YAMADA Hiriyuki 山田浩之

Researcher Number	00240036
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2021: 京都府立医科大学, 医学(系)研究科(研究院), 准教授 2016 – 2018: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2012 – 2015: 京都府立医科大学, 医学(系)研究科(研究院), 助教 2006 – 2011: Kyoto Prefectural University of Medicine, Graduate School of Medicine, Assistant Professor, 医学研究科, 助教 2005: 京都府立医科大学, 医学部, 博士研究員 2004: 京都府立医大, 医学系研, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Basic Section 53020:Cardiology-related / Cardiovascular medicine
Keywords	Principal Investigator 動脈硬化 / 好中球細胞外トラップ / うつ病 / 炎症 / マクロファージ / 胎児プログラミング / 受容体 / アンジオテンシン / 血管病態学 / CHIP … More / 腹部大動脈瘤 / エピジェネティクス / 母体高脂肪食 / 血小板 / 細胞外トラップ形成 / 血栓 / 鬱病 / 血栓形成 / 心血管病 / 好中球 / receptors / progenitors / bone marrow cells / atherosclerosis / angiotensin II / 前駆細胞 / 骨髄細胞 / アンジオテンシンII / 肥満 / 脂肪細胞 / 血管周囲脂肪 / 脂肪酸結合蛋白 / 脂肪酸代謝 / レニン・アンジオテンシン系 / 脂肪組織 / 慢性腎臓病 / 骨髄単球系幹細胞 Less

Precision medicine for cardiovascular diseases by targeting clonal hematopoiesis of indeterminate potential via fetal programmingPrincipal Investigator
- Principal Investigator
  
  山田浩之
- Project Period (FY)
  2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Novel therapeutic strategy for arterial thrombosis by targeting neutrophil extracellular trap formation in socially defeated micePrincipal Investigator
- Principal Investigator
  
  Yamada Hiroyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Novel therapeutic strategy for atherosclerosis by regulating myeloid lineage cells in socially defeated micePrincipal Investigator
- Principal Investigator
  
  Yamada Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kyoto Prefectural University of Medicine
A novel therapeutic strategy for atherosclerotic diseases by regulating developmental gene expression in perivascular adipose tissuePrincipal Investigator
- Principal Investigator
  
  YAMADA Hiroyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Identification of a novel gene to promote atherosclerosis development by regulating fatty acid binding protein secreted from dysfunctional kidneyPrincipal Investigator
- Principal Investigator
  
  YAMADA Hiroyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Role of T lymphocyte activation by angiotensin II in the development of vulnerable plaquePrincipal Investigator
- Principal Investigator
  
  YAMADA Hiriyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Analysis of the mechanisms for antiatherogenic effect of bone marrow AT2 receptor by using gene-targeted micePrincipal Investigator
- Principal Investigator
  
  YAMADA Hiroyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
発生工学を用いたアンジオテンシンAT2受容体の樹状細胞分化と抗動脈硬化作用の解析Principal Investigator
- Principal Investigator
  
  山田浩之
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto Prefectural University of Medicine

