ITO Hiroshi 伊藤博

Researcher Number	00232463
Other IDs
Affiliation (based on the past Project Information) *help	2005: Chiba University, Graduate School of Medicine, Associate Professor, 大学病院医学研究院, 助教授 2002 – 2005: Chiba University, Graduate School of Medicine, Associate Professor, 大学院・医学研究院, 助教授 2001: 千葉大学, 大学院・医学研究院, 講師 1999: Chiba University, School of Medicine, Lecturer, 医学部・付属病院, 講師 1999: 千葉大学, 医学部・附属病院, 講師 … More 1998: 千葉大学, 医学部・第一外科, 助手 1998: 千葉大学, 医学部第一外科, 助手 1996 – 1998: Chiba Univ.1st Dept of Surg.Assistan, 医学部, 助手 1995: 千葉大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Digestive surgery / Digestive surgery Except Principal Investigator Digestive surgery / Digestive surgery
Keywords	Principal Investigator Oxidative Stress / Carcinogenesis / Hepatocellular Carcinoma / 酸化ストレス / 発癌 / 肝細胞癌 / DNA Repair Genes / DNA Damage / Active Oxygen Species / Intrahepatic Recurrence … More / DNA傷害修復機構 / DNA傷害 / 活性酸素 / 肝内再発 / 発癌環境 / Multicentric Occurrence / Cyclooxygenase-2 / Cytochrome P450 / 多中心性肝細胞癌 / cyclooxygenase-2 / チトクロームP450 / chemokine / chemotaxis / neutrophil migration / hepatic failure / obstructive jaundice / 好中球浸潤 / ケモカイン / ケモタキシス / 好中球遊走 / 肝障害 / 閉塞性黄疸 … More Except Principal Investigator 遺伝子導入 / mTOR / Angiopoietin / VEGF / MHC antigen / 肝切除 / hepatectomy / Ito cell / sinusoidal endothelial cell / liver regeneration / 伊東細胞 / 類洞内皮細胞 / 肝再生 / patient selection / protein chip / gemcitabine / pancreatic cancer / 化学療法 / Annexin II / 薬剤耐性因子 / Gemcitabine / テーラーメード / プロテインチップ / Gemcitabone / 膵癌 / lymphangiogenesis / rapamycin / gene transfer / angiogenesis / chondromodulin-I / リンパ管新生 / ラパマイシン / 血管新生 / コンドロモジュリン-I / Sinusoidal endothelial cell / Angiogeneic factor / Acute rejection / Ribozyme / 急性拒絶反応 / 類洞壁細胞 / 血管増殖因子 / 酸化ストレス / MHC抗原 / リボザイム法 / graft rejection / electroporation / immunotherapy / gene transfection / major histocompatibility complex antigen / 移植片拒絶反応 / エレクトロポレーション / 腫瘍免疫療法 / 主要組織適合性抗原 / Cell proliferation / Somatostatin receptor / Somatostatin / Biliary tract tumor / Biliary tract carcinoma / 細胞増殖抑制 / 胆道癌 / 肝臓癌 / 細胞増殖 / ソマトスタチン受容体 / ソマトスタチン / 胆道癌 / 胆道腫瘍 / Endotoxin / Microcirculation / Obstructive jaundice / Hepatic dysfunction / エンドキシン / エンドトキシン / 微小循環 / 閉塞性黄胆 / 肝障害 / Antisense DNA / Gene transfection / Hepatic Sinusoidal endo thelial cell / Livertransplantation / アンチセンス / 細織適合性抗原 / アンチセンスDNA / 組織適合性抗原 / 肝類洞内皮細胞 / 肝移植 / Obstructive jaunfice / Inflammatory cytokine / Neutrophil / Hepatic failure / Hepatic resection / 活性化好中球 / 閉塞性黄疸 / 炎症性サイトカイン / 好中球 / 肝不全 Less

Mechanism of sinusoidal endothelial cell proliferation and maturation during hepatic regeneration
- Principal Investigator
  
  SHIMIZU Hiroaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Inhibition of tumor angiogenesis through chondromodulin-I gene transfer
- Principal Investigator
  
  OHTSUKA Masayuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Identification of factors involving chemotherapy resistance in pancreatic cancer patients by Protein Chip system for developing prediction system of chemotherapy response.
- Principal Investigator
  
  AMBIRU Satoshi, 外川明
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Evaluation of Underlying Hepatic Status in Hepatocellular Carcinoma Recurrence by Oxidative Stress Markers for DNA DamagePrincipal Investigator
- Principal Investigator
  
