Harada Masaru 原田大

… Alternative Names

HARADA Masaru 原田大

Less

Researcher Number	00241175
Other IDs
Affiliation (Current)	2023: 産業医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2021: 産業医科大学, 医学部, 教授 2008 – 2016: University of Occupational and Environmental Health, Japan, 医学部, 教授 2003 – 2006: 久留米大学, 医学部, 講師 1993 – 2002: 久留米大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Gastroenterology / Basic Section 52030:Psychiatry-related / Metabolomics
Keywords	Principal Investigator ウイルソン病 / オートファジー / 酸化ストレス / 小胞体ストレス / ATP7B / Mallory-Denk体 / 肝細胞 / 銅 / 脂肪性肝疾患 / 非アルコール性脂肪性肝疾患 … More / プロテアソーム / Wilson disease / C型肝炎 / 細胞内凝集体 / ウイルス性肝炎 / 肝臓学 / ライソゾーム / アシアロ糖蛋白 / 代謝性肝疾患 / ストレス顆粒 / Hippo-YAP経路 / p62 / Inclusion body / Mallory body / Cooper / ユビキチン / 中間径フィラメント / プロテアソームゴルジ装置 / aggresome / マロリー体 / 中間系線維 / Mallory体 / hepatocytes / copper / bile / 胆汁 / ウィルソン病 / ウイルス性肝疾患 / 封入体形成 / 肝疾患 / 蛋白分解 / ケラチン / エンドサイトーシス / 細胞骨格 … More Except Principal Investigator insulin receptor substrate / G1 arrest / Bcl-xL / MRP2 / p27 / Skp2 / Insulin receptor substrate / HOMA-IR / HepG2 cell / 2型糖尿病 / HepG2細胞 / 糖尿病 / ChREBP / in situ hybridization / 肝細胞 / VEGF / 免疫組織化学 / Heat Shock Protein / 脳由来神経栄養因子 / 病態生理 / MRI / HVA / MHPG / コネクトーム / BDNF / IGF-1 / エキソソーム / 脳画像 / 脳内ネットワーク / アルギニン一酸化窒素経路 / キヌレニン経路 / 神経画像 / 神経免疫 / 神経炎症 / うつ病 / PPARgamma / SOD / PPARγ / Intracellular insulin signaling / Interferon / HCV core / Insulin resistance / Hepatitis C virus / インスリンシグナル伝達分子 / SOCS-3 / C型肝炎ウイルスコア抗原 / 一般住民 / C型肝炎ウイルス高感染地区 / ケース・コホート研究 / C型慢性肝炎 / 免疫染色 / トランスジェニックマウス / ウイルス駆除 / 細胞内インスリンシグナル / インターフェロン / HCVコア抗原 / インスリン抵抗性 / C型肝炎ウイルス / diabetes mellitus / insulin receptor / gene mutation / insulin secretion / INS-1 cell / luciferase reporter assay / InsZ / 遺伝子導入 / インスリンプロモータ領域 / siRNA / 細胞内局在変化 / Nuclear localization signal / INS-1細胞 / 2 / insulin receptor substrate 1 / リン酸化 / インスリン受容体 / 遺伝子変異 / インスリン分泌 / INS-1 / sinusoidal endothelial cell / Hepatocyte / Liver regeneration / 劇症肝炎 / 激症肝炎 / 血管内皮増殖因子 / 類洞内皮細胞 / 肝再生 / Cultured biliary epithelial cells / Immunohistochemistry / Blind Loop / Endotoxin / Primary Sclerosing Cholangitis / Primary Biliary Cirrhosis / 培養肝細胞 / IgA / 培養胆管細胞 / 原発性胆汁性肝硬変 / Western Blotting / 培養胆管上皮細胞 / 動物モデル / エンドトキシン / 原発性硬化性胆管炎 / 原発性胆汁性肝硬変症 Less

非ウイルス性肝疾患でのオートファジーならびに封入体形成の意義Principal Investigator
- Principal Investigator
  
  原田大
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  University of Occupational and Environmental Health, Japan
Common Pathophysiology between major depression and diabetes mellitus
- Principal Investigator
  
  YOSHIMURA REIJI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  University of Occupational and Environmental Health, Japan
Endoplasmic reticulum stress, Mallory-Denk body and autophagy in fatty liver diseasePrincipal Investigator
- Principal Investigator
  
  Harada Masaru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  University of Occupational and Environmental Health, Japan
Response of hepatocytes against endoplasmic reticulum stress in chronic liver diseasesPrincipal Investigator
- Principal Investigator
  
  Harada Masaru
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Occupational and Environmental Health, Japan
Role of autophagy in liver diseases associated with stressPrincipal Investigator
- Principal Investigator
  
  HARADA Masaru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Occupational and Environmental Health, Japan
Mechanisms of Mallory body formation and elimination in hepatocytesPrincipal Investigator
- Principal Investigator
  
  HARADA Masaru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Occupational and Environmental Health, Japan
MOLECULAR MECHANISMS FOR THE DEVELOPMENT OF HEPATITIS C VIRUS-RELATED INSULIN RESISTANCE
- Principal Investigator
  
  SATA Michio
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kurume University
Chemotherapeutic Effect of Cell-cycle Modulation in Skp2-targeting Strategy for Liver Cancer
- Principal Investigator
  
  KOGA Hironori
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kurume University
BIOLOGICAL ROLES OF NEW TRANSCRIPTION FACTOR FOR GLUCOSE METABOLISM(ChREBP) IN PANCREATIC ISLET CELLS
- Principal Investigator
  
  KAWAGUCHI Takumi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  KURUME UNIVERSITY SCHOOL OF MEDICINE
Biological significance of the expression of a Wilson disease mutant proteinPrincipal Investigator
- Principal Investigator
  
  HARADA Masaru
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kurume University
Intracellular localization of Wilson disease protein(ATP7B), a copper-transporting ATPase.Principal Investigator
- Principal Investigator
  
  HARADA Masaru
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kurume University school of Medicine
VEGF can be a vulnerable candidate as a therapeutic agents for severe and fulminant hepatitis?
- Principal Investigator
  
  SAKISAKA Shotaro
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Fukuoka University
  Kurume University
アシアロ糖蛋白の肝細胞内での代謝機構Principal Investigator
- Principal Investigator
  
  原田大
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Kurume University
アシアログライコプロテインのエンドサイトーシスならびに細胞内トランスポートPrincipal Investigator
- Principal Investigator
  
  原田大
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Kurume University
Studies on Pathogenesis of Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis
- Principal Investigator
  
  SAKISAKA Shotaro
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kurume University School of Medicine

[Book] 内科学2022
- Author(s)
  原田　大
- Total Pages
  2
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-21K07926
[Book] 別冊日本臨床　肝・胆道系症候群（第3版）‐その他の肝・胆道系疾患を含めて- 肝臓編（下）2021
- Author(s)
  原田　大、大江　晋司、草永　真志
- Total Pages
  4
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-21K07926
[Book] 消化器疾患最新の治療2021-20222021
- Author(s)
  原田　大
- Total Pages
  2
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-21K07926
[Book] 今日の治療薬2021
- Author(s)
  原田　大
- Total Pages
  1
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21K07926
[Book] The evolving landscape of liver cirrhosis management2019
- Author(s)
  Harada M
- Total Pages
  220
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-18K07988
[Book] 消化器疾患　最新の治療2017
- Author(s)
  原田　大
- Total Pages
  504
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-26461026
[Book] ウイルス肝炎・肝癌の病態と治療2016
- Author(s)
  原田　大、日浦　政明、宮川　恒一郎、大江　晋司、本間　雄一
- Total Pages
  173
- Publisher
  嵯峨野
- Data Source
  KAKENHI-PROJECT-26461026
[Book] 消化器　研修ノート2016
- Author(s)
  原田　大
- Total Pages
  664
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-26461026
[Book] The Liver in Systeminc Diseases2016
- Author(s)
  Hino K, Harada M
- Total Pages
  343
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26461026
[Book] The liver in systemic disease2016
- Author(s)
  Hino K, Harada M
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26461026
[Book] 日本肝臓学会　教育講演会テキスト2015
- Author(s)
  原田　大
- Total Pages
  161
- Publisher
  日本肝臓学会
- Data Source
  KAKENHI-PROJECT-26461026
[Book] Hepatology Practice 第４巻　難治性肝疾患の診療を極める2014
- Author(s)
  原田　大,原田　理子
- Total Pages
  4
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-26461026
[Book] 消化器病診療　第2版2014
- Author(s)
  原田　大
- Total Pages
  4
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-26461026
[Book] 代謝性肝疾患2013
- Author(s)
  原田大
- Publisher
  日本肝臓学会.教育講演会テキスト
- Data Source
  KAKENHI-PROJECT-23591000
[Book] NASH・アルコール性肝障害の診療を極める　基本から最前線まで2013
- Author(s)
  原田　大
- Total Pages
  2
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-23591000
[Book] ウイルス肝炎・肝癌の病態と治療 (培養肝癌細胞への分子標的薬の影響)2013
- Author(s)
  原田大
- Publisher
  メディカルトリビューン
- Data Source
  KAKENHI-PROJECT-23591000
[Book] 日本肝臓学会　教育講演会テキスト2013
- Author(s)
  原田　大
- Total Pages
  9
- Publisher
  日本肝臓学会
- Data Source
  KAKENHI-PROJECT-23591000
[Book] NASH・アルコール性肝障害の診療を極める基本から最前線まで (肝細胞Mallory-Denk体の生成機構)2013
- Author(s)
  原田大
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-23591000
[Book] 朝倉内科学2013
- Author(s)
  原田　大
- Total Pages
  3
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-23591000
[Book] 免疫疾患イラストレイテッド2013
- Author(s)
  原田　大
- Total Pages
  6
- Publisher
  自己免疫性肝炎
- Data Source
  KAKENHI-PROJECT-23591000
[Book] 朝倉内科学2013
- Author(s)
  原田大
- Total Pages
  2
- Publisher
  ウイルソン病
- Data Source
  KAKENHI-PROJECT-23591000
[Book] ウイルソン病2013
- Author(s)
  原田大
- Publisher
  朝倉書店朝倉内科学
- Data Source
  KAKENHI-PROJECT-23591000
[Book] ウィルソン病.肝硬変改訂第2版2013
- Author(s)
  原田大、本間雄一、千手倫夫
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-23591000
[Book] ウイルス肝炎・肝癌の病態と治療2013
- Author(s)
  原田　大
- Total Pages
  6
- Publisher
  メディカルトリビューン
- Data Source
  KAKENHI-PROJECT-23591000
[Book] 分子生物学が可能とした個別化医療 (トレハロースはオートファジーを介して肝細胞の小胞体ストレスを軽減するか?)2012
- Author(s)
  本間雄一、原田大
- Publisher
  アークメディア
- Data Source
  KAKENHI-PROJECT-23591000
[Book] 病気の分子形態学2011
- Author(s)
  原田　大　他．
- Total Pages
  370
- Publisher
  学際企画
- Data Source
  KAKENHI-PROJECT-23591000
[Book] モノグラフ病気の分子形態学 (ウイルソン病)2011
- Author(s)
  原田大, 本間雄一, 原田理子
- Publisher
  学際企画
- Data Source
  KAKENHI-PROJECT-23591000
[Book] 肝・胆道系症候群2010
- Author(s)
  原田大
- Total Pages
  3
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-20590798
[Book] アークメディア分子標的薬2010
- Author(s)
  原田大、本間雄一、佐藤みゆき、香月友香
- Data Source
  KAKENHI-PROJECT-20590798
[Book] 遺伝性肝疾患2010
- Author(s)
  原田大
- Total Pages
  4
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-20590798
[Book] 分子標的薬2010
- Author(s)
  原田大
- Total Pages
  2
- Publisher
  アークメディア
- Data Source
  KAKENHI-PROJECT-20590798
[Book] 肝疾患Review 2010-20112010
- Author(s)
  原田大
- Total Pages
  4
- Publisher
  日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-20590798
[Book] 日本メディカルセンター肝疾患Review 2010-20112010
- Author(s)
  原田大、本間雄一、日浦政明
- Data Source
  KAKENHI-PROJECT-20590798
[Book] 消化器疾患にかけるエピゲノイクスとゲノミクス2009
- Author(s)
  原田大
- Total Pages
  5
- Publisher
  アークメディア
- Data Source
  KAKENHI-PROJECT-20590798
[Book] アークメディア消化器疾患におけるエピゲノミクスとゲノミクス2009
- Author(s)
  原田大
- Data Source
  KAKENHI-PROJECT-20590798
[Book] 肝疾患Review2004
- Author(s)
  原田大
- Total Pages
  237
- Publisher
  日本メデイカルセンター
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Book] 肝疾患 Review2004
- Author(s)
  原田大
- Total Pages
  237
- Publisher
  日本メデイカルセンター
- Data Source
  KAKENHI-PROJECT-14570528
[Book] 肝疾患と生体元素2003
- Author(s)
  原田大他
- Total Pages
  214
- Publisher
  日本学会事務センター
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Book] 病気の形態学2002
- Author(s)
  原田大他
- Total Pages
  265
- Publisher
  学際企画
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] アルコールと肝疾患2022
- Author(s)
  原田　大
- Journal Title
  
