HARA Junichi 原純一

Researcher Number	00238156
Affiliation *help	2013 : 大阪市立総合医療センター, 小児医療センター, 副院長 2005 : 地方独立行政法人大阪市民病院機構大阪市立総合医療センター（臨床研究センター）, 臨床研究センター, 副院長 2002 – 2004 : 大阪大学, 医学系研究科, 助教授 2002 – 2004 : 大阪大学, 医学部, 助教授 2003 : 大阪大学, 医学系研究科, 助手 … More
Review Section/Research Field	Principal Investigator Pediatrics / Pediatrics / Hematology Except Principal Investigator Pediatrics / Pediatric surgery / Pediatric surgery / Laboratory animal science / Biological Sciences
Keywords	Principal Investigator IL-8 / LRRC8 / MCL-1 / CD34+ CD38- / 白血病 / 肝細胞増殖因子 / hematopoietic stem cell / DNAマイクロアレイ / B細胞の分化 / MONO-7 … More Except Principal Investigator Rhabdomyosarcoma / 胞巣型 / 胎児型 / 造血幹細胞 / clinical trial / ポリコーム遺伝子群 / 臨床試験 / VAC / peripheral blood stem cell / 中央病理診断 / 小児がん / PAX3-FKHR / 横紋筋肉腫 / PAX7-FKHR / 外科治療 / 予後因子 / canser stem cell / 自己複製 / B前駆細胞型急性リンパ性白血病 / Familial Hemophagocytic lymphohistiocytosis / 放射線治療 / JRSG / 伝染性単核球症 / 治療法 / iPS / 維持 / children / 横紋筋肉 / 遺伝子発現維持 / rae28 / 血球貧食症候群 / 拡張型心筋症 / rhabdomyosarcoma / rae2 / EBウイルスゲノム / cancer stem cell / 顆粒リンパ増多症 / miR-206 / グループスタディ / PAX7 / 末梢リンパ球サブニユット / PAX3 / 未分化造血細胞 / 心臓 / 染色体高次構造 / VOD / リスク分類 / microRNA / ips / NOD / 慢性活動性EBウイルス感染症 / 心臓発生 / 発生 / 遺伝子発現維持機構 / SCID / ノックアウトマウス / SP細胞 / PAX3,7/FKHR Less

Development of the treatment strategy for childhood refractory sarcoma trying to use iPS technology for possible reprogramming of cancer stem cell.
- Principal Investigator
  
  MORIKAWA YASUHIDE
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatric surgery
- Research Institution
  Keio University
Functional characterization of LRRC8, a novel gene isolated from a patients with agammaglobulinemia, and its homologues.Principal Investigator
- Principal Investigator
  
  HARA Junichi, 松田佳子
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
The development of the new clinical trial based on the quality assurance of treatment process in the childhood rhabdomyosarcoma.
- Principal Investigator
  
  MORIKAWA Yasuhide
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatric surgery
- Research Institution
  Keio University
Detection and characterization of leukemic stem cellsPrincipal Investigator
- Principal Investigator
  
  HARA Junichi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
ポリコーム遺伝子群による染色高次体構造を介した転写制御と白血病
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
ポリコーム遺伝子群欠損マウスを用いた心臓発生維持と造血幹細胞の制御機構の研究
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
  Osaka University
SCIDマウスを用いた血球貧食症候群モデルの作製とそれを用いた病態の解明
- Principal Investigator
  
  谷池雅子
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
白血病細胞に対する多機能サイトがVHGFの分化・増殖作用の検討Principal Investigator
- Principal Investigator
  
  原純一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
ダウン症児におけるTAMと急性巨核芽球性白血病の生物学的差異の比較検討Principal Investigator
- Principal Investigator
  
  原純一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University
慢性活動性EBウイルス感染症の病因・病態の解明と治療法の開発
- Principal Investigator
  
