AIBAK Tetsuya 合葉哲也

Researcher Number	00231754
Other IDs
Affiliation (Current)	2023: 岡山大学, 医歯薬学域, 准教授
Affiliation (based on the past Project Information) *help	2021: 岡山大学, 医歯薬学域, 准教授 2016 – 2020: 岡山大学, 医歯薬学総合研究科, 准教授 2012 – 2015: 岡山大学, 医歯(薬)学総合研究科, 准教授 2014: 岡山大学, 大学院医歯薬学総合研究科, 准教授 2007 – 2011: Okayama University, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Ph.D.Associate Profrssor … More 2010: 岡山大学, 大学院・医歯学総合研究科, 准教授 2008: 岡山大学, 医歯薬学総合研究科, 准教授 2006: 岡山大学, 大学院・医歯薬学総合研究科, 助教授 2005: 岡山大学, 大学院医歯薬学総合研究科, 助教授 2000 – 2004: Toyama Medical and Pharmaceutical University Graduate School of Pharmaceutical Sciences Associate Professor, 大学院・薬学研究科, 助教授 2000: 富山医科薬科大学, 薬学研究科, 助教授 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Medical pharmacy / 応用薬理学・医療系薬学 / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator 腎不全 / 投与設計 / PK/PD / 中枢神経系 / 個別化医療 / 腎障害 / 肝代謝 / NKCC1 / 炎症 / 薬効変動 … More / 薬物代謝酵素 / 発現変動 / 脈絡叢 / 中枢神経 / CYP3A / テーラーメード医療 / CYP3A2 / 個体差 / 薬物感受性 / 薬物療法 / 代謝 / 睡眠薬 / 鎮静薬 / 薬物速度論 / 薬物動態 / 向精神薬 / ファーナコキネティクス / セファレキシン / トルブタミド / キニジン / TRPV1 / ファーマコダイナミクス / 消化管神経叢 / 尿毒症物質 / アベイラビリティ / 腹膜透析 / タンパク結合 / 分布容積 / Renal failure / Pharmacokinetics / Cephalexin / Tolhutamide / unidine / NKCCl / TRPVl / Pharmacodynamics / 個別化投与 / 中枢抑制 / 神経栄養因子受容体 / GABA / PKPD / 中枢抑制作用 / 抗不安薬 … More Except Principal Investigator 薬物動態 / 微小透析 / マイクロダイアリシス / バイオアベイラビリティ / CYP3A4 / 小腸 / bioavailability / CYP3A / ドラッグデリバリー / 薬物送達 / 局所 / 筋肉 / トランスポータ / P-糖蛋白質 / タクロリムス / tacrolimus / プロプラノロール / 腎障害 / 初回通過効果 / CYP2D6 / renal failure / P450 / 製剤学 / 限局 / 局所動態 / モニタリング / Lipo-MD / 血流 / lipo-MD / 局所薬物動態 / 局所利用率 / ドドラッグデリバリーシステム / ファーマコキネティクス / 拡散モデル / 筋肉内薬物拡散動態 / 局所冷却 / 遊離形薬物濃度 / 時間遅れ補正 / 吸着動態 / 筋肉内拡散動態 / 局所血流 / 微小透析（マイクロダイアリシス） / 代謝 / transporter / P-glycoprotein / metabolism / intestine / 小腸代謝 / 肝初回通過効果 / アジマリン / タクロスリム / propranolol / intestinal metabolism / first-pass effect / ajmaline / 肝代謝 / 小腸吸収速度 / 薬物吸収 / CYP2D / hepatic metabolism / intestinal absorption / first-pass clearance / 心不全 / β遮断薬 / 薬物体内動態 / 人種差 / カルベジロール / ビソプロロール / メトプロロール / heart failure / β-blocker / pharmacokinetics / NAFLD/NASH / RNAメチル化 / インフラマソーム / エピジェネティクス / 酸化ストレス / 自己炎症 / 食習慣 / ミトコンドリア / 偏栄養 / ALKBH / RNAエピジェネティックス / 栄養エネルギー代謝 / RNA / 慢性炎症 / 異所性脂肪 / NASH / 腸管上皮バリア / エピジェネティック Less

Dosage individualization of antianxiety and sedative medication based on modified synaptic function of cerebral GABAergic neurons with peripheral organs failurePrincipal Investigator
- Principal Investigator
  
  合葉哲也
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Okayama University
Elucidation of liver mitochondrial failure and autoinflammation with RNA-epigenetics caused by nutrient stress
- Principal Investigator
  