  日本消化器病学会雑誌
  
  Volume: 119
- NAID
  130008140836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07926
[Journal Article] Trends in hepatocellular carcinoma incident cases in Japan between 1996 and 20192022
- Author(s)
  Nakano M, Yatsuhashi H, Bekki S, Takami Y, Tanaka Y, Yoshimaru Y, Honda K, Komorizono Y, Harada M, Shibata M, Sakisaka S, Shakado S, Nagata K, Yoshizumi T, Itoh S, Sohda T, Oeda S, Nakao K, Sasaki R, Yamashita T, Ido A, Mawatari S, Nakamuta M, Aratake Y, Matsumoto S, Maeshiro T, Goto T, Torimura T
- Journal Title
  
  Sci Rep
  
  Volume: 12 Issue: 1 Pages: 1517-1517
- DOI
  10.1038/s41598-022-05444-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07926
[Journal Article] ヘモクロマトーシス2022
- Author(s)
  原田　大、本間雄一、熊元啓一郎
- Journal Title
  
  肝胆膵
  
  Volume: 84 Pages: 443-446
- Data Source
  KAKENHI-PROJECT-21K07926
[Journal Article] Airborne fine particulate matter in Japan induces lipid synthesis and inhibits autophagy in HepG2 cells.2021
- Author(s)
  Ogino N, Miyagawa K, Nagaoka K, Sumida K, Kusanaga M, Oe S, Honma Y, Shibata M, Harada M, Suganuma N, Ogino K
- Journal Title
  
  Int J Biochem Cell Biol
  
  Volume: 141 Pages: 106099-106099
- DOI
  10.1016/j.biocel.2021.106099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07926, KAKENHI-PROJECT-20K17037
[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)12021
- Author(s)
  Daniel J Klionsky、Shu Aizawa、Amal Kamal Abdel-Aziz、Sara Abdelfatah、Mahmoud Abdellatif、Asghar Abdoli、Steffen Abel、Hagai Abeliovich、Marie H Abildgaard、Yakubu Princely Abudu、Abraham Acevedo-Arozena、Iannis E Adamopoulos、Khosrow Adeli、Timon E Adolph、Annagrazia Adornetto、Elma Aflaki、Galila Agam et al.
- Journal Title
  
  Autophagy
  
  Volume: 17 Issue: 1 Pages: 1-382
- DOI
  10.1080/15548627.2020.1797280
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06375, KAKENHI-PROJECT-19K07568, KAKENHI-PROJECT-20K06501, KAKENHI-PROJECT-20K06636, KAKENHI-PROJECT-20K07896, KAKENHI-PROJECT-20K21769, KAKENHI-PLANNED-20H05772, KAKENHI-PROJECT-19H01042, KAKENHI-PROJECT-18H02439, KAKENHI-PROJECT-18H02656, KAKENHI-PROJECT-18H02807, KAKENHI-PROJECT-20J00363, KAKENHI-PROJECT-18K06210, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-18K09427, KAKENHI-PROJECT-19K08851, KAKENHI-PROJECT-18KK0193, KAKENHI-PLANNED-19H05710, KAKENHI-PROJECT-18H02901, KAKENHI-PROJECT-20H02990, KAKENHI-PUBLICLY-20H05504, KAKENHI-PROJECT-19H03471, KAKENHI-PROJECT-19H03791, KAKENHI-PROJECT-20H03249, KAKENHI-PROJECT-21H02812, KAKENHI-PROJECT-19K09677, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-20K08460, KAKENHI-PROJECT-20K08662, KAKENHI-PROJECT-21K07926, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-19K24690
[Journal Article] Correlation of hepatitis C virus-mediated endoplasmic reticulum stress with autophagic flux impairment and hepatocarcinogenesis2021
- Author(s)
  Honma Yuichi、Miyagawa Koichiro、Hara Yuichi、Hayashi Tsuguru、Kusanaga Masashi、Ogino Noriyoshi、Minami Sota、Oe Shinji、Ikeda Masanori、Hino Keisuke、Harada Masaru
- Journal Title
  
  Medical Molecular Morphology
  
  Volume: - Issue: 2 Pages: 108-121
- DOI
  10.1007/s00795-020-00271-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17037, KAKENHI-PROJECT-18K07988, KAKENHI-PROJECT-19H03644, KAKENHI-PROJECT-21K07044, KAKENHI-PROJECT-21K07926, KAKENHI-PROJECT-21K07995
[Journal Article] Possible contribution of hepatocyte secretion to the elevation of plasma exosomal arginase-1 in high-fat diet-fed mice2021
- Author(s)
  Noriyoshi Ogino, Hidekazu Takahashi, Kenjiro Nagaoka, Yuki Harada, Masayuki Kubo, Koichiro Miyagawa, Masashi Kusanaga, Shinji Oe, Yuichi Honma, Masaru Harada, Masamitsu Eitoku, Narufumi Suganuma, Keiki Ogino
- Journal Title
  
  Life Sciences
  
  Volume: 278 Pages: 119588-119588
- DOI
  10.1016/j.lfs.2021.119588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17067, KAKENHI-PROJECT-21K07926, KAKENHI-PROJECT-20K17037
[Journal Article] Role of HO-1 against Saturated Fatty Acid-Induced Oxidative Stress in Hepatocytes2021
- Author(s)
  Ogino N, Miyagawa K, Nagaoka K, Matsuura-Harada Y, Ogino S, Kusanaga M, Oe S, Honma Y, Harada M, Eitoku M, Suganuma N, Ogino K
- Journal Title
  
  Nutrients
  
  Volume: 13 Issue: 3 Pages: 993-993
- DOI
  10.3390/nu13030993
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15766, KAKENHI-PROJECT-18K07988, KAKENHI-PROJECT-17K15977, KAKENHI-PROJECT-21K07926, KAKENHI-PROJECT-20K17037
[Journal Article] Trehalose alleviates oxidative stress-mediated liver injury and Mallor-Denk body formation via activating autophagy in mice2021
- Author(s)
  Honma Y, Sato-Morita M, Katsuki Y, Mihara H, Baba R, Hino K, Kawashima A, Ariyasu T, Harada M.
- Journal Title
  
  Med Mol Morphol.
  