  多和昭雄
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka University

All 2014 2013 2012 2011 2004 2003 2002 Other

All Journal Article Presentation

[Journal Article] Increased expression of survivin in hepatoblastoma after chemotherapy2014
- Author(s)
  Ｉehara S, Oue T, Kawatsu M, Nara K, Fukuzawa M
- Journal Title
  
  European Journal of Pediatric Surgery
  
  Volume : 46 Pages : 326-331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23256006, KAKENHI-PROJECT-21249085, KAKENHI-PROJECT-23592629, KAKENHI-PROJECT-23592630
[Journal Article] 頬部横紋筋肉腫に対する集学的治療後4年で発生した耳下腺悪性腫瘍の1例2013
- Author(s)
  上原秀一郎, 太田秀明, 山本佳史, 橋井佳子, 大植孝治,福澤正洋
- Journal Title
  
  日本小児血液・がん学会雑誌
  
  Volume : 50 Pages : 232-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249085
[Journal Article] 頬部横紋筋肉腫に対する集学的治療後4年で発生した耳下腺悪性腫瘍の1例.2013
- Author(s)
  上原秀一郎、太田秀明、山本佳史、橋井佳子、大植孝治、福澤正洋
- Journal Title
  
  日本小児血液・がん学会雑誌
  
  Volume : 50 Pages : 232-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249085
[Journal Article] Increased expression of survivin in hepatoblastoma after chemotherapy2013
- Author(s)
  Shuichiro Uehara, Takaharu Oue, Miyoko Kawatsu, Keigo Nara, Masahiro Fukuzawa
- Journal Title
  
  European Journal of Pediatric Surgery
  
  Volume : Feb.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249085
[Journal Article] Effect of an omega-3 lipid emulsion in reducing oxidative stress in a rat model of intestinal ischemia-reperfusion injury.2012
- Author(s)
  Arisue A, Shimojima N, Tomiya M, Shimizu T, Harada D, Nakayama M, Tomita H, Shinoda M, Tanabe M, Maruyama I, Mizuno M, Kuroda T, Wakabayashi G, Morikawa Y.
- Journal Title
  
  Pediatr Surg Int.
  
  Volume : 28 Pages : 913-918
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249085, KAKENHI-PROJECT-23591875, KAKENHI-PROJECT-24591888
[Journal Article] Second allogeneic hematopoietic stem cell transplantation for relapsed acute lymphoblastic leukemia in children2012
- Author(s)
  3. Kato M, Horikoshi Y, Okamoto Y, YTakahashi Y, Hasegawa D, Koh K, Takita J, Inoue M, Kigasawa H, Ogawa A, Sasahara Y, Kawa K, Yabe H, Sakamaki H, Suzuki R, Kato K.
- Journal Title
  
  Bone Marrow Transplantat
  
  Volume : 47 Pages : 1307-1311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249085, KAKENHI-PROJECT-21591239, KAKENHI-PROJECT-23390269, KAKENHI-PROJECT-23591530, KAKENHI-PROJECT-24659491
[Journal Article] The utility of performing the initial lumbar puncture on d ay 8 in remission induction therapy for childhood acute lymphoblastic leukem ia：TCCSG L99-15 study2012
- Author(s)
  D. Hasegawa, A. Manabe, A. Ohara, A. Kikuchi, K. Koh, N. Kiyokawa, T. Fuk ushima,Y. Ishida, T. Saito, R. Hanada, M. Tsuchida, The Tokyo Children's Can cer Study Group
- Journal Title
  
  Pediatr Blood Cancer
  
  Volume : 58 Pages : 23-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249085
[Journal Article] LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.2004
- Author(s)
  Kubota K, Hara J et al.
- Journal Title
  
  FEBS Lett. 23;564(1-2)
  
  Pages : 147-152
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207071
[Journal Article] Defective long-term repopulating ability in hematopoietic stem cells lacking the Polycomb-group gene rae28.2004
- Author(s)
  Kim, J.Y.Sawada, A.Tokimasa, S.Endo, H.Ozono, K.Hara, J.Takihara, Y.
- Journal Title
  