  TAKAYAMA Fusako
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Okayama University
Mechanism underlying potentiated pharmacological effects of sedatives with renal failurePrincipal Investigator
- Principal Investigator
  
  AIBA TETSUYA
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Dose optimization of the central nervous system acting compound considering its altered pharmacokinetics and pharmacodynamics in patients with acute renal failurePrincipal Investigator
- Principal Investigator
  
  AIBA TETSUYA
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Evaluation of focal availabilities of drugs by monitoring of dynamic diffusion and clearance processes of unbound drug concentrations
- Principal Investigator
  
  KUROSAKI Yuji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Understanding mechanisms underlying an increased sensitivity of central nervous system to therapeutic compounds with decreased renal function for dose optimization and individualizing treatmentPrincipal Investigator
- Principal Investigator
  
  AIBA Tetsuya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Application of microdialysis techniques to evaluation system for local pharmacokinetics of topically delivered drugs guaranteeing regionally confined drug action
- Principal Investigator
  
  KUROSAKI Yuji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Evaluation system for local pharmacokinetics of topically delivered drugs guaranteeing regionally confined drug action
- Principal Investigator
  
  KUROSAKI Yuji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Mechanisms responsible for interindividual variability of bioavailability of therapeutic compounds in patients with acute renal failure and related homeostasis perturbationPrincipal Investigator
- Principal Investigator
  
  AIBA Tetsuya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
Mechanism of the pharmacokinetic variability and race difference of β-blockers
- Principal Investigator
  
  HASHIMOTO Yukiya
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Mechanisms of The Increased Bioavailability of Drugs During Renal Failure
- Principal Investigator
  
  HASHIMOTO Yukiya
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
Interplay between in tasting and liver for the first-pass metabolism of orally administered drugs
- Principal Investigator
  
  HASHIMOTO Yukiya
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
Analysis of barrier function of intestinal drug-metabolizing enzymes and transporters
- Principal Investigator
  
  YUKIYA Hashimoto
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
  Kyoto University

[Journal Article] Acute Peripheral Inflammation Increases Plasma Concentration of Hypoglycemic Agent Nateglinide with Decreased Hepatic Drug-Metabolizing Activity in Rats2021
- Author(s)
  Kojina Moeko、Suzuki Keiichiro、Nishiwaki Akane、Aiba Tetsuya
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 44 Issue: 1 Pages: 96-102
- DOI
  10.1248/bpb.b20-00677
- NAID
  130007965329
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Data Source
  KAKENHI-PROJECT-19K07220
[Journal Article] Effects of dexamethasone to reverse decreased hepatic midazolam metabolism in rats with acute renal failure2019
- Author(s)
  Doi Masami、Kajikawa Noriko、Aiba Tetsuya
- Journal Title
  
  Xenobiotica
  
  Volume: 50 Pages: 506-514
- DOI
  10.1080/00498254.2019.1655680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07220
[Journal Article] <i>In Vivo</i> Study on Mechanism Underlying Increased Pharmacological Effects of Phenobarbital in Rats with Glycerol-Induced Acute Renal Failure2019
- Author(s)
  Okada A, Suzuki K, Hara K, Kojina M, Aiba T
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 42 Issue: 3 Pages: 501-506
- DOI
  10.1248/bpb.b18-00659
- NAID
  130007607259
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08097
[Journal Article] Altered hepatic drug-metabolizing activity in rats suffering from hypoxemia with experimentally induced acute lung impairment2018
- Author(s)
  Hori Y, Shimizu Y, Aiba T
- Journal Title
  
  Xenobiotica
  
  Volume: 48 Pages: 576-583
- DOI
  10.1080/00498254.2017.1349969
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08097
[Journal Article] Interspecies comparison of hepatic metabolism of six newly synthesized retinoid X receptor agonistic compounds possessing a 6-[N-ethyl-N-(alkoxy isopropylphenyl) amino]nicotinic acid skeleton in rat and human liver microsomes2014
- Author(s)
  Murakami Y, Shimizu Y, Ogasawara A, Ueshima S, Nakayama M, Kawata K, Kakuta H, Aiba T.
- Journal Title
  
  Drug Dev. Ind. Pharm.
  