  Volume: 54(1) Issue: 1 Pages: 41-51
- DOI
  10.1007/s00795-020-00258-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K00903, KAKENHI-PROJECT-18K07988, KAKENHI-PROJECT-19K11733, KAKENHI-PROJECT-21K07926, KAKENHI-PROJECT-21K07927, KAKENHI-PROJECT-21K08017
[Journal Article] ウィルソン病　小児期からの発症病と長期的肝胆道合併症2021
- Author(s)
  原田大、大江晋司、草永真志、本間雄一
- Journal Title
  
  肝胆膵
  
  Volume: 82 Pages: 413-416
- Data Source
  KAKENHI-PROJECT-21K07926
[Journal Article] Diagnosis for Wilson disease: this disease may not be a rare disease2021
- Author(s)
  Harada M
- Journal Title
  
  J Gastroenterol
  
  Volume: 56 Issue: 1 Pages: 114-115
- DOI
  10.1007/s00535-020-01752-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07926
[Journal Article] ウイルソン病2021
- Author(s)
  原田　大、草永真志、大江晋司、本間雄一
- Journal Title
  
  消化器・肝臓内科
  
  Volume: 9 Pages: 531-534
- NAID
  10012522014
- Data Source
  KAKENHI-PROJECT-21K07926
[Journal Article] Type 4B hereditary hemochromatosis due to heterozygous p.D157A mutation in SLC40A1 complicated with hypopituitarism.2021
- Author(s)
  Honma Y, Karasuyama T, Kumamoto K, Shimajiri S, Toki Y, Tatsumi Y, Sumida K, Koikawa K, Morino K, Oe S, Miyagawa K, Yamasaki M, Shibata M, Abe S, Ikuta K, Hayashi H, Harada M.
- Journal Title
  
  Medical Molecular Morphology
  
  Volume: 54(1) Issue: 1 Pages: 60-67
- DOI
  10.1007/s00795-020-00259-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08347, KAKENHI-PROJECT-21K07926
[Journal Article] 肝障害で見逃してはならない疾患 Wilson病、α1-アンチトリプシン欠損、原発性胆汁性胆管炎、自己免疫性肝炎2021
- Author(s)
  原田　大
- Journal Title
  
  Medicina
  
  Volume: 58 Pages: 432-434
- Data Source
  KAKENHI-PROJECT-21K07926
[Journal Article] Idiopathic copper toxicosis: is abnormal copper metabolism a primary cause of this disease?2020
- Author(s)
  Harada M, Honma Y, Yoshizumi T, Kumamoto K, Oe S, Harada N, Tanimoto A, Yabuki K, Karasuyama T, Yoneda A, Shibata M.
- Journal Title
  
  Med Mol Morphol.
  
  Volume: 53 Issue: 1 Pages: 50-55
- DOI
  10.1007/s00795-019-00227-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07988
[Journal Article] Direct-acting antiviral agents do not increase the incidence of hepatocellular carcinoma development: a prospective, multicenter study2019
- Author(s)
  Ide T, Koga H, Nakano M, Hashimoto S, Yatsuhashi H, Higuchi N, Nakamuta M, Oeda S, Eguchi Y, Shakado S, Sakisaka S, Yoshimaru Y, Sasaki Y, Honma Y, Harada M, Seike M, Maeshiro T, Miuma S, Nakao K, Mawatari S, Ido A, Nagata K, Matsumoto S, Takami Y, Sohda T, Kakuma T, Torimura T
- Journal Title
  
  Hepatol Int.
  
  Volume: 印刷中 Issue: 3 Pages: 293-301
- DOI
  10.1007/s12072-019-09939-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07988, KAKENHI-PROJECT-18K07945, KAKENHI-PROJECT-19K07788, KAKENHI-PROJECT-18H02798
[Journal Article] Effect of direct-acting antivirals on platelet-associated immune G and thrombocytopenia in hepatitis C virus-related chronic liver disease.2019
- Author(s)
  Honma Y, Shibata M, Hayashi T, Kusanaga M, Ogino N, Minami S, Kumei S, Oe S, Miyagawa K, Senju M, Matsuoka H, Watanabe T, Hiura M, Abe S, Harada M.
- Journal Title
  
  Hepatol Int
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07988
[Journal Article] Predictors of hepatocellular carcinoma recurrence associated with the use of direct-acting antiviral agent therapy for hepatitis C virus after curative treatment: A prospective multicenter cohort study.2019
- Author(s)
  Nakano M, Koga H, Ide T, Kuromatsu R, Hashimoto S, Yatsuhashi H, Seike M, Higuchi N, Nakamuta M, Shakado S, Sakisaka S, Miuma S, Nakao K, Yoshimaru Y, Sasaki Y, Oeda S, Eguchi Y, Honma Y, Harada M, Nagata K, Mawatari S, Ido A, Maeshiro T, Matsumoto S, Takami Y, Sohda T, Torimura T
- Journal Title
  
  Cancer Med.
  
  Volume: 印刷中 Issue: 5 Pages: 2646-2653
- DOI
  10.1002/cam4.2061
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07988, KAKENHI-PROJECT-18K07945, KAKENHI-PROJECT-19K07788, KAKENHI-PROJECT-18H02798
[Journal Article] Involvement of sarco/endoplasmic reticulum calcium ATPase-mediated calcium flux in the protective effect of oleic acid against lipotoxicity in hepatocytes.2019
- Author(s)
  Ogino N, Miyagawa K, Kusanaga M, Hayashi T, Minami S, Oe S, Honma Y, Harada M.
- Journal Title
  
  Exp Cell Res
  
  Volume: 385 Issue: 1 Pages: 111651-111651
- DOI
  10.1016/j.yexcr.2019.111651
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07988, KAKENHI-PROJECT-17K15977
[Journal Article] Zinc attenuates the cytotoxicity of some stimuli by reducing endoplasmic reticulum stress in hepatocytes2019
- Author(s)
  Kusanaga M, Oe S, Ogino N, Minami S, Miyagawa K, Honma Y, Harada M
- Journal Title
  
  Int J Mol Sci
  
  Volume: 20 Issue: 9 Pages: 2192-2192
- DOI
  10.3390/ijms20092192
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07988, KAKENHI-PROJECT-17K15977
[Journal Article] ウィルソン病の処方2018
- Author(s)
  原田　大
- Journal Title
  
  Modern Physician
  
  Volume: 38 Pages: 1181-1181
- Data Source
  KAKENHI-PROJECT-18K07988
[Journal Article] A young adult patient with nonalcoholic steatohepatitis developed severe gastroesophageal varices associated with severe obesity and diabetes mellitus2018
- Author(s)
  Honma Y, Sumida K, Ogino N, Kusanaga M, Minami S, Kumei S, Matsuoka H, Watanabe T, Hiura M, Abe S, Shibata M, Harada M
- Journal Title
  
  Case Reports in Gastroenterology
  
  Volume: 12 Issue: 2 Pages: 487-496
- DOI
  10.1159/000492423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07988, KAKENHI-PROJECT-17K15977
[Journal Article] Mallory-Denk体と細胞ストレス2018
- Author(s)
  原田　大、本間　雄一、大江　晋司、南　創太、草永　真志
- Journal Title
  
  肝胆膵
  
  Volume: 76 Pages: 607-612
- Data Source
  KAKENHI-PROJECT-18K07988
[Journal Article] Management for acute liver failure of Wilson disease: indication for liver Transplantation.2017
- Author(s)
  Harada M
- Journal Title
  
  Hepatol Res
  
  Volume: 47 Issue: 4 Pages: 281-282
- DOI
  10.1111/hepr.12717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461026
[Journal Article] Trehalose activates autophagy and decreases proteasome inhibitor-induced endoplasmic reticulum stress and oxidative stress-mediated cytotoxicity in hepatocytes.2017
- Author(s)
  Honma Y, Sato-Morita M, Katsuki Y, Mihara H, Baba R, Harada M
- Journal Title
  
  Hepatol Res
  
  Volume: 印刷中 Issue: 1 Pages: 94-105
- DOI
  10.1111/hepr.12892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461026, KAKENHI-PROJECT-17K00903, KAKENHI-PROJECT-16K00934
[Journal Article] Lipid-induced endoplasmic reticulum stress impairs selective autophagy at the step of autophagosome-lysosome fusion in hepatocytes.2016
- Author(s)
  Miyagawa K, Oe S, Homma Y, Izumi H, Baba R, Harada M.
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 186(7) Issue: 7 Pages: 1861-73
- DOI
  10.1016/j.ajpath.2016.03.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460286, KAKENHI-PROJECT-26461026, KAKENHI-PROJECT-16K00934
[Journal Article] 広がるオートファジーの世界2016
- Author(s)
  原田　大
- Journal Title
  
  肝胆膵
  
  Volume: 73 Pages: 145-147
- Data Source
  KAKENHI-PROJECT-26461026
[Journal Article] ウイルソン病（Wilson病）2016
- Author(s)
  原田　大、大江　晋司、本間　雄一
- Journal Title
  
  肝胆膵
  
  Volume: 72 Pages: 149-154
- NAID
  130005118918
- Data Source
  KAKENHI-PROJECT-26461026
[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy2016
- Author(s)
  Klionsky DJ, Harada M et al.
- Journal Title
  
  Autophagy
  
  Volume: 12 Pages: 1-222
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461026
[Journal Article] ウイルソン病2016
- Author(s)
  原田　大、大江晋司、本間雄一
- Journal Title
  
  肝胆膵
  
  Volume: 72 Pages: 149-154
- NAID
  10012522014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461026
[Journal Article] 肝疾患におけるMallory-Denk体形成とオートファジーの意義2016
- Author(s)
  本間　雄一、日浦　政明、原田　大
- Journal Title
  
  肝胆膵
  
  Volume: 73 Pages: 181-187
- Data Source
  KAKENHI-PROJECT-26461026
[Journal Article] 稀ではない遺伝性疾患：ウイルソン病2016
- Author(s)
  原田　大
- Journal Title
  
  肝臓　クリニカルアップデート
  
  Volume: 2 Pages: 61-63
- Data Source
  KAKENHI-PROJECT-26461026
[Journal Article] Management for acute liver failure of Wilson disease: indication for liver Transplantation.2016
- Author(s)
  Harada M
- Journal Title
  
  Hepatol Res
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461026
[Journal Article] Copper induces hepatocyte injury due to the endoplasmic reticulum stress in cultured cells and patients with Wilson disease2016
- Author(s)
  Oe S, Miyagawa K, Honma Y, Harada M
- Journal Title
  
  Exp Cell Res
  
  Volume: 347 Issue: 1 Pages: 192-200
- DOI
  10.1016/j.yexcr.2016.08.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461026
[Journal Article] ウイルソン病（Wilson病）2016
- Author(s)
  原田　大、大江　晋司
- Journal Title
  
  肝胆膵
  
  Volume: 73 Pages: 963-969
- NAID
  130005118918
- Data Source
  KAKENHI-PROJECT-26461026
[Journal Article] Lipid-induced Endoplasmic Reticulum Stress Impairs Selective Autophagy at The Step of Autophagosome-Lysosome Fusion in Hepatocytes.2016
- Author(s)
  Miyagawa K, Oe S Honma Y, Izumi H, Baba Y, Harada M.
- Journal Title
  
  Am J Pathol
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461026
[Journal Article] ウイルソン病と肝細胞癌2015
- Author(s)
  原田　大
- Journal Title
  
  最新肝癌学
  
  Volume: 73 Pages: 113-115
- Data Source
  KAKENHI-PROJECT-26461026
[Journal Article] Alleviation mechanisms against hepatocyte oxidative stress in patients with chronic hepatic disorders.2015
- Author(s)
  Hiura M, Honma Y, Miyagawa K, Oe S, Shimajiri S, Mihara H, Oe M, Sato-Morita M, Katsuki Y, Harada M.
- Journal Title
  