  Eur J Haematol 73
  
  Pages : 75-84
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570743
[Journal Article] LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins2004
- Author(s)
  Kubota K, Kim JY, Sawada A, Tokimasa S, Fujisaki H, Matsuda-Hashii Y, Ozano K, Hara J.
- Journal Title
  
  FEBS Letters 564(1-2)
  
  Pages : 147-152
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591105
[Journal Article] Fenretinide induces sustained-activation of JNK/p38 MAPK and apoptosis ina reactive oxygen species-dependent manner in nueroblastoma cells.2004
- Author(s)
  Osono S, Hosoi H, Kuwahara Y et al.
- Journal Title
  
  Int J Cancer 112(2)
  
  Pages : 219-224
- Data Source
  KAKENHI-PROJECT-14207071
[Journal Article] Hepatocyte growth factor plays roles in the induction and autocrine maintenance of bone marrow stromal cell IL-11, SDF-1 alpha and stem cell factor.2004
- Author(s)
  Matsuda-Hashii Y, Takai K, Hara J et al.
- Journal Title
  
  Exp Hematol 32(10)
  
  Pages : 955-961
- Data Source
  KAKENHI-PROJECT-14207071
[Journal Article] LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins2004
- Author(s)
  Keiko K, Matsuda-Hashii Y, Hara J, et al.
- Journal Title
  
  FEBS Letters 564(1-2)
  
  Pages : 147-152
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591105
[Journal Article] Defective long-term repopulating ability in hematopoietic stem cells lacking the Polycomb-group gene rae28.2004
- Author(s)
  Kim, J.Y., Sawada, A., Tokimasa, S., Endo, H., Ozono, K., Hara, J., Takihara, Y.
- Journal Title
  
  Eur J Haematol 73
  
  Pages : 75-84
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570743
[Journal Article] 横紋筋肉腫に対する治療プロトコール化学療法レジメンと放射線治療および外科治療ガイドライン2004
- Author(s)
  森川康英, 土田嘉昭, 原純一, 太田茂, 細井創, 池田均ほか
- Journal Title
  
  小児外科 36(7)
  
  Pages : 939-946
- Data Source
  KAKENHI-PROJECT-14207071
[Journal Article] Antitumor activity of gefitinib in malignant rhabdoid tumor cells in vitro and in vivo2004
- Author(s)
  Kuwahara Y, Hosoi H, Osone S et al.
- Journal Title
  
  Clin Cancer Res 10(17)
  
  Pages : 5940-5948
- Data Source
  KAKENHI-PROJECT-14207071
[Journal Article] A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans2003
- Author(s)
  Sawada A, Takihara Y, Kim JY, Matsuda-Hashii Y, Tokimasa S, Fujisaki H, Kubota K, Endo H, Onodera T, Ohta H, Ozono K, Hara J.
- Journal Title
  
  J Clin Incest. 112(11)
  
  Pages : 1707-1713
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591105
[Journal Article] A congenital mutation of the novel gene LRRC8 causes agammaglobuloinemia in humans2003
- Author(s)
  Sawada A, Matsuda-Hashii Y, Hara J, et al.
- Journal Title
  
  J Clin Incest 112(11)
  
  Pages : 1707-1713
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591105
[Journal Article] Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells.2002
- Author(s)
  Ohta, H.Sawada, A.Kim, J.Y.Tokimasa, S.Nishiguchi, S.Humphries, R.K.Hara, J.Takihara, Y.
- Journal Title
  
  J Exp Med 195
  
  Pages : 759-770
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570743
[Journal Article] Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells.2002
- Author(s)
  Ohta, H., Sawada, A., Kim, J.Y., Tokimasa, S., Nishiguchi, S., Humphries, R.K., Hara, J., Takihara Y.
- Journal Title
  
  J Exp Med 195
  
  Pages : 759-770
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570743
[Journal Article] Establishment of a monosomy 7 leukemia cell line, MONO-7, with a ras gene mutation.2002
- Author(s)
  Fujisaki, H., Takai, K., Akihisa, S., Tokimasa, S., Matsuda, Y., Ohta, H., Osugi, Y., Kim, J.Y., Sako, M., Hara, J.
- Journal Title
  