[Book] THE ARB2006
- Author(s)
  山田浩之, 高田博輝, 勝目あさ子, 椿本恵則, 横井宏和, 松原弘明
- Total Pages
  487
- Publisher
  ARBの薬理作用心臓リモデリング改善作用
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] Repeated Social Defeat Enhances CaCl2-Induced Abdominal Aortic Aneurysm Expansion by Inhibiting the Early Fibrotic Response via the MAPK-MKP-1 Pathway.2022
- Author(s)
  Kubota H, Yamada H, Sugimoto T, Wada N, Motoyama S, Saburi M, Miyawaki D, Wakana N, Kami D, Ogata T, Ibi M, Matoba S.
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 4 Pages: 732-732
- DOI
  10.3390/cells11040732
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08037, KAKENHI-PROJECT-19H03567, KAKENHI-PROJECT-20K07087
[Journal Article] Maternal High-Fat Diet Promotes Abdominal Aortic Aneurysm Expansion in Adult Offspring by Epigenetic Regulation of IRF8-Mediated Osteoclast-like Macrophage Differentiation.2021
- Author(s)
  Saburi M, Yamada H, Wada N, Motoyama S, Sugimoto T, Kubota H, Miyawaki D, Wakana N, Kami D, Ogata T, Matoba S.
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 9 Pages: 2224-2224
- DOI
  10.3390/cells10092224
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08037
[Journal Article] Adrenergic receptor-mediated activation of FGF-21-adiponectin axis exerts atheroprotective effects in brown adipose tissue-transplanted apoE-/- mice2018
- Author(s)
  Masakazu Kikai, Hiroyuki Yamada, Noriyuki Wakana, Kensuke Terada, Keita Yamamoto, Naotoshi Wada, Shinichiro Motoyama, Makoto Saburi, Takeshi Sugimoto, Daisuke Irie, Taku Kato, Hiroyuki Kawahito, Takehiro Ogata, Satoaki Matoba
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 497 Pages: 1097-1103
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09162
[Journal Article] Transplantation of periaortic adipose tissue inhibits atherosclerosis in apoE-/- mice by evoking TGF-β1-mediated anti-inflammatory response in transplanted graft.2018
- Author(s)
  Terada K, Yamada H, Kikai M, Wakana N, Yamamoto K, Wada N, Motoyama S, Saburi M, Sugimoto T, Irie D, Kato T, Kawahito H, Kami D, Ogata T, Matoba S.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 501 Issue: 1 Pages: 145-151
- DOI
  10.1016/j.bbrc.2018.04.196
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08081
[Journal Article] Augmented neutrophil extracellular traps formation promotes atherosclerosis development in socially defeated apoE-/- mice2018
- Author(s)
  Keita Yamamoto, Hiroyuki Yamada, Noriyuki Wakana, Masakazu Kikai, Kensuke Terada, Naotoshi Wada, Shinichiro Motoyama, Makoto Saburi, Takeshi Sugimoto, Daisuke Kami, Takehiro Ogata, Masakazu Ibi, Chihiro Yabe-Nishimura, Satoaki Matoba
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: xxx Pages: 1-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09162
[Journal Article] Loss of MURC/Cavin-4 induces JNK and MMP-9 activity enhancement in vascular smooth muscle cells and exacerbates abdominal aortic aneurysm2017
- Author(s)
  Kotaro Miyagawa, Takehiro Ogata, Tomomi Ueyama, Takeru Kasahara, Naohiko Nakanishi, Daisuke Naito, Takuya Taniguchi, Tetsuro Hamaoka, Naoki Maruyama, Masahiro Nishi, Taizo Kimura, Hiroyuki Yamada, Hiroki Aoki, Satoaki Matoba
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 487 Pages: 587-593
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09162
[Journal Article] Maternal High-Fat Diet Exaggerates Atherosclerosis in Adult Offspring by Augmenting Periaortic Adipose Tissue-Specific Proinflammatory Response2015
- Author(s)
  Noriyuki Wakana, Daisuke Irie, Masakazu Kikai, Kensuke Terada, Keita Yamamoto, Hiroyuki Kawahito, Taku Kato, Takehiro Ogata, Tomomi Ueyama, Satoaki Matoba, Hiroyuki Yamada
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 35 Issue: 3 Pages: 558-569
- DOI
  10.1161/atvbaha.114.305122
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591120
[Journal Article] Short-Term Treatment with an Angiotensin II Receptor Blocker Prevents Necrotic Core Formation by Inhibiting Oxidative Stress-Mediated Apoptosis in Macrophages.2015
- Author(s)
  Kishida S, Yamada H, Wakana N, Kawahito H, Irie D, Kato T, Kikai M, Terada K, Yamamoto K, Wada N, Motoyama S, Takata H, Yokoi H, Tsubakimoto Y, Ogata T, Ueyama T, Satoaki M.
- Journal Title
  
  Int J Cardiovasc Res
  
  Volume: ５ Issue: 01 Pages: 1-1
- DOI
  10.4172/2324-8602.1000252
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09162
[Journal Article] Dipeptidyl peptidase-4 inhibitor sitagliptin improves pancreatic β-cell function in hypertensive diabetic patients treated with angiotensin receptor blockers.2015
- Author(s)
  Fukui K, Kawahito H, Wakana N, Kikai M, Terada K, Yamamoto K, Irie D, Kato T, Miyagawa S, Yamada H.
- Journal Title
  
  J Renin Angiotensin Aldosterone Syst.
  
  Volume: １６ Issue: 4 Pages: 1001-1009
- DOI
  10.1177/1470320315587180
- Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09162
[Journal Article] Periaortic adipose tissue-specific activation of the renin-angiotensin system contributes to atherosclerosis development in uninephrectomized apoE-/- mice.2013
- Author(s)
  25. Kawahito H, Yamada H, Irie D, Kato T, Akakabe Y, Kishida S, Takata H, Wakana N, Ogata T, Ikeda K, Ueyama T, Matoba S, Mori Y, Matsubara H.
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 305 Issue: 5 Pages: 667-675
- DOI
  10.1152/ajpheart.00053.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591120
[Journal Article] CKDと心血管病2012
- Author(s)
  川人浩之, 山田浩之, 松原弘明
- Journal Title
  