  Volume: 40 Pages: 1065-1071
- DOI
  10.3109/03639045.2013.807278
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590192
[Journal Article] Effect of Carrageenan-induced Acute Peripheral Inflammation on the Pharmacokinetics and Hepatic Metabolism of Midazolam in Rats2014
- Author(s)
  Kajikawa N, Doi M, Kusaba J-I, Aiba T.
- Journal Title
  
  DMPK
  
  Volume: 29 Issue: 5 Pages: 400-406
- DOI
  10.2133/dmpk.dmpk-14-rg-020
  10.2133/dmpk.DMPK-14-RG-020
- NAID
  130004463401
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590192
[Journal Article] Effect of carrageenan-induced acute peripheral inflammation on the electrolyte disposition to cerebrospinal fluid in rats2013
- Author(s)
  Kono K, Okada A, Ishikawa A, Aiba T.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 36 Pages: 1829-1834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590192
[Journal Article] The effects of body weight and combination drug therapy on the serum concentrations of zonisamide in 94 epileptic dogs: An epidemiological analysis2012
- Author(s)
  Fukunaga K, Aiba T, Saitos M, Muto M, Watanabe N, Uchida K, Okuno S, Kobayashu T, Orito K.
- Journal Title
  
  The International Journal of Applied Research in Veterinary Medicine
  
  Volume: 10 Pages: 258-263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590192
[Journal Article] In vivo application of chitosan to facilitate intestinal acyclovir absorption in rats2012
- Author(s)
  Masuda A, Goto Y, Kurosaki Y, Aiba T.
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 101 Pages: 2499-2456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590192
[Journal Article] Comparative study on altered hepatic metabolism of CYP3A substrates in rats with glycerol-induced acute renal failure2012
- Author(s)
  Kusaba J-I, Kajikawa N, Kawasaki H, Kurosaki Y, Aiba T
- Journal Title
  
  Biopharm Drug Dispos
  
  Volume: 33 Pages: 22-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590159
[Journal Article] 薬物の筋肉内拡散・分布動態に及ぼす血流量の影響:局所冷却時の動態特性2011
- Author(s)
  牧之段敬一, 東恩納司, 村上仁美, 合葉哲也, 黒崎勇二
- Journal Title
  
  日本薬剤学会第26年会講演要旨集
  
  Pages: 141-141
- Data Source
  KAKENHI-PROJECT-21590161
[Journal Article] Pharmacodynamic characterization of nitric oxide-mediated vasodilatory activity in isolated perfused rat mesenteric artery bed2011
- Author(s)
  Inoue S, Aiba T, Masaoka Y, Shimizu K, Komori Y, Mio M, Takatori S, Kawasaki H, Kurosaki Y
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 34 Pages: 1487-1492
- NAID
  130001872445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590159
[Journal Article] Pharmacodynamic characterization of nitric oxide-mediated vasodilatory activity in isolated perfused rat mesenteric artery bed2011
- Author(s)
  Shinnsuke Inoue, Tetsuya Aiba, Yasuyuki Masaoka, Keiko Shimizu, Yukiko Komori, Mitsunobu Mio, Shingo Takatori, Hiromu Kawasaki, Yuji Kurosaki
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 34(9) Pages: 1487-1492
- NAID
  130001872445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590161
[Journal Article] 脂肪乳剤を用いた微小透析法(Lipo-MD法):薬物の脂溶性が透析特性に及ぼす影響2010
- Author(s)
  岡大嗣, 小林徹, 合葉哲也, 黒崎勇二
- Journal Title
  
  第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会講演要旨集
  
  Pages: 187-187
- Data Source
  KAKENHI-PROJECT-21590161
[Journal Article] Microdialysis study in evaluation of intramuscular lateral distribution profiles of topically administered drugs inrats2010
- Author(s)
  Tsukasa Higashionna, Hitomi Murakami, Keiichi Makinodan, Kozue Kanda, Mayu Shibata, Tetsuya Aiba, Yuji Kurosaki
- Journal Title
  
  25th JSSX Annual Meetingin Tokyo Abstracts
  
  Pages: 219-219
- Data Source
  KAKENHI-PROJECT-21590161
[Journal Article] Altered electrolyte handling of the choroid plexus in rats with glycerol-induced acute renal failure2010
- Author(s)
  Ishikawa A, Kono K, Sakae R, Aiba T, Kawasaki H, Kurosaki Y
- Journal Title
  
  Biopharm Drug Dispos
  
  Volume: 31 Pages: 455-463
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590159
[Journal Article] 血管平滑筋弛緩作用の薬力学モデル解析2010
- Author(s)
  合葉哲也, 井上真輔, 正岡康幸, 清水けい子, 小森有希子, 高取真吾, 見尾光庸, 川崎博己, 黒崎勇二
- Journal Title
  
  日本薬学会第130年会要旨集
  
  Volume: 4 Pages: 265-265
- Data Source
  KAKENHI-PROJECT-21590161
[Journal Article] 脂肪乳剤を用いた微小透析法(Lipo-MD法)の透析特性:濃度変化に対する追随性の従来法との比較2009
- Author(s)
  小林徹, 合葉哲也, 黒崎勇二
- Journal Title
  