  Int J Hematol 75
  
  Pages : 72-77
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570743
[Journal Article] Establishment of a monosomy 7 leukemia cell line, MONO-7, with a ras gene mutation.2002
- Author(s)
  Fujisaki H, Takai, K.Akihisa, S.Tokimasa, S.Matsuda, Y.Ohta, H Osugi, Y.Kim, J.Sako M.Hara, J.
- Journal Title
  
  Int J Hematol 75
  
  Pages : 72-77
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570743
[Presentation] 新規ALK結合蛋白質であるFlotillin-1は、endocytosisを介してALKシグナルを制御する2013
- Author(s)
  富山新太，上北尚正，山口英樹，佐々木一樹，滝田順子，中川原章，森健太郎，堺隆一
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Data Source
  KAKENHI-PROJECT-21249085
[Presentation] 神経芽腫におけるALK発現と国際神経芽腫病理分類との関連2012
- Author(s)
  中澤温子，大喜多肇，田中祐吉，中川原章，滝田順子，家原知子，田尻達郎，池田均，秦順一
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌、札幌市教育文化会館、他(北海道）
- Data Source
  KAKENHI-PROJECT-21249085
[Presentation] VALIDATION OF SERUM MIR-206 EXPRESSION LEVEL AS A DIAGNOSTIC BIOMARKER FOR RHABDOMYOSARCOMA:A REPOT OF THE CHILDREN’S ONCOLOGY GROUP STUDY ARST12B12012
- Author(s)
  Miyachi M，Tsuchiya K，Yagyu S，Iehara T，Stephen X Skapek，Douglas S Hawkins，Hosoi H
- Organizer
  44th Congress of the International Society of Pediatric Oncology
- Place of Presentation
  ロンドン（イギリス）
- Data Source
  KAKENHI-PROJECT-21249085
[Presentation] 神経幹細胞を用いたマウス脳腫瘍モデルにおける活性化型ALK誘導発がんメカニズム2012
- Author(s)
  大西伸幸，サンぺトラオルデア，杉原英志，清水孝恒，滝田順子，小川誠司，佐谷秀行
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌、札幌市教育文化会館、他(北海道）
- Data Source
  KAKENHI-PROJECT-21249085
[Presentation] 小児がん診療における専門医療機関相互の連携：その役割と課題2012
- Author(s)
  鈴木　涼子、福島　敬、福島　紘子、小林　千恵、水本　斉志、櫻井　英幸、小室　広昭、山本　哲哉、中川原　章、須磨崎　亮
- Organizer
  第115回日本小児科学会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-21249085
[Presentation] 神経幹細胞を用いたマウス脳腫瘍モデルの構築2011
- Author(s)
  大西伸幸, サンペトラオルデア, 杉原英志, 滝田順子, 他
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知)
- Data Source
  KAKENHI-PROJECT-21249085
[Presentation] 当院における横紋筋肉腫22症例の臨床病理学的検討特に再発・転移症例と大量化学療法について2011
- Author(s)
  上原秀一郎, 福澤正洋, 他
- Organizer
  第48回日本小児外科学会学術集会
- Place of Presentation
  TFT東京ファッションタウンビル(東京)
- Data Source
  KAKENHI-PROJECT-21249085
[Presentation] 難治性小児悪性腫瘍の遠隔転移（肺・肝転移）に対する外科治療の意義.
- Author(s)
  大植孝治、上原秀一郎、上野豪久、米田光宏、福澤正洋、吉田寿雄、橋井佳子
- Organizer
  日本外科学会定期学術集会(113)
- Place of Presentation
  福岡国際会議場（福岡）
- Data Source
  KAKENHI-PROJECT-21249085
[Presentation] High serum miR-206 expression levels define an aggressive rhabdomyosarcoma subtype
- Author(s)
  Miyachi M, Tsuchiya K, Yagyu S, Iehara T, Hosoi H
- Organizer
  第71回日本癌学会学術集会
- Place of Presentation
  札幌教育文化会館（北海道）
- Data Source
  KAKENHI-PROJECT-21249085