  Renin Academy Japan Journal
  
  Volume: 9 Pages: 12-13
- Data Source
  KAKENHI-PROJECT-21590957
[Journal Article] Bone Marrow AT_1 Augments Neointima Formation by Promoting Mobilization of Smooth Muscle Progenitors via Platelet-Derived SDF-1α2010
- Author(s)
  Yokoi H, Yamada H, Tsubakimoto Y, Takata H, Kawahito H, Kishida S, Taku Kato T, Akihiro Matsui A, Hideyo Hirai H, Eishi Ashihara E, Taira Maekawa T, Masaru Iwai M, Masatsugu Horiuchi M, Kouji Ikeda K, Tomosaburo Takahashi T, Mitsuhiko Okigaki M, and Hiroaki Matsubara H
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 30 Pages: 60-67
- Data Source
  KAKENHI-PROJECT-21590957
[Journal Article] 高血圧における冠動脈疾患(CAD)の治療2010
- Author(s)
  山田浩之
- Journal Title
  
  高血圧診療ガイド
  
  Pages: 212-218
- Data Source
  KAKENHI-PROJECT-21590957
[Journal Article] Bone Marrow Angiotensin AT_1 Receptor Regulates Differentiation of Monocyte Lineage Progenitors from Hematopoietic Stem Cells2009
- Author(s)
  Tsubakimoto Y, Yamada H, Yokoi H, Kishida S, Takata H, Kawahito H, Matsui A, Urao N, Nozawa Y, Hirai H, Imanishi J, Ashihara E, Maekawa T, Takahashi T, Okigaki M, Hiroaki Matsubara H
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 29 Pages: 1529-1536
- Data Source
  KAKENHI-PROJECT-21590957
[Journal Article] 骨髄RASの血管傷害後内膜増生における役割2009
- Author(s)
  山田浩之, 松原弘明
- Journal Title
  
  医学のあゆみ
  
  Volume: 228(5) Pages: 446-451
- Data Source
  KAKENHI-PROJECT-21590957
[Journal Article] 受容体・シグナル伝達の最新知見AT1受容体高血圧(第4版)2009
- Author(s)
  山田浩之, 松原弘明
- Journal Title
  
  日本臨床社
  
  Pages: 288-293
- Data Source
  KAKENHI-PROJECT-21590957
[Journal Article] プラーク形成・不安定化におけるAT1受容体の役割2009
- Author(s)
  山田浩之, 横井宏和, 椿本恵則, 高田博樹, 川人浩之, 岸田聡, 松原弘明
- Journal Title
  
  分子血管病学
  
  Volume: 10(2) Pages: 25-31
- Data Source
  KAKENHI-PROJECT-21590957
[Journal Article] 骨髄RASの血管障害後内膜増生における役割2009
- Author(s)
  山田浩之, 松原弘明
- Journal Title
  
  医学のあゆみ 228
  
  Pages: 446-451
- Data Source
  KAKENHI-PROJECT-19590870
[Journal Article] 骨髄RASの血管傷害後内膜増生における役割2009
- Author(s)
  山田浩之、松原弘明
- Journal Title
  
  医学のあゆみ 228(5)
  
  Pages: 446-451
- Data Source
  KAKENHI-PROJECT-19590870
[Journal Article] 骨髄単級系細胞とRAS2008
- Author(s)
  椿本恵則, 山田浩之, 岸田聡, 川人浩之, 高田博樹, 松原弘明
- Journal Title
  
  Angiotensin Research 5
  
  Pages: 12-16
- Data Source
  KAKENHI-PROJECT-19590870
[Journal Article] 骨髄単球系細胞とRAS2008
- Author(s)
  椿本恵則、山田浩之、岸田聡、川人浩之、高田博樹、松原弘明
- Journal Title
  
  Angiotensin Research 5(4)
  
  Pages: 12-16
- Data Source
  KAKENHI-PROJECT-19590870
[Journal Article] 動脈硬化形成における骨髄RA系の役割2007
- Author(s)
  山田浩之
- Journal Title
  
  医学のあゆみ 223
  
  Pages: 1211-1216
- Data Source
  KAKENHI-PROJECT-19590870
[Journal Article] 動脈硬化形成における骨髄RA系の役割2007
- Author(s)
  山田浩之、椿本恵則、松原弘明
- Journal Title
  
  医学のあゆみ 223(13)
  
  Pages: 1211-1216
- Data Source
  KAKENHI-PROJECT-19590870
[Journal Article] 動脈硬化形成におけるRASの意義2006
- Author(s)
  松原弘明, 山田浩之, 椿本恵則, 横井宏和
- Journal Title
  
  日本内科学会雑誌 95 (9)
  
  Pages: 138-144
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] 動脈硬化形成におけるRASの意義2006
- Author(s)
  松原弘明, 山田浩之, 椿本恵則, 横井宏和
- Journal Title
  
  日本内科学会雑誌 95(9)
  