  Hepatol Res
  
  Volume: in press Issue: 11 Pages: 1124-1135
- DOI
  10.1111/hepr.12478
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461026
[Journal Article] ウイルソン病2015
- Author(s)
  原田　大
- Journal Title
  
  肝臓
  
  Volume: 56 Pages: 639-644
- NAID
  10012522014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461026
[Journal Article] Pathogenesis and management of Wilson disease2014
- Author(s)
  Harada M
- Journal Title
  
  Hepatol Res
  
  Volume: 44 Pages: 395-402
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Sorafenib enhances proteasome inhibitor-induced cell death via inactivation of Akt and stress-activated protein kinases2014
- Author(s)
  Honma Y, Shimizu S, Takehara T, Harada M
- Journal Title
  
  J Gastroenterol
  
  Volume: 49 Pages: 517-526
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Sorafenib enhances proteasome inhibitor-induced cell death via inactivation of Akt and stress-activated protein kinases.2014
- Author(s)
  Honma Y, Shimizu S, Takehara T, Harada M.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 49 Issue: 3 Pages: 517-526
- DOI
  10.1007/s00535-013-0796-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790694, KAKENHI-PROJECT-26461026
[Journal Article] 銅代謝とウイルソン病2014
- Author(s)
  原田大
- Journal Title
  
  細胞
  
  Volume: 46 Pages: 15-17
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] 肝細胞Mallory-Denk体の生成機構2013
- Author(s)
  原田　大
- Journal Title
  
  Hepatology practice
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] ウイルソン病の予後2013
- Author(s)
  原田大、本間雄一、原田理子、草永真志、久米井伸介、日浦政明、柴田道彦、渡邊龍之
- Journal Title
  
  肝胆膵
  
  Volume: 66 Pages: 479-483
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Sorafenib enhances proteasome inhibitor-mediated cytotoxicity via inhibition of unfolded protein response and keratin phosphorylation2013
- Author(s)
  Honma Y, Harada M
- Journal Title
  
  Exp Cell Res
  
  Volume: 319 Pages: 2166-2178
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy.2012
- Author(s)
  Klionsky DJ, Harada M et al.
- Journal Title
  
  Autophagy
  
  Volume: 8 Pages: 445-544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Poorly differentiated neuroendocrine carcinoma of the pancreas responsive to combination therapy with gemcitabine and S-1.2012
- Author(s)
  Yamamoto M, Miyagawa K, Hiura M, Taguchi M, Kihara Y, Abe S, Shimajiri S, Harada M
- Journal Title
  
  Intern Med
  
  Volume: 51 Pages: 727-732
- NAID
  130002061835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Aging modulates susceptibility to mouse liver Mallory-Denk body formation2012
- Author(s)
  Hanada S, Harada M, Akiba J, Abe M, Sakata M, Taniguchi E, Kawaguchi T, Koga H, Nagata E, Ueno T, Omary MB, Sata M
- Journal Title
  
  J Histochem Cytochem
  
  Volume: 60 Pages: 475-483
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Valsartan, a specific angiotensin II receptor blocker, inhibits pancreatic fluid secretion via vagal afferent pathway in conscious rats.2012
- Author(s)
  Yamamoto M, Wei L, Otani M, Harada M, Otsuki M
- Journal Title
  
  Regul Pept
  
  Volume: 178 Issue: 1-3 Pages: 80-85
- DOI
  10.1016/j.regpep.2012.06.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Churg-Strauss syndrome manifesting as cholestasis and diagnosed by liver biopsy.2012
- Author(s)
  Harada M, Oe S, Shibata M, Taguchi M, Matsuhashi T, Hiura M, Abe S, Harada R, Shimairi S
- Journal Title
  
  Hepatol Res
  
  Volume: 42 Issue: 9 Pages: 940-944
- DOI
  10.1111/j.1872-034x.2012.00993.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Adding diet and exercise counseling to the health promotion plan alleviates anthropometric and metabolic complications in patients with metabolic syndrome.2012
- Author(s)
  Morita-Suzuki S, Fujioka Y, Mitsuoka H, Tashiro M, Harada M
- Journal Title
  
  Nutrition and Metabolic Insights
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Keratin 8 phosphorylation regulates its transamidation and hepatocyte Mallory-Denk body formation2012
- Author(s)
  Kwan R, Hanada S, Harada M, (equal contribution), Strnad P, Li DH, Omary MB
- Journal Title
  
  FASEB J
  
  Volume: 26 Pages: 2318-2326
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Aging modulates susceptibility to mouse liver Mallory-Denk body formation.2012
- Author(s)
  Hanada S, Harada M, Akiba J, Abe M, Sakata M, Taniguchi E, Kawaguchi T, Koga H, Nagata E, Ueno T, Omary MB, Sata M
- Journal Title
  
  J Histochem Cytochem
  
  Volume: 60 Issue: 6 Pages: 475-483
- DOI
  10.1369/0022155412441478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Keratin 8 phosphorylation regulates its transamidation and hepatocyte Mallory-Denk body formation.2012
- Author(s)
  Kwan R, Hanada S, Harada M, (equal contribution), Strnad P, Li DH, Omary MB
- Journal Title
  
  FASEB J
  
  Volume: 26 Issue: 6 Pages: 2318-2326
- DOI
  10.1096/fj.11-198580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Keratin 8 phosphorylation regulates its2012
- Author(s)
  Kwan R, Hanada S, Harada M et al.
- Journal Title
  
  FASEB J
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Aging modulates susceptibility2012
- Author(s)
  Hanada S, Harada M et al.
- Journal Title
  
  J Histochem Cytochem
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] 中間径線維の構成成分であるケラチンの糖化は細胞の保護に重要である2011
- Author(s)
  原田大
- Journal Title
  
  Frontiers in Gastroenterology
  
  Volume: 16 Pages: 158-159
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Rapid progression of hepatocellular carcinoma in a patient with autoimmune hepatitis2011
- Author(s)
  Yamamoto K, Hiura M, Tabaru A, Honma Y, Narita R, Abe S, Shimajiri S, Okamoto K, Yamaguchi K, Harada M
- Journal Title
  
  Intern Med
  
  Volume: 50 Pages: 1409-1413
- NAID
  130000770517
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] 肝細胞Mallory-Denk体の形成と細胞生物学的意義2011
- Author(s)
  原田大, 本間雄一, 日浦政明
- Journal Title
  
  細胞
  
  Volume: 43 Pages: 444-447
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] 肝疾患でのオートファジーの意義2011
- Author(s)
  原田大
- Journal Title
  
  産業医科大学雑誌
  
  Volume: 33 Pages: 337-344
- NAID
  110008798970
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] B型肝炎ウイルスは宿主の細胞のオートファジー2011
- Author(s)
  原田　大
- Journal Title
  
  Frontiers in Gastroenterology
  
  Volume: 16 Pages: 150-151
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Case of severe liver damage after the induction of ttocilizumab therapy for rheumatoid vasculitis2011
- Author(s)
  Hiura M, Abe S, Tabaru A, Shimajiri S, Hanami K, Sato K, Tanaka Y, Harada M
- Journal Title
  
  Hepatol Res
  
  Volume: 41 Pages: 492-496
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] 肝細胞のMallory-Denk体の形成と細胞生物学的意義2011
- Author(s)
  原田　大　他．
- Journal Title
  
  細胞
  
  Volume: 43 Pages: 444-447
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] B型肝炎ウイルスは宿主の細胞のオートファジーを利用して増殖している2011
- Author(s)
  原田大
- Journal Title
  
  Frontiers in Gastroenterology
  
  Volume: 16 Pages: 150-151
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Copper incorporation into ceruloplasmin is regulated by Niemann-Pick C1 protein2011
- Author(s)
  Yanagimoto C, Harada M, Kumemura H, Abe M, Koga H, Sakata M, Kawaguchi T, Terada K, Hanada S, Taniguchi E, Ninomiya H, Ueno T, Sugiyama T, Sata M
- Journal Title
  
  Hepatol Res
  
  Volume: 41 Pages: 484-491
- NAID
  10031144114
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Late diagnosed Wilson disease with hepatic2011
- Author(s)
  Honma Y, Harada M, Sato M, et al.
- Journal Title
  
  Hepatol Res
  
  Volume: 41 Pages: 270-276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] 中間径線維の構成成分であるケラチン2011
- Author(s)
  原田　大
- Journal Title
  
  Frontiers in Gastroenterology
  
  Volume: 16 Pages: 158-159
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] ウイルソン病での銅沈着への細胞レベルでの反応2011
- Author(s)
  原田大
- Journal Title
  
  Frontiers in Gastroenterology
  
  Volume: 16 Pages: 154-155
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] ウイルソン病での銅沈着への細胞2011
- Author(s)
  原田　大
- Journal Title
  
  Frontiers in Gastroenterology
  
  Volume: 16 Pages: 154-155
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] 小胞体ストレスにより2011
- Author(s)
  原田　大
- Journal Title
  
  Frontiers in Gastroenterology
  
  Volume: 16 Pages: 152-153
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] ケラチンの変異は急性肝障害の進展に関与する2011
- Author(s)
  原田大
- Journal Title
  
  Frontiers in Gastroenterology
  
  Volume: 16 Pages: 156-157
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Late diagnosed Wilson disease with hepatic and neurological manifestations.2011
- Author(s)
  Honma Y, Harada M, Sato M, Katsuki Y, Hiura M, Shibata M, Narita R, Harada R, Abe S, Tabaru A, Tajiri N, Simajiri S
- Journal Title
  
  Hepatol Res 41
  
  Pages: 270-276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590798
[Journal Article] 小胞体ストレスによりactivating transcription factor-6(ATF-6)欠損マウスは脂肪肝を起こす2011
- Author(s)
  原田大
- Journal Title
  
  Frontiers in Gastroenterology
  
  Volume: 16 Pages: 152-153
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] A case of adult autoimmune hepatitis with histological features of giant cell hepatitis2011
- Author(s)
  Hayashi H, Narita R, Hiura M, Abe S, Tabaru A, Tanimoto A, Sasaguri Y, Harada M
- Journal Title
  