  ITO Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Modification of donor MHC antigens with ribozyme RNA transfer to prevent rejection of graft liver
- Principal Investigator
  
  SHIMIZU Hiroaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  CHIBA UNIVERSITY
Cytochrome P450 and Cyclooxygenease-2 expression in liver tissue surrounding hepatocellur carcinoma : Evaluation of environmental state of multicentric hepatocarcinogenesisPrincipal Investigator
- Principal Investigator
  
  ITO Hiroshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  CHIBA UNIVERSITY
The role of chemokines in neutrophils migration toward liver tissue in obstructive jaundice.Principal Investigator
- Principal Investigator
  
  ITO Hiroshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Expression of Somatostatin-Receptor and Inhibitory Effect of Somatostatin on Cell Proliferation in Hepatobiliary Malignancies
- Principal Investigator
  
  MIYAZAKI Masaru
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Regression of established murine adenocarcinoma by in vivo allogeneic MHC gene transfer using electroporation and modification of donor MHC antigens by antisense gene transfer to prevent rejection of transplanted organs
- Principal Investigator
  
  SHIMIZU Hiroaki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Roles of cells in the liver in occurrence of liver dysfunction in vivo
- Principal Investigator
  
  NAKAGAWA Koji
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Hepatic endothelial cell function in the assessment of graft viability after liver transplantation and modification of donor MHC antigens by antisense gene transfer to prevent rejection of transplanted organs
- Principal Investigator
  
  SHIMIZU Hiroaki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Mechanisns of Post-operatire Hepatic Failure after Extended Hepatectomy
- Principal Investigator
  
  MIYAZAKI Masaru, 宮崎勝
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University

All 2006 2005 2004 2003 Other

All Journal Article

[Journal Article] Changes in growth factor and cytokine expression in biliary obstructed rat liver and their relationship with delayed liver regeneration after partial hepatectomy.2006
- Author(s)
  Makino H, Shimizu H, Ito H, Kimura F, Yoshidome H, Ohtsuka M, Kato M, Yoshitomi H, Sawada S, Miyazaki M.
- Journal Title
  
  World Journal of Gastroenterology 7
  
  Pages: 2053-2059
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591375
[Journal Article] Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats.2005
- Author(s)
  Shimizu H, Mitsuhashi N, Ohtsuka M, Ito H, Kimura F, Ambiru F, Togawa A, Yoshidome H, Kato A, Miyazaki M.
- Journal Title
  
  World Journal of Gastroenterology 12
  
  Pages: 7254-7260
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591375
[Journal Article] Decreased cell-mediated immune status in colorectal cancer patients with hepatic metastasis.2005
- Author(s)
  Shimizu H, Ito H, Kimura F, Togawa A, Yoshidome H, Ohtsuka M, Kato A, Nukui Y, Miyazaki M.
- Journal Title
  
  Hepato-Gastroenterology 52
  
  Pages: 1106-1109
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591375
[Journal Article] Extended cold preservation of the graft liver enhances neutrophil-mediated pulmonary injury after liver transplantation2005
- Author(s)
  Shimizu H, Kataoka M, Ohtsuka M, Ito H, Kimura F, Togawa A, Yoshidome H, Kato A, Miyazaki M.
- Journal Title
  
  Hepato-Gastroenterology 52
  
  Pages: 1172-1175
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591375
[Journal Article] Should the inferior vena cava be reconstructed after resection for malignant tumors?2005
- Author(s)
  Yoshidome H, Taleicjo D, Ito H, Kimura F, Shimizu H, Ambiru S, Togawa A, Ohtsuka M, Kato A, Miyazaki M
- Journal Title
  
  Am J Surg. 189
  
  Pages: 419-424
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591296
[Journal Article] Circulating heat-shock protein 70 is associated with postoperative infection and organ dysfunction after liver resection.2004
- Author(s)
  Kimura F, Ito H.Ambiru S, Shimizu H, Togawa A, Yoshidome H, Ohtsuka M, Shimamura F, Kato A, Nukui Y, Miyazaki M
- Journal Title
  
  American Journal of Surgery 187
  
  Pages: 777-784
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591379
[Journal Article] Interleukin 18 causes hepatic ischemia/reperfusion injury by suppressing anti-inflammatory cytokine expression in mice.2004
- Author(s)
  Takeuchi D, Yoshidome H, Kato A, Ito H, Kimura F, Shimizu H, Ohtsuka M, Morita Y, Miyazaki M
- Journal Title
  