  Pages: 138-144
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] Erythropoietin-Mobilized Endothelia Progenitors Enhance Reendothelialization via Akt-Endothelial Nitric Oxide Synthase Activation and Prevent Neointimal Hyperplasia.2006
- Author(s)
  Urao N, Okigaki M, Yamada H, Adachi Y, Matsuno K, Matsui A, Matsunaga S, Tateishi K, Nomura T, Takahashi T, Tatsumi T, Matsubara H.
- Journal Title
  
  Cir Res 98
  
  Pages: 1405-1413
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] アンジオテンシン受容体の分類とその機能2006
- Author(s)
  山田浩之, 椿本恵則, 横井宏和, 松井朗裕
- Journal Title
  
  治療学 40(1)
  
  Pages: 21-25
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] Protective effects on vascular endothelium.2006
- Author(s)
  Yamada H, Matsui H, Tsubakimoto Y, Yokoi H, Matsubara H.
- Journal Title
  
  Hypertension 64
  
  Pages: 482-486
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] 血管内皮保護効果2006
- Author(s)
  山田浩之, 松井朗裕, 椿本恵則, 横井宏和, 松原弘明
- Journal Title
  
  高血圧(第3版) 64(Suppl5)
  
  Pages: 482-486
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] Pharmacological effect of ARB, Improvement of cardiac remodeling.2006
- Author(s)
  Yamada H, Takata H, Katsume A, Tsubakimoto Y, Yokoi H, Matsubara H.
- Journal Title
  
  THE ARB
  
  Pages: 283-289
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] Erythropoietin-mobilized endotherial progenitors enhance reendothelialization via Akt-endothelial nitric oxide synthase activation and prevent neointimal hyperplasia2006
- Author(s)
  Urao N, Okigaki M, Yamada H, et al.
- Journal Title
  
  Circulation Research 98
  
  Pages: 1405-1413
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] The significance of renin-angiotensin system in the development of atherosclerosis.2006
- Author(s)
  Matsubara H, Yamada H, Tsubakimoto Y, Yokoi H.
- Journal Title
  
  Internationl Medicine 95
  
  Pages: 138-144
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] Classification of angiotensin receptors and their function2006
- Author(s)
  Yamada H, Tsubakimoto Y, Yokoi H, Matsui Y, Matsubara H.
- Journal Title
  
  Biomedicine ＆ Therapeutics 40
  
  Pages: 21-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] アンジオテンシン受容体の分類とその機能2006
- Author(s)
  山田浩之, 椿本恵則, 横井宏和, 松井朗裕, 松原弘明
- Journal Title
  
  治療学 40(1)
  
  Pages: 21-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] 血管内皮保護効果2006
- Author(s)
  山田浩之, 松井朗裕, 椿本恵則, 横井宏和, 松原弘明
- Journal Title
  
  高血圧(第3版) 64 (5)
  
  Pages: 482-486
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] The proper use of ACE inhibitor and angiotensin receptor blockade2005
- Author(s)
  Yamada H, Tsubakimoto Y, Yokoi H, Urao N, Matsubara H.
- Journal Title
  
  Heart View 9
  
  Pages: 89-95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] Noxl Is Involved in Angiotensin II-Mediated Hypertension-A Study in Noxl-Deficient Mice.2005
- Author(s)
  Matsuno K, Yamada H, Iwata K, Jin D, Katsuyama M, Matsuki M, Takai S, Yamanishi K, Miyazaki M, Matsubara H, Yabe-Nishimura C.
- Journal Title
  
  Circulation 112
  
  Pages: 2677-2685
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] Nox1 is involved in angiotensin II-mediated hypertension : A study in Nox1-deficient mice2005
- Author(s)
  Matsuno K, Yamada H, et al.
- Journal Title
  
  Circulation 112
  
  Pages: 2677-2685
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] ACE阻害薬とARBの使い分け2005
- Author(s)
  山田浩之, 椿本恵則, 横井宏和, 浦尾紀文, 松原弘明
- Journal Title
  
  Heart View 9(8)
  
  Pages: 89-95
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] Renin-angiotensin system and angiogenesis.2005
- Author(s)
  Yamada H, Urao N, Takamiya M, Irie H, Matsubara H.
- Journal Title
  
  Clinical ＆ Molecular Endocrinology (2) 63
  
  Pages: 102-106
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Journal Article] レニン-アンジオテンシン系と血管新生2005
- Author(s)
  山田浩之, 浦尾紀文, 高宮充孝, 入江秀和, 松原弘明
- Journal Title
  
  臨床分子分泌学 (2) 63 (3)
  