  Intern Med
  
  Volume: 50 Pages: 315-319
- NAID
  130000413115
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Case of severe liver damage after the induction2011
- Author(s)
  Hiura M, Harada M et al.
- Journal Title
  
  Hepatol Res
  
  Volume: 41 Pages: 492-496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Excess copper chelating therapy for Wilson disease induces anemia and liver dysfunction2011
- Author(s)
  Harada M, Miyagawa K, Honma Y, Hiura M, Shibata M, Matsuhashi T, Abe S, Harada R, Tabaru A
- Journal Title
  
  Intern Med
  
  Volume: 50 Pages: 1461-1464
- NAID
  130000969422
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Late diagnosed Wilson disease with hepatic and neurological manifestations2011
- Author(s)
  Honma Y, Harada M, Sato M, Katsuki Y, Hiura M, Shibata M, Narita R, Harada R, Abe S, Tabaru A, Tajiri N, Simajiri S
- Journal Title
  
  Hepatol Res
  
  Volume: 41 Pages: 270-276
- Data Source
  KAKENHI-PROJECT-23591000
[Journal Article] Autophagy is involved in the elimination of intracellular inclusions, Mallory-Denk bodies, in hepatocytes2010
- Author(s)
  Masaru Harada
- Journal Title
  
  Med Mol Morphol 43
  
  Pages: 13-18
- NAID
  10026443077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590798
[Journal Article] Autophagy is involved in the elimination of intracellular inclusions, Mallory-Denk bodies, in hepatocytes.2010
- Author(s)
  Harada M
- Journal Title
  
  Med Mol Morphol 43
  
  Pages: 13-18
- NAID
  10026443077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590798
[Journal Article] 肝細胞Mallory-Denk体の細胞生物学的意義2010
- Author(s)
  原田大
- Journal Title
  
  Medical Review 55
  
  Pages: 268-269
- Data Source
  KAKENHI-PROJECT-20590798
[Journal Article] Wilson disease and its current problems.2010
- Author(s)
  Masaru Harada
- Journal Title
  
  Intern Med
  
  Volume: 49 Pages: 807-808
- NAID
  130000251876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590798
[Journal Article] Autophagy is involved in the elimination of intracellular inclusions, Mallory-Denk bodies, in hepatocytes2010
- Author(s)
  Masaru Harada
- Journal Title
  
  Med Mol Morphol
  
  Volume: 43 Pages: 13-18
- NAID
  10026443077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590798
[Journal Article] Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the CCl4 and thioacetamide models.2008
- Author(s)
  Strnad P, Tao GZ, Zhou Q, Harada M, Toivola DM, Brunt EM, Omary MB
- Journal Title
  
  Gastroenterology 134
  
  Pages: 1169-1179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590798
[Journal Article] Autophagy modulates keratin-containing inclusion formation and apoptosis in cell culture in a context-dependent fashion.2008
- Author(s)
  Harada M, Strnad P, Toivola DM, Omary MB
- Journal Title
  
  Exp Cell Res 314
  
  Pages: 1753-1764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590798
[Journal Article] Autophagy activation by rapamyc in eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation2008
- Author(s)
  Masaru Harada, et al.
- Journal Title
  
  Hepatology 47
  
  Pages: 2026-2035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590798
[Journal Article] Mutation in keratin 18 induces mitochondrial fragmentation in liver-derived epithelial cells.2008
- Author(s)
  Kumemura H, Harada M, Yanagimoto C, Koga H, Kawaguchi T, Hanada S, Taniguchi E, Ueno T, Sata M
- Journal Title
  
  Biochem Biophys Res Commun 367
  
  Pages: 33-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590798
[Journal Article] Autophagy modulates keratin-containing inclusion formation and apoptosis in cell culture in a context-dependent fashion.2008
- Author(s)
  Masaru Harada, et al.
- Journal Title
  
  Experimental Cell Research 314
  
  Pages: 1753-1764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590798
[Journal Article] Autophagy activfation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation.2008
- Author(s)
  Harada M, Hanada S, Toivola DM, Ghori N, Omary MB
- Journal Title
  
  Hepatology 47
  
  Pages: 2026-2035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590798
[Journal Article] The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein2005
- Author(s)
  Harada M et al.
- Journal Title
  
  Am J Pathol. 166
  
  Pages: 499-510
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein.2005
- Author(s)
  Harada M.
- Journal Title
  
  Am J Pathol. 166
  
  Pages: 499-510
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590648
[Journal Article] The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein.2005
- Author(s)
  Harada M et al.
- Journal Title
  
  Am J Pathol. 166
  
  Pages: 499-510
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein2005
- Author(s)
  Harada M
- Journal Title
  
  Am J Pathol 166-2
  
  Pages: 499-510
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590963
[Journal Article] The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein.2005
- Author(s)
  Harada M et al.
- Journal Title
  
  Am J Pathol. 166
  
  Pages: 499-510
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590648
[Journal Article] The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein.2005
- Author(s)
  Harada M
- Journal Title
  
  Am J Pathol. 166・2
  
  Pages: 499-510
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590963
[Journal Article] The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1protein.2005
- Author(s)
  Harada M et al.
- Journal Title
  
  Am J Pathol 166
  
  Pages: 499-510
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] Wilson disease and hepatocellular carcinoma.2004
- Author(s)
  Harada M et al.
- Journal Title
  
  Intern Med. 43
  
  Pages: 1012-1013
- NAID
  10014043069
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] Aggregati n and loss of cytokeratin filament networks inhibit Golgi organization in liver-derived epithelial cell lines2004
- Author(s)
  Kumemura H, Harada M et al.
- Journal Title
  
  Cell Motil Cytoskel 57
  
  Pages: 37-52
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] Wilson disease and hepatocellular carcinoma.2004
- Author(s)
  Harada M.
- Journal Title
  
  Intern Med 43
  
  Pages: 1012-1013
- NAID
  10014043069
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] Wilson病蛋白2004
- Author(s)
  原田大他
- Journal Title
  
  消化器科 39
  
  Pages: 652-656
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] Aggregation and loss of cytokeratin filament networks inhibit Golgi organization in liver-derived epithelial cell lines.2004
- Author(s)
  Kumemura H, Harada M et al.
- Journal Title
  
  Cell Motil Cytoskel 57
  
  Pages: 37-52
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] Wilson病蛋白2004
- Author(s)
  原田大, 他
- Journal Title
  
  消化器科 39
  
  Pages: 652-656
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] ウィルソン病蛋白ATP7Bならびにその変異蛋白の細胞内局在2003
- Author(s)
  原田大他
- Journal Title
  
  肝の生化学箱根シンポジウム 10
  
  Pages: 108-110
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] Proteasome inhibition induces inclusion bodies associated with intermediate filaments and fragmentation of the Golgi apparatus.2003
- Author(s)
  Harada M et al.
- Journal Title
  
  Exp Cell Res. 288
  
  Pages: 60-69
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] Where is the site that ATP7B transports copper within hepatocytes?2003
- Author(s)
  Harada M et al.
- Journal Title
  
  Gastroenterology 125
  
  Pages: 1911-1912
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] Wilson disease protein ATP7B is localized in the late endosomes in a polarized human hepatocyte cell line2003
- Author(s)
  Harada M et al.
- Journal Title
  
  Int J Mol Med 11
  
  Pages: 293-298
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] Proteasome inhibition induces inclusion bodies associated with intermediate filaments and fragmentation of the Golgi apparatus.2003
- Author(s)
  Harada M et al.
- Journal Title
  
  Exp Cell Res 288
  
  Pages: 60-69
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] Wilson disease protein ATP7B is localized in the late endosomes in a polarized human hepatocyte cell line.2003
- Author(s)
  Harada M et al.
- Journal Title
  
  Int J Mol Med. 11
  
  Pages: 293-298
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] ウィルソン病2003
- Author(s)
  原田大他
- Journal Title
  
  肝臓 44
  
  Pages: 501-505
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] ウィルソン病蛋白の局在と変異の影響2002
- Author(s)
  原田大他
- Journal Title
  
  消化と吸収 25
  
  Pages: 16-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] Wilson disease.2002
- Author(s)
  Harada M et al.
- Journal Title
  
  Med Electron Micro 35
  
  Pages: 61-66
- NAID
  130005118918
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] Wilson disease2002
- Author(s)
  Harada M.
- Journal Title
  
  Med Electron Micro 35
  
  Pages: 61-66
- NAID
  130005118918
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570528
[Journal Article] Copper incorporation into ceruloplasmin is regulated by Niemann-Pick C1 protein.
- Author(s)
  Yanagimoto C, Harada M, Kumemura H, Abe M, Koga H, Sakata M, Kawaguchi T, Terada K, Hanada S, Taniguchi E, Ninomiya H, Ueno T, Sugiyama T, Sata M
- Journal Title
  
  Hepatol Res (in press)
- NAID
  10031144114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590798
[Journal Article] Rapid progression of hepatocellular carcinoma in a patient with autoimmune hepatitis.
- Author(s)
  Yamamoto K, Hiura M, Tabaru A, Honma Y, Narita R, Abe S, Shimajiri S, Okamoto K, Yamaguchi K, Harada M
- Journal Title
  
  Intern Med (in press)
- NAID
  130000770517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590798
[Journal Article] Excess copper chelating therapy for Wilson disease induces anemia and liver dysfunctions.
- Author(s)
  Harada M, Miyagawa K, Honma Y, Hiura M, Shibata M, Matsuhashi T, Abe S, Harada R, Tabaru A
- Journal Title
  