  第48回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会講演要旨集
  
  Pages: 113-113
- Data Source
  KAKENHI-PROJECT-21590161
[Journal Article] Comparative study of increased plasma quinidine concentration in rats with glycerol-and cisplatin-induced acute renal failure2009
- Author(s)
  Izuwa Y, Kusaba J-I, Horiuchi M, Aiba T, Kawasaki H, Kurosaki Y
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 24 Pages: 451-457
- NAID
  10025724709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590159
[Journal Article] Evaluation of intramuscular lateral distribution profile of topically administered acetaminophen in rats2007
- Author(s)
  Yuji Kurosaki, Masahiro Tagawa, Akiho Omoto, Hiroshi Suito, Yukiko Komori, Hiromu Kawasaki, Tetsuya Aiba
- Journal Title
  
  Int. J. Pharm. 343(1-2)
  
  Pages: 190-195
- NAID
  120002307079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590143
[Journal Article] Peritoneal dialysis alters tolbutamide pharmacokinetics in rats with experimental acute renal failure2006
- Author(s)
  Tetsuya, Aiba, et. al.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 21(4)
  
  Pages: 291-296
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590141
[Journal Article] Peritoneal dialysis alters tolbutamide pharmacokinetics in rats with experimental acute renal failure2006
- Author(s)
  Tetsuya Aiba, et. al.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 21
  
  Pages: 291-296
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590141
[Journal Article] Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in Caco-2 cell monolayers.2005
- Author(s)
  Aiba, Tetsuya
- Journal Title
  
  Biol.Pharm.Bull. 28・1
  
  Pages: 114-119
- Data Source
  KAKENHI-PROJECT-15590126
[Journal Article] Pharmacokinetic characterization of transcellular transport and drug interaction of diaoxin in Caco-2 cell monolayers.2005
- Author(s)
  Aiba, Tetsuya
- Journal Title
  
  Biol.Pharm.Bull. 28・1
  
  Pages: 114-119
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590126
[Journal Article] Intestinal expression and metabolic activity of the CYP3A subfamily in fem-ale rats.2005
- Author(s)
  Aiba, Tetsuya
- Journal Title
  
  Biol.Pharm.Bull. 28(2)
  
  Pages: 311-315
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590126
[Journal Article] Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in Caco-2 cell monolayers.2005
- Author(s)
  Aiba, Tetsuya
- Journal Title
  
  Biol.Pharm.Bull. 28(1)
  
  Pages: 114-119
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590126
[Journal Article] Intestinal expression and metabolic activity of the CYP3A subfamily in female rats.2005
- Author(s)
  Aiba, Tetsuya
- Journal Title
  
  Biol.Pharm.Bull. 28・2
  
  Pages: 311-315
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590126
[Journal Article] Poor correlation between intestinal and hepatic metabolic rates of CYP3A4 substrates in rats.2003
- Author(s)
  Aiba, Tetsuya
- Journal Title
  
  Pharm.Res. 20・5
  
  Pages: 745-748
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590126
[Journal Article] Poor correlation between intestinal and hepatic metabolic rates of CYP3A4 substrates in rats.2003
- Author(s)
  Aiba, Tetsuya
- Journal Title
  
  Pharm.Res. 20(5)
  