  Pages: 102-106
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590760
[Presentation] Repeated social defeat exaggerates fibrin-rich clot formation in FeCl3-induced arterial thrombosis mice model by enhancing NETs formation.2021
- Author(s)
  Sugimoto T, Yamada H, et al.
- Organizer
  第85回日本循環器学会
- Data Source
  KAKENHI-PROJECT-18K08081
[Presentation] Repeated social defeat exaggerates fibrin-rich clot formation by enhancing NETs formation via platelet-neutrophil interactions2020
- Author(s)
  Sugimoto T, Yamada H, et al.
- Organizer
  American Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08081
[Presentation] Repeated social defeat exaggerates fibrin-rich clot formation in FeCl3-induced arterial thrombosis mouse model by enhancing NETs formation via modulation of neutrophil functional properties2020
- Author(s)
  Sugimoto T, Yamada H, et al.
- Organizer
  European Society of Cardiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08081
[Presentation] Repeated social defeat exaggerates fibrin-rich clot formation in FeCl3-induced arterial thrombosis mice model by enhancing NETs formation.2019
- Author(s)
  Sugimoto T, Yamada H, Kubota H, Miyawaki D, Motoyama S, Wada N, Saburi M, Wakana N, Matoba S.
- Organizer
  欧州心臓病学術会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08081
[Presentation] Repeated social defeat exaggerates fibrin-rich clot formation in FeCl3-induced arterial thrombosis mice model by enhancing NETs formation.2019
- Author(s)
  Sugimoto T, Yamada H, Kubota H, Miyawaki D, Saburi M, Wakana N, Matoba S.
- Organizer
  American Heart Association (米国心臓病学術会議)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08081
[Presentation] Repeated social defeat exaggerates fibrin-rich clot formation in FeCl3-induced arterial thrombosis model: Potential mechanisms of depression-related CVD development.2019
- Author(s)
  Sugimoto T, Yamada H, Yamamoto K, Kubota H, Miyawaki D, Motoyama S, Wada N, Saburi M, Wakana N, Matoba S.
- Organizer
  第83回日本循環器学会
- Data Source
  KAKENHI-PROJECT-18K08081
[Presentation] Psychological stress increases the vulnerability to high-fat diet-induced insulin resistance by enhancing neutrophil elastase activity in adipose tissue.2018
- Author(s)
  Shinichiro Motoyama, Hiroyuki Yamada, Naotoshi Wada, Makoto Saburi, Takeshi Sugimoto, Hiroshi Kubota, Daisuke Miyawaki, Noriyuki Wakana, Satoaki Matoba.
- Organizer
  American Heart Association (米国心臓病学術会議)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08081
[Presentation] Maternal high-fat diet exaggerates the development of diet-induced insulin resistance in adult offspring by enhancing NLRP3 inflammasome activation.2018
- Author(s)
  Naotoshi Wada, Hiroyuki Yamada, Shinichiro Motoyama, Makoto Saburi, Takeshi Sugimoto, Daisuke Miyawaki, Hiroshi Kubota, Noriyuki Wakana, Satoaki Matoba.
- Organizer
  American Heart Association (米国心臓病学術会議)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08081
[Presentation] Maternal high-fat diet promotes the expansion of abdominal aortic aneurysm in adult offspring by skewing of macrophage differentiation toward osteoclast-like macrophages.2018
- Author(s)
  Makoto Saburi, Hiroyuki Yamada, Naotoshi Wada, Shinichiro Motoyama, Takeshi Sugimoto, Hiroshi Kubota, Daisuke Miyawaki, Noriyuki Wakana, Satoaki Matoba.
- Organizer
  American Heart Association (米国心臓病学術会議)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08081
[Presentation] Augmented neutrophil extracellular traps formation promotes atherosclerosis development in socially defeated apoE-/- mice.2017
- Author(s)
  Yamamoto K, Yamada H, Terada K, Motoyama S, Wada N, Saburi M, Sugimoto T, Kikai M, Wakana N, Matoba S.
- Organizer
  American Heart Association (米国心臓病学術会議)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09162
[Presentation] Maternal high-fat diet promotes palmitate-induced inflammasome activation of bone marrow derived macrophages from adult offspring: Possible mechanisms of increased susceptibility to insulin resistance.2017
- Author(s)
  Wada N, Yamada H, Motoyama S, Yamamoto K, Terada K, Saburi M, Sugimoto T, Kikai M, Wakana N, Matoba S.
- Organizer
  American Heart Association (米国心臓病学術会議)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09162
[Presentation] Repeated psychosocial stress enhances neutrophil elastase activity in adipose tissue: Possible mechanisms of highly vulnerable to diet-induced insulin resistance.2017
- Author(s)
  Motoyama S, Yamada H, Yamamoto K, Terada K, Wada N, Saburi M, Sugimoto T, Kikai M, Wakana N, Matoba S.
- Organizer
  American Heart Association (米国心臓病学術会議)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09162
[Presentation] Repeated social defeat enhances neutrophil extracellular traps formation in vivo and in vitro: Potential implication in the exaggerated atherosclerosis in chronic social stress-exposed apoE-/- mice.2017
- Author(s)
  36.Yamamoto K, Yamada H, Terada K, Motoyama S, Wada N, Saburi M, Kikai M, Wakana N, Matoba S.
- Organizer
  American Heart Association (米国心臓病学術会議)
- Place of Presentation
  New Orleans
- Year and Date