  Intern Med (in press)
- NAID
  130000969422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] Keep1-Nrf2システムに対するMallory-Denk体の役割2022
- Author(s)
  大江　晋司、林　倫留、草永　真志、荻野　学芳、宮川　恒一郎、本間　雄一、原田　大
- Organizer
  第17回酸化ストレスと肝研究会
- Data Source
  KAKENHI-PROJECT-21K07926
[Presentation] 肝細胞の各種ストレスへの対応2022
- Author(s)
  原田　大
- Organizer
  第17回酸化ストレスと肝研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07926
[Presentation] 遺伝性ヘモクロマトーシスとウイルソン病の課題2021
- Author(s)
  本間　雄一、大江　晋司、原田　大
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K07926
[Presentation] PM2.5は肝細胞の脂肪滴形成を誘導し、小胞体ストレスとオートファジーの後期段階の障害を惹起する2021
- Author(s)
  荻野　学芳、宮川　恒一郎、草永　真志、大江　晋司、本間　雄一、柴田　道彦、荻野　景規、菅沼　成文、原田　大
- Organizer
  第53回日本臨床分子形態学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K07926
[Presentation] DAA治療SVR後の新規肝発癌における肥満と糖代謝の意義2021
- Author(s)
  本間　雄一、柴田　道彦、原田　大
- Organizer
  第25回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-21K07926
[Presentation] アルコール性肝障害に関する研究の進歩2021
- Author(s)
  原田　大
- Organizer
  第107回日本消化器病学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07926
[Presentation] 移行期におけるウイルソン病患者の問題点2021
- Author(s)
  大江　晋司、本間　雄一、原田　大
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K07926
[Presentation] Mallory-Denk体による肝細胞保護作用2021
- Author(s)
  林　倫留、大江　晋司、原田　大
- Organizer
  57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K07926
[Presentation] アルコール性肝障害に関する研究の進歩2021
- Author(s)
  原田　大
- Organizer
  第107回日本消化器病学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] 3,5-diethoxy-carbonyl-1,4-dihydrocollidine(DDC)の肝細胞への作用機序2020
- Author(s)
  大江　晋司,　林　倫留,　草永　真志,　宮川　恒一郎,　本間　雄一,　原田　大
- Organizer
  第52回日本臨床分子形態学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] C型肝炎ウイルス陰性化後の肝発癌と治療前オートファジー、細胞ストレスとの関連2020
- Author(s)
  本間　雄一,　柴田　道彦,　林　倫留,　森野　加帆里,　草永　真志,　大江　晋司,　　宮川　恒一郎, 阿部慎太郎,　原田　大
- Organizer
  第38回産業医科大学学会
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] 2型糖尿病での発癌機序に関する検討2020
- Author(s)
  林　倫留,　大江　晋司,　草永　真志,　宮川　恒一郎,　本間　雄一,　原田　大
- Organizer
  第52回日本臨床分子形態学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] Correlation of pretreatment autophagy and cellular with the occurrence of post-SVR HCC in chronic hepatitis C, a propensity score matching analysis.2020
- Author(s)
  Honma Y, Shibata M, Harada M
- Organizer
  第24回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] 糖による肝細胞障害機序の検討2020
- Author(s)
  林　倫留,　大江　晋司,　原田　大
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] C型肝炎ウイルス感染におけるオートファジーの抑制と酸化ストレス2019
- Author(s)
  本間　雄一, 林　倫留, 大江　晋司, 宮川　恒一郎, 原田　大
- Organizer
  酸化ストレスと肝研究会
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] 糖による肝細胞障害機序の検討2019
- Author(s)
  林　倫留,　大江　晋司,　本間　雄一,　原田　大
- Organizer
  日本臨床分子形態学会総会
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] C型肝炎ウイルスによる発癌機序の検討2018
- Author(s)
  原田　大
- Organizer
  第32回犬山シンポジウム
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] 肝細胞の様々なストレスに対する亜鉛の保護作用2018
- Author(s)
  草永　真志，大江　晋司，荻野　学芳，南　創太，宮川　恒一郎，本間　雄一，原田　大
- Organizer
  第22回ウイルソン病研究会学術集会
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] Hepatitis C virus infection inhibits autophagic flux via induction of endoplasmic reticulum stress2018
- Author(s)
  Honma Y, Kusanaga M, Ogino N, Minmai S, Oe S, Miyagawa K, Harada M
- Organizer
  AASLD
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] C型肝炎ウイルス感染によるオートファジーの抑制と細胞ストレス2018
- Author(s)
  本間　雄一，林　倫留，草永　真志，荻野　学芳，南　創太，宮川　恒一郎，大江　晋司，原田　大
- Organizer
  第50回日本臨床分子形態学会総会
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] C型肝疾患でのDAAs治療SVR例の発癌寄与因子の検討-新規線維化マーカーの有用性2018
- Author(s)
  井出　達也，江口　有一郎，原田　大
- Organizer
  第22回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] 銅による細胞障害に対する亜鉛の保護作用2018
- Author(s)
  草永　真志，大江　晋司，荻野　学芳，南　創太，宮川　恒一郎，本間　雄一，原田　大
- Organizer
  第54回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] C型肝炎ウイルス感染による小胞体ストレスの誘導とオートファジーの抑制2018
- Author(s)
  本間　雄一，草永　真志，荻野　学芳，倫留，南　創太，大江晋司，日浦　政明，原田　大
- Organizer
  第54回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] ウイルソン病の分子機構2018
- Author(s)
  原田　大
- Organizer
  第54回日本肝臓学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] 若年で高度の肝線維化進展に至った非アルコール性脂肪肝炎合併2型糖尿病の1例2018
- Author(s)
  秀島　宏典，本間　雄一，日浦　政明，柴田　道彦，原田　大
- Organizer
  第321回日本内科学会九州地方会
- Data Source
  KAKENHI-PROJECT-18K07988
[Presentation] 脂肪性肝疾患における脂肪滴とMallory-Denk bodyの意義2016
- Author(s)
  大江　晋司、宮川　恒一郎、本間　雄一、日浦　政明、原田　大
- Organizer
  第48回　日本臨床分子形態学会総会・学術集会
- Place of Presentation
  くまもと県民交流館パレア（熊本県熊本市）
- Year and Date
  2016-09-23
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] Involvement of endoplasmic reticulum stress in excess copperinduced hepatotoxicity2016
- Author(s)
  Oe S, Miyagawa K, Honma Y, Harada M
- Organizer
  APASL
- Place of Presentation
  グランドプリンスホテル新高輪（東京都港区）
- Year and Date
  2016-02-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] Lipid-induced endoplasmic reticulum stress impairs selective autophagy in hepatocytes2016
- Author(s)
  Miyagawa K, Oe S, Honma Y, Harada M
- Organizer
  APASL
- Place of Presentation
  グランドプリンスホテル新高輪（東京都港区）
- Year and Date
  2016-02-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 肝細胞における選択的オートファジーは飽和脂肪酸による小胞体ストレスで障害される2016
- Author(s)
  宮川　恒一郎、原田　大
- Organizer
  第52回　日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ幕張（千葉県千葉市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 様々な肝細胞障害に対する亜鉛の細胞保護作用2016
- Author(s)
  大江　晋司、宮川　恒一郎、本間　雄一、原田　大
- Organizer
  第52回　日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ幕張（千葉県千葉市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 肝疾患における肝細胞のストレス対応2016
- Author(s)
  原田　大
- Organizer
  第11回　臨床ストレス応答学会大会
- Place of Presentation
  山口大学医学部霜仁会館（山口県宇部市）
- Year and Date
  2016-11-11
- Invited
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] Sorafenib enhances cytotoxicity via inhibition of cellular defense mechanisms2016
- Author(s)
  Honma Y, Oe S, Miyagawa K, Harada M
- Organizer
  APASL
- Place of Presentation
  グランドプリンスホテル新高輪（東京都港区）
- Year and Date
  2016-02-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 非アルコール性脂肪肝炎におけるオートファジーの影響2016
- Author(s)
  本間　雄一、南　創太、荻野　学芳、草永　真志、大江　晋司、宮川　恒一郎、日浦　政明、原田　大
- Organizer
  第34回　産業医科大学学会
- Place of Presentation
  産業医科大学（福岡県北九州市）
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 非アルコール性脂肪性肝疾患におけるオートファジーの動態2016
- Author(s)
  宮川　恒一郎、大江　晋司、本間　雄一、馬場　良子、原田　大
- Organizer
  第48回　日本臨床分子形態学会総会・学術集会
- Place of Presentation
  くまもと県民交流館パレア（熊本県熊本市）
- Year and Date
  2016-09-23
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] Lipid-induced endoplasmic reticulum stress but not hepatic steatosis contributes to blockage of autophagosome-lysosome fusion2015
- Author(s)
  Miyagawa K, Oe S, Honma Y, Harada M
- Organizer
  AASLD LIVER MEETING
- Place of Presentation
  San Francisco
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 肝細胞において過剰な銅が誘導する小胞体ストレス2015
- Author(s)
  大江　晋司、宮川　恒一郎、南　創太、本間　雄一、原田　大
- Organizer
  第47回　日本臨床分子形態学会総会
- Place of Presentation
  長崎大学医学部良順会館、他（長崎県長崎市）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 高脂肪食とDDC（3,5-diethoxycarbonyl-1,4-dihydrocollidine）の同時投与マウスにおけるオートファジーと小胞体ストレス2015
- Author(s)
  大江　晋司、宮川　恒一郎、原田　大
- Organizer
  第101回　日本消化器病学会総会
- Place of Presentation
  仙台国際センター、他（宮城県仙台市）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 肝細胞における銅の毒性とそれに対する亜鉛の影響2015
- Author(s)
  大江　晋司、宮川　恒一郎、南　創太、本間　雄一、日浦　政明、原田　大
- Organizer
  第51回　日本肝臓学会大会総会
- Place of Presentation
  ホテル日航熊本、他（熊本県熊本市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 遺伝性代謝性肝疾患2015
- Author(s)
  原田　大
- Organizer
  平成27年度　日本肝臓学会教育講演会
- Place of Presentation
  砂防会館（東京都千代田区）
- Year and Date
  2015-08-16
- Invited
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 肝細胞におけるオートファジーは脂肪酸組成により変化する2015
- Author(s)
  宮川　恒一郎、大江　晋司、本間　雄一、原田　大
- Organizer
  第19回　日本肝臓学会大会
- Place of Presentation
  グランドプリンスホテル新高輪、他（東京都港区）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 高脂肪食投与マウスへのオートファジー誘導は肝内遊離脂肪酸を増加させる2015
- Author(s)
  大江　晋司、宮川　恒一郎、南　創太、本間　雄一、原田　大
- Organizer
  第19回　日本肝臓学会大会
- Place of Presentation
  グランドプリンスホテル新高輪、他（東京都港区）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 非アルコール性脂肪肝炎モデルにおける細胞内凝集体とオートファジーの影響2015
- Author(s)
  宮川　恒一郎、大江　晋司、原田　大
- Organizer
  第51回　日本肝臓学会大会総会
- Place of Presentation
  ホテル日航熊本、他（熊本県熊本市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] The effect of treatment with chemical chaperones and zinc acetate on hepatocytes treated with excess copper2015
- Author(s)
  Oe S, Miyagawa K, Honma Y, Harada M
- Organizer
  AASLD LIVER MEETING
- Place of Presentation
  San Francisco
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] ウィルソン病の分子機構2015
- Author(s)
  原田　大
- Organizer
  第51回　日本肝臓学会総会　サテライトセミナー
- Place of Presentation
  ホテル日航熊本、他（熊本県熊本市）
- Year and Date
  2015-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 肝におけるオートファジーは脂肪酸流入による小胞体ストレスで障害される2015
- Author(s)
  宮川　恒一郎、大江　晋司、本間　雄一、馬場　良子、原田　大
- Organizer
  第47回　日本臨床分子形態学会総会
- Place of Presentation
  長崎大学医学部良順会館、他（長崎県長崎市）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 肝癌細胞のストレス応答への作用を介したソラフェニブの抗腫瘍効果2015
- Author(s)
  本間　雄一、原田　大
- Organizer
  第47回　日本臨床分子形態学会総会
- Place of Presentation
  長崎大学医学部良順会館、他（長崎県長崎市）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 肝癌細胞における酸化ストレス応答へのソラフェニブの作用2015
- Author(s)
  本間　雄一、南　創太、大江　晋司、宮川　恒一郎、日浦　政明、原田　大
- Organizer
  第51回　日本肝臓学会大会総会
- Place of Presentation
  ホテル日航熊本、他（熊本県熊本市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 慢性ウイルス性肝疾患におけるストレスと細胞の反応2014
- Author(s)
  原田　大, 日浦　政明
- Organizer
  第30回　犬山シンポジウム
- Place of Presentation
  岐阜県犬山　名鉄犬山ホテル
- Year and Date
  2014-08-07
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] C型慢性肝炎患者における酸化ストレスがウイルス増殖およびインターフェロン治療効果に及ぼす影響2013
- Author(s)
  日浦政明、本間雄一、原田大
- Organizer
  第40回日本肝臓学会西部会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] Ｃ型慢性肝炎患者における酸化ストレスが，ウイルス増殖およびインターフェロン治療効果に及ぼす影響2013
- Author(s)
  日浦政明、本間雄一、原田　大
- Organizer
  第40回　日本肝臓学会西部会
- Place of Presentation
  岐阜（岐阜都ホテル）
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 小胞体ストレスによる肝細胞障害へのオートファジーの作用2013
- Author(s)
  本間雄一、大江晋司、宮川恒一郎、日浦政明、原田　大
- Organizer
  第45回　日本臨床分子形態学会総会・学術集会
- Place of Presentation
  福岡（アクロス福岡）
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 代謝性肝疾患2013
- Author(s)
  原田大
- Organizer
  日本肝臓学会教育講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 肝疾患における酸化ストレスとオートファージの関連2013
- Author(s)
  日浦政明、大江晋司、宮川恒一郎、本間雄一、原田　大
- Organizer
  第17回　日本肝臓学会大会
- Place of Presentation
  東京（グランドプリンスホテル新高輪）
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 非アルコール性脂肪肝炎モデルに対するトレハロースの影響2013
- Author(s)
  本間雄一、原田大
- Organizer
  第19回肝病態生理研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 小胞体ストレスによる肝細胞障害へのオートファジーの作用2013
- Author(s)
  本間雄一、大江晋司、宮川恒一郎、日浦政明、原田大
- Organizer
  第44回日本臨床分子形態学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 肝由来培養細胞におけるsorafenibのケラチンのリン酸化への影響2013
- Author(s)
  本間雄一、清水　聡、竹原哲郎、原田　大
- Organizer
  第49回　日本肝臓学会総会
- Place of Presentation
  東京（京王フラザホテル）
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 非アルコール性脂肪肝炎モデルに対するトレハロースの影響2013
- Author(s)
  本間　雄一原田　大
- Organizer
  第21回肝病態生理研究会
- Place of Presentation
  東京（京王フラザホテル）
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 代謝性肝疾患2013
- Author(s)
  原田　大
- Organizer
  日本肝臓学会教育講演会
- Place of Presentation
  東京　砂防会館
- Invited
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 代謝性肝疾患2013
- Author(s)
  原田　大
- Organizer
  平成25年度　日本肝臓学会教育講演会
- Place of Presentation
