] Linear ubiquitination-mediated NF-κB regulation mechanism and its related disorders
- Author(s)
  Fuminori Tokunaga
- Organizer
  プロテイン・アイランド・松山(PIM)国際シンポジウム2013
- Place of Presentation
  松山
- Invited
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] Down-regulation mechanism for LUBAC-induced NF-κB pathway
- Author(s)
  Fuminori Tokunaga
- Organizer
  The 35th Naito Conference: The ubiquitin-proteasome system: From basic mechanisms to pathophysiological roles
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-25670137
[Presentation] 直鎖状ユビキチン鎖生成を介したNF-κBシグナル制御と疾患
- Author(s)
  徳永文稔
- Organizer
  東京工業大学バイオサイエンスシンポジウム
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-25670137
[Presentation] ユビキチン修飾による細胞機能制御と疾患
- Author(s)
  徳永文稔
- Organizer
  第60回北関東医学会総会
- Place of Presentation
  前橋
- Invited
- Data Source
  KAKENHI-PROJECT-25670137
[Presentation] 直鎖状ポリユビキチン化を介したNF-κB制御と疾患
- Author(s)
  徳永文稔
- Organizer
  第86回日本生化学会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] 直鎖状ユビキチン鎖生成を介したNF-κBシグナル制御と疾患
- Author(s)
  徳永文稔
- Organizer
  東京工業大学バイオサイエンスシンポジウム
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] Linear ubiquitination-mediated NF-κB regulation mechanism and its related disorders
- Author(s)
  Fuminori Tokunaga
- Organizer
  プロテイン・アイランド・松山(PIM)国際シンポジウム2013
- Place of Presentation
  松山
- Invited
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] 直鎖状ユビキチン化を介するNF-κB制御に関わる脱ユビキチン化酵素と疾患
- Author(s)
  徳永文稔、西増弘志、石谷隆一郎、濡木理
- Organizer
  病態プロテアーゼ学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] Down-regulation mechanism for LUBAC-induced NF-κB pathway
- Author(s)
  Fuminori Tokunaga
- Organizer
  The 35th Naito Conference: The ubiquitin-proteasome system: From basic mechanisms to pathophysiological roles
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] ユビキチン修飾による細胞機能制御と疾患
- Author(s)
  徳永文稔
- Organizer
  第60回北関東医学会総会
- Place of Presentation
  前橋
- Invited
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] 直鎖状ポリユビキチン修飾を介したNF-κB制御のB細胞リンパ腫発症における役割
- Author(s)
  徳永文稔
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] 直鎖状ユビキチン化を介するNF-κB制御に関わる脱ユビキチン化酵素と疾患
- Author(s)
  徳永文稔、西増弘志、石谷隆一郎、濡木理
- Organizer
  病態プロテアーゼ学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25670137
[Presentation] 直鎖状ユビキチン化を介するNF-κB制御に関わる脱ユビキチン化酵素と疾患
- Author(s)
  徳永文稔、西増弘志、石谷隆一郎、濡木理
- Organizer
  病態プロテアーゼ学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PLANNED-22117006
[Presentation] 直鎖状ポリユビキチン化を介したNF-κB制御と疾患
- Author(s)
  徳永文稔
- Organizer
  第86回日本生化学会　シンポジウム
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-25670137
[Presentation] 直鎖状ポリユビキチン修飾を介したNF-κB制御のB細胞リンパ腫発症における役割
- Author(s)
  徳永文稔
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] ユビキチン修飾による細胞機能制御と疾患
- Author(s)
  徳永文稔
- Organizer
  第60回北関東医学会総会
- Place of Presentation
  前橋
- Invited
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] Down-regulation mechanism for LUBAC-induced NF-κB pathway
- Author(s)
  Fuminori Tokunaga
- Organizer
  The 35th Naito Conference: The ubiquitin-proteasome system: From basic mechanisms to pathophysiological roles
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-23390070
[Presentation] 直鎖状ポリユビキチン修飾を介したNF-κB制御のB細胞リンパ腫発症における役割
- Author(s)
  徳永文稔
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-25670137

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35. KOMATSU masaaki

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Tokunaga Fuminori 徳永 文稔

TOKUNAGA Fuminori 徳永 文稔

Research Projects

Research Products

Co-Researchers

複雑化直鎖状ユビキチンコードを介した炎症・免疫制御の包括的研究Principal InvestigatorOngoing

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Construction of DUB MAP for innate immune and inflammatory responsesPrincipal InvestigatorOngoing

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直鎖状ユビキチン鎖を介した生体防御応答の制御とその破綻に伴う疾患発症Ongoing

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水疱性類天疱瘡における炎症誘起機序の解明と新たな治療法の開発応用Ongoing

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炎症・免疫シグナル制御に関与する２種の新規ユビキチンリガーゼの解析Principal InvestigatorOngoing

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Involvement of linear ubiquitination in mitophagyPrincipal Investigator

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Spatiotemporal regulation of Inflammation and immune signals by ubiquitination and its mathematical simulationOngoing

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Identification of deubiquitinases, which regulate inflammatory and immune signaling pathways, and screening for their inhibitorsPrincipal Investigator

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Regulation of cellular signal transduction by novel immunological factor

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新規LUBAC結合性ユビキチンリガーゼの機能解析Principal Investigator

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Screening for interactors of linear ubiquitin chain assembly complex (LUBAC), and studies on their physiological functionsPrincipal Investigator

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Construction and application of linear ubiquitin-specific molecular probes for anti-cancer drug screeningPrincipal Investigator

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Investigation of physiological function of linear polyubiquitination using various biological modelsPrincipal Investigator

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Tokunaga Fuminori 徳永文稔

TOKUNAGA Fuminori 徳永文稔