  2017-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09162
[Presentation] Transplantation of brown adipose tissue inhibits atherosclerosis in apoE deficient mice via activation of FGF-21/adiponectin axis.2015
- Author(s)
  Kikai M, Terada K, Yamamoto K, Motoyama S, Wada N, Wakana N, Yamada H.
- Organizer
  米国心臓病学術会議
- Place of Presentation
  オーランド(USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09162
[Presentation] Transplantation of high-cholesterol diet-induced inflammatory periaortic adipose tissue exaggerates atherosclerosis development in recipient apoE deficient mice.2013
- Author(s)
  30. Irie D, Wakana N, Kikai M, Kato T, Kishida S, Kawahito H, Yamada H.
- Organizer
  American Heart Association
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-24591120
[Presentation] Maternal high-fat diet exaggerates atherosclerosis development in adult offspring by augmenting macrophage proinflammatory response in periaortic adipose tissue.2013
- Author(s)
  31. Wakana N, Irie D, Kikai M, Kato T, Kawahito H, Kishida S, Fukai K, Yamada H.
- Organizer
  American Heart Association
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-24591120
[Presentation] Phenotypic conversion of perivascular adipose tissue in uninephrectomized apoE deficient mice : Possible role in the early stage of atherosclerosis in chronic kidney disease2012
- Author(s)
  川人浩之, 山田浩之, 岸田聡, 加藤拓, 入江大介, 福居顕介, 池田宏二, 沖垣光彦, 森泰清, 松原弘明
- Organizer
  第76回日本循環器学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] Periaortic adipose tissue-specific activation of renin angiotensin system along with the adipocytes differentiation contributes to atherosclerosis in apoE-/- mice.2012
- Author(s)
  28. Irie D, Yamada H, Kato T, Kawahito H, Kishida S, Wakana N, Kensuke Fukui, Kouji Ikeda, Mitsuhiko Okigaki, Hiroaki Matsubara.
- Organizer
  American Heart Association　Scientific Session
- Place of Presentation
  Los Angeles, USA
- Data Source
  KAKENHI-PROJECT-24591120
[Presentation] Increased perivascular adipose tissue-specific development in uninephrectomized apoE deficient mice : Possible role in accelerated atherogenesis in chronic kidney disease2011
- Author(s)
  Kawahito H, Yamada H, Kato T, Kishida S, Irie D, Ikeda K, Okigaki M, Matsubara H
- Organizer
  第75回日本循環器学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] Phenotypic conversion of brown to white perivascular adipose tissue in uninephrectomized apoE deficient mice : Possible role in the early stage of atherosclerosis in chronic kidney disease2011
- Author(s)
  Kawahito H, Yamada H, Kishida S, Kato T, Irie D, Fukui K, Ikeda K, Okigaki M, Mori M, Matsubara H
- Organizer
  American Heart Association(米国心臓病学術会議)
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] Phenotypic conversion of perivascular adipose tissue in uninephrectomized apoE deficient mice : Mechanism in the early stage of atherosclerosis in CKD2011
- Author(s)
  川人浩之, 山田浩之, 岸田聡, 加藤拓, 入江大介, 福居顕介, 沖垣光彦, 森泰清, 松原弘明
- Organizer
  第19回日本血管生物医学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] Increased perivascular adipose tissue-specific development in uninephrectomized apoE deficient mice : Possible role in accelerated atherogenesis in chronic kidney disease2011
- Author(s)
  Kawahito H, Yamada H, Kishida S, Kato T, Irie D, Ikeda K, Okigaki M, Mori Y, Matsubara H
- Organizer
  第43回日本動脈硬化学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] 片腎摘出apoE欠損マウスにおける血管周囲脂肪組織の形質変化-慢性腎臓病における動脈硬化進展機序への関与-2011
- Author(s)
  川人浩之, 山田浩之, 入江大介, 福居顕介, 加藤拓, 池田宏二, 沖垣光彦, 森泰清, 松原弘明
- Organizer
  第34回日本高血圧学会総会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] Bone marrow angiotensin AT2 receptor deficiency aggravates atherosclerosis by eliminating macrophage liver X receptor-mediated anti-atherogenic actions2011
- Author(s)
  Kato T, Yamada H, Kawahito H, Irie D, Fukui K, Ikeda K, Okigaki M, Mogi M, Iwai M, Horiuchi M, Matsubara H
- Organizer
  American Heart Association(米国心臓病学術会議)
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] Bone Marrow Angiotensin AT1 Receptor Regulates Differentiation of Monocyte Lineage Progenitors from Hematopoietic Stem Cells2011
- Author(s)
  Yamada H
- Organizer
  第75回日本循環器学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] Impaired periaortic differentiation in angiotensin AT_1 receptor deficient mice : Possible role in pro-inflammatory phenotypic modulation of perivascular adipose tissue2011
- Author(s)
  Irie D, Yamada H, Kato T, Kawahito H, Kishida S, Fukui K, Ikeda K, Okigaki M, Matsubara H
- Organizer
  American Heart Association(米国心臓病学術会議)
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] Bone marrow angiotensin AT_1 receptor regulates differentiation of Monocyte lineage progenitors from hematopoietic stem cells2010
- Author(s)
  Yamada H
- Organizer
  International Congress of Endocrinology
- Place of Presentation
  京都
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] Bone marrow angiotensin AT_1 receptor regulates differentiation of monocyte lineage progenitors from hematopoietic stem cells2010
- Author(s)
  Yamada H, Tsubakimoto Y, Yokoi H, Kishida S, Kato T, Kawahito H, Okigaki M, Matsubara H