  東京（砂防会館）
- Invited
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 培養肝癌細胞への分子標的薬の影響2012
- Author(s)
  原田　大
- Organizer
  第29回犬山シンポジウム
- Place of Presentation
  犬山　犬山ホテル
- Invited
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 肝癌細胞におけるsorafenibとプロテアソーム阻害薬の相互作用2012
- Author(s)
  本間雄一、原田大、田原章成
- Organizer
  第16回肝臓学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] Autophagy eliminates components of hepatocyte inclusions Mallory-Denk bodies2012
- Author(s)
  Harada M, Honma Y.
- Organizer
  The 6^<th> international symposium of autophagy 2012
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] トレハロースのオートファジーを介した肝細胞の小胞体ストレスへの作用2012
- Author(s)
  本間雄一、原田大
- Organizer
  第44回日本臨床分子形態学会
- Place of Presentation
  高知
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] ウイルソン病蛋白(ATP7B)とNPC1による肝細胞での銅代謝機構2012
- Author(s)
  原田　大、柳本親利
- Organizer
  肝病態生理研究会
- Place of Presentation
  金沢　ホテル日航金沢
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 培養肝癌細胞への分子標的薬の影響2012
- Author(s)
  原田大
- Organizer
  第29回犬山シンポジウム
- Place of Presentation
  犬山
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] ウイルソン病の実地診療での問題点2012
- Author(s)
  原田　大、本間雄一、柴田道彦
- Organizer
  第16回肝臓学会大会
- Place of Presentation
  神戸　国際会議場
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 肝癌細胞におけるsorafenibとプロテアソーム阻害薬の相互作用2012
- Author(s)
  本間雄一、原田　大、田原章成
- Organizer
  第16回肝臓学会大会
- Place of Presentation
  神戸　国際展示場
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 肝由来培養細胞における分子標的薬と小胞体ストレス応答2012
- Author(s)
  本間雄一、原田大
- Organizer
  第20回浜名湖シンポジウム
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] Autophagy eliminates components of hepatocyte inclusions Mallory-Denk bodies2012
- Author(s)
  Harada M, Honma Y
- Organizer
  The 6th international symposium of autophagy
- Place of Presentation
  沖縄　万国津梁館
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] トレハロースのオートファジーを介した肝細胞の小胞体ストレスへの作用2012
- Author(s)
  本間雄一、原田　大
- Organizer
  第44回日本臨床分子形態学会
- Place of Presentation
  高知　高知市文化プラザ
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 肝由来培養細胞における分子標的薬と小胞体ストレス応答2012
- Author(s)
  本間雄一、原田　大
- Organizer
  第20回浜名湖シンポジウム
- Place of Presentation
  浜松　アクトシティー
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] Wilson病における銅過剰とMallory-Denk体形成の肝細胞への影響2011
- Author(s)
  本間雄一、日浦政明、柴田道彦、阿部慎太郎、田原章成、原田大
- Organizer
  第15回ウイルソン病研究会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 肝細胞でのMallory-Denk body形成を伴う肝障害におけるケラチン18の役割2011
- Author(s)
  原田　大　他．
- Organizer
  日本肝臓学会総会
- Place of Presentation
  ホテルグランパシフィック(東京)
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 小胞体ストレスならびに酸化ストレス関連肝障害におけるオートファジーの役割2011
- Author(s)
  本間雄一、原田大
- Organizer
  第47回肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] Mechanisms of intracellular copper metabolism regulated by ATP7B and Niemann-Pick C1 protein in hepatocytes2011
- Author(s)
  Harada M, Yanagimoto C.
- Organizer
  The 62nd Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 肝細胞でのMallory-Denk体形成を伴う肝障害におけるケラチン18の役割2011
- Author(s)
  原田大、本間雄一、日浦政明
- Organizer
  第47回肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] トレハロースはオートファジーを介して肝細胞の小胞体ストレスを軽減するか2011
- Author(s)
  本間雄一、原田大
- Organizer
  第19回浜名湖シンポジウム
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] トレハロースはオートファジーを介して肝細胞2011
- Author(s)
  本間雄一、原田　大
- Organizer
  浜名湖シンポジウム
- Place of Presentation
  アクトシティー浜松(浜松)
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] ウイルソン病において銅過剰は肝細胞へ如何なる影響を与えているか2011
- Author(s)
  本間雄一、原田大、日浦政明、柴田道彦、阿部慎太郎、田原章成
- Organizer
  第19回肝病態生理研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] Mechanisms of intracellular copper metabolism regulated by ATP7B2011
- Author(s)
  Harada M.
- Organizer
  米国肝臓学会
- Place of Presentation
  モスコーセンター(サンフランシスコ)
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 先天性銅代謝異常症・ウイルソン病の分子機構2011
- Author(s)
  原田　大
- Organizer
  日本顕微鏡学会(招待講演)
- Place of Presentation
  福岡国際会議場(福岡)
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 小胞体ストレスならびに酸化ストレス2011
- Author(s)
  本間雄一、原田　大　他．
- Organizer
  日本肝臓学会総会
- Place of Presentation
  ホテルグランパシフィック(東京)
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] Wilson病における銅過剰2011
- Author(s)
  本間雄一、原田　大　他．
- Organizer
  ウイルソン病研究会
- Place of Presentation
  東邦大学(東京)
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] ウイルソン病蛋白(ATP7B)を介した肝細胞内での銅代謝機構2011
- Author(s)
  原田大、柳本親利
- Organizer
  第15回日本肝臓学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 中間径線維の構成成分であるケラチン18はペプチドとして肝細胞保護に働く2011
- Author(s)
  原田大
- Organizer
  第43回に本臨床分子形態学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] 先天性銅代謝異常症・ウイルソン病の分子機構2011
- Author(s)
  原田大
- Organizer
  日本顕微鏡学会第67回学術講演会
- Place of Presentation
  福岡 (指定講演)
- Data Source
  KAKENHI-PROJECT-23591000
[Presentation] DDC投与マウスモデルにおいて性差がMallory-Denk body形成に与える影響について2010
- Author(s)
  花日慎一郎、原田大, 他
- Organizer
  第14回日本肝臓学会大会
- Place of Presentation
  パシフィコ横浜(横浜市>
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] DDC投与マウスモデルにおいて性差がMallory-Denk Body形成に与える影響について2010
- Author(s)
  花田慎一郎、原田大, Snider N., Brunt E., Hollenberg P.、佐田通夫、Omary, B
- Organizer
  第14回日本肝臓学会大会
- Place of Presentation
  横浜
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] Phosphorylation of keratin 8 is important for Mallory Denk-body formation and protection of hepatocytes.2010
- Author(s)
  Harada M
- Organizer
  Miami Clinical Exchange Program. Liver disease in Japan and USA
- Place of Presentation
  Miami
- Year and Date
  2010-03-16
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] Proteasome inhibition induces Mallory-Denk body in susceptible mice and it is prevented by activation of autophagy2010
- Author(s)
  Masaru Harada
- Organizer
  The 9^<th> JSH Single Topic Conference NASH 2010
- Place of Presentation
  Grand Prince Hotel Takanawa(Tokyo)
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] 肝細胞内封入体Mallory-Denk体の細胞生物学的意義と分解機構2010
- Author(s)
  原田大
- Organizer
  第42回日本臨床分子形態学会総会
- Place of Presentation
  東レ総合研修センター(静岡県)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] Proteasome inhibition induces Mallory-Denk body in susceptible mice and it is prevented by activation of autophagy.2010
- Author(s)
  Harada M
- Organizer
  The 9th JSH single topic conference NASH 2010
- Place of Presentation
  東京
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] DDC投与マウスモデルにおけるMallory-Denk body形成と性差2010
- Author(s)
  花日慎一郎、原田大, 他
- Organizer
  第42回日本臨床分子形態学会総会
- Place of Presentation
  東レ総合研修センター(静岡県)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] 肝細胞内封入体Mallory-Denk体の細胞生物学的意義と分解機構2010
- Author(s)
  原田大
- Organizer
  第42回日本臨床分子形態学会総会・学術集会
- Place of Presentation
  静岡
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] Phosphorylation of keratin 8 is important for Mallory-Denk body formation and protection of hepatocytes2010
- Author(s)
  Masaru Harada
- Organizer
  Liver diseasae in Japan and USA
- Place of Presentation
  University of Miami School of Medicine(Miami, USA)
- Year and Date
  2010-03-16
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] DDC投与マウスモデルにおけるMallory-Denk Body形成と性差2010
- Author(s)
  花田慎一郎、原田大、Snider N., Brunt E、鳥村拓司、上野隆登、佐田通夫、Omary B
- Organizer
  第42回日本臨床分子形態学会総会・学術集会
- Place of Presentation
  静岡
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] DDC投与マウスモデルにおけるMallory-Denk body形成と性差2010
- Author(s)
  花田慎一郎、原田大, 他
- Organizer
  第30回アルコール医学生物学研究会
- Place of Presentation
  久留米翠香園ホテル(久留米市)
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] Mallory-Denk体の細胞生物学的意義2009
- Author(s)
  原田大
- Organizer
  第25回九州肝臓談話会
- Place of Presentation
  熊本
- Year and Date
  2009-09-05
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] Mallory-Denk体の細胞生物学的意義2009
- Author(s)
  原田大
- Organizer
  第25回九州肝臓談話会
- Place of Presentation
  ホテルグリーンピア南阿蘇(熊本県)
- Year and Date
  2009-09-05
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] 封入体関連疾患のオートファジー調節による新しい治療戦略2009
- Author(s)
  原田大、佐田通夫
- Organizer
  第1回福岡県医学会総会
- Place of Presentation
  福岡
- Year and Date
  2009-01-25
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] 肝細胞のMallory-Denk体形成におけるケラチン8リン酸化の意義2009
- Author(s)
  原田大、本間雄一、佐藤みゆき、香月友香
- Organizer
  第17回浜名湖シンポジウム
- Place of Presentation
  浜松
- Year and Date
  2009-12-22
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] 肝細胞でのMallory-Denk body形成におけるケラチン8ならびにそのリン酸化の役割2009
- Author(s)
  原田大
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] 肝細胞でのMallory-Denk body形成におけるケラチン8ならびにそのリン酸化の役割2009
- Author(s)
  原田大
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸ポートピアホテル・神戸国際展示場(神戸市)
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] 肝細胞のMallory-Denk体形成におけるケラチン8リン酸化の意義2009
- Author(s)
  原田大
- Organizer
  第17回浜名湖シンポジウム
- Place of Presentation
  アクトシティ浜松コングレスセンター(浜松市)
- Year and Date
  2009-12-22
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] Autophagy is involved in elimination of components of Mallory-Denk bodies in two different types of mouse models.2008
- Author(s)
  Harada M, Sata M
- Organizer
  The 59^<th> Annual Meeting of the American Association for the Study of Liver Diseases.
- Place of Presentation
  San Francisco
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] Mallory-Denk体形成におけるプロテアソーム、オートファジーの関与2008
- Author(s)
  原田大
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] プロテアソームの機能障害によるMallory-Denk体形成をオートファジーは抑制する。2008
- Author(s)
  原田大
- Organizer
  第16回浜名湖シンポジウム
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] オートファジーはプロテアソームの機能異常によるMallory-Denk体の形成を抑制する。2008
- Author(s)
  原田大
- Organizer
  第40回日本臨床分子形態学会
- Place of Presentation
  福岡
- Year and Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] Mallory-Denk体形成におけるプロテアソーム、オートファジーの役割。2008
- Author(s)
  原田大
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] プロテアソームの機能障害によるMallory-Denk体の形成をオートファジーは抑制する2008
- Author(s)
  原田大、佐田通夫
- Organizer
  第16回浜名湖シンポジウム
- Place of Presentation
  静岡
- Year and Date
  2008-12-21
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] オートファジーはプロテアソームの機能異常によるMallory-Denk体の形成を抑制する2008
- Author(s)
  原田大
- Organizer
  第40回日本臨床分子形態学会
- Place of Presentation
  福岡
- Year and Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-20590798
[Presentation] Carbamazepineはオートファジーを介して飽和脂肪酸による細胞障害，インスリン抵抗性を軽減する
- Author(s)
  宮川　恒一郎, 大江　晋司, 原田　大
- Organizer
  第50回　日本肝臓学会総会
- Place of Presentation
  東京都千代田区　ホテルニューオータニ
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 非アルコール性脂肪性肝疾患（NAFLD）におけるオートファジーの役割
- Author(s)
  宮川　恒一郎, 大江　晋司, 南　創太, 本間　雄一, 日浦　政明, 原田　大
- Organizer
  第18回　日本肝臓学会大会
- Place of Presentation
  兵庫県神戸市　神戸国際会議場
- Year and Date
  2014-10-23 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 小胞体ストレス関連肝疾患に対するスタチンのオートファジーを介した作用
- Author(s)
  本間　雄一, 大江　晋司, 宮川　恒一郎, 日浦　政明, 原田　大
- Organizer
  第50回　日本肝臓学会総会
- Place of Presentation
  東京都千代田区　ホテルニューオータニ
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 肝細胞において銅過剰状態はアポトーシスを誘導し細胞増殖を抑制する
- Author(s)
  大江　晋司, 宮川　恒一郎, 南　創太, 本間　雄一, 日浦　政明, 原田　大
- Organizer
  第18回　日本肝臓学会大会
- Place of Presentation
  兵庫県神戸市　神戸国際会議場
- Year and Date
  2014-10-23 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-26461026
[Presentation] 銅過剰状態における肝細胞障害および化学シャペロンによる抑制効果
- Author(s)
  大江　晋司, 宮川　恒一郎, 本間　雄一, 原田　大
- Organizer
  第50回　日本肝臓学会総会
- Place of Presentation
  東京都千代田区　ホテルニューオータニ
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-26461026