  Hepatology 39
  
  Pages: 699-710
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591379
[Journal Article] Should the extrahepatic bile duct be resected for locally advanced gallbladder cancer?2004
- Author(s)
  Shimizu Y, Ohtsuka M, Ito H, Kimura F, Shimizu H, Togawa A, Yoshidome H, Kato A, Miyazaki M.
- Journal Title
  
  Surgery 136
  
  Pages: 1012-1017
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591295
[Journal Article] Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma.2003
- Author(s)
  Mitsuhashi N, Shimizu H, Ohtsuka M, Wakabayashi Y, Ito H, Kimura F, Yoshidome H, Kato
- Journal Title
  
  Hepatology 37
  
  Pages: 1105-1113
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591379
[Journal Article] Extended hepatic resection and outcomes in intrahepatic chlangiocarcinoma.2003
- Author(s)
  Ohtsuka M, Ito H, Kimura F, Shimizu H, Togawa A, Yoshidome, H, Shimizu Y, Shimamura F, Miyazaki M
- Journal Title
  
  Journal of Hepato-biliary Pancreatic Surgery 10
  
  Pages: 259-264
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591379
[Journal Article] Relationship between pancreatic secretory trypsin inhibitor and early recurrence of intrahepatic cholangiocarcinoma following surgical resection.
- Author(s)
  Tonouchi A, Ohtsuka M, Ito H, Kimura F, Shimizu H, Kato M, Nimura Y, Iwase K, Hiwasa T, Seki N, Takiguchi M, Miyazaki M.
- Journal Title
  
  Am J Gastroenterol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591295
[Journal Article] Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats.
- Author(s)
  Shimizu H, Mitsuhashi N, Ohtsuka M, Ito H, Kimura F, Ambiru S, Togawa A, Yoshidome H, Kato A, Miyazaki M.
- Journal Title
  
  World J Gastroenterol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591295
[Journal Article] Identification of Apolipoporotein C-1 as a novel prognostic serum marker of pancreatic cancer by protein profiling and its role in cancer cell proliferation
- Author(s)
  Togawa A, Takano S, Yoshitomi H, Sogawa K, Shida T, Kimura F, Shimizu H, Tomonaga T, Nomura F, Miyazaki M
- Journal Title
  
  Gastroenterology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591296
[Journal Article] Aggressive surgical approach for Stage IV gallbladder carcinoma based on Japanese Society of Biliary Surgery Classification.
- Author(s)
  Shimizu H, Kimura F, Yoshidome H, Ohtsuka M, Kato A, Yoshitomi H, Nozawa S, Furukawa K, Mitsuhashi M, Takeuchi D, Suda K, Miyazaki M.
- Journal Title
  
  Journal of Hepatobiliary-Pancreatic Surgery (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591375

1. MIYAZAKI Masaru (70166156)

# of Collaborated Projects: 12 results

# of Collaborated Products: 13 results
2. AMBIRU Satoshi (30251200)

# of Collaborated Projects: 8 results

# of Collaborated Products: 2 results
3. OHTSUKA Masayuki (90334185)

# of Collaborated Projects: 7 results

# of Collaborated Products: 13 results
4. SHIMIZU Hiroaki (80272318)

# of Collaborated Projects: 6 results

# of Collaborated Products: 8 results
5. NAKAGAWA Kougi (10282477)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. YOSHIDOME Hiroyuki (10312935)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. ISHIKURA Hiroshi (70222982)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. YOSHITOMI Hideyuki (60375631)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. SEINO Susumu (80236067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KATO Atsushi (70344984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. KUROSAWA Hisashi (10375678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NOMURA Fumio (80164739)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 宮崎勝 (40239380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 外川明 (80334192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. SIMIZU Yoshiaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 貫井裕次

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ITO Hiroshi 伊藤 博

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Evaluation of Underlying Hepatic Status in Hepatocellular Carcinoma Recurrence by Oxidative Stress Markers for DNA DamagePrincipal Investigator

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Cytochrome P450 and Cyclooxygenease-2 expression in liver tissue surrounding hepatocellur carcinoma : Evaluation of environmental state of multicentric hepatocarcinogenesisPrincipal Investigator

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The role of chemokines in neutrophils migration toward liver tissue in obstructive jaundice.Principal Investigator

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[Journal Article] Changes in growth factor and cytokine expression in biliary obstructed rat liver and their relationship with delayed liver regeneration after partial hepatectomy.2006

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[Journal Article] Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats.2005

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[Journal Article] Decreased cell-mediated immune status in colorectal cancer patients with hepatic metastasis.2005

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ITO Hiroshi 伊藤博