- Organizer
  International Symposium on Cardiovascular Endocrinology and Metabolism(CVEM)
- Place of Presentation
  Nara, Japan
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] Cardiovascular protective effects of valsartan are more emphasized in hypertensive patients without prior cardiovascular disease : Sub-analysis of KYOTO HEART Study2010
- Author(s)
  Yamada H
- Organizer
  ESC Congress(欧州心臓病学術会議)
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] AT1受容体による単球系前駆細胞の分化調節と動脈硬化2010
- Author(s)
  山田浩之
- Organizer
  日本高血圧学会総会
- Place of Presentation
  福岡
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] 血管周囲脂肪表現型とレニン・アンジオテンシン系慢性腎臓病はRA系賦活化を介して動脈硬化を進展させる2010
- Author(s)
  川人浩之, 山田浩之, 入江大介, 岸田聡, 加藤拓, 沖垣光彦, 森泰清, 松原弘明
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] Bone marrow angiotensin AT_1 receptor regulates differentiation of Monocyte lineage progenitors from hematopoietic stem cells2010
- Author(s)
  Yamada H, Tsubakimoto Y, Yokoi H, Kishida S, Kato T, Kawahito H, Hirai H, Ashihara E, Maekawa T, Ikeda K, Takahashi T, Okigaki M, Matsubara H
- Organizer
  International Congress of Endocrinology(ICE)
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] Bone marrow AT_1 augments neointima formation by promoting mobilization of smooth muscle progenitors via platelet-derived SDF-1α2010
- Author(s)
  Yamada H, Tsubakimoto Y, Yokoi H, Kishida S, Kato T, Kawahito H, Hirai H, Ashihara E, Maekawa T, Iwai M, Horiuchi M, Ikeda K, Takahashi T, Okigaki M, Matsubara H
- Organizer
  International Congress of Endocrinology(ICE)
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] 慢性腎臓病(CKD)における動脈硬化促進の分子メカニズムーアポE欠損マウスCKD腎臓でのマイクロアレイ解析-2009
- Author(s)
  川人浩之, 山田浩之, 岸田聡, 加藤拓, 高橋知三郎, 沖垣光彦, 森泰清, 松原弘明
- Organizer
  第32回日本高血圧学会総会
- Place of Presentation
  滋賀
- Data Source
  KAKENHI-PROJECT-21590957
[Presentation] Bone Marrow AT1 Receptor Augments Neointima Formation by Promoting Mobilization of Smooth Muscle Progenitor Cells in Platelet-Derived SDF-1α-dependent Manner2008
- Author(s)
  Yamada H, Yokoi H, Tsubakimoto Y, Takata H, Kawahito H, Kishida S, Matsui A, Hirai H, Imanishi J, Ashihara E, Maekawa T, Takahashi T, Okigaki M, Matsubara H.
- Organizer
  American Heart Association (米国心臓病学術会議)
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-19590870
[Presentation] Bone marrow ATI receptor augments neointima formation by promoting mobilization of smooth muscle progenitor cells in a plate let-derived SDF-1α-dependent manner2008
- Author(s)
  Yamada H, Matsubara H
- Organizer
  第16回日本血管生物医学会
- Place of Presentation
  金沢
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-19590870
[Presentation] Bone Marrow Angiotensin AT1 Receptor Regulates Differentiation of Monocyte/Macrophage-Lineage Progenitors from Hematopoietic Stem Cells2008
- Author(s)
  Tsubakimoto Y, Yamada H, Yokoi H, Takata H, Kawahito H, Kishida S, Hirai H, Imanishi J, Ashihara E, Maekawa T, Takahashi T, Okigaki M, Matsubara H.
- Organizer
  American Heart Association (米国心臓病学術会議)
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-19590870
[Presentation] Bone marrow AT1 receptor augments neointima formation by promoting mobilization of smooth muscle progenitor cells in a platelet-derived SDF-1α-dependent manner2008
- Author(s)
  Yamada H, Matsubara H
- Organizer
  第16回日本血管生物医学会
- Place of Presentation
  金沢
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-19590870
[Presentation] アンジオテンシンAT1、AT2受容体は骨髄由来血管前駆細胞の動員・遊走を介し血管障害後内膜増生において拮抗的に作用する2007
- Author(s)
  山田浩之
- Organizer
  第15回日本血管生物医学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2007-11-29
- Data Source
  KAKENHI-PROJECT-19590870
[Presentation] Maternal high-fat diet exaggerates atherosclerosis development in adult offspring by augmenting periaortic adipose tissue-specific proinflammatory response.
- Author(s)
  Wakana N, Irie D, Kikai M, Terada K, Yamamoto Y, Kato T, Kawahito H, Yamada H.
- Organizer
  American Heart Association Scientific Session 2014
- Place of Presentation
  Chicago, USA
- Year and Date
  2014-11-16 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-24591120
[Presentation] Maternal High-fat Diet Exaggerates Atherosclerosis Development in Adult Offspring by Augmenting Macrophage Proinflammatory Response in Periaortic Adipose Tissue.
- Author(s)
  61. 若菜紀之、入江大介、鬼界雅一、加藤拓、川人浩之、岸田聡、福居顕介、山田浩之
- Organizer
  第78回日本循環器学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591120
[Presentation] Transplantation of Periaortic Adipose Tissue from High-fat Diet-induced Obese Mice Exaggerates Atherosclerosis Development in Recipient apoE Deficient Mice.
- Author(s)
  60. 鬼界雅一、若菜紀之、入江大介、加藤拓、岸田聡、川人浩之、福居顕介、山田浩之
- Organizer
  第78回日本循環器学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591120
[Presentation] Transplantation of Periaortic Adipose Tissue from Angiotensin Receptor Blocker-treated Mice Markedly Ameliorates Atherosclerosis Development by Reducing Systemic Inflammatory State.
- Author(s)
  59. 入江大介、若菜紀之、鬼界雅一、加藤拓、岸田聡、川人浩之、山田浩之
- Organizer
  第78回日本循環器学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591120