  Pages: 745-748
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590126
[Presentation] フェノバルビタールの薬効発現における脳中枢神経系の薬力学的感受性亢進因子2022
- Author(s)
  竹中美沙、松本和也、青江知佳、鈴木啓一郎、合葉哲也
- Organizer
  日本薬学会第１４２年会
- Data Source
  KAKENHI-PROJECT-19K07220
[Presentation] 経口血糖降下薬ナテグリニドの薬効発現に及ぼす炎症の影響2022
- Author(s)
  村井七海、床治佳、荻野愛美、西脇あかね、合葉哲也
- Organizer
  日本薬学会第１４２年会
- Data Source
  KAKENHI-PROJECT-19K07220
[Presentation] 炎症病態に伴う血糖降下薬ナテグリニドの薬効変動の解析2020
- Author(s)
  西脇あかね, 床治佳, 神志那萌子, 松本和也, 合葉哲也
- Organizer
  日本薬学会第１４０年会
- Data Source
  KAKENHI-PROJECT-19K07220
[Presentation] 急性腎不全に伴うフェノバルビタールの中枢抑制作用の薬力学的変動機構2020
- Author(s)
  松本和也, 鈴木敬一郎, 西脇あかね, 合葉哲也
- Organizer
  日本薬学会第１４０年会
- Data Source
  KAKENHI-PROJECT-19K07220
[Presentation] 急性腎不全ラットにおける中枢神経系抑制薬の薬効増強メカニズムの検討2019
- Author(s)
  松本和也, 鈴木啓一郎, 合葉哲也
- Organizer
  第５８回日本薬学会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-19K07220
[Presentation] 急性組織炎症病態における糖尿病治療薬ナテグリニドの体内動態と薬効解析2018
- Author(s)
  神志那萌子、西脇あかね、鈴木啓一郎、藤本和貴、合葉哲也
- Organizer
  第28回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-15K08097
[Presentation] 急性局所炎症モデルラットにおける糖尿病治療薬ナテグリニドの体内動態の変動メカニズム2018
- Author(s)
  神志那萌子、鈴木啓一郎、藤本和貴、合葉哲也
- Organizer
  日本薬学会第１３８年会
- Data Source
  KAKENHI-PROJECT-15K08097
[Presentation] 中枢神経抑制薬の麻酔作用に及ぼす末梢組織炎症の影響2018
- Author(s)
  鈴木啓一郎、岡田淳芳、原啓介、松本和也、神志那萌子、合葉哲也
- Organizer
  第28回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-15K08097
[Presentation] 急性腎不全に伴う中枢神経系の薬物感受性の変動と電解質平衡調節機構の変動2018
- Author(s)
  鈴木啓一郎、岡田淳芳、原啓介、神志那萌子、合葉哲也
- Organizer
  日本薬学会第１３８年会
- Data Source
  KAKENHI-PROJECT-15K08097
[Presentation] 急性腎不全モデルラットにおけるフェノバルビタールの薬効変動機構の解明2017
- Author(s)
  原啓介、岡田淳芳、鈴木啓一郎、合葉哲也
- Organizer
  日本薬学会第１３7年会
- Place of Presentation
  宮城県仙台市青葉区青葉山国際センター
- Data Source
  KAKENHI-PROJECT-15K08097
[Presentation] 急性腎不全ラットにおける中枢神経系作用薬の薬効変動メカニズム2016
- Author(s)
  鈴木啓一郎、原啓介、岡田淳芳、合葉哲也
- Organizer
  第５５回日本薬学会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  岡山県岡山市中区西川原　就実大学
- Data Source
  KAKENHI-PROJECT-15K08097
[Presentation] Alteration of the pharmacological effects of the CNS-acting compounds in rats with acute renal failure2015
- Author(s)
  原啓介、岡田淳芳、合葉哲也
- Organizer
  第３０回日本薬物動態学会年会
- Place of Presentation
  東京都江戸川区
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-15K08097
[Presentation] An increased hepatic drug metabolizing activity accompanied with experimentally induced lung impairment and hypoxemia in rats2015
- Author(s)
  堀友紀、清水康正、合葉哲也
- Organizer
  第３０回日本薬物動態学会年会
- Place of Presentation
  東京都江戸川区
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-15K08097
[Presentation] 急性腎不全ラットにおける肝臓の薬物代謝酵素の発現調節機構の変調2015
- Author(s)
  藤本和貴、土居雅美、梶川典子、原啓介、合葉哲也
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  神戸市
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-24590192
[Presentation] Acute renal failure alters the induced mRNA expression of hepatic CYP3A subfamily in rats2014
- Author(s)
  Doi M, Fujimoto K, Kajikawa N, Aiba T.
- Organizer
  19th North American ISSX / 29th JSSX Joint Meeting
- Place of Presentation
  サンフランシスコ市（米国）
- Year and Date
  2014-10-20
- Data Source
  KAKENHI-PROJECT-24590192
[Presentation] ラット肝薬物代謝酵素の発現誘導に及ぼす急性腎不全の影響2014
- Author(s)
  藤本和貴、土居雅美、梶川典子、合葉哲也
- Organizer
  第５３回日本薬学会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  広島市
- Year and Date
  2014-11-08
- Data Source
  KAKENHI-PROJECT-24590192
[Presentation] Altered hepatic drug metabolizing activity in rats with acute lung impairment2014
- Author(s)
  Hori Y, Shimizu Y, Aiba T.
- Organizer
  19th North American ISSX / 29th JSSX Joint Meeting
- Place of Presentation
  サンフランシスコ市（米国）
- Year and Date
  2014-10-20
- Data Source
  KAKENHI-PROJECT-24590192
[Presentation] Altered pharmacological potency of the CNS-acting compounds in rats with acute renal failure2014
- Author(s)
  Aiba T, Kono Y, Okada A, Kono K, Shinomiya K.
- Organizer
  19th North American ISSX / 29th JSSX Joint Meeting
- Place of Presentation
  サンフランシスコ市（米国）
- Year and Date
  2014-10-21
- Data Source
  KAKENHI-PROJECT-24590192
[Presentation] 遊離形薬物濃度モニタに基づく筋肉内局所利用率の評価：局所冷却時のin vivo拡散モデルによる数理的解析2013
- Author(s)
  宇都野侑史、牧之段敬一、長永淳史、合葉哲也、黒﨑勇二
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-24590193
[Presentation] 遊離形薬物濃度モニタに基づく筋肉内局所利用率の評価：局所冷却時のin vivo拡散モデルによる数理的解析.2013
- Author(s)
  宇都野侑史、牧之段敬一、長永淳史、合葉哲也、黒﨑勇二
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-24590193
[Presentation] ラット脳脊髄液の電解質平衡調節機構に及ぼす急性炎症の影響2012