1. KOGA Hironori (90268855)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. SAKISAKA Shotaro (90158923)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KAWAGUCHI Takumi (00320177)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SHAKADO Satoshi (80241181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. OOISHI Masahito (80289412)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TANIMURA Takuji (60197986)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKAMURA Toru (30341332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TANIGUCHI Eitaro (50341318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SATA Michio (10162398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YOSHIDA Takafumi (30368899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAGAO Yumiko (90227992)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YOSHIMURA REIJI (90248568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 権藤和久 (00186909)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 吉武正男 (40182745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 井形亮平 (00739477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 手銭宏文 (00790982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 新開隆弘 (20352304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 掛田伸吾 (30352313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 本間雄一 (30620984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 興梠征典 (60195691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 小西勇輝 (90739476)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 星川大 (20842181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. IKUTA Katsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 馬場良子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
25. 相澤修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 草永真志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 荻野学芳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 宮川恒一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 清水聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 土岐康通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Harada Masaru 原田 大

HARADA Masaru 原田 大

Research Projects

Research Products

Co-Researchers

非ウイルス性肝疾患でのオートファジーならびに封入体形成の意義Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Common Pathophysiology between major depression and diabetes mellitus

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Endoplasmic reticulum stress, Mallory-Denk body and autophagy in fatty liver diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Response of hepatocytes against endoplasmic reticulum stress in chronic liver diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of autophagy in liver diseases associated with stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of Mallory body formation and elimination in hepatocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MOLECULAR MECHANISMS FOR THE DEVELOPMENT OF HEPATITIS C VIRUS-RELATED INSULIN RESISTANCE

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemotherapeutic Effect of Cell-cycle Modulation in Skp2-targeting Strategy for Liver Cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

BIOLOGICAL ROLES OF NEW TRANSCRIPTION FACTOR FOR GLUCOSE METABOLISM(ChREBP) IN PANCREATIC ISLET CELLS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biological significance of the expression of a Wilson disease mutant proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Intracellular localization of Wilson disease protein(ATP7B), a copper-transporting ATPase.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

VEGF can be a vulnerable candidate as a therapeutic agents for severe and fulminant hepatitis?

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アシアロ糖蛋白の肝細胞内での代謝機構Principal Investigator

Principal Investigator

Project Period (FY)

Harada Masaru 原田大

HARADA Masaru 原田大

[Book] 別冊日本臨床　肝・胆道系症候群（第3版）‐その他の肝・胆道系疾患を含めて- 肝臓編（下）2021

[Book] 消化器疾患　最新の治療2017

[Book] 消化器　研修ノート2016

[Book] 日本肝臓学会　教育講演会テキスト2015

[Book] Hepatology Practice 第４巻　難治性肝疾患の診療を極める2014