1. MATSUBARA Hiroaki (10239072)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results

YAMADA Hiriyuki 山田 浩之

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Co-Researchers

Precision medicine for cardiovascular diseases by targeting clonal hematopoiesis of indeterminate potential via fetal programmingPrincipal Investigator

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Novel therapeutic strategy for arterial thrombosis by targeting neutrophil extracellular trap formation in socially defeated micePrincipal Investigator

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Novel therapeutic strategy for atherosclerosis by regulating myeloid lineage cells in socially defeated micePrincipal Investigator

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A novel therapeutic strategy for atherosclerotic diseases by regulating developmental gene expression in perivascular adipose tissuePrincipal Investigator

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Identification of a novel gene to promote atherosclerosis development by regulating fatty acid binding protein secreted from dysfunctional kidneyPrincipal Investigator

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Role of T lymphocyte activation by angiotensin II in the development of vulnerable plaquePrincipal Investigator

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Analysis of the mechanisms for antiatherogenic effect of bone marrow AT2 receptor by using gene-targeted micePrincipal Investigator

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発生工学を用いたアンジオテンシンAT2受容体の樹状細胞分化と抗動脈硬化作用の解析Principal Investigator

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[Book] THE ARB2006

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[Journal Article] Repeated Social Defeat Enhances CaCl2-Induced Abdominal Aortic Aneurysm Expansion by Inhibiting the Early Fibrotic Response via the MAPK-MKP-1 Pathway.2022

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[Journal Article] Maternal High-Fat Diet Promotes Abdominal Aortic Aneurysm Expansion in Adult Offspring by Epigenetic Regulation of IRF8-Mediated Osteoclast-like Macrophage Differentiation.2021

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[Journal Article] Adrenergic receptor-mediated activation of FGF-21-adiponectin axis exerts atheroprotective effects in brown adipose tissue-transplanted apoE-/- mice2018

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[Journal Article] Transplantation of periaortic adipose tissue inhibits atherosclerosis in apoE-/- mice by evoking TGF-β1-mediated anti-inflammatory response in transplanted graft.2018

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[Journal Article] Augmented neutrophil extracellular traps formation promotes atherosclerosis development in socially defeated apoE-/- mice2018

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YAMADA Hiriyuki 山田浩之