- Author(s)
  岡田淳芳、合葉哲也、, 他5名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌市
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-21590159
[Presentation] 新規RXRアゴニスト及びその類縁化合物のヒト肝における代謝特性の予測2012
- Author(s)
  合葉哲也
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590159
[Presentation] Evaluation of dynamic diffusion process for developing focally acting DDSs: Improvement of focal bioavailability by topical cooling.2012
- Author(s)
  Atsushi Osanaga, Keiichi Makinodan, Tatsuya Sakiyama, Tetsuya Aiba, Yuji Kurosaki
- Organizer
  第6回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-24590193
[Presentation] Microdialysis法を用いた薬物の筋肉内局所動態評価:局所冷却による局所薬物利用率の増大.2012
- Author(s)
  牧之段敬一、東恩納司、崎山達矢、合葉哲也、黒﨑勇二
- Organizer
  第28回日本DDS学会学術集会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-24590193
[Presentation] ラットにおける薬物肝代謝酵素の発現に及ぼす急性腎不全の影響2011
- Author(s)
  梶川典子、合葉哲也、, 他3名
- Organizer
  日本薬学会第131年会
- Data Source
  KAKENHI-PROJECT-21590159
[Presentation] Effect of acute inflammation on lithium disposition to cerebrospinal fluid inrats2011
- Author(s)
  河野健太郎、合葉哲也、, 他5名
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  広島市
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21590159
[Presentation] 急性炎症に伴う電解質の脳脊髄液移行特性の変動評価2011
- Author(s)
  岡田淳芳、合葉哲也、, 他5名
- Organizer
  第50回日本薬学会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  高松市
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-21590159
[Presentation] 薬物の筋肉内拡散・分布動態に及ぼす血流量の影響:局所冷却時の動態特性2011
- Author(s)
  牧之段敬一, 東恩納司, 村上仁美, 合葉哲也, 黒崎勇二
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] Microdialysis study in evaluation of intramuscular lateral distribution profiles of topically administered drugs in rats2010
- Author(s)
  Tsukasa Higashionna, Hitomi Murakami, Keiichi Makinodan, Kozue Kanda, Mayu Shibata, Tetsuya Aiba, Yuji Kurosaki
- Organizer
  日本薬物動態学会第25回年会(25th JSSX Annual Meeting in Tokyo)
- Place of Presentation
  大宮ソニックシティ
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] Altered drug metabolizing activity of hepatic CYP3A subfamily in rats with acute renalfailure2010
- Author(s)
  草場潤一、合葉哲也、, 他4名
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  大宮市
- Year and Date
  2010-10-06
- Data Source
  KAKENHI-PROJECT-21590159
[Presentation] Microdialysis study in evaluation of intramuscular lateral distribution profiles of topically administered drugs in rats2010
- Author(s)
  TsukasaHigashionna, Hitomi Murakami, Keiichi Makinodan, Kozue Kanda, Mayu Shibata, Tetsuya Aiba, Yuji Kurosaki
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] 血管平滑筋弛緩作用の薬力学モデル解析2010
- Author(s)
  合葉哲也, 井上真輔, 正岡康幸, 清水けい子, 小森有希子, 高取真吾, 見尾光庸, 川崎博己, 黒崎勇二
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山市
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] 急性腎不全ラットにおける薬物肝代謝活性の変動評価2010
- Author(s)
  草場潤一、合葉哲也、, 他3名
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山市
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590159
[Presentation] 脂肪乳剤を用いた微小透析(Lipo-MD法):薬物の脂溶性が透析特性に及ぼす影響2010
- Author(s)
  岡大嗣、小林徹、合葉哲也、黒崎勇二
- Organizer
  第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  米子コンベンションセンター、米子市文化ホール
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] ラットにおける薬物肝代謝活性に及ぼす急性腎不全の影響2010
- Author(s)
  梶川典子、合葉哲也、, 他4名
- Organizer
  第49回日本薬学会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  米子市
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-21590159
[Presentation] 脂肪乳剤を用いた微小透析法(Lipo-MD法):薬物の脂溶性が透析特性に及ぼす影響2010
- Author(s)
  岡大嗣, 小林徹, 合葉哲也, 黒崎勇二
- Organizer
  第49回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  米子市
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] 血管平滑筋弛緩作用の薬力学モデル解析2010
- Author(s)
  合葉哲也、, 他8名
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山市
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590159
[Presentation] 血管平滑筋弛緩作用の薬力学モデル解析2010
- Author(s)
  合葉哲也
- Organizer
  日本薬学会第130年会
- Place of Presentation
  桃太郎アリーナ(岡山市)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21590159
[Presentation] 脈絡叢におけるCSF電解質濃度の調節機構のin vivo評価2010
- Author(s)
  河野健太郎、合葉哲也、, 他4名
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山市
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21590159
[Presentation] 血管平滑筋弛緩作用の薬力学モデル解析2010
- Author(s)
  合葉哲也、井上真輔、正岡康幸、清水けい子、小森有希子、高取真吾、見尾光康、川崎博己、黒崎勇二
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター(岡山市)