1. MATSUDA Yoshiko (60343258)

# of Collaborated Projects : 3results

# of Collaborated Products : 6results
2. MORIKAWA YASUHIDE (90124958)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
3. HOSHINO Ken (70190197)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
4. OHTA Shigeru (40127014)

# of Collaborated Projects : 2results

# of Collaborated Products : 4results
5. HOSOI Hajime (20238744)

# of Collaborated Projects : 2results

# of Collaborated Products : 5results
6. OHTA Hideaki (60322187)

# of Collaborated Projects : 2results

# of Collaborated Products : 1results
7. 大杉夕子 (40273669)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
8. 瀧原義宏 (60226967)

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# of Collaborated Products : 0results
9. 多和昭雄 (00155277)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
10. FUJISAKI Hiroyuki

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
11. KURODA Tatsuo (60170130)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
12. FUCHIMOTO Yasushi (40219077)

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13. IKEDA Hitoshi (10326928)

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# of Collaborated Products : 1results
14. FUKUSHIMA Takashi (30323299)

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15. NIO Masaki (70228138)

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16. FUKUZAWA Masahiro (60165272)

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# of Collaborated Products : 6results
17. TAKITA Junko (00359621)

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# of Collaborated Products : 5results
18. KANEKO Michio (60152807)

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19. KUSAFUKA Takeshi (70263267)

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20. MAKIMOTO Atsushi (70505916)

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21. HOJO Hiroshi (90209213)

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22. OKITA Hajime (50317260)

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23. NAKAZAWA Atsuko (90227736)

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# of Collaborated Products : 3results
24. TAKIMOTO Tetsuya (40393178)

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25. KUBOTA Tetsuro (00118944)

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26. 谷池雅子 (30263289)

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27. 石原重彦 (70232329)

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28. 三好淳 (80166214)

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29. 瀧原圭子 (70252640)

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30. 岡本三紀 (20332455)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
31. 西口聖治 (90237686)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
32. MASAKI Eiichi

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
33. 時政定雄

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
34. OUE Takaharu

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
35. UEHARA Shuichiro

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

HARA Junichi 原 純一

Research Projects

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Development of the treatment strategy for childhood refractory sarcoma trying to use iPS technology for possible reprogramming of cancer stem cell.

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Functional characterization of LRRC8, a novel gene isolated from a patients with agammaglobulinemia, and its homologues.Principal Investigator

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The development of the new clinical trial based on the quality assurance of treatment process in the childhood rhabdomyosarcoma.

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Detection and characterization of leukemic stem cellsPrincipal Investigator

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ポリコーム遺伝子群による染色高次体構造を介した転写制御と白血病

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ポリコーム遺伝子群欠損マウスを用いた心臓発生維持と造血幹細胞の制御機構の研究

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SCIDマウスを用いた血球貧食症候群モデルの作製とそれを用いた病態の解明

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白血病細胞に対する多機能サイトがVHGFの分化・増殖作用の検討Principal Investigator

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ダウン症児におけるTAMと急性巨核芽球性白血病の生物学的差異の比較検討Principal Investigator

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慢性活動性EBウイルス感染症の病因・病態の解明と治療法の開発

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[Journal Article] Increased expression of survivin in hepatoblastoma after chemotherapy2014

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[Journal Article] 頬部横紋筋肉腫に対する集学的治療後4年で発生した耳下腺悪性腫瘍の1例2013

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[Journal Article] 頬部横紋筋肉腫に対する集学的治療後4年で発生した耳下腺悪性腫瘍の1例.2013

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[Journal Article] Increased expression of survivin in hepatoblastoma after chemotherapy2013

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HARA Junichi 原純一

[Journal Article] 横紋筋肉腫に対する治療プロトコール化学療法レジメンと放射線治療および外科治療ガイドライン2004