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] 脈絡叢におけるリチウム輸送機構のin vivo解析2009
- Author(s)
  河野健太郎、合葉哲也、, 他5名
- Organizer
  第48回日本薬学会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  松山市
- Data Source
  KAKENHI-PROJECT-21590159
[Presentation] 脂肪乳剤を用いたマイクロダイアリシス法(Lipo-MD法)の局所薬物動態評価への応用2009
- Author(s)
  小林徹、合葉哲也、政田幹夫、黒崎勇二
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡県コンベンションアーツセンター(静岡市)
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] アルベカシンの血中濃度モニタリングにおける腎機能マーカーシスタチンCの有用性評価2009
- Author(s)
  合葉哲也
- Organizer
  第19回日本医療薬学会年会
- Place of Presentation
  長崎ブリックホール(長崎市)
- Year and Date
  2009-10-25
- Data Source
  KAKENHI-PROJECT-21590159
[Presentation] 脂肪乳剤を用いた微小透析法(Lipo-MD法)の透析特性:濃度変化に対する追随性の従来法との比較2009
- Author(s)
  小林徹, 合葉哲也, 黒崎勇二
- Organizer
  第48回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  徳島市
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] Functional investigation of mechanisms responsible for lithium disposition to cerebrospinal fluid in rats2009
- Author(s)
  石川温子、合葉哲也、, 他5名
- Organizer
  第24回日本薬物動態学会年会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-21590159
[Presentation] 脂肪乳剤を用いた微小透析法(Lipo-MD法)の透析特性 : 濃度変化に対する追随性の従来法との比較2009
- Author(s)
  小林徹、合葉哲也、黒崎勇二
- Organizer
  第48回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  アスティ徳島(徳島市)
- Data Source
  KAKENHI-PROJECT-21590161
[Presentation] 微小透析法を用いた薬物の局所動態評価 : フェニレフリンの筋肉内拡散動態と局所血流変化2008
- Author(s)
  柴田麻佑, 神田梢恵, 合葉哲也, 黒崎勇二
- Organizer
  第47回日本薬学会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  岡山市
- Year and Date
  2008-11-09
- Data Source
  KAKENHI-PROJECT-19590143
[Presentation] 微小透析を用いた薬物の筋肉組織内拡散過程の評価2008
- Author(s)
  神田梢恵, 小林徹, 田川真大, 大元章帆, 小森有希子, 合葉哲也, 黒崎勇二
- Organizer
  日本薬剤学会第2 3年会
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-19590143
[Presentation] 微小透析を用いた薬物の局所動態評価 : フェニレフリンの筋肉内拡散動態と局所血流変化2008
- Author(s)
  柴田麻佑, 神田梢恵, 合葉哲也, 黒崎勇二
- Organizer
  第4 7回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  岡山コンベンションセンター
- Data Source
  KAKENHI-PROJECT-19590143
[Presentation] Retrospective analysis of unbound valproate fraction in Japanese epileptic children2007
- Author(s)
  Tetsuya, Aiba, et. al.
- Organizer
  The 28th Annual Meeting of the Japanese Society of Clinical Pharmacology and Therapeutics
- Place of Presentation
  in Utsunomiya City, Tochigi
- Year and Date
  2007-11-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590141
[Presentation] 乳幼児における血中遊離形バルプロ酸の遡及的解析2007
- Author(s)
  合葉哲也, ら
- Organizer
  第28回日本臨床薬理学会年会
- Place of Presentation
  栃木県宇都宮市
- Year and Date
  2007-11-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590141
[Presentation] 急性肺機能障害ラットにおける肝薬物代謝の活性変動
- Author(s)
  堀友紀、清水康正、合葉哲也
- Organizer
  日本薬学会第１３４年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-24590192
[Presentation] 肝ラット肝薬物代謝活性に及ぼす肺障害の影響
- Author(s)
  堀友紀、清水康正、黒﨑勇二、合葉哲也
- Organizer
  第５２回日本薬学会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  松山市
- Data Source
  KAKENHI-PROJECT-24590192
[Presentation] 急性局所炎症に伴う薬物肝代謝活性の変動メカニズムの検討
- Author(s)
  土居雅美、梶川典子、草場潤一、黒﨑勇二、合葉哲也
- Organizer
  日本薬学会第１３３年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24590192
[Presentation] 急性腎不全ラットにおける中枢神経系作用薬の薬効変動機構
- Author(s)
  河野祐輝、岡田淳芳、四宮一昭、合葉哲也
- Organizer
  日本薬学会第１３４年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-24590192
[Presentation] ラット肝CYP3A代謝活性に及ぼす急性局所炎症の影響
- Author(s)
  土居雅美、梶川典子、草場潤一、黒﨑勇二、合葉哲也
- Organizer
  第５１回日本薬学会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  松江市
- Data Source
  KAKENHI-PROJECT-24590192
[Presentation] Effects of acute local inflammation on the hepatic expressions of CYP3A subfamily in rats
- Author(s)
  梶川典子、土居雅美、草場潤一、黒﨑勇二、合葉哲也
- Organizer
  第２７回日本薬物動態学会年会
- Place of Presentation
  東京都江戸川区
- Data Source
  KAKENHI-PROJECT-24590192
[Presentation] ラットにおけるキトサンを用いた難吸収性抗ウイルス薬の消化管吸収改善
- Author(s)
  後藤裕子、舛田あゆみ、黒﨑勇二、合葉哲也
- Organizer
  日本薬剤学会第２７年会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-24590192
[Presentation] Effects of lung impairment on the hepatic drug metabolizing activity in rats
- Author(s)
  清水康正、堀友紀、合葉哲也
- Organizer
  第２８回日本薬物動態学会年会
- Place of Presentation
  東京都江戸川区
- Data Source
  KAKENHI-PROJECT-24590192
[Presentation] Evaluation of the pharmacodynamics of CNS-acting compounds in rats with acute renal failure
- Author(s)
  岡田淳芳、河野健太郎、大谷尚志、四宮一昭、合葉哲也
- Organizer
  第２８回日本薬物動態学会年会
- Place of Presentation
  東京都江戸川区
- Data Source
  KAKENHI-PROJECT-24590192

1. AWASAKI Hiromu (60125151)

# of Collaborated Projects: 5 results

# of Collaborated Products: 9 results
2. KUROSAKI Yuji (90161786)

# of Collaborated Projects: 5 results

# of Collaborated Products: 25 results
3. YUKIYA Hashimoto (90228429)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. KITAMURA Yoshihisa (40423339)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. TAGUCHI Masato (20324056)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. IKUKO Yano (50273446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NOZAWA Takashi (00180737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HONDA Mutsuko (60422630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOMORI Yukiko (80379734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TAKAYAMA Fusako (10236367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 古田和幸 (50644936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 檜垣和孝 (60284080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

AIBAK Tetsuya 合葉 哲也

Research Projects

Research Products

Co-Researchers

Dosage individualization of antianxiety and sedative medication based on modified synaptic function of cerebral GABAergic neurons with peripheral organs failurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism underlying potentiated pharmacological effects of sedatives with renal failurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dose optimization of the central nervous system acting compound considering its altered pharmacokinetics and pharmacodynamics in patients with acute renal failurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Understanding mechanisms underlying an increased sensitivity of central nervous system to therapeutic compounds with decreased renal function for dose optimization and individualizing treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms responsible for interindividual variability of bioavailability of therapeutic compounds in patients with acute renal failure and related homeostasis perturbationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Acute Peripheral Inflammation Increases Plasma Concentration of Hypoglycemic Agent Nateglinide with Decreased Hepatic Drug-Metabolizing Activity in Rats2021

Author(s)

Journal Title

DOI

NAID

ISSN

AIBAK Tetsuya 合葉哲也